Stephan Ellmerich, Katalin Takacs, Marcin Mycko, Hanspeter Waldner, Faisal Wahid, Rosemary J Boyton, Paul A Smith, Sandra Amor, David Baker, David A Hafler, Vijay K Kuchroo, Daniel M Altmann
While EAE has been an invaluable model for the immunopathogenesis of multiple sclerosis, it has sometimes been difficult to bridge the gap between findings and therapies in the rodent models and the cellular and molecular interactions that can be studied in the human disease. Humanized transgenic models offer a means of achieving this, through the expression of disease-implicated HLA class II molecules, co-expressed with a cognate HLA-class II-restricted, myelin-specific TCR derived from a human T cell clone implicated in disease...
July 2004: European Journal of Immunology