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Maximiliano

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https://www.readbyqxmd.com/read/28639484/detection-test-for-language-impairments-in-adults-and-the-aged-a-new-screening-test-for-language-impairment-associated-with-neurodegenerative-diseases-validation-and-normative-data
#1
Joël Macoir, Marion Fossard, Laurent Lefebvre, Laura Monetta, Antoine Renard, Thi Mai Tran, Maximiliano A Wilson
To date, there is no quick screening test that could be used during routine office visits to accurately assess language disorders in neurodegenerative diseases. To fill this important gap, we developed the Detection Test for Language impairments in Adults and the Aged (DTLA), a quick, sensitive, standardized screening test designed to assess language disorders in adults and the elderly individuals. In Study 1, we describe the development of the DTLA. In Study 2, we report data on the DTLA's validity and reliability...
January 1, 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/28639064/whole-lipid-profile-and-not-only-hdl-cholesterol-is-impaired-in-children-with-coexisting-type-1-diabetes-and-untreated-celiac-disease
#2
Silvana Salardi, Giulio Maltoni, Stefano Zucchini, Dario Iafusco, Angela Zanfardino, Santino Confetto, Sonia Toni, Maximiliano Zioutas, Marco Marigliano, Vittoria Cauvin, Roberto Franceschi, Ivana Rabbone, Barbara Predieri, Riccardo Schiaffini, Alessandro Salvatoni
AIMS: Low HDL cholesterol (HDL-C) levels have been described in patients with coexisting type 1 diabetes mellitus (T1DM) and celiac disease (CD). Data on other possible lipid abnormalities that could further increase cardiovascular risk in these patients are scarce and incomplete. Aim of this retrospective multicenter study was to evaluate whole lipid profiles, besides HDL-C, in children with T1DM associated with biopsy-proven CD, and to investigate the influence of age and degree of adherence to gluten-free diet (GFD) on lipid changes...
June 21, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28633586/porphyromonas-gingivalis-and-its-lps-differentially-regulate-the-expression-of-peptidyl-arginine-deiminases-in-human-chondrocytes
#3
René Elkaim, Isaac Maximiliano Bugueno-Valdebenito, Nadia Benkirane-Jessel, Henri Tenenbaum
Periodontitis, an inflammatory disease initiated by Gram-negative bacteria such as Porphyromonas gingivalis ( Pg), is considered as a risk factor for rheumatoid arthritis (RA). Our study aimed to determine the effect of Pg and its LPS on the expression of peptidyl arginine deiminase isotypes (PADs) in human primary chondrocytes (HC). HCs were infected with Pg and activated by its LPS (LPS- Pg). The mRNA expression levels of human PADs (1, 2, 3, 4 and 6) and bacterial enzyme (PADPg) were quantified by RT-qPCR...
January 1, 2017: Innate Immunity
https://www.readbyqxmd.com/read/28603593/markers-of-inflammation-and-cardiovascular-disease-in-recently-diagnosed-celiac-disease-patients
#4
Walter F Tetzlaff, Tomás Meroño, Martin Menafra, Maximiliano Martin, Eliana Botta, Maria D Matoso, Patricia Sorroche, Juan A De Paula, Laura E Boero, Fernando Brites
AIM: To evaluate novel risk factors and biomarkers of cardiovascular disease in celiac disease (CD) patients compared with healthy controls. METHODS: Twenty adult patients with recent diagnosis of CD and 20 sex, age and body mass index-matched healthy controls were recruited during a period of 12 mo. Indicators of carbohydrate metabolism, hematological parameters and high sensitive C reactive protein were determined. Moreover, lipoprotein metabolism was also explored through evaluation of the lipid profile and the activity of cholesteryl ester transfer protein and lipoprotein associated phospholipase A2, which is also considered a specific marker of vascular inflammation...
May 26, 2017: World Journal of Cardiology
https://www.readbyqxmd.com/read/28586646/nuclear-pores-regulate-muscle-development-and-maintenance-by-assembling-a-localized-mef2c-complex
#5
Marcela Raices, Lucas Bukata, Stephen Sakuma, Joana Borlido, Leanora S Hernandez, Daniel O Hart, Maximiliano A D'Angelo
Nuclear pore complexes (NPCs) are multiprotein channels connecting the nucleus with the cytoplasm. NPCs have been shown to have tissue-specific composition, suggesting that their function can be specialized. However, the physiological roles of NPC composition changes and their impacts on cellular processes remain unclear. Here we show that the addition of the Nup210 nucleoporin to NPCs during myoblast differentiation results in assembly of an Mef2C transcriptional complex required for efficient expression of muscle structural genes and microRNAs...
June 5, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28584117/histamine-modulation-of-the-basal-ganglia-circuitry-in-the-development-of-pathological-grooming
#6
Maximiliano Rapanelli, Luciana Frick, Haruhiko Bito, Christopher Pittenger
Aberrant histaminergic function has been proposed as a cause of tic disorders. A rare mutation in the enzyme that produces histamine (HA), histidine decarboxylase (HDC), has been identified in patients with Tourette syndrome (TS). Hdc knockout mice exhibit repetitive behavioral pathology and neurochemical characteristics of TS, establishing them as a plausible model of tic pathophysiology. Where, when, and how HA deficiency produces these effects has remained unclear: whether the contribution of HA deficiency to pathogenesis is acute or developmental, and where in the brain the relevant consequences of HA deficiency occur...
June 20, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28580241/lateral-capsular-fixation-an-implant-free-technique-to-prevent-meniscal-allograft-extrusion
#7
Joan C Monllau, Maximiliano Ibañez, Angel Masferrer-Pino, Pablo E Gelber, Juan I Erquicia, Xavier Pelfort
Although several surgical techniques have been described to perform meniscal allograft transplantation with good clinical results and although different methods of capsular stabilization can be found in the literature, there is no standard surgical technique to prevent a common complication in the most of series: the tendency to a radial displacement or extrusion of the transplanted menisci. We present a simple, reproducible, and implant-free technique to perform a lateral capsular fixation (capsulodesis) at the time of only the soft-tissue fixation technique of meniscal allograft transplantation in an effort to reduce or prevent the risk of graft extrusion...
April 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28578790/the-role-of-interneurons-in-autism-and-tourette-syndrome
#8
REVIEW
Maximiliano Rapanelli, Luciana Romina Frick, Christopher Pittenger
The brain includes multiple types of interconnected excitatory and inhibitory neurons that together allow us to move, think, feel, and interact with the environment. Inhibitory interneurons (INs) comprise a small, heterogeneous fraction, but they exert a powerful and tight control over neuronal activity and consequently modulate the magnitude of neuronal output and, ultimately, information processing. IN abnormalities are linked to two pediatric psychiatric disorders with high comorbidity: autism spectrum disorder (ASD) and Tourette syndrome (TS)...
May 31, 2017: Trends in Neurosciences
https://www.readbyqxmd.com/read/28548192/-benzodiazepine-use-in-elderly-population-in-latin-america
#9
Saúl Gómez, Tomás León, Maximiliano Macuer, Mariana Alves, Sergio Ruiz
BACKGROUND: Growing information has emphasized the risk of benzodiazepines (BZD), particularly among the elderly. However, the information available in Latin America is scarce. AIM: to review the available information on the use of BZD in older adults in Latin America to achieve an overview of the information currently available, and a thorough understanding of this phenomenon in our region. METHODS: A systematic review with MeSH terms “elderly”, “latinamerican” and “benzodiazepines” was performed in PubMed and with each Latin American country...
March 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/28542288/structural-models-of-the-different-trimers-present-in-the-core-of-phycobilisomes-from-gracilaria-chilensis-based-on-crystal-structures-and-sequences
#10
Jorge Dagnino-Leone, Maximiliano Figueroa, Claudia Mella, María Alejandra Vorphal, Frédéric Kerff, Aleikar José Vásquez, Marta Bunster, José Martínez-Oyanedel
Phycobilisomes (PBS) are accessory light harvesting protein complexes that directionally transfer energy towards photosystems. Phycobilisomes are organized in a central core and rods radiating from it. Components of phycobilisomes in Gracilaria chilensis (Gch) are Phycobiliproteins (PBPs), Phycoerythrin (PE), and Phycocyanin (PC) in the rods, while Allophycocyanin (APC) is found in the core, and linker proteins (L). The function of such complexes depends on the structure of each component and their interaction...
2017: PloS One
https://www.readbyqxmd.com/read/28540831/ninety-percent-of-the-adverse-outcomes-occur-in-ten-percent-of-patients-can-we-identify-the-populations-at-high-risk-of-developing-peritoneal-metastases-after-curative-surgery-for-colorectal-cancer
#11
Charles Honoré, Maximiliano Gelli, Julie Francoual, Léonor Benhaim, Dominique Elias, Diane Goéré
BACKGROUND: Peritoneal metastases (PM) occur in 3.4% to 6.3% after curative surgery for non-metastatic colorectal cancer. Systematic "2(nd) look" surgery help overcoming the diagnostic problem but can be only proposed to selected patients. The aim of this study was to update the knowledge on risk factors of developing PM after curative surgery for colorectal cancer. METHODS: A systematic review of the literature published between 2011 and 2016 was made, searching for all clinical studies reporting the incidence of recurrent PM after curative surgery for colorectal cancer and factors associated with the primary tumor that were likely to influence this recurrence rate...
March 29, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28540827/complete-cytoreductive-surgery-plus-hipec-for-peritoneal-metastases-from-unusual-cancer-sites-of-origin-results-from-a-worldwide-analysis-issue-of-the-peritoneal-surface-oncology-group-international-psogi
#12
Diane Goéré, Guillaume Passot, Maximiliano Gelli, Edward A Levine, David L Bartlett, Paul H Sugarbaker, Olivier Glehen
AIM: The aim of this study was to assess the outcomes of patients operated on for peritoneal metastases from unusual cancer sites of origin, meaning apart from PM from colorectal, gastric and epithelial ovarian carcinomas, pseudomyxoma peritonei and mesothelioma. PATIENTS AND METHODS: A questionnaire concerning patients treated with CRS plus HIPEC for PM arising from unusual cancer sites of origin was sent to all centers that routinely performed HIPEC, through the Peritoneal Surface Oncology Group International and the RENAPE network...
March 8, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28534321/does-anatomic-single-bundle-acl-reconstruction-using-hamstring-autograft-produce-anterolateral-meniscal-root-tearing
#13
Sebastián Irarrázaval, Angel Masferrer-Pino, Maximiliano Ibañez, Tamer M A Shehata, María Naharro, Joan C Monllau
BACKGROUND: To determine if tibial tunnel reaming during anatomic single-bundle anterior cruciate ligament (ACL) reconstruction using hamstring autograft can result in anterolateral meniscal root injury, as diagnosed by magnetic resonance imaging (MRI). METHODS: A case series of 104 primary anatomic single-bundle ACL reconstructions using hamstring autograft was retrospectively reviewed. Pre- and post-operative (>1 year) MRIs were radiologically evaluated for each patient, with a lateral meniscus extrusion > 3 mm at the level of the medial collateral ligament midportion on a coronal MRI, to establish anterolateral meniscal root injury...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28528250/antifungal-toxicity-of-linear-geranylphenol-influence-of-oxigenate-substituents
#14
Lautaro Taborga, Maximiliano Sortino, Carrasco Héctor, Estefanía Butassi, Susana Zacchino, Luis Espinoza
Twenty four linear geranylphenols were evaluated for their antifungal properties against ATCC and clinical isolates of Candida albicans and Cryptococcus neoformans. For the analysis of their antifungal behavior the compounds were grouped into two series: (i) compounds with only one geranyl substituent on the benzene ring and (ii) compounds with two geranyl moieties on the benzene ring. Results showed that compounds of series (i) present better antifungal activities than those of series (ii). In addition, within group (i) all compounds showed better activities against C...
May 17, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28506892/the-roles-of-the-nuclear-pore-complex-in-cellular-dysfunction-aging-and-disease
#15
REVIEW
Stephen Sakuma, Maximiliano A D'Angelo
The study of the Nuclear Pore Complex (NPC), the proteins that compose it (nucleoporins), and the nucleocytoplasmic transport that it controls have revealed an unexpected layer to pathogenic disease onset and progression. Recent advances in the study of the regulation of NPC composition and function suggest that the precise control of this structure is necessary to prevent diseases from arising or progressing. Here we discuss the role of nucleoporins in a diverse set of diseases, many of which directly or indirectly increase in occurrence and severity as we age, and often shorten the human lifespan...
May 12, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28505107/raman-spectroscopy-of-head-and-neck-cancer-separation-of-malignant-and-healthy-tissue-using-signatures-outside-the-fingerprint-region
#16
Stephen Holler, Elaina Mansley, Christopher Mazzeo, Michael J Donovan, Maximiliano Sobrero, Brett A Miles
The ability to rapidly and accurately discriminate between healthy and malignant tissue offers surgeons a tool for in vivo analysis that would potentially reduce operating time, facilitate quicker recovery, and improve patient outcomes. To this end, we investigate discrimination between diseased tissue and adjacent healthy controls from patients with head and neck cancer using near-infrared Raman spectroscopy. Our results indicate previously unreported peaks in the Raman spectra that lie outside the conventional "fingerprint" region (400 cm-1-1800 cm -1) played an important role in our analysis and in discriminating between the tissue classes...
May 14, 2017: Biosensors
https://www.readbyqxmd.com/read/28501439/paclitaxel-what-has-been-done-and-the-challenges-remain-ahead
#17
REVIEW
Ezequiel Bernabeu, Maximiliano Cagel, Eduardo Lagomarsino, Marcela Moretton, Diego A Chiappetta
In recent years, the nanotechnology has offered researchers the opportunity to solve the problems caused by the vehicle of the standard and first formulation of paclitaxel (Taxol(®)), while maximizing the proven antineoplastic activity of the drug against many solid tumors. Hence, different types of nanocarriers have been employed to improve the efficacy, safety, physicochemical properties and pharmacokinetic/pharmacodynamic profile of this drug. To date, paclitaxel is the unique drug that is marketed in three different nanoplatforms for its parenteral delivery: polymeric nanoparticles (Abraxane(®)), liposomes (Lipusu(®)), and polymeric micelles (Genexol(®), Nanoxel(®) and Paclical(®))...
June 30, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28500327/metazoan-ribosome-inactivating-protein-encoding-genes-acquired-by-horizontal-gene-transfer
#18
Walter J Lapadula, Paula L Marcet, María L Mascotti, M Virginia Sanchez-Puerta, Maximiliano Juri Ayub
Ribosome inactivating proteins (RIPs) are RNA N-glycosidases that depurinate a specific adenine residue in the conserved sarcin/ricin loop of 28S rRNA. These enzymes are widely distributed among plants and their presence has also been confirmed in several bacterial species. Recently, we reported for the first time in silico evidence of RIP encoding genes in metazoans, in two closely related species of insects: Aedes aegypti and Culex quinquefasciatus. Here, we have experimentally confirmed the presence of these genes in mosquitoes and attempted to unveil their evolutionary history...
May 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28494243/a-rab20-dependent-membrane-trafficking-pathway-controls-m-%C3%A2-tuberculosis-replication-by-regulating-phagosome-spaciousness-and-integrity
#19
Laura Schnettger, Angela Rodgers, Urska Repnik, Rachel P Lai, Gang Pei, Martijn Verdoes, Robert J Wilkinson, Douglas B Young, Maximiliano G Gutierrez
The intracellular pathogen Mycobacterium tuberculosis (Mtb) lives within phagosomes and also disrupts these organelles to access the cytosol. The host pathways and mechanisms that contribute to maintaining Mtb phagosome integrity have not been investigated. Here, we examined the spatiotemporal dynamics of Mtb-containing phagosomes and identified an interferon-gamma-stimulated and Rab20-dependent membrane trafficking pathway in macrophages that maintains Mtb in spacious proteolytic phagolysosomes. This pathway functions to promote endosomal membrane influx in infected macrophages, and is required to preserve Mtb phagosome integrity and control Mtb replication...
May 10, 2017: Cell Host & Microbe
https://www.readbyqxmd.com/read/28487799/primary-meningococcal-type-c-arthritis-a-case-report-and-literature-review
#20
Maximiliano Barahona, Jaime Catalan, Yoshiro Sato, Jaime Hinzpeter
Acute septic arthritis is a common clinical problem in emergency departments. Primary meningococcal arthritis (PMA) is very rare and few cases are reported in literature. D. B. M. consulted the emergency department for knee pain and fever; analysis showed that the cause was a Neisseria meningitidis type C infection. He received a treatment consisting of 2 arthroscopies and 5 weeks of antibiotics. At five weeks he returned to work and at 2 months he resumed sports (jogging and soccer) without complaints. Primary arthritis of the knee caused by Neisseria meningitidis is very rare...
2017: Case Reports in Orthopedics
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