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Perimenopausal syndrome

Cindy Meun, Oscar H Franco, Klodian Dhana, Loes Jaspers, Taulant Muka, Yvonne Louwers, M Arfan Ikram, Bart C J M Fauser, Maryam Kavousi, Joop S E Laven
Context: Polycystic ovary syndrome (PCOS) is closely linked to hyperandrogenism. In PCOS, hyperandrogenism has been associated with metabolic disturbances which increase the risk for cardiovascular disease (CVD). Objective: To assess the association of high serum androgen levels, as a postmenopausal remnant of PCOS, with the prevalence of atherosclerosis and incidence of CVD in postmenopausal women. Design: The Rotterdam Study, a prospective population-based cohort study...
February 1, 2018: Journal of Clinical Endocrinology and Metabolism
Pin-Li Chen, Wen-Jun Wang, Yan-Qiu Rao, Jun Li, Ming-Jun Cheng
As the resident macrophages of the brain's innate immune system, microglial cells are key modulators in the neurodegenerative disease Alzheimer's disease (AD). In particular, the activation and accumulation of microglial cells around amyloid plaques is considered to result in chronic neuroinflammation. Although the pathologic mechanism remains to be fully elucidated, inflammation has been shown to be critical in the pathogenesis of AD. The Gengnianchun (GNC) formula has long been used to treat perimenopausal syndrome clinically, and is particularly effective in improving learning ability and memory...
January 31, 2018: Molecular Medicine Reports
Kun Ma, Yan-Xia Chen, Mei-Ling Dong
Perimenopausal syndrome refers to a series of physical and mental symptoms, caused by the fluctuation of the sex hormones in the menopause, which is one of the common diseases in gynecology. The incidence of sleep disorders in perimenopausal women is increasing significantly. Both Chinese medicine and Western medicine are trying to exploring its pathologic mechanism to find the safe and effective methods of treatment. Menopausal sleeping disorder is the same as the perimenopause syndrome and insomnia category in traditional Chinese medicine...
December 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Zhiliang Cao, Jian Tang, Yuting Xue, Qiong Wang, Saiqun Li, Youjun Zhou, Wei Zhang
OBJECTIVE: To compare the effect and differences sex the influence of hormone levels of perimenopau-sal syndrome patients between manual acupuncture and electroacupuncture (EA). METHODS: A total of 50 cases with perimenopausal syndrome were randomly assigned into an manual acupuncture group (27 cases) and an EA group (23 cases), and 1 case dropped in the EA group. The acupoints in the two groups were Guanyuan (CV 4), Zigong (EX-CA 1), Tianshu (ST 25), and Sanyinjiao (SP 6)...
March 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
Yuan Zhao, Hong-Xia Zheng, Ying Xu, Na Lin
Phytoestrogens are plant-derived compounds, which have a similarity in structure with human endogenous estrogen 17-β-estradiol. Structural likeness enables phytoestrogens to interact with estrogen receptors, not simply mimicking the effects of human steroidal estrogen but also exhibiting similar and divergent actions. The global literature relating to phytoestrogen in recent years was systematically summarized in this paper. Chemical compositions of phytoestrogens were mainly flavonoids, coumarins, lignans, terpenoids, steroids, etc...
September 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Faizan Mazhar, Jabeen Sultana, Shahzad Akram
Misoprostol is a synthetic analog of prostaglandin-E1 and it is most widely used drug for the medical management of incomplete abortion. Acute coronary syndrome (ACS) rarely occurs in perimenopausal women, in addition, the presentation is atypical, so the disease is not always recognized. We describe a case of 39-year-old woman with no major underlying cardiovascular risk factors, who developed an episode of ACS following the administration of two doses of misoprostol. After the discontinuation of misoprostol treatment, there was a complete resolution of patient's symptoms...
November 21, 2017: Current Drug Safety
Lihong Gao, Xiaojie Wu, Xia Liu, Qinglan Pu, Meiguang Zhang, Yingru Cai, Lizhong Wang, Wei Zhao, Jiming Chen
This study was aimed to investigate the attitudes and knowledge of medical personnel on hormone replacement therapy (HRT) in treating perimenopausal syndrome. A total of 2580 self-administered questionnaire forms were sent to medical care professionals and the responses collected were anonymous. The questionnaire included information on levels of awareness, benefits, and potential risks of HRT. A total of 2158 questionnaire forms were filled and used for statistical analysis; 61.4% of gynecologists believed that it was necessary to conduct HRT in suitable patients, 89...
November 22, 2017: Gynecological Endocrinology
Todd D Rozen
OBJECTIVE: To describe a new subtype of chronic daily headache in women of a specific age group. METHODS: Case series. RESULTS: Eight patients were included in the presented case series. The average age of onset of this distinct headache condition is 57 years. All patients were either perimenopausal or in menopause when the headaches started. The syndrome is marked by bilateral head pain that starts daily from onset and is typically at its most severe intensity the first thing in the morning before arising or when in the supine position...
September 25, 2017: Journal of Women's Health
Ying Wang, Weichao Shan, Qing Li, Na Yang, Weiying Shan
BACKGROUND: Improvement of the quality of life in perimenopausal women has recently become an important global health issue. Extensive research reports provide evidence of Tai Chi for the quality of life, but no systematic review has individually investigated Tai Chi as a main intervention on the quality of life in perimenopausal women. OBJECTIVE: To assess clinical evidence of Tai Chi for the quality of life in perimenopausal women. METHODS: Studies related to the effect of Tai Chi on the quality of life in perimenopausal women in the databases of China and abroad were searched...
August 2017: Worldviews on Evidence-based Nursing
Travis Peck, Leslie Olsakovsky, Shruti Aggarwal
Dry eye disease (DED) is a multifactorial ocular surface disease that causes symptoms of ocular pain, discomfort, and decreased visual acuity. It significantly affects quality of life of patients. It is more prevalent in the females and is being specifically in the menopausal and postmenopausal age group. This is believed to be due to the changes in balance of sex hormones. Sex hormones - estrogens and androgens - influence production of all components of the tear film including aqueous layer, lipid, and mucin...
April 2017: Journal of Mid-life Health
Rashmi Kushwaha, Ashutosh Kumar, Kusum Lata Mishra, Pushp Lata Sankhwar, Renu Singh
INTRODUCTION: Menorrhagia is a common gynaecological problem and its cause remains unexplained in a significant proportion of females. AIM: The present study was done to diagnose a wide range of haemostatic disorders which can give rise to menorrhagia in women of adolescent, postadolescent and perimenopausal age group. MATERIALS AND METHODS: A total of 1100 women presenting to gynaecological emergency with complaints of menorrhagia underwent comprehensive evaluation...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
Yibing Lan, Yizhou Huang, Yang Song, Linjuan Ma, Peiqiong Chen, Qian Ying, Wei Li, Yuqun Cai, Jianhong Zhou
OBJECTIVE: The aim of the study was to specify the prevalence and severity of menopausal symptoms, and to investigate associated factors in Chinese middle-aged women. METHODS: A cross-sectional, community-based study was carried out involving 1,054 participants aged 40 to 60 years in Gongshu District, Hangzhou, Zhejiang, PR China. The presence and severity of symptoms were evaluated by having the participants complete a modified Kupperman Menopausal Index questionnaire...
October 2017: Menopause: the Journal of the North American Menopause Society
T V Kirichenko, V A Myasoedova, V A Orekhova, A L Ravani, N A Nikitina, A V Grechko, I A Sobenin, A N Orekhov
The present study evaluated the risks and benefits of phytoestrogen treatment in healthy perimenopausal women in relation to the dynamics of climacteric syndrome and progression of atherosclerosis. Study participants were treated with placebo or phytoestrogen-rich natural preparation Karinat based on grape (Vitis vinifera) seeds, green tea (Camellia sinensis) leaves, hop (Hunulus lupulus) cone powder and garlic (Allium sativum) powder. The dynamics of climacteric syndrome was evaluated by Kupperman Index and Utian Quality of Life Scale...
August 2017: Phytotherapy Research: PTR
Feras Husain Abuzeyad, Eltigani Seedahmed Ibnaouf, Mudhaffar Al Farras
Nonatherosclerotic spontaneous coronary artery dissection (NA-SCAD) is an uncommon cause of myocardial infarction. It most commonly affects females in the perimenopausal age. NA-SCAD has been associated with many predisposing factors including pregnancy and hormonal therapy for both contraception and ovulation induction. The presented case is a previously healthy 41-year-old woman diagnosed with inferior ST-elevation myocardial infarction due to right descending coronary artery dissection associated with recent use of clomiphene monotherapy for ovulation induction (a previously fertile woman), which was not previously reported...
2017: Case Reports in Emergency Medicine
T V Orlyk, N V Grygorieva, V V Povoroznyuk
We have analyzed the vertebral pain syndrome (VPS) rate in 2 844 women aged 40-89 years, divided into groups according to the period of life (reproductive, perimenopausal and postmenopausal (PMP)) and evaluated the relationship between VPS frequency and indices of bone mineral density (BMD). It was found that the frequency of VPS during different physiological periods of woman life ranges from 84,1 to 94,4 %, with significant increase when the PMP period is more than 20 years compared with women in reproductive and early postmenopausal periods...
2017: Advances in Gerontology, Uspekhi Gerontologii
Kerstin Weidner, Ilona Croy, Timo Siepmann, Elmar Brähler, Manfred Beutel, Antje Bittner
OBJECTIVE: The menopausal syndrome is described as a series of various physical and nonphysical symptoms attributed to perimenopausal changes in hormone levels. However, evidence is biased by focusing research on the target group of middle aged women only. To overcome this bias, we examined the occurrence of menopausal symptoms during the entire life span in both women and men. METHODS: Therefore, we studied the occurrence of menopausal symptoms with the widely used Menopause Rating Scale (MRS) across the entire life span in both women and men...
March 29, 2017: Journal of Psychosomatic Obstetrics and Gynaecology
Jee Sun Jeong, Hyuk Sang Kwon
The prevalence of hypercholesterolemia in Koreans 30 years old and over was 19.5% in 2015 according to the Korean Nutrition and Health Examination Survey, which means that one-fifth of adults had hypercholesterolemia. The prevalence of hypertriglyceridemia in adults 30 years of age and older was 16.8% in 2015, and men had a 2-fold higher prevalence of hypertriglyceridemia than women (23.9% vs. 10.4%). The awareness of hypercholesterolemia in Koreans was higher in women than among men (62.4% vs. 51.4%). It increased with age; the level of awareness in participants 30 to 49 years of age (32...
March 2017: Endocrinology and Metabolism
Agnieszka Olszanecka, Aneta Dragan, Kalina Kawecka-Jaszcz, Danuta Fedak, Danuta Czarnecka
PURPOSE: During the transition from premenopause to postmenopause, many women experience weight gain and central fat deposition; therefore, we hypothesized that circulating growth factors can play a role in the pathogenesis of hypertension, metabolic syndrome, and subclinical organ damage in perimenopausal women. BASIC PROCEDURES: The study included 192 women aged 40 to 60years; 152 had newly diagnosed essential hypertension that had never been treated, and 40 were normotensive age-matched controls...
April 2017: Metabolism: Clinical and Experimental
S Xi, L Mao, X Chen, W Bai
OBJECTIVE: This study aimed to evaluate the effect of health education combining diet and exercise supervision on menopausal symptoms and diet/exercise habits. METHODS: The randomized controlled study enrolled 60 patients with perimenopausal syndrome (Kupperman Menopause Index (KMI) score ≥15). The participants were randomized into either an intervention group (n = 30) or a control group (n = 30). Women were interviewed with questionnaires about perimenopausal symptoms, diet pattern and exercise habit...
April 2017: Climacteric: the Journal of the International Menopause Society
Jorge Hernâni-Eusébio, Elisabete Barbosa
INTRODUCTION: Lynch syndrome is the most common form of hereditary colorectal cancer, being also responsible for endometrial and other types of cancers. It is associated with germline mutations in DNA mismatch repair genes and microsatellite instability. MLH1 and MSH2 mutations have a "classical" Lynch syndrome phenotype, with MSH2 having a higher association with extracolonic cancer. MSH6 and PMS2 mutations have an atypical phenotype. Clinical expression is heterogeneous, with correlation between mismatch repair mutated gene and phenotypic patterns...
October 2016: Acta Médica Portuguesa
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