keyword
https://read.qxmd.com/read/38532957/evaluation-of-fecal-inflammatory-biomarkers-to-identify-bacterial-diarrhea-episodes-systematic-review-and-protocol-for-the-enterics-for-global-health-shigella-surveillance-study
#21
JOURNAL ARTICLE
Courtney Babb, Henry Badji, Md Taufiqur Rahman Bhuiyan, Jennifer Cornick, Sonia Qureshi, Catherine Sonye, Wagner V Shapiama Lopez, Mehreen Adnan, Hannah E Atlas, Kehkashan Begum, Stephanie A Brennhofer, Bubacarr E Ceesay, Abdoulie K Ceesay, Nigel A Cunliffe, Paul F Garcia Bardales, Shahinur Haque, Bri'Anna Horne, M Jahangir Hossain, Junaid Iqbal, Md Taufiqul Islam, Sadia Islam, Farhana Khanam, Karen L Kotloff, Thandizo Malemia, Katia Manzanares Villanueva, Gertrude Malola Million, Vitumbiko Munthali, John Benjamin Ochieng, Billy Ogwel, Maribel Paredes Olortegui, Richard Omore, Patricia B Pavlinac, James A Platts-Mills, Khandra T Sears, Ousman Secka, Sharon M Tennant, Pablo Peñataro Yori, Mohammad Tahir Yousafzai, Khuzwayo C Jere, Margaret N Kosek, Stephen Munga, Usman N Ikumapayi, Firdausi Qadri, Farah Naz Qamar, Elizabeth T Rogawski McQuade
BACKGROUND: The measurement of fecal inflammatory biomarkers among individuals presenting to care with diarrhea could improve the identification of bacterial diarrheal episodes that would benefit from antibiotic therapy. We reviewed prior literature in this area and describe our proposed methods to evaluate 4 biomarkers in the Enterics for Global Health (EFGH) Shigella surveillance study. METHODS: We systematically reviewed studies since 1970 from PubMed and Embase that assessed the diagnostic characteristics of inflammatory biomarkers to identify bacterial diarrhea episodes...
March 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38532703/transplant-of-microbiota-from-crohn-s-disease-patients-to-germ-free-mice-results-in-colitis
#22
JOURNAL ARTICLE
Irshad Ali Sheikh, Jared Bianchi-Smak, Daniel Laubitz, Gabriele Schiro, Monica T Midura-Kiela, David G Besselsen, Gayatri Vedantam, Sara Jarmakiewicz, Rafał Filip, Fayez K Ghishan, Nan Gao, Pawel R Kiela
Although the role of the intestinal microbiota in the pathogenesis of inflammatory bowel disease (IBD) is beyond debate, attempts to verify the causative role of IBD-associated dysbiosis have been limited to reports of promoting the disease in genetically susceptible mice or in chemically induced colitis. We aimed to further test the host response to fecal microbiome transplantation (FMT) from Crohn's disease patients on mucosal homeostasis in ex-germ-free (xGF) mice. We characterized and transferred fecal microbiota from healthy patients and patients with defined Crohn's ileocolitis (CD_L3) to germ-free mice and analyzed the resulting microbial and mucosal homeostasis by 16S profiling, shotgun metagenomics, histology, immunofluorescence (IF) and RNAseq analysis...
2024: Gut Microbes
https://read.qxmd.com/read/38532592/-application-value-of-laparoscopic-double-stapler-firings-and-double-stapling-technique-combined-with-rectal-eversion-and-total-extra-abdominal-resection-in-the-sphincter-preserving-resection-of-low-rectal-cancer
#23
JOURNAL ARTICLE
H Liang, K Q Wu, Q W Fan, W Zheng, H Zhang, J W Bai, J M Li, J Q Chen, C Zhang
Objectives: To investigate the application value of laparoscopic double stapler firings and double stapling technique combined with rectal eversion and total extra-abdominal resection (LDER) in the anal preservation treatment of low rectal cancer. Methods: Inclusion criteria: (1) age was 18-70; (2) the distance of the lower tumor edge from the anal verge was 4-5 cm; (3) primary tumor with a diameter ≤3 cm; (4) preoperative staging of T1~2N1~2M0; (5) "difficult pelvis", defined as ischial tuberosity diameter<10 cm or body mass index>25 kg/m2 ; (6) patients with strong intention for sphincter preservation; (7) no preoperative treatment (e...
March 25, 2024: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://read.qxmd.com/read/38531966/lacidophilin-tablets-alleviate-constipation-through-regulation-of-intestinal-microflora-by-promoting-the-colonization-of-akkermansia-sps
#24
JOURNAL ARTICLE
Denglong Sun, Jingting Yu, Yang Zhan, Xiaoying Cheng, Jingwen Zhang, Yingmeng Li, Qiong Li, Yanxia Xiong, Wenjun Liu
Constipation is a major health problem worldwide that requires effective and safe treatment options. Increasing evidence indicates that disturbances in gut microbiota may be a risk factor for constipation. Administration of lacidophilin tablets shows promising therapeutic potential in the treatment of inflammatory bowel disease owing to their immunomodulatory properties and regulation of the gut microbiota. The focus of this study was on investigating the ability of lacidophilin tablets to relieve constipation by modulating the gut microbiome...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38531957/microcirculation-driven-mitochondrion-dysfunction-during-the-progression-of-experimental-sepsis
#25
JOURNAL ARTICLE
Roland Fejes, Attila Rutai, László Juhász, Marietta Zita Poles, Andrea Szabó, József Kaszaki, Mihály Boros, Szabolcs Péter Tallósy
Sepsis is accompanied by a less-known mismatch between hemodynamics and mitochondrial respiration. We aimed to characterize the relationship and time dependency of microcirculatory and mitochondrial functions in a rodent model of intraabdominal sepsis. Fecal peritonitis was induced in rats, and multi-organ failure (MOF) was evaluated 12, 16, 20, 24 or 28 h later (n = 8/group, each) using rat-specific organ failure assessment (ROFA) scores. Ileal microcirculation (proportion of perfused microvessels (PPV), microvascular flow index (MFI) and heterogeneity index (HI)) was monitored by intravital video microscopy, and mitochondrial respiration (OxPhos) and outer membrane (mtOM) damage were measured with high-resolution respirometry...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38531874/profiling-the-colonic-mucosal-response-to-fecal-microbiota-transplantation-identifies-a-role-for-gbp5-in-colitis-in-humans-and-mice
#26
JOURNAL ARTICLE
Laurence D W Luu, Abhimanu Pandey, Sudarshan Paramsothy, Chinh Ngo, Natalia Castaño-Rodríguez, Cheng Liu, Michael A Kamm, Thomas J Borody, Si Ming Man, Nadeem O Kaakoush
Host molecular responses to fecal microbiota transplantation (FMT) in ulcerative colitis are not well understood. Here, we profile the human colonic mucosal transcriptome prior to and following FMT or placebo to identify molecules regulated during disease remission. FMT alters the transcriptome above the effect of placebo (n = 75 vs 3 genes, q < 0.05), including modulation of structural, metabolic and inflammatory pathways. This response is attributed to responders with no consistency observed in non-responders...
March 26, 2024: Nature Communications
https://read.qxmd.com/read/38531428/molecular-characterization-of-cryptosporidium-spp-and-giardia-duodenalis-in-pet-cats-in-henan-province-central-china
#27
JOURNAL ARTICLE
Liangliang Li, Yuzhen Sui, Xinmiao Li, Pengtao Song, Guizhen Chen, Hu Liu, Shoujun Zuo, Jinjie Guo, Qiong Wang, Qiyuan Sun, Hongyu Dai, Junqiang Li, Tao Zhang, Fang Liu, Longxian Zhang, Haiju Dong
Cryptosporidium spp. and G. duodenalis often infect humans, cats, and other mammals, causing diarrhea and being responsible for numerous outbreaks of waterborne and foodborne infections worldwide. The rapid increase in the number of pet cats poses a substantial public health risk. However, there were few reports about the infection of Cryptosporidium spp. and G. duodenalis infections in pet cats in Henan Province, central China. Thus, to understand the prevalence and genetic distribution of Cryptosporidium spp...
March 24, 2024: Acta Tropica
https://read.qxmd.com/read/38531144/the-gut-microbiome-from-middle-aged-women-with-depression-modulates-depressive-like-behaviors-and-plasma-fatty-acid-metabolism-in-female-middle-aged-mice
#28
JOURNAL ARTICLE
Huan Yu, Wen-Mao Yang, Yi-Huan Chen, Lin Guo, Rui Li, Fen Xue, Qing-Rong Tan, Zheng-Wu Peng
BACKGROUND: Intestinal dysbacteriosis has frequently been involved in the context of depression. Nonetheless, only scant information is available about the features and functional changes of gut microbiota in female middle-aged depression (MAD). OBJECTIVE: This study aims to explore whether there are characteristic changes in the gut microbes of female MAD and whether these changes are associated with depressive-like behaviors. Meanwhile, this study observed alterations in the lipid metabolism function of gut microbes and further examined changes in plasma medium- and long-chain fatty acids (MLCFAs) in mice that underwent fecal microbiota transplantation (FMT)...
March 21, 2024: Journal of Psychiatric Research
https://read.qxmd.com/read/38531068/real-world-effectiveness-of-ustekinumab-in-ulcerative-colitis-in-a-united-states-multicenter-cohort-consortium
#29
JOURNAL ARTICLE
Andres J Yarur, Ryan Ungaro, Katherine Huang, Wenfei Wang, Priya Sasankan, Mir Zulqarnain, Amanda M Johnson, Geoffrey Bader, Carl Kay, Nicholas Costable, David Dulaney, Marc Fenster, Poonam Beniwal-Patel, Gaurav Syal, Anish Patel, Edward Loftus, Joel Pekow, Benjamin Cohen, Parakkal Deepak
BACKGROUND: Pivotal trials have shown that ustekinumab is effective in ulcerative colitis (UC). However, the population included in these trials do not represent the cohort of patients treated in the real world. In this study, we aimed to describe the effectiveness and safety of ustekinumab in a clinical cohort of patients with UC. METHODS: We performed a multicenter retrospective cohort study and included patients with active UC starting ustekinumab. Variables collected included demographics, clinical data, and disease activity (measured using partial Mayo score [PMS] and endoscopic Mayo score) at follow-up...
March 26, 2024: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38530925/village-settlements-in-mountainous-tropical-areas-hotspots-of-fecal-contamination-as-evidenced-by-escherichia-coli-and-stanol-concentrations-in-stormwater-pulses
#30
JOURNAL ARTICLE
Laurie Boithias, Emilie Jardé, Keooudone Latsachack, Chanthanousone Thammahacksa, Norbert Silvera, Bounsamay Soulileuth, Mose Xayyalart, Marion Viguier, Alain Pierret, Emma Rochelle-Newall, Olivier Ribolzi
Fecal bacteria in surface water may indicate threats to human health. Our hypothesis is that village settlements in tropical rural areas are major hotspots of fecal contamination because of the number of domestic animals usually roaming in the alleys and the lack of fecal matter treatment before entering the river network. By jointly monitoring the dynamics of Escherichia coli and of seven stanol compounds during four flood events (July-August 2016) at the outlet of a ditch draining sewage and surface runoff out of a village of Northern Lao PDR, our objectives were (1) to assess the range of E...
March 26, 2024: Environmental Science & Technology
https://read.qxmd.com/read/38530362/staining-blindly-%C3%A2-an-update-on-coloring-techniques-for-fecal-smears-in-parasitology-a-scoping-review
#31
REVIEW
Saulo Hudson Nery Loiola, Vitória Castilho Stéfano, Stefany Laryssa Rosa, Letícia Rodrigues Proença, Bianca Martins Dos Santos, Felipe Augusto Soares, Katia Denise Saraiva Bresciani, Alexandre Xavier Falcão, Jancarlo Ferreira Gomes
Dye application for parasite highlighting in the Ova and Parasite exam is a common practice in parasitology diagnosis. Methods: A scoping review investigated how staining solutions interact with parasite structures. After screening 1334 papers, 35 met eligibility criteria. Results: Differentiating background from foreground in the fecal smear under light microscopy is the core of the research on this topic. Refractivity, unevenness of staining, size and temperature were explored to enhance staining protocols...
March 26, 2024: Future Microbiology
https://read.qxmd.com/read/38530358/gender-affirming-hormone-therapy-preserves-skeletal-maturation-in-young-mice-via-the-gut-microbiome
#32
JOURNAL ARTICLE
Subhashis Pal, Xochitl Morgan, Hamid Y Dar, Camilo Anthony Gacasan, Sanchiti Patil, Andreea Stoica, Yi-Juan Hu, M Neale Weitzmann, Rheinallt M Jones, Roberto Pacifici
Gender affirming hormone therapy (GAHT) is often prescribed to transgender (TG) adolescents to alleviate gender dysphoria, but the impact of GAHT on the growing skeleton is unclear. We found GAHT to improve trabecular bone structure via increased bone formation in young male mice and not to affect trabecular structure in female mice. GAHT modified gut microbiome composition in both male and female mice. However, fecal microbiota transfers (FMT) revealed that GAHT-shaped gut microbiome was a communicable regulator of bone structure and turnover in male, but not in female mice...
March 26, 2024: Journal of Clinical Investigation
https://read.qxmd.com/read/38530212/prevalence-of-intestinal-trichomonads-in-captive-non-human-primates-in-china
#33
JOURNAL ARTICLE
Ping-Ping Ma, Yang Zou, Wen-Jie Mu, Yue-Yue Zhang, Ya-Qi Li, Zhong-Li Liu, Long Zhang, Li-Xian Chen, Guo-Hua Liu, Shuai Wang
Trichomonads are protozoan symbionts with the capacity to infect vertebrates including humans and non-human primates (NHPs), sometimes with pathogenic effects. However, their diversity and prevalence in NHPs in China are poorly understood. A total of 533 fecal samples were collected from captive NHPs in Yunnan Province, China, of which 461 samples from Macaca fascicularis and 72 from Macaca mulatta. Trichomonadidae species were identified using PCR amplification of the ITS-1/5.8S/ITS-2 sequences. The overall prevalence of trichomonads in NHPs was determined to be 11...
2024: Parasite: Journal de la Société Française de Parasitologie
https://read.qxmd.com/read/38530054/microbiota-from-human-infants-consuming-secretors-or-non-secretors-mothers-milk-impacts-the-gut-and-immune-system-in-mice
#34
JOURNAL ARTICLE
Manoj Gurung, Brent Thomas Schlegel, Dhivyaa Rajasundaram, Renee Fox, Lars Bode, Tianming Yao, Stephen R Lindemann, Tanya LeRoith, Quentin D Read, Christy Simecka, Laura Carroll, Aline Andres, Laxmi Yeruva
UNLABELLED: Maternal secretor status is one of the determinants of human milk oligosaccharides (HMOs) composition, which, in turn, influences the gut microbiota composition of infants. To understand if this change in gut microbiota impacts immune cell composition, intestinal morphology, and gene expression, 21-day-old germ-free C57BL/6 mice were transplanted with fecal microbiota from infants whose mothers were either secretors (SMM) or non-secretors (NSM) or from infants consuming dairy-based formula (MFM)...
March 26, 2024: MSystems
https://read.qxmd.com/read/38529939/scavenging-glyoxal-and-methylglyoxal-by-synephrine-and-neohesperidin-from-flowers-of-citrus-aurantium-l-var-amara-engl-in-mice-and-humans
#35
JOURNAL ARTICLE
Yu Liang, Xinyu Zhao, Yujia Xu, Yonglin Lu, Lishuang Lv
There is considerable research evidence that α-dicarbonyl compounds, including glyoxal (GO) and methylglyoxal (MGO), are closely related to many chronic diseases. In this work, after comparison of the capture capacity, reaction pathway, and reaction rate of synephrine (SYN) and neohesperidin (NEO) on GO/MGO in vitro , experimental mice were administrated with SYN and NEO alone and in combination. Quantitative data from UHPLC-QQQ-MS/MS revealed that SYN/NEO/HES (hesperetin, the metabolite of NEO) could form the GO/MGO-adducts in mice (except SYN-MGO), and the levels of GO/MGO-adducts in mouse urine and fecal samples were dose-dependent...
March 26, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38529601/disruptions-of-gut-microbiota-are-associated-with-cognitive-deficit-of-preclinical-alzheimer-s-disease-a-cross-sectional-study
#36
JOURNAL ARTICLE
Binbin Yu, Guomeng Wan, Shupeng Cheng, Pengcheng Wen, Xi Yang, Jiahuan Li, Huifang Tian, Yaxin Gao, Qian Zhong, Jin Liu, Jianan Li, Yi Zhu
BACKGROUND: Alzheimer's Disease (AD) is the most prevalent type of dementia. The early change of gut microbiota is a potential biomarker for preclinical AD patients. OBJECTIVE: The study aimed to explore changes in gut microbiota characteristics in preclinical AD patients, including those with Subjective Cognitive Decline (SCD) and Mild Cognitive Impairment (MCI), and detect the correlation between gut microbiota characteristics and cognitive performances. METHODS: This study included 117 participants [33 MCI, 54 SCD, and 30 Healthy Controls (HC)]...
March 25, 2024: Current Alzheimer Research
https://read.qxmd.com/read/38529363/evaluation-of-a-microencapsulated-form-of-zinc-oxide-on-weanling-pig-growth-performance-fecal-zinc-excretion-and-small-intestinal-morphology
#37
JOURNAL ARTICLE
Payton L Dahmer, Cassandra K Jones, Franco M Ferreyra
A total of 300 pigs (DNA 200 × 400; initially 6.0 ± 0.08 kg body weight [ BW ]) were used in a 42-d study to evaluate a microencapsulated form of zinc oxide. At weaning, pigs were randomly allocated to pens, and pens were randomly assigned to dietary treatments with 5 pigs per pen and 12 pens per treatment. Dietary treatments were 1) negative control (CON; standard nursery diet containing 110 ppm Zn in the form of zinc sulfate from trace mineral premix); 2) control diet with 400 ppm added Zn from ZnO included in phases 1 and 2 (Low-ZnO); 3) control diet with 3,000 ppm added Zn from ZnO included in phase 1 and 2,000 ppm added Zn from ZnO included in phase 2 (High-ZnO); 4) control diet with 400 ppm added Zn from microencapsulated ZnO included in phases 1 and 2 (Low-MZnO; Vetagro S...
2024: Translational Animal Science
https://read.qxmd.com/read/38529272/mannose-enhances-intestinal-immune-barrier-function-and-dextran-sulfate-sodium-salt-induced-colitis-in-mice-by-regulating-intestinal-microbiota
#38
JOURNAL ARTICLE
Yi Yang, Qiming Ma, Qingyu Wang, Lifeng Zhao, Hengshan Liu, Yanjun Chen
BACKGROUND: Inflammatory bowel disease (IBD) greatly affects human quality of life. Mannose has been reported to be used to treat IBD, but the mechanism is currently unknown. METHODS: C57/BL mice were used as research subjects, and the mouse acute colitis model was induced using dextran sulfate sodium salt (DSS). After oral administration of mannose, the body weights and disease activity index (DAI) scores of the mice were observed. The colon lengths, histopathological sections, fecal content microbial sequencing, colon epithelial inflammatory genes, and tight junction protein Occludin-1 expression levels were measured...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38529122/the-perilous-consequences-of-bowel-preparation-a-case-study-with-literature-review-of-boerhaave-syndrome
#39
Ruo-Yu Gao, Xiao-Lan Wei, Jin-Feng Wu, Zhi-Wei Zhou, Xi-Qiu Yu
Colonoscopy is widely acknowledged as a prevalent and efficacious approach for the diagnosis and treatment of gastrointestinal disorders. In order to guarantee an effective colonoscopy, it is imperative for patients to undergo an optimal bowel preparation regimen. This entails the consumption of a substantial volume of a non-absorbable solution to comprehensively purge the colon of any fecal residue. Nevertheless, it is noteworthy to acknowledge that the bowel preparation procedure may occasionally elicit adverse symptoms such as nausea and vomiting...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38529070/retrospective-subgroup-analysis-of-fecal-microbiota-live-jslm-rebyota-%C3%A2-administered-by-colonoscopy-under-enforcement-discretion-for-the-prevention-of-recurrent-clostridioides-difficile-infection
#40
JOURNAL ARTICLE
Whitfield L Knapple, David S Yoho, Alexander Sheh, Joan Thul, Paul Feuerstadt
BACKGROUND: Fecal microbiota, live-jslm (RBL; REBYOTA® ), is the first Food and Drug Administration (FDA)-approved, single-dose, rectally administered, microbiota-based live biotherapeutic product for preventing Clostridioides difficile infection (CDI) recurrence. Alternative routes of administration are of clinical interest. OBJECTIVES: Evaluate the safety and efficacy of RBL administration via colonoscopy. DESIGN: Retrospective analysis of electronic medical records of participants administered RBL via colonoscopy under FDA enforcement discretion...
2024: Therapeutic Advances in Gastroenterology
keyword
keyword
10104
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.