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https://www.readbyqxmd.com/read/27876126/regular-sun-exposure-benefits-health
#1
H J van der Rhee, E de Vries, J W Coebergh
Since it was discovered that UV radiation was the main environmental cause of skin cancer, primary prevention programs have been started. These programs advise to avoid exposure to sunlight. However, the question arises whether sun-shunning behaviour might have an effect on general health. During the last decades new favourable associations between sunlight and disease have been discovered. There is growing observational and experimental evidence that regular exposure to sunlight contributes to the prevention of colon-, breast-, prostate cancer, non-Hodgkin lymphoma, multiple sclerosis, hypertension and diabetes...
December 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27825568/osteoarticular-manifestations-of-celiac-disease-and-non-celiac-gluten-hypersensitivity
#2
Stéphanie Dos Santos, Frédéric Lioté
Celiac disease is a chronic inflammatory autoimmune enteropathy based disorder that is triggered by the ingestion of gluten in genetically susceptible individuals. The global prevalence of 1% to 2% represents only the tip of the iceberg. The diagnosis is confirmed by positive specific antibody, anti-transglutaminase or anti-endomysium, specific lesions of the small intestine and a response to strict gluten-free diet. The diagnosis is difficult and often delayed because the clinical variability is very large, ranging from digestive clinical presentation "classic" to "atypical" symptoms, often extra-intestinal, that are sometimes attributed to a concomitant disease or a complication...
November 4, 2016: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/27606438/vitamin-d-receptor-vdr-polymorphisms-in-pediatric-patients-presenting-with-hodgkin-s-lymphoma
#3
Sibel A Tekgündüz, Şule Yeşil, Ayşe C Ören, Hikmet G Tanyildiz, Mehmet O Çandir, Ceyhun Bozkurt, Gürses Şahin
Vitamin D receptor (VDR) polymorphisms are found more commonly in some tumor types than in healthy individuals, suggesting that some polymorphisms (Cdx2, Fok1, Bsm1, Apa1, Taq1) contribute to tumor development. There is no previous report on VDR polymorphism in Hodgkin's lymphoma (HL) patients. VDR polymorphism patterns in 95 pediatric HL cases with 100 healthy controls were compared. No statistically significant difference was found between the patient group and control group in terms of Cdx2, Fok1, Bsm1, Apa1, and Taq1 polymorphisms (P>0...
September 7, 2016: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/27588937/vitamin-d-mediated-hypercalcemia-mechanisms-diagnosis-and-treatment
#4
Peter J Tebben, Ravinder J Singh, Rajiv Kumar
Hypercalcemia occurs in up to 4% of the population in association with malignancy, primary hyperparathyroidism, ingestion of excessive calcium and/or vitamin D, ectopic production of 1,25-dihydroxyvitamin D [1,25(OH)2D], and impaired degradation of 1,25(OH)2D. The ingestion of excessive amounts of vitamin D3 (or vitamin D2) results in hypercalcemia and hypercalciuria due to the formation of supraphysiological amounts of 25-hydroxyvitamin D [25(OH)D] that bind to the vitamin D receptor, albeit with lower affinity than the active form of the vitamin, 1,25(OH)2D, and the formation of 5,6-trans 25(OH)D, which binds to the vitamin D receptor more tightly than 25(OH)D...
October 2016: Endocrine Reviews
https://www.readbyqxmd.com/read/27430408/vitamin-d-induces-autophagy-of-pancreatic-%C3%AE-cells-and-enhances-insulin-secretion
#5
Yubin Wang, Dawei He, Chengpei Ni, Huiying Zhou, Shuyan Wu, Zhimou Xue, Zhengyu Zhou
Epidemiological evidence indicates that vitamin D is involved in defense against diabetes; however, the precise underlying mechanism remains to be elucidated. In the present study, the effect of vitamin D on the pathogenesis of diabetes was investigated, with an emphasis on its direct effect on pancreatic β‑cells. A streptozotocin (STZ)‑induced type 1 diabetes mellitus (T1DM) mouse model and MIN6 mouse insulinoma β‑cells were subjected to vitamin D treatment. Histopathological analysis of pancreatic islets was performed to investigate insulitis, and reverse transcription-quantitative polymerase chain reaction and western blotting were used to determine the mRNA and protein expression levels of markers of autophagy [microtubule-associated protein 1A/1B‑light chain 3 (LC3) and Beclin 1] and regulation of apoptosis [B-cell lymphoma 2 (Bcl-2)]...
September 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27067393/the-effect-of-topical-diclofenac-3-and-calcitriol-3%C3%A2-%C3%AE-g-g-on-superficial-basal-cell-carcinoma-sbcc-and-nodular-basal-cell-carcinoma-nbcc-a-phase-ii-randomized-controlled-trial
#6
Tjinta Brinkhuizen, Kiki J A Frencken, Patty J Nelemans, Marlou L S Hoff, Nicole W J Kelleners-Smeets, Axel Zur Hausen, Michiel P J van der Horst, Dorit Rennspiess, Véronique J L Winnepenninckx, Maurice A M van Steensel, Klara Mosterd
BACKGROUND: Nonsteroidal anti-inflammatory drugs and vitamin-D derivatives can target signaling pathways activated in basal cell carcinoma (BCC). OBJECTIVE: We investigated the efficacy of topically applied diclofenac sodium 3% gel, calcitriol 3 μg/g ointment, and a combination of both in superficial BCC (sBCC) and nodular BCC. METHODS: Patients with a primary, histologically proven sBCC (n = 64) or nodular BCC (n = 64) were randomized to topical diclofenac, calcitriol, combination of both, or no topical treatment (control group)...
July 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27023968/normal-vitamin-d-level-impacts-lymphoma-outcomes
#7
(no author information available yet)
No abstract text is available yet for this article.
March 2010: Mayo Clinic Health Letter
https://www.readbyqxmd.com/read/26872557/season-of-diagnosis-is-associated-with-overall-survival-in-patients-with-diffuse-large-b-cell-lymphoma-but-not-with-hodgkin-s-lymphoma-a-population-based-swedish-lymphoma-register-study
#8
Elisabeth Székely, Ola Lindén, Stefan Peterson, Mats Jerkeman
OBJECTIVE AND METHODS: The aim of this study was to investigate the effect of season of diagnosis on the outcome of patients with diffuse large B-cell lymphoma (DLBCL) and Hodgkin lymphoma (HL). In this study, we included curatively treated DLBCL (n = 5875) and HL (n = 1693) patients, diagnosed between 2000 and 2011, based on data from the Swedish Lymphoma Register. RESULTS: Overall survival was significantly better for patients diagnosed with DLBCL during the summer months, but not for patients diagnosed with HL...
October 2016: European Journal of Haematology
https://www.readbyqxmd.com/read/26858923/hypocalcemia-in-malignancy-unexpected-but-common
#9
Bobby Diniotis, Evan Sternberg, Shrestha Shakuntala, Maguy Chiha, Pam Khosla
One of the most common metabolic abnormalities found in patients with malignancy is hypercalcemia. Hypocalcemia is a rare occurrence and is often found to be associated with renal failure and patients taking bisphosphonate therapy for bone metastasis in this patient population. Here, we present two different case reports with hypocalcemia. A 66-year-old female with a recent diagnosis of tonsillar diffuse B-cell lymphoma admitted with complaints of generalized weakness after one cycle of R-CHOP, found to have neutropenia, a low calcium level, high PTH, and low 25-hydroxy Vitamin D levels...
2015: Curēus
https://www.readbyqxmd.com/read/26837159/-vitamin-d-in-oncology-update-2015
#10
Uwe Gröber, Klaus Kisters, Irenäus A Adamietz
Vitamin D deficiency is associated with increased incidence of breast and colon cancer as well as with an unfavourable course of non-Hodgkin lymphoma. Vitamin D deficiency is common in cancer patients and is associated with poor cancer prognosis and disease progression. In breast cancer patients under polychemotherapy with anthracycline and taxane, a significant drop in 25(OH)D levels was observed. Osteo-malacia represents a new and previously unreported risk factor for the development of bisphosphonate-related osteonecrosis of the jaw...
December 2015: Medizinische Monatsschrift Für Pharmazeuten
https://www.readbyqxmd.com/read/26780396/combined-1-25-dihydroxy-vitamin-d-and-resveratrol-a-novel-therapeutic-approach-to-ameliorate-ischemia-reperfusion-induced-myocardial-injury
#11
Fatemeh Safari, Farideh Zarei, Shahnaz Shekarforoush, Asefeh Fekri, Mohsen Sharifi Klishadi, Seyedhossein Hekmatimoghaddam
The aim of this study was to assess the effect of combined 1,25-dihydroxyvitamin D (1,25 D) and resveratrol on cardiac arrhythmias, infarct size, and transcription of catalase, thioredoxin-1 and B-cell lymphoma 2 (Bcl-2), following myocardial ischemia-reperfusion (IR) in male rats. Ligation of coronary artery was performed in rats (n = 6 per group) without any treatment (IR group), pretreated with 0.1 μg/kg/day of 1,25 D (1,25 D + IR), 1 mg/kg/day of resveratrol (Res + IR) or a combination (1,25 D + Res + IR) for 14 days...
2015: International Journal for Vitamin and Nutrition Research. Journal International de Vitaminologie et de Nutrition
https://www.readbyqxmd.com/read/26770156/nothing-boring-about-boron
#12
REVIEW
Lara Pizzorno
The trace mineral boron is a micronutrient with diverse and vitally important roles in metabolism that render it necessary for plant, animal, and human health, and as recent research suggests, possibly for the evolution of life on Earth. As the current article shows, boron has been proven to be an important trace mineral because it (1) is essential for the growth and maintenance of bone; (2) greatly improves wound healing; (3) beneficially impacts the body's use of estrogen, testosterone, and vitamin D; (4) boosts magnesium absorption; (5) reduces levels of inflammatory biomarkers, such as high-sensitivity C-reactive protein (hs-CRP) and tumor necrosis factor α (TNF-α); (6) raises levels of antioxidant enzymes, such as superoxide dismutase (SOD), catalase, and glutathione peroxidase; (7) protects against pesticide-induced oxidative stress and heavy-metal toxicity; (8) improves the brains electrical activity, cognitive performance, and short-term memory for elders; (9) influences the formation and activity of key biomolecules, such as S-adenosyl methionine (SAM-e) and nicotinamide adenine dinucleotide (NAD(+)); (10) has demonstrated preventive and therapeutic effects in a number of cancers, such as prostate, cervical, and lung cancers, and multiple and non-Hodgkin's lymphoma; and (11) may help ameliorate the adverse effects of traditional chemotherapeutic agents...
August 2015: Integrative Medicine
https://www.readbyqxmd.com/read/26604936/prevention-and-treatment-of-bone-fragility-in-cancer-patient
#13
REVIEW
Silva Ottanelli
It is well known that fractures increase the risk of morbidity and mortality. The various mechanisms responsible for bone loss in cancer patients may have a different impact depending on the characteristics of the clinical case and correlates with the therapies used, or caused by the therapies used against cancer. Some hormonal treatments cause hypogonadism, event which contributes to the progressive loss of bone mass. This is detectable in patients with breast cancer receiving determines that estrogen-deprivation and in men with prostate cancer with therapies that determine androgen deprivation...
May 2015: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/26485664/novel-vitamin-d-analogues-cytotoxic-and-anti-proliferative-activity-against-a-diffuse-large-b-cell-lymphoma-cell-line-and-b-cells-from-healthy-donors
#14
Paweł Kozielewicz, Gillian Grafton, Andrzej Kutner, S John Curnow, John Gordon, Nicholas M Barnes
Calcitriol (1,25-dihydroxyvitamin D3, 1,25D3) and vitamin D side-chain modified analogs (VDAs) have gained considerable attention as potential drugs in the treatment of acute myeloid leukemia (AML), yet studies of the impact of 1,25D3 and VDAs upon other haematological malignancies are more limited. To address this gap in knowledge, we have examined the action of 1,25D3 and VDAs on a human cell line (DOHH2, K422) typifying diffuse large B-cell lymphoma (DLBCL) and also peripheral blood B-cells isolated from healthy donors...
October 17, 2015: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/26147207/chemotherapy-driven-dysbiosis-in-the-intestinal-microbiome
#15
E Montassier, T Gastinne, P Vangay, G A Al-Ghalith, S Bruley des Varannes, S Massart, P Moreau, G Potel, M F de La Cochetière, E Batard, D Knights
BACKGROUND: Chemotherapy is commonly used as myeloablative conditioning treatment to prepare patients for haematopoietic stem cell transplantation (HSCT). Chemotherapy leads to several side effects, with gastrointestinal (GI) mucositis being one of the most frequent. Current models of GI mucositis pathophysiology are generally silent on the role of the intestinal microbiome. AIM: To identify functional mechanisms by which the intestinal microbiome may play a key role in the pathophysiology of GI mucositis, we applied high-throughput DNA-sequencing analysis to identify microbes and microbial functions that are modulated following chemotherapy...
September 2015: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/26018151/promotion-of-endoplasmic-reticulum-associated-degradation-of-procathepsin-d-by-human-herpesvirus-8-encoded-viral-interleukin-6
#16
Daming Chen, John Nicholas
UNLABELLED: The interleukin-6 homologue (viral interleukin-6 [vIL-6]) of human herpesvirus 8 is implicated in viral pathogenesis due to its proproliferative, inflammatory, and angiogenic properties, effected through gp130 receptor signaling. In primary effusion lymphoma (PEL) cells, vIL-6 is expressed latently and is essential for normal cell growth and viability. This is mediated partly via suppression of proapoptotic cathepsin D (CatD) via cocomplexing of the endoplasmic reticulum (ER)-localized CatD precursor, pro-CatD (pCatD), and vIL-6 with the previously uncharacterized ER membrane protein vitamin K epoxide reductase complex subunit 1 variant 2 (VKORC1v2)...
August 2015: Journal of Virology
https://www.readbyqxmd.com/read/26005122/-american-academy-of-neurology-washington-18-25%C3%A2-april%C3%A2-2015
#17
I Sibon, B de Toffol, J-P Azulay, F Sellal, C Thomas-Antérion, J-M Léger, C Pierrot-Deseilligny
CEREBROVASCULAR DISEASES: The benefit of the thrombectomy using stents retrievers in the acute stroke phase is now demonstrated when there is a proximal occlusion of an intracranial artery, whatever its mechanism. The place of the anticoagulants in the management of cervical artery dissections remains uncertain, while the benefit of the blood pressure control in the secondary prevention of deep and lobar intracerebral hemorrhages is critical. The development of cardiac MRI, prolonged cardiac monitoring and transcranial doppler seems to improve the diagnosis of cardio-embolic sources of stroke...
June 2015: Revue Neurologique
https://www.readbyqxmd.com/read/25977096/pre-diagnostic-vitamin-d-concentrations-and-cancer-risks-in-older-individuals-an-analysis-of-cohorts-participating-in-the-chances-consortium
#18
José Manuel Ordóñez-Mena, Ben Schöttker, Veronika Fedirko, Mazda Jenab, Anja Olsen, Jytte Halkjær, Ellen Kampman, Lisette de Groot, Eugene Jansen, H Bas Bueno-de-Mesquita, Petra H Peeters, Galatios Siganos, Tom Wilsgaard, Laura Perna, Bernd Holleczek, Ulrika Pettersson-Kymmer, Philippos Orfanos, Antonia Trichopoulou, Paolo Boffetta, Hermann Brenner
The associations of circulating 25-hydroxyvitamin D [25(OH)D] concentrations with total and site-specific cancer incidence have been examined in several epidemiological studies with overall inconclusive findings. Very little is known about the association of vitamin D with cancer incidence in older populations. We assessed the association of pre-diagnostic serum 25(OH)D levels with incidence of all cancers combined and incidence of lung, colorectal, breast, prostate and lymphoid malignancies among older adults...
March 2016: European Journal of Epidemiology
https://www.readbyqxmd.com/read/25952779/a-review-of-rituximab-the-first-anti-cd20-monoclonal-antibody-used-in-the-treatment-of-b-non-hodgkin-s-lymphomas
#19
REVIEW
Pierre Feugier
Rituximab is a type I anti-CD20 monoclonal antibody, which stabilizes CD20 on lipid rafts, promoting antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity activities. It is the first targeted therapy used in B-cell malignancies and has revolutionized their treatment, without excess of toxicity. In combination with chemotherapy, it has significantly improved response rates and progression-free survival and, for some of them, overall survival of patients with diffuse large B-cell lymphoma, follicular lymphoma, marginal zone lymphoma, mantle cell lymphoma...
2015: Future Oncology
https://www.readbyqxmd.com/read/25871640/serum-25-hydroxyvitamin-d-levels-and-prognosis-in-hematological-malignancies-a-systematic-review-and-meta-analysis
#20
REVIEW
Wei Wang, Guangyun Li, Xiaoyan He, Jian Gao, Robin Wang, Yangang Wang, Wenjuan Zhao
BACKGROUND/AIMS: Serum 25-hydroxyvitamin D [25(OH)D] levels proved to be associated with prognosis of patients with colorectal cancer or breast cancer, but its prognostic role in hematological malignancies was still unclear. A systematic review and meta-analysis was performed to comprehensively evaluate the association between serum 25(OH)D levels and prognosis of patients with hematological malignancies. METHODS: We searched Pubmed, Embase, Web of Science, and Google Scholar for studies evaluating the association between serum 25(OH)D levels and prognosis of patients with hematological malignancies...
2015: Cellular Physiology and Biochemistry
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