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Wei Liu, Xinshi Li, Wentao Li, Qiqi Zhang, Hua Bai, Junfang Li, Guangcheng Xi
Photothermal therapy (PTT) is one of promising cancer therapy with high efficiency and minimal invasiveness. Exploiting of perfect PTT agent is vital to improve the therapy. In this study, a new type of bow tie-like molybdenum dioxide (MoO 2 ) nanoparticles was successfully synthesized. These nanobow-ties had strong localized surface plasmon resonance (SPR) effect from visible to near infrared regions, and exhibited ultrahigh chemical stability. They could not only withstand high temperature heating without oxidation, but also resist the corrosion of strong acid and alkali...
February 8, 2018: Biomaterials
Seon Hoon Kim, Tae Un Kim, Haeng Yun Jung, Hyun Chul Ki, Doo Gun Kim, Byung-Teak Lee
The surface plasmon resonance (SPR) properties of Au/Ag bimetallic thin-film nanostructures were investigated to improve the chemical stability and the figure of merit (FOM) in the SPR sensors. The SPR characteristics such as resonance angle, extinction ratio, and full width half maximum (FWHM) were calculated by the simulation of the finite-difference time-domain method and were measured using the laser with a 632.8 nm wavelength in the Kretschmann-Raether configuration. The measured resonance angle, extinction ratio, FWHM of Au(20 nm)/Ag(20 nm) thin-film nanostructure were found to be 44°, 0...
March 1, 2018: Journal of Nanoscience and Nanotechnology
Ji-Young Ahn, Kyeong-Ah Lee, Moon-Jong Lee, Simranjeet Singh Sekhon, Sung-Keun Rhee, Sung-Jin Cho, Jung Ho Ko, Lyon Lee, Janet Han, Sang Yong Kim, Jiho Min, Yang-Hoon Kim
In this paper, whole-bacteria SELEX (WB-SELEX) strategy was adopted to isolate specific aptamers against Vibrio parahaemolyticus. Round selection for V. parahaemolyticus was conducted 11 rounds, including two negative selection rounds. It was determined through real-time PCR amplification and post-SELEX experiment. The selected aptmers had high binding property and specificity to V. parahaemolyticus. Of 28 aptamers tested, VPCA-apta#1 had the highest binding affinity compared to other aptamer candidates obtained...
March 1, 2018: Journal of Nanoscience and Nanotechnology
Ting Wu, Qinghong Kong, Hongkai Zhang, Junhao Zhang
NiAl layered double hydroxide (NiAl-LDH) was synthesized by co-precipitation method. And sodium dodecyl sulphate (SDS) as modifier was utilized to enlarge the d-spacing of NiAl-LDH to obtain SDS-NiAl-LDH. PP/SDS-NiAl-LDH nanocomposites were prepared with different amount of SDS- NiAl-LDH and PP by melt intercalation method. The results of XRD and TEM confirmed that intercalated and exfoliated-intercalated structures were formed. Compared with pure PP, PP/SDS- NiAl-LDH nanocomposites exhibited high thermal stability and residual to the presence of barrier effect of NiAl-LDH layers...
February 1, 2018: Journal of Nanoscience and Nanotechnology
Shan Sun, Mingzhu He, Yongjun Wang, Huan Yang, Yousef Al-Abed
High mobility group box 1 (HMGB1) is a damage-associated molecular pattern (DAMP) protein that mediates inflammatory responses after infection or injury. Previously, we reported a peptide inhibitor of HMGB1 (P5779) that acts by directly interrupting HMGB1/MD-2 binding. Here, fingerprint similarity search and docking studies suggest folic acid derived-drugs function as P5779 mimetopes. Molecular dynamic (MD) simulation studies demonstrate that folic acid mimics the binding of P5779 at the TLR4 and MD-2 intersection...
2018: PloS One
Gajendra Kumar Inwati, Yashvant Rao, Man Singh
The Cu nanoparticles (Cu NPs) were grown in soda-lime glass matrix through Cu + ↔ Na + ion exchange methods under thermal annealing in an open environment and studied variation in their size on tunable plasmonic behaviour, optical absorption spectra and photoluminescence (PL). A blue shift from 570 to 560 nm was observed in localized surface plasmon resonance (SPR) of Cu NPs from 550 to 650 °C. A mutual relation between size and surface plasmon resonance with full width half maxima (FWHM) has been derived for plasmonic properties at variable temperatures...
February 14, 2018: Scientific Reports
Andrea R Yung, Noah R Druckenbrod, Jean-François Cloutier, Zhuhao Wu, Marc Tessier-Lavigne, Lisa V Goodrich
During brainstem development, newborn neurons originating from the rhombic lip embark on exceptionally long migrations to generate nuclei important for audition, movement, and respiration. Along the way, this highly motile population passes several cranial nerves yet remains confined to the CNS. We found that Ntn1 accumulates beneath the pial surface separating the CNS from the PNS, with gaps at nerve entry sites. In mice null for Ntn1 or its receptor DCC, hindbrain neurons enter cranial nerves and migrate into the periphery...
February 13, 2018: Cell Reports
Myeong-Sub Song, Simranjeet Singh Sekhon, Woo-Ri Shin, Sung-Keun Rhee, Jung Ho Ko, Sang Yong Kim, Jiho Min, Ji-Young Ahn, Yang-Hoon Kim
Shigella sonnei isolate invasion plasmid antigen protein, IpaH, was successfully expressed in recombinant overexpression bacterial system. The soluble expression IpaH was enhanced with molecular chaperon co-expressed environment. Specific aptamer IpaH17 was isolated through the SELEX process and showed fM binding affinity. IpaH17-SPR biosensor platform was involved to verify the binding sensitivity and specificity. The IpaH concentration dependent IpaH17-SPR sensor response was highly linear with a linear regression constant of 99...
May 1, 2018: Journal of Nanoscience and Nanotechnology
Shuai Zhang, Shi-Lin Zhou, Jun-Jun Liu, De-Jun Yang, Jing-Jing Xue, Chang-Tang Chang
T-Ag/ZnO nanoflowers were successfully fabricated via two steps methods on zinc foil. The chemical composition of norfloxacin was investigated by FTIR spectroscopy. The morphology, composition, and structural and optical properties of the as-synthesized materials were characterized. The results show that triangular silver nanoplates exhibit unique surface plasmon resonance (SPR) absorption spectra, and the absorption spectrum range of ZnO nanoflowers are effectively expanded by coating triangular silver nanoplates...
June 1, 2018: Journal of Nanoscience and Nanotechnology
Qinghong Kong, Ting Wu, Hong Liu, Yi Zhang, Manman Zhang, Yibing Cai, Junhao Zhang, Ling Yang
Many current flame retardant technologies for polymeric materials contain environmentally harmful compounds, negatively impact processing and mechanical properties. In an effort to tackle these issues, graphene oxide (GO) nanocoating was deposited on the surface of polyurethane sponge (PUS) to reduce its flammability via layer-by-layer (LbL) assembly method. The results indicated that GO was evenly distributed on the surface of PUS to form GO coating PUS (PUS@GO) composites. This coating system completely eliminated melt dripping of sponge upon exposure to the direct flame from a butane torch...
July 1, 2018: Journal of Nanoscience and Nanotechnology
Susan J Back, Carolina Maya, Kassa Darge, Patricia T Acharya, Carol E Barnewolt, Jamie L Coleman, Jonathan R Dillman, Lynn Ansley Fordham, Misun Hwang, Annie Lim, M Beth McCarville, Marthe M Munden, Harriet J Paltiel, Frank M Volberg
BACKGROUND: The United States Food and Drug Administration (FDA) recently approved an ultrasound (US) contrast agent for intravenous and intravesical administration in children. OBJECTIVE: Survey the usage, interest in and barriers for contrast-enhanced US among pediatric radiologists. MATERIALS AND METHODS: The Contrast-Enhanced Ultrasound Task Force of the Society for Pediatric Radiology (SPR) surveyed the membership of the SPR in January 2017 regarding their current use and opinions about contrast-enhanced US in pediatrics...
February 13, 2018: Pediatric Radiology
Chen Yang, Ying Chen, Dan Liu, Cheng Chen, Jiemin Wang, Ye Fan, Shaoming Huang, Weiwei Lei
The development of ideal three-dimensional (3D) tailorable surface-enhanced Raman scattering (SERS) substrates with the properties of timesaving, large area, high-throughput, single or few molecules detection, reproducibility, reusable ability and high density of "hot spots", has been the mainstream challenge and robust task. Here, we construct perpendicularly sandwich-like Au@Al2O3@Au hybrid nanosheets (PSHNs) on the Al foil as a 3D flexible substrate for SERS. The design of 3D PSHNs incorporates several advantageous aspects for SERS to enhance the performance of plasmonic diamers via bi-functions of vertical Al2O3 nanosheets (NSs) including the nano-scaffold and nano-baffle plate effects...
February 14, 2018: ACS Applied Materials & Interfaces
Naoko Obi, Tetsuya Fukuda, Noboru Nakayama, John Ervin, Yasuhiko Bando, Toshihide Nishimura, Satoru Nagatoishi, Kouhei Tsumoto, Takeshi Kawamura
RATIONALE: Drug discovery studies invariably require qualitative and quantitative analyses of target compounds at every stage of drug discovery. We have developed a system combining molecular interaction analysis and mass spectrometry (LC-MS) using the principle of nano pore optical interferometry (nPOI) called molecular interaction kinetics-mass spectrometry (MIK-MS). Since nPOI has high binding capacity, the bond-dissociated compound can be directly detected using LC-MS. In this study, we use carbonic anhydrase (CA) II as a ligand and apply six small compounds as analytes and report the affinity analysis using MIK-MS...
February 14, 2018: Rapid Communications in Mass Spectrometry: RCM
Pradipta Ranjan Rauta, Pavan M Hallur, Aditya Chaubey
Identification and isolation of low-frequency cells of interest from a heterogeneous cell mixture is an important aspect of many diagnostic applications (including enumeration of circulating tumor cells) and is integral to various assays in (cancer) biology. Current techniques typically require expensive instrumentation and are not amenable to high throughput. Here, we demonstrate a simple and effective platform for cell detection and isolation using gold nanoparticles (Au NPs) conjugated with hyaluronic acid (HA) i...
February 13, 2018: Scientific Reports
D Max Crowley, Kenneth A Dodge, W Steven Barnett, Phaedra Corso, Sarah Duffy, Phillip Graham, Mark Greenberg, Ron Haskins, Laura Hill, Damon E Jones, Lynn A Karoly, Margaret R Kuklinski, Robert Plotnick
Over a decade ago, the Society for Prevention Research endorsed the first standards of evidence for research in preventive interventions. The growing recognition of the need to use limited resources to make sound investments in prevention led the Board of Directors to charge a new task force to set standards for research in analysis of the economic impact of preventive interventions. This article reports the findings of this group's deliberations, proposes standards for economic analyses, and identifies opportunities for future prevention science...
February 12, 2018: Prevention Science: the Official Journal of the Society for Prevention Research
Md Azahar Ali, Shawana Tabassum, Qiugu Wang, Yifei Wang, Ratnesh Kumar, Liang Dong
This paper reports an integrated dual-modality microfluidic sensor chip, consisting of a patterned periodic array of nanoposts coated with gold (Au) and graphene oxide (GO), to detect target biomarker molecules in a limited sample volume. The device generates both electrochemical and surface plasmon resonance (SPR) signals from a single sensing area of Au-GO nanoposts. The Au-GO nanoposts are functionalized with specific receptor molecules, serving as a spatially well-defined nanostructured working electrode for electrochemical sensing, as well as a nanostructured plasmonic crystal for SPR-based sensing via the excitation of surface plasmon polaritons...
February 12, 2018: Lab on a Chip
Liu Huang, Xiaodong Wan, Hongpan Rong, Yuan Yao, Meng Xu, Jia Liu, Muwei Ji, Jiajia Liu, Lan Jiang, Jiatao Zhang
High-efficient charge and energy transfer between nanocrystals (NCs) in a bottom-up assembly are hard to achieve, resulting in an obstacle in application. Instead of the ligands exchange strategies, the advantage of a continuous laser is taken with optimal wavelength and power to irradiate the film-scale NCs superlattices at solid-liquid interfaces. Owing to the Au-based NCs' surface plasmon resonance (SPR) effect, the gentle laser irradiation leads the Au NCs or Au@CdS core/shell NCs to attach each other with controlled pattern at the interfaces between solid NCs phase and liquid ethanol/ethylene glycol...
February 12, 2018: Small
Ki Wook Yun, Hoan Jong Lee, Ji Young Park, Hye-Kyung Cho, Yae-Jean Kim, Kyung-Hyo Kim, Nam Hee Kim, Young Jin Hong, Dong Ho Kim, Hwang Min Kim, Sung-Ho Cha
BACKGROUND: This study was performed with the aim of determining the long-term immunogenicity of an inactivated, Vero cell culture-derived Japanese encephalitis (JE) vaccine (JE-VC) and an inactivated, mouse brain-derived JE vaccine (JE-MB) after the 1st booster dose at 2 years of age, as well as the safety and immunogenicity of the 2nd booster dose of JE-VC at 6 years of age, in children primed and given a 1st booster dose of either JE-VC or JE-MB. METHOD: In this multicenter, open-label clinical trial, the study population consisted of healthy Korean children (aged 6 years) who participated in the previous JE vaccine trial...
February 8, 2018: Vaccine
Baishnisha Amanulla, Hema Kalyani Rama Subbu, Sayee Kannan Ramaraj
This paper describes a simple, selective and sensitive colorimetric sensing of Cr6+ ions using β-Cyclodextrin (β-CD) functionalized gold-iron nanoparticles (β-CD/Au-FeNPs). The sonochemically synthesized nanoparticles are winered in colour due to the SPR band of β-CD functionalized bimetalic nanoparticles Au-FeNPs. The capping and stabilizing of Au-FeNPs by redox β-CD is confirmed by FT-IR. The particles are spherical in shape and it posses the effective diameter of 18-20 nm. Under optimized conditions, in the presence of Cr6+ the wine red Au-FeNPs solution was turned to colourless, accompanying the broadening and red shifting of SPR band...
April 2018: Ultrasonics Sonochemistry
Laurent Cattiaux, Vanessa Porkolab, Franck Fieschi, Jean-Maurice Mallet
A branched amino acid was synthesized from methyl glucopyranoside; this amino acid presents three amino groups protected by Fmoc and one acid group and can be used in classic peptide synthesis. In parallel, similar azido terminated blocks were synthesized. Successive coupling reaction and deprotection afforded dendrimers with up to 27 azido functional groups. As an example of application, d-mannose and l-fucose residues were linked through CuAAC coupling and resulting glycodendrimers were evaluated in their interaction with DC-SIGN using SPR competition assay...
December 26, 2017: Bioorganic & Medicinal Chemistry
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