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https://www.readbyqxmd.com/read/28098793/osteocyte-alterations-induce-osteoclastogenesis-in-an-in-vitro-model-of-gaucher-disease
#1
Constanza Bondar, Maximiliano Ormazabal, Andrea Crivaro, Malena Ferreyra-Compagnucci, María Victoria Delpino, Paula Adriana Rozenfeld, Juan Marcos Mucci
Gaucher disease (GD) is caused by mutations in the glucosylceramidase β (GBA 1) gene that confer a deficient level of activity of glucocerebrosidase (GCase). This deficiency leads to the accumulation of the glycolipid glucocerebroside in the lysosomes of cells, mainly in the monocyte/macrophage lineage. Its mildest form is Type I GD, characterized by non-neuronopathic involvement. Bone compromise is the most disabling aspect of the Gaucher disease. However, the pathophysiological aspects of skeletal alterations are not yet fully understood...
January 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28096333/biophysical-properties-of-the-clinical-stage-antibody-landscape
#2
Tushar Jain, Tingwan Sun, Stéphanie Durand, Amy Hall, Nga Rewa Houston, Juergen H Nett, Beth Sharkey, Beata Bobrowicz, Isabelle Caffry, Yao Yu, Yuan Cao, Heather Lynaugh, Michael Brown, Hemanta Baruah, Laura T Gray, Eric M Krauland, Yingda Xu, Maximiliano Vásquez, K Dane Wittrup
Antibodies are a highly successful class of biological drugs, with over 50 such molecules approved for therapeutic use and hundreds more currently in clinical development. Improvements in technology for the discovery and optimization of high-potency antibodies have greatly increased the chances for finding binding molecules with desired biological properties; however, achieving drug-like properties at the same time is an additional requirement that is receiving increased attention. In this work, we attempt to quantify the historical limits of acceptability for multiple biophysical metrics of "developability...
January 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28088069/nuclear-pore-complexes-and-regulation-of-gene-expression
#3
REVIEW
Marcela Raices, Maximiliano A D'Angelo
Nuclear pore complexes (NPCs), are large multiprotein channels that penetrate the nuclear envelope connecting the nucleus to the cytoplasm. Accumulating evidence shows that besides their main role in regulating the exchange of molecules between these two compartments, NPCs and their components also play important transport-independent roles, including gene expression regulation, chromatin organization, DNA repair, RNA processing and quality control, and cell cycle control. Here, we will describe the recent findings about the role of these structures in the regulation of gene expression...
January 11, 2017: Current Opinion in Cell Biology
https://www.readbyqxmd.com/read/28087380/polymeric-mixed-micelles-as-nanomedicines-achievements-and-perspectives
#4
REVIEW
Maximiliano Cagel, Fiorella C Tesan, Ezequiel Bernabeu, Maria J Salgueiro, Marcela B Zubillaga, Marcela A Moretton, Diego A Chiappetta
During the past few decades, polymeric micelles have raised special attention as novel nano-sized drug delivery systems for optimizing the treatment and diagnosis of numerous diseases. These nanocarriers exhibit several in vitro and in vivo advantages as well as increased stability and solubility to hydrophobic drugs. An interesting approach for optimizing these properties and overcoming some of their disadvantages is the combination of two or more polymers in order to assemble polymeric mixed micelles. This review article gives an overview on the current state of the art of several mixed micellar formulations as nanocarriers for drugs and imaging probes, evaluating their ongoing status (preclinical or clinical stage), with special emphasis on type of copolymers, physicochemical properties, in vivo progress achieved so far and toxicity profiles...
January 10, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28076590/effect-of-maternal-exercises-on-biophysical-fetal-and-maternal-parameters-a-transversal-study
#5
Caroline Mombaque Dos Santos, Wendel Mombaque Dos Santos, Francisco Maximiliano Pancich Gallarreta, Camila Pigatto, Luiz Osório Cruz Portela, Edson Nunes de Morais
Objective: To evaluate the acute effects of maternal and fetal hemodynamic responses in pregnant women submitted to fetal Doppler and an aerobic physical exercise test according to the degree of effort during the activity and the impact on the well-being. Methods: Transversal study with low risk pregnant women, obtained by convenience sample with gestational age between 26 to 34 weeks. The participants carry out a progressive exercise test. Results: After the exercise session, reduced resistance (p=0...
October 2016: Einstein
https://www.readbyqxmd.com/read/28052691/strategies-to-prevent-peritoneal-carcinomatosis-arising-from-colorectal-cancer
#6
Maximiliano Gelli, Janina Fl Hugueinin, Cecilia Cerebelli, Léonor Benhaim, Charles Honoré, Dominique Elias, Diane Goéré
In the last decades, cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy became a curative option for peritoneal metastases in selected patients, otherwise considered for palliative therapy alone. Better knowledge of physiopathology of peritoneal spread and identification of predictive factors for peritoneal relapse prompted specialized centers to investigate the role of a 'proactive approach' in order to early detect peritoneal metastasis. These encouraging data could justify an active attitude in selected patients at high risk of peritoneal recurrence after curative resection of primary tumor...
January 5, 2017: Future Oncology
https://www.readbyqxmd.com/read/28031550/bug-smash-bug-splash-a-case-report-of-an-unusual-transmission-of-american-trypanosomiasis-with-a-brief-review-of-the-literature
#7
Rafael Hernán Navarrete-Sandoval, Maximiliano Servín-Rojas
BACKGROUND Chagas disease is a chronic parasitosis transmitted by the inoculation of infected triatomine feces into wounds or conjunctival sac, transfusion, congenitally, organ transplantation, and ingestion of contaminated food. The disease is classified into an acute and chronic phase; the latter is a life-long infection that can be asymptomatic or progress to cardiac or digestive complications. CASE REPORT We report a case of acute-phase Chagas disease, transmitted by the splash of gut content from an infected triatomine into the conjunctival mucosa...
December 29, 2016: American Journal of Case Reports
https://www.readbyqxmd.com/read/28031264/mycobacterium-bovis-requires-p27-lprg-to-arrest-phagosome-maturation-and-replicate-within-bovine-macrophages
#8
Cristina Lourdes Vázquez, María Verónica Bianco, Federico Carlos Blanco, Marina Forrellad, Maximiliano Gabriel Gutierrez, Fabiana Bigi
Mycobacterium bovis causes tuberculosis in a wide variety of mammals with strong tropism for cattle and eventually humans. P27, also called LprG, is among the proteins involved in the mechanisms of virulence and persistence of M. bovis and Mycobacterium tuberculosis Here, we describe a novel function of P27 in the interaction of M. bovis with its natural host cell, the bovine macrophage. We found that a deletion in the p27-p55 operon impairs the replication of M. bovis in bovine macrophages. Importantly, we show for the first time that M...
December 28, 2016: Infection and Immunity
https://www.readbyqxmd.com/read/28024140/do-branched-chain-amino-acids-improve-hepatic-encephalopathy-in-cirrhosis
#9
Maximiliano Vergara, Victoria Castro-Gutiérrez, Gabriel Rada
There is controversy about the effectiveness of branched chain amino acids for treatment of hepatic encephalopathy. Searching in Epistemonikos database, which is maintained by screening multiple databases, we identified seven systematic reviews including 32 randomized controlled trials, of which 30 address the question of this article. We extracted results, combined the evidence using meta-analysis and generated a summary of findings following the GRADE approach. We concluded branched chain amino acids might improve hepatic encephalopathy, but they probably lead to little or no effect on mortality...
December 14, 2016: Medwave
https://www.readbyqxmd.com/read/27993187/hibernation-for-space-travel-impact-on-radioprotection
#10
REVIEW
Matteo Cerri, Walter Tinganelli, Matteo Negrini, Alexander Helm, Emanuele Scifoni, Francesco Tommasino, Maximiliano Sioli, Antonio Zoccoli, Marco Durante
Hibernation is a state of reduced metabolic activity used by some animals to survive in harsh environmental conditions. The idea of exploiting hibernation for space exploration has been proposed many years ago, but in recent years it is becoming more realistic, thanks to the introduction of specific methods to induce hibernation-like conditions (synthetic torpor) in non-hibernating animals. In addition to the expected advantages in long-term exploratory-class missions in terms of resource consumptions, aging, and psychology, hibernation may provide protection from cosmic radiation damage to the crew...
November 2016: Life Sciences in Space Research
https://www.readbyqxmd.com/read/27992569/interleukin-33-and-rank-l-interplay-in-the-alveolar-bone-loss-associated-to-periodontitis
#11
Olivier Lapérine, Alexandra Cloitre, Jocelyne Caillon, Olivier Huck, Isaac Maximiliano Bugueno, Paul Pilet, Sophie Sourice, Elodie Le Tilly, Gaby Palmer, Jean-Luc Davideau, Valérie Geoffroy, Jérôme Guicheux, Sarah Beck-Cormier, Philippe Lesclous
INTRODUCTION: Chronic Periodontitis (CP) is an inflammatory disease of bacterial origin that results in alveolar bone destruction. Porphyromonas gingivalis (Pg), one of the main periopathogens, initiates an inflammatory cascade by host immune cells thereby increasing recruitment and activity of osteoclasts, the bone resorbing cells, through enhanced production of the crucial osteoclastogenic factor, RANK-L. Antibodies directed against some cytokines (IL-1β, IL-6 and TNF-α) failed to exhibit convincing therapeutic effect in CP...
2016: PloS One
https://www.readbyqxmd.com/read/27978726/palladium-catalyzed-multicomponent-approach-to-%C3%AE-lactams-via-aryl-halide-carbonylation
#12
Gerardo M Torres, Maximiliano De La Higuera Macias, Jeffrey S Quesnel, Oliver P Williams, Veeranna Yempally, Ashfaq A Bengali, Bruce A Arndtsen
A palladium-catalyzed multicomponent method for the synthesis of β-lactams from imines, aryl halides, and CO has been developed. This transformation proceeds via two tandem catalytic carbonylation reactions mediated by Pd(P(t)Bu3)2 and provides a route to prepare these products from five separate reagents. A diverse range of polysubstituted β-lactams can be generated by systematic variation of the substrates. This methodology can also be extended to the use of iodo-substituted imines to produce novel spirocyclic β-lactams in good yields and selectivity...
December 16, 2016: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/27942560/dataset-for-analysing-the-relationships-among-economic-growth-fossil-fuel-and-non-fossil-fuel-consumption
#13
John Asafu-Adjaye, Dominic Byrne, Maximiliano Alvarez
The data presented in this article are related to the research article entitled 'Economic Growth, Fossil Fuel and Non-Fossil Consumption: A Pooled Mean Group Analysis using Proxies for Capital' (J. Asafu-Adjaye, D. Byrne, M. Alvarez, 2016) [1]. This article describes data modified from three publicly available data sources: the World Bank׳s World Development Indicators (http://databank.worldbank.org/data/reports.aspx?source=world-development-indicators), the U.S. Energy Information Administration׳s International Energy Statistics (http://www...
February 2017: Data in Brief
https://www.readbyqxmd.com/read/27931930/urban-dogs-in-rural-areas-human-mediated-movement-defines-dog-populations-in-southern-chile
#14
Federico J Villatoro, Maximiliano A Sepúlveda, Paulina Stowhas, Eduardo A Silva-Rodríguez
Management strategies for dog populations and their diseases include reproductive control, euthanasia and vaccination, among others. However, the effectiveness of these strategies can be severely affected by human-mediated dog movement. If immigration is important, then the location of origin of dogs imported by humans will be fundamental to define the spatial scales over which population management and research should apply. In this context, the main objective of our study was to determine the spatial extent of dog demographic processes in rural areas and the proportion of dogs that could be labeled as immigrants at multiple spatial scales...
December 1, 2016: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/27918440/a-computational-study-of-structure-and-reactivity-of-n-substitued-4-piperidones-curcumin-analogues-and-their-radical-anions
#15
Maximiliano Martínez-Cifuentes, Boris Weiss-López, Ramiro Araya-Maturana
In this work, a computational study of a series of N-substitued-4-piperidones curcumin analogues is presented. The molecular structure of the neutral molecules and their radical anions, as well as their reactivity, are investigated. N-substituents include methyl and benzyl groups, while substituents on the aromatic rings cover electron-donor and electron-acceptor groups. Substitutions at the nitrogen atom do not significantly affect the geometry and frontier molecular orbitals (FMO) energies of these molecules...
December 2, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27916580/annual-revision-rates-of-partial-versus-total-knee-arthroplasty-a-comparative-meta-analysis
#16
REVIEW
Harshvardhan Chawla, Jelle P van der List, Alexander B Christ, Maximiliano R Sobrero, Hendrik A Zuiderbaan, Andrew D Pearle
BACKGROUND: Utilization of unicompartmental knee arthroplasty (UKA) and patellofemoral arthroplasty (PFA) as alternatives to total knee arthroplasty (TKA) for unicompartmental knee osteoarthritis (OA) has increased. However, no single resource consolidates survivorship data between TKA and partial resurfacing options for each variant of unicompartmental OA. This meta-analysis compared survivorship between TKA and medial UKA (MUKA), lateral UKA (LUKA) and PFA using annual revision rate as a standardized metric...
December 1, 2016: Knee
https://www.readbyqxmd.com/read/27905650/-aseptic-techniques-for-minor-surgical-procedures
#17
Marcela Concha-Rogazy, Catalina Andrighetti-Ferrada, Maximiliano Curi-Tuma
Aseptic techniques are those practices designed to reduce the risk of surgical site infection (SSI), defined as such, all those that occur within the first 30 days of the procedure. While the patient’s risk of developing an SSI in dermatologic surgery is low since many of the procedures are considered sterile, there are different factors associated with an increased or decreased risk of developing SSI. The characteristics of the surgical wound (such as involving infected or inflamed tissue or when breaks in the aseptic technique occur), patient characteristics (such as age, comorbidities, medication use and smoking) and procedure factors (such as setting, surgical technique, type of procedure, duration and body region involved)...
August 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/27901250/perception-of-stroke-symptoms-and-utilization-of-emergency-medical-services
#18
Maximiliano A Hawkes, Mauricio F Farez, Ismael L Calandri, Sebastián F Ameriso
Methods: Review of hospital records and structured telephone interviews of 100 consecutive stroke patients. Forward stepwise logistic regression was used for the statistical analysis. Results: Seventy patients (75%) arrived at the hospital 4.5 hours after stroke symptoms onset. The use of EMS did not improve arrival times. Most patients who recognized their symptoms did not use EMS (p < 0.02). Nineteen patients (20%) were initially misdiagnosed. Eighteen of them were first assessed by non-neurologist physicians (p < 0...
November 2016: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/27891029/craniovertebral-junction-360%C3%A2-a-combined-microscopic-and-endoscopic-anatomical-study
#19
Sukhdeep Singh Jhawar, Maximiliano Nunez, Paolo Pacca, Daniel Seclen Voscoboinik, Huy Truong
OBJECTIVES: Craniovertebral junction (CVJ) can be approached from various corridors depending on the location and extent of disease. A three-dimensional understanding of anatomy of CVJ is paramount for safe surgery in this region. Aim of this cadaveric study is to elucidate combined microscopic and endoscopic anatomy of critical neurovascular structures in this area in relation to bony and muscular landmarks. MATERIALS AND METHODS: Eight fresh-frozen cadaveric heads injected with color silicon were used for this study...
October 2016: Journal of Craniovertebral Junction and Spine
https://www.readbyqxmd.com/read/27890669/doxorubicin-nanotechnological-overviews-from-bench-to-bedside
#20
REVIEW
Maximiliano Cagel, Estefanía Grotz, Ezequiel Bernabeu, Marcela A Moretton, Diego A Chiappetta
Doxorubicin (DOX) is considered one of the most effective chemotherapeutic agents, used as a first-line drug in numerous types of cancer. Nevertheless, it exhibits serious adverse effects, such as lethal cardiotoxicity and dose-limiting myelosuppression. In this review, we focus on the description and the clinical benefits of different DOX-loaded nanotechnological platforms, not only those commercially available but also the ones that are currently in clinical phases, such as liposomes, polymeric nanoparticles, polymer-drug conjugates, polymeric micelles and ligand-based DOX-loaded nanoformulations...
November 23, 2016: Drug Discovery Today
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