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JOURNAL ARTICLE
Jannick Schneider, Clemens Striebing, Katharina Hochfeld, Timo Lorenz
OBJECTIVES: Addressing the lack of German-language instruments, this study aims to develop a questionnaire that enables the measurement of work values. According to the theory of basic human values (Schwartz, 1992), a culturally fitting questionnaire is validated by covering constructs in the four broader dimensions of Social, Prestige, Intrinsic, and Extrinsic work values. Convergent, discriminant and incremental congruent validity are assessed. METHOD: Data were collected in a cross-sectional online-based panel survey...
2024: Frontiers in Psychology
#2
JOURNAL ARTICLE
Julia Greenberg, Kelly Astudillo, Steven J Frucht, Adeen Flinker, Giulietta M Riboldi
INTRODUCTION: Given the unique natural history of GBA -related Parkinson's disease ( GBA -PD) and the potential for novel treatments in this population, genetic testing prioritization for the identification of GBA -PD patients is crucial for prognostication, individualizing treatment, and stratification for clinical trials. Assessing the predictive value of certain clinical traits for the GBA -variant carrier status will help target genetic testing in clinical settings where cost and access limit its availability...
2024: Clinical parkinsonism & related disorders
#3
JOURNAL ARTICLE
Yun-Da Li, Yu-Chi Liu, Yu-Xuan Jiang, Ahmed Namisy, Wen-Hsin Chung, Ying-Hsuan Sun, Shu-Yun Chen
BACKGROUND: Luffa (Luffa spp.) is an economically important crop of the Cucurbitaceae family, commonly known as sponge gourd or vegetable gourd. It is an annual cross-pollinated crop primarily found in the subtropical and tropical regions of Asia, Australia, Africa, and the Americas. Luffa serves not only as a vegetable but also exhibits medicinal properties, including anti-inflammatory, antidiabetic, and anticancer effects. Moreover, the fiber derived from luffa finds extensive applications in various fields such as biotechnology and construction...
April 22, 2024: BMC Plant Biology
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JOURNAL ARTICLE
May El Hachem, Andrea Diociaiuti, Giovanna Zambruno, Tonia Samela, Francesca Ferretti, Claudia Carnevale, Renata Linertová, Christine Bodemer, Dédée F Murrell, Damiano Abeni
BACKGROUND: Inherited epidermolysis bullosa (EB) is a clinically and genetically heterogeneous group of skin fragility disorders characterized by blister formation following minor trauma. Four major types are distinguished based on the level of cleavage within the skin. Most EB forms present severely disabling cutaneous and systemic signs and symptoms. Management relies on daily time-consuming and distressing topical medications, and symptomatic treatment of systemic findings. Disease manifestations, symptoms, and daily care strongly affect patient and caregiver quality of life (QoL)...
April 19, 2024: Italian Journal of Pediatrics
#5
JOURNAL ARTICLE
Zewen Sun, Lin Pan, Aowen Tian, Peng Chen
The prevalence of COVID-19 critical illness varies across ethnicities, with recent studies suggesting that genetic factors may contribute to this variation. The aim of this study was to investigate natural selection signals of genes associated with critically-ill COVID-19 in sub-Saharan Africans. Severe COVID-19 SNPs were obtained from the HGI website. Selection signals were assessed in 661 sub-Sahara Africans from 1000 Genomes Project using integrated haplotype score (iHS), cross-population extended haplotype homozygosity (XP-EHH), and fixation index (Fst)...
April 16, 2024: Infection, Genetics and Evolution
#6
JOURNAL ARTICLE
Matuszkiewicz Mateusz, Grądzielewska Agnieszka, Święcicka Magdalena, Ozturk Alperen, Mokrzycka Monika, Igbari Aramide Dolapo, Song Jie, Kilian Andrzej, Rakoczy-Trojanowska Monika
BACKGROUND: Leaf rust (LR) is among the most destructive fungal diseases of rye (Secale cereale L.). Despite intensive research using various analytical and methodological approaches, such as quantitative trait locus (QTL) mapping, candidate gene expression analysis, and transcriptome sequencing, the genetic basis of the rye immune response to LR remains unclear. RESULTS: A genome-wide association study was employed to detect QTLs controlling the immune response to LR of rye...
April 17, 2024: BMC Plant Biology
#7
JOURNAL ARTICLE
Nicola J Wyatt, Hannah Watson, Carl A Anderson, Nicholas A Kennedy, Tim Raine, Tariq Ahmad, Dean Allerton, Michelle Bardgett, Emma Clark, Dawn Clewes, Cristina Cotobal Martin, Mary Doona, Jennifer A Doyle, Katherine Frith, Helen C Hancock, Ailsa L Hart, Victoria Hildreth, Peter M Irving, Sameena Iqbal, Ciara Kennedy, Andrew King, Sarah Lawrence, Charlie W Lees, Robert Lees, Laura Letchford, Trevor Liddle, James O Lindsay, Rebecca H Maier, John C Mansfield, Julian R Marchesi, Naomi McGregor, Rebecca E McIntyre, Jasmin Ostermayer, Tolulope Osunnuyi, Nick Powell, Natalie J Prescott, Jack Satsangi, Shriya Sharma, Tara Shrestha, Ally Speight, Michelle Strickland, James Ms Wason, Kevin Whelan, Ruth Wood, Gregory R Young, Xinyue Zhang, Miles Parkes, Christopher J Stewart, Luke Jostins-Dean, Christopher A Lamb
INTRODUCTION: Characterised by chronic inflammation of the gastrointestinal tract, inflammatory bowel disease (IBD) symptoms including diarrhoea, abdominal pain and fatigue can significantly impact patient's quality of life. Therapeutic developments in the last 20 years have revolutionised treatment. However, clinical trials and real-world data show primary non-response rates up to 40%. A significant challenge is an inability to predict which treatment will benefit individual patients...
April 17, 2024: BMJ Open
#8
JOURNAL ARTICLE
Chaohui Bao, Tingting Tan, Shan Wang, Chenxu Gao, Chang Lu, Siyue Yang, Yizhu Diao, Lulu Jiang, Duohui Jing, Liye Chen, Haitao Lv, Hai Fang
Cross-disease genome-wide association studies (GWASs) unveil pleiotropic loci, mostly situated within the non-coding genome, each of which exerts pleiotropic effects across multiple diseases. However, the challenge "W-H-W" (namely, whether, how, and in which specific diseases pleiotropy can inform clinical therapeutics) calls for effective and integrative approaches and tools. We here introduce a pleiotropy-driven approach specifically designed for therapeutic target prioritization and evaluation from cross-disease GWAS summary data, with its validity demonstrated through applications to two systems of disorders (neuropsychiatric and inflammatory)...
April 15, 2024: Cell Rep Methods
#9
JOURNAL ARTICLE
Xingxing Xie, Jie Zhang, Fujing Huang, Ling Fan
Abrocitinib is a highly selective Janus kinase 1 (JAK1) inhibitor that can block a multitude of inflammatory signaling pathways that underlie atopic dermatitis (AD). In addition, abrocitinib inhibits JAK1 signaling in sensory neurons to alleviate acute and chronic pruritus during AD. However, substantial variations in efficacy and safety risks remain due to variations in doses applied in clinical use. Therefore for the present study, differences in the efficacy and tolerability of 100 and 200 mg abrocitinib for treating pruritus and eczema symptoms in patients with moderate-to-severe AD were evaluated compared with placebo...
May 2024: Biomedical Reports
#10
JOURNAL ARTICLE
Z Alireza, M Maleeha, M Kaikkonen, V Fortino
Machine learning (ML) methods are increasingly becoming crucial in genome-wide association studies for identifying key genetic variants or SNPs that statistical methods might overlook. Statistical methods predominantly identify SNPs with notable effect sizes by conducting association tests on individual genetic variants, one at a time, to determine their relationship with the target phenotype. These genetic variants are then used to create polygenic risk scores (PRSs), estimating an individual's genetic risk for complex diseases like cancer or cardiovascular disorders...
April 16, 2024: Journal of Translational Medicine
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JOURNAL ARTICLE
Aimei Bai, Tianzi Zhao, Yan Li, Feixue Zhang, Haibin Wang, Sayyed Hamad Ahmad Shah, Li Gong, Tongkun Liu, Yuhui Wang, Xilin Hou, Ying Li
Two major-effect QTL GlcA07.1 and GlcA09.1 for green leaf color were fine mapped into 170.25 kb and 191.41 kb intervals on chromosomes A07 and A09, respectively, and were validated by transcriptome analysis. Non-heading Chinese cabbage (NHCC) is a leafy vegetable with a wide range of green colors. Understanding the genetic mechanism behind broad spectrum of green may facilitate the breeding of high-quality NHCC. Here, we used F2 and F7:8 recombination inbred line (RIL) population from a cross between Wutacai (dark-green) and Erqing (lime-green) to undertake the genetic analysis and quantitative trait locus (QTL) mapping in NHCC...
April 15, 2024: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
#12
JOURNAL ARTICLE
Hongliang Ma, Yu Zhao, Wenxiu He, Jiwen Wang, Qianqian Hu, Kehan Chen, Lianlin Yang, Yonglin Ma
Rosmarinic acid (RA), Tanshinone IIA (Tan IIA), and Salvianolic acid B (Sal B) are crucial compounds found in Salvia miltiorrhiza. Quickly predicting these components can aid in ensuring the quality of S. miltiorrhiza. Spectral preprocessing and variable selection are essential processes in quantitative analysis using near infrared spectroscopy (NIR). A novel hybrid variable selection approach utilizing iVISSA was employed in this study to enhance the quantitative measurement of RA, Tan IIA, and Sal B contents in S...
April 9, 2024: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
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JOURNAL ARTICLE
Wenhuizi Sun, Ping Xu, Kefei Gao, Wenqin Lian, Xiang Sun
There are hundreds of prognostic models for ovarian cancer. These genes are based on different gene classes, and there are many ways to construct the models. Therefore, this paper aims to build the most stable prognostic evaluation system known to date through 101 machine learning strategies. We combined 101 algorithm combinations with 10 machine learning algorithms to create antigen presentation-associated genetic markers (AIDPS) with outstanding precision and steady performance. The inclusive set of algorithms comprises the elastic network (Enet), Ridge, stepwise Cox, Lasso, generalized enhanced regression model (GBM), random survival forest (RSF), supervised principal component (SuperPC), Cox partial least squares regression (plsRcox), survival support vector machine (Survival-SVM)...
April 2024: Journal of Cellular and Molecular Medicine
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JOURNAL ARTICLE
Chang Yin, Haoran Shi, Peng Zhou, Yuwei Wang, Xuzhe Tao, Zongjun Yin, Xiaodong Zhang, Yang Liu
The need for sufficient reference population data poses a significant challenge in breeding programs aimed at improving pig farming on a small to medium scale. To overcome this hurdle, investigating the advantages of combing reference populations of varying sizes is crucial for enhancing the accuracy of the genomic estimated breeding value (GEBV). Genomic selection (GS) in populations with limited reference data can be optimized by combining populations of the same breed or related breeds. This study focused on understanding the effect of combing different reference group sizes on the accuracy of GS for determining the growth effectiveness and percentage of lean meat in Yorkshire pigs...
April 4, 2024: Animals: An Open Access Journal From MDPI
#15
JOURNAL ARTICLE
Shuguang Han, Qingtong Zheng, Zixuan Zheng, Jie Su, Xiaohua Liu, Changzhou Shi, Bo Li, Xuanxuan Zhang, Minghao Zhang, Qian Yu, Ziwei Hou, Ting Li, Bin Zhang, Yong Lin, Ge Wen, Yanjia Deng, Kai Liu, Kai Xu
Previous large-sample postmortem study revealed that the expression of miR-1202 in brain tissues from Brodmann area 44 (BA44) was dysregulated in patients with major depressive disorder (MDDs). However, the specific in vivo neuropathological mechanism of miR-1202 as well as its interplay with BA44 circuits in the depressed brain are still unclear. Here, we performed a case-control study with imaging-genetic approach based on resting-state functional magnetic resonance imaging (MRI) data and miR-1202 quantification from 110 medication-free MDDs and 102 healthy controls...
April 10, 2024: Journal of Affective Disorders
#16
JOURNAL ARTICLE
Barbara Gravel, Alexandre Renaux, Sofia Papadimitriou, Guillaume Smits, Ann Nowé, Tom Lenaerts
MOTIVATION: Whole exome sequencing (WES) has emerged as a powerful tool for genetic research, enabling the collection of a tremendous amount of data about human genetic variation. However, properly identifying which variants are causative of a genetic disease remains an important challenge, often due to the number of variants that need to be screened. Expanding the screening to combinations of variants in two or more genes, as would be required under the oligogenic inheritance model, simply blows this problem out of proportion...
April 11, 2024: Bioinformatics
#17
JOURNAL ARTICLE
Khadija Mansour, Nadia Ben Fredj, Helmi Ammar, Haifa Ben Romdhane, Ahmed Mhalla, Amel Chaabane, Zohra Chadli, Karim Aouam
Clozapine is characterized by a large within- and between-patient variability in its pharmacokinetics, attributed to non-genetic and genetic factors. A cross-sectional analysis of clozapine trough concentration (Clz C0) issued from Tunisian schizophrenic patients was collected and analysed using a nonparametric modelling approach. We assessed the impact of demographic covariates (age, weight and sex), patient's habits (smoking status, alcohol and caffeine intake) and the genetic factors (CYP1A2*1C, CYP1A2*1F and CYP2C19*2 polymorphisms) on each pharmacokinetic parameter...
April 10, 2024: Basic & Clinical Pharmacology & Toxicology
#18
JOURNAL ARTICLE
Man Yin, Xiaohong Tong, Jinyu Yang, Yichen Cheng, Panpan Zhou, Guan Li, Yifeng Wang, Jiezheng Ying
Grain yield in rice is a complex trait and it is controlled by a number of quantitative trait loci (QTL). To dissect the genetic basis of rice yield, QTL analysis for nine yield traits was performed using an F2 population containing 190 plants, which was developed from a cross between Youyidao (YYD) and Sanfenhe (SFH), and each plant in the population evaluated with respect to nine yield traits. In this study, the correlations among the nine yield traits were analyzed. The grain yield per plant positively correlated with six yield traits, except for grain length and grain width, and showed the highest correlation coefficient of 0...
March 8, 2024: Plants (Basel, Switzerland)
#19
JOURNAL ARTICLE
Zinat Sharmin, Hani Samarah, Rafael Aldaya Bourricaudy, Laura Ochoa, Laura Renee Serbus
INTRODUCTION: Endosymbiotic Wolbachia bacteria are widespread in nature, present in half of all insect species. The success of Wolbachia is supported by a commensal lifestyle. Unlike bacterial pathogens that overreplicate and harm host cells, Wolbachia infections have a relatively innocuous intracellular lifestyle. This raises important questions about how Wolbachia infection is regulated. Little is known about how Wolbachia abundance is controlled at an organismal scale. METHODS: This study demonstrates methodology for rigorous identification of cellular processes that affect whole-body Wolbachia abundance, as indicated by absolute counts of the Wolbachia surface protein ( wsp ) gene...
2024: Frontiers in Microbiology
#20
JOURNAL ARTICLE
Nemanja Koljančić, Larissa Onça, Liudmyla Khvalbota, Olga Vyviurska, Adriano A Gomes, Ivan Špánik
This study integrates genetic algorithm (GA) with partial least squares regression (PLSR) and various variable selection methods to identify impactful regions of interest (ROI) in heterogeneous 2D chromatogram images for predicting wine age. As wine quality and aroma evolve over time, transitioning from youthful fruitiness to mature, complex flavors, which leads to alterations in the composition of essential aroma-contributing compounds. Chromatograms are segmented into subimages, and the GA-PLSR algorithm optimizes combinations based on grayscale, red-green-blue (RGB), and hue-saturation-value (HSV) histograms...
2024: Current research in food science
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