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https://www.readbyqxmd.com/read/27905650/-aseptic-techniques-for-minor-surgical-procedures
#1
Marcela Concha-Rogazy, Catalina Andrighetti-Ferrada, Maximiliano Curi-Tuma
Aseptic techniques are those practices designed to reduce the risk of surgical site infection (SSI), defined as such, all those that occur within the first 30 days of the procedure. While the patient’s risk of developing an SSI in dermatologic surgery is low since many of the procedures are considered sterile, there are different factors associated with an increased or decreased risk of developing SSI. The characteristics of the surgical wound (such as involving infected or inflamed tissue or when breaks in the aseptic technique occur), patient characteristics (such as age, comorbidities, medication use and smoking) and procedure factors (such as setting, surgical technique, type of procedure, duration and body region involved)...
August 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/27901250/perception-of-stroke-symptoms-and-utilization-of-emergency-medical-services
#2
Maximiliano A Hawkes, Mauricio F Farez, Ismael L Calandri, Sebastián F Ameriso
Methods: Review of hospital records and structured telephone interviews of 100 consecutive stroke patients. Forward stepwise logistic regression was used for the statistical analysis. Results: Seventy patients (75%) arrived at the hospital 4.5 hours after stroke symptoms onset. The use of EMS did not improve arrival times. Most patients who recognized their symptoms did not use EMS (p < 0.02). Nineteen patients (20%) were initially misdiagnosed. Eighteen of them were first assessed by non-neurologist physicians (p < 0...
November 2016: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/27891029/craniovertebral-junction-360%C3%A2-a-combined-microscopic-and-endoscopic-anatomical-study
#3
Sukhdeep Singh Jhawar, Maximiliano Nunez, Paolo Pacca, Daniel Seclen Voscoboinik, Huy Truong
OBJECTIVES: Craniovertebral junction (CVJ) can be approached from various corridors depending on the location and extent of disease. A three-dimensional understanding of anatomy of CVJ is paramount for safe surgery in this region. Aim of this cadaveric study is to elucidate combined microscopic and endoscopic anatomy of critical neurovascular structures in this area in relation to bony and muscular landmarks. MATERIALS AND METHODS: Eight fresh-frozen cadaveric heads injected with color silicon were used for this study...
October 2016: Journal of Craniovertebral Junction and Spine
https://www.readbyqxmd.com/read/27890669/doxorubicin-nanotechnological-overviews-from-bench-to-bedside
#4
REVIEW
Maximiliano Cagel, Estefanía Grotz, Ezequiel Bernabeu, Marcela A Moretton, Diego A Chiappetta
Doxorubicin (DOX) is considered one of the most effective chemotherapeutic agents, used as a first-line drug in numerous types of cancer. Nevertheless, it exhibits serious adverse effects, such as lethal cardiotoxicity and dose-limiting myelosuppression. In this review, we focus on the description and the clinical benefits of different DOX-loaded nanotechnological platforms, not only those commercially available but also the ones that are currently in clinical phases, such as liposomes, polymeric nanoparticles, polymer-drug conjugates, polymeric micelles and ligand-based DOX-loaded nanoformulations...
November 23, 2016: Drug Discovery Today
https://www.readbyqxmd.com/read/27876436/targeted-brain-delivery-nanoparticles-for-malignant-gliomas
#5
Mauricio P Pinto, Maximiliano Arce, Basit Yameen, Cristian Vilos
Brain tumors display the highest mortality rates of all childhood cancers, and over the last decade its prevalence has steadily increased in elderly. To date, effective treatments for brain tumors and particularly for malignant gliomas remain a challenge mainly due to the low permeability and high selectivity of the blood-brain barrier (BBB) to conventional anticancer drugs. In recent years, the elucidation of the cellular mechanisms involved in the transport of substances into the brain has boosted the development of therapeutic-targeted nanoparticles (NPs) with the ability to cross the BBB...
November 23, 2016: Nanomedicine
https://www.readbyqxmd.com/read/27875793/detection-and-quantification-of-aggregatibacter-actinomycetemcomitans-porphyromonas-gingivalis-and-streptococcus-oralis-in-blood-samples-with-different-microbiological-identification-methods-an-in-vitro-study
#6
María José Marin, Nagore Ambrosio, Leire Virto, Pedro Diz, Maximiliano Álvarez, David Herrera, Mariano Sanz, Elena Figuero
BACKGROUND: Culture-based methods (culture broth bottles or lysis methods) have been the standard for detecting bacteremia. More recently, quantitative polymerase chain reaction (qPCR) was proposed as a more sensitive and specific test although none of them has been validated for the identification of periodontal pathogens (fastidious growing bacteria) in blood samples. OBJECTIVE: To compare the ability to detect and quantify Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis and Streptococcus oralis (alone or in combination) in blood samples with three culture techniques [direct anaerobic culturing (DAC), haemo-culture (BACTEC), and lysis-centrifugation (LC)] and a non-culture dependent approach (qPCR) in an in vitro study...
November 9, 2016: Archives of Oral Biology
https://www.readbyqxmd.com/read/27869957/mental-disorders-record-on-the-brazilian-primary-health-care-information-system-2014
#7
Maximiliano Loiola Ponte de Souza
OBJECTIVE: to describe the occurrence of the recording of mental disorders (MD) in primary health care (PHC) services in Brazilian municipalities and to analyze associated factors. METHODS: an ecological study was conducted using PHC Information System secondary data for the year 2014; the magnitude of the occurrence of MD recording was assessed through indicators developed for this purpose; bivariate analysis was used. RESULTS: 15,216 MD cases were recorded in 42 (0...
April 2016: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://www.readbyqxmd.com/read/27866795/midterm-outcomes-after-arthroscopic-anteroinferior-capsular-release-for-the-treatment-of-idiophatic-adhesive-capsulitis
#8
Maximiliano Ranalletta, Luciano Andrés Rossi, Ezequiel Ernesto Zaidenberg, Carlos Campos, Tanoira Ignacio, Gastón Daniel Maignon, Santiago Luis Bongiovanni
PURPOSE: The purpose of this study is to report the early and midterm functional outcomes and complications of a consecutive series of patients with primary adhesive capsulitis who were treated with isolated anteroinferior arthroscopic capsular release after they did not respond to conservative treatment. METHODS: Thirty-two consecutive patients with idiopathic adhesive capsulitis who did not respond to conservative physiotherapy were included in the study. Arthroscopic anteroinferior capsular release was performed in all cases...
November 17, 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/27858925/-dermatomyositis-as-the-first-manifestation-of-small-cell-carcinoma-case-report-and-literature-review
#9
Herman Ahumada Piña, Luis Fuentes Cabrera, Rodrigo Selamé Glena, Daniel García Oneto, Andrea Jiménez Aguilar, Claudia Durán Herrera, Jorge Ávila Pérez, Maximiliano Cortés Latorre
Dermatomyositis is an autoimmune inflammatory myopathy associated with dermatologic findings. Its association with neoplasms is widely reported and has been shown to be higher in lung cancer, particularly small-cell carcinoma, probably as it originates from neuroendocrine cell precursors, as well as breast and ovarian cancer. The low frequency of dermatomyositis makes it difficult to suspect the underlying lesions among the diagnostic possibilities of systemic diseases with cutaneous manifestations. Therefore, the high probability of a neoplasm should always be considered, with reports of up to 75% in the eastern population and about 40% in general...
November 15, 2016: Medwave
https://www.readbyqxmd.com/read/27849128/when-the-wedding-march-becomes-sad-semantic-memory-impairment-for-music-in-the-semantic-variant-of-primary-progressive-aphasia
#10
Joël Macoir, Sarah Berubé-Lalancette, Maximiliano A Wilson, Robert Laforce, Carol Hudon, Pierre Gravel, Olivier Potvin, Simon Duchesne, Laura Monetta
Music can induce particular emotions and activate semantic knowledge. In the semantic variant of primary progressive aphasia (svPPA), semantic memory is impaired as a result of anterior temporal lobe (ATL) atrophy. Semantics is responsible for the encoding and retrieval of factual knowledge about music, including associative and emotional attributes. In the present study, we report the performance of two individuals with svPPA in three experiments. NG with bilateral ATL atrophy and ND with atrophy largely restricted to the left ATL...
November 16, 2016: Neurocase
https://www.readbyqxmd.com/read/27848088/corr-insights-%C3%A2-high-irritation-and-removal-rates-after-plate-or-nail-fixation-in-patients-with-displaced-midshaft-clavicle-fractures
#11
Maximiliano Ranalletta
No abstract text is available yet for this article.
November 15, 2016: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/27826596/return-to-sports-after-arthroscopic-treatment-of-rotator-cuff-calcifications-in-athletes
#12
Maximiliano Ranalletta, Luciano A Rossi, Adrian Sirio, Guillermina Bruchmann, Gastón D Maignon, Santiago L Bongiovanni
BACKGROUND: Arthroscopic treatment of calcific deposits of rotator cuff tears has been described with successful results in the general population. However, despite the high frequency of this condition, there is no information in the literature regarding arthroscopic treatment of rotator cuff calcifications in athletes. PURPOSE: To analyze the time to return to sport, clinical outcomes, and complications of complete arthroscopic removal of intratendinous calcific deposits and repair of the tendon lesion without acromioplasty in athletes...
October 2016: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/27820825/bottom-up-assembly-of-the-phytochrome-network
#13
Maximiliano Sánchez-Lamas, Christian D Lorenzo, Pablo D Cerdán
Plants have developed sophisticated systems to monitor and rapidly acclimate to environmental fluctuations. Light is an essential source of environmental information throughout the plant's life cycle. The model plant Arabidopsis thaliana possesses five phytochromes (phyA-phyE) with important roles in germination, seedling establishment, shade avoidance, and flowering. However, our understanding of the phytochrome signaling network is incomplete, and little is known about the individual roles of phytochromes and how they function cooperatively to mediate light responses...
November 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27819529/developability-of-biotherapeutics-computational-approaches-edited-by-sandeep-kumar-and-satish-k-singh
#14
Charlotte M Deane, Maximiliano Vásquez
No abstract text is available yet for this article.
November 7, 2016: MAbs
https://www.readbyqxmd.com/read/27816654/bioactivity-of-an-antihypertensive-peptide-expressed-in-chlamydomonas-reinhardtii
#15
Celma Estefanía Ochoa-Méndez, Ignacio Lara-Hernández, Luzmila Martínez González, Patricia Aguirre-Bañuelos, Maximiliano Ibarra-Barajas, Patricia Castro-Moreno, Omar González-Ortega, Ruth Elena Soria-Guerra
In this study, we developed a transplastomic C. reinhardtii strain that accumulates anti-hypertensive peptides. Tandem repeats of VLPVP peptide were included. PCR analysis confirmed the presence of the transgene in the modified strains. After in vitro digestion of biomass of a recombinant C. reinhardtii strain the VLVPV peptide was identified and quantified by HPLC. The highest expression line produced 0.292mg of recombinant protein per mg of freeze-dried biomass. Intragastric administration of the genetically modified strain to spontaneous hypertensive rats at a dose of 30mg/kg of body weight of recombinant protein significantly reduced systolic blood pressure...
November 2, 2016: Journal of Biotechnology
https://www.readbyqxmd.com/read/27815879/quantitative-spatiotemporal-analysis-of-phagosome-maturation-in-live-cells
#16
Laura Schnettger, Maximiliano G Gutierrez
Phagocytosis and phagosome maturation are central to the development of the innate and adaptive immune response. Phagosome maturation is a continuous and dynamic process that occurs rapidly. In this chapter, we describe fluorescence-based live cell imaging methods for the quantitative and temporal analysis of phagosome maturation of latex beads and M. tuberculosis as two phagocytic targets. We also describe two simple protocols for monitoring phagosome maturation: the use of the acidotropic probe LysoTracker and analyzing the recruitment of EGFP-tagged host proteins by phagosomes...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27801880/evidence-of-the-disassembly-of-%C3%AE-cyclodextrin-octylamine-inclusion-compounds-conjugated-to-gold-nanoparticles-via-thermal-and-photothermal-effects
#17
Nataly Silva, Silvana Moris, Maximiliano Díaz, Nicolás Yutronic, Erika Lang, Boris Chornik, Marcelo J Kogan, Paul Jara
Cyclodextrin (CD) molecules form inclusion compounds (ICs), generating dimers that are capable of encapsulating molecules derived from long-chain hydrocarbons. The aim of this study is to evaluate the structural changes experienced by ICs in solution with increasing temperatures. For this, a nuclear magnetic resonance (¹H-NMR) titration was performed to determinate the stoichiometric α-cyclodextrin (α-CD):octylamine (OA) 2:1 and binding constant (k = 2.16 M(-2)) of ICs. Solution samples of α-CD-OA ICs conjugated with gold nanoparticles (AuNPs) were prepared, and ¹H-NMR spectra at different temperatures were recorded...
October 29, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27789798/phytochrome-b-integrates-light-and-temperature-signals-in-arabidopsis
#18
Martina Legris, Cornelia Klose, E Sethe Burgie, Cecilia Costigliolo, Maximiliano Neme, Andreas Hiltbrunner, Philip A Wigge, Eberhard Schäfer, Richard D Vierstra, Jorge J Casal
Ambient temperature regulates many aspects of plant growth and development but its sensors are unknown. Here, we demonstrate that the phytochrome B (phyB) photoreceptor participates in temperature perception through its temperature-dependent reversion from the active Pfr state to the inactive Pr state. Increased rates of thermal reversion upon exposing Arabidopsis seedlings to warm environments reduce both the abundance of the biologically active Pfr-Pfr dimer pool of phyB and the size of the associated nuclear bodies, even in daylight...
October 27, 2016: Science
https://www.readbyqxmd.com/read/27777642/risk-and-safety-requirements-for-diagnostic-and-therapeutic-procedures-in-allergology-world-allergy-organization-statement
#19
Marek L Kowalski, Ignacio Ansotegui, Werner Aberer, Mona Al-Ahmad, Mubeccel Akdis, Barbara K Ballmer-Weber, Kirsten Beyer, Miguel Blanca, Simon Brown, Chaweewan Bunnag, Arnaldo Capriles Hulett, Mariana Castells, Hiok Hee Chng, Frederic De Blay, Motohiro Ebisawa, Stanley Fineman, David B K Golden, Tari Haahtela, Michael Kaliner, Connie Katelaris, Bee Wah Lee, Joanna Makowska, Ulrich Muller, Joaquim Mullol, John Oppenheimer, Hae-Sim Park, James Parkerson, Giovanni Passalacqua, Ruby Pawankar, Harald Renz, Franziska Rueff, Mario Sanchez-Borges, Joaquin Sastre, Glenis Scadding, Scott Sicherer, Pongsakorn Tantilipikorn, James Tracy, Vera van Kempen, Barbara Bohle, G Walter Canonica, Luis Caraballo, Maximiliano Gomez, Komei Ito, Erika Jensen-Jarolim, Mark Larche, Giovanni Melioli, Lars K Poulsen, Rudolf Valenta, Torsten Zuberbier
One of the major concerns in the practice of allergy is related to the safety of procedures for the diagnosis and treatment of allergic disease. Management (diagnosis and treatment) of hypersensitivity disorders involves often intentional exposure to potentially allergenic substances (during skin testing), deliberate induction in the office of allergic symptoms to offending compounds (provocation tests) or intentional application of potentially dangerous substances (allergy vaccine) to sensitized patients. These situations may be associated with a significant risk of unwanted, excessive or even dangerous reactions, which in many instances cannot be completely avoided...
2016: World Allergy Organization Journal
https://www.readbyqxmd.com/read/27773554/the-magnificent-two-histamine-and-the-h3-receptor-as-key-modulators-of-striatal-circuitry
#20
Maximiliano Rapanelli
Histaminergic dysfunction has been recently linked to tic disorders and to aberrant striatal function. There is a particular interest in the histamine 3 receptor (H3R) due to its clinical implications for treating multiple disorders and its high expression in the brain. Striatal histamine (HA) modulates through the H3R in complex ways the release of striatal neurotransmitters into this brain region. The H3R has been classically described to be coupled to Gi, although there is evidence that revealed that striatal H3R forms heteromers with the dopamine receptors 1 and 2 in the medium spiny neurons (MSNs) than changes this signaling...
February 6, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
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