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MST1 inhibitor

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https://www.readbyqxmd.com/read/27618557/mst1-mst2-protein-kinases-regulation-and-physiologic-roles
#1
Jacob A Galan, Joseph Avruch
The MST1 and MST2 protein kinases comprise the GCK-II subfamily of protein kinases. In addition to their amino-terminal kinase catalytic domain, related to that of the Saccharomyces cerevisiae protein kinase Ste20, their most characteristic feature is the presence near the carboxy terminus of a unique helical structure called a SARAH domain; this segment allows MST1/MST2 to homodimerize and to heterodimerize with the other polypeptides that contain SARAH domains, the noncatalytic polypeptides RASSF1-6 and Sav1/WW45...
October 4, 2016: Biochemistry
https://www.readbyqxmd.com/read/27535619/pharmacological-targeting-of-kinases-mst1-and-mst2-augments-tissue-repair-and-regeneration
#2
Fuqin Fan, Zhixiang He, Lu-Lu Kong, Qinghua Chen, Quan Yuan, Shihao Zhang, Jinjin Ye, Hao Liu, Xiufeng Sun, Jing Geng, Lunzhi Yuan, Lixin Hong, Chen Xiao, Weiji Zhang, Xihuan Sun, Yunzhan Li, Ping Wang, Lihong Huang, Xinrui Wu, Zhiliang Ji, Qiao Wu, Ning-Shao Xia, Nathanael S Gray, Lanfen Chen, Cai-Hong Yun, Xianming Deng, Dawang Zhou
Tissue repair and regenerative medicine address the important medical needs to replace damaged tissue with functional tissue. Most regenerative medicine strategies have focused on delivering biomaterials and cells, yet there is the untapped potential for drug-induced regeneration with good specificity and safety profiles. The Hippo pathway is a key regulator of organ size and regeneration by inhibiting cell proliferation and promoting apoptosis. Kinases MST1 and MST2 (MST1/2), the mammalian Hippo orthologs, are central components of this pathway and are, therefore, strong target candidates for pharmacologically induced tissue regeneration...
August 17, 2016: Science Translational Medicine
https://www.readbyqxmd.com/read/27053234/mst1-a-promising-therapeutic-target-to-restore-functional-beta-cell-mass-in-diabetes
#3
REVIEW
Amin Ardestani, Kathrin Maedler
The loss of insulin-producing beta cells by apoptosis is a hallmark of all forms of diabetes mellitus. Strategies to prevent beta cell apoptosis and dysfunction are urgently needed to restore the insulin-producing cells and to prevent severe diabetes progression. We recently identified the serine/threonine kinase known as mammalian sterile 20-like kinase 1 (MST1) as a critical regulator of apoptotic beta cell death and dysfunction. MST1 activates several apoptotic signalling pathways, which further stimulate its own cleavage, leading to a vicious cycle of cell death...
September 2016: Diabetologia
https://www.readbyqxmd.com/read/26657153/deacetylation-of-tumor-suppressor-mst1-in-hippo-pathway-induces-its-degradation-through-hbxip-elevated-hdac6-in-promotion-of-breast-cancer-growth
#4
L Li, R Fang, B Liu, H Shi, Y Wang, W Zhang, X Zhang, L Ye
Reduction or loss of tumor-suppressor mammalian STE20-like kinase 1 (MST1) in Hippo pathway contributes to the tumorigenesis. However, the mechanism leading to reduction of MST1 in cancers remains poorly understood. In this study, we explored the hypothesis that the oncoprotein hepatitis B X-interacting protein (HBXIP) is involved in the reduction of MST1 in breast cancer. Immunohistochemical analysis of tissue microarrays revealed that the expression of HBXIP was negatively associated with that of MST1 in 98 clinical breast tissue samples...
August 4, 2016: Oncogene
https://www.readbyqxmd.com/read/26538561/mammalian-sterile-20-like-kinase-1-mst1-enhances-the-stability-of-forkhead-box-p3-foxp3-and-the-function-of-regulatory-t-cells-by-modulating-foxp3-acetylation
#5
Jiang Li, Xingrong Du, Hao Shi, Kejing Deng, Hongbo Chi, Wufan Tao
Regulatory T cells (Tregs) play crucial roles in maintaining immune tolerance. The transcription factor Foxp3 is a critical regulator of Treg development and function, and its expression is regulated at both transcriptional and post-translational levels. Acetylation by lysine acetyl transferases/lysine deacetylases is one of the main post-translational modifications of Foxp3, which regulate Foxp3's stability and transcriptional activity. However, the mechanism(s) by which the activities of these lysine acetyl transferases/lysine deacetylases are regulated to preserve proper Foxp3 acetylation during Treg development and maintenance of Treg function remains to be determined...
December 25, 2015: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/26269600/modulator-of-apoptosis-1-moap-1-is-a-tumor-suppressor-protein-linked-to-the-rassf1a-protein
#6
Jennifer Law, Mohamed Salla, Alaa Zare, Yoke Wong, Le Luong, Natalia Volodko, Orysya Svystun, Kayla Flood, Jonathan Lim, Miranda Sung, Jason R B Dyck, Chong Teik Tan, Yu-Chin Su, Victor C Yu, John Mackey, Shairaz Baksh
Modulator of apoptosis 1 (MOAP-1) is a BH3-like protein that plays key roles in cell death or apoptosis. It is an integral partner to the tumor suppressor protein, Ras association domain family 1A (RASSF1A), and functions to activate the Bcl-2 family pro-apoptotic protein Bax. Although RASSF1A is now considered a bona fide tumor suppressor protein, the role of MOAP-1 as a tumor suppressor protein has yet to be determined. In this study, we present several lines of evidence from cancer databases, immunoblotting of cancer cells, proliferation, and xenograft assays as well as DNA microarray analysis to demonstrate the role of MOAP-1 as a tumor suppressor protein...
October 2, 2015: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/26265440/a-novel-hmga1-ccne2-yap-axis-regulates-breast-cancer-aggressiveness
#7
Silvia Pegoraro, Gloria Ros, Yari Ciani, Riccardo Sgarra, Silvano Piazza, Guidalberto Manfioletti
High Mobility Group A1 (HMGA1) is an architectural chromatin factor that promotes neoplastic transformation and progression. However, the mechanism by which HMGA1 exerts its oncogenic function is not fully understood. Here, we show that cyclin E2 (CCNE2) acts downstream of HMGA1 to regulate the motility and invasiveness of basal-like breast cancer cells by promoting the nuclear localization and activity of YAP, the downstream mediator of the Hippo pathway. Mechanistically, the activity of MST1/2 and LATS1/2, the core kinases of the Hippo pathway, are required for the HMGA1- and CCNE2-mediated regulation of YAP localization...
August 7, 2015: Oncotarget
https://www.readbyqxmd.com/read/26260799/cardiac-protein-kinases-the-cardiomyocyte-kinome-and-differential-kinase-expression-in-human-failing-hearts
#8
Stephen J Fuller, Sally A Osborne, Sam J Leonard, Michelle A Hardyman, George Vaniotis, Bruce G Allen, Peter H Sugden, Angela Clerk
AIMS: Protein kinases are potential therapeutic targets for heart failure, but most studies of cardiac protein kinases derive from other systems, an approach that fails to account for specific kinases expressed in the heart and the contractile cardiomyocytes. We aimed to define the cardiomyocyte kinome (i.e. the protein kinases expressed in cardiomyocytes) and identify kinases with altered expression in human failing hearts. METHODS AND RESULTS: Expression profiling (Affymetrix microarrays) detected >400 protein kinase mRNAs in rat neonatal ventricular myocytes (NVMs) and/or adult ventricular myocytes (AVMs), 32 and 93 of which were significantly up-regulated or down-regulated (greater than two-fold), respectively, in AVMs...
October 1, 2015: Cardiovascular Research
https://www.readbyqxmd.com/read/24852423/genetic-deletion-of-mst1-alters-t-cell-function-and-protects-against-autoimmunity
#9
Konstantin V Salojin, Brian D Hamman, Wei Chun Chang, Kanchan G Jhaver, Amin Al-Shami, Jeannette Crisostomo, Carrie Wilkins, Ann Marie Digeorge-Foushee, Jason Allen, Nita Patel, Suma Gopinathan, Julia Zhou, Amr Nouraldeen, Theodore C Jessop, Jeffrey T Bagdanoff, David J Augeri, Robert Read, Peter Vogel, Jonathan Swaffield, Alan Wilson, Kenneth A Platt, Kenneth G Carson, Alan Main, Brian P Zambrowicz, Tamas Oravecz
Mammalian sterile 20-like kinase 1 (Mst1) is a MAPK kinase kinase kinase which is involved in a wide range of cellular responses, including apoptosis, lymphocyte adhesion and trafficking. The contribution of Mst1 to Ag-specific immune responses and autoimmunity has not been well defined. In this study, we provide evidence for the essential role of Mst1 in T cell differentiation and autoimmunity, using both genetic and pharmacologic approaches. Absence of Mst1 in mice reduced T cell proliferation and IL-2 production in vitro, blocked cell cycle progression, and elevated activation-induced cell death in Th1 cells...
2014: PloS One
https://www.readbyqxmd.com/read/24732633/gemcitabine-induced-pancreatic-cancer-cell-death-is-associated-with-mst1-cyclophilin-d-mitochondrial-complexation
#10
Shao-Hua Chen, Dong-Liang Li, Fang Yang, Zhe Wu, Yong-Yang Zhao, Yi Jiang
The pancreatic adenocarcinoma remains the most aggressive human malignancy with an extremely low 5-year overall survival. Postoperative gemcitabine could significantly delay recurrence after complete resection of pancreatic cancer. However, the underlying mechanisms are not fully understood. The chemo-resistance factors against gemcitabine still need further characterizations. Here we studied the mechanism of gemcitabine-induced pancreatic cancer cell death by focusing on mammalian sterile 20-like kinase 1 (MST1) and cyclophilin D (Cyp-D)...
August 2014: Biochimie
https://www.readbyqxmd.com/read/24710534/effects-of-mtor-inhibitors-on-components-of-the-salvador-warts-hippo-pathway
#11
Jonathan Chiang, Julian A Martinez-Agosto
The MST/Salvador-Warts-Hippo and mTOR/Akt/PI3K growth signaling pathways have been established as important modulators of cell growth, proliferation and cell survival in controlling organ size in Drosophila and mammals. Here, we sought to determine the role of the MST family of kinases, some of which are components of the Hippo pathway, and their closely related Sterile 20-like kinases (STK) as candidates for mediating cross-talk between the Hippo and mTOR pathways. Expression analysis in the HepG2 and MCF7 cell lines demonstrated common expression of MST1/2/4, MAP4K3/4/5, STK 24 (MST3), STK25, STK39, Pak1, SLK, Stradα/β and TAO2...
2012: Cells
https://www.readbyqxmd.com/read/24499724/overexpression-of-myc-and-ezh2-cooperates-to-epigenetically-silence-mst1-expression
#12
Gamze Kuser-Abali, Ahmet Alptekin, Bekir Cinar
Hippo-like MST1 protein kinase regulates cell growth, organ size, and carcinogenesis. Reduction or loss of MST1 expression is implicated in poor cancer prognosis. However, the mechanism leading to MST1 silencing remains elusive. Here, we report that both MYC and EZH2 function as potent suppressors of MST1 expression in human prostate cancer cells. We demonstrated that concurrent overexpression of MYC and EZH2 correlated with the reduction or loss of MST1 expression, as shown by RT-qPCR and immunoblotting. Methylation sensitive PCR and bisulfite genomic DNA sequencing showed that DNA methylation caused MST1 silencing...
April 2014: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/24464935/the-role-of-reciprocal-activation-of-cabl-and-mst1-in-the-oxidative-death-of-cultured-astrocytes
#13
Sook-Jeong Lee, Bo-Ra Seo, Eui-Ju Choi, Jae-Young Koh
The protein kinase Mst1 (mammalian Sterile 20-like kinase 1) likely plays a role in oxidative neuronal cell death as a target of its activator, cAbl. We previously found that H2O2-induced death of astrocytes is mediated by cAbl in a metallothionein-3 (Mt3)-dependent manner. In the present study, we examined a possible role for Mst1 in the oxidative death of astrocytes. Treatment of cortical astrocytes with 170 µM H2O2 activated Mst1. Knockdown of Mst1 reduced H2O2-induced cell death, indicating that Mst1 activation contributes to astrocytic cell death...
April 2014: Glia
https://www.readbyqxmd.com/read/24341623/a-combination-of-silac-and-nucleotide-acyl-phosphate-labelling-reveals-unexpected-targets-of-the-rsk-inhibitor-bi-d1870
#14
Alexander J Edgar, Matthias Trost, Colin Watts, Rossana Zaru
Protein kinase inhibitors frequently have interesting effects that cannot be fully ascribed to the intended target kinase(s) but identifying additional targets that might explain the effects is not straightforward. By comparing two different inhibitors of the Rsk kinases we found that the increasingly used compound BI-D1870 had biological effects in murine dendritic cells (DCs) that could not be solely ascribed to Rsk or other documented targets. We assessed the ability of BI-D1870 and a second Rsk inhibitor, BIX 02565 to protect enzyme active sites from reaction with biotinylated nucleotide acyl phosphates...
December 17, 2013: Bioscience Reports
https://www.readbyqxmd.com/read/24077602/scaffold-attachment-factor-b1-an-intrinsic-inhibitor-of-androgen-receptor-downregulated-in-prostate-cancer
#15
Haojie Huang
The androgen receptor (AR) is a pleiotrophic transcription factor that regulates expression of a large number of genes involved in many diverse cellular processes. The AR activation pathways have been studied extensively. However, the molecular mechanism and biological significance of AR inhibitory signals remain poorly understood. Mukhopadhyay et al. have now identified the nuclear matrix protein scaffold attachment factor B1 (SAFB1) as a novel AR corepressor. The authors found that SAFB1 physically associates with AR protein and inhibits AR transcriptional activity and androgen-sensitive gene expression...
November 2013: Asian Journal of Andrology
https://www.readbyqxmd.com/read/24043211/whole-genome-expression-profiling-and-screening-for-differentially-expressed-cytokine-genes-in-human-bone-marrow-endothelial-cells-treated-with-humoral-inhibitors-in-liver-cirrhosis
#16
Bo Gao, Wang Sun, Xianqi Wang, Xu Jia, Biao Ma, Yu Chang, Weihui Zhang, Dongbo Xue
Bone marrow endothelial cells (BMECs) are important components of the hematopoietic microenvironment in bone marrow, and they can secrete several types of cytokines to regulate the functions of hematopoietic stem/progenitor cells. To date, it is unknown whether BMECs undergo functional changes and lead to hematopoietic abnormalities in cases of liver cirrhosis (LC). In the present study, whole genome microarray analysis was carried out to detect differentially expressed genes in human BMECs treated for 48 h with medium supplemented with 20% pooled sera from 26 patients with LC or 10 healthy volunteers as the control group...
November 2013: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/23972470/structural-basis-for-autoactivation-of-human-mst2-kinase-and-its-regulation-by-rassf5
#17
Lisheng Ni, Sheng Li, Jianzhong Yu, Jungki Min, Chad A Brautigam, Diana R Tomchick, Duojia Pan, Xuelian Luo
The tumor-suppressive Hippo pathway controls tissue homeostasis through balancing cell proliferation and apoptosis. Activation of the kinases Mst1 and Mst2 (Mst1/2) is a key upstream event in this pathway and remains poorly understood. Mst1/2 and their critical regulators RASSFs contain Salvador/RASSF1A/Hippo (SARAH) domains that can homo- and heterodimerize. Here, we report the crystal structures of human Mst2 alone and bound to RASSF5. Mst2 undergoes activation through transautophosphorylation at its activation loop, which requires SARAH-mediated homodimerization...
October 8, 2013: Structure
https://www.readbyqxmd.com/read/23928732/mst1-overexpression-inhibited-the-growth-of-human-non-small-cell-lung-cancer-in-vitro-and-in-vivo
#18
C M Xu, W W Liu, C J Liu, C Wen, H F Lu, F S Wan
Mammalian STE20-like kinase 1 (Mst1) ubiquitously encodes serine threonine kinase, which is a 59-kDa class II GC kinase that shares 76% identity in amino-acid sequence with MST2, and is the closest mammalian homolog of Drosophila Hippo protein kinase, a major inhibitor of cell proliferation in Drosophila. Recent studies have shown that Mst1 and Mst2 perform tumor-suppressor function in a redundant manner and were originally identified as pro-apoptotic cytoplasmic kinases important for controlling cell growth, proliferation, apoptosis and organ size...
August 2013: Cancer Gene Therapy
https://www.readbyqxmd.com/read/23792360/msp-ron-signalling-in-cancer-pathogenesis-and-therapeutic-potential
#19
REVIEW
Hang-Ping Yao, Yong-Qing Zhou, Ruiwen Zhang, Ming-Hai Wang
Since the discovery of MSP (macrophage-stimulating protein; also known as MST1 and hepatocyte growth factor-like (HGFL)) as the ligand for the receptor tyrosine kinase RON (also known as MST1R) in the early 1990s, the roles of this signalling axis in cancer pathogenesis has been extensively studied in various model systems. Both in vitro and in vivo evidence has revealed that MSP-RON signalling is important for the invasive growth of different types of cancers. Currently, small-molecule inhibitors and antibodies blocking RON signalling are under investigation...
July 2013: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/23647599/protein-l-isoaspartate-d-aspartate-o-methyltransferase-protects-cardiomyocytes-against-hypoxia-induced-apoptosis-through-inhibiting-proapoptotic-kinase-mst1
#20
Guijun Yan, Qing Qin, Bing Yi, Kurt Chuprun, Haixiang Sun, Shengdong Huang, Jianxin Sun
BACKGROUND: Mammalian sterile 20-like kinase 1 (Mst1) is a mammalian homolog of Hippo kinase from Drosophila and it is a critical component of the Hippo signaling pathway, which regulates a variety of biological processes ranging from cell contact inhibition, organ size control, apoptosis and tumor suppression in mammals. Mst1 plays essential roles in heart disease since its activation causes cardiomyocyte apoptosis and dilated cardiomyopathy. However, the mechanism underlying Mst1 activation in the heart is not known...
October 9, 2013: International Journal of Cardiology
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