keyword
Keywords rheumatoid, arthritis, sle, sc...

rheumatoid, arthritis, sle, scleroderma,

https://read.qxmd.com/read/37417009/spectrum-of-high-resolution-computed-tomography-pattern-in-lungs-in-patients-with-connective-tissue-disorders
#21
JOURNAL ARTICLE
Maheswar Chaudhury, E Hari Kishore, Likhitha Lingam, Adya Kinkar Panda
BACKGROUND: Connective tissue disease associated with interstitial lung disease, or CT-ILD, is a lung condition that affects a large number of patients with a connective tissue disease. OBJECTIVE: Our aim in this study is to correlation between images of high-resolution computed tomography (HRCT) of different connective tissue diseases associated interstitial lung diseases (CTD-ILDs). METHODS: We shall be aiming to investigate the feasibility of HRCT imaging and thereby avoid lung biopsy in such patients...
2023: Annals of African Medicine
https://read.qxmd.com/read/37399088/contemporary-outcomes-of-primary-total-hip-arthroplasty-in-patients-with-inflammatory-arthritis
#22
JOURNAL ARTICLE
Benjamin M Wooster, Nicholas I Kennedy, Evan M Dugdale, Rafael J Sierra, Kevin I Perry, Daniel J Berry, Matthew P Abdel
AIMS: Contemporary outcomes of primary total hip arthroplasties (THAs) with highly cross-linked polyethylene (HXLPE) liners in patients with inflammatory arthritis have not been well studied. This study examined the implant survivorship, complications, radiological results, and clinical outcomes of THA in patients with inflammatory arthritis. METHODS: We identified 418 hips (350 patients) with a primary diagnosis of inflammatory arthritis who underwent primary THA with HXLPE liners from January 2000 to December 2017...
July 1, 2023: Bone & Joint Journal
https://read.qxmd.com/read/37090544/glucose-6-phosphate-dehydrogenase-g6pd-deficiency-and-long-term-risk-of-immune-related-diseases
#23
Ariel Israel, Alejandro A Schäffer, Matitiahu Berkovitch, David J Ozeri, Eugene Merzon, Ilan Green, Avivit Golan-Cohen, Eytan Ruppin, Shlomo Vinker, Eli Magen
BACKGROUND: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked recessive enzymatic disorder, particularly prevalent in Africa, Asia and the Middle East. In the US, about 14% of black men are affected. Individuals with G6PD deficiency are often asymptomatic but may develop hemolysis following an infection or upon consumption of specific medications. Despite some evidence that G6PD deficiency affects the immune system, the long- term health risks associated with G6PD deficiency had not been studied in a large population...
March 24, 2023: medRxiv
https://read.qxmd.com/read/37076832/assessment-of-cardiopulmonary-manifestations-and-its-correlation-with-semi-quantitative-scoring-of-high-resolution-computed-tomography-in-patients-with-autoimmune-rheumatic-diseases
#24
JOURNAL ARTICLE
Mai M El-Kalashy, Samah A Elbeltagy, Enas S Zahran, Maha M Salman, Shrief R Abd Elrahman, Mai M Abdalraouf, Amal A El-Koa
PURPOSE: Autoimmune rheumatic diseases (ARD) are groups of diseases that are commonly associated with cardiac and pulmonary manifestations and may affect the morbidity and mortality of the patients. The study aimed to the assessment of cardiopulmonary manifestations and their correlation with the semi-quantitative scoring of high-resolution computed tomography (HRCT) in ARD patients. METHODS AND PATIENTS: 30 patients with ARD were included in the study (mean age 42...
April 19, 2023: BMC Pulmonary Medicine
https://read.qxmd.com/read/37075449/revisiting-femoral-cartilage-thickness-in-cases-with-hashimoto-s-thyroiditis-in-thyroidology-a-single-institute-experience
#25
JOURNAL ARTICLE
Nurce Cilesizoglu Yavuz, Oğuz Dikbaş, Fazıl Kulaklı, Ilker Fatih Sarı, Demet Sengul, Ilker Sengul
OBJECTIVE: Hashimoto's thyroiditis, also known as chronic lymphocytic thyroiditis or autoimmune thyroiditis, is a considerable part of the spectrum of chronic autoimmune thyroid gland disorders which is pathologically associated with various degrees of lymphocytic infiltration. The purpose of the present study was to evaluate whether cartilage thickness is affected in patients with Hashimoto's thyroiditis or not in thyroidology. METHODS: A total of 61 individuals had been evaluated in this case-control study, including 32 euthyroid Hashimoto's thyroiditis patients and 29 healthy subjects comparable in age, sex, and body mass index...
2023: Revista da Associação Médica Brasileira
https://read.qxmd.com/read/36889657/novel-aspects-of-muscle-involvement-in-immune-mediated-inflammatory-arthropathies-and-connective-tissue-diseases
#26
REVIEW
Sándor Mogyoróssy, Melinda Nagy-Vincze, Zoltán Griger, Katalin Dankó, Nóra Anna Szabó, Zoltán Szekanecz, Gabriella Szűcs, Antónia Szántó, Levente Bodoki
Myalgia, myopathy and myositis are the most important types of muscle impairment in immune-mediated inflammatory arthropathies and connective tissue diseases. Multiple pathogenetic and histological changes occur in the striated muscles of these patients. Clinically, the most important muscle involvement is the one that causes complaints to the patients. In everyday practice, insidious symptoms present a serious problem for the clinician; in many cases, it is difficult to decide when and how to treat the muscle symptoms that are often present only subclinically...
May 2023: Autoimmunity Reviews
https://read.qxmd.com/read/36884206/undifferentiated-connective-tissue-disease-comprehensive-review
#27
REVIEW
Jose Rubio, Vasileios C Kyttaris
PURPOSE OF REVIEW: Undifferentiated connective tissue disease (UCTD) is characterized by the presence of clinical symptoms of a systemic autoimmune disease in addition to laboratory evidence of autoimmunity with the patients not fulfilling any of the widely used classification criteria for classic autoimmune diseases. The presence of UCTD as a separate entity versus an early stage of such diseases as systemic lupus erythematosus (SLE) or scleroderma has long been debated. Given the uncertainty regarding this condition, we performed a systematic review on the topic...
May 2023: Current Rheumatology Reports
https://read.qxmd.com/read/36788878/overlap-syndrome-in-a-male-presenting-with-progressive-lower-limb-weakness-a-case-report
#28
Fatema M Dubai, Ahmed Isa
Overlap syndrome refers to a large group of inflammatory rheumatic conditions characterized by the co-existence of clinical manifestations that include different organ systems and meet the criteria of more than one rheumatic disease. Overlap syndromes are less common compared with the conditions they encompass, for example, the global prevalence of systemic lupus erythematosus (SLE) is estimated to be 43.7 per 100,000 persons, of which only around 3.4-6.3% present with SLE-myositis overlap. Although rare, overlap syndromes commonly include lupus, rheumatoid arthritis, scleroderma, and myositis...
January 2023: Curēus
https://read.qxmd.com/read/36434413/ventricular-and-atrial-function-assessment-with-transthoracic-echocardiography-in-patients-with-rheumatic-inflammatory-disease
#29
JOURNAL ARTICLE
Somayyeh Norouzi, Amirmohammad Khalaji, Mansoor Namazi, Somaye Sadat Rezaei, Amir Hossein Behnoush, Maryam Masoumi
BACKGROUND: Inflammatory rheumatic diseases, including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and systemic sclerosis (SSc), can cause cardiovascular complications in many cases. This study aimed to compare the ventricular and atrial functions of the heart between rheumatic patients and healthy controls using transthoracic echocardiography (TTE). RESULTS: The study was performed between 64 patients with mentioned rheumatic diseases and 64 age- and sex-matched healthy controls who all underwent detailed history-taking and TTE...
November 25, 2022: Egyptian Heart Journal: EHJ
https://read.qxmd.com/read/36396789/pulmonary-hypertension-in-connective-tissue-diseases-epidemiology-pathogenesis-and-treatment
#30
REVIEW
Döndü Üsküdar Cansu, Cengiz Korkmaz
Pulmonary hypertension (PH) is a clinical condition characterized by increased pulmonary arterial pressure arising from a heterogeneous range of diseases that has a deteriorating effect on the quality of life and may cause early mortality if left untreated. Connective tissue disorders (CTD)-associated PH is the second most common cause of pulmonary arterial hypertension (PAH), after the idiopathic form, categorized as group I. Systemic scleroderma (SSc) accounts for 75% of CTD-associated PH cases. Although SSc ranks first place for CTD-associated PH, SSc is followed by systemic lupus erythematosus (SLE) and mixed connective tissue disease (MCTD), having a lesser frequency of PH occurrence, while it occurs as a rare complication in cases with rheumatoid arthritis (RA) and inflammatory myositis...
October 2023: Clinical Rheumatology
https://read.qxmd.com/read/36274012/long-term-survival-analysis-of-free-flap-reconstruction-in-patients-with-collagen-vascular-disorders
#31
JOURNAL ARTICLE
Maria Yan, Sanjna Rajput, Kuldeep Singh, Brian T Carlsen, Steven L Moran, Jorys Martinez-Jorge, Aparna Vijayasekaran
BACKGROUND: Collagen vascular disorders (CVD) are inflammatory diseases that can affect the blood vessels and soft tissues. Patients with CVD are often immunosuppressed, prone to hyper-coagulation, and represent a challenging patient cohort for free tissue transfer. METHODS: A retrospective review of patients with CVD who underwent free flap reconstructions from 2000-2020 was performed at our institution. Inclusion criteria were patients 18 years old or older with the clinical diagnosis of CVD, including rheumatoid arthritis, Raynaud phenomenon, systemic lupus erythematosus, scleroderma, and sarcoidosis...
August 24, 2022: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://read.qxmd.com/read/36213848/treatment-of-fissure-caries-of-children-with-severe-rheumatic-diseases-with-difficulty-in-opening-the-mouth
#32
JOURNAL ARTICLE
Alla Anatolyevna Skakodub, Adil Askerovich Mamedov, Oleg Ivanovich Admakin, Olesya Viktorovna Dudnik, Arina Sergeevna Chertikhina, Aleksandra Romanovna Beznosik
Background: Pediatric dentists face difficulties in treating tooth decay of children with difficulty in opening the mouth. This is especially true, as the main disease is accompanied by such symptoms as arthritis, osteoarthritis, myositis, myalgia, sclerosis, and oral atrophy. Aim: The aim was to increase the level of treatment of fissure tooth decay for children with rheumatic diseases, using the silicone key method (SKM). Materials and Methods: A dental examination of 82 children was carried out, with diagnoses: systemic lupus erythematosus, juvenile systemic scleroderma, juvenile dermatomyositis, and juvenile rheumatoid arthritis...
July 2022: Contemporary Clinical Dentistry
https://read.qxmd.com/read/35896805/the-diagnostic-challenge-of-patients-with-anti-u1-rnp-antibodies
#33
JOURNAL ARTICLE
Ines Elhani, Kathy Khoy, Delphine Mariotte, Elisabeth Comby, Christian Marcelli, Brigitte Le Mauff, Alexandra Audemard-Verger, Jonathan Boutemy, Gwénola Maigné, Nicolas Martin Silva, Achille Aouba, Hubert de Boysson
Anti-U1-RNP antibodies are necessary for the diagnosis of mixed connective tissue disease (MCTD), but they are also prevalent in other connective tissue diseases, especially systemic lupus erythematosus (SLE), from which distinction remains challenging. We aimed to describe the presentation and outcome of patients with anti-U1-RNP antibodies and to identify factors to distinguish MCTD from SLE. We retrospectively applied the criteria sets for MCTD, SLE, systemic sclerosis (SSc) and rheumatoid arthritis (RA) to all patients displaying anti-U1-RNP antibodies in the hospital of Caen from 2000 to 2020...
July 27, 2022: Rheumatology International
https://read.qxmd.com/read/35747794/pathogenesis-and-treatment-of-t-large-granular-lymphocytic-leukemia-t-lgll-in-the-setting-of-rheumatic-disease
#34
REVIEW
Nina Couette, Wael Jarjour, Jonathan E Brammer, Alexa Simon Meara
A complex relationship exists between rheumatic diseases and cancer. This delicate balance between chronic inflammation and malignant cell transformation in hematologic neoplasms has been observed, but is not well defined. Large Granular Lymphocyte (LGL) leukemia is at the intersection of a clonal lymphoproliferative disease, chronic inflammation, and autoimmunity. The association between rheumatoid arthritis (RA) and the spectrum of Felty's Syndrome is well-known. Other rheumatic disorders have been reported including systemic lupus erythematosus (SLE), Sjogren's Syndrome (SS), vasculitis, Behcet's Disease (BD) and systemic sclerosis...
2022: Frontiers in Oncology
https://read.qxmd.com/read/35698669/lupus-cerebritis-as-a-rare-neuropsychiatric-manifestation-of-systemic-lupus-erythematosus
#35
Ayola R Leitao, Molly S Jain, Enkhmaa Luvsannyam, Vanita Jayswal, Frederick Tiesenga
Mixed connective tissue disease (MCTD) is a rare autoimmune condition that shows an overlap of at least two connective tissue diseases (CTD) including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), scleroderma, Sjögren's syndrome, polymyositis, or dermatomyositis. From a laboratory standpoint, MCTD is associated with high titers of anti-U1-RNP antibodies, which makes it difficult to determine whether it is a variant of each of the respective CTDs or a different entity altogether...
May 2022: Curēus
https://read.qxmd.com/read/35682106/the-relationship-between-9-11-exposure-systemic-autoimmune-disease-and-post-traumatic-stress-disorder-a-mediational-analysis
#36
JOURNAL ARTICLE
Jennifer Brite, Sara A Miller-Archie, James Cone
The relationship between 9/11 exposure, systemic autoimmune disease (SAD) and mental health remains poorly understood. This report builds on a prior analysis of World Trade Center Health Registry data to determine whether 9/11 exposure is associated with higher risk of SAD, and if so, whether post-traumatic stress disorder (PTSD) is a mediating factor and whether the association varies by responder/community member status. The final analytic sample comprised 41,656 enrollees with 123 cases of SAD diagnosed post 9/11 through November 2017...
May 27, 2022: International Journal of Environmental Research and Public Health
https://read.qxmd.com/read/35484889/clinical-usefulness-of-anti-cell-membrane-dna-autoantibodies-in-serology-negative-systemic-lupus-erythematosus
#37
JOURNAL ARTICLE
F N A Awang Kechik, M Abdullah, M Arip, M Hassan, H Mahayidin
INTRODUCTION: Systemic lupus erythematosus (SLE) diagnosis is dependent on the detection of serum autoantibodies. To date, there is no autoantibody highly sensitive and specific enough to be considered as a gold standard. This study aimed to determine the diagnostic usefulness of anti-cmDNA antibodies which found to be associated with SLE. MATERIALS AND METHODS: Serum samples from 83 SLE, 86 other connective tissue diseases (OCTD) and 61 healthy subjects were randomly selected for the study...
April 2022: Malaysian Journal of Pathology
https://read.qxmd.com/read/35383557/long-term-evaluation-of-pulmonary-function-and-survival-of-patients-with-interstitial-pneumonia-with-autoimmune-features
#38
JOURNAL ARTICLE
Julio A Huapaya, Afroditi Boulougoura, Julie Fried, Sepehr Mesdaghinia, Brooks J Culotta, Sara Carson, Peter J Bergquist, Pranay Krishnan, Haijun Wang, Cristina Reichner, Virginia Steen
OBJECTIVES: Interstitial pneumonia with autoimmune features (IPAF) includes patients with interstitial lung disease with autoimmune features who do not meet criteria for a connective tissue disease (CTD). Previous studies showed a wide variation in the radiologic pattern, pulmonary function and prognosis but there is still limited data on longitudinal outcomes. We aim to describe the long-term pulmonary function, radiological patterns, and survival of IPAF patients and explore a classification based on CTD-like subgroups by using clinical/serologic data...
March 30, 2022: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/35357093/the-five-major-autoimmune-diseases-increase-the-risk-of-cancer-epidemiological-data-from-a-large-scale-cohort-study-in-china
#39
JOURNAL ARTICLE
Ziyue Zhou, Huazhen Liu, Yiying Yang, Jingya Zhou, Lidan Zhao, Hua Chen, Yunyun Fei, Wen Zhang, Mengtao Li, Yan Zhao, Xiaofeng Zeng, Fengchun Zhang, Huaxia Yang, Xuan Zhang
BACKGROUND: Cancer incidence and mortality have received critical attention during the long-term management of morbidities in patients with autoimmune diseases (AIDs). This study aimed to investigate and compare the risk of cancer associated with five major AIDs in a large-scale Chinese cohort. METHODS: A total of 8,120 AID patients consecutively admitted to a national tertiary referral center in China were included and followed-up for 38,726.55 patient-years, including those with systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Sjögren's syndrome (SS), systemic scleroderma (SSc), and idiopathic inflammatory myositis (IIM)...
May 2022: Cancer Communications
https://read.qxmd.com/read/35125345/multipathway-in-vitro-pharmacological-characterization-of-specialized-proresolving-g-protein-coupled-receptors
#40
JOURNAL ARTICLE
Jon Merlin, Julia Park, Teresa H Vandekolk, Stewart A Fabb, Jeanne Allinne, Roger J Summers, Christopher J Langmead, Darren M Riddy
Specialized proresolving mediators (SPMs) and their cognate G protein-coupled receptors are implicated in autoimmune disorders, including chronic inflammation, rheumatoid arthritis, systemic scleroderma, and lupus erythematosus. To date, six G protein-coupled receptors (GPCRs) have been paired with numerous endogenous and synthetic ligands. However, the function and downstream signaling of these receptors remains unclear. To address this knowledge gap, we systematically expressed each receptor in a human embryonic kindney 293 (HEK293)-Flp-In-CD8a-FLAG cell system...
April 2022: Molecular Pharmacology
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