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Letrozole in fertility

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https://www.readbyqxmd.com/read/27821708/no-increased-risk-of-major-congenital-anomalies-or-adverse-pregnancy-or-neonatal-outcomes-following-letrozole-use-in-assisted-reproductive-technology
#1
T Tatsumi, S C Jwa, A Kuwahara, M Irahara, T Kubota, H Saito
STUDY QUESTION: Does letrozole use increase the risk of major congenital anomalies and adverse pregnancy and neonatal outcomes in fresh, single-embryo transfer? SUMMARY ANSWER: Letrozole significantly decreases the risk of miscarriage and does not increase the risk of major congenital anomalies or adverse pregnancy or neonatal outcomes compared with natural cycles in patients undergoing ART. WHAT IS KNOWN ALREADY: Letrozole is the most commonly used aromatase inhibitor for mild ovarian stimulation in ART...
November 7, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27695608/aromatase-inhibitors-for-endometriosis-associated-infertility-do-we-have-sufficient-evidence
#2
Hatem Abu Hashim
Orally active aromatase inhibitors (AIs) have gained attention for treatment of infertile women with endometriosis in whom aromatase p450 is aberrantly expressed. This review aimed to critically appraise and summarize the available evidence concerning the use of AIs for management of endometriosis-associated infertility. PubMed was searched to May 2015 with the following key words: endometriosis, infertility and aromatase. Priority was given for randomized controlled trials (RCTs) followed by other study designs...
October 2016: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/27685935/oocyte-cryopreservation-for-fertility-preservation-in-women-with-cancer
#3
Javier Domingo, Juan A Garcia-Velasco
PURPOSE OF REVIEW: It is necessary to clarify the fertility preservation-related points of concern that often frighten patients or physicians when it comes to deciding about oocyte cryopreservation for fertility preservation, which are often perceived as procedure limitations, are sometimes real and often theoretical and may make the prognosis worse. RECENT FINDINGS: Letrozole added to gonadotrophins for controlled ovarian stimulation is safe when applied to hormone-sensitive cancer patients as it avoids associated high estradiol levels...
December 2016: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/27511809/the-management-of-anovulatory-infertility-in-women-with-polycystic-ovary-syndrome-an-analysis-of-the-evidence-to-support-the-development-of-global-who-guidance
#4
REVIEW
Adam H Balen, Lara C Morley, Marie Misso, Stephen Franks, Richard S Legro, Chandrika N Wijeyaratne, Elisabet Stener-Victorin, Bart C J M Fauser, Robert J Norman, Helena Teede
BACKGROUND: Here we describe the consensus guideline methodology, summarise the evidence-based recommendations we provided to the World Health Organisation (WHO) for their consideration in the development of global guidance and present a narrative review on the management of anovulatory infertility in women with polycystic ovary syndrome (PCOS). OBJECTIVE AND RATIONALE: The aim of this paper was to present an evidence base for the management of anovulatory PCOS...
November 2016: Human Reproduction Update
https://www.readbyqxmd.com/read/27488701/a-comparison-among-different-methods-of-letrozole-combined-with-gonadotropin-in-an-antagonist-protocol-and-high-dose-gonadotropin-ovarian-stimulation-antagonist-protocol-in-poor-ovarian-responders-undergoing-in-vitro-fertilization
#5
Rui Yang, Hongzhen Li, Rong Li, Ping Liu, Jie Qiao
PURPOSE: This study aimed at comparing the effects of different methods of letrozole combined with gonadotropin (Gn) and high-dose Gn ovarian stimulation in antagonist protocol. METHODS: Retrospectively reviewed 220 poor responders from August 2012 to July 2014 at Peking University Third Hospital Reproductive Medical Center. Patients were divided into Group 1 (LZ 5 mg for 5 days sequentially overlapping with Gn cycles; n = 60), group 2 (LZ 7.5 mg for 3 days sequentially with Gn cycles; n = 60), and group 3 (high-dose Gn cycles; n = 100)...
November 2016: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/27428850/fertility-preservation-in-women-with-borderline-ovarian-tumours
#6
REVIEW
Giorgia Mangili, Edgardo Somigliana, Veronica Giorgione, Fabio Martinelli, Francesca Filippi, Maria Cristina Petrella, Massimo Candiani, Fedro Peccatori
Borderline ovarian tumours (BOT) may occur in young women and have an excellent survival rate. Therefore, there is the obligation to put emphasis on fertility preservation in affected women. On the other hand, it has also been underlined that the disease should be managed with caution because these tumours can relapse and, albeit rare, malignant transformation can also occur. Unfortunately, evidence on fertility preservation in women with BOT is scanty. In this opinion paper, we tried to draw some clinical indications based on the few available studies on the clinical management of BOT and their possible relation with controlled ovarian hyper-stimulation (COH)...
September 2016: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/27402910/fertility-related-quality-of-life-from-two-rct-cohorts-with-infertility-unexplained-infertility-and-polycystic-ovary-syndrome
#7
Nanette Santoro, Esther Eisenberg, J C Trussell, LaTasha B Craig, Clarisa Gracia, Hao Huang, Ruben Alvero, Peter Casson, Gregory Christman, Christos Coutifaris, Michael Diamond, Susan Jin, Richard S Legro, Randal D Robinson, William D Schlaff, Heping Zhang
STUDY QUESTION: Does fertility-related quality of life (FertiQOL) differ by infertility diagnosis between women with polycystic ovary syndrome (PCOS) and their partners, compared with couples with unexplained infertility (UI)? SUMMARY ANSWER: Women with PCOS report lower QOL than those with UI, whereas males with UI report lower QOL than males with PCOS partners. WHAT IS KNOWN ALREADY: The fertility-specific QOL survey, FertiQOL, has been used to examine fertility-related QOL in a number of worldwide cohorts...
October 2016: Human Reproduction
https://www.readbyqxmd.com/read/27236602/a-randomized-single-blind-prospective-trial-comparing-three-different-gonadotropin-doses-with-or-without-addition-of-letrozole-during-ovulation-stimulation-in-patients-with-poor-ovarian-response
#8
Ercan Bastu, Faruk Buyru, Mehmet Ozsurmeli, Irem Demiral, Murat Dogan, John Yeh
OBJECTIVE: The aim of this randomized controlled trial (RCT) was to investigate whether IVF outcomes would differ between patients with POR who received three different gonadotropin doses with or without the addition of letrozole during ovulation stimulation. STUDY DESIGN: Only those who fulfilled two of the three Bologna criteria were included to the study. 95 patients met the inclusion criteria and agreed to participate in the study. In the first group, 31 patients were treated with 450IU gonadotropins...
August 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27172763/twin-delivery-after-ivf-et-with-variable-dose-letrozole-fsh-protocol-of-lower-estradiol-in-a-patient-previously-treated-for-breast-cancer-a-case-report
#9
Chang-Jun Zhang, Ying Zhang, Guang-Zhu Hu, Honglu Diao
OBJECTIVE: To present a case of twin pregnancy obtained by in vitro fertilization and embryo transfer (IVF-ET) with variable dose letrozole-FSH protocol of lower peak estradiol level, after treatment of carcinoma of the breast. MATERIALS AND METHODS: A 34-year-old patient diagnosed with mucinous breast carcinoma undergoing assisted fertilization treatment after breast cancer operation and treatment including controlled ovarian stimulation (COS), oocyte retrieval, IVF, and embryo culture and transfer...
2016: European Journal of Gynaecological Oncology
https://www.readbyqxmd.com/read/27077394/the-benefits-of-other-treatments-than-in-vitro-fertilization-to-aid-conception-in-minimal-and-mild-endometriosis
#10
Annie S Leung, Michael H Dahan
The treatment of minimal or mild endometriosis prior to non-in-vitro fertilization (IVF) assisted reproduction to improve pregnancy outcomes is controversial. Ovulation suppression may be offered to women who do not wish to conceive to suppress advancement of the disease. There is little evidence to suggest improvements in fertility associated ovarian suppression prior to non-IVF infertility treatments. The use of intrauterine insemination without ovulation induction offers little benefit, with low pregnancy rates in most studies...
December 2016: Minerva Ginecologica
https://www.readbyqxmd.com/read/26949110/predictors-of-pregnancy-and-live-birth-in-couples-with-unexplained-infertility-after-ovarian-stimulation-intrauterine-insemination
#11
Karl R Hansen, Amy Linnea W He, Aaron K Styer, Robert A Wild, Samantha Butts, Lawrence Engmann, Michael P Diamond, Richard S Legro, Christos Coutifaris, Ruben Alvero, Randal D Robinson, Peter Casson, Gregory M Christman, Hao Huang, Nanette Santoro, Esther Eisenberg, Heping Zhang
OBJECTIVE: To identify baseline characteristics of couples that are likely to predict conception, clinical pregnancy, and live birth after up to four cycles of ovarian stimulation with IUI in couples with unexplained infertility. DESIGN: Secondary analyses of data from a prospective, randomized, multicenter clinical trial investigating pregnancy, live birth, and multiple pregnancy rates after ovarian stimulation-IUI with clomiphene citrate, letrozole, or gonadotropins...
June 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/26931252/comparison-of-success-of-clomiphene-citrate-and-letrozole-in-ovulation-induction
#12
COMPARATIVE STUDY
J Saha, S Akhter, I Prasad, S Siddiq
The study was carried out to evaluate which drug is better in ovulation induction between clomiphene citrate and letrozole. The study was carried out in the infertility unit of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka and Centre for Assisted Reproduction (CARE) at Bangladesh Institute of Research and Rehabilitation in Diabetes Endocrine and Metabolic Disorders (BIRDEM), Dhaka from January 2007 to December 2007. One hundred and sixty five cases were taken for the study. It was a prospective interventional comparative study of clomiphene citrate and letrozole in infertile cases...
January 2016: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/26924899/oral-drugs-for-unexplained-infertility
#13
Gautam N Allahbadia
Of the infertile couples unable to conceive without any identifiable cause, 30 % are defined as having unexplained infertility. Management depends on duration of infertility and age of female partner. The treatment of unexplained infertility is empirical, and many different regimens have been used. Among these are expectant management, ovarian stimulation with clomiphene citrate, gonadotropins and aromatase inhibitors, fallopian tube sperm perfusion, tubal flushing, intrauterine insemination, gamete intrafallopian transfer, and IVF...
February 2016: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/26775457/predictive-value-of-elevated-lh-fsh-ratio-for-ovulation-induction-in-patients-with-polycystic-ovary-syndrome
#14
Irene Woo, Kyle Tobler, Ayatallah Khafagy, Mindy S Christianson, Melissa Yates, Jairo Garcia
OBJECTIVE: To assess the value of an elevated luteinizing hormone (LH)-to-follicle-stimulating hormone (FSH) ratio in predicting development of a dominant follicle when ovulation induction is implemented with clomiphene citrate (CC) or letrozole in women with polycystic ovary syndrome (PCOS). STUDY DESIGN: Retrospective review of 312 monitored cycles between 2007 and 2012. All patients met the diagnostic criteria set by the 2006 Androgen Excess-PCOS Society and had baseline LH and FSH levels drawn...
November 2015: Journal of Reproductive Medicine
https://www.readbyqxmd.com/read/26751194/long-term-safety-of-letrozole-and-gonadotropin-stimulation-for-fertility-preservation-in-women-with-breast-cancer
#15
Jayeon Kim, Volkan Turan, Kutluk Oktay
This prospective non-randomized controlled study showed no increased recurrence risk in breast cancer patients who pursued fertility preservation via controlled ovarian stimulation with letrozole during the 5 years after diagnosis.
April 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/26644850/comparison-of-the-effectiveness-of-clomiphene-citrate-versus-letrozole-in-mild-ivf-in-poor-prognosis-subfertile-women-with-failed-ivf-cycles
#16
Mesut Oktem, Ismail Guler, Mehmet Erdem, Ahmet Erdem, Nuray Bozkurt, Onur Karabacak
BACKGROUND: Our objective was to evaluate the effectiveness of clomiphene citrate (CC) vs. letrozole (L) plus human menopausal gonadotropin (hMG) in gonadotropin releasing hormone (GnRH) antagonist protocol in poor prognosis women with previous failed ovarian stimulation undergoing intracytoplasmic sperm injection (ICSI). MATERIALS AND METHODS: This retrospective cohort study included cycles with CC and L plus hMG/GnRH antagonist protocols of 32 poor responders who had failed to have ideal follicles to be retrieved during oocyte pick-up (OPU) or embryo transfer (ET) at least for 2 previous in vitro fertilization (IVF) cycles with microdose flare protocol or GnRH antagonist protocol from January 2006 to December 2009...
October 2015: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/26642102/american-association-of-clinical-endocrinologists-american-college-of-endocrinology-and-androgen-excess-and-pcos-society-disease-state-clinical-review-guide-to-the-best-practices-in-the-evaluation-and-treatment-of-polycystic-ovary-syndrome-part-2
#17
REVIEW
Neil F Goodman, Rhoda H Cobin, Walter Futterweit, Jennifer S Glueck, Richard S Legro, Enrico Carmina
Polycystic ovary syndrome (PCOS) is recognized as the most common endocrine disorder of reproductive-aged women around the world. This document, produced by the collaboration of the American Association of Clinical Endocrinologists and the Androgen Excess Society aims to highlight the most important clinical issues confronting physicians and their patients with PCOS. It is a summary of current best practices in 2014. Insulin resistance is believed to play an intrinsic role in the pathogenesis of PCOS. The mechanism by which insulin resistance or insulin give rise to oligomenorrhea and hyperandrogenemia, however, is unclear...
December 2015: Endocrine Practice
https://www.readbyqxmd.com/read/26583517/in-vitro-fertilisation-for-unexplained-subfertility
#18
REVIEW
Zabeena Pandian, Ahmed Gibreel, Siladitya Bhattacharya
BACKGROUND: One-third of subfertile couples have no identifiable cause for their inability to conceive. In vitro fertilisation (IVF) is a widely accepted treatment for this condition; however, this treatment is invasive and expensive and is associated with risks. OBJECTIVES: To evaluate the effectiveness and safety of IVF compared with expectant management, unstimulated intrauterine insemination (IUI) or intrauterine insemination along with ovarian stimulation with gonadotropins (IUI + gonadotropins) or clomiphene (IUI + CC) or letrozole (IUI + letrozole) in improving pregnancy outcomes...
2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26507278/live-birth-following-early-follicular-phase-oocyte-collection-and-vitrified-warmed-embryo-transfer-8-days-later
#19
Safak Hatırnaz, Ebru Hatırnaz, Baris Ata
A 30-year-old woman with premature ovarian insufficiency had two follicles measuring 17 mm and 14 mm on day 3 of her menstrual cycle. Serum oestradiol concentration was 210 pg/ml. Recombinant human chorionic gonadotrophin was given and 5 mg/day letrozole started orally. One metaphase II oocyte was collected 36 h later. A 4-cell embryo was vitrified on the second day after fertilization. Letrozole was stopped on cycle day 8 due to absence of any other visible antral follicles. Oestradiol valerate 6 mg/day was started and the endometrium was 9...
December 2015: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/26487376/controlled-ovarian-hyperstimulation-with-sequential-letrozole-co-treatment-in-normo-high-responders
#20
Tolga Ecemis, Yasemin Tasci, Gamze Sinem Caglar
OBJECTIVE: To investigate the effect of co-administration of letrozole in an ovarian stimulation protocol using recombinant FSH and GnRH antagonists for ICSI in normo/high responders. METHODS: Computerized data of 320 antagonist ICSI/ET cycles with or without letrozole were retrospectively analyzed. In 105 cases, letrozole (5 mg/day) was started at the second day of the cycle continued for 5 days. At the second day of letrozole, gonadotropins were added. The remaining 215 cases were stimulated with recombinant FSH only...
2016: Gynecological Endocrinology
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