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https://www.readbyqxmd.com/read/28523966/relationship-centered-dementia-care-insights-from-a-community-based-culture-change-coalition
#1
Lorna de Witt, Darla Fortune
This article reports on the work of a community-based culture change coalition affiliated with the Partnerships in Dementia Care Alliance, a research network committed to strengthening dementia care through supporting relationship-centered care approaches. Research to date emphasizes negative aspects of dementia care relationships. Drawing on data the culture change coalition collected as part of their culture change work using participatory action research guided by appreciative inquiry, this article examines what relationship qualities contributed to positive dementia care experiences and how positive relationships were created...
January 1, 2017: Dementia
https://www.readbyqxmd.com/read/28513185/moderate-dementia-relational-social-engagement-rse-during-family-visits
#2
Bruce Walmsley, Lynne McCormack
OBJECTIVE: This qualitative study seeks evidence of retained social awareness in individuals with moderate dementia residing in care-homes, when engaged in interactive family visits. METHOD: Speech/non-speech data collected from 10/15-minute video-recorded family interactions of five family groups (12 individuals; 2 sessions per family group) were coded using thematic analysis. RESULTS: Interactional patterns embedded in familiar bonds provided the context for the superordinate theme: relational social engagement (RSE)...
May 17, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/28503475/the-use-of-auxiliary-devices-during-irrigation-to-increase-the-cleaning-ability-of-a-chelating-agent
#3
Marina Carvalho Prado, Fernanda Leal, Renata Antoun Simão, Heloisa Gusman, Maíra do Prado
OBJECTIVES: This study investigated the cleaning ability of ultrasonically activated irrigation (UAI) and a novel activation system with reciprocating motion (EC, EasyClean, Easy Equipamentos Odontológicos) when used with a relatively new chelating agent (QMix, Dentsply). In addition, the effect of QMix solution when used for a shorter (1 minute) and a longer application time (3 minutes) was investigated. MATERIALS AND METHODS: Fifty permanent human teeth were prepared with K3 rotary system and 6% sodium hypochlorite...
May 2017: Restorative Dentistry & Endodontics
https://www.readbyqxmd.com/read/28501597/reciprocal-regulation-between-hepcidin-and-erythropoiesis-and-its-therapeutic-application-in-erythroid-disorders
#4
REVIEW
Caiyi Wang, Zheng Fang, Zesen Zhu, Jing Liu, Huiyong Chen
Iron is required for hemoglobin production, and it plays a key role during erythropoiesis. Systemic iron homeostasis is mainly negatively regulated by the peptide hormone hepcidin, coded by the gene HAMP. Hepcidin excess may cause iron deficiency, iron-restricted erythropoiesis and anemia. Conversely, hepcidin insufficiency leads to iron overload and oxidative damage in multiple tissues. During regulation of hepcidin synthesis, multiple promoter elements in the HAMP gene respond to variable signaling pathways corresponding to different extracellular situations...
May 10, 2017: Experimental Hematology
https://www.readbyqxmd.com/read/28494439/centromere-repositioning-in-cattle-bos-taurus-chromosome-17
#5
Lisa De Lorenzi, Alessandra Iannuzzi, Elena Rossi, Stefania Bonacina, Pietro Parma
Eukaryotic organisms have developed a structure, called centromere, able to preserve the integrity of the genome during cell division. A young bull from the Marchigiana breed, with a normal external phenotype, underwent routine cytogenetic analysis to enter the reproduction center. All metaphases analyzed showed an unusual biarmed chromosome of medium size despite a diploid set of chromosomes (2n = 60,XY). FISH analysis excluded a pericentric inversion or a reciprocal translocation, but highlighted a repositioning of the centromere in BTA17...
May 12, 2017: Cytogenetic and Genome Research
https://www.readbyqxmd.com/read/28493844/mirnas-and-e2f3-a-complex-network-of-reciprocal-regulations-in-human-cancers
#6
REVIEW
Yanping Gao, Bing Feng, Lu Lu, Siqi Han, Xiaoyuan Chu, Longbang Chen, Rui Wang
E2F transcription factor 3 (E2F3) is oncogenic in tumorigenesis. Alterations in E2F3 functions correspond with poor prognosis in various cancers, underscoring their status for the clinical cancer phenotype. Latest reports discovered intricate networks between microRNAs (miRNAs) and E2F3 in regulating the balance of these events, including proliferation, apoptosis, metastasis, as well as drug resistance. miRNAs are non-coding small RNAs which negatively regulate gene expressions post-transcriptionally mainly through 3'-UTR binding of target mRNAs...
April 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28487511/a-local-counter-regulatory-motif-modulates-the-global-phase-of-hormonal-oscillations
#7
Dong-Ho Park, Taegeun Song, Danh-Tai Hoang, Jin Xu, Junghyo Jo
Counter-regulatory elements maintain dynamic equilibrium ubiquitously in living systems. The most prominent example, which is critical to mammalian survival, is that of pancreatic α and β cells producing glucagon and insulin for glucose homeostasis. These cells are not found in a single gland but are dispersed in multiple micro-organs known as the islets of Langerhans. Within an islet, these two reciprocal cell types interact with each other and with an additional cell type: the δ cell. By testing all possible motifs governing the interactions of these three cell types, we found that a unique set of positive/negative intra-islet interactions between different islet cell types functions not only to reduce the superficially wasteful zero-sum action of glucagon and insulin but also to enhance/suppress the synchronization of hormone secretions between islets under high/normal glucose conditions...
May 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28479653/cognitive-appraisals-of-alcohol-use-in-early-adolescence-psychosocial-predictors-and-reciprocal-associations-with-alcohol-use
#8
Craig R Colder, Jennifer P Read, William F Wieczorek, Rina D Eiden, Liliana J Lengua, Larry W Hawk, Elisa M Trucco, Hector I Lopez-Vergara
Early adolescence is a dynamic period for the development of alcohol appraisals (expected outcomes of drinking and subjective evaluations of expected outcomes), yet the literature provides a limited understanding of psychosocial factors that shape these appraisals during this period. This study took a comprehensive view of alcohol appraisals and considered positive and negative alcohol outcome expectancies, as well as subjective evaluations of expected outcomes. Developmental-ecological theory guided examination of individual, peer, family, and neighborhood predictors of cognitive appraisals of alcohol and use...
April 2017: Journal of Early Adolescence
https://www.readbyqxmd.com/read/28468774/synergy-between-androgen-receptor-antagonism-and-inhibition-of-mtor-and-her2-in-breast-cancer
#9
Michael A Gordon, Nicholas C D'Amato, Haihua Gu, Beatrice Babbs, Julia D Wulfkuhle, Emanuel F Petricoin, Isela Gallagher, Ting Dong, Kathleen Torkko, Bolin Liu, Anthony Elias, Jennifer K Richer
The androgen receptor (AR) is widely expressed in breast cancer (BC) and evidence suggests dependence on AR signaling for growth and survival. AR antagonists such as enzalutamide and seviteronel have shown success in pre-clinical models and clinical trials of prostate cancer, and are currently being evaluated in BC. Reciprocal regulation between AR and the HER2/PI3K/mTOR pathway may contribute to resistance to HER2- and mTOR-targeted therapies; thus, dual inhibition of these pathways may synergistically inhibit BC growth...
May 3, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28462536/is-ethnic-prejudice-declining-in-britain-change-in-social-distance-attitudes-among-ethnic-majority-and-minority-britons
#10
Ingrid Storm, Maria Sobolewska, Robert Ford
Most literature on racial prejudice deals with the racial attitudes of the ethnic majority and ethnic minorities separately. This paper breaks this tradition. We examine the social distance attitudes of white and non-white British residents to test if these attitudes follow the same trends over time, whether they are driven by the same social processes and whether they are inter-related. We have three main findings. Firstly, social distance from other ethnic groups has declined over time for both white and ethnic minority Britons...
April 29, 2017: British Journal of Sociology
https://www.readbyqxmd.com/read/28460001/the-atp-dependent-chromatin-remodeler-chd1-is-recruited-by-transcription-elongation-factors-and-maintains-h3k4me3-h3k36me3-domains-at-actively-transcribed-and-spliced-genes
#11
Yaelim Lee, Daechan Park, Vishwanath R Iyer
Chd1 (Chromodomain Helicase DNA Binding Protein 1) is a conserved ATP-dependent chromatin remodeler that maintains the nucleosomal structure of chromatin, but the determinants of its specificity and its impact on gene expression are not well defined. To identify the determinants of Chd1 binding specificity in the yeast genome, we investigated Chd1 occupancy in mutants of several candidate factors. We found that several components of the PAF1 transcription elongation complex contribute to Chd1 recruitment to highly transcribed genes and identified Spt4 as a factor that appears to negatively modulate Chd1 binding to chromatin...
April 29, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28454842/inactivation-of-planktonic-escherichia-coli-by-focused-2-mhz-ultrasound
#12
Andrew A Brayman, Brian E MacConaghy, Yak-Nam Wang, Keith T Chan, Wayne L Monsky, Anna J McClenny, Thomas J Matula
This study was motivated by the desire to develop a non-invasive means to treat abscesses, and represents the first steps toward that goal. Non-thermal, high-intensity focused ultrasound (HIFU) was used to inactivate Escherichia coli (∼1 × 10(9) cells/mL) in suspension. Cells were treated in 96-well culture plate wells using 1.95-MHz ultrasound and incident focal acoustic pressures as high as 16 MPa peak positive and 9.9 MPa peak negative (free field measurements). The surviving fraction was assessed by coliform culture and the alamarBlue assay...
April 25, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28451889/chronic-pain-predicting-reciprocity-of-support-among-vulnerable-predominantly-african-american-persons-living-with-hiv-aids
#13
Mary M Mitchell, Sarina R Isenberg, Allysha C Maragh-Bass, Amy R Knowlton
Among persons living with HIV/AIDS (PLHIV), approximately two-thirds report moderate to severe pain. Chronic pain can negatively affect PLHIVs' health behaviors and outcomes by interfering with their reciprocity (mutual exchange) of support in their caregiving relationships, which has been found to be associated with PLHIVs' antiretroviral adherence and viral suppression. Data were longitudinal (baseline, 6- and 12-month follow-up) from 383 PLHIV who were formerly or currently using drugs. Utilizing a longitudinal lagged fixed effects structural equation model, we found that never having pain in the past 6 months was predictive of increased reciprocity of support...
April 27, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28450977/empathy-in-negative-and-positive-interpersonal-interactions-what-is-the-relationship-between-central-eeg-fnirs-and-peripheral-autonomic-neurophysiological-responses
#14
Michela Balconi, Maria Elide Maria Elide Vanutelli
Emotional empathy is crucial to understand how we respond to interpersonal positive or negative situations. In the present research, we aim at identifying the neural networks and the autonomic responsiveness underlying the human ability to perceive and empathize with others' emotions when positive (cooperative) or negative (uncooperative) interactions are observed. A multimethodological approach was adopted to elucidate the reciprocal interplay of autonomic (peripheral) and central (cortical) activities in empathic behavior...
2017: Advances in Cognitive Psychology
https://www.readbyqxmd.com/read/28450845/using-exponential-random-graph-models-to-analyze-the-character-of-peer-relationship-networks-and-their-effects-on-the-subjective-well-being-of-adolescents
#15
Can Jiao, Ting Wang, Jianxin Liu, Huanjie Wu, Fang Cui, Xiaozhe Peng
The influences of peer relationships on adolescent subjective well-being were investigated within the framework of social network analysis, using exponential random graph models as a methodological tool. The participants in the study were 1,279 students (678 boys and 601 girls) from nine junior middle schools in Shenzhen, China. The initial stage of the research used a peer nomination questionnaire and a subjective well-being scale (used in previous studies) to collect data on the peer relationship networks and the subjective well-being of the students...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28447814/undetected-scars-self-criticism-attachment-and-romantic-relationships-among-otherwise-well-functioning-childhood-sexual-abuse-survivors
#16
Dana Lassri, Patrick Luyten, Peter Fonagy, Golan Shahar
BACKGROUND: Studies have consistently demonstrated the negative impact of childhood sexual abuse (CSA) on intimate relationships. The majority of studies have focused on revictimization in at-risk or clinical samples, with very few addressing the impact of CSA on otherwise well-functioning adults and even fewer investigating the psychological mechanisms involved. To fill this gap, this study focuses on the effect of CSA on "normative" (nonviolent) romantic relationships in otherwise well-functioning young women, and the mediating role of personality dimension self-criticism and attachment in this regard...
April 27, 2017: Psychological Trauma: Theory, Research, Practice and Policy
https://www.readbyqxmd.com/read/28447372/rapid-thermal-adaptation-in-photosymbionts-of-reef-building-corals
#17
Leela J Chakravarti, Victor H Beltran, Madeleine J H van Oppen
Climate warming is occurring at a rate not experienced by life on Earth for 10 s of millions of years, and it is unknown whether the coral-dinoflagellate (Symbiodinium spp.) symbiosis can evolve fast enough to ensure coral reef persistence. Coral thermal tolerance is partly dependent on the Symbiodinium hosted. Therefore, directed laboratory evolution in Symbiodinium has been proposed as a strategy to enhance coral holobiont thermal tolerance. Using a reciprocal transplant design, we show that the upper temperature tolerance and temperature tolerance range of Symbiodinium C1 increased after ~80 asexual generations (2...
April 27, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28444781/constructing-longitudinal-disease-progression-curves-using-sparse-short-term-individual-data-with-an-application-to-alzheimer-s-disease
#18
C A Budgeon, K Murray, B A Turlach, S Baker, V L Villemagne, S C Burnham
In epidemiology, cohort studies utilised to monitor and assess disease status and progression often result in short-term and sparse follow-up data. Thus, gaining an understanding of the full-term disease pathogenesis can be difficult, requiring shorter-term data from many individuals to be collated. We investigate and evaluate methods to construct and quantify the underlying long-term longitudinal trajectories for disease markers using short-term follow-up data, specifically applied to Alzheimer's disease. We generate individuals' follow-up data to investigate approaches to this problem adopting a four-step modelling approach that (i) determines individual slopes and anchor points for their short-term trajectory, (ii) fits polynomials to these slopes and anchor points, (iii) integrates the reciprocated polynomials and (iv) inverts the resulting curve providing an estimate of the underlying longitudinal trajectory...
April 25, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28442117/tuberculosis-toxoplasmosis-co-infection-in-egyptian-patients-a-reciprocal-impact
#19
Mervat Mashaly, Nairmen Nabih, Iman M Fawzy, Abeer A El Henawy
OBJECTIVE: To assess the concurrent toxoplasmosis infection in Egyptian TB patients and the impact of each infection on the other in terms of increased severity of TB or reactivation of latent Toxoplasma infection. METHODS: Three hundred suspected pulmonary TB cases were initially screened for TB using direct Ziehl Neelsen staining and Lowenstein Jensen culture of their sputa. Rifampicin resistance was detected by Xpert MTB/RIF assay. Control group of 30 age and sex-matched healthy individuals negative for TB was included for comparison...
March 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28439888/emotional-feeding-and-emotional-eating-reciprocal-processes-and-the-influence-of-negative-affectivity
#20
Silje Steinsbekk, Edward D Barker, Clare Llewellyn, Alison Fildes, Lars Wichstrøm
Emotional eating, that is, eating more in response to negative mood, is often seen in children. But the origins of emotional eating remain unclear. In a representative community sample of Norwegian 4-year-olds followed up at ages 6, 8, and 10 years (analysis sample: n = 801), one potential developmental pathway was examined: a reciprocal relation between parental emotional feeding and child emotional eating. The results revealed that higher levels of emotional feeding predicted higher levels of emotional eating and vice versa, adjusting for body mass index and initial levels of feeding and eating...
April 25, 2017: Child Development
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