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https://www.readbyqxmd.com/read/28749597/a-structural-model-of-nitro-porphyrin-dyes-based-on-spectroscopy-and-density-functional-theory
#1
Christopher Farley, Amit Aggarwal, Sunaina Singh, Aaron Dolor, Philip To, Alexander Falber, Maxwell Crossley, Charles Michael Drain
Nitro-porphyrins are an important class of commercial dyes with a range of potential applications. The nitro group is known to dramatically affect the photophysics of the porphyrin, but there are few systematic investigations of the contributing factors. To address this deficiency, we present spectroscopic studies of a series of nitro-porphyrins, accompanied by density functional theory calculations to elucidate their structures. In particular, we explore how the positions of the substituents affect the energy levels and nuclear geometry...
July 27, 2017: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/28749508/linking-hygroscopicity-and-the-surface-microstructure-of-model-inorganic-salts-simple-and-complex-carbohydrates-and-authentic-sea-spray-aerosol-particles
#2
Armando D Estillore, Holly S Morris, Victor W Or, Hansol D Lee, Michael R Alves, Meagan A Marciano, Olga Laskina, Zhen Qin, Alexei V Tivanski, Vicki H Grassian
Individual airborne sea spray aerosol (SSA) particles show diversity in their morphologies and water uptake properties that are highly dependent on the biological, chemical, and physical processes within the sea subsurface and the sea surface microlayer. In this study, hygroscopicity data for model systems of organic compounds of marine origin mixed with NaCl are compared to data for authentic SSA samples collected in an ocean-atmosphere facility providing insights into the SSA particle growth, phase transitions and interactions with water vapor in the atmosphere...
July 27, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28749440/optimization-of-detection-accuracy-of-closed-loop-optical-voltage-sensors-based-on-pockels-effect
#3
Wei Deng, Hui Li, Chunxi Zhang, Pengjie Wang
The influence of optical parameters on the performance of closed-loop optical voltage sensors (OVSs) based on Pockels effect is analyzed and a control algorithm is proposed to suppress the nonlinearity caused by the unideal parameters of optical devices for optimizing the detection precision of OVSs. First, a quantified model of the feedback phase demonstrates how the optical parameters of optical devices (including light source, polarizer, 45° fusion point, Faraday rotator and half-wave plate) result in the nonlinearity of closed-loop OVSs...
July 27, 2017: Sensors
https://www.readbyqxmd.com/read/28749429/establishment-of-a-site-specific-tropospheric-model-based-on-ground-meteorological-parameters-over-the-china-region
#4
Chongchong Zhou, Bibo Peng, Wei Li, Shiming Zhong, Jikun Ou, Runjing Chen, Xinglong Zhao
China is a country of vast territory with complicated geographical environment and climate conditions. With the rapid progress of the Chinese BeiDou satellite navigation system (BDS); more accurate tropospheric models must be applied to improve the accuracy of navigation and positioning. Based on the formula of the Saastamoinen and Callahan models; this study develops two single-site tropospheric models (named SAAS_S and CH_S models) for the Chinese region using radiosonde data from 2005 to 2012. We assess the two single-site tropospheric models with radiosonde data for 2013 and zenith tropospheric delay (ZTD) data from four International GNSS Service (IGS) stations and compare them to the results of the Saastamoinen and Callahan models...
July 27, 2017: Sensors
https://www.readbyqxmd.com/read/28749428/cannabinoid-receptor-1-and-fatty-acid-amide-hydrolase-contribute-to-operant-sensation-seeking-in-mice
#5
Alexander I Helfand, Christopher M Olsen, Cecilia J Hillard
A large body of evidence in humans and preclinical models supports a role for the endocannabinoid system in the proper execution of motivated or goal-directed behaviors. Operant sensation seeking (OSS) is a task that uses varied sensory stimuli as a reinforcer to maintain operant responding in mice. The purpose of the studies in this report was to begin to explore the role of endocannabinoid signaling in OSS utilizing cannabinoid receptor 1 (CB1R) and fatty acid amide hydrolase (FAAH) knock out mice. Compared to wild type littermate controls, CB1R knock out mice exhibited significantly fewer active responses and earned significantly fewer reinforcers in fixed ratio and progressive ratio schedules...
July 27, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28749416/anti-oxidative-stress-activity-is-essential-for-amanita-caesarea-mediated-neuroprotection-on-glutamate-induced-apoptotic-ht22-cells-and-an-alzheimer-s-disease-mouse-model
#6
Zhiping Li, Xia Chen, Wenqian Lu, Shun Zhang, Xin Guan, Zeyu Li, Di Wang
Amanita caesarea, an edible mushroom found mainly in Asia and southern Europe, has been reported to show good antioxidative activities. In the present study, the neuroprotective effects of A. caesarea aqueous extract (AC) were determined in an l-glutamic acid (l-Glu) induced HT22 cell apoptosis model, and in a d-galactose (d-gal) and AlCl₃-developed experimental Alzheimer's disease (AD) mouse model. In 25 mM of l-Glu-damaged HT22 cells, a 3-h pretreatment with AC strongly improved cell viability, reduced the proportion of apoptotic cells, restored mitochondrial function, inhibited the over-production of intracellular reactive oxygen species (ROS) and Ca(2+), and suppressed the high expression levels of cleaved-caspase-3, calpain 1, apoptosis-inducing factor (AIF) and Bax...
July 27, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28749375/towards-fast-online-intrafraction-replanning-for-free-breathing-stereotactic-body-radiation-therapy-with-the-mr-linac
#7
Charis Kontaxis, Gijsbert H Bol, Bjorn Stemkens, Markus Glitzner, Fieke M Prins, Linda G W Kerkmeijer, Jan J W Lagendijk, Bas W Raaymakers
The hybrid MRI-radiotherapy machines, like the MR-linac (Elekta AB, Stockholm, Sweden) installed at the UMC Utrecht (Utrecht, The Netherlands), will be able to provide real-time patient imaging during treatment. In order to take advantage of the system's capabilities and enable online adaptive treatments, a new generation of software should be developed, ranging from motion estimation to treatment plan adaptation. In this work we present a proof of principle adaptive pipeline designed for high precision Stereotactic Body Radiation Therapy (SBRT) suitable for sites affected by respiratory motion, like Renal Cell Carcinoma (RCC)...
July 27, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28749363/distributed-parametric-consensus-optimization-with-an-application-to-model-predictive-consensus-problem
#8
Xinli Shi, Jinde Cao, Wei Huang
In this paper, we study a special class of distributed convex optimization problems--distributed parametric consensus optimization problem (DPCOP), for which a two-stage optimization method including primal decomposition and distributed consensus is provided. Different from traditional distributed optimization problems driving all the local states to a common value, DPCOP aims to solve a system-wide problem with partial common parameters shared amongst local agents in a distributed way. To relax the restriction on the topology, a distributed projected subgradient method is applied in distributed consensus stage to achieve the consensus of local estimated parameters, while the subgradients can be obtained by solving a multiparametric problem locally...
July 25, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28749345/noise-in-neuronal-and-electronic-circuits-a-general-modeling-framework-and-non-monte-carlo-simulation-techniques
#9
Deniz Kilinc, Alper Demir
The brain is extremely energy efficient and remarkably robust in what it does despite the considerable variability and noise caused by the stochastic mechanisms in neurons and synapses. Computational modeling is a powerful tool that can help us gain insight into this important aspect of brain mechanism. A deep understanding and computational design tools can help develop robust neuromorphic electronic circuits and hybrid neuroelectronic systems. In this paper, we present a general modeling framework for biological neuronal circuits that systematically captures the nonstationary stochastic behavior of ion channels and synaptic processes...
August 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28749296/bridging-gaps-between-zoo-and-wildlife-medicine-establishing-reference-intervals-for-free-ranging-african-lions-panthera-leo
#10
Heather M Broughton, Danny Govender, Purvance Shikwambana, Patrick Chappell, Anna Jolles
The International Species Information System has set forth an extensive database of reference intervals for zoologic species, allowing veterinarians and game park officials to distinguish normal health parameters from underlying disease processes in captive wildlife. However, several recent studies comparing reference values from captive and free-ranging animals have found significant variation between populations, necessitating the development of separate reference intervals in free-ranging wildlife to aid in the interpretation of health data...
June 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28749286/detection-of-aerosolized-bacteria-in-expired-air-samples-from-asian-elephants-elephas-maximus
#11
Sophie M Burke, Larry Vogelnest, Paul Thompson, Euan R Tovey, Peter Williamson
Elephant-mediated transmission of tuberculosis is assumed to be similar to human models, which state close and prolonged contact with an infected individual is required for transmission. Although considered a risk factor for infection, several case studies have reported that close contact with an elephant is not always necessary for transmission, and the role of aerosolized bacteria remains unclear. To investigate aerosol-mediated transmission of pathogenic bacteria from elephants, a method for the detection of aerosols using an adapted sampling system was developed...
June 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28749163/development-of-a-paediatric-head-voxel-model-database-for-dosimetric-applications
#12
Andreas Stratis, Nathan Touyz, Guozhi Zhang, Reinhilde Jacobs, Ria Bogaerts, Hilde Bosmans
OBJECTIVES: To develop a database of paediatric head voxel models intended for Monte Carlo (MC) dosimetric applications. METHODS: Seventeen head and neck CT image datasets were retrieved from the Picture Archiving and Communicating System (PACS) of our hospital and were reformed into voxel models. Twenty two organs were segmented at each dataset. The segmented organ masses were compared to the respective age and gender specific ICRP reference mass value. Adjustments were made such that segmented and reference mass values coincide within a tolerance of 10%...
July 27, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28748989/-association-of-abo-blood-groups-with-gestational-diabetes-mellitus
#13
Andrea Huidobro M, Demetrio Torres C, Fabio Paredes
BACKGROUND: ABO and Rhesus blood systems are associated with type 2 Diabetes Mellitus (DM2). Gestational Diabetes (GDM) is a model to study DM. AIM: To study the association between GDM and ABO and Rhesus groups. MATERIAL AND METHODS: A retrospective cohort study was performed in 1,078 women who gave birth to a singleton in Talca Regional Hospital, Chile, during 2008. We analyzed personal, obstetric, medical data and ABO and Rh blood groups...
April 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/28748911/a-novel-and-quick-pcr-based-method-to-genotype-mice-with-a-leptin-receptor-mutation-db-db-mice
#14
Bao-Yu Peng, Qiang Wang, Yan-Hong Luo, Jian-Feng He, Tao Tan, Hua Zhu
db/db mice is one of most widely used animal models in studying the cellular and molecular mechanisms of metabolic disorders, such as diabetes, hyperlipidemia, and obesity. The mice carry spontaneous point mutations in the gene encoding the leptin receptor, leading to leptin receptor inactivation. Since homozygous db/db mice are sterile, the maintenance of db/db mice requires breeding between heterozygous pairs, which makes genotyping essential for the identification of offspring. The aim of this study was to develop a quick and highly repeatable method for genotyping db/db mice, which comprised only three simple steps: Genomic DNA is extracted from either tail tips or ear notches via alkaline lysis (∼20 min); Samples are then subjected to tetra-primer amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) using specially designed and validated primer sets (∼1...
July 27, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28748857/effect-of-high-fat-diet-induced-disorders-on-rat-with-endometrial-hyperplasia-and-adiponectin-system-in-circulation-and-uterus
#15
Chen-Guang Shang, Zhao-Hui Liu, Xiao-Hui Wang, Zong-Hao Feng, Yan Zhang
BACKGROUND: Epidemiologic and genetic studies suggest a link between insulin resistance (IR) and endometrial cancer, and endometrial hyperplasia (EH) is a precancerous stage of endometrial cancer. Adiponectin is an adipokine which previously shown to be a risk factor for endometrial cancer. The aim of the study was to develop a rat model of IR and EH and evaluate adiponectin system in circulation and uterus. METHODS: This study was a 46-week animal trial from February 2014 to January 2015...
August 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28748770/management-of-diabetic-surgical-patients-in-a-deployed-field-hospital-a-model-for-acute-non-communicable-disease-care-in-disaster
#16
Kathleen M McDermott, Ruth M Hardstaff, Sophie Alpen, David J Read, Nicholas R Coatsworth
Sudden onset disasters (SODs) have affected over 1.5 billion of the world's population in the past decade. During the same time, developing nations have faced a sustained increase in the burden of non-communicable disease (NCD) with extra pressure placed on health systems. The combined increase in SODs and the NCD epidemic facing the world's most disaster-prone nations will present new challenges to emergency medical teams (EMTs) during disaster response. This report details the experience as an EMT during the Typhoon Haiyan disaster of 2013, with particular reference to the challenges of diabetic management in a surgical field hospital...
July 27, 2017: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/28748755/biotin-and-glutathione-targeting-of-solid-nanoparticles-to-cross-human-brain-endothelial-cells
#17
Szilvia Veszelka, Mária Mészáros, Lóránd Kiss, Zoltán Kóta, Tibor Páli, Zsófia Hoyk, Zsolt Bozsó, Lívia Fülöp, András Tóth, Gábor Rákhely, Mária A Deli
Background The blood-brain barrier restricts drug penetration to the central nervous system. Targeted nanocarriers are new potential tools to increase the brain entry of drugs. Ligands of endogenous transporters of the blood-brain barrier can be used as targeting vectors for brain delivery of nanoparticles. Objective We tested biotin-labeled solid nanoparticles for the first time and compared to biotinylated glutathione-labeled nanoparticles in brain endothelial cells. Method Neutravidin coated fluorescent polystyrene nanoparticles were derivatized with biotin and biotinylated glutathione...
July 27, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28748698/band-gap-engineering-of-titania-film-through-cobalt-regulation-for-oxidative-damage-of-bacteria-respiration-and-viability
#18
Jinhua Li, Jiaxing Wang, Donghui Wang, Geyong Guo, Kelvin Wai Kwok Yeung, Xianlong Zhang, Xuanyong Liu
Biomaterial-related bacterial infections cause patient suffering, mortality and extended periods of hospitalization, and impose a substantial burden on medical systems. In this context, understanding the interactions between nanomaterials and bacteria is clinically significant. Herein, TiO2-based heterojunctions including Co-TiO2, CoO-TiO2 and Co3O4-TiO2, were firstly designed by optimizing magnetron sputtering to establish a platform to explore the interactions between nanomaterials and bacteria. We found that the energy band bending and band gap narrowing were effectively promoted at the contact interface of the heterojunctions, which have the ability to induce abiotic reactive oxygen species formation...
July 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28748697/portable-lock-in-amplifier-based-electrochemical-method-to-measure-an-array-of-64-sensors-for-point-of-care-applications
#19
Radim Hrdý, Hana Kynclová, Ivana Klepáčová, Martin Bartosik, Pavel Neuzil
We present a portable lock-in amplifier-based electrochemical sensing system. The basic unit (cluster) consists of four electrochemical cells (EC), each containing one pseudo-reference electrode (PRE) and one working electrode (WE). All four ECs are simultaneously interrogated, each at different frequency, with square wave pulses superposed on a sawtooth signal for cyclic voltammetry (CV). Lock-in amplification provides independent read-out of four signals, with excellent noise suppression. We expanded a single cluster system into an array of 16 clusters by using electronic switches...
July 27, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28748587/from-risk-and-harm-reduction-to-decriminalizing-abortion-the-uruguayan-model-for-women-s-rights
#20
Leonel Briozzo
OBJECTIVE: To describe public policies, social actions, particularly those of obstetricians/gynecologists, and changes in abortion-related legislation in the different historical periods between 1990 and 2015, and to analyze temporal correlations with a reduction in maternal mortality. METHODS: The 1990-2015 period was divided into three different stages to permit evaluation of the legislation, health regulations, healthcare system, and professional practices related to the care provided in cases of unsafe abortion: 1990-2001, characterized by illegality and the healthcare system's denial of abortion; 2001-2012, when the model for reducing the risk and harm of unsafe abortions was developed; and 2012-2015, when abortion was finally decriminalized...
August 2016: International Journal of Gynaecology and Obstetrics
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