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Retroperitoneal sarcoma

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https://www.readbyqxmd.com/read/28394870/postoperative-morbidity-after-radical-resection-of-primary-retroperitoneal-sarcoma-a-report-from-the-transatlantic-rps-working-group
#1
Andrea J MacNeill, Alessandro Gronchi, Rosalba Miceli, Sylvie Bonvalot, Carol J Swallow, Peter Hohenberger, Frits Van Coevorden, Piotr Rutkowski, Dario Callegaro, Andrew J Hayes, Charles Honoré, Mark Fairweather, Amanda Cannell, Jens Jakob, Rick L Haas, Milena Szacht, Marco Fiore, Paolo G Casali, Raphael E Pollock, Francesco Barretta, Chandrajit P Raut, Dirk C Strauss
OBJECTIVE: To investigate the safety of radical resection for retroperitoneal sarcoma (RPS). BACKGROUND: The surgical management of RPS frequently involves complex multivisceral resection. Improved oncologic outcomes have been demonstrated with this approach compared to marginal excision, but the safety of radical resection has not been shown in a large study population. METHODS: The Transatlantic Retroperitoneal Sarcoma Working Group (TARPSWG) is an international collaborative of sarcoma centers...
April 7, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28373477/comprehensive-surgical-treatment-as-the-mainstay-of-management-in-retroperitoneal-sarcomas-retrospective-study-from-two-non-sarcoma-specialist-centers
#2
Athanasios Petrou, Anastasia Constantinidou, Michael Kontos, Alexandros Papalampros, Demetrios Moris, Chris Bakoyiannis, Kyriakos Neofytou, George Kourounis, Evangelos Felekouras
BACKGROUND/AIM: Complete resection, surgical expertise and individualization of patient management in comprehensive oncology centres result in better clinical outcomes in patients presenting with retroperitoneal sarcomas. PATIENTS AND METHODS: Clinical outcomes of primary and recurrent retroperitoneal sarcoma resections performed between January 2002 and December 2016 in two large surgical oncology, but non-sarcoma specialist centers, were reviewed to determine the efficacy of complete surgical resection as the principle instrument for treatment...
April 2017: Anticancer Research
https://www.readbyqxmd.com/read/28371454/tumor-biology-remains-the-main-determinant-of-prognosis-in-retroperitoneal-sarcomas-a-14-year-single-center-experience
#3
Deanna Wan Jie Ng, Grace Hwei Ching Tan, Claramae Shulyn Chia, Soo Khee Chee, Richard Quek, Mohamad Farid, Melissa Ching Ching Teo
AIM: To review our experience in the management of retroperitoneal sarcomas (RPSs) in a single institution, with a predominantly Asian population, and identify associated prognostic factors for overall survival (OS), disease-free survival (DFS) and local recurrence. MATERIALS AND METHODS: All RPSs diagnosed and managed at our center between January 2000 and March 2014 were included. Exclusion criteria included patients whose medical records were untraceable and patients who underwent biopsy but did not undergo resection...
March 30, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28330704/an-update-on-non-extremity-soft-tissue-sarcomas
#4
S J Ford, L M Almond, A Gronchi
The management of soft tissue sarcoma is challenging and varied. Centralisation of management in high volume specialist centres has revolutionised outcomes. Surgery remains the mainstay of treatment and is currently the only potentially curative therapy. Retroperitoneal soft tissue sarcoma presents a particular challenge to the surgical oncologist and the concept of extended resection to include surrounding expendable organs taken en bloc with the tumour has now largely been adopted. The use of neoadjuvant and adjuvant therapies for retroperitoneal soft tissue sarcoma is still to be established, although they are employed on a case-specific basis...
March 19, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28265233/leiomyosarcoma-of-the-renal-vein-analysis-of-outcome-and-prognostic-factors-in-the-world-case-series-of-67-patients
#5
Marko Novak, Andraz Perhavec, Katherine E Maturen, Snezana Pavlovic Djokic, Simona Jereb, Darja Erzen
BACKGROUND: Leiomyosarcoma is a rare malignant mesenchymal tumour. Some cases of leiomyosarcoma of the renal vein (LRV) have been reported in the literature, but no analysis of data and search for prognostic factors have been done so far. The aim of this review was to describe the LRV, to analyse overall survival (OS), local recurrence free survival (LRFS) and distant metastases free survival (DMFS) in LRV world case series and to identify significant predictors of OS, LRFS and DMFS. METHODS: Cases from the literature based on PubMed search and a case from our institution were included...
March 1, 2017: Radiology and Oncology
https://www.readbyqxmd.com/read/28152173/post-relapse-outcomes-after-primary-extended-resection-of-retroperitoneal-sarcoma-a-report-from-the-trans-atlantic-rps-working-group
#6
Andrea J MacNeill, Rosalba Miceli, Dirk C Strauss, Sylvie Bonvalot, Peter Hohenberger, Frits Van Coevorden, Piotr Rutkowski, Dario Callegaro, Andrew J Hayes, Charles Honoré, Mark Fairweather, Amanda Cannell, Jens Jakob, Rick L Haas, Milena Szacht, Marco Fiore, Paolo G Casali, Raphael E Pollock, Chandrajit P Raut, Alessandro Gronchi, Carol J Swallow
BACKGROUND: Despite a radical surgical approach to primary retroperitoneal sarcoma (RPS), many patients experience locoregional and/or distant recurrence. The objective of this study was to analyze post-relapse outcomes for patients with RPS who had initially undergone surgical resection of their primary tumor at a specialist center. METHODS: All consecutive patients who underwent macroscopically complete resection for primary RPS at 8 high volume centers from January 2002 to December 2011 were identified, and those who developed local recurrence (LR) only, distant metastasis (DM) only, or synchronous local recurrence and distant metastasis (LR+DM) during the follow-up period were included...
February 2, 2017: Cancer
https://www.readbyqxmd.com/read/28147251/incidence-and-adverse-prognostic-implications-of-histopathologic-organ-invasion-in-primary-retroperitoneal-sarcoma
#7
Mark Fairweather, Jiping Wang, Vickie Y Jo, Elizabeth H Baldini, Monica M Bertagnolli, Chandrajit P Raut
BACKGROUND: The incidence of histopathologic organ invasion (HOI) in retroperitoneal sarcoma (RPS) is not well described. We reviewed our experience to investigate the rate and prognostic implications of HOI. STUDY DESIGN: Patients with primary RPS who underwent surgery at our institution were reviewed. Histopathologic organ invasion was defined as microscopic organ invasion confirmed by re-review of pathology slides by an expert sarcoma pathologist. Impact of HOI on the crude cumulative incidence of locoregional recurrence, distant recurrence, and overall survival rates was analyzed...
January 29, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28127762/improved-local-control-with-an-aggressive-strategy-of-preoperative-with-or-without-intraoperative-radiation-therapy-combined-with-radical-surgical-resection-for-retroperitoneal-sarcoma
#8
Melissa A Hull, George Molina, Andrzej Niemierko, Alex B Haynes, Alex Jacobson, Karen De Amorim Bernstein, Yen-Lin Chen, Thomas F DeLaney, John T Mullen
BACKGROUND AND OBJECTIVES: We sought to examine our outcomes with advanced preoperative and intraoperative radiation therapy (XRT) combined with aggressive en bloc surgical resection of retroperitoneal sarcoma (RPS) as a strategy to minimize the risk of local recurrence (LR). METHODS: From 2003 to 2013, 46 patients with RPS received preoperative XRT followed by radical en bloc surgical resection, with or without intraoperative electron radiation therapy (IOERT)...
January 27, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28126006/significant-benefits-in-survival-by-the-use-of-surgery-combined-with-radiotherapy-for-retroperitoneal-soft-tissue-sarcoma
#9
Sven Hager, Frank Makowiec, Karl Henne, Ulrich T Hopt, Uwe A Wittel
BACKGROUND: To report the effect of intraoperative electron beam radiotherapy (IOERT) and external beam radiotherapy (EBRT) in addition to surgery as well as to evaluate the role of resectable local recurrence for long-term prognosis. METHODS: In 53 patients who underwent surgery for retroperitoneal soft tissue sarcoma (RSTS) from 2001 to 2014 prognostic and epidemiologic factors were reviewed retrospectively to analyze their impact on survival and recurrence. RESULTS: Twenty three patients (50%) had surgery plus radiotherapy, 23 (50%) had surgery only...
January 26, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28101168/ct-guided-125-i-seed-implantation-for-inoperable-retroperitoneal-sarcoma-a-technique-for-delivery-of-local-tumor-brachytherapy
#10
Biao Yang, Wen-Hao Guo, Ting Lan, Fang Yuan, Guan-Jian Liu, Rui-Yu Zan, Xin You, Qiao-Yue Tan, Zheng-Yin Liao
Radical surgery is currently the first treatment of choice for retroperitoneal soft tissue sarcoma (RSTS). However, the prognosis of RSTS remains poor due to ineffective local control and a high incidence of metastasis after surgical resection. Brachytherapy has been shown to safely provide local radiotherapy for numerous types of cancer when used alone or in combination with surgical resection, but has not been well characterized in the management of RSTS. The aim of this study was to evaluate CT-guided 125I seed implantation for local control and pain relief in the treatment of inoperable RSTS...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28100249/intraoperative-radiation-therapy-iort-in-soft-tissue-sarcoma
#11
REVIEW
Falk Roeder, Robert Krempien
Soft-tissue sarcoma (STS) represent a rare tumor entity, accounting for less than 1% of adult malignancies. The cornerstone of curative intent treatment is surgery with free margins, although the extent of the surgical approach has been subject to change in the last decades. Multimodal approaches usually including radiation therapy have replaced extensive surgical procedures in order to preserve functionality while maintaining adequate local control. However, the possibility to apply adequate radiation doses by external beam radiation therapy (EBRT) can be limited in some situation especially in case of directly adjacent organs at risk with low radiation tolerance...
January 19, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28098568/giant-retroperitoneal-dedifferentiated-liposarcoma
#12
Kemal Beksac, Bulent Aksel, Fisun Ardic Yukruk, Olcay Kandemir
INTRODUCTION: Liposarcoma is the most frequent type of retroperitoneal sarcomas. Dedifferentiated liposarcoma is the least common subtype and is an extremely rare tumor. CASE REPORT: We present the case of a 53-year-old male who was referred with a giant retroperitoneal mass. The patients' mass was deemed unresectable by the previous institution and received chemotherapy with no benefit. We macroscopically removed the 38x32 cm mass with right nefrectomy. Pathological examination revealed dedifferentiated liposarcoma...
January 16, 2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/28074298/effect-of-intraoperative-radiotherapy-in-the-treatment-of-retroperitoneal-sarcoma
#13
Liz B Wang, David McAneny, Gerard Doherty, Teviah Sachs
BACKGROUND: Current National Comprehensive Cancer Network guidelines for the treatment of retroperitoneal sarcomas (RPS) endorse surgical resection, but the role of radiotherapy (RT) is less clear. We investigate the utilization and benefits of intraoperative RT (IORT) in the treatment of RPS. METHODS: We queried the Surveillance, Epidemiology and End Results (SEER) database (1988-2013) for the utilization of IORT and perioperative external beam RT (EBRT) in patients who underwent surgical resection of RPS...
January 10, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28057392/primary-retroperitoneal-soft-tissue-sarcoma-imaging-appearances-pitfalls-and-diagnostic-algorithm
#14
REVIEW
C Messiou, E Moskovic, D Vanel, C Morosi, R Benchimol, D Strauss, A Miah, H Douis, W van Houdt, S Bonvalot
Although retroperitoneal sarcomas are rare tumours, they can be encountered by a wide variety of clinicians as they can be incidental findings on imaging or present with non specific symptoms and signs. Surgical resection can offer hope of cure and patient outcomes are improved when patients are managed in high-volume specialist centers. Failure to recognize retroperitoneal sarcomas on imaging can lead to inappropriate management in inexperienced centers. Therefore it is critical that a diagnosis of retroperitoneal sarcoma should be considered in the differential diagnosis of a retroperitoneal mass with prompt referral to a soft tissue sarcoma unit...
December 9, 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28048758/su-f-t-90-patterns-of-electron-iort-treatments-in-the-u-s-europe-and-asia
#15
S Adamczyk, D Goer, R Ash
PURPOSE: We analyzed data collected from worldwide centers active in electron IORT with a focus on the technical variables of the treatment. Particular attention was given to the dominant tumor sites. METHODS: 54 Mobetron users from 14 countries in clinical operation prior to December 31, 2014, were invited to participate in this study. 29 centers contributed to this survey in sufficient detail to be included in this report. 6,035 patients were treated since 1997...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28012782/epithelioid-hemangioendothelioma-presenting-as-inferior-vena-cava-obstruction-diagnosed-using-an-endovascular-thrombectomy-device
#16
Praveen Balraj, Loay Kabbani, Jeff Mathews, Francis Tinney, Scott Schwartz, David Kwon, Felix Braun, Sara Wasilenko
Epithelioid hemangioendothelioma is a rare vascular sarcoma that arises from the lining (intima) of blood vessels. We report a case of a 43-year-old male patient, who presented with inferior vena cava (IVC) obstruction and acute bilateral lower extremity deep vein thrombosis. Mechanical thrombectomy was performed with an endovascular thrombectomy device, followed by stent placement in the IVC. The initial pathology on the retrieved specimen obtained from the thrombectomy device revealed an undifferentiated neoplasm, and definitive surgical resection of the retroperitoneal soft-tissue tumor of the IVC documented a rare case of epithelioid hemangioendothelioma...
December 22, 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27919577/primary-cic-dux4-round-cell-sarcoma-of-the-kidney-a-treatment-refractory-tumor-with-poor-outcome
#17
Sébastien Bergerat, Philippe Barthelemy, Pascal Mouracade, Hervé Lang, Christian Saussine, Véronique Lindner, Didier Jacqmin
The CIC-DUX4 sarcoma is a subset of the undifferentiated small round cell sarcoma family, presently recognized as a new clinicopathological entity. It is a rare and highly aggressive tumor usually arising in the soft parts of the limbs and the trunk. Only a very few cases of primitive visceral CIC-DUX4 have been hitherto described. We report the case of a 29 year-old male patient with a primary CIC-DUX4 sarcoma of the kidney with lung metastasis. The outcome of the disease was rapidly unfavorable. Despite radical nephrectomy, the patient experienced an early local retroperitoneal recurrence associated with lung and liver metastases...
February 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/27914772/vascular-reconstruction-after-retroperitoneal-and-lower-extremity-sarcoma-resection
#18
M Wortmann, I Alldinger, D Böckler, A Ulrich, A Hyhlik-Dürr
PURPOSE: Soft tissue sarcomas (STS) of the retroperitoneum and the lower limb with invasion of major blood vessels are very rare malignancies. This study analyses the outcome of patients with vascular replacement during resection of STS of the retroperitoneum and the lower extremity with either arterial or concomitant arterial and venous infiltration. METHODS: Patients with vascular replacement during resection of sarcoma of the retroperitoneum and the lower extremity between 1990 and 2014 were included in this retrospective single center study...
February 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27891213/uk-guidelines-for-the-management-of-soft-tissue-sarcomas
#19
REVIEW
Adam Dangoor, Beatrice Seddon, Craig Gerrand, Robert Grimer, Jeremy Whelan, Ian Judson
Soft tissue sarcomas (STS) are rare tumours arising in mesenchymal tissues, and can occur almost anywhere in the body. Their rarity, and the heterogeneity of subtype and location means that developing evidence-based guidelines is complicated by the limitations of the data available. However, this makes it more important that STS are managed by teams, expert in such cases, to ensure consistent and optimal treatment, as well as recruitment to clinical trials, and the ongoing accumulation of further data and knowledge...
2016: Clinical Sarcoma Research
https://www.readbyqxmd.com/read/27879144/-recurrent-retroperitoneal-sarcoma
#20
J Dítě, J Froněk
Retroperitoneal sarcomas are rare malignant neoplasms that are often diagnosed late because of their typical nonspecific symptomatology. Radical surgical resection, if possible given the local anatomical conditions, is the most important treatment modality. However, even if the surgery is feasible and successful, the prognosis of retroperitoneal sarcoma is not good. The most frequent type of recurrence is local recurrence, and radical surgical resection remains the most important treatment modality even in such cases...
2016: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
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