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https://www.readbyqxmd.com/read/28723204/crossed-surface-relief-gratings-as-nanoplasmonic-biosensors
#1
Srijit Nair, Carlos Escobedo, Ribal Georges Sabat
We present an original, low-cost nanoplasmonic (bio)sensor based on crossed surface relief gratings (CSRGs) generated from orthogonally superimposed surface relief gratings (SRGs) on gold-coated azo-glass substrate. This surface plasmon resonance (SPR)-based sensing approach is unique, since the light transmitted through a CSRG is zero except in the narrow bandwidth where the SPR conversion occurs, enabling quantitative monitoring of only the plasmonic signal from biomolecular interactions in real time. We validated the individual SRG plasmonic signature of CSRGs by observing their respective SPR excitation peaks, and tested them to detect both bulk and near-surface refractive index (RI) changes...
March 24, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28723093/plasmonic-aerogels-as-a-3d-nanoscale-platform-for-solar-fuels-photocatalysis
#2
Paul A DeSario, Jeremy J Pietron, Adam Dunkelberger, Todd H Brintlinger, Olga Baturina, Rhonda M Stroud, Jeffrey C Owrutsky, Debra R Rolison
We use plasmonic Au-TiO2 aerogels as a platform in which to marry synthetically thickened particle-particle junctions in TiO2 aerogel networks and Au||TiO2 interfaces and then investigate their cooperative influence on photocatalytic hydrogen (H2) generation under both broadband (i.e., UV + visible light) and visible-only excitation. In doing so, we elucidate the dual functions that incorporated Au can play as a water reduction/H2 generation co-catalyst and as a plasmonic sensitizer. We also introduce non-plasmonic Pt co-catalyst nanoparticles into our composite aerogels in order to leverage the catalytic water-reducing abilities of Pt...
July 19, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28723090/transformative-heterointerface-evolution-and-plasmonic-tuning-of-anisotropic-trimetallic-nanoparticles
#3
Mouhong Lin, Gyeong-Hwan Kim, Jae-Ho Kim, Jeong-Wook Oh, Jwa-Min Nam
Multi-component nanoparticles that incorporate multiple nano-crystal domains into a single particle represent an important class of material with highly tailorable structures and properties. The controlled synthesis of multi-component NPs with 3 or more components with the desired structure, particularly aniso-tropic structures, and property is, however, highly challenging. Here, we developed a polymer and galvanic replacement reac-tion-based transformative heterointerface evolution (THE) method to form and tune gold-copper-silver multi-metallic ani-sotropic nanoparticles (MAPs) with well-defined configurations, including structural order, uniformity and junction geometry, giving rise to extraordinarily high tunability in the structural design, synthesis and optical property of tri-metallic plasmonic nanoantenna structures...
July 19, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28722437/surface-plasmon-resonance-clinical-biosensors-for-medical-diagnostics
#4
Jean-Francois Masson
The design and application of sensors for monitoring biomolecules in clinical samples is a common goal of the sensing research community. Surface plasmon resonance (SPR) and other plasmonic techniques such as localized surface plasmon resonance (LSPR) and imaging SPR are reaching a maturity level sufficient for their application in monitoring biomolecules in clinical samples. In recent years, the first examples for monitoring antibodies, proteins, enzymes, drugs, small molecules, peptides, and nucleic acids in biofluids collected from patients afflicted with a series of medical conditions (Alzheimer's, hepatitis, diabetes, leukemia, and cancers such as prostate and breast cancers, among others) demonstrate the progress of SPR sensing in clinical chemistry...
January 27, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28722428/bsa-sugar-conjugates-as-ideal-building-blocks-for-spr-based-glycan-biosensors
#5
Shun Tao, Tian-Wei Jia, Yang Yang, Li-Qiang Chu
Controlled immobilization of sugar probes is of key importance for the development of glycan biosensors. To this end, a series of BSA-sugar conjugates with different numbers of mannose units are prepared via the squaric acid-mediated coupling reaction. The conjugates can absorb directly on gold substrate without any derivation reactions, thus providing a simple and effective method for the construction of SPR-based glycan biosensors. SPR measurements show that the BSA-mannose conjugate with 11 mannoses exhibit the highest affinity to the lectin concanavalin A with a limit of detection of ca...
January 27, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28715697/development-of-simultaneous-nitrification-denitrification-snd-in-biofilm-reactors-with-partially-coupled-a-novel-biodegradable-carrier-for-nitrogen-rich-water-purification
#6
Jing Zhao, Lijuan Feng, Guangfeng Yang, Jincheng Dai, Jun Mu
Development of simultaneous nitrification-denitrification (SND) is a promising approach for nitrogen-rich water purification. Coupling biofilm reactors with novel biodegradable carrier of Pumelo Peel (PP) and various conventional plastic fillers (polyurethane filler, SPR-1 suspension filler, TA-II elastic filler and sphere filler) were examined to achieve SND in this study. Results represented that partially coupled with PP could achieve highly efficient SND. Optimal performance appealed in a bioreactor of coupling PP and SPR-1filler with ammonia and total nitrogen removal efficiencies of 96...
June 26, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28714663/harnessing-hot-electrons-from-near-ir-light-for-hydrogen-production-using-pt-end-capped-aunrs
#7
Nathalia Ortiz, Brandon Zoellner, Soung Joung Hong, Yue Ji, Tao Wang, Yang Liu, Paul A Maggard, Gufeng Wang
Gold nanorods show great potential in harvesting natural sun light and generating hot charge carriers that can be employed to produce electrical or chemical energies. We show that photochemical reduction of Pt(IV) to Pt metal mainly takes place at the ends of gold nanorods (AuNRs), suggesting photon-induced hot electrons are localized in a time-averaged manner at AuNR ends. To use these hot electrons efficiently, a novel synthetic method to selectively overgrow Pt at the ends of AuNRs has been developed. These Pt-end-capped AuNRs show relatively high activity for the production of hydrogen gas using artificial white light, natural sun light, and more importantly, near IR light at 976 nm...
July 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28710920/thermodynamics-and-kinetics-of-rna-tertiary-structure-formation-in-the-junctionless-hairpin-ribozyme
#8
Neil A White, Charles G Hoogstraten
The hairpin ribozyme consists of two RNA internal loops that interact to form the catalytically active structure. This docking transition is a rare example of intermolecular formation of RNA tertiary structure without coupling to helix annealing. We have used temperature-dependent surface plasmon resonance (SPR) to characterize the thermodynamics and kinetics of RNA tertiary structure formation for the junctionless form of the ribozyme, in which loops A and B reside on separate molecules. We find docking to be strongly enthalpy-driven and to be accompanied by substantial activation barriers for association and dissociation, consistent with the structural reorganization of both internal loops upon complex formation...
July 8, 2017: Biophysical Chemistry
https://www.readbyqxmd.com/read/28710312/aspirin-inhibits-cancer-metastasis-and-angiogenesis-via-targeting-heparanase
#9
Xiao-Yang Dai, Juan Yan, Xuhong Fu, Qiuming Pan, Danni Sun, Yuan Xu, Jiang Wang, Litong Nie, Lin-Jiang Tong, Aijun Shen, Mingyue Zheng, Min Huang, Minjia Tan, Hong Liu, Xun Huang, Jian Ding, Meiyu Geng
<br />Recent epidemiological and clinical studies have suggested the benefit of aspirin for cancer patients, which inspired increasing efforts to demonstrate the anti-cancer ability of aspirin and reveal the molecular mechanisms behind. Nevertheless, the anti-cancer activity and related mechanisms of aspirin remain largely unknown. This study aimed to confirm this observation, and more importantly, to investigate the potential target contributed to the anti-cancer of aspirin.<br /><br />Experimental Design:<br /><span style="font-size: 11px;">A homogeneous time resolved fluorescence (HTRF) assay was used to examine the impact of aspirin on heparanase...
July 14, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28709976/glutathione-peroxidase-4-catalyzed-reduction-of-lipid-hydroperoxides-in-membranes-the-polar-head-of-membrane-phospholipids-binds-the-enzyme-and-addresses-the-fatty-acid-hydroperoxide-group-toward-the-redox-center
#10
Giorgio Cozza, Monica Rossetto, Valentina Bosello-Travain, Matilde Maiorino, Antonella Roveri, Stefano Toppo, Mattia Zaccarin, Lucio Zennaro, Fulvio Ursini
GPx4 is a monomeric glutathione peroxidase, unique in reducing the hydroperoxide group (-OOH) of fatty acids esterified in membrane phospholipids. This reaction inhibits lipid peroxidation and accounts for enzyme's vital role. Here we investigated the interaction of GPx4 with membrane phospholipids. A cationic surface near the GPx4 catalytic center interacts with phospholipid polar heads. Accordingly, SPR analysis indicates cardiolipin as the phospholipid with maximal affinity to GPx4. Consistent with the electrostatic nature of the interaction, KCl increases the KD...
July 12, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28709376/the-enhanced-photo-electrochemical-detection-of-uric-acid-on-au-nanoparticles-modified-glassy-carbon-electrode
#11
Yuting Shi, Jin Wang, Shumin Li, Bo Yan, Hui Xu, Ke Zhang, Yukou Du
In this work, a sensitive and novel method for determining uric acid (UA) has been developed, in which the glassy carbon electrode (GCE) was modified with electrodeposition Au nanoparticles and used to monitor the concentration of UA with the assistant of visible light illumination. The morphology of the Au nanoparticles deposited on GCE surface were characterized by scanning electron microscope (SEM) and the nanoparticles were found to be well-dispersed spheres with the average diameter approaching 26.1 nm...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28707664/-a-study-of-recombinant-human-sestrin-1-and-sestrin-2-proteins-produced-in-a-prokaryotic-system
#12
N Rai, R Kumar, Md A Haque, Md I Hassan, S Dey
Sestrins are highly conserved stress-inducible proteins capable of suppressing the production of ROS and signalling through mTORC1. Here we report a study of human sestrin1 (sesn1) and sestrin2 (sesn2) proteins produced in a pET28^(+) vector based prokaryotic system. Mass spectrometry analysis, western blot and surface plasmon resonance (SPR) of affinity purified sesn1 and sesn2 proteins confirmed their identity; biophysical characteristics were observed using circular dichroism (CD) showing that sesn1 and sesn2 have a predominant α-helical structure...
May 2017: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/28704805/biothiols-induced-colour-change-of-silver-nanoparticles-a-colorimetric-sensing-strategy
#13
Ambily Thomas, Unni Sivasankaran, Krishnapillai Girish Kumar
A sensor for the detection and determination of bio-thiols (glutathione (GSH) and cysteamine (Cyste)) has been developed by integrating the distinguished distance related optical characteristics of silver nanoparticles with the simplicity of colorimetric technique. In presence of these analytes, shift in surface plasmon resonance (SPR) absorption of silver nanoparticles (AgNPs) with change in its colour was observed. Yellow coloured AgNPs solution becomes colourless in presence of GSH and changes to red in presence of Cyste...
July 2, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28704417/bayesian-spatio-temporal-modeling-of-mortality-in-relation-to-malaria-incidence-in-western-kenya
#14
Sammy Khagayi, Nyaguara Amek, Godfrey Bigogo, Frank Odhiambo, Penelope Vounatsou
INTRODUCTION: The effect of malaria exposure on mortality using health facility incidence data as a measure of transmission has not been well investigated. Health and demographic surveillance systems (HDSS) routinely capture data on mortality, interventions and other household related indicators, offering a unique platform for estimating and monitoring the incidence-mortality relationship in space and time. METHODS: Mortality data from the HDSS located in Western Kenya collected from 2007 to 2012 and linked to health facility incidence data were analysed using Bayesian spatio-temporal survival models to investigate the relation between mortality (all-cause/malaria-specific) and malaria incidence across all age groups...
2017: PloS One
https://www.readbyqxmd.com/read/28704040/uniaxially-stretched-flexible-surface-plasmon-resonance-film-for-versatile-surface-enhanced-raman-scattering-diagnostics
#15
Kaichen Xu, Zuyong Wang, Chuan Fu Tan, Ning Kang, Lianwei Chen, Lei Ren, Eng San Thian, Ghim Wei Ho, Rong Ji, Minghui Hong
Surface enhanced Raman scattering (SERS) spectroscopy affords a rapid, highly sensitive and non-destructive approach for label-free and finger-print diagnosis of a wide range of chemicals. It is of great significance to develop large-area, uniform and environmentally friendly SERS substrates for in-situ identification of analytes on complex topological surfaces. In this work, we demonstrate a biodegradable flexible SERS film via irreversibly and longitudinally stretching metal deposited biocompatible poly (ɛ-caprolactone) film...
July 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28686257/an-alkylating-immobilization-linker-for-immunochemical-epigenetic-assessment
#16
Takaaki Kurinomaru, Naoshi Kojima, Ryoji Kurita
A bifunctional linker molecule containing nitrogen mustard and a cyclic disulfide group has been developed for the covalent immobilization of intact DNA, which allows quantitative analysis of epigenomic modification in immobilized DNA using SPR-based immune sensing.
July 7, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28684999/mechanism-of-action-of-selective-inhibitors-of-il-6-induced-stat3-pathway-in-head-and-neck-cancer-cell-lines
#17
Malabika Sen, Paul A Johnston, Netanya I Pollock, Kara DeGrave, Sonali C Joyce, Maria L Freilino, Yun Hua, Daniel P Camarco, David A Close, Donna M Huryn, Peter Wipf, Jennifer R Grandis
Studies indicate that elevated interleukin-6 (IL-6) levels engage IL6Rα-gp130 receptor complexes to activate signal transducer and activator of transcription 3 (STAT3) that is hyperactivated in many cancers including head and neck squamous cell carcinoma (HNSCC). Our previous HCS campaign identified several hits that selectively blocked IL-6-induced STAT3 activation. This study describes our investigation of the mechanism(s) of action of three of the four chemical series that progressed to lead activities: a triazolothiadiazine (864669), amino alcohol (856350), and an oxazole-piperazine (4248543)...
July 2017: Journal of Chemical Biology
https://www.readbyqxmd.com/read/28682637/synthesis-and-immunological-studies-of-the-lipomannan-backbone-glycans-found-on-the-surface-of-mycobacterium-tuberculosis
#18
Harin Leelayuwapan, Niwat Kangwanrangsan, Runglawan Chawengkirttikul, Marisa Ponpuak, Ratthaphol Charlermroj, Kanokthip Boonyarattanakalin, Somsak Ruchirawat, Siwarutt Boonyarattanakalin
Investigations into novel bacterial drug targets and vaccines are necessary to overcome tuberculosis. Lipomannan (LM), found on the surface of Mycobacterium tuberculosis (Mtb), is actively involved in the pathogenesis and survival of Mtb. Here, we report for the first time a rapid synthesis and biological activities of an LM glycan backbone, α(1-6)mannans. The rapid synthesis is achieved via a regio- and stereoselective ring opening polymerization to generate multiple glycosidic bonds in one simple chemical step, allowing us to finish assembling the defined polysaccharides of 5-20 units within days rather than years...
July 6, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28682593/selective-and-high-dynamic-range-assay-format-for-multiplex-detection-of-pathogenic-pseudomonas-aeruginosa-salmonella-typhimurium-and-legionella-pneumophila-rnas-using-surface-plasmon-resonance-imaging
#19
F Melaine, M Saad, S Faucher, M Tabrizian
Due to its well-characterized and highly conserved structure, as well as its relative abundance in metabolically active cells, bacterial 16S rRNA sequence plays an important role in microbial identification. In this work, a biosensing strategy has been developed for simultaneous detection of 16S rRNA analytes of three pathogenic bacterial strains: Legionella pneumophila, Pseudomonas aeruginosa, and Salmonella typhimurium. Surface plasmon resonance imaging (SPRi) was used as a detection technique coupled with DNA probe sandwich assemblies and gold nanoparticles (GNPs) for signal amplification...
July 6, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28678019/comprehensive-analysis-of-proton-range-uncertainties-related-to-stopping-power-ratio-estimation-using-dual-energy-ct-imaging
#20
Bin Li, Heui Chang Lee, Xinhui Duan, Chenyang Shen, Linghong Zhou, Xun Jia, Ming Yang
The dual-energy CT-based (DECT) approach holds promise in reducing the overall uncertainty in proton stopping-power-ratio (SPR) estimation as compared to the conventional stoichiometric calibration approach. The objective of this study was to analyze the factors contributing to uncertainty in SPR estimation using the DECT-based approach and to derive a comprehensive estimate of the range uncertainty associated with SPR estimation in treatment planning. Two state-of-the-art DECT-based methods, the Hünemohr-Saito method (2014, 2012) and the Bourque method (2014), were selected and implemented on a Siemens SOMATOM Force DECT scanner...
July 5, 2017: Physics in Medicine and Biology
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