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Manal Abdul-Hamid, Sanaa Rida Gallaly
The study aims to investigate the protective effect of Pimpinella anisum oil on aspartame (ASP) which resulted in cerebellar changes. The rats were divided into four equal groups: Group 1: (control group): served as control animals. Group 2: control P. anisum oil received .5 mL/kg/d/b wt. once daily. Group 3 (ASP group): received daily 250 mg/kg/b wt. of ASP dissolved in distilled water and given orally to the animals by intra-gastric tube for 2 months. Group 4: received .5 mL/kg/b wt. of prophylactic P...
May 2014: Ultrastructural Pathology
Stephan Ellmerich, Katalin Takacs, Marcin Mycko, Hanspeter Waldner, Faisal Wahid, Rosemary J Boyton, Paul A Smith, Sandra Amor, David Baker, David A Hafler, Vijay K Kuchroo, Daniel M Altmann
While EAE has been an invaluable model for the immunopathogenesis of multiple sclerosis, it has sometimes been difficult to bridge the gap between findings and therapies in the rodent models and the cellular and molecular interactions that can be studied in the human disease. Humanized transgenic models offer a means of achieving this, through the expression of disease-implicated HLA class II molecules, co-expressed with a cognate HLA-class II-restricted, myelin-specific TCR derived from a human T cell clone implicated in disease...
July 2004: European Journal of Immunology
J L Trotter, C L Wegescheide, W F Garvey, W W Tourtellotte
Using radioimmunoassays (RIA) for the myelin specific proteins, myelin proteolipid protein (PLP) and myelin basic protein (MBP) and an enzyme assay for the activity of the myelin marker enzyme 2'3' cyclic-3' phosphohydrolase (CNPase), we have studied plaque, periplaque and normal appearing white matter (NAWM) tissue. We found that all three mylein proteins are decreased in all regions, including NAWM, of MS brain, with a decreasing gradient from NAWM to perregion. Surprisingly, when the ratios of the proteins were calculated, MBP activity, although decreased was found to be relatively preserved...
January 1984: Neurochemical Research
R C Wiggins, J A Benjamins, P Morell
Rats between 5 and 45 days of age were sacrificed and their sciatic nerves dissected. Myelin was prepared from these sciatic nerves by a procedure involving purification on discontinuous sucrose gradients. The proteins of whole sciatic nerves at different ages and the proteins derived from the myelin isolated from these sciatic nerves were examined by discontinuous polyacrylamide gel electrophoresis in buffers containing sodium dodecyl sulfate. Over half of the proteins of sciatic nerve myelin migrated in a single band on the gel (P0)...
May 16, 1975: Brain Research
Y Konishi, S Kamoshita
A girl aged 8 years and 10 months at death had shown signs of a slowly progressive neurological disease with onset in early infancy. The main clinical features were nystagmus, spastic paraplegia, amd mental deterioration. Pathological examination of the brain showed severe demyelination with perivascular preservation of mylein islands, presenting a tigroid pattern. The patient is the second case of classical Pelizaeus-Merzbacher's disease in Japan proven by autopsy.
1975: Acta Neuropathologica
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