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https://www.readbyqxmd.com/read/28636503/effects-of-instructional-physical-activity-courses-on-overall-physical-activity-and-mood-in-university-students
#1
James J Annesi, Kandice J Porter, Grant M Hill, Bernard D Goldfine
PURPOSE: The aim of this research was to assess the association between university-based instructional physical activity (PA) courses and changes in overall PA levels and negative mood and their interrelations. The study also sought to determine the amount of change in PA required to significantly improve mood in course enrollees. METHOD: Participants were university students initially completing PA below the level recommended for health who were either presently enrolled in an elective instructional PA course (treatment group, n = 52, 69% female) or not presently enrolled in such a course (comparison group, n = 32, 69% female)...
June 21, 2017: Research Quarterly for Exercise and Sport
https://www.readbyqxmd.com/read/28635432/psychological-resilience-in-people-experiencing-schizophrenia-and-suicidal-thoughts-and-behaviours
#2
Patricia Ann Gooding, Donna Littlewood, Rebecca Owen, Judith Johnson, Nick Tarrier
BACKGROUND: Negative stressors can aggravate the impact of schizophrenia. However, some people find ways of combating such stressors. There is a dearth of research examining factors which enable individuals with schizophrenia to show psychological resilience. AIMS: The goal of this study was to investigate resilience to negative stressors in people with disorders on the schizophrenia spectrum using a qualitative methodology. METHODS: Data were collected from 23 participants who had experienced schizophrenia and suicidal thoughts and behaviours...
February 28, 2017: Journal of Mental Health
https://www.readbyqxmd.com/read/28634255/population-genetic-structure-of-bromus-tectorum-in-the-mountains-of-western-north-america
#3
Spencer Arnesen, Craig E Coleman, Susan E Meyer
PREMISE OF THE STUDY: Invasive species are often initially restricted to a narrow range and may then expand through any of multiple mechanisms including phenotypic plasticity, in situ evolution, or selection on traits preadapted for new habitats. Our study used population genetics to explore possible processes by which the highly selfing invasive annual grass Bromus tectorum has expanded into montane environments. METHODS: We used 69 single nucleotide polymorphic (SNP) markers to genotype ca...
June 20, 2017: American Journal of Botany
https://www.readbyqxmd.com/read/28626006/atairp2-e3-ligase-affects-aba-and-high-salinity-responses-by-stimulating-its-atp1-sdirip1-substrate-turnover
#4
Tae Rin Oh, Jong Hum Kim, Seok Keun Cho, Moon Young Ryu, Seong Wook Yang, Woo Taek Kim
AtAIRP2 is a cytosolic RING-type E3 ubiquitin (Ub) ligase that positively regulates an ABA response in Arabidopsis (Arabidopsis thaliana). Yeast two-hybrid screening using AtAIRP2 as bait identified ATP1 (AtAIRP2 Target Protein 1) as a substrate of AtAIRP2. ATP1 was found to be identical to SDIRIP1, which was recently reported to be a negative factor in ABA signaling and a target protein of the RING E3 ligase SDIR1. ATP1 was accordingly renamed ATP1/SDIRIP1. A specific interaction between AtAIRP2 and ATP1/SDIRIP1 and ubiquitination of ATP1/SDIRIP1 by AtAIRP2 were demonstrated in vitro and in planta...
June 16, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28621624/use-of-telomerase-promoter-mutations-to-mark-specific-molecular-subsets-with-reciprocal-clinical-behavior-in-idh-mutant-and-idh-wild-type-diffuse-gliomas
#5
Cemaliye B Akyerli, Şirin Yüksel, Özge Can, E Zeynep Erson-Omay, Yavuz Oktay, Erdal Coşgun, Ege Ülgen, Yiğit Erdemgil, Aydın Sav, Andreas von Deimling, Murat Günel, M Cengiz Yakıcıer, M Necmettin Pamir, Koray Özduman
OBJECTIVE Recent studies have established that hemispheric diffuse gliomas may be grouped into subsets on the basis of molecular markers; these subsets are loosely correlated with the histopathological diagnosis but are strong predictors of clinical tumor behavior. Based on an analysis of molecular and clinical parameters, the authors hypothesized that mutations of the telomerase promoter (TERTp-mut) mark separate oncogenic programs among isocitrate dehydrogenase 1 and/or 2 (IDH) mutant (IDH-mut) and IDH wild-type (IDH-wt) diffuse gliomas independent of histopathology or WHO grade...
June 16, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28617439/cdc20-directs-proteasome-mediated-degradation-of-the-tumor-suppressor-smar1-in-higher-grades-of-cancer-through-the-anaphase-promoting-complex
#6
Debasish Paul, Suvankar Ghorai, U S Dinesh, Praveenkumar Shetty, Samit Chattopadhyay, Manas Kumar Santra
The Tumor suppressor SMAR1 (scaffold matrix attachment region binding protein 1) has a crucial role in maintaining genomic stability, cell cycle progression and apoptosis.Our previous finding showed that it is highly suppressed in higher grade of cancer. However, the underlying mechanism of this suppression was not well understood. In this study, we show that SMAR1 expression levels are controlled at the proteasomal level by five RING finger E3 ubiquitin ligases including, Cdc20, a substrate receptor of ubiquitin ligase APC/C complex...
June 15, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28608419/empathic-responding-in-preschool-aged-children-with-familial-risk-for-autism
#7
Nicole M McDonald, Haley G Murphy, Daniel S Messinger
Individuals with autism spectrum disorder (ASD) show deficits in social and emotional reciprocity, which often include empathic responding. The younger siblings of children with ASD (high-risk siblings) are at elevated risk for ASD and for subclinical deficits in social-emotional functioning. Higher levels of empathy in high-risk siblings during the second and third years of life predict fewer ASD symptoms and likelihood of diagnosis. We conducted a multi-method investigation of empathic responding to an examiner's accident in 30 low-risk and 48 high-risk siblings with (n = 12) and without ASD outcomes (n = 36) at 4-6 years of age...
June 12, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28608021/prey-diversity-effects-on-ecosystem-functioning-depend-on-consumer-identity-and-prey-composition
#8
Daniel Wohlgemuth, Joanna Filip, Helmut Hillebrand, Stefanie D Moorthi
Consumer diversity effects on ecosystem functioning are highly context dependent and are determined by consumer specialization and other consumer and prey specific traits such as growth and grazing rates. Despite complex reciprocal interactions between consumers and their prey, few experimental studies have focused on prey diversity effects on consumer dynamics and trophic transfer. In microbial microcosms, we investigated effects of algal prey diversity (one, two and four species) on the production, evenness and grazing rates of 4 ciliate consumers, differing in grazing preferences and rates...
June 13, 2017: Oecologia
https://www.readbyqxmd.com/read/28598318/paracoccus-hibisci-sp-nov-isolated-from-the-rhizosphere-of-hibiscus-syriacus-l-mugunghwa-flower
#9
Zheng-Fei Yan, Gabriela Moya, Pei Lin, Kyung-Hwa Won, Jung-Eun Yang, Chang-Tian Li, MooChang Kook, Qi-Jun Wang, Tae-Hoo Yi
A Gram-stain-negative, aerobic, short-rod-shaped bacterium, motile by means of one flagellum (THG-T2.8T), was isolated from the rhizosphere of Mugunghwa flower. Growth occurred at 10-37 °C (optimum 28 °C), at pH 6-8 (optimum 7) and with 0-5 % NaCl (optimum 1 %). The major quinone was ubiquinone-10 (Q-10). The major fatty acids were C10 : 0 3-OH, C16 : 0, C18 : 0 and C18 : 1ω7c. The polar lipids were diphosphatidylglycerol, phosphatidylmethylethanolamine, phosphatidylethanolamine, phosphatidylglycerol, one unidentified aminolipid, two unknown phospholipids, one unknown glycolipid and one unidentified lipid...
June 9, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28596757/time-resolved-tracking-of-mutations-reveals-diverse-allele-dynamics-during-escherichia-coli-antimicrobial-adaptive-evolution-to-single-drugs-and-drug-pairs
#10
Rachel A Hickman, Christian Munck, Morten O A Sommer
Understanding the evolutionary processes that lead to antibiotic resistance can help to achieve better treatment strategies. Yet, little is known about the dynamics of the resistance alleles during adaptation. Here, we use population sequencing to monitor genetic changes in putative resistance loci at several time-points during adaptive evolution experiments involving five different antibiotic conditions. We monitor the mutational spectra in lineages evolved to be resistant to single antibiotics [amikacin (AMK), chloramphenicol (CHL), and ciprofloxacin (CIP)], as well as antibiotic combinations (AMK + CHL and CHL + CIP)...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28594233/own-and-partners-dyadic-coping-and-depressive-symptoms-in-individuals-with-early-stage-dementia-and-their-caregiving-partners
#11
Paul Gellert, Andreas Häusler, Maryam Gholami, Michael Rapp, Adelheid Kuhlmey, Johanna Nordheim
OBJECTIVES: In patients with early-stage dementia and their caregiving partners, reciprocal dyadic coping (DC) is crucial for preventing or reducing depressive symptoms in both partners. This study examines the relationships between 'own DC' and 'perceived partner DC' with depressive symptoms in couples coping with dementia on individual (actor effects) and cross-person (partner effects) levels. METHOD: 164 individuals (82 patients with early-stage dementia and their 82 caregiving partners; ND = 82 dyads) participated in this prospective study with measures (DC, depressive symptoms, and dementia severity) taken at baseline and at six months...
June 8, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/28580021/a-cognitive-distortions-and-deficits-model-of-suicide-ideation
#12
Laura L Fazakas-DeHoog, Katerina Rnic, David J A Dozois
Although cognitive distortions and deficits are known risk factors for the development and escalation of suicide ideation and behaviour, no empirical work has examined how these variables interact to predict suicide ideation. The current study proposes an integrative model of cognitive distortions (hopelessness and negative evaluations of self and future) and deficits (problem solving deficits, problem solving avoidance, and cognitive rigidity). To test the integrity of this model, a sample of 397 undergraduate students completed measures of deficits, distortions, and current suicide ideation...
May 2017: Europe's journal of psychology
https://www.readbyqxmd.com/read/28576290/comparing-acceptance-and-rejection-in-the-classroom-interaction-of-students-who-stutter-and-their-peers-a-social-network-analysis
#13
Stefanie Adriaensens, Sara Van Waes, Elke Struyf
PURPOSE: Recent work has reported adverse effects of students' stuttering on their social and emotional functioning at school. Yet, few studies have provided an in-depth examination of classroom interaction of students who stutter (SWS). The current study uses a network perspective to compare acceptance and rejection in the classroom interaction between SWS and their peers in secondary education. METHODS: The sample comprised 22 SWS and 403 non-stuttering peers (22 classes) of secondary education in Flanders (Belgium)...
June 2017: Journal of Fluency Disorders
https://www.readbyqxmd.com/read/28565812/increased-runx2-expression-associated-with-enhanced-wnt-signaling-in-pdlla-internal-fixation-for-fracture-treatment
#14
Zhuoyan Ling, Lei Wu, Gaolong Shi, Li Chen, Qirong Dong
Poly-D-L lactide (PDLLA) biodegradable implants to heal fractures are widely applied in orthopedic surgeries. However, whether the process of fracture healing is regulated differently when PDLLA is used compared with traditional metal materials remains unclear. Runt-related transcription factor 2 (Runx2) and canonical Wnt signaling are essential and may interact reciprocally in the regulation of osteogenesis during bone repair. In the present study, a rat femoral open osteotomy model was used to compare the curative efficacy of a PDLLA rod and Kirschner wire under intramedullary fixation for fracture treatment...
May 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28562593/frequency-dependence-limits-divergent-evolution-by-favouring-rare-immigrants-over-residents
#15
Daniel I Bolnick, William E Stutz
Two distinct forms of natural selection promote adaptive biological diversity. Divergent selection occurs when different environments favour different phenotypes, leading to increased differences between populations. Negative frequency-dependent selection occurs when rare variants within a population are favoured over common ones, increasing diversity within populations. These two diversifying forces promote genetic variation at different spatial scales, and may act in opposition, but their relative effects remain unclear because they are rarely measured concurrently...
June 8, 2017: Nature
https://www.readbyqxmd.com/read/28560387/reciprocal-antagonistic-regulation-of-n-myc-mrna-by-mir%C3%A2-17-and-the-neuronal-specific-rna-binding-protein-hud
#16
Leleesha Samaraweera, Barbara A Spengler, Robert A Ross
Neuroblastoma is a childhood cancer originating from embryonic neural crest cells. Amplification of the proto‑oncogene N-myc, seen in ~30% of neuroblastoma tumors, is a marker for poor prognosis. Recently discovered small regulatory RNAs, microRNAs (miRNAs), are implicated in cancers, including neuroblastoma. miRNAs downregulate the expression of genes by binding to the 3'-untranslated regions (3'-UTRs), thereby inhibiting translation or inducing degradation of cognate mRNAs. Our study sought to identify miRNAs that regulate N-myc expression and thereby malignancy in neuroblastoma...
May 24, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28556511/host-specific-effects-of-soil-microbial-filtrates-prevail-over-those-of-arbuscular-mycorrhizae-in-a-fragmented-landscape
#17
Camila Pizano, Scott A Mangan, James H Graham, Kaoru Kitajima
Plant-soil interactions have been shown to determine plant community composition in a wide range of environments. However, how plants distinctly interact with beneficial and detrimental organisms across mosaic landscapes containing fragmented habitats is still poorly understood. We experimentally tested feedback responses between plants and soil microbial communities from adjacent habitats across a disturbance gradient within a human-modified tropical montane landscape. In a greenhouse experiment, two components of soil microbial communities were amplified; arbuscular mycorrhizal fungi (AMF) and a filtrate excluding AMF spores from the soils of pastures (high disturbance), coffee plantations (intermediate disturbance), and forest fragments (low disturbance), using potted seedlings of 11 plant species common in these habitats (pasture grass, coffee, and 9 native species)...
May 28, 2017: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/28551334/structure-and-dimerization-of-ireb-a-negative-regulator-of-cephalosporin-resistance-in-enterococcus-faecalis
#18
Cherisse L Hall, Betsy L Lytle, Davin Jensen, Jessica S Hoff, Francis C Peterson, Brian F Volkman, Christopher J Kristich
Enterococcus faecalis, a leading cause of hospital-acquired infections, exhibits intrinsic resistance to most cephalosporins, which are antibiotics in the beta-lactam family that target cell-wall biosynthesis. A comprehensive understanding of the underlying genetic and biochemical mechanisms of cephalosporin resistance in E. faecalis is lacking. We previously determined that a transmembrane serine-threonine kinase (IreK) and its cognate phosphatase (IreP) reciprocally regulate cephalosporin resistance in E...
May 24, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/28548128/genomic-profiling-of-breast-secretory-carcinomas-reveals-distinct-genetics-from-other-breast-cancers-and-similarity-to-mammary-analog-secretory-carcinomas
#19
Gregor Krings, Nancy M Joseph, Gregory R Bean, David Solomon, Courtney Onodera, Eric Talevich, Iwei Yeh, James P Grenert, Elizabeth Hosfield, Emily D Crawford, Richard C Jordan, Annemieke van Zante, Charles Zaloudek, Sandra J Shin, Yunn-Yi Chen
Secretory carcinomas of the breast are rare tumors with distinct histologic features, recurrent t(12;15)(p13;q25) translocation resulting in ETV6-NTRK3 gene fusion and indolent clinical behavior. Mammary analog secretory carcinomas arising in other sites are histopathologically similar to the breast tumors and also harbor ETV6-NTRK3 fusions. Breast secretory carcinomas are often triple (estrogen and progesterone receptor, HER2) negative with a basal-like immunophenotype. However, genomic studies are lacking, and whether these tumors share genetic features with other basal and/or triple negative breast cancers is unknown...
May 26, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28544356/older-people-s-experiences-of-falling-and-perceived-risk-of-falls-in-the-community-a-narrative-synthesis-of-qualitative-research
#20
REVIEW
Siobhan Gardiner, Margaret Glogowska, Catherine Stoddart, Sarah Pendlebury, Daniel Lasserson, Debra Jackson
AIM: To examine qualitative research exploring older people's experiences of falling and the perceived risk of falling in the community. This will contribute new insights into how falling is perceived by the older community. BACKGROUND: Falls are a major problem for older people and healthcare services across the world. Accidental falls in the community are a persistent problem that is generally recognised as an intrinsic risk of ageing. This review provides a new synthesis of evidence that considers older people's perception of falls in the community as new insights are needed if the increasing problems of falls are to be addressed...
May 22, 2017: International Journal of Older People Nursing
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