Read by QxMD icon Read


Marie Westwood, Bram Ramaekers, Shona Lang, Nigel Armstrong, Caro Noake, Shelley de Kock, Manuela Joore, Johan Severens, Jos Kleijnen
BACKGROUND: Allergy is a form of immune-mediated exaggerated sensitivity (hypersensitivity) to a substance that is either inhaled, swallowed, injected or comes into contact with the skin. Foreign substances that provoke allergies are called allergens. It has been claimed that multiplex allergen testing may help in diagnosing the cause of symptoms in patients with an unclear cause of allergy or who are allergic to more than one substance. OBJECTIVES: To evaluate multiplex allergen testing [devices that can measure the presence of multiple immunoglobulin E (IgE) antibodies in a patient's blood at the same time], by assessing (1) clinical effectiveness (allergy symptoms, incidence of acute exacerbations, mortality, adverse events of testing and treatment, health-care presentations or admissions, health-related quality of life); (2) effects on treatment (diet, immunotherapy medications, other potential testing); (3) any additional diagnostic information provided by multiplex allergen testing; and (4) cost-effectiveness (cost of different assessment strategies)...
September 2016: Health Technology Assessment: HTA
Lisa J Moran, Grant D Brinkworth, Sean Martin, Thomas P Wycherley, Bronwyn Stuckey, Janna Lutze, Peter M Clifton, Gary A Wittert, Manny Noakes
INTRODUCTION: Obesity is associated with reduced testosterone and worsened erectile and sexual function in men. Weight loss improves these outcomes. High protein diets potentially offer anthropometric and metabolic benefits, but their effects on reproductive and sexual outcomes is not known. AIM: To examine the long-term effects of weight loss with a higher protein or carbohydrate diet on testosterone, sex hormone binding globulin, erectile dysfunction, lower urinary tract symptoms and sexual desire in overweight and obese men...
2016: PloS One
Harini C Krishnan, Eric J Noakes, Lisa C Lyons
The induction, formation and maintenance of memory represent dynamic processes modulated by multiple factors including the circadian clock and sleep. Chronic sleep restriction has become common in modern society due to occupational and social demands. Given the impact of cognitive impairments associated with sleep deprivation, there is a vital need for a simple animal model in which to study the interactions between chronic sleep deprivation and memory. We used the marine mollusk Aplysia californica, with its simple nervous system, nocturnal sleep pattern and well-characterized learning paradigms, to assess the effects of two chronic sleep restriction paradigms on short-term (STM) and long-term (LTM) associative memory...
October 2016: Neurobiology of Learning and Memory
Sean Mark, Stefan Du Toit, Timothy D Noakes, Kim Nordli, Douwette Coetzee, Michael Makin, Shani Van der Spuy, Justin Frey, Jay Wortman
Lifestyle interventions can treat metabolic syndrome and prevent type 2 diabetes mellitus, but they remain underutilised in routine practice. In 2010, an LI model was created in a rural primary care practice and spread with few resources to four other rural practices. A retrospective chart review evaluated changes in health indicators in two practice environments by following 372 participants, mainly women (mean age 52 years). Participants had a mean body mass index of 37 kg/m2at baseline and lost an average of 12% of their initial body weight as a result of the intervention...
August 2016: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
Cruz E Garcia-Rodriguez, Josune Olza, Maria D Mesa, Concepcion M Aguilera, Elizabeth A Miles, Paul S Noakes, Maria Vlachava, Lefkothea-Stella Kremmyda, Norma D Diaper, Keith M Godfrey, Philip C Calder, Angel Gil
OBJECTIVE: The aim of the present study was to assess the maternal and newborn status of erythrocyte fatty acids and the antioxidant defense system after the intake of two portions of salmon per week during late pregnancy. METHODS: Pregnant women (N = 123) were randomly assigned to continue their habitual diet, which was low in oily fish (control group, n = 61) or to consume two 150-g salmon portions per week (salmon group, n = 62) beginning at 20 wk of gestation and lasting until delivery...
June 8, 2016: Nutrition
Thomas P Wycherley, Campbell H Thompson, Jonathan D Buckley, Natalie D Luscombe-Marsh, Manny Noakes, Gary A Wittert, Grant D Brinkworth
BACKGROUND AND AIMS: Very-low carbohydrate diets can improve glycaemic control in patients with type 2 diabetes (T2DM). However, compared to traditional higher carbohydrate, low fat (HighCHO) diets, they have been associated with impaired endothelial function (measured by flow mediated dilatation [FMD]) that is possibly related to saturated fat. This study aimed to examine the effects of a 12-month hypocaloric very-low carbohydrate, low saturated fat (LowCHO) diet compared to an isocaloric HighCHO diet...
September 2016: Atherosclerosis
Andrew E McKechnie, Ben Smit, Maxine C Whitfield, Matthew J Noakes, William A Talbot, Mateo Garcia, Alexander R Gerson, Blair O Wolf
No abstract text is available yet for this article.
August 1, 2016: Journal of Experimental Biology
Matthew J Fogarty, Erica W H Mu, Peter G Noakes, Nickolas A Lavidis, Mark C Bellingham
Amyotrophic lateral sclerosis (ALS) is characterised by the death of upper (corticospinal) and lower motor neurons (MNs) with progressive muscle weakness. This incurable disease is clinically heterogeneous and its aetiology remains unknown. Increased excitability of corticospinal MNs has been observed prior to symptoms in human and rodent studies. Increased excitability has been correlated with structural changes in neuronal dendritic arbors and spines for decades. Here, using a modified Golgi-Cox staining method, we have made the first longitudinal study examining the dendrites of pyramidal neurons from the motor cortex, medial pre-frontal cortex, somatosensory cortex and entorhinal cortex of hSOD1(G93A) (SOD1) mice compared to wild-type (WT) littermate controls at postnatal (P) days 8-15, 28-35, 65-75 and 120...
2016: Acta Neuropathologica Communications
B Adderley, J Carey, J Gibbins, M Lucquiaud, R Smith
Post-combustion CO2 capture (PCC) can be achieved using a variety of technologies. Importantly it is applicable to a wide range of processes and may also be retrofitted in certain cases. This paper covers the use of PCC for low carbon power generation from new natural gas combined cycle (NGCC) plants that are expected to be built in the UK in the 2020s and 2030s and that will run into the 2050s. Costs appear potentially comparable with other low carbon and controllable generation sources such as nuclear or renewables plus storage, especially with the lower gas prices that can be expected in a carbon-constrained world...
October 20, 2016: Faraday Discussions
Flávio O Pires, Carlos A S Dos Anjos, Roberto J M Covolan, Fabiano A Pinheiro, Alan St Clair Gibson, Timothy D Noakes, Fernando H Magalhães, Carlos Ugrinowitsch
We investigated cerebral responses, simultaneously with peripheral and ratings of perceived exertion (RPE) responses, during different VO2MAX-matched aerobic exercise modes. Nine cyclists (VO2MAX of 57.5 ± 6.2 ml·kg(-1)·min(-1)) performed a maximal, controlled-pace incremental test (MIT) and a self-paced 4 km time trial (TT4km). Measures of cerebral (COX) and muscular (MOX) oxygenation were assessed throughout the exercises by changes in oxy- (O2Hb) and deoxy-hemoglobin (HHb) concentrations over the prefrontal cortex (PFC) and vastus lateralis (VL) muscle, respectively...
2016: Frontiers in Physiology
Mateja Smogavec, Alison Cleall, Juliane Hoyer, Damien Lederer, Marie-Cécile Nassogne, Elizabeth E Palmer, Marie Deprez, Valérie Benoit, Isabelle Maystadt, Charlotte Noakes, Alejandro Leal, Marie Shaw, Jozef Gecz, Lucy Raymond, André Reis, Deborah Shears, Knut Brockmann, Christiane Zweier
BACKGROUND: Heterozygous copy number variants (CNVs) or sequence variants in the contactin-associated protein 2 gene CNTNAP2 have been discussed as risk factors for a wide spectrum of neurodevelopmental and neuropsychiatric disorders. Bi-allelic aberrations in this gene are causative for an autosomal-recessive disorder with epilepsy, severe intellectual disability (ID) and cortical dysplasia (CDFES). As the number of reported individuals is still limited, we aimed at a further characterisation of the full mutational and clinical spectrum...
July 20, 2016: Journal of Medical Genetics
M-F King, C J Noakes, P A Sleigh, S Bale, L Waters
This study quantifies the relationship between hand hygiene and the frequency with which healthcare workers (HCWs) touch surfaces in patient rooms. Surface contacts and hand hygiene were recorded in a single-bed UK hospital ward for six care types. Surface contacts often formed non-random patterns, but hygiene before or after patient contact depends significantly on care type (P=0.001). The likelihood of hygiene correlated with the number of surface contacts (95% confidence interval 1.1-5.8, P=0.002), but not with time spent in the room...
September 2016: Journal of Hospital Infection
Kirat K Chand, Kah Meng Lee, Nickolas A Lavidis, Manuel Rodriguez-Valle, Hina Ijaz, Johannes Koehbach, Richard J Clark, Ala Lew-Tabor, Peter G Noakes
Ticks are important vectors of pathogens and secreted neurotoxins with approximately 69 out of 692 tick species having the ability to induce severe toxicoses in their hosts. The Australian paralysis tick (Ixodes holocyclus) is known to be one of the most virulent tick species producing a flaccid paralysis and fatalities caused by a family of neurotoxins known as holocyclotoxins (HTs). The paralysis mechanism of these toxins is temperature dependent and is thought to involve inhibition of acetylcholine levels at the neuromuscular junction...
2016: Scientific Reports
Marika Sboros
No abstract text is available yet for this article.
April 2016: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
Bradley Ridoutt, Gilly Hendrie, Manny Noakes
No abstract text is available yet for this article.
June 13, 2016: Public Health Nutrition
David Guy, Gabriella Ghanem, Andrew Loblaw, Roger Buckley, Beverly Persaud, Patrick Cheung, Hans Chung, Cyril Danjoux, Gerard Morton, Jeff Noakes, Les Spevack, David Hajek, Stanley Flax
INTRODUCTION: We aimed to report on data from the multidisciplinary diagnostic assessment program (DAP) at the Gale and Graham Wright Prostate Centre (GGWPC) at North York General Hospital (NYGH). We assessed referral, diagnosis, and treatment decisions for newly diagnosed prostate cancer (PCa) patients as seen over time, risk stratification, and clinic type to establish a deeper understanding of current decision-making trends. METHODS: From June 2007 to April 2012, 1277 patients who were diagnosed with PCa at the GGWPC were included in this study...
March 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
Andrew E McKechnie, Ben Smit, Maxine C Whitfield, Matthew J Noakes, William A Talbot, Mateo Garcia, Alexander R Gerson, Blair O Wolf
Sandgrouse (Pterocliformes) are quintessential examples of avian adaptation to desert environments, but relatively little is known about the limits to their heat tolerance and evaporative cooling capacity. We predicted that evaporative cooling in Burchell's sandgrouse (Pterocles burchelli) is highly efficient and provides the basis for tolerance of very high air temperature (Ta). We measured body temperature (Tb), resting metabolic rate (RMR) and evaporative water loss (EWL) at Ta between 25°C and ∼58°C in birds exposed to successive increments in Ta Normothermic Tb averaged 39...
July 15, 2016: Journal of Experimental Biology
Nerylee Watson, Kathryn Dyer, Jonathan Buckley, Grant Brinkworth, Alison Coates, Gaynor Parfitt, Peter Howe, Manny Noakes, Karen Murphy
Despite evidence for the benefits of higher-protein (HP) diets in weight loss, their role in type 2 diabetes mellitus (T2DM) management and weight maintenance is not clear. This randomised study compared the effects of a HP diet (38% carbohydrate, 30% protein, 29% fat) to a isocaloric higher-carbohydrate diet (HC: 53%:21%:23%) on cardiometabolic risk factors for 12 weeks in energy restriction (~30% reduction) followed by 12 weeks of energy balance whilst performing regular exercise. Outcomes were measured at baseline and the end of each phase...
2016: Nutrients
J Santos-Concejero, N Tam, D R Coetzee, J Oliván, T D Noakes, R Tucker
The aim of this study was to determine whether gait cycle characteristics are associated with running economy in elite Kenyan runners. Fifteen elite Kenyan male runners completed two constant-speed running sets on a treadmill (12 km ·h(-1) and 20 km ·h(-1)). VO2 and respiratory exchange ratio values were measured to calculate steady-state oxygen and energy cost of running. Gait cycle characteristics and ground contact forces were measured at each speed. Oxygen cost of running at different velocities was 192...
May 7, 2016: Journal of Sports Sciences
Grant D Brinkworth, Thomas P Wycherley, Manny Noakes, Jonathan D Buckley, Peter M Clifton
OBJECTIVE: Compromised bone health is a frequently cited concern of very-low-carbohydrate (LC) diets, although limited data are available from long-term, well-controlled, randomized studies. This study compared the effects of an energy-restricted LC diet and traditional, higher-carbohydrate, low-fat (LF) diet on bone health after 12 mo. METHODS: One hundred eighteen abdominally obese adults were randomized to consume either an energy-restricted (∼6-7 MJ/d [∼1450-1650 kcal/d]), planned isocaloric LC, or LF diet for 12 mo...
September 2016: Nutrition
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"