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Perimenopausal syndrome

Ai-Jun Sun, Ya-Ping Wang, Bei Gu, Ting-Ping Zheng, Shou-Qing Lin, Wen-Pei Bai, Yang Wei, Shao-Fen Zhang, Ying Zhang
OBJECTIVE: To evaluate the efficacy and safety of Heyan Kuntai Capsule (, HYKT) and hormone therapy (HT) on perimenopausal syndromes (PMSs). METHODS: From 2005 to 2008, 390 women with PMSs were recruited from 4 clinic centers. The inclusion criteria included ages 40 to 60 years, estradiol (E2) below 30 ng/L, and follicle stimulating hormone (FSH) above 40 IU/L, etc. The patients were randomly assigned to HYKT group or HT group by random number table method, administrated HYKT or conjugated estrogen with/without medroxyprogesterone acetate tablets for 12 months...
September 20, 2016: Chinese Journal of Integrative Medicine
Patsama Vichinsartvichai, Siriwan Sirirat
INTRODUCTION: Prevalence of metabolic syndrome increases drastically during menopausal transition. Chronic inflammation is proposed as the basic pathophysiology of metabolic syndrome (MetS). AIM OF THE STUDY: To compare mean white blood cell count between perimenopausal and postmenopausal women with and without MetS and find the prevalence of MetS in this patient group. MATERIAL AND METHODS: A total of 140 healthy perimenopausal and postmenopausal women were interviewed and underwent anthropometric measurements, biochemical investigations for MetS and hematologic parameters...
June 2016: Przeglad Menopauzalny, Menopause Review
Wenjuan Wang, Guangxia Cui, Biao Jin, Ke Wang, Xing Chen, Yu Sun, Lihua Qin, Wenpei Bai
Perimenopausal syndromes begin as ovarian function ceases and the most common symptoms are hot flushes. Data indicate that the projections of serotonin to hypothalamus may be involved in the mechanism of hot flushes. Therefore, the aim of this study is to investigate the potential role of the serotonin dorsal raphe-preoptic hypothalamus pathway for hot flushes in an animal model of menopause. We determined the changes in serotonin expression in the dorsal raphe (DR) and preoptic anterior hypothalamus (POAH) in ovariectomized rats...
August 22, 2016: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
Audrey Binette, Kerry Howatt, Ashley Waddington, Robert L Reid
Despite the introduction of promising products into the contraceptive market, the rate of unintended pregnancies remains high. Women with underlying medical conditions should have access to safe and effective contraceptive methods for various reasons, including the potential deleterious effect of the disease on the pregnancy or the effect of the pregnancy on the disease process. Healthcare providers are often confronted with cases in which contraception counseling is problematic due to controversial evidence and persistent myths...
August 22, 2016: Journal of Women's Health
W Xue, A J Sun, T P Zheng, J F Jiang, Y P Wang, Y Zhang, F L Chen, Y Deng, Y F Wang
OBJECTIVE: To explore the effects of five different therapy in women at early stage of menopause on menopausal symptoms, quality of Life and cardiovascular risk factors. METHODS: A total of 140 women at early stage of menopause were randomly divided into five groups. Thirty women took Conjugated estrogen and medroxyprogesterone acetate(CEE+ MPA) sequential therapy, 27 women took estradiol valerate and medroxyprogesterone acetate(E2V+ MPA) sequential therapy, 26 women took estradiol valerate and Progesterone Soft Capsules(E2V+ P) sequential therapy, 30 women took Kuntai capsule, and 27 took Cohosh extract...
August 2, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Rui-Xia Li, Min Ma, Xi-Rong Xiao, Yan Xu, Xiu-Ying Chen, Bin Li
Limited information was focused on perimenopausal syndrome and mood disorders (depression and anxiety) in a specific population: perimenopausal women. We aimed to investigate the prevalence and severity of perimenopausal syndrome and mood disorders, and to analyze their relationships and risk factors in perimenopausal women in Shanghai, China.A cross-sectional study was performed on 1062 women aged 40 to 60 years from 3 communities. The general conditions questionnaire, Kupperman index, self-rating depression scale, and self-rating anxiety scale were used...
August 2016: Medicine (Baltimore)
Matthew J Gurka, Abhishek Vishnu, Richard J Santen, Mark D DeBoer
BACKGROUND: After menopause, women exhibit a higher prevalence of the metabolic syndrome (MetS) and higher risk of cardiovascular disease. However, the timing of changes in MetS severity over the menopausal transition and whether these changes differ by racial/ethnic group remain unclear. METHODS AND RESULTS: We assessed data from 1470 women from the Atherosclerosis Risk in Communities cohort who experienced transition in menopausal status over 10 years (visits 1-4)...
2016: Journal of the American Heart Association
Guillaume Vogin, François Golfier, Touria Hajri, Agnès Leroux, Béatrice Weber
BACKGROUND: HELLP syndrome is a combination of symptoms described as hemolysis, elevated liver enzymes and low platelets, that complicates 0.01-0.6 % of pregnancies. HELLP syndrome has been scarcely reported associated with partial moles, another rare complication of pregnancy. This manuscript describes the only reported case of HELLP syndrome associated with a complete invasive hydatiform mole. CASE PRESENTATION: We report a perimenopausal patient in prolonged remission from an uncommon high-risk invasive complete mole...
2016: BMC Cancer
Virginia A Aparicio, Pilar Ruiz-Cabello, Milkana Borges-Cosic, Ana Andrade, Irene Coll-Risco, Pedro Acosta-Manzano, Alberto Soriano-Maldonado
This study aimed to analyse the association of different components of physical fitness, body composition, cardiometabolic markers and the Mediterranean diet with bone mineral density (BMD) in perimenopausal women, and to test which of these components are independently associated with BMD. The sample comprised 197 perimenopausal women (52.6 ± 4.5 years). Physical fitness was assessed with the "Senior Fitness Test" battery and the handgrip strength and Bruce tests. Fat and lean mass and BMD were measured using dual-energy X-ray absorptiometry...
June 16, 2016: Journal of Sports Sciences
Dia Eddine Oudghiri, Pilar Ruiz-Cabello, Daniel Camiletti-Moirón, María Del Mar Fernández, Pilar Aranda, Virginia Ariadna Aparicio
INTRODUCTION: There is a lack of information about fitness and other health indicators in women from countries such as Morocco. This study aims to explore the association of weight status with physical and mental health in Moroccan perimenopausal women. METHODS: 151 women (45-65 years) from the North of Morocco were analyzed by standardized field-based fitness tests to assess cardiorespiratory fitness, muscular strength, flexibility, agility and balance. Quality of life was assessed by means of the Short-Form-36 Health Survey...
2016: Pan African Medical Journal
Agnieszka Olszanecka, Kalina Kawecka-Jaszcz, Danuta Czarnecka
INTRODUCTION: Data on the role of androgens as potential mediators of increasing cardiovascular risk in women at midlife are controversial. The aim of the study was to analyze the relationship of free testosterone (FT) and sex hormone binding globulin (SHBG) with blood pressure and subclinical organ damage and metabolic syndrome (MS) in middle aged hypertensive women. MATERIAL AND METHODS: One hundred and fifty-two women with newly diagnosed arterial hypertension were included in the study...
June 1, 2016: Archives of Medical Science: AMS
Bárbara Echiburú, Nicolás Crisosto, Manuel Maliqueo, Francisco Pérez-Bravo, Amanda Ladron de Guevara, Paola Hernández, Gabriel Cavada, Catalina Rivas, Andrés Clavel, Teresa Sir-Petermann
OBJECTIVE: To assess insulin sensitivity, insulin secretion and metabolic profile in women with polycystic ovary syndrome (PCOS) in different stages of reproductive life. MATERIALS AND METHODS: In a cross-sectional study, 190 PCOS women (PCOSw) and 99 controls (Cw) aged between 18 and 55years were included. PCOSw and Cw were distributed into 3 stages of reproductive life: early reproductive age (18-34years old), late reproductive age (35-40years old) and perimenopausal period (41-55years old)...
May 2016: Metabolism: Clinical and Experimental
Kun Ma, Yan-xia Chen
Perimenopausal syndrome refers to a series of physical and mental symptoms ,caused by the fluctuation of the sex hormones in the menopause, which is one of the common diseases in gynecology. With the acceleration of the aging population ir the world, it has caused the world's attention. Modern medicine has developed rapidly in the field of basic theory and clinical research, but there are still some problems in the treatment. Clinical treatment is mainly in hormone replacement therapy, but there are some potential risks, adverse reactions and many contraindications, thereby reducing patients' compliance and tolerance...
October 2015: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Cássia Raquel Teatin Juliato, Luiz Francisco Baccaro, Adriana Orcesi Pedro, Lucia Costa-Paiva, Jeffrey Lui-Filho, Aarão Mendes Pinto-Neto
AIMS: There are few population-based studies evaluating the epidemiology of overactive bladder syndrome (OAB) in women, especially in the climacteric stage where there is a decrease in estrogen production. This study aimed to assess the prevalence of OAB and associated factors in climacteric Brazilian women. METHODS: A descriptive, exploratory, cross-sectional study was conducted between September 2012 and June 2013 with 749 women (a population-based household survey)...
March 2016: Maturitas
Vincent T Martin, Jelena Pavlovic, Kristina M Fanning, Dawn C Buse, Michael L Reed, Richard B Lipton
OBJECTIVES: To examine the relationship of headache frequency to the stages of the menopausal transition in mid-life women with migraine. BACKGROUND: Past studies suggest that the perimenopause is associated with an increased prevalence of migraine, particularly in those with a history of premenstrual syndrome. The effect of the menopausal transition on the frequency of headache attacks in women with migraine has not been explored. METHODS: This was a cross-sectional observational study...
February 2016: Headache
Monica Fabbrini, Irene AricÃ, Francesco Tramonti, Rosaria Condurso, Luca Carnicelli, Anna De Rosa, Caterina Di Perri, Maria Rosaria Bonsignore, Anna Zito, Giovanna Russo, Maria Giovanna Pagliarulo, Biancamaria Guarnieri, Gianluigi Cerroni, Gianfranco Mennuni, Giacomo Della Marca, Enrica Bonanni, Rosalia Silvestri
Menopause in the female life cycle is a special period due to important hormonal, physical and psychological changes. Sleep disruption represents a common complaint for midlife and menopausal women, related to primary sleep disorders, including insomnia, sleep disordered breathing, restless legs syndrome (RLS), mood and anxiety disorder, other medical illness, hormonal-related vasomotor symptoms, and aging per se. Aims of our study were to evaluate the prevalence of sleep disorders in a sample of pre and post menopausal women, and to investigate the relationship between sleep and other medical disorders, and life habits...
June 2015: Archives Italiennes de Biologie
Deborah L Cartee, Shannon Maker, Debra Dalonges, Marion C Manski
PURPOSE: Sjögren's syndrome is a systemic autoimmune disease affecting approximately 3 million Americans, primarily perimenopausal women. The syndrome is characterized by dysfunction and destruction of exocrine glands leading to oral and ocular manifestations, xerostomia and keratitis sicca. Sjögren's syndrome commonly remains either undiagnosed or is diagnosed years after the onset of symptoms. Diagnosis is based on the concurrent presence of various signs and symptoms of the disease as established by 6 diagnostic standards set by the American European Consensus Group standards: oral symptoms, ocular symptoms, evidence of oral signs, evidence of ocular dryness, evidence of salivary gland involvement with positive Anti-Ro/La autoantibodies and a positive gland biopsy...
December 2015: Journal of Dental Hygiene: JDH
Sue Kim, Yunhee Ko, Gihong Yi
OBJECTIVE: Social determinants have been understudied in relation to metabolic risk and menopause; this study aimed to identify metabolic risk factors during menopausal transition, changes in lifestyle, and other social determinants. METHODS: The Korean Genetic Epidemiologic Survey Community cohort data available for baseline, 2-year, and 4-year follow-up time points were analyzed. Healthy women ages 45 to 55 years, not taking hormonal therapy, were selected; 1,228 were analyzed...
April 2016: Menopause: the Journal of the North American Menopause Society
Daniel A Dumesic, Sharon E Oberfield, Elisabet Stener-Victorin, John C Marshall, Joop S Laven, Richard S Legro
Polycystic ovary syndrome (PCOS) is a heterogeneous and complex disorder that has both adverse reproductive and metabolic implications for affected women. However, there is generally poor understanding of its etiology. Varying expert-based diagnostic criteria utilize some combination of oligo-ovulation, hyperandrogenism, and the presence of polycystic ovaries. Criteria that require hyperandrogenism tend to identify a more severe reproductive and metabolic phenotype. The phenotype can vary by race and ethnicity, is difficult to define in the perimenarchal and perimenopausal period, and is exacerbated by obesity...
October 2015: Endocrine Reviews
Monika Lenart-Lipińska, Beata Matyjaszek-Matuszek, Ewa Woźniakowska, Janusz Solski, Jerzy S Tarach, Tomasz Paszkowski
Polycystic ovary syndrome (PCOS), a hyperandrogenic disorder, is the commonest endocrinopathy in premenopausal women. This syndrome is associated with fertility problems, clinical manifestations of hyperandrogenism and metabolic disturbances, particularly insulin resistance and obesity. There is a great body of evidence that patients with PCOS present multiple cardiovascular risk factors and cluster components of metabolic syndrome from early ages. The presence of comorbidities such as abdominal obesity, insulin resistance, type 2 diabetes, hypertension places these females at an increased risk of future cardiovascular events...
December 2014: Przeglad Menopauzalny, Menopause Review
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