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Niacin prophylaxis

Utsav Sen, Sudheer Shenoy P, Bipasha Bose
Colorectal cancer is one of the global causes of cancer deaths. Cancer stem cells (CSCs) inside the tumour niche responsible for metastasis and relapses, and hence need to be targeted for cancer therapeutics. Although dietary fibre and lifestyle changes have been recommended as measures for colorectal cancer prevention, no such recommendations are available for using water soluble vitamins as prophylaxis measure for colorectal cancers. High dose of Vitamin C has been proven to selectively kill colon cancer cells having BRAF and KRAS mutations by inducing oxidative stress...
October 2017: Cell Biology International
V N Titov
Hypolipidemic drugs have a common algorithm of action despite differences in its mechanisms. They normalize interaction of cellular receptors with polyenic fatty acids (PFA), restore their functional, regulatory and structural action. Atherosclerosis is in vivo pathology of individual cells unable to incorporate PFA and a syndrome of ω-3 and ω-6 PFA deficiency. Compensatory synthesis of humoral mediators (eicosanoids). from endogenous unsaturated ω-9 C 20:3 dihomo-γ-linolenic (mead) FA imparts on them non-physiological properties and thereby affects in vivo activity of all functional processes and cellular functions, forms the multifaceted clinical picture of pathology and atheromatosis...
2014: Klinicheskaia Meditsina
Terry A Jacobson
Niacin is the most effective lipid-modifying agent for raising high-density lipoprotein cholesterol levels, but it also causes cutaneous vasodilation with flushing. To determine the frequency of flushing in clinical trials, as well as to delineate counseling and treatment approaches to prevent or manage flushing, a MEDLINE search was conducted of English-language literature from January 1, 1985, through April 7, 2009. This search used the title keywords niacin or nicotinic acid crossed with the Medical Subject Headings adverse effects and human...
April 2010: Mayo Clinic Proceedings
Kenneth C Bilchick, Charles A Henrikson, Diane Skojec, Edward K Kasper, Roger S Blumenthal
Of the 60,000 patients receiving heart transplants between 1982 and 2001, approximately 12,000 are currently alive. The high incidence of hyperlipidemia and coronary disease (also known as accelerated graft atherosclerosis, or AGA) in these patients warrants early prophylaxis soon after transplantation with 3-hydroxy-3-methylglutaryl (HMG) Co-A reductase inhibitors (statins). Immunosuppressive agents such as prednisone, cyclosporine, mycophenylate mofetil, and sirolimus are associated with hyperlipidemia. Statins, in addition to lowering cholesterol levels, also benefit cardiac transplant recipients via effects on the immune system and endothelial function...
August 2004: American Heart Journal
R G Oganov, D M Aronov, V B Krasnitskiĭ, N V Perova, A M Olfer'ev, A V Smolenskiĭ, H K Novikov, V A Vygodin
AIM: To evaluate efficacy of combined use of moderate exercise and nicotinic acid drug enduracin in patients with coronary heart disease (CHD) with moderate dyslipidemia (DE). MATERIAL AND METHODS: The effects of exercise therapy alone, enduracin alone and their combination on physical performance (PP), hemodynamics, blood lipid spectrum and clinical course of CHD were studied in 93 CHD patients with moderate DE. The results were evaluated clinically after 1-year treatment...
2004: Terapevticheskiĭ Arkhiv
No abstract text is available yet for this article.
April 27, 1962: Münchener Medizinische Wochenschrift
No abstract text is available yet for this article.
November 1960: Therapie der Gegenwart
David A Velling, David W Dodick, Jesse J Muir
Considerable advances in the diagnosis and treatment of migraine headache have occurred during the past decade, but treatment options for acute migraine attacks have expanded at a faster rate than those for prophylaxis. We describe a patient whose migraine headaches responded dramatically to sustained-release niacin as preventive treatment. Niacin is not generally considered to be effective for migraine prevention. However, low plasma levels of serotonin have been implicated in migraine pathogenesis, and niacin may act as a negative feedback regulator on the kynurenine pathway to shunt tryptophan into the serotonin pathway, thus increasing plasma serotonin levels...
June 2003: Mayo Clinic Proceedings
Anthony V D'Amico, George Toupless, Lynn Lopes, Kristin J Valentine, Robert A Cormack, Clare M Tempany, Sanjaya Kumar, Peter J Marks
No abstract text is available yet for this article.
December 1, 2002: International Journal of Radiation Oncology, Biology, Physics
H B Simon
The control of coronary artery disease requires both physician-directed interventions and patient-directed lifestyle changes that may include nonprescription supplements. All patients should be encouraged to exercise regularly. They should be advised to avoid exposure to tobacco smoke and to strive to attain ideal body weight. Patients should also be encouraged to establish diets that are low in cholesterol and fat and high in dietary fiber. Supplements of water-soluble fiber may be useful for selected patients...
October 24, 1994: Archives of Internal Medicine
A M Tang, N M Graham, A J Kirby, L D McCall, W C Willett, A J Saah
The authors sought to determine if different levels of dietary intake of micronutrients are associated with the progression of human immunodeficiency virus type 1 (HIV-1) infection to acquired immunodeficiency syndrome (AIDS). A total of 281 HIV-1 seropositive homosexual/bisexual men were seen semiannually since 1984 at the Baltimore/Washington, DC site of the Multicenter AIDS Cohort Study. Participants completed a self-administered semiquantitative food frequency questionnaire at baseline. Levels of daily micronutrient intake at baseline were examined in relation to subsequent progression to AIDS (1987 Centers for Disease Control definition; n = 108) during a median follow-up period of 6...
December 1, 1993: American Journal of Epidemiology
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