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Anetta Härtlova, Susanne Herbst, Julien Peltier, Angela Rodgers, Orsolya Bilkei-Gorzo, Antony Fearns, Brian D Dill, Heyne Lee, Rowan Flynn, Sally A Cowley, Paul Davies, Patrick A Lewis, Ian G Ganley, Jennifer Martinez, Dario R Alessi, Alastair D Reith, Matthias Trost, Maximiliano G Gutierrez
Mutations in the leucine-rich repeat kinase 2 (LRRK2) are associated with Parkinson's disease, chronic inflammation and mycobacterial infections. Although there is evidence supporting the idea that LRRK2 has an immune function, the cellular function of this kinase is still largely unknown. By using genetic, pharmacological and proteomics approaches, we show that LRRK2 kinase activity negatively regulates phagosome maturation via the recruitment of the Class III phosphatidylinositol-3 kinase complex and Rubicon to the phagosome in macrophages...
May 22, 2018: EMBO Journal
Luis A Serrano, Maximiliano J Fornerod, Ye Yang, Simon Gaisford, Francesco Stellacci, Stefan Guldin
Herein, we report on the phase behaviour of a binary liquid mixture composed of methanol (MeOH) and the thermotropic liquid crystal 4-cyano-4'-pentylbiphenyl (5CB). The corresponding phase diagram combines features of a conventional liquid-liquid mixture with characteristics that are particular to the nematic liquid crystal. We observe four arrangements as a function of composition and temperature, namely monophasic isotropic, monophasic nematic, biphasic isotropic-isotropic and biphasic isotropic-nematic, with an upper critical solution temperature of 24...
May 22, 2018: Soft Matter
Fareeha Batool, Marion Strub, Catherine Petit, Isaac Maximiliano Bugueno, Fabien Bornert, François Clauss, Olivier Huck, Sabine Kuchler-Bopp, Nadia Benkirane-Jessel
This review encompasses different pre-clinical bioengineering approaches for periodontal tissues, maxillary jaw bone, and the entire tooth. Moreover, it sheds light on their potential clinical therapeutic applications in the field of regenerative medicine. Herein, the electrospinning method for the synthesis of polycaprolactone (PCL) membranes, that are capable of mimicking the extracellular matrix (ECM), has been described. Furthermore, their functionalization with cyclosporine A (CsA), bone morphogenetic protein-2 (BMP-2), or anti-inflammatory drugs' nanoreservoirs has been demonstrated to induce a localized and targeted action of these molecules after implantation in the maxillary jaw bone...
May 16, 2018: Nanomaterials
Maximiliano J Garzón, Nicolás Schweigmann
BACKGROUND: Gene flow restrictions between populations of Aedes albifasciatus, the vector of Western equine encephalitis and Dirophilaria immitis, have been described in the central region of Argentina. Genetic and eco-physiological variations usually result in local forms reflecting the climatic regions. Mosquito wings and their different parts have ecological functions in flight and communication. Therefore, wing shape could be considered an aspect of sexual dimorphism, and its eco-physiological responses can be expressed as morphological changes induced by the environment...
May 16, 2018: Parasites & Vectors
Maximiliano J Amenabar, Daniel R Colman, Saroj Poudel, Eric E Roden, Eric S Boyd
The thermoacidophilic Acidianus strain DS80 displays versatility in its energy metabolism and can grow autotrophically and heterotrophically with elemental sulfur (S°), ferric iron (Fe3+ ), or oxygen (O2 ) as electron acceptors. Here we show that autotrophic and heterotrophic growth with S° as the electron acceptor is obligately dependent on hydrogen (H2 ) as electron donor; organic substrates such as acetate can only serve as a carbon source. In contrast, organic substrates such as acetate can serve as electron donor and carbon source for Fe3+ or O2 grown cells...
May 11, 2018: Environmental Microbiology
Joana Borlido, Stephen Sakuma, Marcela Raices, Florent Carrette, Roberto Tinoco, Linda M Bradley, Maximiliano A D'Angelo
Nuclear pore complexes (NPCs) are channels connecting the nucleus with the cytoplasm. We report that loss of the tissue-specific NPC component Nup210 causes a severe deficit of naïve CD4+ T cells. Nup210-deficient CD4+ T lymphocytes develop normally but fail to survive in the periphery. The decreased survival results from both an impaired ability to transmit tonic T cell receptor (TCR) signals and increased levels of Fas, which sensitize Nup210-/- naïve CD4+ T cells to Fas-mediated cell death. Mechanistically, Nup210 regulates these processes by modulating the expression of Cav2 (encoding Caveolin-2) and Jun at the nuclear periphery...
May 7, 2018: Nature Immunology
Alexandre St-Hilaire, Camille Parent, Olivier Potvin, Louis Bherer, Jean-François Gagnon, Sven Joubert, Sylvie Belleville, Maximiliano A Wilson, Lisa Koski, Isabelle Rouleau, Carol Hudon, Joël Macoir
OBJECTIVE: The Trail Making Test (TMT) is mainly used to assess visual scanning/processing speed (part A) and executive functions (part B). The test has proven sensitive at detecting cognitive impairment during aging. However, previous studies have shown differences between normative data from different countries and cultures, even when corrected for age and education. Such inconsistencies between normative data may lead to serious diagnostic errors, thus, the development of local norms is warranted...
May 4, 2018: Clinical Neuropsychologist
Linda Mahjoubi, Fabiola Cecchi, Christophe Massard, Fabio Calabro, Anas Gazzah, Rastislav Bahleda, Philippe Jamme, Maximiliano Gelli, Diane Goere, Ludovic Lacroix, Julien Adam, Lukas Heukamp, Patrizia Trenta, Todd Hembrough, Jean-Charles Soria, Cora Sternberg, Michel Ducreux
INTRODUCTION: Diffuse gastric cancer is associated with poor prognosis. We report a patient with metastatic gastric linitis plastica harboring human epidermal growth factor receptor 2 ( HER2) activating mutation and HER2 amplification. CASE DESCRIPTION: The patient received 5-fluorouracil/folinic acid and oxaliplatin combined with trastuzumab/pertuzumab, resulting in disease control for 8 months. Second-line therapy with nivolumab and trastuzumab/pertuzumab was well-tolerated, with macroscopic peritoneal response...
March 1, 2018: Tumori
Nelly Rivera-Yañez, Mario Rodriguez-Canales, Oscar Nieto-Yañez, Manuel Jimenez-Estrada, Maximiliano Ibarra-Barajas, M M Canales-Martinez, M A Rodriguez-Monroy
Propolis is a bee-collected natural product that has been proven to have various bioactivities. This study tested the effects of a Mexican propolis on streptozotocin-induced diabetes mellitus in a murine model. The results showed that an ethanolic extract of propolis of Chihuahua (EEPCh) significantly inhibited increases in blood glucose and the loss of body weight in diabetic mice. EEPCh increased plasma insulin levels in STZ-diabetic mice, whereas, in untreated diabetic mice, there was no detection of insulin...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Pradeep Lal, Hideyuki Tanabe, Maximiliano L Suster, Deepak Ailani, Yuri Kotani, Akira Muto, Mari Itoh, Miki Iwasaki, Hironori Wada, Emre Yaksi, Koichi Kawakami
BACKGROUND: Fear conditioning is a form of learning essential for animal survival and used as a behavioral paradigm to study the mechanisms of learning and memory. In mammals, the amygdala plays a crucial role in fear conditioning. In teleost, the medial zone of the dorsal telencephalon (Dm) has been postulated to be a homolog of the mammalian amygdala by anatomical and ablation studies, showing a role in conditioned avoidance response. However, the neuronal populations required for a conditioned avoidance response via the Dm have not been functionally or genetically defined...
April 25, 2018: BMC Biology
Walter F Tetzlaff, Tomás Meroño, Eliana E Botta, Maximiliano E Martín, Patricia B Sorroche, Laura E Boero, Marcelo Castro, Gustavo D Frechtel, Jorge Rey, Jorge Daruich, Gloria E Cerrone, Fernando Brites
Primary iron overload (IO) is commonly associated with mutations in the hereditary hemochromatosis gene (HFE). Nonetheless, other genetic variants may influence the development of IO beyond HFE mutations. There is a single nucleotide polymorphism (SNP) at - 174 G>C of the interleukin (IL)-6 gene which might be associated with primary IO. Our aim was to study the association between the SNP - 174 G>C gene promoter of IL-6 and primary IO in middle-aged male patients. We studied 37 men with primary IO diagnosed by liver histology...
April 14, 2018: Annals of Hematology
Fareeha Batool, David-Nicolas Morand, Lionel Thomas, Isaac Maximiliano Bugueno, Javier Aragon, Silvia Irusta, Laetitia Keller, Nadia Benkirane-Jessel, Henri Tenenbaum, Olivier Huck
Ibuprofen (IBU) has been shown to improve periodontal treatment outcomes. The aim of this study was to develop a new anti-inflammatory scaffold by functionalizing an electrospun nanofibrous poly-ε-caprolactone membrane with IBU (IBU-PCL) and to evaluate its impact on periodontal inflammation, wound healing and regeneration in vitro and in vivo. IBU-PCL was synthesized through electrospinning. The effects of IBU-PCL on the proliferation and migration of epithelial cells (EC) and fibroblasts (FB) exposed to Porphyromonas gingivlais lipopolysaccharide (Pg -LPS) were evaluated through the AlamarBlue test and scratch assay, respectively...
April 10, 2018: Materials
Danielle Zacaron Santos, Isabel Cristina Gonçalves Leite, Maximiliano Ribeiro Guerra
PURPOSE: This prospective study was conducted to evaluate the functional status and clinical features of inpatients with metastatic spinal cord compression and to explore possible associated factors and the correlation with neurological deficits. METHODS: Cases were identified through an active search in the hospital units of the National Cancer Institute. For 47 patients, clinical and demographic characteristics were collected; functional status was measured by the Functional Independence Measure; modified Tokuhashi score was used to predict survival time; neurological deficits were measured using the American Spinal Injury Association Impairment Scale; and general condition was evaluated using the Karnofsky Performance Status Scale...
April 6, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Maximiliano J Amenabar, Eric S Boyd
The thermoacidophile Acidianus is widely distributed in Yellowstone National Park hot springs that span large gradients in pH (1.60 to 4.84), temperature (42 to 90°C), and mineralogical composition. To characterize the potential role of flexibility in mineral-dependent energy metabolism in contributing to the widespread ecological distribution of this strain, we characterized the spectrum of minerals capable of supporting metabolism and mechanisms that the strain uses to access these minerals. The energy metabolism of Acidianus strain DS80 was supported by elemental sulfur (S°), a variety of iron (hydr)oxides, and arsenic sulfide...
April 6, 2018: Applied and Environmental Microbiology
Roberta de Paula Martins, Viviane Glaser, Aderbal S Aguiar, Priscila Maximiliano de Paula Ferreira, Karina Ghisoni, Débora da Luz Scheffer, Laurence Lanfumey, Rita Raisman-Vozari, Olga Corti, Ana Lucia De Paul, Rodrigo Augusto da Silva, Alexandra Latini
Parkinson's disease (PD), the second-most prevalent neurodegenerative disease, is primarily characterized by neurodegeneration in the substantia nigra pars compacta, resulting in motor impairment. Loss-of-function mutations in parkin are the major cause of the early-onset familial form of the disease. Although rodents deficient in parkin (parkin(-/-)) have some dopaminergic system dysfunction associated with central oxidative stress and energy metabolism deficiencies, these animals only display nigrostriatal pathway degeneration under inflammatory conditions...
April 6, 2018: Cell Biology International
Maximiliano G Gutierrez, Jeremy G Carlton
No abstract text is available yet for this article.
April 6, 2018: Science
Giulio Maltoni, Maximiliano Zioutas, Stefano Zucchini, Andrea Pession
Basal-bolus regimen is the best treatment for children with type 1 diabetes (T1D), but requires several insulin injections a day1 . In fact, the body's physical growth, the management of frequent snacks and mistakes in carb-counting and in insulin boluses require the ability to promptly adapt insulin scheme2,3 .
March 31, 2018: Journal of Diabetes
Miriam Cortés-Rodriguez, Jose-Luis Royo, Arturo Reyes-Palomares, Ana M Lendínez, Maximiliano Ruiz-Galdón, Armando Reyes-Engel
Spermatozoa and neurones share similar membrane characteristics and features. Associations of multiple polymorphisms traditionally related to neurotransmission were investigated. Infertile men were grouped into controls with normospermia (n = 182) and idiopathic infertile men with asthenozoospermia (n = 103), and analysed as a case-control study and as a quantitative association of each genotype. Ten neurotransmission-associated genetic variants were mapped by SNP analysis using quantitative polymerase chain reaction with TaqMan probes...
February 2, 2018: Reproductive Biomedicine Online
M Antonela Zígolo, Maximiliano Salinas, Laura Alché, Alicia Baldessari, Guadalupe García Liñares
We present an efficient approach to the synthesis of a series of glycyrrhetinic acid derivatives. Six derivatives, five of them new compounds, were obtained through chemoenzymatic reactions in very good to excellent yield. In order to find the optimal reaction conditions, the influence of various parameters such as enzyme source, nucleophile:substrate ratio, enzyme:substrate ratio, solvent and temperature was studied. The excellent results obtained by lipase catalysis made the procedure very efficient considering their advantages such as mild reaction conditions and low environmental impact...
March 19, 2018: Bioorganic Chemistry
Francisco J Carvajal, Rodrigo G Mira, Maximiliano Rovegno, Alicia N Minniti, Waldo Cerpa
Oxidative stress affects the survival and function of neurons. Hence, they have a complex and highly regulated machinery to handle oxidative changes. The dysregulation of this antioxidant machinery is associated with a wide range of neurodegenerative conditions. Therefore, we evaluated signaling alterations, synaptic properties and behavioral performance in 2 and 6-month-old heterozygous manganese superoxide dismutase knockout mice (SOD2+/- mice). We found that their low antioxidant capacity generated direct oxidative damage in proteins, lipids, and DNA...
March 22, 2018: Biochimica et Biophysica Acta
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