Johannes Steffen, Stefanie Ehrentraut, Ute Bank, Aindrila Biswas, Caio Andreeta Figueiredo, Oliver Hölsken, Henning Peter Düsedau, Vladyslava Dovhan, Laura Knop, Jacqueline Thode, Silvina Romero-Suárez, Carmen Infante Duarte, Jason Gigley, Chiara Romagnani, Andreas Diefenbach, Christoph S N Klose, Thomas Schüler, Ildiko Rita Dunay
Cerebral infections are restrained by a complex interplay of tissue-resident and recruited peripheral immune cells. Whether innate lymphoid cells (ILCs) are involved in the orchestration of the neuroinflammatory dynamics is not fully understood. Here, we demonstrate that ILCs accumulate in the cerebral parenchyma, the choroid plexus, and the meninges in the onset of cerebral Toxoplasma gondii infection. Antibody-mediated depletion of conventional natural killer (cNK) cells and ILC1s in the early stage of infection results in diminished cytokine and chemokine expression and increased cerebral parasite burden...
March 29, 2022: Cell Reports