keyword
https://read.qxmd.com/read/38534347/vitamin-d-in-cutaneous-t-cell-lymphoma
#1
REVIEW
August-Witte Feentved Ødum, Carsten Geisler
Cutaneous T-cell lymphoma (CTCL) is characterized by the proliferation of malignant T cells in inflamed skin lesions. Mycosis fungoides (MF)-the most common variant of CTCL-often presents with skin lesions around the abdomen and buttocks ("bathing suit" distribution), i.e., in skin areas devoid of sun-induced vitamin D. For decades, sunlight and vitamin D have been connected to CTCL. Thus, vitamin D induces apoptosis and inhibits the expression of cytokines in malignant T cells. Furthermore, CTCL patients often display vitamin D deficiency, whereas phototherapy induces vitamin D and has beneficial effects in CTCL, suggesting that light and vitamin D have beneficial/protective effects in CTCL...
March 13, 2024: Cells
https://read.qxmd.com/read/38354444/similar-geographic-distribution-of-mortality-from-multiple-sclerosis-hodgkin-lymphoma-and-inflammatory-bowel-disease-in-the-united-states
#2
JOURNAL ARTICLE
Amnon Sonnenberg
BACKGROUND: Previous epidemiologic studies have suggested a linkage between the occurrence of multiple sclerosis (MS), Hodgkin lymphoma (HL), Crohn's disease (CD), and ulcerative colitis (UC). It was hypothesized that the 4 diagnoses would be characterized by similar geographic distributions within the United States. AIMS: To compare the US geographic distributions of these 4 diagnoses in a cross-sectional study. METHODS: Using the US vital statistics, state-specific death rates and age-specific proportional mortality ratios (PMR) were calculated for each diagnosis...
February 10, 2024: Multiple Sclerosis and related Disorders
https://read.qxmd.com/read/38320825/hypercalcaemia-of-malignancy-a-case-of-vitamin-d-mediated-hypercalcaemia-in-lymphoma
#3
JOURNAL ARTICLE
Kanchi Mehta, Maham Awan, Shannon Devlin, Simerjot Kaur Jassal
Hypercalcaemia of malignancy (HCM) is a paraneoplastic syndrome that often portends a poor prognosis. We present an extremely rare (<1%) case of HCM due to extrarenal calcitriol (1,25-(OH)2 D) production in a patient with splenic marginal zone lymphoma. A man in his 80s presented with a 3-week history of fatigue, unsteadiness and abdominal pain, and new findings of anaemia, kidney injury and hypercalcaemia. Laboratory evaluation, bone marrow biopsy and positron emission tomography/computed tomography (PET/CT) confirmed the diagnosis of splenic marginal zone lymphoma which produced calcitriol (1,25-(OH)2 D3 ), causing the patient's hypercalcaemia...
February 6, 2024: BMJ Case Reports
https://read.qxmd.com/read/38177055/the-prognostic-significance-of-vitamin-d-deficiency-in-korean-patients-with-multiple-myeloma
#4
JOURNAL ARTICLE
Sejin Kim, Hyungwoo Cho, Miyoung Kim, Kyoungmin Lee, Shin Kim, Dok Hyun Yoon
BACKGROUND: Vitamin D deficiency is relatively common among patients with multiple myeloma. The prognostic significance of vitamin D deficiency in Asian patients with multiple myeloma remains unevaluated. This study aimed to assess the prognostic value of vitamin D levels in this Korean patient population. METHODS: From September 2017 to May 2020, 98 patients were enrolled in the study. Vitamin D deficiency was defined as 25-hydroxyvitamin D level of less than 10 ng/mL...
December 6, 2023: Clinical Lymphoma, Myeloma & Leukemia
https://read.qxmd.com/read/38125732/the-impact-of-circulating-25-hydroxyvitamin-d-and-vitamin-d-receptor-variation-on-leukemia-lymphoma-outcome-molecular-and-cytogenetic-study
#5
JOURNAL ARTICLE
Zahraa A Abdulrazaq, Mushtak T S Al-Ouqaili, Nabeel M Talib
Vitamin D (VD) potentially has a crucial function in the development of cancerous cells. This study aims to detect the role of vitamin D concentration and its receptor polymorphisms as possible prognostic biomarkers in patients with leukemia/lymphoma and further will attempt to detect the presence of the Philadelphia chromosome abnormality in chronic myeloid leukemia (CML). Seventy-five patients, in addition to 50 healthy individuals were included. Three single nucleotide polymorphisms of the vitamin D receptor (FokI, Tru91, and ApaI) were identified via Polymerase Chain Reaction- Fragment Length Polymorphism (PCR-RFLP)...
January 2024: Saudi Journal of Biological Sciences
https://read.qxmd.com/read/38108932/pediatric-primary-cutaneous-anaplastic-large-cell-lymphoma-with-associated-hypovitaminosis-d
#6
JOURNAL ARTICLE
Eleanor Tung-Hahn, Valerie Mogilevskiy, Ellie Black, Michael Morgan, Rebecca Tung
CD30+ lymphoproliferative diseases (LPDs) are relatively uncommon in the general population, especially in children. Distinguishing between the two main CD30+ LPDs, lymphomatoid papulosis and cutaneous anaplastic large-cell lymphoma is crucial, as the latter requires different treatment and systemic malignancy workup. We outline an uncommon presentation of a primary cutaneous anaplastic large-cell lymphoma (PC-ALCL) accompanied by hypovitaminosis D in a young Hispanic child and a holistic approach to treatment...
December 18, 2023: Archives of Dermatological Research
https://read.qxmd.com/read/38060095/integrative-approaches-in-the-treatment-of-patients-affected-by-lymphoma
#7
REVIEW
Ilana Levy Yurkovski, Francesca Andreazzoli, Eran Ben-Arye, Samuel Attias, Tamar Tadmor
PURPOSE OF REVIEW: Lymphoma is the most frequent hematological malignancy with wide disease spectrum of watchful waiting period, active treatment, survivorship, and palliative care. All these steps impose unmet needs in terms of prevention, symptom alleviation, or prognosis. Complementary and integrative medicine (CIM) is widely used by patients with lymphoma to cope with such issues. Here, we describe the different CIM modalities that may be effective and safe for the management of patients with lymphoma...
December 7, 2023: Current Oncology Reports
https://read.qxmd.com/read/38046558/covid-19-and-pre-morbid-lifestyle-related-risk-factors-a-review
#8
REVIEW
Ifeoma N Monye, Moyosore Taiwo Makinde, Tijani Idris Ahmad Oseni, Abiodun Bamidele Adelowo, Samba Nyirenda
Since its outbreak in December 2019 in China, COVID-19 has spread like wild fire to affect many communities of the world. The high infectivity and case fatality rates of the disease among the general population and the severely ill patients respectively drew the attention of the global community. Our review showed that socio-demographic and lifestyle-related risk factors and underlying comorbid diseases were directly and indirectly associated with increased susceptibility and severity of COVID-19. These factors included older age (⩾60 years), male gender, and ethnic minority groups (especially blacks), smoking, low serum level of vitamin D, unhealthy diet, physical inactivity (with poor exposure to sunlight), overweight/obesity, high blood pressure/hypertension, high blood cholesterol, cardiovascular diseases (like stroke and coronary heart disease), diabetes mellitus, chronic obstructive pulmonary disease, chronic kidney disease, chronic liver disease, and some cancers (like leukemia, lymphoma, or myeloma)...
2023: Health Services Insights
https://read.qxmd.com/read/37951853/25-hydroxy-vitamin-d-deficiency-is-an-inferior-predictor-of-peripheral-t-cell-lymphomas
#9
JOURNAL ARTICLE
Hao-Rui Shen, Jing Tang, Wen-Yi Li, Jin-Hua Liang, Yue Li, Jia-Zhu Wu, Li Wang, Jian-Yong Li, Rui Gao, Hua Yin, Wei Xu
The aim of the study was to explore the significance and prognostic value of 25-hydroxy vitamin D (25-(OH) D) deficiency in peripheral T-cell lymphomas (PTCLs). One hundred fifty-six patients of newly diagnosed PTCLs were enrolled in the study. Univariate and multivariate regression analyses were performed to determine independent risk factors for progression-free survival (PFS) and overall survival (OS). Receiver operating characteristic (ROC) curves were plotted, and corresponding areas under the curve (AUC) were calculated to estimate the accuracy of International Prognostic Index (IPI) plus 25-(OH) D deficiency and Prognostic Index for T-cell lymphoma (PIT) plus 25-(OH) D deficiency respectively in PTCL risk stratification...
November 11, 2023: Annals of Hematology
https://read.qxmd.com/read/37921981/effect-of-vitamin-d-on-cardiac-hypertrophy-in-d-galactose-induced-aging-model-through-cardiac-mitophagy
#10
JOURNAL ARTICLE
Siamak Shahidi, Khadijeh Ramezani-Aliakbari, Alireza Komaki, Iraj Salehi, Sayedpayam Hashemi, Sara Soleimani Asl, Parisa Habibi, Fatemeh Ramezani-Aliakbari
BACKGROUND: Cardiac apoptosis plays a key role in increased morbidity associated with aging-induced-cardiac disorder. Mitochondria play an important role in cardiac apoptosis, and dynamin-related protein 1 (Drp1), as a main mediator of mitochondrial fission, can trigger the mitophagy process to sustain the mitochondrial quality. The present study was done to determine the effect of vitamin D (VitD) treatment on cardiac hypertrophy through mitophagy regulation in aged animals induced by D-galactose (D-GAL)...
November 3, 2023: Molecular Biology Reports
https://read.qxmd.com/read/37920212/5-7-dimethoxycoumarin-ameliorates-vincristine-induced-neuropathic-pain-potential-role-of-5ht-3-receptors-and-monoamines
#11
JOURNAL ARTICLE
Muhammad Usman, Hurmat Malik, Ahmed Tokhi, Mehreen Arif, Zilli Huma, Khalid Rauf, Robert D E Sewell
Vincristine is the drug of choice for Hodgkin's lymphoma, acute lymphoblastic leukemia, and non-Hodgkin lymphoma. Despite its significant anticancer effects, it causes dose-dependent neuropathy, leading to compulsive dose reduction. The available drugs used for vincristine-induced neuropathic pain (VINP) have a range of safety, efficacy, and tolerability issues prompting a search for new therapies. 5,7-Dimethoxycoumarin (5,7-DMC) also known as citropten, is a natural coumarin found in the essential oils of citrus plants such as lime, lemons, and bergamots, and it possesses both antidepressant and anti-inflammatory effects...
2023: Frontiers in Pharmacology
https://read.qxmd.com/read/37876234/hypovitaminosis-d-in-haematological-malignancies-cause-or-consequence
#12
JOURNAL ARTICLE
Ouazzani Maha, Oubelkacem Nawal, Aboussaleh Youssef, Bikri Samir, Masrour Hajar, Alami Noufissa, El Lahrech Ibtissam, Rhandour Widad, Felk Rime, Saoudi Saloua, Meliani Kaoutar, Bouzayd Mounia, Bouchnafti Sanae, Oudrhiri Anas, Laghrib Latifa, Aberkane Laila, Hannini Rim, Chekkori Yassine, El Khammar Zineb, Berrady Rhizlane
Vitamin D is a pleiotropic hormone, widely controversial for its role in the development of chronic diseases and cancers, including haematological malignancies, and also for its impact on overall survival. Observational and interventional studies are being conducted on hypovitaminosis D and haematological malignancies and their subtypes in order to improve the therapeutic management of patients. We carried out a prospective observational study over three years on a population of 251 patients followed up for newly diagnosed haematological malignancies to investigate the impact of vitamin D deficiency on this category of patients...
October 24, 2023: Nutrition and Cancer
https://read.qxmd.com/read/37794442/metabolic-endocrine-disorders-in-survivors-of-childhood-onset-and-cranial-radiotherapy-treated-all-nhl-a-meta-analysis
#13
REVIEW
Dan Zhang, Min Gu
BACKGROUND: Cranial radiotherapy (CRT) is recommended to high-risk pediatric patients with acute lymphoblastic leukemia or aggressive non-Hodgkin's lymphoma (ALL/NHL). However, effects of CRT treatment on the development of metabolic/endocrine disorders remain unclear. This meta-analysis aimed to identify metabolic and endocrine disturbances in survivors of childhood-onset and CRT-treated ALL/NHL. METHODS: Different online databases were searched using restricted search fields...
October 4, 2023: Reproductive Biology and Endocrinology: RB&E
https://read.qxmd.com/read/37670819/malignant-hypercalcemia-revealing-a-diffuse-large-b-cell-lymphoma-in-a-patient-with-a-previous-diagnosis-of-chronic-myelomonocytic-leukemia-an-uncommon-hematological-coexistence
#14
Alpha Oumar Diallo, Amelie Marcou, Jérémie Lespinasse, Zaida Cordoba-Sosa, Emmanuel Andrès, Léa Docquier, Noel Lorenzo-Villalba
A 76-year-old patient previously admitted to the cardiology department for replacement of a right ventricular lead on a double-chamber pacemaker was admitted to the internal medicine department 15 days after for bronchopneumopathy. His past medical history was relevant for Type 2 diabetes mellitus, heart failure due to dilated hypokinetic heart disease, transcatheter aortic valve implantation (TAVI), and chronic myelomonocytic leukemia (CMML-0) diagnosed in 2021. Twenty-four hours after admission, the patient's general condition deteriorated abruptly, with the onset of drowsiness and psychomotor retardation...
September 2023: Clinical Case Reports
https://read.qxmd.com/read/37630689/vitamin-d-enhances-immune-effector-pathways-of-nk-cells-thus-providing-a-mechanistic-explanation-for-the-increased-effectiveness-of-therapeutic-monoclonal-antibodies
#15
JOURNAL ARTICLE
Konstantinos Christofyllakis, Frank Neumann, Moritz Bewarder, Lorenz Thurner, Dominic Kaddu-Mulindwa, Igor Age Kos, Vadim Lesan, Joerg Thomas Bittenbring
UNLABELLED: Patients with diffuse large cell lymphoma who have an adequate vitamin D supply derive significantly more benefit from immuno-chemotherapy with rituximab than patients with vitamin D deficiency; this is especially true for female patients. We have already been able to show that vitamin D increases the antibody-dependent cytotoxicity (ADCC) of NK cells in a sex-dependent manner, but it is unclear how vitamin D makes NK cells more efficient. METHODS: Healthy individuals with vitamin D deficiency were supplemented with vitamin D to sufficient levels...
August 8, 2023: Nutrients
https://read.qxmd.com/read/37572015/prognostic-significance-of-25-hydroxyvitamin-d-levels-in-patients-with-peripheral-t-cell-lymphoma
#16
JOURNAL ARTICLE
Young Gyu Park, Hyungwoo Cho, Shin Kim, Kyoungmin Lee, Jin-Sook Ryu, Eun Jin Chae, Kyung Won Kim, Chan-Sik Park, Heounjeong Go, Sang-Wook Lee, Yoon Sei Lee, Minsu Kwon, Chan Wook Kim, Dok Hyun Yoon
Vitamin D insufficiency has been linked to unfavourable outcomes in diverse malignancies. However, the prognostic significance of vitamin D levels in peripheral T-cell lymphoma (PTCL) remains unclear. In this study, we thus aimed to assess the prognostic relevance of 25-hydroxyvitamin D [25(OH)D] levels in patients newly diagnosed with PTCL. The analysis included 144 patients with PTCL treated from March 2015 to May 2020. The median 25(OH)D level was 12.2 (1.7-48.8) ng/mL, and 59 (41%) patients had vitamin D deficiency...
August 12, 2023: Leukemia & Lymphoma
https://read.qxmd.com/read/37251283/association-of-body-composition-and-handgrip-strength-with-interleukin-6-il-6-and-vitamin-d-level-in-cancer-patients
#17
JOURNAL ARTICLE
Noorwati Sutandyo, Della Manik Worowerdi Cintakaweni, Lyana Setiawan, Ririn Hariani, Nani Utami
INTRODUCTION: Cachexia is prevalent in cancer and is associated with poorer prognosis. We aimed to investigate the association of interleukin-6 (IL-6) and vitamin D levels with cachexia in cancer patients. We also assessed the relationship between body composition profile and cachexia, IL-6, and vitamin D levels. METHODS: A cross-sectional study was conducted at Dharmais National Cancer Hospital. The study included patients with newly diagnosed biopsy-proven nasopharyngeal cancer, lung cancer, breast cancer, cervical cancer, or non-Hodgkin lymphoma...
2023: International Journal of General Medicine
https://read.qxmd.com/read/37209191/association-of-serum-25-hydroxyvitamin-d-with-the-incidence-of-16-cancers-cancer-mortality-and-all-cause-mortality-among-individuals-with-metabolic-syndrome-a-prospective-cohort-study
#18
JOURNAL ARTICLE
E Wu, Jun-Ping Guo, Kai Wang, Hong-Quan Xu, Tian Xie, Lin Tao, Jun-Tao Ni
PURPOSE: The relationship between vitamin D levels and cancer incidence and mortality in individuals with metabolic syndrome (MetS) remains poorly explored. Herein, we aimed to determine the association between 25-hydroxyvitamin D [25(OH)D] concentrations and the risk of 16 cancer incidence types and cancer/all-cause mortality in patients with MetS. METHODS: We enrolled 97,621 participants with MetS at recruitment from the UK Biobank cohort. The exposure factor was baseline serum 25(OH)D concentrations...
May 20, 2023: European Journal of Nutrition
https://read.qxmd.com/read/37189455/vitamin-d-and-autoimmune-rheumatic-diseases
#19
REVIEW
Lambros Athanassiou, Ifigenia Kostoglou-Athanassiou, Michael Koutsilieris, Yehuda Shoenfeld
Vitamin D is a steroid hormone with potent immune-modulating properties. It has been shown to stimulate innate immunity and induce immune tolerance. Extensive research efforts have shown that vitamin D deficiency may be related to the development of autoimmune diseases. Vitamin D deficiency has been observed in patients with rheumatoid arthritis (RA) and has been shown to be inversely related to disease activity. Moreover, vitamin D deficiency may be implicated in the pathogenesis of the disease. Vitamin D deficiency has also been observed in patients with systemic lupus erythematosus (SLE)...
April 21, 2023: Biomolecules
https://read.qxmd.com/read/36913657/autoimmune-skin-conditions-psoriasis
#20
JOURNAL ARTICLE
Karl T Clebak, Leesha A Helm, Galen Foulke, Matthew Helm
Psoriasis is a chronic, inflammatory skin condition with significant effect on quality of life. It affects 3.2% of the United States population. Psoriasis is caused by an interaction between genetic and environmental triggers. Associated conditions include depression, increased cardiovascular risk, hypertension, hyperlipidemia, diabetes, nonalcoholic fatty liver disease, Crohn disease, ulcerative colitis, celiac disease, nonmelanoma skin cancers, and lymphoma. Several clinical variants exist, including chronic plaque, guttate, pustular, inverse, and erythrodermic psoriasis...
March 2023: FP Essentials
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