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Negative reciprocity

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https://www.readbyqxmd.com/read/29142263/hyaluronic-acid-35-normalizes-tlr4-signaling-in-kupffer-cells-from-ethanol-fed-rats-via-regulation-of-microrna291b-and-its-target-tollip
#1
Paramananda Saikia, Sanjoy Roychowdhury, Damien Bellos, Katherine A Pollard, Megan R McMullen, Rebecca L McCullough, Arthur J McCullough, Pierre Gholam, Carol de la Motte, Laura E Nagy
TLR4 signaling in hepatic macrophages is increased after chronic ethanol feeding. Treatment of hepatic macrophages after chronic ethanol feeding with small-specific sized hyaluronic acid 35 (HA35) normalizes TLR4 signaling; however, the mechanisms for HA35 action are not completely understood. Here we used Next Generation Sequencing of microRNAs to identify negative regulators of TLR4 signaling reciprocally modulated by ethanol and HA35 in hepatic macrophages. Eleven microRNAs were up-regulated by ethanol; only 4 microRNAs, including miR291b, were decreased by HA35...
November 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29141593/bidirectional-alteration-of-cav-1-expression-is-associated-with-mitogenic-conversion-of-its-function-in-gastric-tumor-progression
#2
Byung-Kyu Ryu, Min-Goo Lee, Nam-Hoon Kim, Kil Yeon Lee, Shin-Ju Oh, Jung-Rock Moon, Hyo Jong Kim, Sung-Gil Chi
BACKGROUND: Expression of caveolin-1 (Cav-1) is frequently altered in many human cancers and both tumor suppression and promotion functions of Cav-1 have been suggested based on its expression status. However, it remains unanswered how Cav-1 provokes opposite effects in different cancers or different phases of tumor progression. METHODS: To explore the implication of Cav-1 alteration in gastric tumorigenesis, the expression and mutational status of Cav-1 and its effects on tumor cell growth were characterized...
November 15, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29138272/the-role-of-peers-for-diabetes-management-in-adolescents-and-emerging-adults-with-type-1-diabetes-a-longitudinal-study
#3
Koen Raymaekers, Leen Oris, Sofie Prikken, Philip Moons, Eva Goossens, Ilse Weets, Koen Luyckx
OBJECTIVE: The increasing importance of peers in adolescence and emerging adulthood has been widely acknowledged. However, longitudinal research linking the peer context to diabetes management and outcomes is scarce. The present longitudinal study in a large sample of youths with type 1 diabetes related both positive and negative peer variables to diabetes outcomes over a time interval of 1 year. RESEARCH DESIGN AND METHODS: Our sample consisted of 467 adolescents (14-17 years of age) and emerging adults (18-25 years of age) with type 1 diabetes who participated in a two-wave longitudinal study...
November 14, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29128195/-what-support-of-young-presenting-a-first-psychotic-episode-when-schooling-is-being-challenged
#4
M-N Vacheron, H Veyrat-Masson, E Wehbe
Psychiatric disorders (more specifically mood disorders and psychosis) represent the 1st cause of disability among young people. Unemployment rate between 75 to 95% for the person with schizophrenia. It is correlated to poor social integration and bad economic status, worse symptomatology loss of autonomy as well as global bad functioning. It is responsible of more than half of the overall cost of psychosis. The onset of most of psychiatric disorders occur between the age of 25 and 35 years old, a critical time in young adult life when they should build their professional as well as social future...
November 8, 2017: L'Encéphale
https://www.readbyqxmd.com/read/29121671/separating-conditional-and-unconditional-cooperation-in-a-sequential-prisoner-s-dilemma-game
#5
Raoul Bell, Laura Mieth, Axel Buchner
Most theories of social exchange distinguish between two different types of cooperation, depending on whether or not cooperation occurs conditional upon the partner's previous behaviors. Here, we used a multinomial processing tree model to distinguish between positive and negative reciprocity and cooperation bias in a sequential Prisoner's Dilemma game. In Experiments 1 and 2, the facial expressions of the partners were varied to manipulate cooperation bias. In Experiment 3, an extinction instruction was used to manipulate reciprocity...
2017: PloS One
https://www.readbyqxmd.com/read/29115574/long-non-coding-rna-snhg1-regulates-nob1-expression-by-sponging-mir-326-and-promotes-tumorigenesis-in-osteosarcoma
#6
Jiandong Wang, Lei Cao, Jianhong Wu, Qiugen Wang
The long non-coding RNA (lncRNA) small nucleolar RNA host gene 1 (SNHG1) has been demonstrated to participate in the deterioration of many types of cancer. However, the underlying mechanisms of SNHG1-mediating functions in osteosarcoma (OS) have yet to be elucidated. In the present study, our results showed that SNHG1 was upregulated in OS tissues and cell lines, and high SNHG1 expression predicts poor overall survival of OS patients. Knockdown of SNHG1 inhibited cell growth and metastasis of OS in vitro and in vivo...
November 3, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29113896/neuroinflammation-produced-by-heavy-alcohol-intake-is-due-to-loops-of-interactions-between-toll-like-4-and-tnf-receptors-peroxisome-proliferator-activated-receptors-and-the-central-melanocortin-system-a-novel-hypothesis-and-new-therapeutic-avenues
#7
Osvaldo Flores-Bastías, Eduardo Karahanian
Excessive alcohol intake induces an inflammatory response in the brain, via TNFα, TLR4 and NF-κB signaling pathways. It has been proposed that neuroinflammation would play a very important role in the development of alcohol addiction. In addition to stimulating the synthesis of inflammatory mediators such as IL-6, IL-1β and TNFα, NF-κB is capable of reducing the anti-inflammatory activity of PPARα and PPARγ. Reciprocally, PPARα, PPARγ and melanocortin 4 receptor (MC4R) can decrease the proinflammatory activity of NF-κB, establishing an interplay of inactivations between such nuclear factors and receptors...
November 4, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29080089/downregulation-of-p53-drives-autophagy-during-human-trophoblast-differentiation
#8
Martin Gauster, Sabine Maninger, Monika Siwetz, Alexander Deutsch, Amin El-Heliebi, Dagmar Kolb-Lenz, Ursula Hiden, Gernot Desoye, Florian Herse, Andreas Prokesch
The placental barrier is crucial for the supply of nutrients and oxygen to the developing fetus and is maintained by differentiation and fusion of mononucleated cytotrophoblasts into the syncytiotrophoblast, a process only partially understood. Here transcriptome and pathway analyses during differentiation and fusion of cultured trophoblasts yielded p53 signaling as negative upstream regulator and indicated an upregulation of autophagy-related genes. We further showed p53 mRNA and protein levels decreased during trophoblast differentiation...
October 27, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/29079737/mir-1199-5p-and-zeb1-function-in-a-double-negative-feedback-loop-potentially-coordinating-emt-and-tumour-metastasis
#9
Maren Diepenbruck, Stefanie Tiede, Meera Saxena, Robert Ivanek, Ravi Kiran Reddy Kalathur, Fabiana Lüönd, Nathalie Meyer-Schaller, Gerhard Christofori
Epithelial tumour cells can gain invasive and metastatic capabilities by undergoing an epithelial-mesenchymal transition. Transcriptional regulators and post-transcriptional effectors like microRNAs orchestrate this process of high cellular plasticity and its malignant consequences. Here, using microRNA sequencing in a time-resolved manner and functional validation, we have identified microRNAs that are critical for the regulation of an epithelial-mesenchymal transition and of mesenchymal tumour cell migration...
October 27, 2017: Nature Communications
https://www.readbyqxmd.com/read/29078399/reciprocal-cross-regulation-of-vnd-and-snd-multigene-tf-families-for-wood-formation-in-populus-trichocarpa
#10
Ying-Chung Jimmy Lin, Hao Chen, Quanzi Li, Wei Li, Jack P Wang, Rui Shi, Sermsawat Tunlaya-Anukit, Peng Shuai, Zhifeng Wang, Hongyan Ma, Huiyu Li, Ying-Hsuan Sun, Ronald R Sederoff, Vincent L Chiang
Secondary cell wall (SCW) biosynthesis is the biological process that generates wood, an important renewable feedstock for materials and energy. NAC domain transcription factors, particularly Vascular-Related NAC-Domain (VND) and Secondary Wall-Associated NAC Domain (SND) proteins, are known to regulate SCW differentiation. The regulation of VND and SND is important to maintain homeostasis for plants to avoid abnormal growth and development. We previously identified a splice variant, PtrSND1-A2(IR) , derived from PtrSND1-A2 as a dominant-negative regulator, which suppresses the transactivation of all PtrSND1 family members...
October 23, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29076568/the-reciprocal-relationship-between-daily-fatigue-and-catastrophizing-following-cancer-treatment-affect-and-physical-activity-as-potential-mediators
#11
Fabiola Müller, Ellen Stephenson, Anita DeLongis, Ans Smink, Robert J Van Ginkel, Marrit A Tuinman, Mariët Hagedoorn
OBJECTIVE: Fatigue is a distressing symptom many cancer patients experience even after completion of treatment. Although theory and empirical evidence indicate that negative cognitions perpetuate fatigue after completion of treatment, insight into how this process unfolds in daily life is limited. This study used an intensive longitudinal design to investigate the reciprocal relationship between catastrophizing and fatigue in daily life and whether affective and behavioral processes mediate these relationships...
October 27, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/29070895/language-lateralization-during-the-chinese-semantic-task-relates-to-the-contralateral-cerebra-cerebellar-interactions-at-rest
#12
Qing Gao, Zhongping Tao, Lintao Cheng, Jinsong Leng, Junping Wang, Chunshui Yu, Huafu Chen
Aiming to investigate whether handedness-related language lateralization is related to the intrinsic resting-state functional connectivity (RSFC) pattern within the language network, the present study integrated the information of functional activations during a semantic task of Chinese characters and FC in resting-state based on functional magnetic resonance imaging (fMRI) data of healthy left handers (LH) and right handers (RH). RSFC was calculated on a voxel-based level between the seed regions chosen from functional activations during the task and the rest of the brain...
October 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29058658/winogradskyella-haliclonae-sp-nov-isolated-from-a-marine-sponge-of-the-genus-haliclona
#13
Johannes Schellenberg, Hans-Jürgen Busse, Martin Hardt, Patrick Schubert, Thomas Wilke, Peter Kämpfer, Stefanie P Glaeser
A yellow-pigmented, Gram-stain-negative, motile and rod-shaped bacterium, strain M1A16(T), was isolated from the internal tissue of a sponge of the genus Haliclona, which was long-term cultured in the CEMarin aquaria system at Justus Liebig University of Giessen. The strain grew well at 20-32 °C (optimum 25 °C), in the presence of 0-6 % NaCl (optimum 3 %), and at pH 5.5-9.0 (optimum pH 7.0-8.0). Phylogenetic analysis based on its 16S rRNA gene sequence placed the strain within the monophyletic cluster of the genus Winogradskyella with highest sequence similarity to Winogradskyella jejuensis CP32(T) (98...
October 23, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/29055966/comparison-between-unilateral-pnif-and-rhinomanometry-in-the-evaluation-of-nasal-cycle
#14
A L Pendolino, E Nardello, V J Lund, P Maculan, B Scarpa, A Martini, G Ottaviano
BACKGROUND: Human unilateral nasal airflow shows spontaneous changes over a period of hours due to the alternating congestion and decongestion of the venous sinuses within the nasal turbinates and nasal septum. The aim of the present study was to compare PNIF and unilateral PNIF with nasal resistances measured by means of AAR in the evaluation of the nasal cycle. METHODS: PNIF, unilateral PNIF and AAR measurements were randomly performed in 20 non-smokers, non-asthmatic volunteers, with a SNOT 22 score lower than 1...
October 22, 2017: Rhinology
https://www.readbyqxmd.com/read/29045485/alterations-in-the-placental-methylome-with-maternal-obesity-and-evidence-for-metabolic-regulation
#15
Kohzoh Mitsuya, Ashley N Parker, Lu Liu, Jianhua Ruan, Margreet C M Vissers, Leslie Myatt
The inflammatory and metabolic derangements of obesity in pregnant women generate an adverse intrauterine environment, increase pregnancy complications and adverse fetal outcomes and program the fetus for obesity and metabolic syndrome in later life. We hypothesized that epigenetic modifications in placenta including altered DNA methylation/hydroxymethylation may mediate these effects. Term placental villous tissue was collected following cesarean section from lean (prepregnancy BMI<25) or obese (BMI>30) women...
2017: PloS One
https://www.readbyqxmd.com/read/29044571/sensitivity-of-sorghum-pollen-and-pistil-to-high-temperature-stress
#16
M Djanaguiraman, R Perumal, S V K Jagadish, I A Ciampitti, R Welti, P V V Prasad
High temperature (HT) decreases seed-set percentage in sorghum [Sorghum bicolor (L.) Moench]. The relative sensitivity of pollen and particularly pistil and the mechanistic response that induces tolerance or susceptibility to HT is not well known and hence is the major objective of this research. The male sterile (ATx399) and fertile (RTx430) lines were exposed to 30/20 °C (optimum temperature; OT), 36/26 °C (HT1 ) and 39/29 °C (HT2 ) from the start of booting to seed-set in a controlled environment. Similarly, in the field, HT stress was imposed using heat tents...
October 18, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/29040605/negative-assortative-mating-in-the-white-throated-sparrow
#17
Philip W Hedrick, Elaina M Tuttle, Rusty A Gonser
Non-random mating based on phenotype has been observed in a number of organisms, but a very high proportion of these examples are of assortative mating. The strongest example of negative-assortative mating is for white-striped versus tan-striped crown in the white-throated sparrow, where about 98% of the observed pairings (mated pairs or social pairs) are between mates with different phenotypes and the correlation between mating types is -0.964. Although non-random mating has been explored theoretically for decades, these models have generally not focused on specific well-documented examples...
October 10, 2017: Journal of Heredity
https://www.readbyqxmd.com/read/29038862/examining-spatial-patterns-of-selection-and-use-for-an-altered-predator-guild
#18
Matthew A Mumma, Joseph D Holbrook, Nathaniel D Rayl, Christopher J Zieminski, Todd K Fuller, John F Organ, Shane P Mahoney, Lisette P Waits
Anthropogenic disturbances have altered species' distributions potentially impacting interspecific interactions. Interference competition is when one species denies a competing species access to a resource. One mechanism of interference competition is aggression, which can result in altered space-use of a subordinate species due to the threat of harm, otherwise known as a 'landscape of fear'. Alternatively, subordinates might outcompete dominant species in resource-poor environments via a superior ability to extract resources...
December 2017: Oecologia
https://www.readbyqxmd.com/read/29030964/transcription-factor-hmg-box-containing-protein-1-hbp1-modulates-mitotic-clonal-expansion-mce-during-adipocyte-differentiation
#19
Chien-Yi Chan, Ping Yu, Feng-Tzu Chang, Zih-Hua Chen, Ming-Fen Lee, Chun-Yin Huang
Transcription factor HMG box-containing protein 1 (HBP1) has been found to be up-regulated in rat adipose tissue and differentiated preadipocyte; however, how HBP1 is involved in adipocyte formation remains unclear. In the present study, we demonstrated that under a standard differentiation protocol HBP1 expression fluctuates with down-regulation in the mitotic clonal expansion (MCE) stage followed by up-regulation in the terminal differentiation stage in both 3T3-L1 and MEF cell models. Also, HBP1 knockdown accelerated cell cycle progression in the MCE stage, but it impaired final adipogenesis...
October 14, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29026702/apical-extrusion-of-intracanal-bacteria-with-single-file-and-multifile-rotary-instrumentation-systems
#20
Eshaghali Saberi, Shahram Shahraki Zahedani, Sediqe Ebrahimipour
AIMS AND OBJECTIVES: Instrumentation techniques may cause extrusion of microorganisms and their products into the periapical region resulting inflammation and treatment failure. The aim of this ex vivo study was comparing the apical bacterial extrusion in canals prepared with single file versus multiple file rotary systems. MATERIALS AND METHODS: Ninety-two human single-rooted mandibular first premolars were used. Endodontic access cavities were prepared, and root canals were contaminated with an Enterococcus faecalis (E...
September 2017: Journal of International Society of Preventive & Community Dentistry
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