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Shujahadeen B Aziz
In this work, copper (Cu) nanoparticles with observable surface plasmonic resonance (SPR) peaks were synthesized by an in-situ method. Chitosan host polymer was used as a reduction medium and a capping agent for the Cu nanoparticles. The surface morphology of the samples was investigated through the use of scanning electron micrograph (SEM) technique. Copper nanoparticles appeared as chains and white specks in the SEM images. The strong peaks due to the Cu element observed in the spectrum of energy dispersive analysis of X-rays...
December 13, 2017: Nanomaterials
F F Qin, C X Xu, Q X Zhu, J F Lu, D T You, W Xu, Z Zhu, A G Manohari, F Chen
We observed the dramatic enhancement of the intrinsic spontaneous and stimulated emission as well as the ensuing suppression of defect-related green emission in Au-decorated ZnO microrods. A series of spectral experiments and theoretical analysis demonstrated an electron transfer assisted process by surface plasmon (SP) resonant coupling between the Au nanoparticles and ZnO. The mechanism indicates an approach to enhance the UV emission of ZnO through an extra excitation of visible light similar to that for the defect emission of ZnO...
December 13, 2017: Nanoscale
Marta Sanmartí-Espinal, Patrizia Iavicoli, Annalisa Calò, Marta Taulés, Roger Galve, M Pilar Marco, Josep Samitier
This study aims to improve our understanding of the interaction between olfactory receptors and odorants to develop highly selective biosensing devices. Natural nanovesicles (NVs) from Saccharomyces cerevisiae, ~100 nm in diameter, carrying either the human OR17-40 or the chimpanzee OR7D4 olfactory receptor (OR) tagged with the c-myc epitope at their N-terminus, are presented as model systems to quantify the interaction between odorant and olfactory receptors. The level of expression of olfactory receptors was determined at individual NVs using a novel competitive ELISA immunoassay comparing the values obtained against those from techniques involving the solubilization of cell membrane proteins and the identification of c-myc-carrying receptors...
December 13, 2017: Scientific Reports
Flavia Anna Mercurio, Concetta Di Natale, Luciano Pirone, Roberta Iannitti, Daniela Marasco, Emilia Maria Pedone, Rosanna Palumbo, Marilisa Leone
The lipid phosphatase Ship2 represents a drug discovery target for the treatment of different diseases, including cancer. Its C-terminal sterile alpha motif domain (Ship2-Sam) associates with the Sam domain from the EphA2 receptor (EphA2-Sam). This interaction is expected to mainly induce pro-oncogenic effects in cells therefore, inhibition of the Ship2-Sam/EphA2-Sam complex may represent an innovative route to discover anti-cancer therapeutics. In the present work, we designed and analyzed several peptide sequences encompassing the interaction interface of EphA2-Sam for Ship2-Sam...
December 12, 2017: Scientific Reports
Yinan Zou, Yan Li, Jo-Anne R Dillon
BACKGROUND: Bacterial cell division is an essential process driven by the formation of a Z-ring structure, as a cytoskeletal scaffold at the mid-cell, followed by the recruitment of various proteins which form the divisome. The cell division interactome reflects the complement of different interactions between all divisome proteins. To date, only two cell division interactomes have been characterized, in Escherichia coli and in Streptococcus pneumoniae. The cell divison proteins encoded by Neisseria gonorrhoeae include FtsZ, FtsA, ZipA, FtsK, FtsQ, FtsI, FtsW, and FtsN...
December 12, 2017: BMC Microbiology
Yong Wei, Yudong Su, Chunlan Liu, Xiangfei Nie, Zhihai Liu, Yu Zhang, Yonghui Zhang
By combining a polymer-clad optic fiber and a vitreous-clad optic fiber, we proposed and fabricated a novel optic fiber surface plasmon resonance (SPR) sensor to conduct two-channel sensing at the same detection area. The traditional optic fiber SPR sensor has many disadvantages; for example, removing the cladding requires corrosion, operating it is dangerous, adjusting the dynamic response range is hard, and producing different resonance wavelengths in the sensing area to realize a multi-channel measurement is difficult...
December 9, 2017: Sensors
Min Shen, Amit Joshi, Raghu Vannam, Chandra Dixit, Robert Hamilton, Challa V Kumar, James F Rusling, Mark Wayne Peczuh
Peanut allergy can be life-threatening and is mediated by allergen-specific immunoglobulin E (IgE) antibodies. Investigation of IgE antibody binding to allergenic epitopes identifies specific interactions underlying the allergic response. Here we report a surface plasmon resonance imaging (SPRi) immunoassay for differentiating IgE antibodies by epitope resolved detection. IgE antibodies are first captured by magnetic beads bearing IgE ε-chain specific antibodies and then introduced to an SPRi array immobilized with epitopes from the major peanut allergen glycoprotein Arachis hypogaea h2 (Ara h2)...
December 12, 2017: Chembiochem: a European Journal of Chemical Biology
Nan Lu, Yaqi Wang, Shiqi Ning, Wenjing Zhao, Min Qian, Ying Ma, Jia Wang, Lingyun Fan, Jiunian Guan, Xing Yuan
A series of plasmonic Ag-TiO2/H3PW12O40 composite films were fabricated and immobilized by validated preparation technique. The chemical composition and phase, optical, SPR effect and pore-structure properties together with the morphology of as-prepared composite film are well-characterized. The multi-synergies of as-prepared composite films were gained by combined action of electron-capture action via H3PW12O40, visible-response induced by Ag, and Schottky-junction formed between TiO2-Ag. Under simulated sunlight, the maximal K app of o-chlorophenol (o-CP) reached 0...
December 11, 2017: Scientific Reports
Xintian Shen, Zhibo Zhu, Yi Ding, Wenjiao Wu, Jie Yang, Shuwen Liu
Background and Objectives Recently influenza pandemic outbreaks were caused by emerging H5N1H7N9 and H1N1 viruses. However, virucidal disinfectants are mainly unspecific and toxic. It is tactical to discover specific virucidal compounds. METHODS: The inhibitory potency was determined in H5N1 pseudovirus system; Interactions of compounds with hemagglutinin(HA) were detected with surface plasmon resonance (SPR) and further calculated with molecular docking. Virucidal effect was also estimated in influenza virus A/Puerto Rico/8/34(H1N1)...
December 8, 2017: Biochimica et Biophysica Acta
Clive L Baveghems, Murali Anuganti, Ajith Pattammattel, Yao Lin, Challa V Kumar
Using glucose oxidase (GOx) and α-Zr(IV)phosphate nanoplates (α-ZrP) as a model system, a generally applicable approach to control enzyme-solid interactions via chemical modification of amino acid side chains of the enzyme is demonstrated. Net charge on GOx was systematically tuned by appending different amounts of polyamine to the protein surface to produce chemically modified GOx(n), where n is the net charge on the enzyme after the modification and ranged from -62 to +95 electrostatic units in the system...
December 11, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
Fuming Sang, Xin Li, Zhizhou Zhang, Jia Liu, Guofu Chen
In this work, a rapid, simple and sensitive colorimetric sensor for simultaneous (or respective) detection of Cr3+ and Pb2+ using tyrosine functionalized gold nanoparticles (AuNPsTyr) has been developed. Tyrosine, a natural and zwitterionic amino acid, could be as a reducing and capping agent to synthesise AuNPs and allow for the simultaneous and selective detection of Cr3+ and Pb2+. Upon the addition of Cr3+ or Pb2+ (a combination of them), the color of AuNPsTyr solution changes from red to blue grey and the characteristic surface plasmon resonance (SPR) band is red-shifted to 580nm due to the aggregation of AuNPs...
November 27, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Liang Zhang, Zefeng Zhang, Rongrong Sun, Shuang Liang, Guang-Hao Chen, Feng Jiang
Sulfur reduction is a promising alternative to sulfate reduction as it can generate sulfide at a low cost for the precipitation of heavy metals or autotrophic denitrification in wastewater treatment. However, the extremely low water solubility of elemental sulfur limits its bioavailability and results in a low sulfur-reduction rate. Polysulfide, which is naturally generated through reactions between sulfur and sulfide, can enhance the bioavailability of sulfur and thus contribute to high-rate sulfur reduction...
November 28, 2017: Water Research
Wenguo Zhu, Linqing Zhuo, Mengjiang Jiang, Heyuan Guan, Jianhui Yu, Huihui Lu, Yunhan Luo, Jun Zhang, Zhe Chen
The spin splitting of light beams carrying orbital angular momentum (OAM) is investigated theoretically in attenuated internal reflection in the Kretschmann configuration. The excitation of the surface plasmon resonance (SPR) can significantly enhance the OAM-induced Imbert-Fedorov (IF) shift and the OAM-dependent spin splitting. The cooperation effect of these two shifts will result in an asymmetric spin splitting, which varies with the incident angle and polarization state. Specially, at the SPR angle, the OAM-induced IF shift vanishes, and the OAM-dependent spin splitting will cause a symmetric spin splitting...
December 1, 2017: Optics Letters
Raghupathi Neelarapu, Jordany R Maignan, Cynthia L Lichorowic, Andrii Monastyrskyi, Tina S Mutka, Alexis N LaCrue, Lynn D Blake, Debora Casandra, Sherwin Mashkouri, Jeremy N Burrows, Paul A Willis, Dennis E Kyle, Roman Manetsch
Malaria deaths have been decreasing over the last 10-15 years, with global mortality rates having fallen by 47% since 2000. While the World Health Organization (WHO) recommends the use of artemisinin-based combination therapies (ACTs) to combat malaria, the emergence of artemisinin resistant strains underscores the need to develop new antimalarial drugs. Recent in vivo efficacy improvements of the historical antimalarial ICI 56,780 have been reported, however with the poor solubility and rapid development of resistance, this compound requires further optimization...
December 7, 2017: Journal of Medicinal Chemistry
Leon Avakyan, Maximilian Heinz, Anna Skidanenko, Kirill A Yablunovskiy, Jürgen Ihlemann, Jörg Meinertz, Christian Patzig, Manfred Dubiel, Lusegen Bugaev
Formation of localized surface plasmon resonance (SPR) spectrum of the randomly distributed gold nanoparticles in the surface layer of silicate float glass, generated and implanted by UV ArF-excimer laser irradiation of thin gold layer sputter coated on the glass surface, was studied by the T-matrix method, which enables taking into account particles agglomerates. The used experimental technique is promising to produce submicron patterns of plasmonic nanoparticles (given by laser masks or gratings) without damaging of the glass surface...
December 7, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
Khulan Sergelen, Christian Petri, Ulrich Jonas, Jakub Dostalek
The preparation and investigation of a free-standing membrane made from a composite of thermoresponsive poly(N-isopropylacrylamide) (pNIPAAm) and polystyrene nanoparticles (PS NP) with temperature-controlled permeability is reported. The method exploits the light-induced crosslinking of the photo-reactive pNIPAAm-based polymer and mechanical reinforcement of the membrane structure by the polystyrene nanoparticles. About micrometer thick layers were either directly attached to a gold surface or prepared as free-standing layers spanning over arrays of microfluidic channels with a width of about hundred microns by using template stripping...
December 6, 2017: Biointerphases
Jiangcai Wang, Weihua Lin, En Cao, Xuefeng Xu, Wenjie Liang, Xiaofang Zhang
The performance of chemical reactions has been enhanced immensely with surface plasmon resonance (SPR)-based sensors. In this review, the principle and application of SPR sensors are introduced and summarized thoroughly. We introduce the mechanism of the SPR sensors and present a thorough summary about the optical design, including the substrate and excitation modes of the surface plasmons. Additionally, the applications based on SPR sensors are described by the Raman and fluorescence spectroscopy in plasmon-driven surface catalytic reactions and the measurement of refractive index sensing, especially...
November 24, 2017: Sensors
Qiang Liu, Yun Liu, Shimeng Chen, Fang Wang, Wei Peng
A miniaturization and integration dual-channel fiber optic surface plasmon resonance (SPR) system was proposed and demonstrated in this paper. We used a yellow light-emitting diode (LED, peak wavelength 595 nm) and built-in web camera as a light source and detector, respectively. Except for the detection channel, one of the sensors was used as a reference channel to compensate nonspecific binding and physical absorption. We packaged the LED and surface plasmon resonance (SPR) sensors together, which are flexible enough to be applied to mobile devices as a compact and portable system...
December 4, 2017: Sensors
Shijie Deng, Peng Wang, Xinglong Yu
Surface plasmon resonance (SPR) is an optical sensing technique that is capable of performing real-time, label-free and high-sensitivity monitoring of molecular interactions. SPR biosensors can be divided according to their operating principles into angle-, wavelength-, intensity- and phase-interrogated devices. With their complex optical configurations, phase-interrogated SPR sensors generally provide higher sensitivity and throughput, and have thus recently emerged as prominent biosensing devices. To date, several methods have been developed for SPR phase interrogation, including heterodyne detection, polarimetry, shear interferometry, spatial phase modulation interferometry and temporal phase modulation interferometry...
December 5, 2017: Sensors
Wenjia Wang, Zhigang Mai, Yuzhi Chen, Jiaqi Wang, Liang Li, Qingning Su, Xuejin Li, Xueming Hong
A highly sensitive and label-free fiber optic surface plasmon resonance (SPR) biosensor for specific detection of C-reactive protein (CRP) is proposed and demonstrated. We take dopamine as a cross-linking agent to immobilize the anti-CRP monoclonal antibody, which is an efficient and simple method for specific modification of the fiber optic SPR sensor. The modified sensor can successfully detect CRP specifically. We realize the fabrication of a disposable fiber optic SPR sensor for the CRP specific detection...
December 4, 2017: Scientific Reports
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