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Positive reciprocity

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https://www.readbyqxmd.com/read/28938016/a-feed-forward-regulation-of-endothelin-receptors-by-c-jun-in-human-non-pigmented-ciliary-epithelial-cells-and-retinal-ganglion-cells
#1
Junming Wang, Hai-Ying Ma, Raghu R Krishnamoorthy, Thomas Yorio, Shaoqing He
c-Jun, c-Jun N-terminal kinase(JNK) and endothelin B (ETB) receptor have been shown to contribute to the pathogenesis of glaucoma. Previously, we reported that an increase of c-Jun and CCAAT/enhancer binding protein β (C/EBPβ) immunohistostaining is associated with upregulation of the ETB receptor within the ganglion cell layer of rats with elevated intraocular pressure (IOP). In addition, both transcription factors regulate the expression of the ETB receptor in human non-pigmented ciliary epithelial cells (HNPE)...
2017: PloS One
https://www.readbyqxmd.com/read/28937996/sirt1-is-a-positive-regulator-of-in-vivo-bone-mass-and-a-therapeutic-target-for-osteoporosis
#2
Kayvan Zainabadi, Cassie J Liu, Alison L M Caldwell, Leonard Guarente
Overexpression or pharmacological activation of SIRT1 has been shown to extend the lifespan of mice and protect against aging-related diseases. Here we show that pharmacological activation of SIRT1 protects in two models of osteoporosis. Ovariectomized female mice and aged male mice, models for post-menopausal and aging-related osteoporosis, respectively, show significant improvements in bone mass upon treatment with SIRT1 agonist, SRT1720. Further, we find that calorie restriction (CR) results in a two-fold upregulation of sirt1 mRNA expression in bone tissue that is associated with increased bone mass in CR mice...
2017: PloS One
https://www.readbyqxmd.com/read/28935467/reciprocal-role-of-sirt6-and-hexokinase-2-in-the-regulation-of-autophagy-driven-monocyte-differentiation
#3
Ankita Singh, Ellora Sen
Emerging evidences suggest the impact of autophagy on differentiation but the underlying molecular links between metabolic restructuring and autophagy during monocyte differentiation remain elusive. An increase in PPARγ, HK2 and SIRT6 expression was observed upon PMA induced monocyte differentiation. While PPARγ positively regulated HK2 and SIRT6 expression, the latter served as a negative regulator of HK2. Changes in expression of these metabolic modelers were accompanied by decreased glucose uptake and increase in Chibby, a potent antagonist of β-catenin/Wnt pathway...
September 18, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28934847/participation-of-ccl1-in-snail-positive-fibroblasts-in-colorectal-cancer-contribute-to-5-fluorouracil-paclitaxel-chemoresistance
#4
Ziqian Li, Kaying Chan, Yifei Qi, Linlin Lu, Fen Ning, Mengling Wu, Yuan Wang, Shaohui Cai, Jun Du
Purpose: Cancer-associated fibroblasts (CAFs) activated by cancer cells has a central role in development and malignant biological behavior in colorectal cancer (CRC). Adult fibroblasts do not express Snail, but Snail-positive fibroblasts are discovered in the stroma of malignant CRC and reported to be the key role to chemoresistance. However, the reciprocal effect of CAFs expressed Snail to chemoresistance on CRC cells and the underlying molecular mechanisms are not fully characterized...
September 18, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28933645/rar%C3%AE-and-rar%C3%AE-reciprocally-control-k5-progenitor-cell-expansion-in-developing-salivary-glands
#5
Kara A DeSantis, Adam R Stabell, Danielle C Spitzer, Kevin J O'Keefe, Deirdre A Nelson, Melinda Larsen
Understanding the mechanisms of controlled expansion and differentiation of basal progenitor cell populations during organogenesis is essential for developing targeted regenerative therapies. Since the cytokeratin 5-positive (K5(+)) basal epithelial cell population in the salivary gland is regulated by retinoic acid signaling, we interrogated how isoform-specific retinoic acid receptor (RAR) signaling impacts the K5(+) cell population during salivary gland organogenesis to identify RAR isoform-specific mechanisms that could be exploited in future regenerative therapies...
September 21, 2017: Organogenesis
https://www.readbyqxmd.com/read/28925864/kinetic-characterization-of-anticarsia-gemmatalis-digestive-serine-proteases-and-the-inhibitory-effect-of-synthetic-peptides
#6
Adriana Patarroyo Vargas, Yaremis Meriño Cabrera, José Cola Zanuncio, Francelina Rocha, Wellington Garcia Campos, Maria Goreti de Almeida Oliveira
The kinetics of Anticarsia gemmatalis Hübner gut serine proteases with tripeptidyl substrates, and the enzymatic inhibition model using synthetic peptides Gor 3, Gor 4, and Gor 5 are described. The enzymes were purified on p-aminobenzamidine agarose affinity column in an FPLC system using electrophoresis with 12.5% polyacrylamide gel. Michaelis-Menten constants and the inhibition model were determined according to the Dixon methodology and Lineweaver-Burk's double reciprocal. The KM values and catalytic constants of peptide substrates show that A...
September 17, 2017: Protein and Peptide Letters
https://www.readbyqxmd.com/read/28925103/autoimmune-diseases-involving-skin-and-intestinal-mucosa-are-more-frequent-in-adolescents-and-young-adults-suffering-from-atopic-dermatitis
#7
REVIEW
Francesca Cipriani, Alice Marzatico, Giampaolo Ricci
Evidence has emerged about the relationship between atopic dermatitis (AD) and autoimmune diseases, but the underlying mechanism of this association is complex and still unclear. Recent epidemiological data from the published work suggest a positive correlation. The aim of this review is to analyze the frequency of co-occurrence of AD and autoimmune diseases. Our systematic review included 22 articles from PubMed describing the reciprocal association between AD and autoimmune diseases. Although not all the studies achieved statistically significant results, patients suffering from autoimmune diseases involving skin and intestinal mucosa, such as vitiligo, alopecia areata, celiac disease and inflammatory bowel diseases, showed a higher risk to have AD as comorbidity...
September 19, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28919998/reciprocal-influence-of-b-cells-and-tumor-macro-and-microenvironments-in-the-apc-min-model-of-colorectal-cancer
#8
Francesca Mion, Stefania Vetrano, Silvia Tonon, Viviana Valeri, Andrea Piontini, Alessia Burocchi, Luciana Petti, Barbara Frossi, Alessandro Gulino, Claudio Tripodo, Mario P Colombo, Carlo E Pucillo
One of the most fascinating aspects of the immune system is its dynamism, meant as the ability to change and readapt according to the organism needs. Following an insult, we assist to the spontaneous organization of different immune cells which cooperate, locally and at distance, to build up an appropriate response. Throughout tumor progression, adaptations within the systemic tumor environment, or macroenvironment, result in the promotion of tumor growth, tumor invasion and metastasis to distal organs, but also to dramatic changes in the activity and composition of the immune system...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28913669/resolving-distinct-molecular-origins-for-copper-effects-on-pai-1
#9
Joel C Bucci, Carlee S McClintock, Yuzhuo Chu, Gregory L Ware, Kayla D McConnell, Joseph P Emerson, Cynthia B Peterson
Components of the fibrinolytic system are subjected to stringent control to maintain proper hemostasis. Central to this regulation is the serpin plasminogen activator inhibitor-1 (PAI-1), which is responsible for specific and rapid inhibition of fibrinolytic proteases. Active PAI-1 is inherently unstable and readily converts to a latent, inactive form. The binding of vitronectin and other ligands influences stability of active PAI-1. Our laboratory recently observed reciprocal effects on the stability of active PAI-1 in the presence of transition metals, such as copper, depending on the whether vitronectin was also present (Thompson et al...
September 14, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28903715/reciprocal-influences-between-loneliness-and-self-centeredness-a-cross-lagged-panel-analysis-in-a-population-based-sample-of-african-american-hispanic-and-caucasian-adults
#10
John T Cacioppo, Hsi Yuan Chen, Stephanie Cacioppo
Loneliness has been posited to increase the motivation to repair or replace deficient social relationships and, seemingly paradoxically, to increase the implicit motivation for self-preservation. In the current research, we report a cross-lagged panel analysis of 10 waves of longitudinal data ( N = 229) on loneliness and self-centeredness (as gauged by Feeney and Collins's measure of chronic self-focus) in a representative sample of middle-aged and older adults. As predicted by the proposition that loneliness increases the implicit motivation for self-preservation, loneliness in the current year predicts self-centeredness in the subsequent year beyond what is explained by current-year demographic variables, self-centeredness, depressive symptomatology, and overall negative mood...
August 2017: Personality & Social Psychology Bulletin
https://www.readbyqxmd.com/read/28903711/authoritarianism-and-national-identity-examining-the-longitudinal-effects-of-sdo-and-rwa-on-nationalism-and-patriotism
#11
Danny Osborne, Petar Milojev, Chris G Sibley
The resurgence of right-wing political parties across the globe raises questions about the origins of national identity. Based on the Dual Process Model of Ideology and Prejudice, we argue that people's tendency to submit to ingroup authorities (Right-Wing Authoritarianism [RWA]) and preference for group-based hierarchy (Social Dominance Orientation [SDO]) underlie people's belief in the superiority of their nation (nationalism) and attachment to their homeland (patriotism). We examine these hypotheses using three waves of data from an annually conducted national longitudinal panel study of New Zealanders ( N = 3,838)...
August 2017: Personality & Social Psychology Bulletin
https://www.readbyqxmd.com/read/28901904/chryseomicrobium-deserti-sp-nov-isolated-from-desert-soil-in-south-korea
#12
Pei Lin, Zheng-Fei Yan, Chang-Tian Li, MooChang Kook, Qi-Jun Wang, Tae-Hoo Yi
A Gram-stain positive, aerobic, non-motile, rod-shaped bacterium (THG-T1.18T) was isolated from desert soil. Growth occurred at 20-35 °C (optimum 28-30 °C), at pH 5-7 (optimum 7) and at 0-4 % NaCl (optimum 0-1 %). Based on 16S rRNA sequence analysis, the nearest phylogenetic neighbours of strain THG-T1.18T were identified as Chryseomicrobium amylolyticum DSM 23442T (96.6 %), Chryseomicrobium imtechense JCM 16573T (96.3 %) and Chryseomicrobium aureum KACC 17219T (96.1 %). The polar lipids were diphosphatidylglycerol, phosphatidylethanolamine, phosphatidylglycerol, two unidentified aminolipids and one unidentified glycolipid...
September 13, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28900837/perseverative-cognition-as-an-explanatory-mechanism-in-the-relation-between-job-demands-and-sleep-quality
#13
Michelle Van Laethem, Debby G J Beckers, Sabine A E Geurts, Johanna Garefelt, Linda L Magnusson Hanson, Constanze Leineweber
PURPOSE: The aim of this longitudinal three-wave study was to examine (i) reciprocal associations among job demands, work-related perseverative cognition (PC), and sleep quality; (ii) PC as a mediator in-between job demands and sleep quality; and (iii) continuous high job demands in relation to sleep quality and work-related PC over time. METHOD: A representative sample of the Swedish working population was approached in 2010, 2012, and 2014, and 2316 respondents were included in this longitudinal full-panel survey study...
September 12, 2017: International Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/28891509/role-of-the-medullary-lateral-tegmental-field-in-sympathetic-control
#14
Michael George Zaki Ghali
The sympathetic nervous system maintains and regulates arterial pressure and tissue perfusion, via control of cardiac output and vasomotor tone. Sympatho-vascular-mediated increases in blood pressure are effected by arterioloconstriction, which causes an increase in afterload, and/or venoconstriction, which increases venous return, left ventricular preload, and consequently, the force of cardiac contraction via Frank-Starling mechanisms; withdrawal of sympathetic drive elicits reciprocal effects. Spinalization reduces mammalian arterial pressure to 40-50 mm Hg consequent to the elimination of descending medullary pre-sympathetic bulbospinal drive to preganglionic sympathetic fibers in the intermediolateral cell column of the spinal cord...
2017: Journal of Integrative Neuroscience
https://www.readbyqxmd.com/read/28886127/genome-wide-mirna-response-to-anacardic-acid-in-breast-cancer-cells
#15
David J Schultz, Penn Muluhngwi, Negin Alizadeh-Rad, Madelyn A Green, Eric C Rouchka, Sabine J Waigel, Carolyn M Klinge
MicroRNAs are biomarkers and potential therapeutic targets for breast cancer. Anacardic acid (AnAc) is a dietary phenolic lipid that inhibits both MCF-7 estrogen receptor α (ERα) positive and MDA-MB-231 triple negative breast cancer (TNBC) cell proliferation with IC50s of 13.5 and 35 μM, respectively. To identify potential mediators of AnAc action in breast cancer, we profiled the genome-wide microRNA transcriptome (microRNAome) in these two cell lines altered by the AnAc 24:1n5 congener. Whole genome expression profiling (RNA-seq) and subsequent network analysis in MetaCore Gene Ontology (GO) algorithm was used to characterize the biological pathways altered by AnAc...
2017: PloS One
https://www.readbyqxmd.com/read/28886010/mobility-can-promote-the-evolution-of-cooperation-via-emergent-self-assortment-dynamics
#16
Jaideep Joshi, Iain D Couzin, Simon A Levin, Vishwesha Guttal
The evolution of costly cooperation, where cooperators pay a personal cost to benefit others, requires that cooperators interact more frequently with other cooperators. This condition, called positive assortment, is known to occur in spatially-structured viscous populations, where individuals typically have low mobility and limited dispersal. However many social organisms across taxa, from cells and bacteria, to birds, fish and ungulates, are mobile, and live in populations with considerable inter-group mixing...
September 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28875331/implication-of-connexin30-on-the-stemness-of-glioma-connexin30-reverses-the-malignant-phenotype-of-glioma-by-modulating-igf-1r-cd133-and-cmyc
#17
Sankaradoss Arun, Shantha Ravisankar, Arambakkam Janardhanam Vanisree
Gap-junctional intercellular communication (GJIC) plays a major role in the malignant growth of glioma. Although the mechanistic aspects of GJIC have been extensively studied, the role of connexins in the regulation of the malignant behavior of glioma stem cells (GSCs) remains unclear. In our previous studies, we have shown that connexin30 can interfere with the insulin-like growth factor 1 receptor (IGF-1R), which is known for self-renewal and pluripotency. Following our earlier in vitro observation, in this work, we aimed to study the consequence of this influence of Cx30 on IGF-1R by evaluating the marker of GSCs, CD133 and oncoprotein, cMyc...
September 5, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28872301/the-undecaprenyl-phosphate-phosphatase-activity-of-undecaprenol-kinase-regulates-the-lipid-pool-in-gram-positive-bacteria
#18
Lin-Ya Huang, Shih-Chi Wang, Ting-Jen R Cheng, Chi-Huey Wong
Bacteria cell walls contain many repeating glycan structures, such as peptidoglycans, lipopolysaccharides, teichoic acids and capsular polysaccharides. Their synthesis starts in the cytosol, and they are constructed from a glycan lipid carrier, undecaprenyl phosphate (C55P), which is essential for cell growth and survival. The lipid derivative undecaprenol (C55OH) is predominant in many Gram-positive bacteria but has not been detected in Gram-negative bacteria; its origin and role have thus remained unknown...
September 5, 2017: Biochemistry
https://www.readbyqxmd.com/read/28865506/-anaerobic-bacteria-with-clinical-relevance-morphologic-and-taxonomic-classification-distribution-among-human-microbiota-and-microbiologic-diagnosis
#19
João Alves, Susana Peres, Elsa Gonçalves, Kamal Mansinho
The wide burden of anaerobic bacteria colonizing human body comprises about 90% of its total biomass. The biotic relationship between humans and its microbiota sets reciprocal benefits, albeit with pathogenic potencial for the human being in particular dysbiosis situations. Infections adjacent to or originating from the skin or mucous membranes of the intestinal, genitourinary and upper respiratory tracts are often polymicrobial in nature, whereby should anaerobes be invariably included in the etiological differential diagnosis of these conditions...
May 31, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28861396/the-role-of-ompr-in-the-expression-of-genes-of-the-kdgr-regulon-involved-in-the-uptake-and-depolymerization-of-oligogalacturonides-in-yersinia-enterocolitica
#20
Marta Nieckarz, Adrianna Raczkowska, Karolina Jaworska, Ewa Stefańska, Karolina Skorek, Dorota Stosio, Katarzyna Brzostek
Oligogalacturonide (OGA)-specific porins of the KdgM family have previously been identified and characterized in enterobacterial plant pathogens. We found that deletion of the gene encoding response regulator OmpR causes the porin KdgM2 to become one of the most abundant proteins in the outer membrane of the human enteropathogen Yersinia enterocolitica. Reporter gene fusion and real-time PCR analysis confirmed that the expression of kdgM2 is repressed by OmpR. We also found that kdgM2 expression is subject to negative regulation by KdgR, a specific repressor of genes involved in the uptake and metabolism of pectin derivatives in plant pathogens...
2017: Frontiers in Cellular and Infection Microbiology
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