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https://www.readbyqxmd.com/read/29782994/structural-covariance-of-brain-region-volumes-is-associated-with-both-structural-connectivity-and-transcriptomic-similarity
#1
Yohan Yee, Darren J Fernandes, Leon French, Jacob Ellegood, Lindsay S Cahill, Dulcie A Vousden, Leigh Spencer Noakes, Jan Scholz, Matthijs C van Eede, Brian J Nieman, John G Sled, Jason P Lerch
An organizational pattern seen in the brain, termed structural covariance, is the statistical association of pairs of brain regions in their anatomical properties. These associations, measured across a population as covariances or correlations usually in cortical thickness or volume, are thought to reflect genetic and environmental underpinnings. Here, we examine the biological basis of structural volume covariance in the mouse brain. We first examined large scale associations between brain region volumes using an atlas-based approach that parcellated the entire mouse brain into 318 regions over which correlations in volume were assessed, for volumes obtained from 153 mouse brain images via high-resolution MRI...
May 18, 2018: NeuroImage
https://www.readbyqxmd.com/read/29746385/strength-and-sprint-time-changes-in-response-to-repeated-shuttles-between-the-wickets-during-batting-in-cricket
#2
Candice Jo-Anne Christie, Bronwyn Sheppard, David Goble, Lee Pote, Timothy D Noakes
Christie CJ, Sheppard B, Goble D, Pote L, and Noakes TD. Strength and sprint time changes in response to repeated shuttles between the wickets during batting in cricket. J Strength Cond Res XX(X): 000-000, 2018-No studies have investigated the impact of repeated sprints between the wickets on lower-limb strength and sprint performance. Therefore, the purpose of this study was to assess changes in knee extensor (EXT) and flexor (FLEX) strength after repeated sprints between the wickets and to relate these to changes in sprint times...
May 2, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29724505/adjustment-factors-can-improve-estimates-of-food-group-intake-assessed-using-a-short-dietary-assessment-instrument
#3
Gilly A Hendrie, Megan A Rebuli, Rebecca K Golley, Manny Noakes
BACKGROUND: Methods to address misreporting associated with short dietary assessment instruments are needed. OBJECTIVE: Our objective was to develop and evaluate the direct and indirect validity of adjustment factors applied to a short dietary assessment instrument to improve estimates of usual consumption of core and discretionary food and beverage intake. DESIGN: Validation of the Short Food Survey relative to 24-hour recalls was performed...
May 1, 2018: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/29669704/incorporating-a-static-versus-supportive-mobile-phone-app-into-a-partial-meal-replacement-program-with-face-to-face-support-randomized-controlled-trial
#4
Emily Brindal, Gilly A Hendrie, Jill Freyne, Manny Noakes
BACKGROUND: Mobile phone apps may be acceptable to users and could improve retention and adherence over more traditional methods, but there is mixed literature supporting their efficacy. In the weight management space, very little is known about how a mobile phone app integrating features beyond text messaging (short message service) can affect behavior, particularly when combined with face-to-face support. OBJECTIVE: The objective of this study was to examine the effectiveness of a mobile phone app when combined with a partial meal replacement program including face-to-face support...
April 18, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29649556/is-there-a-relationship-between-airborne-and-surface-microbes-in-the-critical-care-environment
#5
J Smith, C A Adams, M F King, C J Noakes, C Robertson, S J Dancer
OBJECTIVE: This study attempted firstly to correlate environmental contamination of air and surfaces in the intensive care unit (ICU); and secondly, to examine any association between environmental contamination and ICU-acquired staphylococcal infection. DESIGN: We screened patients, air and surfaces on 10 sampling days in a mechanically ventilated 10-bed ICU during 10 months. METHODS: Near-patient hand-touch sites (n=500) and air (n=80) were screened for total colony count and Staphylococcus aureus using dipslides, settle plates (passive air sampling) and an MAS-100 slit-sampler (active air sampling)...
April 9, 2018: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29573074/under-utilisation-of-%C3%AE-blockers-in-patients-with-acute-coronary-syndrome-and-comorbid-chronic-obstructive-pulmonary-disease
#6
L Kratzer, P Noakes, J Baumwol, J P Wrobel
BACKGROUND: β-blockers are an established mainstay of therapy in acute coronary syndrome (ACS). Despite substantial evidence for their safety and efficacy in chronic obstructive pulmonary disease (COPD) patients, their use in this population remains limited internationally, likely due to fears of inducing bronchospasm. In Australia, little is known about the use of β-blockers in COPD patients hospitalised for ACS. AIM: To determine if β-blockers are under-prescribed at discharge for patients with COPD hospitalised for ACS compared to patients without a diagnosis of COPD...
March 23, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29532418/the-psychophysiological-determinants-of-pacing-behaviour-and-performance-during-prolonged-endurance-exercise-a-performance-level-and-competition-outcome-comparison
#7
Andreas Venhorst, Dominic P Micklewright, Timothy D Noakes
INTRODUCTION: A three-dimensional framework of centrally regulated and goal-directed exercise behaviour emphasised the integration of distinct sensory-discriminatory, affective-motivational and cognitive-evaluative dimensions that underpin perceived fatigability. This study aimed to capture the complex interdependencies and temporal dynamics in these processes, their interrelations with observed pacing behaviour, performance and biochemical variables as well as their performance level- and competition outcome-dependent variances...
March 12, 2018: Sports Medicine
https://www.readbyqxmd.com/read/29480455/ixekizumab-for-treating-moderate-to-severe-plaque-psoriasis-an-evidence-review-group-perspective-of-a-nice-single-technology-appraisal
#8
REVIEW
Bram L T Ramaekers, Robert F Wolff, Xavier Pouwels, Marije Oosterhoff, Anoukh Van Giessen, Gill Worthy, Caro Noake, Nigel Armstrong, Jos Kleijnen, Manuela A Joore
The National Institute for Health and Care Excellence invited Eli Lilly and Company Ltd, the company manufacturing ixekizumab (tradename Taltz® ), to submit evidence for the clinical and cost effectiveness of ixekizumab. Ixekizumab was compared with tumour necrosis factor-α inhibitors (etanercept, infliximab, adalimumab), ustekinumab, secukinumab, best supportive care and, if non-biological treatment or phototherapy is suitable, also compared with systemic non-biological therapies and phototherapy with ultraviolet B radiation for adults with moderate-to-severe plaque psoriasis...
February 26, 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/29471572/-cardiovascular-medication-in-elderly-patients
#9
Robert H G Schwinger
Elderly people show increased probability to develop atherosclerotic diseases; in consequence heart failure - most often following coronary heart disease - as well as atrial fibrillation is more common. Following guidelines may lead to polypharmacy, i. e. use of more than 5 drugs daily. Thus, drug interactions as well as side effects become more likely; especially in elderly patients reduced kidney function has to be taken into account. Only drugs which have shown to prolong life or to reduce symptoms in controlled clinical trials should be used...
February 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29439463/compliance-with-dietary-guidelines-varies-by-weight-status-a-cross-sectional-study-of-australian-adults
#10
Gilly A Hendrie, Rebecca K Golley, Manny Noakes
Population surveys have rarely identified dietary patterns associated with excess energy intake in relation to risk of obesity. This study uses self-reported food intake data from the validated Commonwealth Scientific and Industrial Research Organisation (CSIRO) Healthy Diet Score survey to examine whether apparent compliance with dietary guidelines varies by weight status. The sample of 185,951 Australian adults were majority female (71.8%), with 30.2%, 35.3% and 31.0% aged between 18-30, 31-50 and 51-70 years respectively...
February 11, 2018: Nutrients
https://www.readbyqxmd.com/read/29438054/geomagnetic-field-influences-upward-movement-of-young-chinook-salmon-emerging-from-nests
#11
Nathan F Putman, Michelle M Scanlan, Amanda M Pollock, Joseph P O'Neil, Ryan B Couture, Joseph S Stoner, Thomas P Quinn, Kenneth J Lohmann, David L G Noakes
Organisms use a variety of environmental cues to orient their movements in three-dimensional space. Here, we show that the upward movement of young Chinook salmon ( Oncorhynchus tshawytscha ) emerging from gravel nests is influenced by the geomagnetic field. Fish in the ambient geomagnetic field travelled farther upwards through substrate than did fish tested in a field with the vertical component inverted. This suggests that the magnetic field is one of several factors that influences emergence from the gravel, possibly by serving as an orientation cue that helps fish determine which way is up...
February 2018: Biology Letters
https://www.readbyqxmd.com/read/29388623/response-to-lessons-from-popper-for-science-paradigm-shifts-scientific-revolutions-and-exercise-physiology
#12
COMMENT
Timothy David Noakes
No abstract text is available yet for this article.
2018: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/29376959/-clinical-experience-with-the-use-of-rivaroxaban-in-the-treatment-of-cancer-patients-with-venous-thrombosis
#13
P F Kravtsov, S E Katorkin, M A Melnicov
The urgency of the problem. The incidence of various thromboembolic complications in patients with oncopathology reaches 5-12%. When treating VTE in patients with oncology it is necessary to choose between two generally recognized alternatives. The recommended two-component scheme of the initiating phase of anticoagulant therapy with subsequent long-term admission of VKA is fraught with the development of clinically significant bleeding during the initial selection of the dose of warfarin and an increased risk of recurrence of VTE...
2018: Khirurgiia
https://www.readbyqxmd.com/read/29374132/michael-pittaway
#14
David Noakes, David Pittaway, Graham 'Nick' Nicholson, Jerry Cook
A widely respected veterinary surgeon and an innovator within the profession, Michael Pittaway was also a man of great charm and huge energy, who applied his skills across a wide range of interests.
January 27, 2018: Veterinary Record
https://www.readbyqxmd.com/read/29359293/-noaks-in-obese-patients-no-problem
#15
Martin H J Wiesen, Guido Michels
No abstract text is available yet for this article.
January 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29321913/egg-size-and-emergence-timing-affect-morphology-and-behavior-in-juvenile-chinook-salmon-oncorhynchus-tshawytscha
#16
Karen M Cogliati, Julia R Unrein, Heather A Stewart, Carl B Schreck, David L G Noakes
Variation in early life history traits often leads to differentially expressed morphological and behavioral phenotypes. We investigated whether variation in egg size and emergence timing influence subsequent morphology associated with migration timing in juvenile spring Chinook Salmon, Oncorhynchus tshawytscha . Based on evidence for a positive relationship between growth rate and migration timing, we predicted that fish from small eggs and fish that emerged earlier would have similar morphology to fall migrants, while fish from large eggs and individuals that emerged later would be more similar to older spring yearling migrants...
January 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29295857/defects-in-synaptic-transmission-at-the-neuromuscular-junction-precedes-motor-deficits-in-a-tdp-43-q331k-transgenic-mouse-model-of-amyotrophic-lateral-sclerosis
#17
Kirat K Chand, Kah Meng Lee, John D Lee, Hao Qiu, Emily F Willis, Nickolas A Lavidis, Massimo A Hilliard, Peter G Noakes
Transactive response DNA-binding protein-43 (TDP-43) is involved in gene regulation via the control of RNA transcription, splicing, and transport. TDP-43 is a major protein component of ubiquinated inclusions that are found in amyotrophic lateral sclerosis (ALS); however, the function of TDP-43 at the neuromuscular junction (NMJ) and its role in ALS pathogenesis is largely unknown. Here, we show that TDP-43Q331K mutation in mice resulted in impaired neurotransmission by age 3 mo, preceding deficits in motor function and motor neuron loss, which were observed from age 10 mo...
January 8, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29295832/so-what-comes-first-the-obesity-or-the-insulin-resistance-and-which-is-more-important
#18
EDITORIAL
Timothy David Noakes
No abstract text is available yet for this article.
January 2018: Clinical Chemistry
https://www.readbyqxmd.com/read/29208630/regulated-alternative-splicing-of-drosophila-dscam2-is-necessary-for-attaining-the-appropriate-number-of-photoreceptor-synapses
#19
Sarah K Kerwin, Joshua Shing Shun Li, Peter G Noakes, Grace Ji-Eun Shin, S Sean Millard
How the brain makes trillions of synaptic connections using a genome of only 20,000 genes is a major question in modern neuroscience. Alternative splicing is one mechanism that can increase the number of proteins produced by each gene, but its role in regulating synapse formation is poorly understood. In Drosophila , photoreceptors form a synapse with multiple postsynaptic elements including lamina neurons L1 and L2. L1 and L2 express distinct isoforms of the homophilic repulsive protein Dscam2, and since these isoforms cannot bind to each other, cell-specific expression has been proposed to be necessary for preventing repulsive interactions that could disrupt the synapse...
February 2018: Genetics
https://www.readbyqxmd.com/read/29178536/effects-of-an-energy-restricted-low-carbohydrate-high-unsaturated-fat-low-saturated-fat-diet-versus-a-high-carbohydrate-low-fat-diet-in-type-2-diabetes-a-2-year-randomized-clinical-trial
#20
Jeannie Tay, Campbell H Thompson, Natalie D Luscombe-Marsh, Thomas P Wycherley, Manny Noakes, Jonathan D Buckley, Gary A Wittert, William S Yancy, Grant D Brinkworth
AIM: To examine whether a low-carbohydrate, high-unsaturated/low-saturated fat diet (LC) improves glycaemic control and cardiovascular disease (CVD) risk factors in overweight and obese patients with type 2 diabetes (T2D). METHODS: A total of 115 adults with T2D (mean [SD]; BMI, 34.6 [4.3] kg/m2 ; age, 58 [7] years; HbA1c, 7.3 [1.1]%) were randomized to 1 of 2 planned energy-matched, hypocaloric diets combined with aerobic/resistance exercise (1 hour, 3 days/week) for 2 years: LC: 14% energy as carbohydrate, 28% as protein, 58% as fat (<10% saturated fat); or low-fat, high-carbohydrate, low-glycaemic index diet (HC): 53% as CHO, 17% as protein, 30% as fat (<10% saturated fat)...
April 2018: Diabetes, Obesity & Metabolism
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