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Maximiliano Rapanelli
Histaminergic dysfunction has been recently linked to tic disorders and to aberrant striatal function. There is a particular interest in the histamine 3 receptor (H3R) due to its clinical implications for treating multiple disorders and its high expression in the brain. Striatal histamine (HA) modulates through the H3R in complex ways the release of striatal neurotransmitters into this brain region. The H3R has been classically described to be coupled to Gi, although there is evidence that revealed that striatal H3R forms heteromers with the dopamine receptors 1 and 2 in the medium spiny neurons (MSNs) than changes this signaling...
October 20, 2016: Progress in Neuro-psychopharmacology & Biological Psychiatry
Jaqueline de Paula Rezende, Guilherme Max Dias Ferreira, Gabriel Max Dias Ferreira, Luis Henrique Mendes da Silva, Maria do Carmo Hepanhol da Silva, Maximiliano Soares Pinto, Ana Clarissa Dos Santos Pires
Bovine serum albumin (BSA) has been recognized as a marker of the cow's health, milk quality, an allergenic protein and as a carrier. Its detection is important in the food, pharmaceutical and medical industries. However, traditional techniques used to detect BSA are often time-consuming, expensive, and show limited sensitivity. This paper describes properties of polydiacetylene-triblock copolymer (L64) nanosensors, synthesized to easily detect BSA. Sensor efficiency was studied as a function of nanosensor composition, polydiacetylene chemical structures, BSA conformation and hydrophobic domain availability, using spectroscopic, calorimetric, light scattering, and electrokinetic analyses...
January 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
Miao He, Jason Tucciarone, SooHyun Lee, Maximiliano José Nigro, Yongsoo Kim, Jesse Maurica Levine, Sean Michael Kelly, Illya Krugikov, Priscilla Wu, Yang Chen, Ling Gong, Yongjie Hou, Pavel Osten, Bernardo Rudy, Z Josh Huang
No abstract text is available yet for this article.
October 19, 2016: Neuron
Maximiliano L Agazzi, M Belén Ballatore, Eugenia Reynoso, Ezequiel D Quiroga, Edgardo N Durantini
Two cationic BODIPYs 3 and 4 were synthesized by acid-catalyzed condensation of the corresponding pyrrole and benzaldehyde, followed by complexation with boron and methylation. Compound 3 contains methyl at the 1,3,5 and 7 positions of the s-indacene ring and a N,N,N-trimethylamino group attached to the phenylene unit, while 4 is not substituted by methyl groups and the cationic group is bound by an aliphatic spacer. UV-visible absorption spectra of these BODIPYs show an intense band at ∼500 nm in solvents of different polarities and n-heptane/sodium bis(2-ethylhexyl)sulfosuccinate (AOT)/water reverse micelles...
October 3, 2016: European Journal of Medicinal Chemistry
Arvind Sivasubramanian, Patricia Estep, Heather Lynaugh, Yao Yu, Adam Miles, Josh Eckman, Kevin Schutz, Crystal Piffath, Nadthakarn Boland, Rebecca Hurley Niles, Stéphanie Durand, Todd Boland, Maximiliano Vásquez, Yingda Xu, Yasmina Abdiche
Successful discovery of therapeutic antibodies hinges on the identification of appropriate affinity binders targeting a diversity of molecular epitopes presented by the antigen. Antibody campaigns that yield such broad "epitope coverage" increase the likelihood of identifying candidates with the desired biological functions. Accordingly, epitope binning assays are employed in the early discovery stages to partition antibodies into epitope families or "bins" and prioritize leads for further characterization and optimization...
October 17, 2016: MAbs
Diane Goéré, Maximiliano Gelli
No abstract text is available yet for this article.
October 12, 2016: Lancet Oncology
Anelise Fernandes Montagner, Niek J Opdam, Jan L Ruben, Maximiliano Sérgio Cenci, Marie-Charlotte Huysmans
This study evaluated the effect of mechanical loading with a new device on the microtensile bond strength (µTBS) of adhesive systems to dentin. Forty molars were divided according to adhesive systems: self-etch (Clearfil(TM) SE Bond -CSE) and etch-and-rinse (Adper Scotchbond(TM) 1XT -ASB); and to aging (n=5): control; MC1-250,000; MC2-500,000; and MC3-750,000 mechanical cycles. Microtensile bond strength was measured and fracture modes were analyzed. Data for µTBS were subjected to Kruskal-Wallis and post hoc tests (p<0...
October 1, 2016: Dental Materials Journal
Alicia Pitrella, Andrés Domínguez, Walter Camus, Maximiliano Nocetti, Iván Boroni
No abstract text is available yet for this article.
2016: Medicina
Eleonora Zambrano Blanco, Miklos Maximiliano Bajay, Marcos Vinícius Bohrer Monteiro Siqueira, Maria Imaculada Zucchi, José Baldin Pinheiro
Ginger is a vegetable with medicinal and culinary properties widely cultivated in the Southern and Southeastern Brazil. The knowledge of ginger species' genetic variability is essential to direct correctly future studies of conservation and genetic improvement, but in Brazil, little is known about this species' genetic variability. In this study, we analyzed the genetic diversity and structure of 55 Brazilian accessions and 6 Colombian accessions of ginger, using AFLP (Amplified Fragment Length Polymorphism) molecular markers...
October 8, 2016: Genetica
Jean-Sebastien Provost, Simona M Brambati, Marianne Chapleau, Maximiliano A Wilson
Cognitive and computational models of reading aloud agree on the existence of two procedures for reading. Pseudowords (e.g., atendier) are correctly read through subword processes only while exception words (e.g., pint) are only correctly read via whole-words processes. Regular words can be correctly read by means of either way. Previous behavioral studies showed that older adults relied more on whole-word processing for reading. The aim of the present fMRI study was to verify whether this larger whole-word reliance for reading in older adults was reflected by changes in the pattern of brain activation...
September 17, 2016: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
Fabiano A Tofoli, Maximiliano Dasso, Mariana Morato-Marques, Kelly Nunes, Lucas Assis Pereira, Giselle Siqueira da Silva, Simone A S Fonseca, Roberta Montero Costas, Hadassa Campos Santos, Alexandre da Costa Pereira, Paulo A Lotufo, Isabela M Bensenor, Diogo Meyer, Lygia Veiga Pereira
Human pluripotent stem cells (hPSCs) may significantly improve drug development pipeline, serving as an in vitro system for the identification of novel leads, and for testing drug toxicity. Furthermore, these cells may be used to address the issue of differential drug response, a phenomenon greatly influenced by genetic factors. This application depends on the availability of hPSC lines from populations with diverse ancestries. So far, it has been reported that most lines of hPSCs derived worldwide are of European or East Asian ancestries...
October 6, 2016: Scientific Reports
Norma G Pilnik, Veronica Bengio, Maximiliano Canigiani, Pilar Diaz, Marcelo De La Colina
No abstract text is available yet for this article.
October 2016: Journal of Thoracic Oncology
Carini Aparecida Lelis, Eliara Acipreste Hudson, Guilherme Max Dias Ferreira, Gabriel Max Dias Ferreira, Luis Henrique Mendes da Silva, Maria do Carmo Hespanhol da Silva, Maximiliano Soares Pinto, Ana Clarissa Dos Santos Pires
The interaction between Allura Red and bovine serum albumin (BSA) was studied in vitro at pH 7.4. The fluorescence quenching was classified as static quenching due to the formation of AR-BSA complex, with binding constant (K) ranging from 3.26±0.09 to 8.08±0.0610(4)L.mol(-1), at the warfarin binding site of BSA. This complex formation was driven by increasing entropy. Isothermal titration calorimetric measurements also showed an enthalpic contribution. The Allura Red diffusion coefficient determined by the Taylor-Aris technique corroborated these results because it reduced with increasing BSA concentration...
February 15, 2017: Food Chemistry
Maribel Botana-Rial, Virginia Leiro-Fernández, Manuel Núñez-Delgado, Maximiliano Álvarez-Fernández, Susana Otero-Fernández, Helena Bello-Rodríguez, Carlos Vilariño-Pombo, Alberto Fernández-Villar
BACKGROUND: Endoscopes represent the medical devices most commonly linked to health care-associated outbreaks and pseudo-outbreaks. Most of the recent outbreaks and pseudo-outbreaks have resulted from contaminated automated endoscope reprocessors (AER) or the use of damaged or malfunctioning bronchoscopes or contaminated equipment. OBJECTIVES: We investigated a pseudo-outbreak of Pseudomonas putida and Stenotrophomonas maltophilia recovered from bronchial washing (BW) specimens obtained during bronchoscopy in a bronchoscopy unit...
2016: Respiration; International Review of Thoracic Diseases
Georges Chedid, Maximiliano A Wilson, Jean-Sebastien Provost, Sven Joubert, Isabelle Rouleau, Simona M Brambati
The ability to recognize a famous person occurs through semantic memory. Previous neuroimaging studies have shown that the anterior temporal lobes (ATLs) are involved in the recognition of famous people. However, it is still a matter of debate whether the semantic processing of names or pictures of famous people has an impact on the activation of ATLs. The aim of this study was to explore the pattern of activation associated with a semantic processing of famous people based on face and written name stimuli...
2016: Frontiers in Psychology
Miao He, Jason Tucciarone, SooHyun Lee, Maximiliano José Nigro, Yongsoo Kim, Jesse Maurica Levine, Sean Michael Kelly, Illya Krugikov, Priscilla Wu, Yang Chen, Lin Gong, Yongjie Hou, Pavel Osten, Bernardo Rudy, Z Josh Huang
Systematic genetic access to GABAergic cell types will facilitate studying the function and development of inhibitory circuitry. However, single gene-driven recombinase lines mark relatively broad and heterogeneous cell populations. Although intersectional approaches improve precision, it remains unclear whether they can capture cell types defined by multiple features. Here we demonstrate that combinatorial genetic and viral approaches target restricted GABAergic subpopulations and cell types characterized by distinct laminar location, morphology, axonal projection, and electrophysiological properties...
September 21, 2016: Neuron
Juan Carlos Rosillo, Maximiliano Torres, Silvia Olivera-Bravo, Gabriela Casanova, José Manuel García-Verdugo, Anabel Sonia Fernández
Adult neurogenesis participates in fish olfaction sensitivity in response to environmental challenges. Therefore, we investigated if several populations of stem/progenitor cells that are retained in the olfactory bulbs (OB) may constitute different neurogenic niches that support growth and functional demands. By electron microscopy and combination cell proliferation and lineage markers, we found that the telencephalic ventricle wall (VW) at OB level of Austrolebias charrua fish presents three neurogenic niches (transitional 1, medial 2 and ventral 3)...
November 12, 2016: Neuroscience
Cristián Barrientos, Maximiliano Barahona, Jorge Diaz, Julian Brañes, Felipe Chaparro, Jaime Hinzpeter
The normal value of alpha angle is controversial. The aim of this study was to compare the alpha angle in asymptomatic volunteers versus patients who had undergone surgery for symptomatic cam-type femoroacetabular impingement (FAI) and determine a diagnostic cut-off value for symptomatic cam impingement. This is a diagnostic test study. Cases were defined as those patients who had undergone surgery for symptomatic cam or mixed type FAI. Controls were defined as asymptomatic volunteers, with no history of hip pain who had undergone a computed tomography (CT) scan of the abdomen and pelvis for a non-joint or bone-related reason...
August 2016: Journal of Hip Preservation Surgery
Maximiliano Lopez Silva, Horacio Sanguinetti, Santiago Battiston, Patricio Alvarez, Norberto Bernardo
Patients with severe skeletal deformities are a challenging group to treat. A female, white, 35-year-old presented with right kidney stones located in renal pelvis, lower calyx, and upper ureter. She was affected by severe spinal deformity with restrictive respiratory obstruction, caused by kyphoscoliosis. Percutaneous nephrolithotomy in supine position was performed, achieving complete removal of kidney stones. The treatment of renal stones in this patient was complex, so special attention to respiratory function was mandatory; this was a challenging but feasible situation...
2016: J Endourol Case Rep
Christoph Hönigsperger, Maximiliano J Nigro, Johan F Storm
The medial entorhinal cortex (mEC) is strongly involved in spatial navigation, memory, dementia and epilepsy. Although potassium channels shape neuronal activity, their roles in mEC are largely unknown. We used the new Kv2 blocker Guangxitoxin-1E (GTx, 10-100 nm) in rat brain slices to investigate Kv2 channel functions in mEC layer II stellate cells (SCs). These neurons project to the hippocampus and are thought to be grid cells representing space. Voltage clamp recordings from SCs nucleated patches showed that GTx inhibited a delayed rectifier K(+) current activating beyond -30 mV, but not transient, A-type current...
August 26, 2016: Journal of Physiology
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