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https://www.readbyqxmd.com/read/28735303/acid-fast-bacterium-detection-and-identification-from-paraffin-embedded-tissues-using-a-pcr-pyrosequencing-method
#1
Jian R Bao, Richard B Clark, Ronald N Master, Kileen L Shier, Lynn L Eklund
AIMS: Acid-fast bacterium (AFB) identification from formalin-fixed paraffin-embedded (FFPE) tissues is challenging and may not be readily available to the clinical laboratory. A method to detect and identify AFB from FFPE tissues using PCR and pyrosequencing (PCR-Seq) was developed and evaluated. METHODS: The method was validated using spiked cell-clotted paraffin blocks before use with patients' specimens. DNA was extracted from tissue sections, and a 16S rRNA gene fragment was amplified and a signature sequence was produced on a PyroMark ID system...
July 22, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28735077/opioid-medication-misuse-among-unhealthy-drinkers
#2
Gerald Cochran, Rebecca McCarthy, Adam J Gordon, Ralph E Tarter
BACKGROUND: Combining opioid medications and alcohol has serious implications for patient health, including overdose. Information regarding those who use/misuse opioid medications and engage in unhealthy alcohol use is limited to pharmacological and epidemiological descriptions. This study presents opioid medication misuse and behavioral, mental, and physical health characteristics of persons filling opioid medications that are engaged in unhealthy alcohol use. METHODS: We conducted a cross-sectional survey at 5 community pharmacies in Southwestern, Pennsylvania among patients filling opioid medications...
July 14, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28734987/bioavailable-and-free-25-hydroxyvitamin-d-and-vitamin-d-binding-protein-in-polycystic-ovary-syndrome-relationships-with-obesity-and-insulin-resistance
#3
Negar Naderpoor, Soulmaz Shorakae, Sally K Abell, Aya Mousa, Anju E Joham, Lisa J Moran, Nigel K Stepto, Poli Mara Spritzer, Helena J Teede, Barbora de Courten
Polycystic ovary syndrome (PCOS) is a common condition characterised by both reproductive and metabolic features (obesity, insulin resistance, diabetes risk). Some evidence suggests that women with PCOS have lower vitamin D levels compared to healthy controls. Vitamin D binding protein (DBP) is the main carrier of vitamin D in circulation and plays an important role in regulating vitamin D concentration and bioavailability for target tissues. To our knowledge, no previous studies have examined DBP, bioavailable and free 25-hydroxyvitamin D (25(OH)D) in women with PCOS...
July 19, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28734816/glaucoma-screening-in-nepal-cup-to-disc-estimate-with-standard-mydriatic-fundus-camera-compared-to-portable-non-mydriatic-camera
#4
Sarah E Miller, Suman Thapa, Alan L Robin, Leslie M Niziol, Pradeep Y Ramulu, Maria A Woodward, Indira Paudyal, Ian Pitha, Tyson N Kim, Paula Anne Newman-Casey
PURPOSE: To compare cup to disc ratio (CDR) measurements from images taken with a portable, 45° non-mydriatic fundus camera to images from a traditional table-top mydriatic fundus camera. DESIGN: Prospective, cross sectional, comparative instrument validation study. METHODS: materials-methods SETTING: Clinic-based. STUDY POPULATION: 422 eyes of 211 subjects were recruited from the Tilganga Institute of Ophthalmology (Kathmandu, Nepal)...
July 19, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28734664/ph-responsive-biodegradable-nanogels-for-sustained-release-of-bleomycin
#5
Prashant Sahu, Sushil K Kashaw, Varun Kushwah, Samaresh Sau, Sanyog Jain, Arun K Iyer
Site specific drug delivery with desired therapeutic effect still remains challenging task due to suboptimal release, tissue toxicity, low selectivity and meager therapeutic efficacy in skin cancers. The aim of the current study was to fabricate pH responsive, self-assembled, chemically cross-linked biodegradable chitosan nanogel loaded with bleomycin to target the dermal area of the skin. The nanogel synthesized by ion gelation technique and was characterized for drug loading, swelling and thermal stability followed by in vitro analysis...
June 27, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28734609/reinforcements-in-avian-wing-bones-experiments-analysis-and-modeling
#6
E Novitskaya, C J Ruestes, M M Porter, V A Lubarda, M A Meyers, J McKittrick
Almost all species of modern birds are capable of flight; the mechanical competency of their wings and the rigidity of their skeletal system evolved to enable this outstanding feat. One of the most interesting examples of structural adaptation in birds is the internal structure of their wing bones. In flying birds, bones need to be sufficiently strong and stiff to withstand forces during takeoff, flight, and landing, with a minimum of weight. The cross-sectional morphology and presence of reinforcing structures (struts and ridges) found within bird wing bones vary from species to species, depending on how the wings are utilized...
July 14, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28734576/predictive-validity-analysis-of-six-reference-equations-for-the-6-minute-walk-test-in-healthy-brazilian-men-a-cross-sectional-study
#7
Alexandher Negreiros, Rosimeire Simprini Padula, Rosane Andrea Bretas Bernardes, Mônica Vasconcelos de Moraes, Raquel Simoni Pires, Luciana Dias Chiavegato
BACKGROUND: The six-minute walk test (6MWT) is an important tool for evaluating functional capacity and exercise tolerance. The reference equations for the 6MWT in healthy subjects were established on the basis of American and European populations, but reference equations have been proposed with different variables for the Brazilian population. OBJECTIVE: To analyze the predictive validity of six reference equations for the six-minute walking distance (6MWD) in healthy adult men...
July 4, 2017: Brazilian Journal of Physical Therapy
https://www.readbyqxmd.com/read/28734553/dietary-inflammatory-index-and-liver-status-in-subjects-with-different-adiposity-levels-within-the-predimed-trial
#8
Irene Cantero, Itziar Abete, Nancy Babio, Fernando Arós, Dolores Corella, Ramón Estruch, Montse Fitó, James R Hebert, M Ángel Martínez-González, Xavier Pintó, M Puy Portillo, Miguel Ruiz-Canela, Nitin Shivappa, Julia Wärnberg, Enrique Gómez-Gracia, J Antoni Tur, Jordi Salas-Salvadó, M Angeles Zulet, J Alfredo Martínez
BACKGROUND & AIMS: To assess the possible association between a validated Dietary Inflammatory Index (DII) and specific dietary components with suitable non-invasive markers of liver status in overweight and obese subjects within the PREDIMED study. METHODS: A cross-sectional study encompassing 794 randomized overweight and obese participants (mean ± SD age: 67.0 ± 5.0 y, 55% females) from the PREDIMED (PREvención con DIeta MEDiterránea) trial was conducted...
July 6, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28734530/joint-optic-disc-and-cup-boundary-extraction-from-monocular-fundus-images
#9
Arunava Chakravarty, Jayanthi Sivaswamy
BACKGROUND AND OBJECTIVE: Accurate segmentation of optic disc and cup from monocular color fundus images plays a significant role in the screening and diagnosis of glaucoma. Though optic cup is characterized by the drop in depth from the disc boundary, most existing methods segment the two structures separately and rely only on color and vessel kink based cues due to the lack of explicit depth information in color fundus images. METHODS: We propose a novel boundary-based Conditional Random Field formulation that extracts both the optic disc and cup boundaries in a single optimization step...
August 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28734529/ultrasound-based-differentiation-of-malignant-and-benign-thyroid-nodules-an-extreme-learning-machine-approach
#10
Jianfu Xia, Huiling Chen, Qiang Li, Minda Zhou, Limin Chen, Zhennao Cai, Yang Fang, Hong Zhou
BACKGROUND AND OBJECTIVES: It is important to be able to accurately distinguish between benign and malignant thyroid nodules in order to make appropriate clinical decisions. The purpose of this study was to improve the effectiveness and efficiency for discriminating the malignant from benign thyroid cancers based on the Ultrasonography (US) features. METHODS: There were 114 benign nodules in 106 patients (82 women and 24 men) and 89 malignant nodules in 81 patients (69 women and 12 men) included in this study...
August 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28734525/classification-of-cardiovascular-tissues-using-lbp-based-descriptors-and-a-cascade-svm
#11
Claudia Mazo, Enrique Alegre, Maria Trujillo
BACKGROUND AND OBJECTIVE: Histological images have characteristics, such as texture, shape, colour and spatial structure, that permit the differentiation of each fundamental tissue and organ. Texture is one of the most discriminative features. The automatic classification of tissues and organs based on histology images is an open problem, due to the lack of automatic solutions when treating tissues without pathologies. METHOD: In this paper, we demonstrate that it is possible to automatically classify cardiovascular tissues using texture information and Support Vector Machines (SVM)...
August 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28734364/improved-variable-reduction-in-partial-least-squares-modelling-by-global-minimum-error-uninformative-variable-elimination
#12
Jan P M Andries, Yvan Vander Heyden, Lutgarde M C Buydens
The calibration performance of Partial Least Squares regression (PLS) can be improved by eliminating uninformative variables. For PLS, many variable elimination methods have been developed. One is the Uninformative-Variable Elimination for PLS (UVE-PLS). However, the number of variables retained by UVE-PLS is usually still large. In UVE-PLS, variable elimination is repeated as long as the root mean squared error of cross validation (RMSECV) is decreasing. The set of variables in this first local minimum is retained...
August 22, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28734269/crime-scene-reconstruction-sex-prediction-from-blood-stained-foot-sole-impressions
#13
Nabanita Basu, Samir Kumar Bandyopadhyay
It is often difficult to predict the sex of an individual based on bloody incomplete footprints. However, such prints/impressions are particularly common in a crime scene. Again variability in the texture, color of the target surface has an impact on the bloodstained impression formed. The study of bare foot, footprint, footwear (i.e. shoe, canvas etc.) within the legal context is referred to as forensic podiatry. Based on the fact that it is possible to predict the sex of an individual from footprint impressions, an automated model has been proposed in this paper for analyzing the sex of an individual from his/her broken/incomplete footprint impressions based on morphological features alone...
June 26, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28734237/the-spider-and-the-snake-a-psychometric-study-of-two-phobias-and-insights-from-the-hungarian-validation
#14
Andras N Zsido
Specific phobias-particularly zoophobias-are prevalent worldwide and can have fairly dramatic health consequences. Self-report measurements play a crucial role in phobia research studies; thus, it is important to have a reliable tool in different languages. The present investigation examined the psychometric properties of the Hungarian version of two commonly used measures of fear: the Spider Phobia Questionnaire (i.e. SPQ) and the Snake Questionnaire (i.e. SNAQ). The SPQ and SNAQ scores both demonstrated excellent reliability, including a test-retest over a 4-week period...
July 13, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28734169/development-and-psychometric-validation-of-the-headache-screening-questionnaire-dutch-version
#15
Hedwig A van der Meer, Corine M Visscher, Raoul H H Engelbert, Wim M Mulleners, Maria W G Nijhuis-van der Sanden, Caroline M Speksnijder
BACKGROUND: Headache is a common disorder which may lead to substantial socio-economic loss. Treatment options include self-management strategies, medication and physiotherapy. Physiotherapists need to be able to screen for the presence of migraine and tension-type headache (TTH), so they can adjust their treatment strategies to the type of headache. A quick screening questionnaire to recognize migraine and TTH in the physiotherapy practice is needed. OBJECTIVE: The aim of this study was to create a headache screening questionnaire based on the ICHD-3 beta criteria for migraine and TTH, and to establish its content and criterion validity...
July 4, 2017: Musculoskeletal Science & Practice
https://www.readbyqxmd.com/read/28734115/regularized-estimation-in-sparse-high-dimensional-multivariate-regression-with-application-to-a-dna-methylation-study
#16
Haixiang Zhang, Yinan Zheng, Grace Yoon, Zhou Zhang, Tao Gao, Brian Joyce, Wei Zhang, Joel Schwartz, Pantel Vokonas, Elena Colicino, Andrea Baccarelli, Lifang Hou, Lei Liu
In this article, we consider variable selection for correlated high dimensional DNA methylation markers as multivariate outcomes. A novel weighted square-root LASSO procedure is proposed to estimate the regression coefficient matrix. A key feature of this method is tuning-insensitivity, which greatly simplifies the computation by obviating cross validation for penalty parameter selection. A precision matrix obtained via the constrained ℓ1 minimization method is used to account for the within-subject correlation among multivariate outcomes...
July 26, 2017: Statistical Applications in Genetics and Molecular Biology
https://www.readbyqxmd.com/read/28733927/nut-intake-and-5-year-changes-in-body-weight-and-obesity-risk-in-adults-results-from-the-epic-panacea-study
#17
Heinz Freisling, Hwayoung Noh, Nadia Slimani, Véronique Chajès, Anne M May, Petra H Peeters, Elisabete Weiderpass, Amanda J Cross, Guri Skeie, Mazda Jenab, Francesca R Mancini, Marie-Christine Boutron-Ruault, Guy Fagherazzi, Verena A Katzke, Tilman Kühn, Annika Steffen, Heiner Boeing, Anne Tjønneland, Cecilie Kyrø, Camilla P Hansen, Kim Overvad, Eric J Duell, Daniel Redondo-Sánchez, Pilar Amiano, Carmen Navarro, Aurelio Barricarte, Aurora Perez-Cornago, Konstantinos K Tsilidis, Dagfinn Aune, Heather Ward, Antonia Trichopoulou, Androniki Naska, Philippos Orfanos, Giovanna Masala, Claudia Agnoli, Franco Berrino, Rosario Tumino, Carlotta Sacerdote, Amalia Mattiello, H Bas Bueno-de-Mesquita, Ulrika Ericson, Emily Sonestedt, Anna Winkvist, Tonje Braaten, Isabelle Romieu, Joan Sabaté
PURPOSE: There is inconsistent evidence regarding the relationship between higher intake of nuts, being an energy-dense food, and weight gain. We investigated the relationship between nut intake and changes in weight over 5 years. METHODS: This study includes 373,293 men and women, 25-70 years old, recruited between 1992 and 2000 from 10 European countries in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Habitual intake of nuts including peanuts, together defined as nut intake, was estimated from country-specific validated dietary questionnaires...
July 21, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28733298/are-there-patient-related-factors-that-influence-sickness-certification-in-patients-with-severe-subjective-health-complaints-a-cross-sectional-exploratory-study-from-different-european-countries
#18
Suzanne L Merkus, Rob Hoedeman, Silje Mæland, Kristel H N Weerdesteijn, Frederieke G Schaafsma, Maud Jourdain, Jean-Paul Canevet, Cédric Rat, Johannes R Anema, Erik L Werner
OBJECTIVES: To develop hypotheses about whether there are patient-related factors that influence physicians' decision-making that can explain why some patients with severe subjective health complaints (SHCs) are more likely to be granted sick leave than others. DESIGN: Exploratory cross-sectional. SETTING: Assessments of patient-related factors after watching nine authentic video recordings of patients with severe SHC from a Norwegian general practice...
July 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/28733087/unobtrusive-assessment-of-neonatal-sleep-state-based-on-heart-rate-variability-retrieved-from-electrocardiography-used-for-regular-patient-monitoring
#19
Jan Werth, Xi Long, Elly Zwartkruis-Pelgrim, Hendrik Niemarkt, Wei Chen, Ronald M Aarts, Peter Andriessen
As an approach of unobtrusive assessment of neonatal sleep state we aimed at an automated sleep state coding based only on heart rate variability obtained from electrocardiography used for regular patient monitoring. We analyzed active and quiet sleep states of preterm infants between 30 and 37weeks postmenstrual age. To determine the sleep states we used a nonlinear kernel support vector machine for sleep state separation based on known heart rate variability features. We used unweighted and weighted misclassification penalties for the imbalanced distribution between sleep states...
July 18, 2017: Early Human Development
https://www.readbyqxmd.com/read/28732942/decomposition-of-ppcps-by-ultrasound-assisted-advanced-fenton-reaction-a-case-study-with-salicylic-acid
#20
Başak Savun-Hekimoğlu, Nilsun H Ince
The study is about the degradation of a widely used pharmaceutical and personal care product-salicylic acid by sonocatalysis, and the experimental design of the reaction system. The first part of the study consists of sonication (572kHz) in the presence of zero-valent iron (ZVI) with or without H2O2 to select and optimize the operational parameters as frequency, time, initial solute concentration, dose of reagents and pH. The second part consists of the use of response surface methodology and multiple regression to develop an experimental design modeland to assess the individual and interactive effects of pH, power (Po), ZVI dose and H2O2...
November 2017: Ultrasonics Sonochemistry
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