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https://www.readbyqxmd.com/read/29474997/footwear-generated-dynamic-biomechanical-manipulation-and-perturbation-training-for-chronic-nonspecific-low-back-pain
#1
Se Won Lee, Ratnakar Veeramachaneni, Ibrahim Abou Saleh, Karen Morice, Timothy Tiu, Yungtai Lo, Kevin Frison, Matthew Bartels
BACKGROUND: Home-based therapy optimizing biomechanics and neuromuscular control is increasingly recognized as a treatment option for chronic nonspecific low back pain (CNSLBP). However, its impact on pain, function and gait is limited among patients in a metropolitan area. OBJECTIVE: To evaluate the change of pain, function and gait parameters with home-based therapy using footwear generated biomechanical manipulation and perturbation training (FGBMPT) in a population with CNSLBP in a metropolitan area...
February 20, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29474555/health-related-quality-of-life-of-patients-after-surgery-for-acute-type-a-aortic-dissection
#2
Uyanga Adam, Helmut Habazettl, Katharina Graefe, Hermann Kuppe, Maximilian Wundram, Stephan Dominik Kurz
OBJECTIVES: Acute Type A aortic dissection (ATAAD) and the ensuing surgical therapy may be experienced as a traumatic event by patients. This study aimed at analysing the prevalence of post-traumatic stress disorder (PTSD) and the physical and mental well-being of survivors of surgically treated ATAAD. METHODS: A total of 393 survivors were contacted and asked to fill in various health questionnaires. RESULTS: Two hundred and ten (53%) patients returned the questionnaires...
February 20, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29474319/the-association-of-icu-acuity-with-outcomes-of-patients-at-low-risk-of-dying
#3
Kelly C Vranas, Jeffrey K Jopling, Jennifer Y Scott, Omar Badawi, Michael O Harhay, Christopher G Slatore, Meghan C Ramsey, Michael J Breslow, Arnold S Milstein, Meeta Prasad Kerlin
OBJECTIVE: Many ICU patients do not require critical care interventions. Whether aggressive care environments increase risks to low-acuity patients is unknown. We evaluated whether ICU acuity was associated with outcomes of low mortality-risk patients. We hypothesized that admission to high-acuity ICUs would be associated with worse outcomes. This hypothesis was based on two possibilities: 1) high-acuity ICUs may have a culture of aggressive therapy that could lead to potentially avoidable complications and 2) high-acuity ICUs may focus attention toward the many sicker patients and away from the fewer low-risk patients...
March 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29474176/cost-effectiveness-of-warfarin-medication-therapy-adherence-clinic-versus-usual-medical-clinic-at-kuala-lumpur-hospital
#4
Subramaniam Thanimalai, Asrul Akmal Shafie, Mohamed Azmi Ahmad Hassali, Jeyaindran Sinnadurai
BACKGROUND: Systematic anticoagulation management clinic is recommended to manage patients on chronic warfarin therapy. In Malaysia, the service was introduced as warfarin medication therapy adherence clinic (WMTAC), which is managed by pharmacists with a physician advisory. OBJECTIVES: To assess the cost-effectiveness of WMTAC in comparison with usual medical clinic (UMC), which is managed by medical officers in Kuala Lumpur Hospital, a tertiary referral hospital in Malaysia...
July 17, 2017: Value in Health Regional Issues
https://www.readbyqxmd.com/read/29473781/prediction-of-depression-and-anxiety-via-patient-assessed-tremor-severity-not-physician-reported-motor-symptom-severity-in-patients-with-parkinson-s-disease-or-essential-tremor-who-have-undergone-deep-brain-stimulation
#5
Rebecca L Achey, Erin Yamamoto, Daniel Sexton, Christine Hammer, Bryan S Lee, Robert S Butler, Nicolas R Thompson, Sean J Nagel, Andre G Machado, Darlene A Lobel
OBJECTIVE Deep brain stimulation (DBS) is an effective therapy for movement disorders such as idiopathic Parkinson's disease (PD) and essential tremor (ET). However, some patients who demonstrate benefit on objective motor function tests do not experience postoperative improvement in depression or anxiety, 2 important components of quality of life (QOL). Thus, to examine other possible explanations for the lack of a post-DBS correlation between improved objective motor function and decreased depression or anxiety, the authors investigated whether patient perceptions of motor symptom severity might contribute to disease-associated depression and anxiety...
February 23, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29473380/longitudinal-prospective-observational-type-study-about-determinants-of-renal-resistive-index-variations-in-chronic-renal-failure-patients-treated-with-conventional-medical-and-dietetic-therapy
#6
Simone Brardi, Gabriele Cevenini, Vanni Giovannelli, Giuseppe Romano
OBJECTIVE: This longitudinal prospective observational type study was conceived with the aim to examine the impact on renal resistive index (RRI) of the variables that we can manipulate with therapeutic and or dietetic interventions in a chronic kidney disease population in order to known which of these variables was statistically related to changes in RRI and therefore could become the object of the greatest therapeutic effort. MATERIAL AND METHODS: This study was undertaken between May 2016 to May 2017 in the outpatient nephrology and urology clinic of San Donato Hospital in Arezzo...
December 31, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/29473373/medical-management-in-locally-advanced-and-metastatic-prostate-cancer-does-changes-in-treatment-policy-have-any-specific-effect-on-psa-levels
#7
Murat Bagcioglu, Cristian Surcel, Serkan Ozcan, Cristian Mirvald, Mehmet Ali Karagoz, Mert Ali Karadag, Emre Huri, Kemal Sarica
OBJECTIVE: Androgen deprivation therapy (ADT) is commonly used as a first-line treatment for locally advanced and metastatic prostatic cancer (Pca). There is no consensus about which alternative treatment should be used after the failure of initial ADT. We aimed to investigate the effect of changes in treatment on PSA and testosterone levels. MATERIAL AND METHODS: A total of 120 patients with an established diagnosis of either locally advanced or metastatic Pca in two different centers...
December 31, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/29473359/-comparison-of-the-effects-of-the-intervention-with-electric-thermal-bian-stone-and-air-suction-cup-on-blood-perfusion-at-meridian-points
#8
Pengna Zhao, Yanping Wang, Feifei Gu, Chaozheng Li, Yulong Wei, Guangjun Wang, Weibo Zhang
OBJECTIVE: To observe the impacts of the intervention with electric thermal bian stone and air suction cup on blood perfusion (BP) at meridian points and explore the approach of accurate measurement and regulation of meridian qi and blood balance in "precise acupuncture". METHODS: The laser Doppler line scanner (LDLS) was used to measure BP at bilateral yua n-primary points at the pericardium meridian, the triple energizer meridian, the gallbladder meridian and the liver meridian (small cycle of jueyin to shaoyang meridians) at 31 healthy receptors...
February 12, 2018: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29473181/bridging-to-a-long-term-ventricular-assist-device-with-short-term-mechanical-circulatory-support
#9
Chitaru Kurihara, Masashi Kawabori, Tadahisa Sugiura, Andre C Critsinelis, Suwei Wang, William E Cohn, Andrew B Civitello, O H Frazier, Jeffrey A Morgan
Implanting short-term mechanical circulatory support (MCS) devices as a bridge-to-decision is increasingly popular. However, outcomes have not been well studied in patients who receive short-term MCS before receiving long-term left ventricular assist device (LVAD) support. We analyzed outcomes in our single-center experience with long-term continuous-flow (CF)-LVAD recipients with pre-implantation short-term MCS. From November 2003 through March 2016, 526 patients (mean age, 54.7 ± 13.5 years) with chronic heart failure (mean ejection fraction, 21...
February 23, 2018: Artificial Organs
https://www.readbyqxmd.com/read/29473177/manufacture-of-endothelial-colony-forming-progenitor-cells-from-steady-state-peripheral-blood-leukapheresis-using-pooled-human-platelet-lysate
#10
Georg Siegel, Erika Fleck, Stefanie Elser, Ursula Hermanutz-Klein, Marc Waidmann, Hinnak Northoff, Erhard Seifried, Richard Schäfer
BACKGROUND: Endothelial colony-forming progenitor cells (ECFCs) are promising candidates for cell therapies. However, ECFC translation to the clinic requires optimized isolation and manufacture technologies according to good manufacturing practice (GMP). STUDY DESIGN AND METHODS: ECFCs were manufactured from steady-state peripheral blood (PB) leukapheresis (11 donors), using GMP-compliant technologies including pooled human platelet (PLT) lysate, and compared to human umbilical cord endothelial cells, human aortic endothelial cells, and human cerebral microvascular endothelial cells...
February 22, 2018: Transfusion
https://www.readbyqxmd.com/read/29472893/late-onset-puberty-induction-by-transdermal-estrogen-in-turner-syndrome-girls-a-longitudinal-study
#11
Aneta Monika Gawlik, Magdalena Hankus, Kamila Szeliga, Aleksandra Antosz, Tomasz Gawlik, Kamil Soltysik, Agnieszka Drosdzol-Cop, Krzysztof Wilk, Grzegorz Kudela, Tomasz Koszutski, Ewa Malecka-Tendera
Objective: Estrogen replacement therapy (ERT) for Turner syndrome (TS) is a widely discussed topic; however, the optimal model of ERT for patients with delayed diagnosis and/or initiation of therapy is still unclear, mainly due to insufficient data. We present the results of a prospective observational single-center study in which the efficacy of late-onset puberty induction by one-regimen transdermal ERT in TS girls was evaluated. Methods: The analysis encompassed 49 TS girls (63...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29472872/pharmacoresistant-severe-mental-health-disorders-in-children-and-adolescents-functional-abnormalities-of-cytochrome-p450-2d6
#12
Susanne Thümmler, Emmanuelle Dor, Renaud David, Graziella Leali, Michele Battista, Alexia David, Florence Askenazy, Céline Verstuyft
Background: Severe mental health disorders in children and adolescents represent a major public health problem. Despite adequate drug treatment, some patients develop pharmacoresistant disease. As a consequence, physicians are confronted with prescribing challenges, prolonged hospitalization and increased risk of adverse events, thus aggravating short-, medium-, and long-term prognosis. The majority of psychotropic treatments, particularly antipsychotics and antidepressants, are metabolized at hepatic level by cytochrome P450 (CYP), particularly by CYP3A4 and CYP2D6...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29472700/neuroprotective-agents-in-the-management-of-glaucoma
#13
REVIEW
C Nucci, A Martucci, C Giannini, L A Morrone, G Bagetta, R Mancino
Glaucoma is an optic neuropathy, specifically a neurodegenerative disease characterized by loss of retinal ganglion cells (RGCs) and their axons. The pathogenesis of RGC loss in glaucoma remains incompletely understood and a broad range of possible mechanisms have been implicated. Clinical evidence indicates that lowering intraocular pressure (IOP) does not prevent progression in all patients; therefore, risk factors other than those related to IOP are involved in the disease. The need for alternative, non-IOP-lowering treatments focused at preventing progression, that is, neuroprotectants, has become of interest to both the patient and the physician...
February 23, 2018: Eye
https://www.readbyqxmd.com/read/29472095/dosimetric-evaluation-of-modern-radiation-therapy-techniques-for-left-breast-in-deep-inspiration-breath-hold
#14
Tuomas Koivumäki, Antonella Fogliata, Michele Zeverino, Eeva Boman, Joanna Sierpowska, Raphaël Moeckli, Véronique Vallet, Luca Cozzi, Janne Heikkilä, Anssi Väänänen, Kristiina Vuolukka, Saara Sillanmäki, Jan Seppälä
PURPOSE: The dosimetric differences between four radiation therapy techniques for left sided whole breast irradiation were evaluated side by side in the same patient population. METHODS: Radiotherapy treatment plans were retrospectively created with Accuray TomoDirect (TD), Elekta Volumetric Modulated Arc Therapy (E-VMAT), Varian RapidArc (RA) and Field-in-field (FinF) technique for 20 patients, who had received left breast irradiation during deep-inspiration breath-hold...
January 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29472094/multi-institutional-comparison-of-computer-based-independent-dose-calculation-for-intensity-modulated-radiation-therapy-and-volumetric-modulated-arc-therapy
#15
Tatsuya Kamima, Hiromi Baba, Ryo Takahashi, Mikiko Yamashita, Yasuharu Sugawara, Daisuke Kawai, Toshijiro Yamamoto, Aya Satou, Hidenobu Tachibana
PURPOSE: No multi-institutional studies of computer-based independent dose calculation have addressed the discrepancies among radiotherapy treatment planning systems (TPSs) and the verification programs for intensity modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT). We conducted a multi-institutional study to investigate whether ±5% is a reasonable action level for independent dose calculation for IMRT/VMAT. METHODS: In total, 477 IMRT/VMAT plans for prostate or head and neck (H&N) malignancies were retrospectively analyzed using a modified Clarkson-based commercial verification program...
January 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29472086/image-quality-of-four-dimensional-cone-beam-computed-tomography-obtained-at-various-gantry-rotation-speeds-for-liver-stereotactic-body-radiation-therapy-with-fiducial-markers
#16
Yoshinobu Shimohigashi, Fujio Araki, Masato Maruyama, Keisuke Yonemura, Yuji Nakaguchi, Yudai Kai, Ryo Toya
In this study, qualities of 4D cone-beam CT (CBCT) images obtained using various gantry rotation speeds (GRSs) for liver stereotactic body radiation therapy (SBRT) with fiducial markers were quantitatively evaluated. Abdominal phantom containing a fiducial marker was moved along a sinusoidal waveform, and 4D-CBCT images were acquired with GRSs of 50-200° min-1 . We obtained the 4D-CBCT projection data from six patients who underwent liver SBRT and generated 4D-CBCT images at GRSs of 67-200° min-1 , by varying the number of projection data points...
January 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29472076/robustness-of-vmat-and-3dcrt-plans-toward-setup-errors-in-radiation-therapy-of-locally-advanced-left-sided-breast-cancer-with-dibh
#17
Christer Andre Jensen, Ana María Acosta Roa, Marie Johansen, Jo-Åsmund Lund, Jomar Frengen
PURPOSE: The aim of our study was to evaluate and compare the robustness of treatment plans produced using the volumetric modulated arc-therapy (VMAT) and the standard three-dimensional conformal radiotherapy (3DCRT) techniques by estimating perturbed doses induced by localization offsets for deep inspiration breath-hold (DIBH) in locally advanced breast cancer radiation therapy. METHODS: Twenty patients with left breast carcinoma requiring radiation therapy were analysed in this planning study...
January 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29472008/efficacy-and-safety-of-alirocumab-in-high-risk-patients-with-clinical-atherosclerotic-cardiovascular-disease-and-or-heterozygous-familial-hypercholesterolemia-from-5-placebo-controlled-odyssey-trials
#18
Peter A McCullough, Christie M Ballantyne, Santosh K Sanganalmath, Gisle Langslet, Seth J Baum, Prediman K Shah, Andrew Koren, Jonas Mandel, Michael H Davidson
Patients with previous atherosclerotic cardiovascular disease (ASCVD) and/or heterozygous familial hypercholesterolemia (HeFH) are at high risk of future cardiovascular events. Despite maximally tolerated doses of statins, many patients still have elevated low-density lipoprotein cholesterol (LDL-C) levels. We evaluated the efficacy and safety of alirocumab in patients with ASCVD and/or HeFH on a maximally tolerated dose of statin (rosuvastatin 20 or 40 mg, atorvastatin 40 or 80 mg, or simvastatin 80 mg, or lower doses with an investigator-approved reason) ± other lipid-lowering therapies from 5 placebo-controlled phase 3 trials (52 to 78 weeks)...
February 2, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29471960/overview-of-autosomal-dominant-polycystic-kidney-disease-in-the-south-of-spain
#19
Ana Isabel Morales García, Margarita Martínez Atienza, María García Valverde, Juan Fontes Jimenez, Antonio Martínez Morcillo, M Angustias Esteban de la Rosa, Pablo de Diego Fernández, Miguel García González, Rafael Fernández Castillo, Irene Argüelles Toledo, Juan Antonio Bravo Soto, Rafael Esteban de la Rosa
INTRODUCTION: Although autosomal dominant polycystic kidney disease is the most common hereditary kidney disease, available data tend to be limited to after initiation of renal replacement therapy. OBJECTIVE: To ascertain an overview of autosomal dominant polycystic kidney disease within the health area of Granada in southern Spain. MATERIAL AND METHODS: From January 2007 to December 2016, we collected clinical, family and demographic information about all patients with autosomal dominant polycystic kidney disease, irrespective of whether or not they were treated with RRT, in the Granada health area...
March 2018: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/29471875/pre-treatment-dwi-as-a-predictor-of-overall-survival-in-locally-advanced-pancreatic-cancer-treated-with-cyberknife-radiotherapy-and-sequential-s-1-therapy
#20
Yu Zhang, Xiaofei Zhu, Denghui Liu, Jiaqi Song, Huojun Zhang, Jianping Lu
BACKGROUND: To identify the value of the pre-treatment apparent diffusion coefficient (ADC) derived from diffusion weighted imaging (DWI) in predicting the overall survival (OS) for locally advanced pancreatic cancer (LAPC) treated with Cyberknife followed by sequential S-1 chemotherapy. METHODS: Patients with UICC-T4 LAPC who underwent DWI scan (3.0 Tesla) using two b-values (0, 600 s/mm2 ) in our center between 2015 and 2017 were enrolled. Mean ADCs of the region of interest (ROI) drawn manually on DWI imaging were measured by two independent radiologists at an interval of 1 month...
February 22, 2018: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
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