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https://www.readbyqxmd.com/read/28934137/evidence-for-involvement-of-il-9-and-il-22-in-cows-milk-allergy-in-infants
#1
Karina V Barros, Vera L Flor Silveira, Marisa S Laranjeira, Neusa F Wandalsen, Susana Passeti, Roberta de Oliveira, Regina V Munekata, Paul S Noakes, Elizabeth A Miles, Philip C Calder
Although allergic inflammation is characterized by a T helper (Th) 2-dominant immune response, the discovery of a role for new T cell subsets in inflammatory diseases has added an additional layer of complexity to the understanding of the pathogeneses of allergic diseases. We evaluated plasma cytokine profiles in infants with cows' milk allergy (CMA), who were being treated with an elimination diet. In a prospective, randomized and controlled study, infants (aged 8.4 ± 3.9 months) with CMA were treated with an elimination diet for 120 days, which replaced cows' milk with a hydrolysed soy protein formula (n = 26) or a free amino acid formula (n = 20)...
September 21, 2017: Nutrients
https://www.readbyqxmd.com/read/28931804/cross-ethnic-meta-analysis-identifies-association-of-the-gpx3-tnip1-locus-with-amyotrophic-lateral-sclerosis
#2
Beben Benyamin, Ji He, Qiongyi Zhao, Jacob Gratten, Fleur Garton, Paul J Leo, Zhijun Liu, Marie Mangelsdorf, Ammar Al-Chalabi, Lisa Anderson, Timothy J Butler, Lu Chen, Xiang-Ding Chen, Katie Cremin, Hong-Weng Deng, Matthew Devine, Janette Edson, Jennifer A Fifita, Sarah Furlong, Ying-Ying Han, Jessica Harris, Anjali K Henders, Rosalind L Jeffree, Zi-Bing Jin, Zhongshan Li, Ting Li, Mengmeng Li, Yong Lin, Xiaolu Liu, Mhairi Marshall, Emily P McCann, Bryan J Mowry, Shyuan T Ngo, Roger Pamphlett, Shu Ran, David C Reutens, Dominic B Rowe, Perminder Sachdev, Sonia Shah, Sharon Song, Li-Jun Tan, Lu Tang, Leonard H van den Berg, Wouter van Rheenen, Jan H Veldink, Robyn H Wallace, Lawrie Wheeler, Kelly L Williams, Jinyu Wu, Xin Wu, Jian Yang, Weihua Yue, Zong-Hong Zhang, Dai Zhang, Peter G Noakes, Ian P Blair, Robert D Henderson, Pamela A McCombe, Peter M Visscher, Huji Xu, Perry F Bartlett, Matthew A Brown, Naomi R Wray, Dongsheng Fan
Cross-ethnic genetic studies can leverage power from differences in disease epidemiology and population-specific genetic architecture. In particular, the differences in linkage disequilibrium and allele frequency patterns across ethnic groups may increase gene-mapping resolution. Here we use cross-ethnic genetic data in sporadic amyotrophic lateral sclerosis (ALS), an adult-onset, rapidly progressing neurodegenerative disease. We report analyses of novel genome-wide association study data of 1,234 ALS cases and 2,850 controls...
September 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/28904807/the-return-of-a-former-foe-syphilis-with-antiphospholipid-syndrome-as-a-cause-of-acute-stroke
#3
Daniela Noakes, Katherine Evans, Rohan Pathansali
This article highlights a rare complication of syphilis infection and the importance of including syphilis and antiphospholipid antibody testing in the acute stroke screen..
September 2017: JRSM Open
https://www.readbyqxmd.com/read/28902423/partitioning-k-space-for-cylindrical-three-dimensional-rapid-acquisition-with-relaxation-enhancement-imaging-in-the-mouse-brain
#4
T Leigh Spencer Noakes, R Mark Henkelman, Brian J Nieman
Three-dimensional rapid acquisition with relaxation enhancement (RARE) scans require the assignment of each phase encode step in two dimensions to an echo in the echo train. Although this assignment is frequently made across the entire Cartesian grid, collection of only the central cylinder of k-space by eliminating the corners in each phase encode dimension reduces the scan time by ~22% with negligible impact on image quality. The recipe for the assignment of echoes to grid points for such an acquisition is less straightforward than for the simple full Cartesian acquisition case, and has important implications for image quality...
September 13, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28887689/-reduced-noak-dose-in-atrial-fibrillation-efficacy-and-safety-compared-with-warfarin
#5
Kerstin Amadori
No abstract text is available yet for this article.
September 8, 2017: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/28875874/use-of-social-media-by-health-professionals-in-south-africa
#6
T D Noakes
No abstract text is available yet for this article.
August 25, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/28835409/towards-a-three-dimensional-framework-of-centrally-regulated-and-goal-directed-exercise-behaviour-a-narrative-review
#7
REVIEW
Andreas Venhorst, Dominic Micklewright, Timothy D Noakes
The Central Governor Model (CGM) ignited a paradigm shift from concepts of catastrophic failure towards central regulation of exercise performance. However, the CGM has focused on the central integration of afferent feedback in homeostatic control. Accordingly, it neglected the important role of volitional self-regulatory control and the integration of affective components inherently attached to all physiological cues. Another limitation is the large reliance on the Gestalt phenomenon of perceived exertion...
August 23, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28799894/meal-specific-food-patterns-and-the-incidence-of-hyperglycemia-in-a-chinese-adult-population
#8
Zumin Shi, Malcolm Riley, Anne Taylor, Manny Noakes
This study aimed to examine the association between meal-specific food patterns and incident hyperglycaemia in a Chinese adult population. Adults aged 20 years and older (n 1056) were followed from 2002 to 2007. Dietary data were collected using a 3-d food record and meal-specific (breakfast, lunch and dinner) food patterns were independently described by factor analysis based on the consumption of thirty-five food groups at each eating occasion. Each food pattern score was recoded as quartiles. Hyperglycaemia was defined as fasting plasma glucose >5·6 mmol/l at baseline and follow-up...
July 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28749972/investigating-asymmetric-salt-profiles-for-nanopore-dna-sequencing-with-biological-porin-mspa
#9
Ian C Nova, Ian M Derrington, Jonathan M Craig, Matthew T Noakes, Benjamin I Tickman, Kenji Doering, Hugh Higinbotham, Andrew H Laszlo, Jens H Gundlach
Nanopore DNA sequencing is a promising single-molecule analysis technology. This technique relies on a DNA motor enzyme to control movement of DNA precisely through a nanopore. Specific experimental buffer conditions are required based on the preferred operating conditions of the DNA motor enzyme. While many DNA motor enzymes typically operate in salt concentrations under 100 mM, salt concentration simultaneously affects signal and noise magnitude as well as DNA capture rate in nanopore sequencing, limiting standard experimental conditions to salt concentrations greater than ~100 mM in order to maintain adequate resolution and experimental throughput...
2017: PloS One
https://www.readbyqxmd.com/read/28724717/can-pre-race-aspirin-prevent-sudden-cardiac-death-during-marathons
#10
EDITORIAL
Arthur J Siegel, Timothy D Noakes
No abstract text is available yet for this article.
July 19, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28670438/neuroanatomy-in-mouse-models-of-rett-syndrome-is-related-to-the-severity-of-mecp2-mutation-and-behavioral-phenotypes
#11
Rylan Allemang-Grand, Jacob Ellegood, Leigh Spencer Noakes, Julie Ruston, Monica Justice, Brian J Nieman, Jason P Lerch
BACKGROUND: Rett syndrome (RTT) is a neurodevelopmental disorder that predominantly affects girls. The majority of RTT cases are caused by de novo mutations in methyl-CpG-binding protein 2 (MECP2), and several mouse models have been created to further understand the disorder. In the current literature, many studies have focused their analyses on the behavioral abnormalities and cellular and molecular impairments that arise from Mecp2 mutations. However, limited efforts have been placed on understanding how Mecp2 mutations disrupt the neuroanatomy and networks of the brain...
2017: Molecular Autism
https://www.readbyqxmd.com/read/28606567/yeast-derived-%C3%AE-1-3-1-6-glucan-upper-respiratory-tract-infection-and-innate-immunity-in-older-adults
#12
Richard Fuller, Michael V Moore, George Lewith, Beth L Stuart, Rory V Ormiston, Helena L Fisk, Paul S Noakes, Philip C Calder
OBJECTIVE: The aims of this study were to test whether yeast-derived β-1,3/1,6 glucan can prevent the occurrence or reduce the severity of upper respiratory tract infection (URTI) and modulate innate immune responses during winter months in community-dwelling older adults. METHODS: This was a double-blind placebo-controlled trial of community-dwelling adults ages 50 to 70 y randomized to once-daily β-1,3/1,6 glucan (Wellmune 250 mg/d; n = 50) or identical placebo capsule (n = 50) over 90 d during winter...
July 2017: Nutrition
https://www.readbyqxmd.com/read/28571586/complement-c5a-c5ar1-signalling-drives-skeletal-muscle-macrophage-recruitment-in-the-hsod1-g93a-mouse-model-of-amyotrophic-lateral-sclerosis
#13
Haitao A Wang, John D Lee, Kah Meng Lee, Trent M Woodruff, Peter G Noakes
BACKGROUND: The terminal pathway of the innate immune complement system is implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). Terminal complement activation leads to generation of C5a, which through its receptor, C5aR1, drives immune cell recruitment and activation. Importantly, genetic or pharmacological blockage of C5aR1 improves motor performance and reduces disease pathology in hSOD1(G93A) rodent models of ALS. In this study, we aimed to explore the potential mechanisms of C5aR1-mediated pathology in hSOD1(G93A) mice by examining their skeletal muscles...
June 1, 2017: Skeletal Muscle
https://www.readbyqxmd.com/read/28493010/multiple-long-bone-cysts-revealed-by-mri-in-trichorhinophalangeal-syndrome-type-ii-predisposing-to-pathological-fractures
#14
Praveen Konala, Nigel Kiely, Charlotte Noakes, Edward Blair, Victor N Cassar-Pullicino
Trichorhinophalangeal syndrome type II is a rare genetic disorder with the few published case reports mainly reporting the radiographic skeletal manifestations. There are no published imaging reports of long bone cysts involving multiple bones in this condition. We report a unique case of bone cysts involving multiple long bones detected with MRI in a patient with trichorhinophalangeal syndrome type II complicated by a subsequent pathological fracture. It is possible that the bone cysts are a previously undescribed feature of this syndrome; however, the evidence is insufficient to establish a definite association...
July 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28437435/infective-respiratory-syncytial-virus-is-present-in-human-cord-blood-samples-and-most-prevalent-during-winter-months
#15
Angela Mary Fonceca, Abha Chopra, Avram Levy, Paul Stanton Noakes, Matthew Wee-Peng Poh, Natasha Leanne Bear, Susan Prescott, Mark Lloyd Everard
BACKGROUND: Human respiratory syncytial virus (RSV) remains the most common cause of severe lower respiratory tract disease amongst infants, and continues to cause annual epidemics of respiratory disease every winter worldwide. Demonstrating placental transmission of viable RSV in human samples is a major paradigm shift in respiratory routes considered likely for RSV transmission. METHODS: Droplet digital PCR (ddPCR) was used to identify RSV present in cord blood mononucleocytes (CBM)...
2017: PloS One
https://www.readbyqxmd.com/read/28374502/the-role-of-digital-breast-tomosynthesis-in-the-breast-assessment-clinic-a-review
#16
REVIEW
Suneeta Mall, Sarah Lewis, Patrick Brennan, Jennie Noakes, Claudia Mello-Thoms
Mammography has long been considered as the primary technique in breast cancer detection and assessment. Despite low specificity, mammography has been preferred over other contemporary techniques such as magnetic resonance imaging (MRI), computed tomography (CT) and ultrasonography (US) due to superior sensitivity and significant health economic benefits. The development of a new technique, a limited angle cone beam pseudo-three-dimensional tomosynthesis, digital breast tomosynthesis (DBT), has gained momentum...
September 2017: Journal of Medical Radiation Sciences
https://www.readbyqxmd.com/read/28321639/brain-oxygenation-declines-in-elite-kenyan-runners-during-a-maximal-interval-training-session
#17
Jordan Santos-Concejero, F Billaut, L Grobler, J Oliván, T D Noakes, R Tucker
PURPOSE: The purpose of this study was to characterise the cerebral oxygenation (Cox) response during a high-intensity interval training session in Kenyan runners, and to examine any relationship with running performance. METHODS: 15 Kenyan runners completed a 5-km time trial (TT) and a Fatigue Training Test on a treadmill (repeated running bouts of 1-km at a pace 5% faster than their mean 5-km TT pace with a 30-s recovery until exhaustion). Changes in Cox were monitored via near-infrared spectroscopy through concentration changes in oxy- and deoxy-haemoglobin (Δ[O2Hb] and Δ[HHb]), tissue oxygenation index (TOI), and total hemoglobin index (nTHI)...
May 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28301326/functional-decline-at-the-aging-neuromuscular-junction-is-associated-with-altered-laminin-%C3%AE-4-expression
#18
Kah Meng Lee, Kirat K Chand, Luke A Hammond, Nickolas A Lavidis, Peter G Noakes
Laminin-α4 is involved in the alignment of active zones to postjunctional folds at the neuromuscular junction (NMJ). Prior study has implicated laminin-α4 in NMJ maintenance, with altered NMJ morphology observed in adult laminin-α4 deficient mice (lama4(-/-)). The present study further investigated the role of laminin-α4 in NMJ maintenance by functional characterization of transmission properties, morphological investigation of synaptic proteins including synaptic laminin-α4, and neuromotor behavioral testing...
March 14, 2017: Aging
https://www.readbyqxmd.com/read/28281204/erratum-to-effect-of-crystallinity-on-electrostatic-charging-in-drypowder-inhaler-formulations
#19
Jennifer Wong, Philip Chi Lip Kwok, Tim Noakes, Ali Fathi, Fariba Dehghani, Hak-Kim Chan
No abstract text is available yet for this article.
March 9, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28277960/seasonal-metabolic-acclimatization-varies-in-direction-and-magnitude-among-populations-of-an-afrotropical-passerine-bird
#20
Matthew J Noakes, Blair O Wolf, Andrew E McKechnie
Avian metabolic responses demonstrate considerable diversity under fluctuating environmental conditions, a well-studied example being the seasonal upregulation of basal metabolic rate (BMR) and summit metabolism (Msum) in temperate species experiencing harsh winters. Fewer studies have examined seasonal metabolic acclimatization in subtropical or tropical species. We investigated seasonal metabolic variation in an Afrotropical ploceid passerine, the white-browed sparrow-weaver (Plocepasser mahali; ∼47 g), at three sites along a climatic gradient of approximately 7°C in winter minimum air temperature (Ta)...
March 2017: Physiological and Biochemical Zoology: PBZ
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