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atypical gastrointestinal stromal tumor

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https://www.readbyqxmd.com/read/27738815/-new-features-in-the-2014-who-classification-of-uterine-neoplasms
#1
S F Lax
The 2014 World Health Organization (WHO) classification of uterine tumors revealed simplification of the classification by fusion of several entities and the introduction of novel entities. Among the multitude of alterations, the following are named: a simplified classification for precursor lesions of endometrial carcinoma now distinguishes between hyperplasia without atypia and atypical hyperplasia, the latter also known as endometrioid intraepithelial neoplasia (EIN). For endometrial carcinoma a differentiation is made between type 1 (endometrioid carcinoma with variants and mucinous carcinoma) and type 2 (serous and clear cell carcinoma)...
October 13, 2016: Der Pathologe
https://www.readbyqxmd.com/read/27698892/atypical-presentation-of-a-gastric-stromal-tumor-masquerading-as-a-giant-intraabdominal-cyst-a-case-report
#2
Ke-Kang Sun, Song Xu, Jinzhen Chen, Gang Liu, Xiaojun Shen, Xiaoyang Wu
Gastrointestinal stromal tumors (GISTs) are mesenchymal neoplasms that arise in the gastrointestinal tract, accounting for ~1% of gastric malignancies. The present study reports the case of a GIST of the stomach in a 75-year-old man who presented with abdominal distension and anorexia for 1 month. Gastroscopy was unremarkable. Ultrasound and computed tomography (CT) scans showed a giant intraabdominal cystic lesion of unknown origin. The lesion was initially believed to be a duplication cyst, a pancreatic pseudocyst or a liver cyst in the pre-operative diagnosis...
October 2016: Oncology Letters
https://www.readbyqxmd.com/read/26939310/leiomyosarcoma-of-the-colon
#3
Vlado Janevski, Redžep Selmani, Vesna Janevska, Liljana Spasevska, Julija Zhivadinovik
INTRODUCTION: Gastrointestinal stromal tumors are the most common mesenchymal tumors of the digestive tract. Leiomyosarcomas of the gastrointestinal tract are rare mesenchymal neoplasms which grossly and histologically resemble gastrointestinal stromal tumors. They may be differentiated from gastrointestinal stromal tumors by using immunohistochemistry and they are typically positive for a smooth muscle actin and desmin and negative for c-kit, CD34 and DOG1.1. They often express calponin and h-caldesmon...
November 2015: Medicinski Pregled
https://www.readbyqxmd.com/read/26895113/gastrointestinal-stromal-tumor-of-the-vermiform-appendix-mimicking-meckel-s-diverticulum-case-report-with-literature-review
#4
Jae Min Chun, Kyoung Hoon Lim
INTRODUCTION: Gastrointestinal stromal tumors (GISTs) of the appendix are extremely rare. To date, only 15 cases have been reported in the English literature. Here, we present a new case of an appendiceal GIST with appendicitis. PRESENTATION OF CASE: A 68-year-old man who complained of right lower abdominal tenderness underwent surgery for a cystic mass mimicking Meckel's diverticulum. Laparoscopy revealed a mass protruding from the proximal appendix with distal appendicitis...
2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/26819809/c-kit-negative-gastrointestinal-stromal-tumor-in-the-stomach
#5
Ho Seok Seo, Ji Yeon Hyeon, Ok-Ran Shin, Han Hong Lee
C-kit-negative gastrointestinal stromal tumors (GISTs) are uncommon, and there have been few reports about the diagnosis and treatment of c-kit-negative GISTs in the stomach. We report the case of a patient who was diagnosed with a huge and atypical GIST in the stomach. The GIST was completely resected and finally diagnosed as c-kit-negative GIST based on immunohistochemical staining of tumor cells, which were negative for CD117 and CD34 and positive for Discovered on GIST-1 (DOG1). C-kit-negative GISTs could be treated by complete resection and/or imatinib, which is the same treatment for c-kit-positive GISTs...
December 2015: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/26622655/c-x-c-motif-receptor-7-in-gastrointestinal-cancer
#6
Hwan-Jung Yun, Hyewon Ryu, Yoon Seok Choi, Ik-Chan Song, Deog-Yeon Jo, Samyong Kim, Hyo Jin Lee
Chemokine receptors are key mediators of normal physiology and numerous pathological conditions, including inflammation and cancer. This receptor family is an emerging target for anticancer drug development. C-X-C motif receptor 7 (CXCR7) is an atypical chemokine receptor that was first cloned from a canine cDNA library as an orphan receptor and was initially named receptor dog cDNA 1 (RDC1). Shortly after demonstrating that RDC1 binds with its ligand, stromal cell-derived factor-1α and interferon-inducible T-cell α chemoattractant, RDC1 was officially deorphanized and renamed CXCR7, as the seventh receptor in the CXC class of the chemokine receptor family...
September 2015: Oncology Letters
https://www.readbyqxmd.com/read/26585554/loss-of-h3k27-trimethylation-distinguishes-malignant-peripheral-nerve-sheath-tumors-from-histologic-mimics
#7
Inga-Marie Schaefer, Christopher Dm Fletcher, Jason L Hornick
The diagnosis of malignant peripheral nerve sheath tumor is challenging, particularly in the sporadic setting. Inactivation of the polycomb repressive complex 2 (PRC2), resulting from inactivating mutations of its constituents SUZ12 or EED1, has recently been identified in 70-90% of malignant peripheral nerve sheath tumors. Homozygous PRC2 inactivation results in loss of histone H3K27 trimethylation (H3K27me3). PRC2 inactivation promotes tumor progression and may render patients sensitive to epigenetic-based targeted therapies...
January 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/26370861/a-patient-with-an-extra-adrenal-pheochromocytoma-and-germ-line-sdhb-mutation-accompanied-by-an-atypical-meningioma
#8
Tsuguka Shiwa, Kenji Oki, Masayasu Yoneda, Koji Arihiro, Haruya Ohno, Rui Kishimoto, Nobuoki Kohno
The gene succinate dehydrogenase subunit B (SDHB) encodes a protein comprising part of the mitochondrial complex II, which links the Krebs cycle and the electron-transport chain. Heterozygous germ-line SDHB mutations causes familial pheochromocytoma-paraganglioma syndrome and has also been linked to gastrointestinal stromal tumors, as well as renal cell carcinomas. We herein report a patient with a germ-line SDHB mutation who presented with an atypical meningioma that was identified as originating from a somatic SDHB mutation...
2015: Internal Medicine
https://www.readbyqxmd.com/read/26271149/extragastrointestinal-stromal-tumor-of-lesser-omentum-a-challenging-radiological-and-histological-diagnosis
#9
Claudia Trombatore, Stefano Palmucci, Giuseppe Angelico, Enrico Vasquez, Giuseppe Petrillo, Stefano Puleo, Antonio Di Cataldo
Extragastrointestinal stromal tumors (EGISTs) are a rare subgroup of gastrointestinal stromal tumors (GISTs), arising from outside the walls of gastrointestinal tubular organs. We report a case of an EGIST of the lesser omentum that represented a diagnostic challenge. Due to its atypical radiologic findings, it was preoperatively mistaken for pedunculated hepatic hemangioma. Histopathologically, it showed epithelioid structure and c-kit negative, very uncommon for GIST. Only a few cases of EGISTs have been previously reported...
November 2015: Clinical Imaging
https://www.readbyqxmd.com/read/25931843/an-atypically-localized-gastrointestinal-stromal-tumor-a-case-report-of-pancreas-gastrointestinal-stromal-tumor
#10
Kürşat Rahmi Serin, Metin Keskin, Mine Güllüoğlu, Ali Emre
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. They can arise from any part of the tract as well as the omentum, mesentery or retroperitoneum. In this study, we present a case of a GIST originating from an extraordinary site, the pancreas. Evaluation of 30-year-old man with complaints of abdominal distension revealed a cystic, distal pancreatic lesion 13 cm in diameter. There were no intra-abdominal or distant organ metastases. The patient was operated with a diagnosis of cystic pancreas tumor, distal pancreatectomy and splenectomy was performed...
2013: Ulusal Cerrahi Dergisi
https://www.readbyqxmd.com/read/25805949/giant-gastrointestinal-stromal-tumour-of-rare-sarcomatoid-epithelioid-subtype-case-study-and-literature-review
#11
REVIEW
Gustaw Lech, Wojciech Korcz, Emilia Kowalczyk, Tomasz Guzel, Marcin Radoch, Ireneusz Wojciech Krasnodębski
Gastrointestinal stromal tumours (GISTs) are the most common mesenchymal tumours of the gastrointestinal tract, but they represent less than 3% of all gastrointestinal tract malignancies. This is a detailed case study of a 52-year-old male patient treated for very uncommon histological subtype of gastric GIST with atypical clinical presentation, asymptomatic progress and late diagnosis. The resected tumour, giant in diameters, was confirmed to represent the most rare histopathologic subtype of GISTs - sarcomatoid epithelioid GIST...
March 21, 2015: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/25768277/atypical-presentation-of-gastrointestinal-stromal-tumor-masquerading-as-a-large-duodenal-cyst-a-case-report
#12
Ameet Kumar, C K Jakhmola, Shivraj Singh Chauhan, Apoorv Singh
INTRODUCTION: Gastrointestinal stromal tumors (GIST) are solid tumors. A duodenal GIST masquerading as a cystic lesion has never been reported. We report a large duodenal cyst that finally turned out to be a GIST and was managed without a pancreaticoduodenectomy (PD). PRESENTATION OF CASE: A 55 year old lady presented with painful lump in epigastrium. A CT scan revealed a large exophytic cystic lesion from the duodenum with a small solid component. An endoscopy showed a polypoid lesion in the second part of the duodenum adjacent to what looked like a diverticulum...
2015: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/25663856/refractory-left-pleural-effusion-in-an-older-patient-atypical-presentation-of-colorectal-carcinoma
#13
Yujie Yuan, Jinning Ye, Chuangqi Chen, Wu Song, Jianbo Xu, Jianhui Chen, Yaping Xing, Yulong He
The current study reports the case of a 60-year-old male that presented with a four-month history of recurrent chest pain. Chest X-ray examination revealed a left-sided pleural effusion. A closed thoracic drainage procedure was performed, but the chest pain relapsed shortly afterwards. The pleural fluid was exudative, with no tumor cells detected. A computed tomography scan subsequently revealed a large mass located in the splenic curve of the colon, with involvement of the greater curvature of the stomach...
March 2015: Oncology Letters
https://www.readbyqxmd.com/read/25614811/gastrointestinal-stromal-tumor-gist-mistaken-for-pancreatic-pseudocyst-case-report-and-literature-review
#14
Cristiano de Assis Pereira Hansen, Fábio Freire José, Naiara Pedrassi Engracia Garcia Caluz
A 74-year-old female patient underwent a Roux-en-Y cystjejunostomy for pancreatic pseudocyst developed several melena episodes and she was surgically reappraised. The main diagnostic concern was a pancreatic cystic neoplasm. A 12 × 8.0 × 5.0 cm retro-gastric lesion was resected and pathology report indicated an unsuspected gastrointestinal stromal tumor (GIST). The report aimed to describe an atypical presentation of GIST.
October 2014: Clinical Case Reports
https://www.readbyqxmd.com/read/25591869/secondary-thrombotic-microangiopathy-in-two-patients-with-philadelphia-positive-hematological-malignancies-treated-with-imatinib-mesylate
#15
Mario Ojeda-Uribe, Sylvain Merieau, Marie Guillon, Olivier Aujoulat, Olivier Hinschberger, Jean-Claude Eisenmann, David Kenizou, Agathe Debliquis, Agnès Veyradier, François Chantrel
Drug-mediated thrombotic microangiopathy may cause life-threatening medical emergencies. Novel targeted therapies have dramatically changed the prognosis of a number of oncological diseases. Tyrosine kinase inhibitors of the Breakpoint Cluster Region-Abelson (BCR-ABL) oncoprotein are used in patients with chronic myeloid leukemia or Philadelphia chromosome-positive acute lymphoblastic leukemia. Imatinib mesylate, which was the first anti-BCR-ABL tyrosine kinase inhibitor, has demonstrated a high tolerance profile and efficacy in these patients for many years...
April 2016: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/24827382/tumor-sites-and-microscopic-indicators-are-independent-prognosis-predictors-of-gastrointestinal-stromal-tumors
#16
Yijun Qi, Wendi Zhao, Zhengguang Wang, Tuanjie Li, Xiangling Meng
Gastrointestinal stromal tumors (GISTs) are the most common among gastrointestinal mesenchymal tumors, but its prognosis has not been accurately predicted by the current risk stratification guidelines, National Institutes of Health classification. In this study, we evaluated the predictive factors for GIST prognosis in a retrospective analysis of 332 patients. The data collected included tumor sites, including the esophagus, stomach, duodenum, small intestine, and extragastrointestinal sites; tumor size; microscopic indicators for malignant tumor behavior, such as the number of dividing cells, cell necrosis, atypical morphology, and invasion into the muscular or mucous layer; and previously established immunohistochemical indicators, CD117, CD34, and discovered on GIST-1 (DOG-1)...
2014: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/24771887/gastrointestinal-stromal-tumor-gist-presenting-as-a-huge-pelvic-mass
#17
Th Lee
Gastrointestinal stromal tumors (GISTs) are rare tumors that can arise anywhere in the tubular gastrointestinal tract. These tumors occasionally present as a pelvic mass, leading to a misdiagnosis of gynecological disease. A 47-year-old woman presented with a pelvic mass measuring 30 cm in diameter and highly elevated CA-125 levels. She underwent exploratory laparotomy with resection of the pelvic mass. The mass mimicking ovarian malignancy was found in the sigmoid colon and was correctly diagnosed as a GIST at surgery...
January 2013: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/24715189/solitary-fibrous-tumor-arising-from-the-mesentery-of-adult-patients-report-of-two-cases-and-review-of-the-literature
#18
REVIEW
José Fernando Val-Bernal, Marta Mayorga, Fidel Fernández, Alejandro Parra, Juan Crespo, Manuel García-Polavieja
Solitary fibrous tumors (SFTs) represent an uncommon entity most frequently manifested in the pleura. We describe herein two new cases located in the jejunal and sigmoid mesentery incidentally found in patients aged 61 and 32 years. In a review of the literature, we have compiled 15 mesenteric SFTs including our two cases. The mean age of the patients at presentation was 51.7 years (range, 26-83 years). Most patients were males (males:females 4:1). Although occasionally these tumors were an incidental finding, the majority have been symptomatic...
2014: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/24623741/overexpression-of-mir-210-is-associated-with-sdh-related-pheochromocytomas-paragangliomas-and-gastrointestinal-stromal-tumours
#19
V H M Tsang, T Dwight, D E Benn, G Y Meyer-Rochow, A J Gill, M Sywak, S Sidhu, D Veivers, C M Sue, B G Robinson, R J Clifton-Bligh, N R Parker
miR-210 is a key regulator of response to hypoxia. Pheochromocytomas (PCs) and paragangliomas (PGLs) with germline SDHx or VHL mutations have pseudohypoxic gene expression signatures. We hypothesised that PC/PGLs containing SDHx or VHL mutations, and succinate dehydrogenase (SDH)-deficient gastrointestinal stromal tumours (GISTs), would overexpress miR-210 relative to non-SDH or -VHL-mutated counterparts. miR-210 was analysed by quantitative PCR in i) 39 PC/PGLs, according to genotype (one SDHA, five SDHB, seven VHL, three NF1, seven RET, 15 sporadic, one unknown) and pathology (18 benign, eight atypical, 11 malignant, two unknown); ii) 18 GISTs, according to SDHB immunoreactivity (nine SDH-deficient and nine SDH-proficient) and iii) two novel SDHB-mutant neurosphere cell lines...
June 2014: Endocrine-related Cancer
https://www.readbyqxmd.com/read/24518721/balloon-cell-melanoma-of-the-anal-canal-a-wolf-in-sheep-s-clothing
#20
Munita Meenu Bal, Mukta Ramadwar, Kedar Deodhar
Balloon cell melanoma (BCM) is a rare histologic variant of cutaneous malignant melanoma with exceptional reports of occurrences at non-cutaneous sites. Herein we present a case of primary amelanotic BCM of anal canal, a heretofore undescribed location. Histologically, the tumor was characterized by sheets of pale cells that bore striking resemblance to foamy macrophages. Presence of rare atypical mitoses confirmed the malignant nature of the cells. Neoplastic cells were immunoreactive for S100, Melan-A, and focally for HMB-45 while were negative for myogenic, gastrointestinal stromal tumor, epithelial and neuroendocrine markers...
October 2013: Journal of Cancer Research and Therapeutics
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