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https://www.readbyqxmd.com/read/28478952/antioxidant-cytotoxic-and-antineoplastic-effects-of-carissa-carandas-linn-leaves
#1
Marina Khatun, M Rowshanul Habib, M Ahasanur Rabbi, Ruhul Amin, M Farhadul Islam, M Nurujjaman, M Rezaul Karim, M Habibur Rahman
For scientific clarification of some traditional uses, this study was designed to explore the antioxidant, cytotoxic and antineoplastic properties of leaf extract of Carissa carandas Linn., a traditional medicinal plant of Bangladesh. The methanol extract of Carissa carandas leaves (MELC) was applied on DPPH and ABTS experiments to determine its antioxidant activity. In vitro the cytotoxic effect of MELC was evaluated against colonic adenocarcinoma cell lines (SW-480 and SW-48) whereas in vivo its antineoplastic property was tested against Ehrlich ascites carcinoma (EAC)...
May 3, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28471614/jewish-medical-ethics
#2
Shimon M Glick
Jewish medical ethics is a term coined by the late Lord Rabbi Immanuel Jacobovits in the mid-20th century. Its principles and emphases differ in some significant ways from the currently accepted axioms in Western secular ethics. The emphasis is lesser on autonomy and more on the value of human life and on communitarianism. The Israel Patient's Rights Law reflects these differences from the Western norms.
October 2016: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28467424/an-image-processing-and-analysis-tool-for-identifying-and-analysing-complex-plant-root-systems-in-3d-soil-using-non-destructive-analysis-root1
#3
Richard J Flavel, Chris N Guppy, Sheikh M R Rabbi, Iain M Young
The objective of this study was to develop a flexible and free image processing and analysis solution, based on the Public Domain ImageJ platform, for the segmentation and analysis of complex biological plant root systems in soil from x-ray tomography 3D images. Contrasting root architectures from wheat, barley and chickpea root systems were grown in soil and scanned using a high resolution micro-tomography system. A macro (Root1) was developed that reliably identified with good to high accuracy complex root systems (10% overestimation for chickpea, 1% underestimation for wheat, 8% underestimation for barley) and provided analysis of root length and angle...
2017: PloS One
https://www.readbyqxmd.com/read/28461165/antitumor-properties-of-a-methyl-%C3%AE-d-galactopyranoside-specific-lectin-from-kaempferia-rotunda-against-ehrlich-ascites-carcinoma-cells
#4
Fazle Rabbi Shakil Ahmed, Ruhul Amin, Imtiaj Hasan, A K M Asaduzzaman, Syed Rashel Kabir
A lectin was isolated from the tuberous rhizome of Keampferia rotunda by using different chromatographic methods with the molecular weight of 21±1kDa. The lectin contained highest percentage of leucine and lowest percentage of tryptophan residues as determined by LC-MS. The lectin agglutinated mice and human erythrocytes and the hemagglutination activity was inhibited by Methyl-β-d-galactopyranoside. The lectin did not lose its activity in the presence of urea but the activity abolished completely when treated with EDTA...
April 28, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28416819/cassava-haplotype-map-highlights-fixation-of-deleterious-mutations-during-clonal-propagation
#5
Punna Ramu, Williams Esuma, Robert Kawuki, Ismail Y Rabbi, Chiedozie Egesi, Jessen V Bredeson, Rebecca S Bart, Janu Verma, Edward S Buckler, Fei Lu
Cassava (Manihot esculenta Crantz) is an important staple food crop in Africa and South America; however, ubiquitous deleterious mutations may severely decrease its fitness. To evaluate these deleterious mutations, we constructed a cassava haplotype map through deep sequencing 241 diverse accessions and identified >28 million segregating variants. We found that (i) although domestication has modified starch and ketone metabolism pathways to allow for human consumption, the concomitant bottleneck and clonal propagation have resulted in a large proportion of fixed deleterious amino acid changes, increased the number of deleterious alleles by 26%, and shifted the mutational burden toward common variants; (ii) deleterious mutations have been ineffectively purged, owing to limited recombination in the cassava genome; (iii) recent breeding efforts have maintained yield by masking the most damaging recessive mutations in the heterozygous state but have been unable to purge the mutation burden; such purging should be a key target in future cassava breeding...
June 2017: Nature Genetics
https://www.readbyqxmd.com/read/28380723/social-workers-attempts-to-navigate-among-the-elderly-their-families-and-foreign-home-care-workers-in-the-haredi-community
#6
Anat Freund, Tova Band-Winterstein
BACKGROUND: The study's aim is to examine social workers' experience in facilitating the integration of foreign home care workers (FHCWs) into the ultraorthodox Jewish (UOJ) community for the purpose of treating older adults. METHOD: Using the qualitative-phenomenological approach, semistructured, in-depth interviews were conducted with 18 social workers in daily contact with UOJ older adult clients in the process of integrating FHCWs. RESULTS: Data analysis revealed three central themes-integrating FHCWs into the aging UOJ family: barriers and challenges in the interaction between the two worlds; "even the rabbi has a FHCW": changing trends in caring for older adults; and the social worker as mediator and facilitator of a successful relationship...
February 1, 2017: Journal of Applied Gerontology: the Official Journal of the Southern Gerontological Society
https://www.readbyqxmd.com/read/28270154/pandemics-pathogenicity-and-changing-molecular-epidemiology-of-cholera-in-the-era-of-global-warming
#7
REVIEW
Fazle Rabbi Chowdhury, Zannatun Nur, Nazia Hassan, Lorenz von Seidlein, Susanna Dunachie
BACKGROUND: Vibrio cholerae, a Gram-negative, non-spore forming curved rod is found in diverse aquatic ecosystems around the planet. It is classified according to its major surface antigen into around 206 serogroups, of which O1 and O139 cause epidemic cholera. A recent spatial modelling technique estimated that around 2.86 million cholera cases occur globally every year, and of them approximately 95,000 die. About 1.3 billion people are currently at risk of infection from cholera. Meta-analysis and mathematical modelling have demonstrated that due to global warming the burden of vector-borne diseases like malaria, leishmaniasis, meningococcal meningitis, viral encephalitis, dengue and chikungunya will increase in the coming years in the tropics and beyond...
March 7, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28259548/seroprevalence-of-five-neglected-parasitic-diseases-among-immigrants-accessing-five-infectious-and-tropical-diseases-units-in-italy-a-cross-sectional-study
#8
G Martelli, C Di Girolamo, L Zammarchi, A Angheben, M Morandi, S Tais, M Degani, I El Hamad, S Caligaris, A Ciannameo, E Grilli, L Urbinati, G B Monteiro, C Scarcella, N Petrosillo, M Digaetano, L Rabbi, N Bazzanini, F Cacciatore, B L Marta, M L Moro, A Bartoloni, P Viale, G Verucchi
OBJECTIVE: This multicentre cross-sectional study aims to estimate the prevalence of five neglected tropical diseases (Chagas disease, filariasis, schistosomiasis, strongyloidiasis and toxocariasis) among immigrants accessing health care facilities in five Italian cities (Bologna, Brescia, Florence, Rome, Verona). METHODS: Individuals underwent a different set of serological tests, according to country of origin and presence of eosinophilia. Seropositive patients were treated and further followed up...
March 1, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28225446/adjuvant-external-radiation-impacts-outcome-of-pelvis-limited-stage-iii-endometrial-carcinoma-a-multi-institutional-study
#9
Kevin Albuquerque, Michael Folkert, Jyoti Mayadev, Alana Christie, Margaret R Liotta, Christa Nagel, Parag Sevak, Matthew M Harkenrider, Jayanthi S Lea, Rabbie K Hanna, William C Small, David S Miller, Xian-Jin Xie, Ronald K Potkul, Mohamed A Elshaikh
BACKGROUND: Adjuvant therapy choice for women with FIGO stage III endometrial carcinoma (EC) is controversial. We investigate the comparative benefit of adjuvant chemotherapy (CT) alone, radiation therapy alone (RT) or in combination (chemotherapy and radiation therapy [CRT]) with respect to recurrence-free survival (RFS) and overall survival (OS) in women with pelvis-limited (PL) EC (stage IIIA, IIIB, and IIIC1). MATERIALS AND METHODS: A multi-institutional database of 270 surgically staged women with PLEC was analyzed...
February 20, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28159465/a-comparison-of-sentinel-lymph-node-biopsy-to-lymphadenectomy-for-endometrial-cancer-staging-fires-trial-a-multicentre-prospective-cohort-study
#10
Emma C Rossi, Lynn D Kowalski, Jennifer Scalici, Leigh Cantrell, Kevin Schuler, Rabbie K Hanna, Michael Method, Melissa Ade, Anastasia Ivanova, John F Boggess
BACKGROUND: Sentinel-lymph-node mapping has been advocated as an alternative staging technique for endometrial cancer. The aim of this study was to measure the sensitivity and negative predictive value of sentinel-lymph-node mapping compared with the gold standard of complete lymphadenectomy in detecting metastatic disease for endometrial cancer. METHODS: In the FIRES multicentre, prospective, cohort study patients with clinical stage 1 endometrial cancer of all histologies and grades undergoing robotic staging were eligible for study inclusion...
March 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28130607/what-do-non-clergy-spiritual-care-providers-contribute-to-end-of-life-care-in-israel-a-qualitative-study
#11
Michal Pagis, Orly Tal, Wendy Cadge
Spiritual care is an increasingly important component of end of life care. As it emerges in Israel, it is intentionally built on a nonclerical model. Based on interviews with spiritual care providers in Israel, we find that they help patients and families talk about death and say goodbyes. They encourage the wrapping up of unfinished business, offer diverse cultural resources that can provide meaning, and use presence and touch to produce connection. As spiritual care emerges in Israel, providers are working with patients at the end of life in ways they see as quite distinct from rabbis...
January 27, 2017: Journal of Religion and Health
https://www.readbyqxmd.com/read/28118169/the-k-technique-a-novel-technique-for-laparoscopic-apical-suspension-using-barbed-sutures
#12
Tarek Khalife, Rabbie K Hanna
OBJECTIVES: Hysterectomy is among the most common gynecologic procedures performed for women, second only to cesarean sections, and the proportion of it performed laparoscopically continues to increase. Addressing apical support at the time of the hysterectomy is crucial to minimizing the risk of posthysterectomy prolapse. Barriers to addressing apical support include the lack of experience in laparoscopic suturing and knot tying that require advanced skills and dexterity. The K-technique is a novel modification of the uterosacral ligament suspension procedure using the knot-less barbed suture technology, rendering suturing easier and quicker to perform...
March 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/28097802/genomic-analysis-and-clinical-management-of-adolescent-cutaneous-melanoma
#13
Roy Rabbie, Mamunur Rashid, Ana M Arance, Marcelo Sánchez, Gemma Tell-Marti, Miriam Potrony, Carles Conill, Remco van Doorn, Stefan Dentro, Nelleke A Gruis, Pippa Corrie, Vivek Iyer, Carla Daniela Robles-Espinoza, Joan A Puig-Butille, Susana Puig, David J Adams
Melanoma in young children is rare; however, its incidence in adolescents and young adults is rising. We describe the clinical course of a 15-year-old female diagnosed with AJCC stage IB non-ulcerated primary melanoma, who died from metastatic disease 4 years after diagnosis despite three lines of modern systemic therapy. We also present the complete genomic profile of her tumour and compare this to a further series of 13 adolescent melanomas and 275 adult cutaneous melanomas. A somatic BRAF(V)(600E) mutation and a high mutational load equivalent to that found in adult melanoma and composed primarily of C>T mutations were observed...
May 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/27928026/azd3759-a-bbb-penetrating-egfr-inhibitor-for-the-treatment-of-egfr-mutant-nsclc-with-cns-metastases
#14
Zhenfan Yang, Qiuli Guo, Yingchun Wang, Kan Chen, Lin Zhang, Ziqiang Cheng, Yanping Xu, Xiaolu Yin, Yu Bai, Sarit Rabbie, Dong-Wan Kim, Myung-Ju Ahn, James Chih-Hsin Yang, Xiaolin Zhang
Non-small-cell lung cancer patients with activating mutations in epidermal growth factor receptor (EGFR) respond to EGFR tyrosine kinase inhibitor (TKI) treatment. Nevertheless, patients often develop central nervous system (CNS) metastases during treatment, even when their extracranial tumors are still under control. In the absence of effective options, much higher doses of EGFR TKIs have been attempted clinically, with the goal of achieving high enough drug concentrations within the CNS. Although limited tumor responses have been observed with this approach, the toxicities outside the CNS have been too high to tolerate...
December 7, 2016: Science Translational Medicine
https://www.readbyqxmd.com/read/27898832/genome-wide-association-and-prediction-reveals-genetic-architecture-of-cassava-mosaic-disease-resistance-and-prospects-for-rapid-genetic-improvement
#15
Marnin D Wolfe, Ismail Y Rabbi, Chiedozie Egesi, Martha Hamblin, Robert Kawuki, Peter Kulakow, Roberto Lozano, Dunia Pino Del Carpio, Punna Ramu, Jean-Luc Jannink
C ( Crantz) is a crucial, under-researched crop feeding millions worldwide, especially in Africa. Cassava mosaic disease (CMD) has plagued production in Africa for over a century. Biparental mapping studies suggest primarily a single major gene mediates resistance. To investigate this genetic architecture, we conducted the first genome-wide association mapping study in cassava with up to 6128 genotyping-by-sequenced African breeding lines and 42,113 reference genome-mapped single-nucleotide polymorphism (SNP) markers...
July 2016: Plant Genome
https://www.readbyqxmd.com/read/27875073/orthodox-jewish-thought-leaders-insights-regarding-brca-mutations-a-descriptive-study
#16
Toby Bressler, Beth Popp
PURPOSE: To examine the factors that influence Orthodox Jewish (OJ) thought leaders' perceptions of genetic counseling and testing for BRCA mutations. The specific aims of this study were to describe (1) OJ thought leaders' views on genetic counseling and testing for BRCA mutation status and (2) insights into this high-risk faith-based minority group and their beliefs about counseling and testing for BRCA mutations. METHODS: In-depth focus groups and demographic questionnaires were used in this descriptive, qualitative study, which was performed in the cancer center of a 750-bed community teaching hospital in Brooklyn, New York...
April 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/27771558/speckle-tracking-and-speckle-content-based-composite-strain-imaging-for-solid-and-fluid-filled-lesions
#17
Md Shifat-E Rabbi, Md Kamrul Hasan
Strain imaging though for solid lesions provides an effective way for determining their pathologic condition by displaying the tissue stiffness contrast, for fluid filled lesions such an imaging is yet an open problem. In this paper, we propose a novel speckle content based strain imaging technique for visualization and classification of fluid filled lesions in elastography after automatic identification of the presence of fluid filled lesions. Speckle content based strain, defined as a function of speckle density based on the relationship between strain and speckle density, gives an indirect strain value for fluid filled lesions...
February 2017: Ultrasonics
https://www.readbyqxmd.com/read/27671183/efficacy-of-probiotics-versus-placebo-in-the-prevention-of-necrotizing-enterocolitis-in-preterm-very-low-birth-weight-infants-a-double-blind-randomized-controlled-trial
#18
Tanjina Chowdhury, Muhammad Manajjir Ali, Muhammad Monir Hossain, Jugindra Singh, Abu Noyeem Muhammad Yousuf, Fatema Yasmin, Fazle Rabbi Chowdhury
OBJECTIVE: To evaluate the efficacy of orally administered probiotics in preventing necrotizing enterocolitis (NEC) in preterm very low birth weight (VLBW) infants. STUDY DESIGN: Arandomized double blind controlled trial. PLACE AND DURATION OF STUDY: The Paediatrics Department of Sylhet M.A.G. Osmani Medical College Hospital, Sylhet Bangladesh, from July 2012 to June 2015. METHODOLOGY: Preterm (28 - 33 weeks gestation) VLBW (birth weight 1000 - 1499 g) neonates were enrolled...
September 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/27615807/physical-soil-architectural-traits-are-functionally-linked-to-carbon-decomposition-and-bacterial-diversity
#19
S M F Rabbi, H Daniel, P V Lockwood, C Macdonald, L Pereg, M Tighe, B R Wilson, I M Young
Aggregates play a key role in protecting soil organic carbon (SOC) from microbial decomposition. The objectives of this study were to investigate the influence of pore geometry on the organic carbon decomposition rate and bacterial diversity in both macro- (250-2000 μm) and micro-aggregates (53-250 μm) using field samples. Four sites of contrasting land use on Alfisols (i.e. native pasture, crop/pasture rotation, woodland) were investigated. 3D Pore geometry of the micro-aggregates and macro-aggregates were examined by X-ray computed tomography (μCT)...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27587297/marker-based-estimates-reveal-significant-non-additive-effects-in-clonally-propagated-cassava-manihot-esculenta-implications-for-the-prediction-of-total-genetic-value-and-the-selection-of-varieties
#20
Marnin D Wolfe, Peter Kulakow, Ismail Y Rabbi, Jean-Luc Jannink
In clonally propagated crops, non-additive genetic effects can be effectively exploited by the identification of superior genetic individuals as varieties. Cassava (Manihot esculenta Crantz) is a clonally propagated staple food crop that feeds hundreds of millions. We quantified the amount and nature of non-additive genetic variation for three key traits in a breeding population of cassava from sub-Saharan Africa using additive and non-additive genome-wide marker-based relationship matrices. We then assessed the accuracy of genomic prediction for total (additive plus non-additive) genetic value...
August 31, 2016: G3: Genes—Genomes—Genetics
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