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https://www.readbyqxmd.com/read/28800504/survival-outcomes-and-patterns-of-failure-in-women-with-stage-iiic2-endometrial-carcinoma
#1
Joon K Lee, Meredith Mahan, Rabbie K Hanna, Mohamed A Elshaikh
OBJECTIVES: Para-aortic lymph node involvement in women with endometrial carcinoma (EC) is a poor prognostic factor. Many studies have included women with stage IIIC2 in cohorts of patients with advanced stage disease. The aim of this study was to analyze survival outcomes and patterns of failure in women with solely stage IIIC2 EC. METHODS: We identified women with FIGO stage IIIC2 EC who underwent surgical staging at our institution. In addition to descriptive analyses of patient demographics, tumor characteristics, and adjuvant treatment received, univariate log-rank analyses and Cox regression multivariate analyses (MVA) were performed to identify predictors of recurrence-free (RFS), disease-specific (DSS) and overall survival (OS)...
August 2, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28789755/measuring-resilience-in-two-generations-psychometric-properties-of-available-instruments
#2
Marlene Z Cohen, Kevin A Kupzyk, Lyn M Holley, Rabbi Mendel Katzman
BACKGROUND AND PURPOSE: This study examines measures of resilience to identify the best available measure for future research to assess efficacy of a low-cost intervention that enhances resilience of older adults and youth (i.e., intergenerational transfer of ethnic culture). METHODS: Scanning the literature produced no obvious choice; 3 measures showed promise: the Wagnild-Young Resilience Scale, Windle-Markland-Woods Psychological Resilience Scale, and the Connor-Davidson Resilience Scale (CD-RISC); 200 ethnicityalike older adults and 192 youths completed all three scales...
August 1, 2017: Journal of Nursing Measurement
https://www.readbyqxmd.com/read/28742101/urban-rural-differences-in-disability-free-life-expectancy-in-bangladesh-using-the-2010-hies-data
#3
Md Shariful Islam, Md Ismail Tareque, Md Nazrul Islam Mondal, Ahbab Mohammad Fazle Rabbi, Hafiz T A Khan, Sharifa Begum
BACKGROUND: Research on health expectancy has been carried out in Bangladesh but none of it has examined the differences in Disability-Free Life Expectancy (DFLE) between urban and rural setting in context of rapid urbanization of Bangladesh in past decades. OBJECTIVES: The present study aims to estimate DFLE for people of all ages living in urban and rural areas in Bangladesh, and to examine the differences in DFLE between these two areas. METHODS: Data from the Sample Vital Registration System 2010 and the Bangladesh Household Income and Expenditure Survey (HIES) 2010 were used in this study...
2017: PloS One
https://www.readbyqxmd.com/read/28597684/protection-against-shigellosis-caused-by-shigella-dysenteriae-serotype-4-in-guinea-pigs-using-escherichia-albertii-dm104-as-a-live-vaccine-candidate-strain
#4
Fatema Moni Chowdhury, Mohammed Ziaur Rahman, Md Murshed Hasan Sarkar, Fazle Rabbi, Sirajul Islam Khan, Chowdhury Rafiqul Ahsan, Nils-Kåre Birkeland
Recently, we reported the induction of protective immunity by environmental Escherichia albertii strain DM104 against Shigella dysenteriae in guinea pig model. In this study, we assessed three different immunization routes, such as intranasal, oral, and intrarectal routes, and revealed differences in immune responses by measuring both the serum IgG and mucosal IgA antibody titers. Protective efficacy of different routes of immunization was also determined by challenging immunized guinea pigs against live S...
June 9, 2017: Acta Microbiologica et Immunologica Hungarica
https://www.readbyqxmd.com/read/28554075/association-of-tp53-codon-72-and-cdh1-genetic-polymorphisms-with-colorectal-cancer-risk-in-bangladeshi-population
#5
Sanzana Fareen Rivu, Mohd Nazmul Hasan Apu, Samia Shabnaz, Noor Ahmed Nahid, Md Reazul Islam, Mir Md Abdullah Al-Mamun, Zabun Nahar, Sikder Nahidul Islam Rabbi, Maizbha Uddin Ahmed, Mohammad Safiqul Islam, Abul Hasnat
Till now no pharmacogenetic study of TP53 codon 72 (Arg72Pro) and CDH1 rs16260 (-160C<A) genes has been reported on Bangladeshi population relating those with colorectal cancer. So the aim of the study is to determine whether there is an elevated risk of colorectal cancer development with TP53 codon 72 and CDH1 rs16260 genetic polymorphism in Bangladeshi population for the first time. To investigate the association of these two SNPs, we conducted a case-control study with 288 colorectal cancer patients and 295 healthy volunteers by using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method...
May 26, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28478952/antioxidant-cytotoxic-and-antineoplastic-effects-of-carissa-carandas-linn-leaves
#6
Marina Khatun, M Rowshanul Habib, M Ahasanur Rabbi, Ruhul Amin, M Farhadul Islam, M Nurujjaman, M Rezaul Karim, M Habibur Rahman
For scientific clarification of some traditional uses, this study was designed to explore the antioxidant, cytotoxic and antineoplastic properties of leaf extract of Carissa carandas Linn., a traditional medicinal plant of Bangladesh. The methanol extract of Carissa carandas leaves (MELC) was applied on DPPH and ABTS experiments to determine its antioxidant activity. In vitro the cytotoxic effect of MELC was evaluated against colonic adenocarcinoma cell lines (SW-480 and SW-48) whereas in vivo its antineoplastic property was tested against Ehrlich ascites carcinoma (EAC)...
May 3, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28471614/jewish-medical-ethics
#7
Shimon M Glick
Jewish medical ethics is a term coined by the late Lord Rabbi Immanuel Jacobovits in the mid-20th century. Its principles and emphases differ in some significant ways from the currently accepted axioms in Western secular ethics. The emphasis is lesser on autonomy and more on the value of human life and on communitarianism. The Israel Patient's Rights Law reflects these differences from the Western norms.
October 2016: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28467424/an-image-processing-and-analysis-tool-for-identifying-and-analysing-complex-plant-root-systems-in-3d-soil-using-non-destructive-analysis-root1
#8
Richard J Flavel, Chris N Guppy, Sheikh M R Rabbi, Iain M Young
The objective of this study was to develop a flexible and free image processing and analysis solution, based on the Public Domain ImageJ platform, for the segmentation and analysis of complex biological plant root systems in soil from x-ray tomography 3D images. Contrasting root architectures from wheat, barley and chickpea root systems were grown in soil and scanned using a high resolution micro-tomography system. A macro (Root1) was developed that reliably identified with good to high accuracy complex root systems (10% overestimation for chickpea, 1% underestimation for wheat, 8% underestimation for barley) and provided analysis of root length and angle...
2017: PloS One
https://www.readbyqxmd.com/read/28461165/antitumor-properties-of-a-methyl-%C3%AE-d-galactopyranoside-specific-lectin-from-kaempferia-rotunda-against-ehrlich-ascites-carcinoma-cells
#9
Fazle Rabbi Shakil Ahmed, Ruhul Amin, Imtiaj Hasan, A K M Asaduzzaman, Syed Rashel Kabir
A lectin was isolated from the tuberous rhizome of Keampferia rotunda by using different chromatographic methods with the molecular weight of 21±1kDa. The lectin contained highest percentage of leucine and lowest percentage of tryptophan residues as determined by LC-MS. The lectin agglutinated mice and human erythrocytes and the hemagglutination activity was inhibited by Methyl-β-d-galactopyranoside. The lectin did not lose its activity in the presence of urea but the activity abolished completely when treated with EDTA...
September 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28416819/cassava-haplotype-map-highlights-fixation-of-deleterious-mutations-during-clonal-propagation
#10
Punna Ramu, Williams Esuma, Robert Kawuki, Ismail Y Rabbi, Chiedozie Egesi, Jessen V Bredeson, Rebecca S Bart, Janu Verma, Edward S Buckler, Fei Lu
Cassava (Manihot esculenta Crantz) is an important staple food crop in Africa and South America; however, ubiquitous deleterious mutations may severely decrease its fitness. To evaluate these deleterious mutations, we constructed a cassava haplotype map through deep sequencing 241 diverse accessions and identified >28 million segregating variants. We found that (i) although domestication has modified starch and ketone metabolism pathways to allow for human consumption, the concomitant bottleneck and clonal propagation have resulted in a large proportion of fixed deleterious amino acid changes, increased the number of deleterious alleles by 26%, and shifted the mutational burden toward common variants; (ii) deleterious mutations have been ineffectively purged, owing to limited recombination in the cassava genome; (iii) recent breeding efforts have maintained yield by masking the most damaging recessive mutations in the heterozygous state but have been unable to purge the mutation burden; such purging should be a key target in future cassava breeding...
June 2017: Nature Genetics
https://www.readbyqxmd.com/read/28380723/social-workers-attempts-to-navigate-among-the-elderly-their-families-and-foreign-home-care-workers-in-the-haredi-community
#11
Anat Freund, Tova Band-Winterstein
BACKGROUND: The study's aim is to examine social workers' experience in facilitating the integration of foreign home care workers (FHCWs) into the ultraorthodox Jewish (UOJ) community for the purpose of treating older adults. METHOD: Using the qualitative-phenomenological approach, semistructured, in-depth interviews were conducted with 18 social workers in daily contact with UOJ older adult clients in the process of integrating FHCWs. RESULTS: Data analysis revealed three central themes-integrating FHCWs into the aging UOJ family: barriers and challenges in the interaction between the two worlds; "even the rabbi has a FHCW": changing trends in caring for older adults; and the social worker as mediator and facilitator of a successful relationship...
February 1, 2017: Journal of Applied Gerontology: the Official Journal of the Southern Gerontological Society
https://www.readbyqxmd.com/read/28270154/pandemics-pathogenicity-and-changing-molecular-epidemiology-of-cholera-in-the-era-of-global-warming
#12
REVIEW
Fazle Rabbi Chowdhury, Zannatun Nur, Nazia Hassan, Lorenz von Seidlein, Susanna Dunachie
BACKGROUND: Vibrio cholerae, a Gram-negative, non-spore forming curved rod is found in diverse aquatic ecosystems around the planet. It is classified according to its major surface antigen into around 206 serogroups, of which O1 and O139 cause epidemic cholera. A recent spatial modelling technique estimated that around 2.86 million cholera cases occur globally every year, and of them approximately 95,000 die. About 1.3 billion people are currently at risk of infection from cholera. Meta-analysis and mathematical modelling have demonstrated that due to global warming the burden of vector-borne diseases like malaria, leishmaniasis, meningococcal meningitis, viral encephalitis, dengue and chikungunya will increase in the coming years in the tropics and beyond...
March 7, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28259548/seroprevalence-of-five-neglected-parasitic-diseases-among-immigrants-accessing-five-infectious-and-tropical-diseases-units-in-italy-a-cross-sectional-study
#13
G Martelli, C Di Girolamo, L Zammarchi, A Angheben, M Morandi, S Tais, M Degani, I El Hamad, S Caligaris, A Ciannameo, E Grilli, L Urbinati, G B Monteiro, C Scarcella, N Petrosillo, M Digaetano, L Rabbi, N Bazzanini, F Cacciatore, B L Marta, M L Moro, A Bartoloni, P Viale, G Verucchi
OBJECTIVE: This multicentre cross-sectional study aims to estimate the prevalence of five neglected tropical diseases (Chagas disease, filariasis, schistosomiasis, strongyloidiasis and toxocariasis) among immigrants accessing health care facilities in five Italian cities (Bologna, Brescia, Florence, Rome, Verona). METHODS: Individuals underwent a different set of serological tests, according to country of origin and presence of eosinophilia. Seropositive patients were treated and further followed up...
March 1, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28225446/adjuvant-external-radiation-impacts-outcome-of-pelvis-limited-stage-iii-endometrial-carcinoma-a-multi-institutional-study
#14
Kevin Albuquerque, Michael Folkert, Jyoti Mayadev, Alana Christie, Margaret R Liotta, Christa Nagel, Parag Sevak, Matthew M Harkenrider, Jayanthi S Lea, Rabbie K Hanna, William C Small, David S Miller, Xian-Jin Xie, Ronald K Potkul, Mohamed A Elshaikh
BACKGROUND: Adjuvant therapy choice for women with FIGO stage III endometrial carcinoma (EC) is controversial. We investigate the comparative benefit of adjuvant chemotherapy (CT) alone, radiation therapy alone (RT) or in combination (chemotherapy and radiation therapy [CRT]) with respect to recurrence-free survival (RFS) and overall survival (OS) in women with pelvis-limited (PL) EC (stage IIIA, IIIB, and IIIC1). MATERIALS AND METHODS: A multi-institutional database of 270 surgically staged women with PLEC was analyzed...
February 20, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28159465/a-comparison-of-sentinel-lymph-node-biopsy-to-lymphadenectomy-for-endometrial-cancer-staging-fires-trial-a-multicentre-prospective-cohort-study
#15
MULTICENTER STUDY
Emma C Rossi, Lynn D Kowalski, Jennifer Scalici, Leigh Cantrell, Kevin Schuler, Rabbie K Hanna, Michael Method, Melissa Ade, Anastasia Ivanova, John F Boggess
BACKGROUND: Sentinel-lymph-node mapping has been advocated as an alternative staging technique for endometrial cancer. The aim of this study was to measure the sensitivity and negative predictive value of sentinel-lymph-node mapping compared with the gold standard of complete lymphadenectomy in detecting metastatic disease for endometrial cancer. METHODS: In the FIRES multicentre, prospective, cohort study patients with clinical stage 1 endometrial cancer of all histologies and grades undergoing robotic staging were eligible for study inclusion...
March 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28130607/what-do-non-clergy-spiritual-care-providers-contribute-to-end-of-life-care-in-israel-a-qualitative-study
#16
Michal Pagis, Orly Tal, Wendy Cadge
Spiritual care is an increasingly important component of end of life care. As it emerges in Israel, it is intentionally built on a nonclerical model. Based on interviews with spiritual care providers in Israel, we find that they help patients and families talk about death and say goodbyes. They encourage the wrapping up of unfinished business, offer diverse cultural resources that can provide meaning, and use presence and touch to produce connection. As spiritual care emerges in Israel, providers are working with patients at the end of life in ways they see as quite distinct from rabbis...
January 27, 2017: Journal of Religion and Health
https://www.readbyqxmd.com/read/28118169/the-k-technique-a-novel-technique-for-laparoscopic-apical-suspension-using-barbed-sutures
#17
Tarek Khalife, Rabbie K Hanna
OBJECTIVES: Hysterectomy is among the most common gynecologic procedures performed for women, second only to cesarean sections, and the proportion of it performed laparoscopically continues to increase. Addressing apical support at the time of the hysterectomy is crucial to minimizing the risk of posthysterectomy prolapse. Barriers to addressing apical support include the lack of experience in laparoscopic suturing and knot tying that require advanced skills and dexterity. The K-technique is a novel modification of the uterosacral ligament suspension procedure using the knot-less barbed suture technology, rendering suturing easier and quicker to perform...
March 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/28097802/genomic-analysis-and-clinical-management-of-adolescent-cutaneous-melanoma
#18
Roy Rabbie, Mamunur Rashid, Ana M Arance, Marcelo Sánchez, Gemma Tell-Marti, Miriam Potrony, Carles Conill, Remco van Doorn, Stefan Dentro, Nelleke A Gruis, Pippa Corrie, Vivek Iyer, Carla Daniela Robles-Espinoza, Joan A Puig-Butille, Susana Puig, David J Adams
Melanoma in young children is rare; however, its incidence in adolescents and young adults is rising. We describe the clinical course of a 15-year-old female diagnosed with AJCC stage IB non-ulcerated primary melanoma, who died from metastatic disease 4 years after diagnosis despite three lines of modern systemic therapy. We also present the complete genomic profile of her tumour and compare this to a further series of 13 adolescent melanomas and 275 adult cutaneous melanomas. A somatic BRAF(V)(600E) mutation and a high mutational load equivalent to that found in adult melanoma and composed primarily of C>T mutations were observed...
May 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/27928026/azd3759-a-bbb-penetrating-egfr-inhibitor-for-the-treatment-of-egfr-mutant-nsclc-with-cns-metastases
#19
Zhenfan Yang, Qiuli Guo, Yingchun Wang, Kan Chen, Lin Zhang, Ziqiang Cheng, Yanping Xu, Xiaolu Yin, Yu Bai, Sarit Rabbie, Dong-Wan Kim, Myung-Ju Ahn, James Chih-Hsin Yang, Xiaolin Zhang
Non-small-cell lung cancer patients with activating mutations in epidermal growth factor receptor (EGFR) respond to EGFR tyrosine kinase inhibitor (TKI) treatment. Nevertheless, patients often develop central nervous system (CNS) metastases during treatment, even when their extracranial tumors are still under control. In the absence of effective options, much higher doses of EGFR TKIs have been attempted clinically, with the goal of achieving high enough drug concentrations within the CNS. Although limited tumor responses have been observed with this approach, the toxicities outside the CNS have been too high to tolerate...
December 7, 2016: Science Translational Medicine
https://www.readbyqxmd.com/read/27898832/genome-wide-association-and-prediction-reveals-genetic-architecture-of-cassava-mosaic-disease-resistance-and-prospects-for-rapid-genetic-improvement
#20
Marnin D Wolfe, Ismail Y Rabbi, Chiedozie Egesi, Martha Hamblin, Robert Kawuki, Peter Kulakow, Roberto Lozano, Dunia Pino Del Carpio, Punna Ramu, Jean-Luc Jannink
C ( Crantz) is a crucial, under-researched crop feeding millions worldwide, especially in Africa. Cassava mosaic disease (CMD) has plagued production in Africa for over a century. Biparental mapping studies suggest primarily a single major gene mediates resistance. To investigate this genetic architecture, we conducted the first genome-wide association mapping study in cassava with up to 6128 genotyping-by-sequenced African breeding lines and 42,113 reference genome-mapped single-nucleotide polymorphism (SNP) markers...
July 2016: Plant Genome
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