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https://www.readbyqxmd.com/read/28432988/comprehension-of-concrete-and-abstract-words-in-semantic-variant-primary-progressive-aphasia-and-alzheimer-s-disease-a-behavioral-and-neuroimaging-study
#1
Sven Joubert, Guillaume T Vallet, Maxime Montembeault, Mariem Boukadi, Maximiliano A Wilson, Robert Jr Laforce, Isabelle Rouleau, Simona M Brambati
The aim of this study was to investigate the comprehension of concrete, abstract and abstract emotional words in semantic variant primary progressive aphasia (svPPA), Alzheimer's disease (AD), and healthy elderly adults (HE) Three groups of participants (9 svPPA, 12 AD, 11 HE) underwent a general neuropsychological assessment, a similarity judgment task, and structural brain MRI. The three types of words were processed similarly in the group of AD participants. In contrast, patients in the svPPA group were significantly more impaired at processing concrete words than abstract words, while comprehension of abstract emotional words was in between...
April 19, 2017: Brain and Language
https://www.readbyqxmd.com/read/28432720/androgen-receptor-dysfunction-as-a-prevalent-manifestation-in-young-male-carriers-of-a-flna-gene-mutation
#2
Laura Carrera-García, Maximiliano Francisco Rivas-Crespo, María Soledad Fernández García
Androgenic actions require the proper signal transmission by the androgen receptor (AR), a nuclear transcription factor. This is initially located in the cell cytoplasm and should translocates to the nucleus to interact with DNA. AR functional impairment causes diverse blockage degrees of androgenic steroid action, known as androgen insensitivity syndromes. Filamin A, a protein coded by the FLNA gene, is a co-activator of various cytoplasmic factors, including AR. The mutational inactivation of the FLNA gene induces insufficiency of translocation and activation of AR...
April 21, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28427300/object-decision-test-borb-normative-data-for-the-adult-quebec-population-and-performance-in-alzheimer-s-disease-and-the-semantic-variant-of-primary-progressive-aphasia
#3
Alexandre St-Hilaire, Marie-Claude Blackburn, Maximiliano A Wilson, Robert Jr Laforce, Carol Hudon, Joël Macoir
Object decision (OD) test is one subtest of the Birmingham Object Recognition Battery (BORB). It is useful for differential diagnosis among several neurodegenerative diseases. However, normative data provided with this battery count on very few subjects and do not control for the effect of age, which limits interpretability. The purpose of Study 1 was to provide normative data for the OD test of the BORB (version A-hard). The objectives of Study 2 were to establish the diagnostic validity of this task and predictive validity of the normative data in the case of the semantic variant of primary progressive aphasia (svPPA) and Alzheimer's disease (AD)...
April 21, 2017: Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition
https://www.readbyqxmd.com/read/28424650/the-role-of-the-left-anterior-temporal-lobe-for-unpredictable-and-complex-mappings-in-word-reading
#4
Marilyne Joyal, Simona M Brambati, Robert J Laforce, Maxime Montembeault, Mariem Boukadi, Isabelle Rouleau, Joël Macoir, Sven Joubert, Shirley Fecteau, Maximiliano A Wilson
The anterior temporal lobes (ATLs) have been consistently associated with semantic processing which, in turn, has a key role in reading aloud single words. This study aimed to investigate (1) the reading abilities in patients with the semantic variant of primary progressive aphasia (svPPA), and (2) the relationship between gray matter (GM) volume of the left ATL and word reading performance using voxel-based morphometry (VBM). Three groups of participants (svPPA, Alzheimer's Disease, AD and healthy elderly adults) performed a reading task with exception words, regular words and pseudowords, along with a structural magnetic resonance imaging scan...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28421368/recombinant-foot-and-mouth-disease-virus-fmdv-non-structural-protein-3a-fused-to-enhanced-green-fluorescent-protein-egfp-as-a-candidate-probe-to-identify-fmdv-infected-cattle-in-serosurveys
#5
Cecilia M Lotufo, Ingrid E Bergmann, Nora M Mattion, Maximiliano Wilda, Pablo R Grigera
Recombinant protein 3A-EGFP, a fusion construct between foot-and-mouth disease virus (FMDV) non-structural protein 3A and the enhanced green fluorescent protein (EGFP) was expressed in BL21-DE3 cells. The identity of the partially purified protein 3A-EGFP was confirmed by its reactivity with sera from cattle infected with FMDV and with a monoclonal antibody specific for FMDV-3ABC (MAb3H7) in Western blot assays. No reactivity was observed with sera from uninfected vaccinated animals. The performance of 3A-EGFP as an antigen in an indirect enzyme-linked immunosorbent assay (ELISA) was assessed and compared with that of a previously developed and validated capture ELISA that uses a 3ABC recombinant antigen (3ABC ELISA) and has been widely applied for serological surveys in Argentina...
April 18, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28410957/fetal-alpha-5-reductase-val89leu-mutation-is-associated-with-late-miscarriage
#6
Beatriz Pérez-Nevot, Jose-Luis Royo, Miriam Cortés, Ana M Lendínez, Arturo Reyes-Palomares, Ana-José Jiménez, Maximiliano Ruiz-Galdón, Armando Reyes-Engel
The present study was undertaken to determine the role of different polymorphisms affecting the testosterone/oestrogen pathway in miscarriage. Alpha 5-reductase (SRD5A2) rs523349 and rs9282858, cytochrome P450 aromatase (CYP19A1) rs4646, rs10046 and rs2236722 and oestrogen receptor (ESR1) rs9340799, rs2234693 and rs6932902 polymorphisms were selected. The case group consisted of 94 samples of formalin-fixed and paraffin-embedded fetal tissue from a miscarriage at ≤24 weeks. The control group comprised a population of 331 young healthy subjects...
March 21, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28405810/what-is-the-most-reproducible-classification-system-to-assess-tibial-plateau-fractures
#7
Angélica Millán-Billi, Mireia Gómez-Masdeu, Eduard Ramírez-Bermejo, Maximiliano Ibañez, Pablo Eduardo Gelber
PURPOSE: Traditional classification systems for tibial plateau fractures (TPF) are based on simple radiographs, and intra- and inter-observer variability is low. The aim was to assess intra- and inter-observer variability using traditional systems and some recently described classification systems of TPF in the interpretation of standard radiographs and bidimensional (2D) and tridimensional (3D) computed tomography (CT). METHODS: We studied all patients at two centres who underwent TPF surgery over a three-year period...
April 13, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28403481/do-flow-and-pulsatility-index-within-the-accepted-ranges-predict-long-term-outcomes-after-coronary-artery-bypass-grafting
#8
Maximiliano De Leon, Roberto Stanham, Gerardo Soca, Victor Dayan
Background Transit-time flow measurement (TTFM) is the gold standard for intraoperative detection of graft failure. Several reports show that TTFM and distal coronary bed quality (DCBQ) may also be useful for midterm detection of graft failure. Nonetheless, there are no data regarding their predictive role on long-term outcomes. Methods Patients with three-vessel disease who underwent isolated coronary artery bypass grafting (CABG) in 2006 and received at least one graft to the left anterior descending artery (LAD) or to the first obtuse marginal (OM1) or posterior descending artery (PDA) were included...
April 12, 2017: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/28388824/conservation-strategies-for-understanding-and-combating-the-primate-bushmeat-trade-on-bioko-island-equatorial-guinea
#9
REVIEW
Drew T Cronin, Paul R Sesink Clee, Matthew W Mitchell, Demetrio Bocuma Meñe, David Fernández, Cirilo Riaco, Maximiliano Fero Meñe, Jose Manuel Esara Echube, Gail W Hearn, Mary Katherine Gonder
Bioko Island, Equatorial Guinea is among the important places in Africa for the conservation of primates, but a cultural preference for bushmeat and a lack of effective law enforcement has encouraged commercial bushmeat hunting, threatening the survival of the remaining primate population. For over 13 years, we collected bushmeat market data in the Malabo market, recording over 35,000 primate carcasses, documenting "mardi gras" consumption patterns, seasonal carcass availability, and negative effects resulting from government intervention...
April 7, 2017: American Journal of Primatology
https://www.readbyqxmd.com/read/28387716/a-study-about-regioisomeric-hydroquinones-with-multiple-intramolecular-hydrogen-bonding
#10
Maximiliano Martínez-Cifuentes, Wilson Cardona, Claudio Saitz, Boris Weiss-López, Ramiro Araya-Maturana
A theoretical exploration about hydrogen bonding in a series of synthetic regioisomeric antitumor tricyclic hydroquinones is presented. The stabilization energy for the intramolecular hydrogen bond (IHB) formation in four structurally different situations were evaluated: (a) IHB between the proton of a phenolic hydroxyl group and an ortho-carbonyl group (forming a six-membered ring); (b) between the oxygen atom of a phenolic hydroxyl group and the proton of an hydroxyalkyl group (seven membered ring); (c) between the proton of a phenolic hydroxyl group with the oxygen atom of the hydroxyl group of a hydroxyalkyl moiety (seven-membered ring); and (d) between the proton of a phenolic hydroxyl group and an oxygen atom directly bonded to the aromatic ring in ortho position (five-membered ring)...
April 7, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28379866/editorial-outcome-measures
#11
R Maximiliano Gómez, Henry Milgrom
No abstract text is available yet for this article.
April 4, 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28379210/polymorphism-rs2275913-of-interleukin-17a-is-related-to-more-intensive-therapy-with-disease-modifying-anti-rheumatic-drugs-in-mexican-patients-with-rheumatoid-arthritis
#12
Maximiliano García de la Peña, René Méndez Cruz, Efraín Garrido Guerrero, Aida Galicia López, Glustein Pozo Molina, Norma Estela Herrera González
AIM: The study has two aims: 1) to evaluate the association of IL-17 polymorphism rs2275913 with RA severity and 2) to evaluate if this particular SNP is associated with susceptibility for RA in Mexican patients. METHODS: Seventy-six RA patients and ninety-four healthy controls were included in the study. RA patients were evaluated according to DAS 28. Treatment with DMARD'S was prescribed and radiological damage was evaluated according to the Larsen method. A case-control study was used...
December 21, 2016: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/28375183/experimental-and-theoretical-reduction-potentials-of-some-biologically-active-ortho-carbonyl-para-quinones
#13
Maximiliano Martínez-Cifuentes, Ricardo Salazar, Oney Ramírez-Rodríguez, Boris Weiss-López, Ramiro Araya-Maturana
The rational design of quinones with specific redox properties is an issue of great interest because of their applications in pharmaceutical and material sciences. In this work, the electrochemical behavior of a series of four p-quinones was studied experimentally and theoretically. The first and second one-electron reduction potentials of the quinones were determined using cyclic voltammetry and correlated with those calculated by density functional theory (DFT) using three different functionals, BHandHLYP, M06-2x and PBE0...
April 4, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28364120/lateral-antimicrobial-resistance-genetic-transfer-is-active-in-the-open-environment
#14
Luciana S Chamosa, Verónica E Álvarez, Maximiliano Nardelli, María Paula Quiroga, Marcelo H Cassini, Daniela Centrón
Historically, the environment has been viewed as a passive deposit of antimicrobial resistance mechanisms, where bacteria show biological cost for maintenance of these genes. Thus, in the absence of antimicrobial pressure, it is expected that they disappear from environmental bacterial communities. To test this scenario, we studied native IntI1 functionality of 11 class 1 integron-positive environmental strains of distant genera collected in cold and subtropical forests of Argentina. We found natural competence and successful site-specific insertion with no significant fitness cost of both aadB and bla VIM-2 antimicrobial resistance gene cassettes, in a model system without antibiotic pressure...
March 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28356329/effectors-of-filamentous-plant-pathogens-commonalities-amid-diversity
#15
REVIEW
Marina Franceschetti, Abbas Maqbool, Maximiliano J Jiménez-Dalmaroni, Helen G Pennington, Sophien Kamoun, Mark J Banfield
Fungi and oomycetes are filamentous microorganisms that include a diversity of highly developed pathogens of plants. These are sophisticated modulators of plant processes that secrete an arsenal of effector proteins to target multiple host cell compartments and enable parasitic infection. Genome sequencing revealed complex catalogues of effectors of filamentous pathogens, with some species harboring hundreds of effector genes. Although a large fraction of these effector genes encode secreted proteins with weak or no sequence similarity to known proteins, structural studies have revealed unexpected similarities amid the diversity...
June 2017: Microbiology and Molecular Biology Reviews: MMBR
https://www.readbyqxmd.com/read/28355946/dysexecutive-symptoms-in-primary-progressive-aphasia
#16
Joël Macoir, Monica Lavoie, Robert Laforce, Simona M Brambati, Maximiliano A Wilson
Primary progressive aphasia (PPA) is a heterogeneous neurodegenerative condition in which the most prominent clinical feature is language difficulties. Other cognitive domains have been described to remain unaffected at the early stages of the disease and, therefore, excluded from diagnostic criteria. However, we show in this article that executive function (EF) disorders may be present in the 3 variants (nonfluent/agrammatic, logopenic, and semantic) of PPA. We also illustrate changes in language and EF by means of a 3-year behavioral and neuroimaging longitudinal study of a patient suffering from the semantic variant of PPA...
January 1, 2017: Journal of Geriatric Psychiatry and Neurology
https://www.readbyqxmd.com/read/28353046/corr-insights-%C3%A2-what-influence-does-progression-of-a-nonhealing-rotator-cuff-tear-have-on-shoulder-pain-and-function
#17
Maximiliano Ranalletta
No abstract text is available yet for this article.
March 28, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28347488/targeted-interneuron-depletion-in-the-dorsal-striatum-produces-autism-like-behavioral-abnormalities-in-male-but-not-female-mice
#18
Maximiliano Rapanelli, Luciana Romina Frick, Meiyu Xu, Stephanie Mary Groman, Kantiya Jindachomthong, Nobuaki Tamamaki, Chiyoko Tanahira, Jane Rebecca Taylor, Christopher Pittenger
BACKGROUND: Interneuronal pathology is implicated in many neuropsychiatric disorders, including autism spectrum disorder (ASD) and Tourette syndrome (TS). Interneurons of the striatum, including the parvalbumin-expressing fast-spiking interneurons (FSIs) and the large cholinergic interneurons (CINs), are affected in patients with TS and in preclinical models of both ASD and TS. METHODS: To test the causal importance of these neuronal abnormalities, we recapitulated them in vivo in developmentally normal mice using a combination transgenic-viral strategy for targeted toxin-mediated ablation...
February 10, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28336229/arthroscopic-in-situ-repair-of-partial-bursal-rotator-cuff-tears-without-acromioplasty
#19
Maximiliano Ranalletta, Luciano A Rossi, Nicolas A Atala, Bernardo A B Altieri, Gastón D Maignon, Santiago L Bongiovanni
PURPOSE: To evaluate functional outcomes and complications in a consecutive group of patients with partial bursal rotator cuff tears (PBRCTs) treated with insitu repair without acromioplasty. METHODS: Seventy-four patients who had undergone an arthroscopic single row in situ repair for bursal-sided rotator cuff tears were evaluated. Clinical assessment consisted of glenohumeral range of motion measurement, the American Shoulder and Elbow Surgeons score, and the University of California at Los Angeles score...
March 20, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28314592/reactive-oxygen-species-localization-programs-inflammation-to-clear-microbes-of-different-size
#20
Annika Warnatsch, Theodora-Dorita Tsourouktsoglou, Nora Branzk, Qian Wang, Susanna Reincke, Susanne Herbst, Maximiliano Gutierrez, Venizelos Papayannopoulos
How the number of immune cells recruited to sites of infection is determined and adjusted to differences in the cellular stoichiometry between host and pathogen is unknown. Here, we have uncovered a role for reactive oxygen species (ROS) as sensors of microbe size. By sensing the differential localization of ROS generated in response to microbes of different size, neutrophils tuned their interleukin (IL)-1β expression via the selective oxidation of NF-κB, in order to implement distinct inflammatory programs...
March 21, 2017: Immunity
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