keyword
MENU ▼
Read by QxMD icon Read
search

Maximiliano

keyword
https://www.readbyqxmd.com/read/29326172/diversity-and-connectivity-of-layer-5-somatostatin-expressing-interneurons-in-the-mouse-barrel-cortex
#1
Nigro Maximiliano José, Yoshiko Hashikawa, Bernardo Rudy
Inhibitory interneurons represent 10-15% of the neurons in the somatosensory cortex, and their activity powerfully shapes sensory processing. Three major groups of GABAergic interneurons have been defined according to developmental, molecular, morphological, electrophysiological, and synaptic features. Dendritic-targeting somatostatin-expressing interneurons (SST-INs) have been shown to display diverse morphological, electrophysiological and molecular properties and activity patterns in vivo. However, the correlation between these properties and SST-IN subtype is unclear...
January 11, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29325545/phthiocerol-dimycocerosates-promote-access-to-the-cytosol-and-intracellular-burden-of-mycobacterium-tuberculosis-in-lymphatic-endothelial-cells
#2
Thomas R Lerner, Christophe J Queval, Antony Fearns, Urska Repnik, Gareth Griffiths, Maximiliano G Gutierrez
BACKGROUND: Phthiocerol dimycocerosates (PDIM), glycolipids found on the outer surface of virulent members of the Mycobacterium tuberculosis (Mtb) complex, are a major contributing factor to the pathogenesis of Mtb. Myelocytic cells, such as macrophages and dendritic cells, are the primary hosts for Mtb after infection and previous studies have shown multiple roles for PDIM in supporting Mtb in these cells. However, Mtb can infect other cell types. We previously showed that Mtb efficiently replicates in human lymphatic endothelial cells (hLECs) and that the hLEC cytosol acts as a reservoir for Mtb in humans...
January 4, 2018: BMC Biology
https://www.readbyqxmd.com/read/29320219/modified-latarjet-without-capsulolabral-repair-in-rugby-players-with-recurrent-anterior-glenohumeral-instability-and-significant-glenoid-bone-loss
#3
Maximiliano Ranalletta, Luciano A Rossi, Agustin Bertona, Ignacio Tanoira, Ignacio Alonso Hidalgo, Gastón D Maignon, Santiago L Bongiovanni
BACKGROUND: The optimal management of recurrent anterior shoulder instability with significant glenoid bone loss in high-demand collision athletes remains a challenge. PURPOSE: To analyze the time to return to sport, clinical outcomes, and recurrences following a modified Latarjet procedure without capsulolabral repair in rugby players with recurrent anterior shoulder instability and significant glenoid bone loss. STUDY DESIGN: Case series; Level of evidence, 4...
January 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29301877/draft-genome-sequences-of-enterohemorrhagic-and-enteropathogenic-escherichia-coli-strains-isolated-from-alpacas-in-peru
#4
Lenin Maturrano, Marjorie Aleman, Dennis Carhuaricra, Jorge Maximiliano, Juan Siuce, Luis Luna, Raul Rosadio
The draft genome sequences of two strains of Escherichia coli, isolated from alpacas in Peru, are reported here. ECA1 has been determined to be a strain of enterohemorrhagic E. coli and ECB1 a strain of enteropathogenic E. coli These pathogens are responsible for hemolytic-uremic syndrome in humans and diarrhea in different mammals, respectively.
January 4, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29277604/tolerance-to-hypometabolism-and-arousal-induced-by-hibernation-in-the-apple-snail-pomacea-canaliculata-caenogastropoda-ampullariidae
#5
Maximiliano Giraud-Billoud, Alfredo Castro-Vazquez, Alejandra D Campoy-Diaz, Pablo M Giuffrida, Israel A Vega
Pomacea canaliculata may serve as a model organism for comparative studies of oxidative damage and antioxidant defenses in active, hibernating and arousing snails. Oxidative damage (as TBARS), free radical scavenging capacity (as ABTS+ oxidation), uric acid (UA) and glutathione (GSH) concentrations, activities of superoxide dismutase (SOD) and catalase (CAT), and the protein expression levels of heat shock proteins (Hsp70, Hsc70, Hsp90) were studied in digestive gland, kidney and foot. Tissue TBARS of hibernating snails (45days) was higher than active snails...
December 19, 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/29276559/door-to-needle-time-in-acute-stroke-treatment-and-the-july-effect
#6
Maximiliano A Hawkes, Federico Carpani, Mauricio F Farez, Sebastian F Ameriso
Intravenous thrombolysis improves outcomes in acute ischemic stroke in a time-dependent fashion. As in teaching hospitals, clinical outcomes may worsen due to the arrival of new inexperienced house staff early in the academic year (July effect, JE), we evaluated the impact of the "JE" on the door-to-needle time for intravenous thrombolysis and other stroke outcomes. In this retrospective cohort study, we assessed all acute ischemic strokes treated with intravenous thrombolysis between July 2003 and June 2016...
January 2018: Neurohospitalist
https://www.readbyqxmd.com/read/29260478/interaction-of-pesticides-with-natural-and-synthetic-solids-evaluation-in-dynamic-and-equilibrium-conditions
#7
Julián Ortiz Otalvaro, Maximiliano Brigante
Interactions between pesticides (paraquat, glyphosate, 2,4-D, atrazine, and metsulfuron methyl) and soil organic and inorganic components have been studied in batch experiments by performing adsorption, dissolution, and chemical and photochemical degradation under different conditions. The obtained results confirm that the affinity of a pesticide to the solid surface depends on the nature of both and shows that each reactant strongly affects the mobility of the other one, e.g., anionic pesticides promote the dissolution of the solid humic acid but if this last is retained into the inorganic matrix enhances the adsorption of a cationic pesticide...
December 19, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29240047/synthesis-and-dft-calculations-of-novel-vanillin-chalcones-and-their-3-aryl-5-4-2-dimethylamino-ethoxy-3-methoxyphenyl-4-5-dihydro-1h-pyrazole-1-carbaldehyde-derivatives-as-antifungal-agents
#8
Luis Alberto Illicachi, Joel José Montalvo-Acosta, Alberto Insuasty, Jairo Quiroga, Rodrigo Abonia, Maximiliano Sortino, Susana Zacchino, Braulio Insuasty
Novel (E)-1-(aryl)-3-(4-(2-(dimethylamino)ethoxy)-3-methoxyphenyl) prop-2-en-1-ones 4 were synthesized by a Claisen-Schmidt reaction of 4-(2-(dimethylamino)ethoxy)-3-methoxy-benzaldehyde (2) with several acetophenone derivatives 3. Subsequently, cyclocondensation reactions of chalcones 4 with hydrazine hydrate afforded the new racemic 3-aryl-5-(4-(2-(dimethylamino)ethoxy)-3-methoxyphenyl)-4,5-dihydro-1H-pyrazole-1-carbaldehydes 5 when the reaction was carried out in formic acid. The antifungal activity of both series of compounds against eight fungal species was determined...
September 5, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29236882/narratives-of-family-members-on-the-suicide-of-older-adults-in-an-amazonian-metropolis
#9
André Luis Sales da Costa, Maximiliano Loiola Ponte de Souza
OBJECTIVE: To analyze the narratives of family members on the suicide of older adults in Manaus, State of Amazonas, Brazil. METHODS: This is a qualitative study of the narratives of eight older adults, who committed suicide in the period of 2001-2012. In the analytic-interpretative process, we have tried to perform the hermeneutic double exercise: to interpret the interpretation of narrators. We have used as theoretical references authors who have investigated suicide from the perspective of gender and its correlations with the sociofamiliar context and with mental disorders...
December 11, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29233751/differential-binding-of-antibodies-in-pandas-patients-to-cholinergic-interneurons-in-the-striatum
#10
Luciana Frick, Maximiliano Rapanelli, Kantiya Jindachomthong, Paul Grant, James F Leckman, Susan Swedo, Kyle Williams, Christopher Pittenger
Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcus, or PANDAS, is a syndrome of acute childhood onset of obsessive-compulsive disorder and other neuropsychiatric symptoms in the aftermath of an infection with Group A beta-hemolytic Streptococcus (GABHS). Its pathophysiology remains unclear. PANDAS has been proposed to result from cross-reactivity of antibodies raised against GABHS with brain antigens, but the targets of these antibodies are unclear and may be heterogeneous. We developed an in vivo assay in mice to characterize the cellular targets of antibodies in serum from individuals with PANDAS...
December 9, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29211151/characteristics-of-suicide-mortality-among-indigenous-and-non-indigenous-people-in-roraima-brazil-2009-2013
#11
Maximiliano Loiola Ponte de Souza, Ricardo Tadeu da Silva Onety
OBJECTIVE: to describe suicide characteristics and mortality rates among indigenous and non-indigenous people in Roraima, Brazil. METHODS: descriptive study using data from the Mortality Information System (SIM) about the suicides in individuals over 10 years old, recorded in the period from 2009 to 2013; suicide mortality rates were adjusted by sex and age. RESULTS: 170 suicide cases were reported, being 17.1% among indigenous people; median ages were 24 years among indigenous and 29 among non-indigenous people; four municipalities concentrated 25/29 of the suicides among indigenous people; the 141 suicides among non-indigenous people were distributed in 13/15 municipalities in the state; suicide mortality rates were 15...
October 2017: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://www.readbyqxmd.com/read/29205592/increase-of-prostaglandin-e2-in-the-reversal-of-ductal-constriction-after-polyphenol-restriction
#12
Izabele Vian, Paulo Zielinsky, Ana Maria Zílio, Maximiliano I Schaun, Camila Brum, Kenya Venusa Lampert, Nataly De Ávila, Giovana Baldissera, Tamires Mezzomo Klanovicz, Karina Zenki, Jesus Zurita-Peralta, Alessandro Olszewski, Antonio Piccoli, Luiz Henrique Nicoloso, Natássia Sulis, Luiza Van Der Sand, Melissa Markoski
OBJECTIVE: Anti-inflammatory substances that inhibit the synthesis of prostaglandins, such as nonsteroidal anti-inflammatory drugs (NSAIDs) and polyphenol-rich foods, can cause constriction of the fetal ductus arteriosus. This study aimed to test the hypothesis that reversal of fetal ductal constriction after maternal restriction of polyphenol-rich foods, in the third trimester of pregnancy, is accompanied by increased prostaglandin E2(PGE2) plasma levels. METHOD: A controlled clinical trial was designed...
December 5, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29187109/modified-in-situ-pericardial-rerouting-technique-for-scimitar-syndrome-repair
#13
Ignacio Lugones, María Fernanda Biancolini, Victoria Eugenia Zerpa Pacheco, Inés Ana Martínez, Jesús María Maximiliano Damsky Barbosa, Ana María Susana de Dios
Scimitar syndrome repair represents a challenge due to the high incidence of postoperative pulmonary venous obstruction associated with classic surgical strategies. In situ pericardial rerouting technique has been considered a promising alternative approach due to its simplicity and excellent midterm results. Access to the left atrium can be difficult in young patients with severe dextrocardia and hypoplastic right lung. We describe a modification of the original rerouting technique in which the atrial septum is repositioned in order to create a wide opening in the lateral aspect of the left atrium and ensure an adequate size of the reconstructed pathway...
November 2017: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/29180957/age-related-brain-activation-changes-during-rule-repetition-in-word-matching
#14
Ikram Methqal, Basile Pinsard, Mahnoush Amiri, Maximiliano A Wilson, Oury Monchi, Jean-Sebastien Provost, Yves Joanette
Objective: The purpose of this study was to explore the age-related brain activation changes during a word-matching semantic-category-based task, which required either repeating or changing a semantic rule to be applied. In order to do so, a word-semantic rule-based task was adapted from the Wisconsin Sorting Card Test, involving the repeated feedback-driven selection of given pairs of words based on semantic category-based criteria. Method: Forty healthy adults (20 younger and 20 older) performed a word-matching task while undergoing a fMRI scan in which they were required to pair a target word with another word from a group of three words...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29175392/genetic-ancestry-effects-on-the-distribution-of-toll-like-receptors-tlrs-gene-polymorphisms-in-a-population-of-the-atlantic-forest-s%C3%A3-o-paulo-brazil
#15
Lilian O Guimarães, Miklos Maximiliano Bajay, Eliana F Monteiro, Gerhard Wunderlich, Sidney E Santos, Karin Kirchgatter
The innate immune system governed by toll-like receptors (TLRs) provides the first line of defense against pathogens. Surface-localized TLR1 and TLR6 are known to detect parasite components. TLR encoding genes were shown to display signatures of recent positive selection in Europeans and might be involved in local adaptation at immune-related genes. To verify the influence of Brazilian population admixture on the distribution of polymorphisms in TLRs, we analyzed the genotype frequencies of 24 polymorphisms distributed across five TLR genes in a Southeastern Brazilian population where autochthonous cases of malaria occur in small foci of transmission...
November 23, 2017: Human Immunology
https://www.readbyqxmd.com/read/29174958/plant-phenolics-and-terpenoids-as-adjuvants-of-antibacterial-and-antifungal-drugs
#16
Susana A Zacchino, Estefania Butassi, Melina Di Liberto, Marcela Raimondi, Agustina Postigo, Maximiliano Sortino
BACKGROUND: The intensive use of antibacterial and antifungal drugs has dramatically increased the microbial resistance and has led to a higher number of difficult-to-eradicate infections. Combination therapy with two or more antimicrobial drugs has emerged some years ago to overcome the issue, but it has proven to be not completely effective. Natural secondary metabolites of MW ≤ 500 represent promising adjuvants for antimicrobials and have been the object of several researches that have increased in the last two decades...
December 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29166948/cause-specific-mortality-for-249-causes-in-brazil-and-states-during-1990-2015-a-systematic-analysis-for-the-global-burden-of-disease-study-2015
#17
Elisabeth B França, Valéria Maria de Azeredo Passos, Deborah Carvalho Malta, Bruce B Duncan, Antonio Luiz P Ribeiro, Mark D C Guimarães, Daisy M X Abreu, Ana Maria N Vasconcelos, Mariângela Carneiro, Renato Teixeira, Paulo Camargos, Ana Paula S Melo, Bernardo L Queiroz, Maria Inês Schmidt, Lenice Ishitani, Roberto Marini Ladeira, Otaliba L Morais-Neto, Maria Tereza Bustamante-Teixeira, Maximiliano R Guerra, Isabela Bensenor, Paulo Lotufo, Meghan Mooney, Mohsen Naghavi
BACKGROUND: Reliable data on cause of death (COD) are fundamental for planning and resource allocation priorities. We used GBD 2015 estimates to examine levels and trends for the leading causes of death in Brazil from 1990 to 2015. METHODS: We describe the main analytical approaches focused on both overall and specific causes of death for Brazil and Brazilian states. RESULTS: There was an overall improvement in life expectancy at birth from 1990 to 2015, but with important heterogeneity among states...
November 22, 2017: Population Health Metrics
https://www.readbyqxmd.com/read/29165746/computed-tomographic-localization-of-the-central-sulcus-a-morphometric-study-in-adult-patients
#18
Dan Zimelewicz Oberman, Jorge Rasmussen, Maximiliano Toscano, Ezequiel Goldschmidt, Pablo Ajler
AIM: Despite advances in intraoperative navigation and electrocorticography, neuroanatomical knowledge is an essential tool for neurosurgical planning. The aim of this study was to accurately describe the relations between the anatomical landmarks of the cranial convexity and the main cortical structures. MATERIAL AND METHODS: A retrospective cross-sectional, observational study was performed. Computed tomography scans of 71 adult patients with no pathological imaging were analyzed...
November 1, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/29162499/metabolic-strategies-for-the-degradation-of-the-neuromodulator-agmatine-in-mammals
#19
REVIEW
José Benítez, David García, Nicol Romero, Arlette González, José Martinez, Maximiliano Figueroa, Mónica Salas, Vasthi López, Peter R Dodd, Gerhard Schenk, Nelson Carvajal, Elena Uribe
Agmatine (1-amino-4-guanidinobutane), a precursor for polyamine biosynthesis, has been identified as an important neuromodulator with anticonvulsant, antineurotoxic and antidepressant actions in the brain. In this context it has emerged as an important mediator of addiction/satiety pathways associated with alcohol misuse. Consequently, the regulation of the activity of key enzymes in agmatine metabolism is an attractive strategy to combat alcoholism and related addiction disorders. Agmatine results from the decarboxylation of L-arginine in a reaction catalyzed by arginine decarboxylase (ADC), and can be converted to either guanidine butyraldehyde by diamine oxidase (DAO) or putrescine and urea by the enzyme agmatinase (AGM) or the more recently identified AGM-like protein (ALP)...
November 18, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29154960/porphyromonas-gingivalis-differentially-modulates-apoptosome-apaf-1-in-epithelial-cells-and-fibroblasts
#20
Isaac Maximiliano Bugueno, Fareeha Batool, Linda Korah, Nadia Benkirane-Jessel, Olivier Huck
Porphyromonas gingivalis is able to invade and modulate host-immune response to promote its survival. This bacterium modulates the cell cycle and programmed cell death, contributing to periodontal lesion worsening. Several molecular pathways have been identified as key triggers of apoptosis including apoptosome APAF-1. In this study, Apaf-1 and X-linked inhibitor of apoptosis protein (Xiap) mRNA were differentially expressed between gingival samples harvested from human healthy and chronic periodontitis tissues (Apaf-1: 19...
November 15, 2017: American Journal of Pathology
keyword
keyword
101047
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"