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https://www.readbyqxmd.com/read/29321913/egg-size-and-emergence-timing-affect-morphology-and-behavior-in-juvenile-chinook-salmon-oncorhynchus-tshawytscha
#1
Karen M Cogliati, Julia R Unrein, Heather A Stewart, Carl B Schreck, David L G Noakes
Variation in early life history traits often leads to differentially expressed morphological and behavioral phenotypes. We investigated whether variation in egg size and emergence timing influence subsequent morphology associated with migration timing in juvenile spring Chinook Salmon, Oncorhynchus tshawytscha. Based on evidence for a positive relationship between growth rate and migration timing, we predicted that fish from small eggs and fish that emerged earlier would have similar morphology to fall migrants, while fish from large eggs and individuals that emerged later would be more similar to older spring yearling migrants...
January 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29295857/defects-in-synaptic-transmission-at-the-neuromuscular-junction-precedes-motor-deficits-in-a-tdp-43q331k-transgenic-mouse-model-of-amyotrophic-lateral-sclerosis
#2
Kirat K Chand, Kah Meng Lee, John D Lee, Hao Qiu, Emily F Willis, Nickolas A Lavidis, Massimo A Hilliard, Peter G Noakes
Transactive response DNA-binding protein-43 (TDP-43) is involved in gene regulation via the control of RNA transcription, splicing, and transport. TDP-43 is a major protein component of ubiquinated inclusions that are found in amyotrophic lateral sclerosis (ALS); however, the function of TDP-43 at the neuromuscular junction (NMJ) and its role in ALS pathogenesis is largely unknown. Here, we show that TDP-43Q331K mutation in mice resulted in impaired neurotransmission by age 3 mo, preceding deficits in motor function and motor neuron loss, which were observed from age 10 mo...
January 2, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29295832/so-what-comes-first-the-obesity-or-the-insulin-resistance-and-which-is-more-important
#3
EDITORIAL
Timothy David Noakes
No abstract text is available yet for this article.
January 2018: Clinical Chemistry
https://www.readbyqxmd.com/read/29208630/regulated-alternative-splicing-of-drosophiladscam2%C3%A2-is-necessary-for-attaining-the-appropriate-number-of-photoreceptor-synapses
#4
Sarah K Kerwin, Joshua S S Li, Peter G Noakes, Grace J-E Shin, S S Millard
How the brain makes trillions of synaptic connections using a genome of only 20,000 genes is a major question in modern neuroscience. Alternative splicing is one mechanism that can increase the number of proteins produced by each gene, but its role in regulating synapse formation is poorly understood. In Drosophila, photoreceptors form a synapse with multiple postsynaptic elements including lamina neurons L1 and L2. L1 and L2 express distinct isoforms of the homophilic repulsive protein, Dscam2, and since these isoforms cannot bind to each other, cell-specific expression has been proposed to be necessary for preventing repulsive interactions that could disrupt the synapse...
December 5, 2017: Genetics
https://www.readbyqxmd.com/read/29178536/effects-of-an-energy-restricted-low-carbohydrate-high-unsaturated-fat-low-saturated-fat-diet-versus-a-high-carbohydrate-low-fat-diet-in-type-2-diabetes-a-2-year-randomized-clinical-trial
#5
Jeannie Tay, Campbell H Thompson, Natalie D Luscombe-Marsh, Thomas P Wycherley, Manny Noakes, Jonathan D Buckley, Gary A Wittert, William S Yancy, Grant D Brinkworth
AIM: To examine whether a low-carbohydrate, high unsaturated/low saturated fat diet (LC) improves glycemic control and cardiovascular disease (CVD) risk factors in overweight and obese patients with type 2 diabetes (T2D). METHODS: 115 adults with T2D (mean[SD]; BMI:34.6[4.3]kg/m2 , age:58[7]yrs, HbA1c:7.3[1.1]%) were randomized to one of two planned energy-matched, hypocaloric diets combined with aerobic/resistance exercise (1hr,3d/wk) for 2 years:(1) LC:14% energy as carbohydrate, 28% protein, 58% fat [<10% saturated fat]) or (2) low fat, high-carbohydrate, low glycemic index diet (HC):53% CHO, 17% protein, 30% fat [<10% saturated fat])...
November 27, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29163013/motor-areas-show-altered-dendritic-structure-in-an-amyotrophic-lateral-sclerosis-mouse-model
#6
Matthew J Fogarty, Erica W H Mu, Nickolas A Lavidis, Peter G Noakes, Mark C Bellingham
Objective: Motor neurons (MNs) die in amyotrophic lateral sclerosis (ALS), a clinically heterogeneous neurodegenerative disease of unknown etiology. In human or rodent studies, MN loss is preceded by increased excitability. As increased neuronal excitability correlates with structural changes in dendritic arbors and spines, we have examined longitudinal changes in dendritic structure in vulnerable neuron populations in a mouse model of familial ALS. Methods: We used a modified Golgi-Cox staining method to determine the progressive changes in dendritic structure of hippocampal CA1 pyramidal neurons, striatal medium spiny neurons, and resistant (trochlear, IV) or susceptible (hypoglossal, XII; lumbar) MNs from brainstem and spinal cord of mice over-expressing the human SOD1(G93A) (SOD1) mutation, in comparison to wild-type (WT) mice, at four postnatal (P) ages of 8-15, 28-35, 65-75, and 120 days...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29141975/dietary-strategies-to-reduce-environmental-impact-a-critical-review-of-the-evidence-base
#7
REVIEW
Bradley G Ridoutt, Gilly A Hendrie, Manny Noakes
The food system is a major source of environmental impact, and dietary change has been recommended as an important and necessary strategy to reduce this impact. However, assessing the environmental performance of diets is complex due to the many types of foods eaten and the diversity of agricultural production systems and local environmental settings. To assess the state of science and identify knowledge gaps, an integrative review of the broad topic of environment and diet was undertaken, with particular focus on the completeness of coverage of environmental concerns and the metrics used...
November 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/29126052/field-assessment-of-bacterial-communities-and-total-trihalomethanes-implications-for-drinking-water-networks
#8
Carolina Montoya-Pachongo, Isabel Douterelo, Catherine Noakes, Miller Alonso Camargo-Valero, Andrew Sleigh, Juan-Carlos Escobar-Rivera, Patricia Torres-Lozada
Operation and maintenance (O&M) of drinking water distribution networks (DWDNs) in tropical countries simultaneously face the control of acute and chronic risks due to the presence of microorganisms and disinfection by-products, respectively. In this study, results from a detailed field characterization of microbiological, chemical and infrastructural parameters of a tropical-climate DWDN are presented. Water physicochemical parameters and the characteristics of the network were assessed to evaluate the relationship between abiotic and microbiological factors and their association with the presence of total trihalomethanes (TTHMs)...
November 7, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29078357/revealing-dynamics-of-helicase-translocation-on-single-stranded-dna-using-high-resolution-nanopore-tweezers
#9
Jonathan M Craig, Andrew H Laszlo, Henry Brinkerhoff, Ian M Derrington, Matthew T Noakes, Ian C Nova, Benjamin I Tickman, Kenji Doering, Noah F de Leeuw, Jens H Gundlach
Enzymes that operate on DNA or RNA perform the core functions of replication and expression in all of biology. To gain high-resolution access to the detailed mechanistic behavior of these enzymes, we developed single-molecule picometer-resolution nanopore tweezers (SPRNT), a single-molecule technique in which the motion of polynucleotides through an enzyme is measured by a nanopore. SPRNT reveals two mechanical substates of the ATP hydrolysis cycle of the superfamily 2 helicase Hel308 during translocation on single-stranded DNA (ssDNA)...
November 7, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29051172/modelling-the-process-of-falling-behind-and-its-psychophysiological-consequences
#10
Andreas Venhorst, Dominic Micklewright, Timothy D Noakes
INTRODUCTION: A preceding article investigated the psychophysiological responses to falling behind a performance matched opponent. The following temporally linked cause-effect relationships were hypothesised: falling behind precedes deterioration in valence, deterioration in valence precedes development of an action crisis, experience of an action crisis precedes psychoneuroendocrinological distress response and non-adaptive distress response reduces conduciveness to high performance, thereby preceding performance decrement...
October 19, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28989667/a-combined-experimental-and-theoretical-spectroscopic-protocol-for-determination-of-the-structure-of-heterogeneous-catalysts-developing-the-information-content-of-the-resonance-raman-spectra-of-m1-movo-x
#11
Adam Kubas, Johannes Noak, Annette Trunschke, Robert Schlögl, Frank Neese, Dimitrios Maganas
Absorption and multiwavelength resonance Raman spectroscopy are widely used to investigate the electronic structure of transition metal centers in coordination compounds and extended solid systems. In combination with computational methodologies that have predictive accuracy, they define powerful protocols to study the spectroscopic response of catalytic materials. In this work, we study the absorption and resonance Raman spectra of the M1 MoVO x catalyst. The spectra were calculated by time-dependent density functional theory (TD-DFT) in conjunction with the independent mode displaced harmonic oscillator model (IMDHO), which allows for detailed bandshape predictions...
September 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28983206/response-to-phrase-truncation-in-pubmed-searches
#12
COMMENT
Steven Duffy, Shelley de Kock, Kate Misso, Caro Noake, Janine Ross, Lisa Stirk
No abstract text is available yet for this article.
October 2017: Journal of the Medical Library Association: JMLA
https://www.readbyqxmd.com/read/28934137/evidence-for-involvement-of-il-9-and-il-22-in-cows-milk-allergy-in-infants
#13
Karina V Barros, Vera L Flor Silveira, Marisa S Laranjeira, Neusa F Wandalsen, Susana Passeti, Roberta de Oliveira, Regina V Munekata, Paul S Noakes, Elizabeth A Miles, Philip C Calder
Although allergic inflammation is characterized by a T helper (Th) 2-dominant immune response, the discovery of a role for new T cell subsets in inflammatory diseases has added an additional layer of complexity to the understanding of the pathogeneses of allergic diseases. We evaluated plasma cytokine profiles in infants with cows' milk allergy (CMA), who were being treated with an elimination diet. In a prospective, randomized and controlled study, infants (aged 8.4 ± 3.9 months) with CMA were treated with an elimination diet for 120 days, which replaced cows' milk with a hydrolysed soy protein formula (n = 26) or a free amino acid formula (n = 20)...
September 21, 2017: Nutrients
https://www.readbyqxmd.com/read/28931804/cross-ethnic-meta-analysis-identifies-association-of-the-gpx3-tnip1-locus-with-amyotrophic-lateral-sclerosis
#14
Beben Benyamin, Ji He, Qiongyi Zhao, Jacob Gratten, Fleur Garton, Paul J Leo, Zhijun Liu, Marie Mangelsdorf, Ammar Al-Chalabi, Lisa Anderson, Timothy J Butler, Lu Chen, Xiang-Ding Chen, Katie Cremin, Hong-Weng Deng, Matthew Devine, Janette Edson, Jennifer A Fifita, Sarah Furlong, Ying-Ying Han, Jessica Harris, Anjali K Henders, Rosalind L Jeffree, Zi-Bing Jin, Zhongshan Li, Ting Li, Mengmeng Li, Yong Lin, Xiaolu Liu, Mhairi Marshall, Emily P McCann, Bryan J Mowry, Shyuan T Ngo, Roger Pamphlett, Shu Ran, David C Reutens, Dominic B Rowe, Perminder Sachdev, Sonia Shah, Sharon Song, Li-Jun Tan, Lu Tang, Leonard H van den Berg, Wouter van Rheenen, Jan H Veldink, Robyn H Wallace, Lawrie Wheeler, Kelly L Williams, Jinyu Wu, Xin Wu, Jian Yang, Weihua Yue, Zong-Hong Zhang, Dai Zhang, Peter G Noakes, Ian P Blair, Robert D Henderson, Pamela A McCombe, Peter M Visscher, Huji Xu, Perry F Bartlett, Matthew A Brown, Naomi R Wray, Dongsheng Fan
Cross-ethnic genetic studies can leverage power from differences in disease epidemiology and population-specific genetic architecture. In particular, the differences in linkage disequilibrium and allele frequency patterns across ethnic groups may increase gene-mapping resolution. Here we use cross-ethnic genetic data in sporadic amyotrophic lateral sclerosis (ALS), an adult-onset, rapidly progressing neurodegenerative disease. We report analyses of novel genome-wide association study data of 1,234 ALS cases and 2,850 controls...
September 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/28904807/the-return-of-a-former-foe-syphilis-with-antiphospholipid-syndrome-as-a-cause-of-acute-stroke
#15
Daniela Noakes, Katherine Evans, Rohan Pathansali
This article highlights a rare complication of syphilis infection and the importance of including syphilis and antiphospholipid antibody testing in the acute stroke screen..
September 2017: JRSM Open
https://www.readbyqxmd.com/read/28902423/partitioning-k-space-for-cylindrical-three-dimensional-rapid-acquisition-with-relaxation-enhancement-imaging-in-the-mouse-brain
#16
T Leigh Spencer Noakes, R Mark Henkelman, Brian J Nieman
Three-dimensional rapid acquisition with relaxation enhancement (RARE) scans require the assignment of each phase encode step in two dimensions to an echo in the echo train. Although this assignment is frequently made across the entire Cartesian grid, collection of only the central cylinder of k-space by eliminating the corners in each phase encode dimension reduces the scan time by ~22% with negligible impact on image quality. The recipe for the assignment of echoes to grid points for such an acquisition is less straightforward than for the simple full Cartesian acquisition case, and has important implications for image quality...
September 13, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28887689/-reduced-noak-dose-in-atrial-fibrillation-efficacy-and-safety-compared-with-warfarin
#17
Kerstin Amadori
No abstract text is available yet for this article.
October 2017: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/28875874/use-of-social-media-by-health-professionals-in-south-africa
#18
T D Noakes
No abstract text is available yet for this article.
August 25, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/28835409/towards-a-three-dimensional-framework-of-centrally-regulated-and-goal-directed-exercise-behaviour-a-narrative-review
#19
REVIEW
Andreas Venhorst, Dominic Micklewright, Timothy D Noakes
The Central Governor Model (CGM) ignited a paradigm shift from concepts of catastrophic failure towards central regulation of exercise performance. However, the CGM has focused on the central integration of afferent feedback in homeostatic control. Accordingly, it neglected the important role of volitional self-regulatory control and the integration of affective components inherently attached to all physiological cues. Another limitation is the large reliance on the Gestalt phenomenon of perceived exertion...
August 23, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28799894/meal-specific-food-patterns-and-the-incidence-of-hyperglycemia-in-a-chinese-adult-population
#20
Zumin Shi, Malcolm Riley, Anne Taylor, Manny Noakes
This study aimed to examine the association between meal-specific food patterns and incident hyperglycaemia in a Chinese adult population. Adults aged 20 years and older (n 1056) were followed from 2002 to 2007. Dietary data were collected using a 3-d food record and meal-specific (breakfast, lunch and dinner) food patterns were independently described by factor analysis based on the consumption of thirty-five food groups at each eating occasion. Each food pattern score was recoded as quartiles. Hyperglycaemia was defined as fasting plasma glucose >5·6 mmol/l at baseline and follow-up...
July 2017: British Journal of Nutrition
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