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https://www.readbyqxmd.com/read/29351337/a-portable-prototype-magnetometer-to-differentiate-ischemic-and-non-ischemic-heart-disease-in-patients-with-chest-pain
#1
Shima Ghasemi-Roudsari, Abbas Al-Shimary, Benjamin Varcoe, Rowena Byrom, Lorraine Kearney, Mark Kearney
BACKGROUND: Magnetocardiography (MCG) is a non-invasive technique used to measure and map cardiac magnetic fields. We describe the predictive performance of a portable prototype magnetometer designed for use in acute and routine clinical settings. We assessed the predictive ability of the measurements derived from the magnetometer for the ruling-out of healthy subjects and patients whose chest pain has a non-ischemic origin from those with ischemic heart disease (IHD). METHODS: MCG data were analyzed from a technical performance study, a pilot clinical study, and a young healthy reference group...
2018: PloS One
https://www.readbyqxmd.com/read/29349517/a-novel-genomic-signature-predicting-fdg-uptake-in-diverse-metastatic-tumors
#2
Aurora Crespo-Jara, Maria Carmen Redal-Peña, Elena Maria Martinez-Navarro, Manuel Sureda, Francisco Jose Fernandez-Morejon, Francisco J Garcia-Cases, Ramon Gonzalez Manzano, Antonio Brugarolas
BACKGROUND: Building a universal genomic signature predicting the intensity of FDG uptake in diverse metastatic tumors may allow us to understand better the biological processes underlying this phenomenon and their requirements of glucose uptake. METHODS: A balanced training set (n = 71) of metastatic tumors including some of the most frequent histologies, with matched PET/CT quantification measurements and whole human genome gene expression microarrays, was used to build the signature...
January 18, 2018: EJNMMI Research
https://www.readbyqxmd.com/read/29349204/validity-of-a-scale-of-neighbourhood-informal-social-control-relevant-to-pre-schoolers-physical-activity-a-cross-sectional-study
#3
Ester Cerin, Yi Nam Suen, Anthony Barnett, Wendy Y J Huang, Robin R Mellecker
Childhood physical activity (PA) is important for health across the lifespan. Time pre-schoolers spend outdoors, which has been associated with more PA, is likely influenced by parents' perception of neighbourhood informal social control relevant to pre-schoolers' PA, defined as the willingness of neighbours to intervene to ensure social order and a safe community environment for young children's active play. To advance measurement of this construct, we assessed factorial and construct validities of the PA-related neighbourhood informal social control scale for parents of pre-schoolers (PANISC-PP)...
December 2017: SSM—Population Health
https://www.readbyqxmd.com/read/29349094/upper-extremity-functional-status-of-female-youth-softball-pitchers-using-the-kerlan-jobe-orthopaedic-clinic-questionnaire
#4
Kaila A Holtz, Russell J O'Connor
Background: Softball is a popular sport with a high incidence of upper extremity injuries. The Kerlan-Jobe Orthopaedic Clinic (KJOC) questionnaire is a validated performance and functional assessment tool used in overhead athletes. Upper extremity pain patterns and baseline KJOC scores have not been reported for active female youth softball pitchers. Purpose/Hypothesis: The purpose of this study was to establish the prevalence of upper extremity pain and its effect in female youth softball pitchers over a competitive season...
January 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29348925/volume-estimates-in-chronic-hemodialysis-patients-by-the-watson-equation-and-bioimpedance-spectroscopy-and-the-impact-on-the-kt-vurea-calculation
#5
Nazanin Noori, Ron Wald, Arti Sharma Parpia, Marc B Goldstein
Background: Accurate assessment of total body water (TBW) is essential for the evaluation of dialysis adequacy (Kt/Vurea). The Watson formula, which is recommended for the calculation of TBW, was derived in healthy volunteers thereby leading to potentially inaccurate TBW estimates in maintenance hemodialysis recipients. Bioimpedance spectroscopy (BIS) may be a robust alternative for the measurement of TBW in hemodialysis recipients. Objectives: The primary objective of this study was to evaluate the accuracy of Watson formula-derived TBW estimates as compared with TBW measured with BIS...
2018: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/29348810/structure-based-virtual-screening-for-the-discovery-of-novel-inhibitors-of-new-delhi-metallo-%C3%AE-lactamase-1
#6
Francesca Spyrakis, Giuseppe Celenza, Francesca Marcoccia, Matteo Santucci, Simon Cross, Pierangelo Bellio, Laura Cendron, Mariagrazia Perilli, Donatella Tondi
Bacterial resistance has become a worldwide concern after the emergence of metallo-β-lactamases (MBLs). They represent one of the major mechanisms of bacterial resistance against beta-lactam antibiotics. Among MBLs, New Delhi metallo-β-lactamase-1 NDM-1, the most prevalent type, is extremely efficient in inactivating nearly all-available antibiotics including last resort carbapenems. No inhibitors for NDM-1 are currently available in therapy, making the spread of NDM-1 producing bacterial strains a serious menace...
January 11, 2018: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29348595/on-the-angular-distribution-of-the-h-li2-cross-sections-a-converged-time-independent-quantum-scattering-study
#7
Henrique Vieira Rivera Vila, Luiz Antônio Ribeiro, Luiz Guilherme Machado de Macedo, Ricardo Gargano
A thorough time-independent quantum scattering study is performed on a benchmark potential energy surface for the H+Li2 reaction at the fundamental electronic state. Integral and differential cross sections are calculated along with thermal rate coefficients until convergence is reached. Our findings show that vibrational and rotational excitations of the reactant hinder reactivity, though for the latter a considerable reaction promotion was spotted as we increase the reactant rotational quantum number until the critical value of j = 4...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29348552/tpglda-novel-prediction-of-associations-between-lncrnas-and-diseases-via-lncrna-disease-gene-tripartite-graph
#8
Liang Ding, Minghui Wang, Dongdong Sun, Ao Li
Accumulating evidences have indicated that lncRNAs play an important role in various human complex diseases. However, known disease-related lncRNAs are still comparatively small in number, and experimental identification is time-consuming and labor-intensive. Therefore, developing a useful computational method for inferring potential associations between lncRNAs and diseases has become a hot topic, which can significantly help people to explore complex human diseases at the molecular level and effectively advance the quality of disease diagnostics, therapy, prognosis and prevention...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29348406/active-state-organization-of-spontaneous-behavioral-patterns
#9
C Hillar, G Onnis, D Rhea, L Tecott
We report the development and validation of a principled analytical approach to reveal the manner in which diverse mouse home cage behaviors are organized. We define and automate detection of two mutually-exclusive low-dimensional spatiotemporal units of behavior: "Active" and "Inactive" States. Analyses of these features using a large multimodal 16-strain behavioral dataset provide a series of novel insights into how feeding, drinking, and movement behaviors are coordinately expressed in Mus Musculus. Moreover, we find that patterns of Active State expression are exquisitely sensitive to strain, and classical supervised machine learning incorporating these features provides 99% cross-validated accuracy in genotyping animals using behavioral data alone...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29347784/parametric-pulse-amplification-by-acoustic-quasimodes-in-electron-positron-plasma
#10
F Schluck, G Lehmann, K H Spatschek
In a recent paper, M. R. Edwards, N. J. Fisch, and J. M. Mikhailova [Phys. Rev. Lett. 116, 015004 (2016)PRLTAO0031-900710.1103/PhysRevLett.116.015004] reported that in electron-positron plasma stimulated Brillouin scattering is drastically enhanced, while stimulated Raman scattering is completely absent. However, when theory was compared to particle-in-cell (PIC) simulations, a discrepancy by at least a factor four appeared. Authors correctly argued that the disparity might be due to the fluid approximation of the low-frequency mode...
November 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347586/bak-tang-wiesenfeld-model-in-the-upper-critical-dimension-induced-criticality-in-lower-dimensional-subsystems
#11
H Dashti-Naserabadi, M N Najafi
We present extensive numerical simulations of Bak-Tang-Wiesenfeld (BTW) sandpile model on the hypercubic lattice in the upper critical dimension D_{u}=4. After re-extracting the critical exponents of avalanches, we concentrate on the three- and two-dimensional (2D) cross sections seeking for the induced criticality which are reflected in the geometrical and local exponents. Various features of finite-size scaling (FSS) theory have been tested and confirmed for all dimensions. The hyperscaling relations between the exponents of the distribution functions and the fractal dimensions are shown to be valid for all dimensions...
October 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347408/instabilities-in-rapid-directional-solidification-under-weak-flow
#12
Katarzyna N Kowal, Stephen H Davis, Peter W Voorhees
We examine a rapidly solidifying binary alloy under directional solidification with nonequilibrium interfacial thermodynamics viz. the segregation coefficient and the liquidus slope are speed dependent and attachment-kinetic effects are present. Both of these effects alone give rise to (steady) cellular instabilities, mode S, and a pulsatile instability, mode P. We examine how weak imposed boundary-layer flow of magnitude |V| affects these instabilities. For small |V|, mode S becomes a traveling and the flow stabilizes (destabilizes) the interface for small (large) surface energies...
December 2017: Physical Review. E
https://www.readbyqxmd.com/read/29346881/coda-reconstruction-from-cross-correlation-of-a-diffuse-field-on-thin-elastic-plates
#13
Aida Hejazi Nooghabi, Lapo Boschi, Philippe Roux, Julien de Rosny
This study contributes to the evaluation of the robustness and accuracy of Green's function reconstruction from cross-correlation of strongly dispersed reverberated signals, with disentangling of the respective roles of ballistic and reverberated ("coda") contributions. We conduct a suite of experiments on a highly reverberating thin duralumin plate, where an approximately diffuse flexural wave field is generated by taking advantage of the plate reverberation and wave dispersion. A large number of impulsive sources that cover the whole surface of the plate are used to validate ambient-noise theory through comparison of the causal and anticausal (i...
September 2017: Physical Review. E
https://www.readbyqxmd.com/read/29346452/body-shape-indices-are-predictors-for-estimating-fat-free-mass-in-male-athletes
#14
Yohei Takai, Miyuki Nakatani, Toru Aoki, Daisuke Komori, Kazuyuki Oyamada, Kensuke Murata, Eiji Fujita, Takuya Akamine, Yoshihisa Urita, Masayoshi Yamamoto, Hiroaki Kanehisa
It is unknown whether body size and body shape parameters can be predictors for estimating whole body fat-free mass (FFM) in male athletes. This study aimed to investigate whether body size and shape variables can be predictors for FFM in male athletes. Using a whole-body dual-energy X-ray absorptiometry scanner, whole body fat mass (FM) and FFM were determined in 132 male athletes and 14 sedentary males. The sample was divided into two groups: validation (N = 98) and cross-validation (N = 48) groups. Body height (BH), body mass (BM), and waist circumference at immediately above the iliac crest (W) were measured...
2018: PloS One
https://www.readbyqxmd.com/read/29345859/development-of-a-risk-prediction-model-for-lung-cancer-the-japan-public-health-center-based-prospective-study
#15
Hadrien Charvat, Shizuka Sasazuki, Taichi Shimazu, Sanjeev Budhathoki, Manami Inoue, Motoki Iwasaki, Norie Sawada, Taiki Yamaji, Shoichiro Tsugane
While the impact of tobacco consumption on the occurrence of lung cancer is well-established, risk estimation could be improved by risk prediction models that consider various smoking habits, such as quantity, duration, and time since quitting. We constructed a risk prediction model using a population of 59,161 individuals from JPHC Study Cohort II. A parametric survival model was used to assess the impact of age, gender and smoking-related factors (cumulative smoking intensity measured in pack-years, age at initiation, and time since cessation)...
January 18, 2018: Cancer Science
https://www.readbyqxmd.com/read/29345744/land-surveys-show-regional-variability-of-historical-fire-regimes-and-structure-of-dry-forests-of-the-western-usa
#16
William L Baker, Mark A Williams
An understanding of how historical fire and structure in dry forests (ponderosa pine, dry mixed conifer) varied across the western USA remains incomplete. Yet, fire strongly affects ecosystem services, and forest restoration programs are underway. We used General Land Office survey reconstructions from the late-1800s across 11 landscapes covering ∼1.9 million ha in four states to analyze spatial variation in fire regimes and forest structure. We first synthesized the state of validation of our methods using 20 modern validations, 53 historical cross-validations, and corroborating evidence...
January 18, 2018: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/29345192/cross-validation-of-the-dot-counting-test-in-a-large-sample-of-credible-and-non-credible-patients-referred-for-neuropsychological-testing
#17
Courtney McCaul, Kyle B Boone, Annette Ermshar, Maria Cottingham, Tara L Victor, Elizabeth Ziegler, Michelle A Zeller, Matthew Wright
OBJECTIVE: To cross-validate the Dot Counting Test in a large neuropsychological sample. METHOD: Dot Counting Test scores were compared in credible (n = 142) and non-credible (n = 335) neuropsychology referrals. RESULTS: Non-credible patients scored significantly higher than credible patients on all Dot Counting Test scores. While the original E-score cut-off of ≥17 achieved excellent specificity (96.5%), it was associated with mediocre sensitivity (52...
January 18, 2018: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/29345073/improving-accuracy-of-genomic-prediction-in-brangus-cattle-by-adding-animals-with-imputed-low-density-snp-genotypes
#18
F B Lopes, X-L Wu, H Li, J Xu, T Perkins, J Genho, R Ferretti, R G Tait, S Bauck, G J M Rosa
Reliable genomic prediction of breeding values for quantitative traits requires the availability of sufficient number of animals with genotypes and phenotypes in the training set. As of 31 October 2016, there were 3,797 Brangus animals with genotypes and phenotypes. These Brangus animals were genotyped using different commercial SNP chips. Of them, the largest group consisted of 1,535 animals genotyped by the GGP-LDV4 SNP chip. The remaining 2,262 genotypes were imputed to the SNP content of the GGP-LDV4 chip, so that the number of animals available for training the genomic prediction models was more than doubled...
February 2018: Journal of Animal Breeding and Genetics, Zeitschrift Für Tierzüchtung und Züchtungsbiologie
https://www.readbyqxmd.com/read/29344696/reconstruction-of-the-medial-patellotibial-ligament-results-in-favorable-clinical-outcomes-a-systematic-review
#19
Charles A Baumann, Eli L Pratte, Seth L Sherman, Elizabeth A Arendt, Betina B Hinckel
PURPOSE: The medial patellotibial ligament (MPTL), the medial patellofemoral ligament (MPFL), and the medial patellomeniscal ligament (MPML) support the stability of the patellofemoral joint. The purpose of this systematic review was to report the surgical techniques and clinical outcomes of the repair or reconstruction of the MPTL in isolation or concomitant with the MPFL and/or other procedures. METHODS: A systematic review of the literature was conducted. Inclusion criteria were articles in the English language that reported clinical outcomes of the reconstruction of the MPTL in isolation or in combination with the MPFL and/or other procedures...
January 17, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29344525/psychometric-properties-of-the-communication-skills-attitude-scale-csas-measure-in-a-sample-of-iranian-medical-students
#20
Afsaneh Yakhforoshha, Mandana Shirazi, Naser Yousefzadeh, Amin Ghanbarnejad, Mohammadali Cheraghi, Rita Mojtahedzadeh, Behrooz Mahmoodi-Bakhtiari, Seyed Amir Hossein Emami
Introduction: Communication skill (CS) has been regarded as one of the fundamental competencies for medical and other health care professionals. Student's attitude toward learning CS is a key factor in designing educational interventions. The original CSAS, as positive and negative subscales, was developed in the UK; however, there is no scale to measure these attitudes in Iran. The aim of this study was to assess the psychometric characteristic of the Communication Skills Attitude Scale (CSAS), in an Iranian context and to understand if it is a valid tool to assess attitude toward learning communication skills among health care professionals...
January 2018: Journal of Advances in Medical Education & Professionalism
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