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https://www.readbyqxmd.com/read/28208577/single-nucleotide-polymorphism-of-ppar%C3%AE-a-protein-at-the-crossroads-of-physiological-and-pathological-processes
#1
Maria Petrosino, Laura Lori, Alessandra Pasquo, Clorinda Lori, Valerio Consalvi, Velia Minicozzi, Silvia Morante, Antonio Laghezza, Alessandra Giorgi, Davide Capelli, Roberta Chiaraluce
Genome polymorphisms are responsible for phenotypic differences between humans and for individual susceptibility to genetic diseases and therapeutic responses. Non-synonymous single-nucleotide polymorphisms (nsSNPs) lead to protein variants with a change in the amino acid sequence that may affect the structure and/or function of the protein and may be utilized as efficient structural and functional markers of association to complex diseases. This study is focused on nsSNP variants of the ligand binding domain of PPARγ a nuclear receptor in the superfamily of ligand inducible transcription factors that play an important role in regulating lipid metabolism and in several processes ranging from cellular differentiation and development to carcinogenesis...
February 10, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28202649/antioxidants-and-embryo-phenotype-is-there-experimental-evidence-for-strong-integration-of-the-antioxidant-system
#2
Cristina Daniela Possenti, Filiz Karadas, Graziano Colombo, Manuela Caprioli, Diego Rubolini, Aldo Milzani, Isabella Dalle Donne, Nicola Saino, Marco Parolini
Organisms have evolved complex defense systems against oxidative stress. Bird eggs contain maternally derived antioxidants that protect embryos from oxidative damage. The antioxidant system components are thought to be integrated, but few studies have analyzed the covariation between antioxidant concentrations, embryo 'oxidative status' and morphology. In addition, no study has tested the effects of experimental change in yolk antioxidant concentration on other antioxidants, on their reciprocal relationships and on their relationships with embryo oxidative status or growth, which are expected if antioxidants defenses are integrated...
February 15, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28198099/the-role-of-trust-in-centeringpregnancy-building-interpersonal-trust-relationships-in-group-based-prenatal-care-in-the-netherlands
#3
Liselotte Kweekel, Trudie Gerrits, Marlies Rijnders, Patrick Brown
BACKGROUND: CenteringPregnancy (CP) is a specific model of group-based prenatal care for women, implemented in 44 midwifery practices in The Netherlands since 2011. Women have evaluated CP positively, especially in terms of social support, and improvements have been made in birthweight and preterm-birth outcomes; however, there is limited understanding as to why. The purpose of this study was to examine the mechanisms that create trusting relationships within CP to better understand CP outcomes and effectiveness...
March 2017: Birth
https://www.readbyqxmd.com/read/28193222/phosphorylation-dependent-regulation-of-aldh1a1-by-aurora-kinase-a-insights-on-their-synergistic-relationship-in-pancreatic-cancer
#4
Jing Wang, Kumar Nikhil, Keith Viccaro, Lei Chang, Jacoba White, Kavita Shah
BACKGROUND: Epithelial-to-mesenchymal transition (EMT) and cancer stem cell (CSC) formation are key underlying causes that promote extensive metastasis, drug resistance, and tumor recurrence in highly lethal pancreatic cancer. The mechanisms leading to EMT and CSC phenotypes are not fully understood, which has hindered the development of effective targeted therapies capable of improving treatment outcomes in patients with pancreatic cancer. RESULTS: We show a central role of Aurora kinase A (AURKA) in promoting EMT and CSC phenotypes via ALDH1A1, which was discovered as its direct substrate using an innovative chemical genetic screen...
February 13, 2017: BMC Biology
https://www.readbyqxmd.com/read/28188584/bidirectional-temporal-associations-of-sleep-with-positive-events-affect-and-stressors-in-daily-life-across-a-week
#5
Nancy L Sin, David M Almeida, Tori L Crain, Ellen Ernst Kossek, Lisa F Berkman, Orfeu M Buxton
BACKGROUND: Sleep is intricately tied to emotional well-being, yet little is known about the reciprocal links between sleep and psychosocial experiences in the context of daily life. PURPOSE: The aim of this study is to evaluate daily psychosocial experiences (positive and negative affect, positive events, and stressors) as predictors of same-night sleep quality and duration, in addition to the reversed associations of nightly sleep predicting next-day experiences...
February 10, 2017: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/28184029/feedback-circuitry-via-let-7c-between-lncrna-ccat1-and-c-myc-is-involved-in-cigarette-smoke-extract-induced-malignant-transformation-of-hbe-cells
#6
Lu Lu, Hong Qi, Fei Luo, Hui Xu, Min Ling, Yu Qin, Ping Yang, Xinlu Liu, Qianlei Yang, Junchao Xue, Chao Chen, Jiachun Lu, Quanyong Xiang, Qizhan Liu, Qian Bian
Cigarette smoking is a primary risk factor for the development of lung cancer, which is regarded as the leading cause of cancer-related deaths. The process of malignant transformation of cells, however, is complex and elusive. The present study investigated the roles of an lncRNA, CCAT1, and a transcriptional factor, c-Myc, in human bronchial epithelial (HBE) cell transformation induced by cigarette smoke extract. With acute and chronic treatment of HBE cells, cigarette smoke extract induced increases of CCAT1 and c-Myc levels and decreases of levels of let-7c, a microRNA...
February 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28178207/impact-of-cannabis-use-on-treatment-outcomes-among-adults-receiving-cognitive-behavioral-treatment-for-ptsd-and-substance-use-disorders
#7
Lesia M Ruglass, Alina Shevorykin, Vanja Radoncic, Kathryn M Z Smith, Philip H Smith, Isaac R Galatzer-Levy, Santiago Papini, Denise A Hien
BACKGROUND: Research has demonstrated a strong link between trauma, posttraumatic stress disorder PTSD and substance use disorders (SUDs) in general and cannabis use disorders in particular. Yet, few studies have examined the impact of cannabis use on treatment outcomes for individuals with co-occurring PTSD and SUDs. METHODS: Participants were 136 individuals who received cognitive-behavioral therapies for co-occurring PTSD and SUD. Multivariate regressions were utilized to examine the associations between baseline cannabis use and end-of-treatment outcomes...
February 7, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/28176874/cxcl12-cxcr4-axis-induced-mir-125b-promotes-invasion-and-confers-5-fluorouracil-resistance-through-enhancing-autophagy-in-colorectal-cancer
#8
Xinfeng Yu, Wenna Shi, Yuhang Zhang, Xiaohui Wang, Shiyue Sun, Zhiyu Song, Man Liu, Qiao Zeng, Shuxiang Cui, Xianjun Qu
The activation of CXCL12/CXCR4 axis is associated with potential progression of cancer, such as invasion, metastasis and chemoresistance. However, the underlying mechanisms of CXCL12/CXCR4 axis and cancer progression have been poorly explored. We hypothesized that miRNAs might be critical downstream mediators of CXCL12/CXCR4 axis involved in cancer invasion and chemoresistance in CRC. In human CRC cells, we found that the activation of CXCL12/CXCR4 axis promoted epithelial-mesenchymal transition (EMT) and concurrent upregulation of miR-125b...
February 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28176309/achievement-emotions-and-academic-performance-longitudinal-models-of-reciprocal-effects
#9
Reinhard Pekrun, Stephanie Lichtenfeld, Herbert W Marsh, Kou Murayama, Thomas Goetz
A reciprocal effects model linking emotion and achievement over time is proposed. The model was tested using five annual waves of the Project for the Analysis of Learning and Achievement in Mathematics (PALMA) longitudinal study, which investigated adolescents' development in mathematics (Grades 5-9; N = 3,425 German students; mean starting age = 11.7 years; representative sample). Structural equation modeling showed that positive emotions (enjoyment, pride) positively predicted subsequent achievement (math end-of-the-year grades and test scores), and that achievement positively predicted these emotions, controlling for students' gender, intelligence, and family socioeconomic status...
February 8, 2017: Child Development
https://www.readbyqxmd.com/read/28174586/maternal-effects-on-seed-and-seedling-phenotypes-in-reciprocal-f-1-hybrids-of-the-common-bean-phaseolus-vulgaris-l
#10
Jugpreet Singh, Jose A Clavijo Michelangeli, Salvador A Gezan, Hyungwon Lee, C Eduardo Vallejos
Maternal control of seed size in the common bean provides an opportunity to study genotype-independent seed weight effects on early seedling growth and development. We set out to test the hypothesis that the early heterotrophic growth of bean seedlings is determined by both the relative amount of cotyledon storage reserves and the genotype of the seedling, provided the hybrid genotype could be fully expressed in the seedlings. The hypothesis was tested via comparison of seed weight and seedling growth phenotypes of small-seeded (wild, ~0...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28171750/crosstalk-between-clcb-dyn1-mediated-adaptive-clathrin-mediated-endocytosis-and-epidermal-growth-factor-receptor-signaling-increases-metastasis
#11
Ping-Hung Chen, Nawal Bendris, Yi-Jing Hsiao, Carlos R Reis, Marcel Mettlen, Hsuan-Yu Chen, Sung-Liang Yu, Sandra L Schmid
Signaling receptors are internalized and regulated by clathrin-mediated endocytosis (CME). Two clathrin light chain isoforms, CLCa and CLCb, are integral components of the endocytic machinery whose differential functions remain unknown. We report that CLCb is specifically upregulated in non-small-cell lung cancer (NSCLC) cells and is associated with poor patient prognosis. Engineered single CLCb-expressing NSCLC cells, as well as "switched" cells that predominantly express CLCb, exhibit increased rates of CME and altered clathrin-coated pit dynamics...
February 6, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28169569/physical-activity-and-motor-competence-present-a-positive-reciprocal-longitudinal-relationship-across-childhood-and-early-adolescence
#12
Rodrigo A Lima, Karin Pfeiffer, Lisbeth R Larsen, Anna Bugge, Niels C Moller, Lars B Anderson, David F Stodden
BACKGROUND: The current study evaluated the reciprocal longitudinal relationship between physical activity (PA) and motor competence (MC) and the potential mediation of cardiorespiratory endurance across seven years. METHODS: This was a seven-year longitudinal study with three measuring points (mean ages [in years] and respective sample size: 6.75 ±0.37, n=696; 9.59 ±1.07, n=617; 13.35 ±0.34, n=513) - the Copenhagen School Child Intervention Study (CoSCIS). PA was assessed using accelerometers...
February 7, 2017: Journal of Physical Activity & Health
https://www.readbyqxmd.com/read/28167297/loss-of-pin1-suppresses-hedgehog-driven-medulloblastoma-tumorigenesis
#13
Tao Xu, Honglai Zhang, Sung-Soo Park, Sriram Venneti, Rork Kuick, Kimberly Ha, Lowell Evan Michael, Mariarita Santi, Chiyoko Uchida, Takafumi Uchida, Ashok Srinivasan, James M Olson, Andrzej A Dlugosz, Sandra Camelo-Piragua, Jean-François Rual
Medulloblastoma is the most common malignant brain tumor in children. Therapeutic approaches to medulloblastoma (combination of surgery, radiotherapy, and chemotherapy) have led to significant improvements, but these are achieved at a high cost to quality of life. Alternative therapeutic approaches are needed. Genetic mutations leading to the activation of the Hedgehog pathway drive tumorigenesis in ~30% of medulloblastoma. In a yeast two-hybrid proteomic screen, we discovered a novel interaction between GLI1, a key transcription factor for the mediation of Hedgehog signals, and PIN1, a peptidylprolyl cis/trans isomerase that regulates the postphosphorylation fate of its targets...
February 3, 2017: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/28166469/promoting-translational-research-among-movement-science-occupational-science-and-occupational-therapy
#14
Robert L Sainburg, Sook-Lei Liew, Scott H Frey, Florence Clark
Integration of research in the fields of neural control of movement and biomechanics (collectively referred to as movement science) with the field of human occupation directly benefits both areas of study. Specifically, incorporating many of the quantitative scientific methods and analyses employed in movement science can help accelerate the development of rehabilitation-relevant research in occupational therapy (OT) and occupational science (OS). Reciprocally, OT and OS, which focus on the performance of everyday activities (occupations) to promote health and well-being, provide theoretical frameworks to guide research on the performance of actions in the context of social, psychological, and environmental factors...
February 6, 2017: Journal of Motor Behavior
https://www.readbyqxmd.com/read/28163867/umbilical-cord-blood-androgen-levels-and-asd-related-phenotypes-at-12-and-36%C3%A2-months-in-an-enriched-risk-cohort-study
#15
Bo Y Park, Brian K Lee, Igor Burstyn, Loni P Tabb, Jeff A Keelan, Andrew J O Whitehouse, Lisa A Croen, Margaret D Fallin, Irva Hertz-Picciotto, Owen Montgomery, Craig J Newschaffer
BACKGROUND: Autism spectrum disorder (ASD) affects more than 1% of children in the USA. The male-to-female prevalence ratio of roughly 4:1 in ASD is a well-recognized but poorly understood phenomenon. An explicit focus on potential etiologic pathways consistent with this sex difference, such as those involving prenatal androgen exposure, may help elucidate causes of ASD. Furthermore, the multi-threshold liability model suggests that the genetic mechanisms in females with ASD may be distinct and may modulate ASD risk in families with female ASD in the pedigree...
2017: Molecular Autism
https://www.readbyqxmd.com/read/28161681/the-met80ala-and-tyr67his-met80ala-mutants-of-human-cytochrome-c-shed-light-on-the-reciprocal-role-of-met80-and-tyr67-in-regulating-ligand-access-into-the-heme-pocket
#16
Chiara Ciaccio, Lorenzo Tognaccini, Theo Battista, Manuela Cervelli, Barry D Howes, Roberto Santucci, Massimo Coletta, Paolo Mariottini, Giulietta Smulevich, Laura Fiorucci
The spectroscopic and functional properties of the single Met80Ala and double Tyr67His/Met80Ala mutants of human cytochrome c have been investigated in their ferric and ferrous forms, and in the presence of different ligands, in order to clarify the reciprocal effect of these two residues in regulating the access of exogenous molecules into the heme pocket. In the ferric state, both mutants display an aquo high spin and a low spin species. The latter corresponds to an OH(-) ligand in Met80Ala but to a His in the double mutant...
January 24, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28161631/reciprocal-regulation-of-mir-1254-and-c-myc-in-oral-squamous-cell-carcinoma-suppresses-emt-mediated-metastasis-and-tumor-initiating-properties-through-mapk-signaling
#17
Meng Lu, Wei-Hui Chen, Cheng-Yong Wang, Chuan-Qing Mao, Jin Wang
AIM: This study aimed to determine the effect of miR-1254 on oral squamous cell carcinoma (OSCC) metastasis and the specific mechanism involved. METHODS: The metastatic properties of OSCC cells were analyzed by transwell assays. The tumor-initiating properties of OSCC cells were analyzed by tumor sphere formation assays. The mRNA and protein expressions of targeted genes were determined by quantitative polymerase chain reaction assays and western blot analyses, respectively...
February 1, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28161508/contribution-of-neuroinflammation-and-immunity-to-brain-aging-and-the-mitigating-effects-of-physical-and-cognitive-interventions
#18
REVIEW
Svetlana Di Benedetto, Ludmila Müller, Elisabeth Wenger, Sandra Düzel, Graham Pawelec
It is widely accepted that the brain and the immune system continuously interact during normal as well as pathological functioning. Human aging is commonly accompanied by low-grade inflammation in both the immune and central nervous systems, thought to contribute to many age-related diseases. This review of the current literature focuses first on the normal neuroimmune interactions occurring in the brain, which promote learning, memory and neuroplasticity. Further, we discuss the protective and dynamic role of barriers to neuroimmune interactions, which have become clearer with the recent discovery of the meningeal lymphatic system...
February 1, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28160501/population-genetic-analysis-of-a-parasitic-mycovirus-to-infer-the-invasion-history-of-its-fungal-host
#19
Corine N Schoebel, Leticia Botella, Vaidotas Lygis, Daniel Rigling
Hymenoscyphus fraxineus mitovirus 1 (HfMV1) occurs in the fungus Hymenoscyphus fraxineus, an introduced plant pathogen responsible for the devastating ash dieback epidemic in Europe. Here, we explored the prevalence and genetic structure of HfMV1 in order to elucidate the invasion history of both the virus and the fungal host. A total of 1298 H. fraxineus isolates (181 from Japan and 1117 from Europe) were screened for the presence of this RNA virus and 301 virus-positive isolates subjected to partial sequence analysis of the viral RNA polymerase gene...
February 4, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28151810/are-geographic-differences-in-transplantation-inherently-wrong
#20
Keren Ladin, Douglas W Hanto
PURPOSE OF REVIEW: Geographic variation in liver transplantation has been the subject of extensive scrutiny, reflecting concerns that location is unfairly determinative for people needing organ transplantation. Drawing upon a number of established ethical approaches, we examine whether geographic differences in access to livers are inherently unethical. RECENT FINDINGS: We posit that the ethical imperative for redistribution largely hinges upon the belief that access to organs systematically disadvantages certain identifiable groups of patients over others...
February 1, 2017: Current Opinion in Organ Transplantation
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