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https://www.readbyqxmd.com/read/28330826/the-influence-of-methamphetamine-on-maternal-behavior-and-development-of-the-pups-during-the-neonatal-period
#1
Mária Ševčíková, Ivana Hrebíčková, Eva Macúchová, Romana Šlamberová
Since it enters breast milk, methamphetamine (MA) abuse during lactation can not only affect the quality of maternal behavior but also postnatal development of pups. The aim of the present study was to examine the effect of injected MA (5mg/kg) on maternal behavior of rats and the differences in postnatal development, during postnatal days (PD) 1-11, of pups when the pups were directly exposed (i.e., injected) to MA or received MA indirectly via breast milk. Maternal behavior was examined using observation test (PD 1-22) and pup retrieval test (PD 1-12)...
March 18, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28327154/the-effect-of-social-behavior-change-communication-package-on-maternal-knowledge-in-obstetric-danger-signs-among-mothers-in-east-mamprusi-district-of-ghana
#2
Mahama Saaka, Paul Aryee, Robert Kuganab-Lem, Mohammed Ali, Abdul Razak Masahudu
BACKGROUND: An understanding of maternal knowledge of the danger signs of obstetric and newborn complications is fundamental to attaining universal health coverage. In Northern Ghana, where maternal and newborn morbidity and mortality is high, little is known about the current knowledge level and associated determinants of these danger signs. This study assessed the effect of social behavior change communication (SBCC) package on knowledge of obstetric and newborn danger signs among mothers with children under 24 months of age...
March 21, 2017: Globalization and Health
https://www.readbyqxmd.com/read/28325525/clinical-heterogeneity-of-glycine-encephalopathy-in-three-palestinian-siblings-a-novel-mutation-in-the-glycine-decarboxylase-gldc-gene
#3
Waseem Khraim, Bassam Abu-Libdeh, Suhail Ayesh, Imad Dweikat
INTRODUCTION: Glycine encephalopathy (GE), also known as non-ketotic hyperglycinemia (NKH), is a rare inborn error of glycine metabolism caused by a defect in glycine cleavage system, a multi-enzyme complex located in mitochondrial membrane. This defect results in elevated glycine concentration in plasma and cerebrospinal fluid (CSF). Clinical manifestations vary from severe lethargy, hypoactivity and apneic episodes in the neonatal form, mild or moderate psychomotor delay and seizures in the infantile form, and abnormal behaviors, ataxia and choreoathetoid movements in late onset form...
March 18, 2017: Brain & Development
https://www.readbyqxmd.com/read/28324897/neonatal-feeding-behavior-as-a-complex-dynamical-system
#4
Eugene C Goldfield, Jennifer Perez, Katherine Engstler
The requirements of evidence-based practice in 2017 are motivating new theoretical foundations and methodological tools for characterizing neonatal feeding behavior. Toward that end, this article offers a complex dynamical systems perspective. A set of critical concepts from this perspective frames challenges faced by speech-language pathologists and allied professionals: when to initiate oral feeds, how to determine the robustness of neonatal breathing during feeding and appropriate levels of respiratory support, what instrumental assessments of swallow function to use with preterm neonates, and whether or not to introduce thickened liquids...
April 2017: Seminars in Speech and Language
https://www.readbyqxmd.com/read/28320565/handshake-free-zone-in-a-neonatal-intensive-care-unit-initial-feasibility-study
#5
Joanna J Parga, Maria Valadez, Ruey-Kang R Chang, Anahit Sarin-Gulian, Heaven Holdbrooks, Mark S Sklansky
BACKGROUND: The handshake represents a social custom with special importance in health care settings. However, handshakes can transmit disease and compliance with hand hygiene protocols averages <50%. We hypothesized that a handshake-free zone (HFZ) could be established within our neonatal intensive care unit (NICU) and would be well-received by patient families and their health care providers (HCPs). METHODS: We established an HFZ and conducted a prospective cohort study in the NICU at 2 UCLA Medical Centers...
March 17, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28320189/tempol-4-hydroxy-tempo-inhibits-anoxia-induced-progression-of-mitochondrial-dysfunction-and-associated-neurobehavioral-impairment-in-neonatal-rats
#6
Puneet K Samaiya, Gopeshwar Narayan, Ashok Kumar, Sairam Krishnamurthy
BACKGROUND: Anoxia leads to a robust generation of reactive oxygen species/nitrogen species which can result in mitochondrial dysfunction and associated cell death in the cerebral cortex of neonates. AIM: The present study investigated the pharmacological role of tempol in the treatment of rat neonatal cortical mitochondrial dysfunction induced insult progression (day-1 to day-7) and associated neurobehavioral alterations post-anoxia. METHODS: Rat pups of 30h age or postnatal day 2 (PND2) were randomly divided into 5 groups (n=5 per group): (1) Control; (2) Anoxia; (3) Anoxia+Tempol 75mg/kg; (4) Anoxia+Tempol 150mg/kg; and (5) Anoxia+Tempol 300mg/kg, and subjected to two episode of anoxia (10min each) at 24h of time interval in an enclosed chamber supplied with 100% N2...
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28319548/tanshinone-iia-attenuates-sevoflurane-neurotoxicity-in-neonatal-mice
#7
Yimeng Xia, Heng Xu, Chenfei Jia, Xiaodong Hu, Yu Kang, Xiaoxuan Yang, Qingsheng Xue, Guorong Tao, Buwei Yu
BACKGROUND: Sevoflurane is the most widely used inhalational anesthetic in pediatric medicine. Despite this, sevoflurane has been reported to exert potentially neurotoxic effects on the developing brain. Clinical interventions and treatments for these effects are limited. Tanshinone IIA (Tan IIA), extracted from Salvia miltiorrhiza (Danshen), has been documented to alleviate cognitive decline in traditional applications. Therefore, we hypothesized that preadministration of Tan IIA may attenuate sevoflurane-induced neurotoxicity, suggesting that Tan IIA is a new and promising drug capable of counteracting the effects of cognitive dysfunction produced by general anesthetics...
April 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28318973/the-dual-nature-of-early-life-experience-on-somatosensory-processing-in-the-human-infant-brain
#8
Nathalie L Maitre, Alexandra P Key, Olena D Chorna, James C Slaughter, Pawel J Matusz, Mark T Wallace, Micah M Murray
Every year, 15 million preterm infants are born, and most spend their first weeks in neonatal intensive care units (NICUs) [1]. Although essential for the support and survival of these infants, NICU sensory environments are dramatically different from those in which full-term infants mature and thus likely impact the development of functional brain organization [2]. Yet the integrity of sensory systems determines effective perception and behavior [3, 4]. In neonates, touch is a cornerstone of interpersonal interactions and sensory-cognitive development [5-7]...
March 15, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28296079/magel2-knockout-mice-manifest-altered-social-phenotypes-and-a-deficit-in-preference-for-social-novelty
#9
Michael D Fountain, Huifang Tao, Chun-An Chen, Jiani Yin, Christian P Schaaf
MAGEL2 is one of five protein-coding, maternally imprinted, paternally expressed genes in the Prader-Willi syndrome-critical domain on chromosome 15q11-q13. Truncating pathogenic variants of MAGEL2 cause Schaaf-Yang syndrome (OMIM #615547), a neurodevelopmental disorder related to Prader-Willi syndrome. Affected individuals manifest a spectrum of neurocognitive and behavioral phenotypes, including intellectual disability and autism spectrum disorder (ASD). Magel2 knockout mice carrying a maternally inherited, imprinted wildtype allele and a paternally inherited Magel2-lacZ knock-in allele, which abolishes endogenous Magel2 gene function, exhibit several features reminiscent of the human Prader-Willi phenotypes, including neonatal growth retardation, excessive weight gain after weaning, and increased adiposity in adulthood...
March 13, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/28285734/behavioral-predictors-of-alcohol-drinking-in-a-neurodevelopmental-rat-model-of-schizophrenia-and-co-occurring-alcohol-use-disorder
#10
Jibran Y Khokhar, Travis P Todd
Alcohol use disorder commonly occurs in patients with schizophrenia and contributes greatly to its morbidity. Unfortunately, the neural and behavioral underpinnings of alcohol drinking in these patients are not well understood. In order to begin to understand the cognitive and reward-related changes that may contribute to alcohol drinking, this study was designed to address: 1) latent inhibition; 2) conditioning; and 3) extinction of autoshaping in a neurodevelopmental rat model with relevance to co-occurring schizophrenia and alcohol use disorders, the neonatal ventral hippocampal lesioned (NVHL) rat...
March 9, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28284951/hippocampal-bdnf-overexpression-or-micror124a-silencing-reduces-anxiety-and-autism-like-behaviors-in-rats
#11
Amine Bahi
MicroRNA124a (miR124a) has emerged recently as a key player for multiple neuropsychiatric disorders including depression, anxiety, alcoholism, and cocaine addiction. Although we have previously reported that miR124a and its target the brain-derived neutrophic factor (BDNF) play an important role in autism-like behaviors, the molecular and behavioral dysfunctions remain unknown. The aim of this study was to understand the effects of sustained decreases in miR124a and increases of BDNF in the dentate gyrus (DG) on neonatal isolation-induced anxiety-and autism like behaviors in rats...
March 8, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28282819/management-of-mixed-type-congenital-mesoblastic-nephroma-case-series-and-review-of-the-literature
#12
J Daniel, A Ruzic, J Dalland, V Miller, M Hanna
Congenital mesoblastic nephroma (CMN) is the most common renal tumor of infancy; however, it occurs infrequently with an incidence of 1 : 125,000. The cellular and classical variants are the most common subtypes of tumors, with a mixed variant occurring infrequently. We describe two cases of mixed variant CMN, which presented within days of each other differing in their clinical behavior. The first case followed a typical course, previously described in the literature, while the other deviated significantly...
March 4, 2017: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/28274640/clinical-predictors-of-attention-and-executive-functioning-outcomes-in-children-after-perinatal-arterial-ischemic-stroke
#13
Danielle D Bosenbark, Lauren Krivitzky, Rebecca Ichord, Arastoo Vossough, Aashim Bhatia, Laura E Jastrzab, Lori Billinghurst
BACKGROUND: Children with perinatal arterial ischemic stroke (PAIS) are at risk for later neurocognitive and behavioral deficits, yet the clinical predictors of these outcomes are understudied. We examined the influence of clinical and infarct characteristics on attention and executive functioning in children following PAIS. METHODS: Forty children born at term (≥37 weeks' gestation) with PAIS (28 with neonatal arterial ischemic stroke and 12 with presumed PAIS) underwent a comprehensive neuropsychological battery at age three to 16 years (median age 7...
January 25, 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/28273662/dedifferentiated-fat-cells-as-a-novel-source-for-cell-therapy-to-target-neonatal-hypoxic-ischemic-encephalopathy
#14
Alkisti Mikrogeorgiou, Yoshiaki Sato, Taiki Kondo, Tetsuo Hattori, Yuichiro Sugiyama, Miharu Ito, Akiko Saito, Keiko Nakanishi, Masahiro Tsuji, Tomohiko Kazama, Koichiro Kano, Taro Matsumoto, Masahiro Hayakawa
Neonatal hypoxic-ischemic (HI) encephalopathy (HIE) remains a major cause of mortality and persistent neurological disabilities in affected individuals. At present, hypothermia is considered to be the only applicable treatment option, although growing evidence suggests that cell-based therapy might achieve better outcomes. Dedifferentiated fat (DFAT) cells are derived from mature adipocytes via a dedifferentiation strategy called ceiling culture. Their abundance and ready availability might make them an ideal therapeutic tool for the treatment of HIE...
March 9, 2017: Developmental Neuroscience
https://www.readbyqxmd.com/read/28267745/disturbed-sensorimotor-and-electrophysiological-patterns-in-lead-intoxicated-rats-during-development-are-restored-by-curcumin-i
#15
Hind Benammi, Hasna Erazi, Omar El Hiba, Laurent Vinay, Hélène Bras, Jean-Charles Viemari, Halima Gamrani
Lead poisoning is one of the most significant health problem of environmental origin. It is known to cause different damages in the central and peripheral nervous system which could be represented by several neurophysiological and behavioral symptoms. In this study we firstly investigated the effect of lead prenatal exposure in rats to (3g/L), from neonatal to young age, on the motor/sensory performances, excitability of the spinal cord and gaits during development. Then we evaluated neuroprotective effects of curcumin I (Cur I) against lead neurotoxicity, by means of grasping and cliff avoidance tests to reveal the impairment of the sensorimotor functions in neonatal rats exposed prenatally to lead...
2017: PloS One
https://www.readbyqxmd.com/read/28265099/neonatal-cx26-removal-impairs-neocortical-development-and-leads-to-elevated-anxiety
#16
Xin Su, Jing-Jing Chen, Lin-Yun Liu, Qian Huang, Li-Zhao Zhang, Xiao-Yang Li, Xiang-Nan He, Wenlian Lu, Shan Sun, Huawei Li, Yong-Chun Yu
Electrical coupling between excitatory neurons in the neocortex is developmentally regulated. It is initially prominent but eliminated at later developmental stages when chemical synapses emerge. However, it remains largely unclear whether early electrical coupling networks broadly contribute to neocortical circuit formation and animal behavior. Here, we report that neonatal electrical coupling between neocortical excitatory neurons is critical for proper neuronal development, synapse formation, and animal behavior...
March 6, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28256617/cholesterol-depletion-impairs-contractile-machinery-in-neonatal-rat-cardiomyocytes
#17
Barbara Hissa, Patrick W Oakes, Bruno Pontes, Guillermina Ramírez-San Juan, Margaret L Gardel
Cholesterol regulates numerous cellular processes. Depleting its synthesis in skeletal myofibers induces vacuolization and contraction impairment. However, little is known about how cholesterol reduction affects cardiomyocyte behavior. Here, we deplete cholesterol by incubating neonatal cardiomyocytes with methyl-beta-cyclodextrin. Traction force microscopy shows that lowering cholesterol increases the rate of cell contraction and generates defects in cell relaxation. Cholesterol depletion also increases membrane tension, Ca(2+) spikes frequency and intracellular Ca(2+) concentration...
March 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28256059/gsk-3%C3%AE-inhibitor-tdzd-8-reduces-neonatal-hypoxic-ischemic-brain-injury-in-mice
#18
Sammen Huang, Haitao Wang, Ekaterina Turlova, Ahmed Abussaud, Xiang Ji, Luiz R Britto, Steven P Miller, Ana Martinez, Hong-Shuo Sun, Zhong-Ping Feng
AIMS: Glycogen synthase kinase 3β (GSK-3β) is activated following hypoxic-ischemic (HI) brain injury. TDZD-8 is a specific GSK-3β inhibitor. Currently, the impact of inhibiting GSK-3β in neonatal HI injury is unknown. We aimed to investigate the effect of TDZD-8 following neonatal HI brain injury. METHODS: Unilateral common carotid artery ligation followed by hypoxia was used to induce HI injury in postnatal day 7 mouse pups pretreated with TDZD-8 or vehicle...
March 2, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/28238611/utilization-of-the-premature-birth-knowledge-scale-to-assess-pediatric-provider-knowledge-of-neurodevelopmental-outcomes
#19
Michelle M Kelly, Spencer Dean
INTRODUCTION: Prematurity affects a significant portion (10-12%) of children in the Unites States, with potential for physical, psychological, neurodevelopmental, and behavioral impairments continuing long past the neonatal period. The specific aim of this research was to evaluate pediatric primary and specialty care providers' knowledge and understanding of neurodevelopmental outcomes of children born prematurely. METHODS: Pediatric nurse practitioner (PNP) members of the National Association of Pediatric Nurse Practitioners participated in an online survey using the 33-item Premature Birth Knowledge Scale (PB-KS) to assess their knowledge of current neurodevelopmental outcomes of children born prematurely...
February 23, 2017: Journal of Pediatric Health Care
https://www.readbyqxmd.com/read/28238550/diverse-non-genetic-allele-specific-expression-effects-shape-genetic-architecture-at-the-cellular-level-in-the-mammalian-brain
#20
Wei-Chao Huang, Elliott Ferris, Tong Cheng, Cornelia Stacher Hörndli, Kelly Gleason, Carol Tamminga, Janice D Wagner, Kenneth M Boucher, Jan L Christian, Christopher Gregg
Interactions between genetic and epigenetic effects shape brain function, behavior, and the risk for mental illness. Random X inactivation and genomic imprinting are epigenetic allelic effects that are well known to influence genetic architecture and disease risk. Less is known about the nature, prevalence, and conservation of other potential epigenetic allelic effects in vivo in the mouse and primate brain. Here we devise genomics, in situ hybridization, and mouse genetics strategies to uncover diverse allelic effects in the brain that are not caused by imprinting or genetic variation...
March 8, 2017: Neuron
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