Zuzana Palčeková, Kavita De, Shiva Kumar Angala, Martine Gilleron, Sophie Zuberogoitia, Lucie Gouxette, Maritza Soto-Ojeda, Mercedes Gonzalez-Juarrero, Andrés Obregón-Henao, Jérôme Nigou, William H Wheat, Mary Jackson
Two lipoglycans, lipomannan (LM) and lipoarabinomannan (LAM), play various, albeit incompletely defined, roles in the interactions of mycobacteria with the host. Growing evidence points to the modification of LM and LAM with discrete covalent substituents as a strategy used by these bacteria to modulate their biological activities. One such substituent, originally identified in Mycobacterium tuberculosis ( Mtb ), is a 5-methylthio-d-xylose (MTX) sugar, which accounts for the antioxidative properties of LAM...
March 21, 2024: ACS Infectious Diseases