keyword
https://read.qxmd.com/read/38477463/improving-diabetic-wound-healing-outcomes-with-topical-growth-factor-therapies-systematic-review-and-network-meta-analysis-of-randomised-controlled-trials
#1
JOURNAL ARTICLE
Andrew Yew Wei Wong, Natalie Ming Foong Hooi, Brian Sheng Yep Yeo, Rehena Sultana, Yong Mong Bee, Ainsley Ryan Yan Bin Lee, Sook Muay Tay
CONTEXT: Diabetes mellitus is associated with morbid complications such as diabetic foot ulcers (DFUs) that may lead to amputations or mortality if not managed adequately. OBJECTIVE: New adjunctive interventions to treat diabetic wounds include topical biologics and growth factors. This study aims to evaluate their efficacy in improving wound healing outcomes and safety. DATA SOURCES: Comprehensive database searches of MEDLINE via PubMed, EMBASE and Cochrane performed from inception to December 2022...
March 13, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38472627/the-implication-of-diabetes-specialized-nurses-in-aiming-for-the-better-treatment-and-management-of-patients-with-diabetes-mellitus-a-brief-narrative-review
#2
REVIEW
Yefang Zhu, Hongmei Zhang, Ying Xi, Hongli Zhu, Yan Lu, Xue Luo, Zhangui Tang, Hong Lei
Diabetes mellitus (DM) is regarded as one of the most critical public health challenges of the 21st century. It has evolved into a burgeoning epidemic since the last century, and today ranks among the major causes of mortality worldwide. Diabetes specialist nurses (DSNs) are central to good patient care and outcomes including confident self-care management. Evidence shows that DSNs are cost-effective, improve clinical outcomes, and reduce length of stay in hospital. In this brief narrative review, we aim to describe the roles of DSNs and their contribution in the treatment and management of patients with DM...
March 12, 2024: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://read.qxmd.com/read/38463193/the-mechanism-of-pyroptosis-and-its-application-prospect-in-diabetic-wound-healing
#3
REVIEW
Abdullah Al Mamun, Chuxiao Shao, Peiwu Geng, Shuanghu Wang, Jian Xiao
Pyroptosis defines a form of pro-inflammatory-dependent programmed cell death triggered by gasdermin proteins, which creates cytoplasmic pores and promotes the activation and accumulation of immune cells by releasing several pro-inflammatory mediators and immunogenic substances upon cell rupture. Pyroptosis comprises canonical (mediated by Caspase-1) and non-canonical (mediated by Caspase-4/5/11) molecular signaling pathways. Numerous studies have explored the contributory roles of inflammasome and pyroptosis in the progression of multiple pathological conditions such as tumors, nerve injury, inflammatory diseases and metabolic disorders...
2024: Journal of Inflammation Research
https://read.qxmd.com/read/38461443/effect-of-a-multidisciplinary-team-approach-in-patients-with-diabetic-foot-ulcers-on-major-adverse-limb-events-males-systematic-review-and-meta-analysis-for-the-development-of-the-italian-guidelines-for-the-treatment-of-diabetic-foot-syndrome
#4
REVIEW
Marco Meloni, Laura Giurato, Luca Monge, Cesare Miranda, Alessia Scatena, Benedetta Ragghianti, Giovanni Antonio Silverii, Cristiana Vermigli, Alessandro De Cassai, Antonio Volpe, Rodolfo Tramonta, Gerardo Medea, Corrado Bordieri, Marco Falcone, Laura Stefanon, Andrea Bernetti, Cristina Cappella, Mauro Gargiulo, Valentina Lorenzoni, Germano Scevola, Eugenio Stabile, Roberto Da Ros, Giuseppe Murdolo, Eleonora Bianchini, Francesco Gaggia, Carlotta Gauna, Francesco Romeo, Matteo Apicella, Michele Mantuano, Matteo Monami, Luigi Uccioli
The treatment of patients with diabetic foot ulcers (DFUs) is extremely complex, requiring a comprehensive approach that involves a variety of different healthcare professionals. Several studies have shown that a multidisciplinary team (MDT) approach is useful to achieve good clinical outcomes, reducing major and minor amputation and increasing the chance of healing. Despite this, the multidisciplinary approach is not always a recognized treatment strategy. The aim of this meta-analysis was to assess the effects of an MDT approach on major adverse limb events, healing, time-to-heal, all-cause mortality, and other clinical outcomes in patients with active DFUs...
March 10, 2024: Acta Diabetologica
https://read.qxmd.com/read/38457306/use-of-hypothermically-stored-amniotic-membrane-on-diabetic-foot-ulcers-a-multicentre-retrospective-case-series
#5
JOURNAL ARTICLE
Anna Sanchez, Alan Hartstein, Hisham Ashry, Maryam Raza
OBJECTIVE: The aim of this retrospective case series was to report on the outcomes of diabetic foot ulcers (DFUs) managed with hypothermically stored amniotic membrane (HSAM). METHOD: Deidentified case data of patients who received HSAM were obtained from wound care sites across the US. Data were collected, beginning at the first patient visit to the wound care site (first presentation), at the visit in which the first HSAM application occurred (baseline), and at each subsequent visit over 12 weeks of treatment (follow-up)...
March 1, 2024: Journal of Wound Care
https://read.qxmd.com/read/38456109/a-review-of-patient-s-knowledge-and-practice-of-diabetic-foot-self-care
#6
REVIEW
Eka Kartika Untari, Tri Murti Andayani, Nanang Munif Yasin, Rizka Humardewayanti Asdie
Since diabetic foot ulcers (DFUs) are common among diabetes patients, it is essential to increase patients' knowledge and self-care practices to ensure early recognition and management and reduce amputation risk. Therefore, the goal of this review was to identify the range and level of knowledge of people with DFUs and the type of self-care they undertake. A literature review was conducted using the electronic databases PubMed and Google scholar with 'diabetic foot', 'self-care', 'practice' and 'behaviour' as searching keywords...
February 2024: Malaysian Journal of Medical Sciences: MJMS
https://read.qxmd.com/read/38449025/tibial-cortex-transverse-transport-promotes-ischemic-diabetic-foot-ulcer-healing-via-enhanced-angiogenesis-and-inflammation-modulation-in-a-novel-rat-model
#7
JOURNAL ARTICLE
Wencong Qin, Kaibin Liu, Hongjie Su, Jun Hou, Shenghui Yang, Kaixiang Pan, Sijie Yang, Jie Liu, Peilin Zhou, Zhanming Lin, Puxiang Zhen, Yongjun Mo, Binguang Fan, Zhenghui Li, Xiaocong Kuang, Xinyu Nie, Qikai Hua
BACKGROUND: Tibial Cortex Transverse Transport (TTT) represents an innovative surgical method for treating lower extremity diabetic foot ulcers (DFUs), yet its underlying mechanisms remain elusive. Establishing an animal model that closely mirrors clinical scenarios is both critical and novel for elucidating the mechanisms of TTT. METHODS: We established a diabetic rat model with induced hindlimb ischemia to mimic the clinical manifestation of DFUs. TTT was applied using an external fixator for regulated bone movement...
March 6, 2024: European Journal of Medical Research
https://read.qxmd.com/read/38447218/the-effect-of-traditional-chinese-medicine-soaking-method-on-the-healing-of-diabetic-foot-ulcers-a-meta-analysis
#8
JOURNAL ARTICLE
Jintao Han, Jiani Shen, Boyue Ling
Foot infections, sores or deep tissue damage from diabetes can be a serious psychological and physical injury. This paper aims at making meta-analyses on the therapeutic effects of traditional Chinese medicine (TCM) on diabetic foot ulcers. The Chinese National Knowledge Infrastructure, VIP Database, Wanfang Database and so on, has conducted a randomized controlled trial to evaluate the clinical effect of TCM soaking method for diabetes patients with diabetes. Literature has been determined to be included by computer search and by hand rough checks...
March 2024: International Wound Journal
https://read.qxmd.com/read/38442901/facilitating-healing-in-diabetic-foot-ulcers-using-homeopathy-in-a-multi-disciplinary-integrative-approach-two-evidence-based-case-reports
#9
JOURNAL ARTICLE
Hima Bindu Ponnam
BACKGROUND:  A rising incidence of diabetic foot ulcers (DFUs) in India has escalated the rate of lower limb amputations in the country. The present study aims to evaluate the potential healing properties of homeopathic medicines as a part of the integrative management of DFUs through two evidence-based case reports. METHODS:  Two patients with DFUs, identified as Wagner grade 2, having had diabetes for 12 years, were treated with individualized homeopathic medicine within a multi-disciplinary approach...
March 5, 2024: Homeopathy: the Journal of the Faculty of Homeopathy
https://read.qxmd.com/read/38439010/prevalence-and-risk-factors-for-diabetic-foot-complications-among-people-living-with-diabetes-in-harare-zimbabwe-a-cross-sectional-study
#10
JOURNAL ARTICLE
Oppah Kuguyo, Doreen Macherera Mukona, Vasco Chikwasha, Lovemore Gwanzura, Joconiah Chirenda, Alice Matimba
BACKGROUND: Diabetic foot disease (DF) is a common diabetes-related complication; however, the prevalence and associated risk factors for DF are not well characterised among people living with diabetes (PLWD) in Zimbabwe. This may suggest the unavailability of adequate strategies to diagnose and treat DF in the country. This study aimed to determine the prevalence of DF and associated risk factors for PLWD in Harare, Zimbabwe. METHODS: This was a cross-sectional study, employing a quantitative approach...
March 4, 2024: BMC Public Health
https://read.qxmd.com/read/38438431/assessment-of-wound-healing-activity-in-diabetic-mice-treated-with-a-novel-therapeutic-combination-of-selenium-nanoparticles-and-platelets-rich-plasma
#11
JOURNAL ARTICLE
Rania A Karas, Shaimaa Alexeree, Hassan Elsayed, Yasser A Attia
Diabetic wound healing is sluggish, often ending in amputations. This study tested a novel, two-punch therapy in mice-Selenium nanoparticles (Se NPs) and platelet-rich plasma (PRP)-to boost healing. First, a mouse model of diabetes was created. Then, Se NPs were crafted for their impressive antioxidant and antimicrobial powers. PRP, packed with growth factors, was extracted from the mice's blood. Wound healing was tracked for 28 days through photos, scoring tools, and tissue analysis. Se NPs alone spurred healing, and PRP added extra fuel...
March 4, 2024: Scientific Reports
https://read.qxmd.com/read/38435926/knowledge-attitude-and-practice-of-adult-diabetics-regarding-diabetic-foot-ulcers-a-cross-sectional-study-in-saudi-arabia
#12
JOURNAL ARTICLE
Safa H Alkalash, Faisal H Alnashri, Amnah I Alnashri, Khadijah A Alghubayshi, Manar A Alsumaydi, Wael S Alzubaidi, Sarah M Alshuqayfi, Fuad M Alkudaysi, Naeem F Qusty
Background Diabetic foot ulcers (DFUs) are one of the most common and fatal complications of diabetic patients with uncontrolled diabetes mellitus (DM) that may end with their feet amputation. These complications can be prevented through the adherence of diabetic patients to their diabetes management plan and by educating them about risk factors, complications of diabetic foot, and proper foot care. To develop effective health education programs to educate diabetic patients and caregivers regarding diabetic foot and its effective care, we should first identify gaps in patients' knowledge and perception of diabetic foot and evaluate their practice of foot care...
January 2024: Curēus
https://read.qxmd.com/read/38424430/promising-phytoconstituents-in-diabetes-related-wounds-mechanistic-insights-and-implications
#13
JOURNAL ARTICLE
Arjina Sultana, Ranadeep Borgohain, Ashwini Rayaji, Dipankar Saha, Bhrigu Kumar Das
BACKGROUND: The onset of diabetes mellitus (DM), a metabolic disorder characterized by high blood glucose levels and disrupted glucose metabolism, results in 20% of people with diabetes suffering from diabetes-related wounds worldwide. A minor wound, such as a cut or abrasion, can lead to infections and complications in diabetic patients. We must understand the mechanism/s contributing to this delayed wound healing to develop effective prevention strategies. The potential benefits of bioactive phytochemicals for diabetic wound healing have been reported in numerous studies...
February 27, 2024: Current Diabetes Reviews
https://read.qxmd.com/read/38422498/matrix-metalloproteinase-9-testing-of-golden-rice-cookies-with-piper-crocatum-active-extract-for-preventing-foot-ulcers-in-patients-with-diabetes-protocol-for-a-randomized-controlled-trial
#14
JOURNAL ARTICLE
Andina Setyawati, Ariyanti Saleh, Takdir Tahir, Saldy Yusuf, Syahrul Syahrul, Aminuddin Aminuddin, Muhammad Raihan, Nuurhidayat Jafar, Hasyrul Hamzah, Nur Arfian
BACKGROUND: Diabetic foot ulcers (DFUs) present a formidable challenge to both patients and health care systems. DFUs significantly reduce the quality of life for patients, prolong hospital stays, and are the cause of approximately 70,000 lower limb amputations across the globe annually. Prevention of DFUs primarily involves the optimization of blood sugar levels and the effective management of complications, particularly peripheral neuropathy. Golden Rice has been proven to lower blood sugar levels due to its beta-carotene content, and Piper crocatum (P...
February 29, 2024: JMIR Research Protocols
https://read.qxmd.com/read/38419470/appropriateness-of-artificial-intelligence-chatbots-in-diabetic-foot-ulcer-management
#15
JOURNAL ARTICLE
Makoto Shiraishi, Haesu Lee, Koji Kanayama, Yuta Moriwaki, Mutsumi Okazaki
Type 2 diabetes is a significant global health concern. It often causes diabetic foot ulcers (DFUs), which affect millions of people and increase amputation and mortality rates. Despite existing guidelines, the complexity of DFU treatment makes clinical decisions challenging. Large language models such as chat generative pretrained transformer (ChatGPT), which are adept at natural language processing, have emerged as valuable resources in the medical field. However, concerns about the accuracy and reliability of the information they provide remain...
February 28, 2024: International Journal of Lower Extremity Wounds
https://read.qxmd.com/read/38417818/vgg19-demonstrates-the-highest-accuracy-rate-in-a-nine-class-wound-classification-task-among-various-deep-learning-networks-a-pilot-study
#16
JOURNAL ARTICLE
Jun Won Lee, Hi-Jin You, Ji-Hwan Cha, Tae-Yul Lee, Deok-Woo Kim
BACKGROUND: Current literature suggests relatively low accuracy of multi-class wound classification tasks using deep learning networks. Solutions are needed to address the increasing diagnostic burden of wounds on wound care professionals and to aid non-wound care professionals in wound management. OBJECTIVE: To develop a reliable, accurate 9-class classification system to aid wound care professionals and perhaps eventually, patients and non-wound care professionals, in managing wounds...
January 2024: Wounds: a Compendium of Clinical Research and Practice
https://read.qxmd.com/read/38403175/non-pharmacological-interventions-to-improve-cardiovascular-risk-factors-in-people-with-diabetic-foot-disease-a-systematic-review-and-meta-analysis
#17
REVIEW
Patrick Highton, Abdullah Almaqhawi, Maroria Oroko, Harini Sathanapally, Laura Gray, Melanie Davies, David Webb, Frances Game, John Petrie, Solomon Tesfaye, Jonathan Valabhji, Clare Gillies, Kamlesh Khunti
Cardiovascular disease (CVD) risk in those with diabetic foot disease is very high. Non-pharmacological interventions may improve this risk, though no previous evidence synthesis has been completed. This systematic review aimed to investigate the impact of non-pharmacological interventions on CVD risk factors in diabetic ulcer disease. Multiple databases and trials registers were searched from inception to December 6th 2023. We included reports of randomised controlled trials investigating the impact of non-pharmacological interventions on cardiovascular risk in those with type 1 or type 2 diabetes and current or previous diabetic foot disease...
February 23, 2024: Diabetes Research and Clinical Practice
https://read.qxmd.com/read/38402455/diagnosis-and-treatment-of-diabetic-foot-ulcer-complicated-with-lower-extremity-vasculopathy-consensus-recommendation-from-the-chinese-medical-association-cma-chinese-medical-doctor-association-cmda
#18
REVIEW
Kejia Wang, Yunchuan Wang, Wenlong Shi, Kuo Shen, Ke Tao, Rui Ling, Yuesheng Huang, Xiaobing Fu, Dahai Hu
Diabetic foot ulcer complicated with lower extremity vasculopathy is highly prevalent, slow healing and have a poor prognosis. The final progression leads to amputation, or may even be life-threatening, seriously affecting patients' quality of life. The treatment of lower extremity vasculopathy is the focus of clinical practice and is vital to improving the healing process of diabetic foot ulcers. Recently, a number of clinical trials on diabetic foot ulcers with lower extremity vasculopathy have been reported...
March 2024: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/38389641/impact-of-diabetic-foot-ulcer-on-the-health-related-quality-of-life-of-diabetic-patients-in-khartoum-state
#19
JOURNAL ARTICLE
Yusra H Hamid, Mathani Mohammed, Safaa Hamid, Wiaam Mohamedahmed, Osama Ahmed
Background This is a novel study from Sudan aimed at comparing health-related quality of life (HRQoL) between diabetic foot ulcer (DFU) patients and diabetes patients without DFU. Additionally, this study aimed to determine the factors correlating with lower HRQoL. Methodology A descriptive, cross-sectional study with a comparative group was conducted in three diabetes centers in Khartoum, Sudan, in 2020. A total of 120 Sudanese diabetic patients (mean age = 52 years) were divided into two groups, without DFU and with DFU, and interviewed in person...
January 2024: Curēus
https://read.qxmd.com/read/38387871/diabetic-foot-screening-guidelines-and-the-role-of-artificial-intelligence-time-to-turn-the-tide
#20
REVIEW
Cynthia Formosa, Nachiappan Chockalingam, Nikolaos Papanas, Alfred Gatt
Despite medical and technological advancements, foot amputations continue to rise. Thus, the effort of diabetic foot management should be toward prevention and early diagnosis. Healthcare professionals need to be trained, equipped, and supported with adequate resources to be able to identify and deliver appropriate foot care. Every effort should be made to minimize the impact of complications and to ensure prompt access to care for everyone. Artificial intelligence and smart technology could provide a significant opportunity to improve efficiency in diabetes care, which may reduce diabetic foot complications...
February 22, 2024: International Journal of Lower Extremity Wounds
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