Preeti Moar, Kyaw Linn, Thomas A Premeaux, Scott Bowler, Urvinder Kaur Sardarni, Bindu Parachalil Gopalan, Ei E Shwe, Thidar San, Haymar Han, Danielle Clements, Chaw S Hlaing, Ei H Kyu, Cho Thair, Yi Y Mar, Nway Nway, Julie Mannarino, Jacob Bolzenius, Soe Mar, Aye Mya M Aye, Ravi Tandon, Robert Paul, Lishomwa C Ndhlovu
OBJECTIVE: Adolescents with perinatally-acquired HIV (AWH) are at an increased risk of poor cognitive development but the underlying mechanisms remain unclear. Circulating galectin-9 (Gal-9) has been associated with increased inflammation and multi-morbidity in adults with HIV despite anti-retroviral therapy (ART), however, relationship between Gal-9 in AWH and cognition remain unexplored. DESIGN: A cross-sectional study of two independent age-matched cohorts from India [AWH on ART (n = 15), ART-naïve (n = 15), and adolescents without HIV (AWOH; n = 10)] and Myanmar [AWH on ART (n = 54) and AWOH (n = 22)] were studied...
April 12, 2024: AIDS