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https://www.readbyqxmd.com/read/28817734/treatment-gap-and-barriers-for-mental-health-care-a-cross-sectional-community-survey-in-nepal
#1
Nagendra P Luitel, Mark J D Jordans, Brandon A Kohrt, Sujit D Rathod, Ivan H Komproe
CONTEXT: There is limited research on the gap between the burden of mental disorders and treatment use in low- and middle-income countries. OBJECTIVES: The aim of this study was to assess the treatment gap among adults with depressive disorder (DD) and alcohol use disorder (AUD) and to examine possible barriers to initiation and continuation of mental health treatment in Nepal. METHODS: A three-stage sampling technique was used in the study to select 1,983 adults from 10 Village Development Committees (VDCs) of Chitwan district...
2017: PloS One
https://www.readbyqxmd.com/read/28817645/translation-cultural-adaptation-and-validation-of-simplified-chinese-version-of-the-anterior-cruciate-ligament-return-to-sport-after-injury-acl-rsi-scale
#2
Tianwu Chen, Peng Zhang, Yunxia Li, Kate Webster, Jian Zhang, Wei Yao, Yue Yin, Chingchong Ai, Shiyi Chen
PURPOSE: To translate and cross-culturally adapt the anterior cruciate ligament-return to sport after injury (ACL-RSI) into simplified Chinese [ACL-RSI (Cn)]. METHOD: In this diagnostic study, the translation, cross-culturally adaptation, and validation of the ACL-RSI was performed according to international guidelines. A total of 112 patients with ACL reconstruction participated in this study. All were capable of competitive sports before the injury and completed the Knee Injury and Osteoarthritis Outcome (KOOS), the International Knee Documentation Committee (IKDC), the Tampa Scale of Kinesiophobia (TSK), and the Tegner activity score...
2017: PloS One
https://www.readbyqxmd.com/read/28816956/differential-diagnosis-of-posterior-fossa-brain-tumors-multiple-discriminant-analysis-of-tl-spect-and-fdg-pet
#3
Moritaka Yamauchi, Tomohisa Okada, Tsutomu Okada, Akira Yamamoto, Yasutaka Fushimi, Yoshiki Arakawa, Susumu Miyamoto, Kaori Togashi
This study investigated the combined capability of thallium-201 (Tl)-SPECT and fluorine-18-fluoro-deoxy-glucose (FDG)-PET for differential diagnosis of posterior fossa brain tumors using multiple discriminant analysis.This retrospective study was conducted under approval of the institutional review board. In the hospital information system, 27 patients with posterior fossa intra-axial tumor between January 2009 and June 2015 were enrolled and grouped as the following 7 entities: low grade glioma (LGG) 6, anaplastic astrocytoma (AA) 2, glioblastoma (GBM) 3, medulloblastoma (MB) 3, hemangioblastoma (HB) 6, metastatic tumor (Mets) 3, and malignant lymphoma (ML) 4...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28816770/prevalence-of-disability-in-patients-with-musculoskeletal-pain-and-rheumatic-diseases-in-a-population-from-cuenca-ecuador
#4
Sergio Vicente Guevara-Pacheco, Astrid Feican-Alvarado, Jorge Delgado-Pauta, Angelita Lliguisaca-Segarra, Ingris Pelaez-Ballestas
OBJECTIVE: The aim of this study was to determine the prevalence of disability in patients with musculoskeletal pain and rheumatic diseases in Cuenca, Ecuador. METHODS: We performed a cross-sectional analytical study with randomized sampling in 4877 subjects, from urban and rural areas. COPCORD (Community Oriented Program for Control of Rheumatic Diseases)-validated questionnaire was administered house-to-house to identify subjects with nontraumatic musculoskeletal pain and rheumatic diseases...
August 14, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28816668/fast-open-world-person-re-identification
#5
Xiatian Zhu, Botong Wu, Dongcheng Huang, Wei-Shi Zheng
Existing person re-identification (re-id) methods typically assume that (1) any probe person is guaranteed to appear in the gallery target population during deployment (i.e. closed-world), and (2) the probe set contains only a limited number of people (i.e. small search scale). Both assumptions are artificial and breached in real-world applications, since the probe population in target people search can be extremely vast in practice due to the ambiguity of probe search space boundary. Therefore, it is unrealistic that any probe person is assumed as one target people, and a large-scale search in person images is inherently demanded...
August 16, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28816575/cross-cultural-translation-validity-and-reliability-of-the-french-version-of-the-neurophysiology-of-pain-questionnaire
#6
Christophe Demoulin, Pauline Brasseur, Nathalie Roussel, Clara Brereton, Fabienne Humblet, Daniel Flynn, Julien Van Beveren, Thomas Osinsky, Anne-Françoise Donneau, Jean-Michel Crielaard, Marc Vanderthommen, Olivier Bruyère
Pain physiology education is an important component in the management of patients with chronic musculoskeletal pain. The Neurophysiology of Pain Questionnaire (NPQ) was developed in English to assess pain physiology knowledge in patients. This study aimed to translate the NPQ into French (NPQ-Fr) and to investigate the main psychometric properties of the NPQ-Fr. The translation was performed using the best practice translation guidelines. One hundred and one French-speaking patients with chronic non-specific spinal pain completed the NPQ-Fr to assess its acceptability and presence of floor/ceiling effects and test its dimensionality...
August 17, 2017: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/28816417/docking-field-based-qsar-and-pharmacophore-studies-on-the-substituted-pyrimidine-derivatives-targeting-hiv-1-reverse-transcriptase
#7
Ningning Fan, Shuang Zhang, Tao Sheng, Liang Zhao, Zhenming Liu, Junyi Liu, Xiaowei Wang
HIV-1 reverse transcriptase (RT) is one of the most important enzymes required for viral replication, thus acting as an attractive target for anti-retroviral therapy. Pyrimidine analogues reportedly have selective inhibition on HIV-1 RT with favorable antiviral activities in our previous study. To further explore the relationship between inhibitory activity and pharmacophoric characteristics, field-based QSAR models were generated and validated using Schrodinger Suite (correlation coefficient of 0.8078, cross-validated value of 0...
August 17, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28816338/prediction-of-emergency-department-hospital-admission-based-on-natural-language-processing-and-neural-networks
#8
Xingyu Zhang, Joyce Kim, Rachel E Patzer, Stephen R Pitts, Aaron Patzer, Justin D Schrager
OBJECTIVE: To describe and compare logistic regression and neural network modeling strategies to predict hospital admission or transfer following initial presentation to Emergency Department (ED) triage with and without the addition of natural language processing elements. METHODS: Using data from the National Hospital Ambulatory Medical Care Survey (NHAMCS), a cross-sectional probability sample of United States EDs from 2012 and 2013 survey years, we developed several predictive models with the outcome being admission to the hospital or transfer vs...
August 16, 2017: Methods of Information in Medicine
https://www.readbyqxmd.com/read/28816075/psychological-impact-of-female-genital-mutilation-among-adolescent-egyptian-girls-a-cross-sectional-study
#9
Magdy R Ahmed, Mohamed M Shaaban, Heba K Meky, Mohamed E Amin Arafa, Tamer Y Mohamed, Waleed F Gharib, Abeer B Ahmed
OBJECTIVES: Worldwide, at least 200 million women and girls have undergone female genital mutilation (FGM). The medical and sexual consequences have been documented, but the psychological impact has not been studied to the same extent. The aim of this study was to explore the relationship between FGM and psychiatric problems among adolescent girls. METHODS: A total of 204 girls, aged 14-19 years, were included in a cross-sectional study conducted at Suez Canal University Hospitals...
August 17, 2017: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/28815878/prediction-of-energy-expenditure-during-walking-in-adults-with-down-syndrome
#10
Stamatis Agiovlasitis, Goncalo V Mendonca, Jeffrey A McCubbin, Bo Fernhall
BACKGROUND: When developing walking programmes for improving health in adults with Down syndrome (DS), physical activity professionals are in need of an equation for predicting energy expenditure. We therefore developed and cross-validated an equation for predicting the rate of oxygen uptake (VO2 ; an index of energy expenditure) for adults with and without DS. METHOD: A total of 469 VO2 observations during walking across different speeds were available from 54 adults with DS and 61 adults without DS...
August 16, 2017: Journal of Applied Research in Intellectual Disabilities: JARID
https://www.readbyqxmd.com/read/28815856/molecular-dynamics-insights-into-polyamine-dna-binding-modes-implications-for-cross-link-selectivity
#11
Emmanuelle Bignon, Chen-Hui Chan, Christophe Morell, Antonio Monari, Jean-Luc Ravanat, Elise Dumont
Biogenic polyamines, which play a role in DNA condensation and stabilization, are ubiquitous and are found at millimolar concentration in the nucleus of eukaryotic cells. The interaction modes of three polyamines-putrescine (Put), spermine (Spm), and spermidine (Spd)-with a self-complementary 16 base pair (bp) duplex, are investigated by all-atom explicit-solvent molecular dynamics. The length of the amine aliphatic chain leads to a change of the interaction mode from minor groove binding to major groove binding...
August 16, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28815033/early-histological-findings-may-predict-the-clinical-phenotype-in-crohn-s-colitis
#12
Amir Klein, Yoav Mazor, Amir Karban, Ofer Ben-Itzhak, Yehuda Chowers, Edmond Sabo
BACKGROUND AND AIMS: Predicting the clinical course of Crohn's disease (CD) is relevant for treatment selection. Currently, such diagnostic tools are lacking. In a previous pilot study, morphometric tissue image analysis showed promise in predicting the clinical phenotype and need for surgery. In this study, we aimed to validate our previous results on a larger cohort. METHODS: Colonic biopsies from CD patients with colonic or ileocolonic disease and at least five years of post-biopsy clinical follow-up were analyzed...
August 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28814842/bfh-ostm-a-new-predictive-screening-tool-for-identifying-osteoporosis-in-elderly-han-chinese-males
#13
JiSheng Lin, Yong Yang, XiaoDong Zhang, Zhao Ma, Hao Wu, Yongjin Li, Xiuquan Yang, Qi Fei, Ai Guo
PURPOSE: To develop and validate a new clinical screening tool to identify primary osteoporosis by dual-energy X-ray absorptiometry (DXA) in two elderly Han Chinese male populations. METHODS: A cross-sectional study was conducted, enrolling 1,870 community-dwelling and 574 hospital-checkup elderly Han Chinese males aged ≥50 years. All subjects completed a structured questionnaire and had their bone mineral density (BMD) measured using DXA. Using logistic regression analysis in the 1,870 community-dwelling males, we assessed the ability of numerous potential clinical risk factors to identify male with osteoporosis...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28814731/spatial-regression-and-prediction-of-water-quality-in-a-watershed-with-complex-pollution-sources
#14
Xiaoying Yang, Qun Liu, Xingzhang Luo, Zheng Zheng
Fast economic development, burgeoning population growth, and rapid urbanization have led to complex pollution sources contributing to water quality deterioration simultaneously in many developing countries including China. This paper explored the use of spatial regression to evaluate the impacts of watershed characteristics on ambient total nitrogen (TN) concentration in a heavily polluted watershed and make predictions across the region. Regression results have confirmed the substantial impact on TN concentration by a variety of point and non-point pollution sources...
August 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28814586/molecular-diagnosis-of-invasive-aspergillosis-and-detection-of-azole-resistance-by-a-newly-commercialized-pcr-kit
#15
Eric Dannaoui, Frédéric Gabriel, Manuel Gaboyard, Gaëlle Lagardere, Lucile Audebert, Gilles Quesne, Sandrine Godichaud, Paul E Verweij, Isabelle Accoceberry, Marie-Elisabeth Bougnoux
Aspergillus fumigatus is the main species responsible for aspergillosis in humans. The diagnosis of aspergillosis remains difficult, and the rapid emergence of azole resistance in A. fumigatus, is worrisome. The aim of this study was to validate the new MycoGENIE® A. fumigatus real-time PCR kit and to evaluate its performance in clinical samples for the detection of A. fumigatus and its azole resistance. This multiplex assay detects DNA from the A. fumigatus species complex by targeting the 28S-rRNA multicopy gene and specific TR34 and L98H mutations in the cyp51A single copy gene of A...
August 16, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28814505/the-molecular-architecture-of-the-yeast-spindle-pole-body-core-determined-by-bayesian-integrative-modeling
#16
Shruthi Viswanath, Massimiliano Bonomi, Seung Joong Kim, Vadim A Klenchin, Keenan C Taylor, King C Yabut, Neil T Umbreit, Heather A Van Epps, Janet Meehl, Michele H Jones, Daniel Russel, Javier A Velazquez-Muriel, Mark Winey, Ivan Rayment, Trisha N Davis, Andrej Sali, Eric G Muller
Microtubule organizing centers (MTOCs) form, anchor and stabilize the polarized network of microtubules in a cell. The central MTOC is the centrosome that duplicates during the cell cycle and during mitosis assembles a bipolar spindle to capture and segregate sister chromatids. Yet, despite their importance in cell biology, the physical structure of MTOCs is poorly understood. Here we determine the molecular architecture of the core of the yeast spindle pole body (SPB) by Bayesian integrative structure modeling based on in vivo FRET, small-angle X-ray scattering (SAXS), X-ray crystallography, electron microscopy and two-hybrid analysis...
August 16, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28814114/cross-cultural-validation-of-the-falls-efficacy-scale-international-to-assess-concerns-about-falls-among-hungarian-community-living-older-people
#17
Éva Kovács, Franciska Rozs, Anna Petridisz, Réka Erdős, Eszter Majercsik
PURPOSE: The Falls Efficacy Scale-International (FES-I) is a reliable and valid tool for assessing concerns about falling. Our aims were to translate, culturally adapt, and evaluate the main psychometric characteristics (internal consistency, reproducibility, and convergent construct validity) of the Hungarian version of the FES-I on a sample of community-living older adults. METHODS: After translating and culturally adapting the original scale, 165 community-living older adults (aged 60 years or over) participated in the measurements and filled in the questionnaire...
August 17, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28814104/factors-associated-with-low-neighborhood-cohesion-among-women-living-with-hiv-impacted-by-social-structural-inequities-in-british-columbia
#18
Kalysha Closson, Alexis K Palmer, Alexandra B Collins, Kate Salters, Wendy Zhang, Julio S G Montaner, Robert S Hogg, Surita Parashar
Built and social environments, including one's perception of their environment, are important determinants of health. The intersection of gender and HIV status may complicate the role of neighborhood cohesion in safety, personal well-being, and health outcomes for populations impacted by social and structural inequities. Among women in particular, social cohesion within the neighborhood they reside in may have a greater influence on health outcomes compared to their male counterparts. We sought to examine perception of neighborhood cohesion (validated scale with a range 0-100, with higher scores indicating higher perceived neighborhood cohesion) among women living with HIV, impacted by social-structural inequities, receiving combination antiretroviral therapy, and enrolled in the Longitudinal Investigations into Supportive Ancillary health services (LISA) study in British Columbia, Canada...
August 17, 2017: AIDS Care
https://www.readbyqxmd.com/read/28813854/automated-stand-up-and-sit-down-detection-for-robot-assisted-body-weight-support-training-with-the-float
#19
Mathias Bannwart, Dominique Emst, Chris Easthope, Marc Bolliger, Georg Rauter
Patients with impaired walking function are often dependent on assistive devices to retrain gait and regain independence in life. To provide adequate support, gait rehabilitation devices have to be manually set to the correct support mode or have to recognize the type and starting point of a certain motion automatically. For automated motion type detection, machine learning-based classification algorithms using sensor signals from different body parts can achieve robust performance. However, until today, there is only little work available to detect motion onset...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813806/design-of-continuous-emg-classification-approaches-towards-the-control-of-a-robotic-exoskeleton-in-reaching-movements
#20
Nerea Irastorza-Landa, Andrea Sarasola-Sanz, Eduardo Lopez-Larraz, Carlos Bibian, Parid Shiman, Niels Birbaumer, Ander Ramos-Murguialday
Myoelectric control of rehabilitation devices engages active recruitment of muscles for motor task accomplishment, which has been proven to be essential in motor rehabilitation. Unfortunately, most electromyographic (EMG) activity-based controls are limited to one single degree-of-freedom (DoF), not permitting multi-joint functional tasks. On the other hand, discrete EMG-triggered approaches fail to provide continuous feedback about muscle recruitment during movement. For such purposes, myoelectric interfaces for continuous recognition of functional movements are necessary...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
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