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Jessica Brann

Jessica L Calvi, Frances R Chen, Victoria Brann Benson, Eleanor Brindle, Matt Bristow, Alpana De, Sonja Entringer, Helen Findlay, Christine Heim, Eric A Hodges, Heiko Klawitter, Sonia Lupien, Holly M Rus, Jitske Tiemensma, Silvanna Verlezza, Claire-Dominique Walker, Douglas A Granger
OBJECTIVE: Hundreds of scientific publications are produced annually that involve the measurement of cortisol in saliva. Intra- and inter-laboratory variation in salivary cortisol results has the potential to contribute to cross-study inconsistencies in findings, and the perception that salivary cortisol results are unreliable. This study rigorously estimates sources of measurement variability in the assay of salivary cortisol within and between established international academic-based laboratories that specialize in saliva analyses...
September 13, 2017: BMC Research Notes
Jessica H Brann, Deandrea P Ellis, Benson S Ku, Eleonora F Spinazzi, Stuart Firestein
While the capacity of the olfactory epithelium (OE) to generate sensory neurons continues into middle age in mice, it is presumed that this regenerative potential is present throughout all developmental stages. However, little experimental evidence exists to support the idea that this regenerative capacity remains in late adulthood, and questions about the functionality of neurons born at these late stages remain unanswered. Here, we extend our previous work in the VNO to investigate basal rates of proliferation in the OE, as well as after olfactory bulbectomy (OBX), a commonly used surgical lesion...
2015: Frontiers in Neuroscience
Jessica H Brann, Stuart J Firestein
Neurogenesis continues well beyond embryonic and early postnatal ages in three areas of the nervous system. The subgranular zone supplies new neurons to the dentate gyrus of the hippocampus. The subventricular zone supplies new interneurons to the olfactory bulb, and the olfactory neuroepithelia generate new excitatory sensory neurons that send their axons to the olfactory bulb. The latter two areas are of particular interest as they contribute new neurons to both ends of a first-level circuit governing olfactory perception...
2014: Frontiers in Neuroscience
Weiguo Li, Roshini Prakash, Dhruv Chawla, Wenting Du, Sean P Didion, Jessica A Filosa, Quanguang Zhang, Darrell W Brann, Victor V Lima, Rita C Tostes, Adviye Ergul
Obesity is a risk factor for stroke, but the early effects of high-fat diet (HFD) on neurovascular function and ischemic stroke outcomes remain unclear. The goal of this study was to test the hypotheses that HFD beginning early in life 1) impairs neurovascular coupling, 2) causes cerebrovascular dysfunction, and 3) worsens short-term outcomes after cerebral ischemia. Functional hyperemia and parenchymal arteriole (PA) reactivity were measured in rats after 8 wk of HFD. The effect of HFD on basilar artery function after middle cerebral artery occlusion (MCAO) and associated O-GlcNAcylation were assessed...
June 1, 2013: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Arie S Mobley, Alex K Bryant, Marion B Richard, Jessica H Brann, Stuart J Firestein, Charles A Greer
Throughout life the subventricular zone (SVZ) is a source of new olfactory bulb (OB) interneurons. From the SVZ, neuroblasts migrate tangentially through the rostral migratory stream (RMS), a restricted route approximately 5 mm long in mice, reaching the OB within 10-14 days. Within the OB, neuroblasts migrate radially to the granule and glomerular layers where they differentiate into granule and periglomerular (PG) cells and integrate into existing synaptic circuits. SVZ neurogenesis decreases with age, and might be a factor in age-related olfactory deficits...
July 2013: Neurobiology of Aging
Jessica H Brann, Stuart Firestein
During normal and diseased aging, it is thought the capacity for tissue regeneration and repair in neuronal tissues diminishes. In the peripheral olfactory system, stem cell reservoirs permit regeneration of olfactory and vomeronasal sensory neurons, a unique capacity among neurons. Following injury, a large number of new neurons can be regenerated in a young animal. However, it is unknown whether this capacity for renewal exists in aged proliferative populations. Here, we report that neuronal replacement-associated proliferation continues in the vomeronasal organ of aged (18-24 months) mice...
November 17, 2010: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Thomas G Mast, Jessica H Brann, Debra A Fadool
BACKGROUND: The signal transduction cascade operational in the vomeronasal organ (VNO) of the olfactory system detects odorants important for prey localization, mating, and social recognition. While the protein machinery transducing these external cues has been individually well characterized, little attention has been paid to the role of protein-protein interactions among these molecules. Development of an in vitro expression system for the transient receptor potential 2 channel (TRPC2), which establishes the first electrical signal in the pheromone transduction pathway, led to the discovery of two protein partners that couple with the channel in the native VNO...
May 21, 2010: BMC Neuroscience
Alexander T Chesler, Claire E Le Pichon, Jessica H Brann, Ricardo C Araneda, Dong-Jing Zou, Stuart Firestein
Neurogenesis persists in the olfactory system throughout life. The mechanisms of how new neurons are generated, how they integrate into circuits, and their role in coding remain mysteries. Here we report a technique that will greatly facilitate research into these questions. We found that electroporation can be used to robustly and selectively label progenitors in the Subventicular Zone. The approach was performed postnatally, without surgery, and with near 100% success rates. Labeling was found in all classes of interneurons in the olfactory bulb, persisted to adulthood and had no adverse effects...
2008: PloS One
Jessica H Brann, Shari R Saideman, Matthew T Valley, Denise Wiedl
No abstract text is available yet for this article.
February 7, 2007: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Juan M Dominguez, Jessica H Brann, Mario Gil, Elaine M Hull
Nitric oxide in the medial preoptic area (MPOA) is important for the expression and sensitization of male sexual behavior. In this article, the authors report that repeated sexual experience (mating for 2 hr on each of 3 days) increased levels of nitric oxide synthase (NOS) in the MPOA of male rats, regardless of whether they mated on the day they were given an overdose of sodium phenobarbital. This effect resulted from the previous experience and not acute mating, as NOS was not increased 2 hr after the first mating in previously naive males...
December 2006: Behavioral Neuroscience
Jessica H Brann, Debra A Fadool
The mammalian signal transduction apparatus utilized by vomeronasal sensory neurons (VSNs) in the vomeronasal organ (VNO) has been richly explored, while that of reptiles, and in particular, the stinkpot or musk turtle Sternotherus odoratus, is less understood. Given that the turtle's well-known reproductive and mating behaviors are governed by chemical communication, 247 patch-clamp recordings were made from male and female S. odoratus VSNs to study the chemosignal-activated properties as well as the second-messenger system underlying the receptor potential...
May 2006: Journal of Experimental Biology
Antonieta Labra, Jessica H Brann, Debra A Fadool
Liolaemus lizards were explored to ascertain whether they would make an amenable model to study single-cell electrophysiology of neurons in the vomeronasal organ (VNO). Despite a rich array of chemosensory-related behaviors chronicled for this genus, no anatomical or functional data exist for the VNO, the organ mediating these types of behaviors. Two Liolaemus species (L. bellii and L. nigroviridis) were collected in Central Chile in the Farellones Mountains and transported to the United States. Lizards were subjected to hypothermia and then a lethal injection of sodium pentabarbitol prior to all experiments described in the following text...
October 2005: Journal of Neurophysiology
Albert I Farbman, Jessica H Brann, Alexander Rozenblat, M William Rochlin, Elke Weiler, Mitra Bhattacharyya
Individual neurons dissected from immunohistochemically stained paraffin sections of the developing rat geniculate (VIIth cranial) ganglion were assayed for their content of mRNA of the neurotrophin receptor genes, p75 , trkA , trkB and trkC. Fetal and postnatal rats, from the 13th embryonic day (E13) until the 20th postnatal day (P20), were used. Single cells were subjected to RNA amplification, followed by treatment with reverse transcriptase and DNA amplification by the polymerase chain reaction (PCR). The identity of the PCR products was verified by subcloning and sequencing...
May 2004: Journal of Neurocytology
Jessica H Brann, John C Dennis, Edward E Morrison, Debra A Fadool
The vomeronasal organ (VNO) is the receptor portion of the accessory olfactory system and transduces chemical cues that identify social hierarchy, reproductive status, conspecifics and prey. Signal transduction in VNO neurons is apparently accomplished via an inositol 1,4,5-trisphosphate (IP3)-activated calcium conductance that includes a different set of G proteins than those identified in vertebrate olfactory sensory neurons. We used immunohistochemical (IHC) and SDS-PAGE/western analysis to localize three IP3 receptors (IP3R) in the rat VNO epithelium...
December 2002: Journal of Neurochemistry
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