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https://www.readbyqxmd.com/read/27900089/pregnancy-and-cesarean-delivery-after-multimodal-therapy-for-vulvar-carcinoma-a-case-report
#1
Kuniaki Toriyabe, Haruki Taniguchi, Tokihiro Senda, Masako Nakano, Yoshinari Kobayashi, Miho Izawa, Hirohiko Tanaka, Tetsuo Asakura, Tsutomu Tabata, Tomoaki Ikeda
Reports of pregnancy following treatment for vulvar carcinoma are extremely uncommon, as the main problem of subsequent pregnancy is vulvar scarring following radical surgery. We herein report the case of a patient who was diagnosed with stage I squamous cell carcinoma of the vulva at the age of 17 years and was treated with multimodal therapy, including neoadjuvant chemotherapy, wide local excision with bilateral inguinal lymph node dissection and adjuvant radiotherapy. The patient became pregnant spontaneously 9 years after her initial diagnosis and the antenatal course was good, except for mild acute pyelonephritis at 25 weeks of gestation...
November 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27897026/-acute-myocardial-infarction-complicated-pregnancy-of-patient-after-kindey-transplantation-and-knee-osteosarcoma
#2
K Lehnertová, K Huml, R Pilka
OBJECTIVE: Case report describes a patient with acute ST elevation myocardial infarction with Q wave in 26 weeks gestation. DESIGN: Case report. SETTING: Department of Obstetrics and Gynecology, University Hospital, Palacky University, Olomouc. CASE REPORT: Medical history is complicated with a cadaveric transplantation of kindey, osteosarcoma of the left knee with a joint extraction and chemotherapy, serious hypothyreosis after spontaneous discontinuation of medication and missing fetal nasal bone at the ultrasound examination...
2016: Ceská Gynekologie
https://www.readbyqxmd.com/read/27821979/comparison-of-efficacy-of-granisetron-and-promethazine-in-control-of-hyperemesis-gravidarum
#3
Ashraf Aleyasin, Elham Saffarieh, Hassan Torkamandi, Somayeh Hanafi, Fariborz Sadeghi, Atossa Mahdavi, Fatemeh Bahmaei, Mohammadreza Javadi
PURPOSE: Hyperemesis gravidarum is the third leading cause of hospitalization during pregnancy. 5-HT3-receptor antagonists are the most effective against chemotherapy-induced nausea and vomiting and radiation. This randomized study aimed to compare and evaluate the efficacies of granisetron and promethazine for controlling nausea and vomiting of pregnancy. METHODS: The included patients were administered (oral and intravenous) granisetron and promethazine randomly...
December 2016: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/27819786/-use-of-chemotherapy-during-pregnancy
#4
Denise N Benardete-Harari, Janisse Kershenovich-Gersson, Diego Meraz-Ávila, Javier Andrés Galnares-Olalde, Emilio José Olaya-Guzmán
The presence of malignant tumors during pregnancy complicates the management of both tumor and pregnancy, since any diagnostic or therapeutic intervention could imply risks that may bring on detrimental effects to fetus or mother. The risks involved in exposing a fetus to cytotoxic therapy are associated to gestational age and the time of in utero exposure to that therapy. Cancer treatment has two different objectives: local control by surgery and radiotherapy, and one that seeks to eradicate systemic disease through chemotherapy, immunotherapy, hormone therapy, or targeted therapies...
November 2016: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/27819410/comparing-and-evaluating-the-efficacy-of-methotrexate-and-actinomycin-d-as-first-line-single-chemotherapy-agents-in-low-risk-gestational-trophoblastic-disease
#5
Young Jae Lee, Jeong Yeol Park, Dae Yeon Kim, Dae Shik Suh, Jong Hyeok Kim, Yong Man Kim, Young Tak Kim, Joo Hyun Nam
OBJECTIVE: The aim of this study was to compare responses to single-agent chemotherapies and evaluate the predictive factors of resistance in low risk (LR) gestational trophoblastic disease (GTD). The chemotherapy agents included methotrexate (MTX) and actinomycin D (ACT-D). METHODS: We conducted a retrospective study of 126 patients with GTD who were treated between 2000 and 2013. A total of 71 patients with LR GTD were treated with MTX (8-day regimen or weekly regimen, n=53) or ACT-D (bi-weekly pulsed regimen or 5-day regimen, n=18)...
October 7, 2016: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/27807508/occurrence-of-lymphoma-in-non-gonadal-organ-during-pregnancy-a-report-on-four-cases-and-literature-review
#6
Da-Lin Gao, Qian-Qian Fu, Tian-Tian Zhang, Lin Sun, Yi Pan, Qiong-Li Zhai
Lymphoma rarely occurs during pregnancy, making this condition difficult to define. Lymphomas that occur in reproductive organs during pregnancy exhibit unique clinical characteristics. Among the limited cases, non-Hodgkin's lymphoma (NHL) shows a considerably higher incidence rate than Hodgkin's lymphoma (HL); NHL also displays clinical characteristics, such as high aggressiveness, advanced stage, and poor outcome. This study reports on four cases of lymphomas in non-gonadal organs (HL, n=2; NHL, n=2) during pregnancy...
September 2016: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/27802832/reproductive-issues-in-patients-undergoing-hematopoietic-stem-cell-transplantation-an-update
#7
REVIEW
Maurizio Guida, Maria Antonietta Castaldi, Rosa Rosamilio, Valentina Giudice, Francesco Orio, Carmine Selleri
In 1963 George Mathé announced to the world that he had cured a patient of leukaemia by means of a bone-marrow transplant. Since than much progress has been made and nowadays Hematopoietic Stem Cell Transplantation (HSCT) is considered the most effective treatment of numerous severe haematological diseases. Gynaecological complications in HSCT women represent a serious concern for these patients, but often underestimated by clinicians in the view of Overall Survival. The main gynaecological complications of HSCT are represented by: premature ovarian failure (POF), thrombocytopenia-associated menorrhagia, genital symptoms or sexual problems in course of chronic GVHD (cGVHD), osteoporosis, secondary solid tumours due to immunosuppressive drugs to treat cGVHD and severity of cGVHD, and fertility and pregnancy issues...
November 1, 2016: Journal of Ovarian Research
https://www.readbyqxmd.com/read/27795832/fertility-sparing-management-in-cervical-cancer-balancing-oncologic-outcomes-with-reproductive-success
#8
REVIEW
Karla Willows, Genevieve Lennox, Allan Covens
BACKGROUND: Cervical cancer is the fourth most common cancer among women worldwide, many of who are still within their reproductive lifespan. Advances in screening and treatment have increased the 5-year survival for early stage disease to over 90 % in developed countries. The focus is now shifting to reducing morbidity and improving fertility outcomes for cervical cancer patients. Radical trachelectomy with lymph node assessment became the standard of care for selected women with lesions <2 cm who desire fertility preservation...
2016: Gynecologic Oncology Research and Practice
https://www.readbyqxmd.com/read/27795792/aseptic-necrosis-of-the-femoral-head-after-pregnancy-a-case-report
#9
Kawtar Nassar, Wafae Rachidi, Saadia Janani, Ouafa Mkinsi
A documented case of beginning aseptic necrosis of the femoral head associated with pregnancy together with a review of the literature about this rare complication of pregnancy is presented. The known risk factors of osteonecrosis are; steroid use, alcoholism, organ transplantation, especially after kidney transplant or bone marrow transplantation bone, systemic lupus erythematosus, dyslipidemia especially hypertriglyceridemia, dysbaric decompression sickness, drepanocytosis and Gaucher's disease. Among the less established factors, we mention procoagulations abnormalities, HIV infection, chemotherapy...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27789086/placental-site-trophoblastic-tumors-and-epithelioid-trophoblastic-tumors-biology-natural-history-and-treatment-modalities
#10
REVIEW
Neil S Horowitz, Donald P Goldstein, Ross S Berkowitz
Placental site (PSTT) and epithelioid trophoblastic tumor (ETT) are rare types of gestational trophoblastic neoplasia (GTN) that arise from intermediate trophoblast. Given that this cell of origin is different from other forms of GTN, it is not surprising that the clinical presentation, tumor marker profile, and treatment paradigm for PSTT and ETT are quite different as well. The mainstay for therapy for stage I PSTT and ETT is hysterectomy with adjuvant chemotherapy reserved for those presenting greater than four years from the antecedent pregnancy...
October 24, 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27764854/-head-and-neck-cancer-in-pregnancy-recommendations-for-diagnosis-and-therapy-with-case-report
#11
C Mozet, T Kuhnt, B Sattler, J Remmele, U Thome, H Stepan, R Kluge, A Dietz, M Knoedler
Objective: The diagnosis of cancer in pregnancy is rare, but might become more relevant even for head and neck cancer patients due to a shift of age of primipara towards the last third of reproductive years. Unsureness exists about the risk and benefit of diagnostic and therapeutic cancer modalities for the unborn and established recommendations are still missing. But, according to recent data, even multimodal therapeutic approaches (e. g. surgery, radiation, chemotherapy) seem possible in face of pregnancy and should be traded against the risk of prematurity...
October 2016: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/27763704/the-human-serotonin-type-3-receptor-gene-htr3a-e-allelic-variant-database
#12
Jacopo Celli, Gudrun Rappold, Beate Niesler
Serotonin type 3 (5-HT3 ) receptors are ligand-gated ion channels formed by five subunits (5-HT3A-E), which are encoded by the HTR3A, HTR3B, HTR3C, HTR3D, and HTR3E genes. Functional receptors are pentameric complexes of diverse composition. Different receptor subtypes confer a predisposition to nausea and vomiting during chemotherapy, pregnancy, and following surgery. In addition, different subtypes contribute to neurogastroenterologic disorders such irritable bowel syndrome (IBS) and eating disorders as well as comorbid psychiatric conditions...
October 20, 2016: Human Mutation
https://www.readbyqxmd.com/read/27744215/solitary-lung-metastasis-from-gestational-choriocarcinoma-resected-six-years-after-hydatidiform-mole-a-case-report
#13
Yoshihito Iijima, Hirohiko Akiyama, Yuki Nakajima, Hiroyasu Kinoshita, Iwao Mikami, Hidetaka Uramoto, Tomomi Hirata
INTRODUCTION: Recently, the opportunity to encounter lung metastasis from choriocarcinoma has become very rare for thoracic surgeons, since chemotherapy works very well and the operative indications for lung metastasis are limited. PRESENTATION OF CASE: A 45-year-old woman with a past history of hydatidiform mole six years previously was found to have a nodulous chest shadow in the right middle lung field on a chest radiography. She was also suspected of having an ovarian tumor and underwent a total abdominal hysterectomy and bilateral salpingo-oophorectomy...
September 30, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27743147/continuing-dilemmas-in-the-management-of-lymphoma-during-pregnancy-review-of-a-10-point-case-based-questionnaire
#14
Amit Odelia, Joffe Erel, Perry Chava, Herishanu Yair, Sarid Nadav, Lishner Michael, Avivi Irit
INTRODUCTION: Due to the rarity of lymphoma during pregnancy, management guidelines are based upon evidence from retrospective studies and case reports. Here, we review the major dilemmas in the field and examine the approach of hemato-oncologists in Israel to the management of lymphoma in pregnancy. METHODOLOGY: We performed a literature search on the PubMed database using keywords for all papers on the subject from 1990-2014. The papers were reviewed by an expert panel who devised a questionnaire covering the main dilemmas...
October 14, 2016: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27738663/fertility-sparing-surgery-in-gestational-trophoblastic-neoplasia-a-report-of-4-cases
#15
Malihe Hasanzadeh, Ftemeh Vahid Roodsari, Shahnaz Ahmadi, Masoumeh Gavedan Mehr, Tabari Azadeh
BACKGROUND: Gestational trophoblastic neoplasia (GTN) is a curable disease that involves the development of malignant tumor in the woman after a normal or molar pregnancy. The position of surgery in GTN is not properly specified and is changing due to new chemotherapy protocols. However, the role of surgery is highlighted in chemotherapy-resistant GTN. Other indications of surgery in trophoblastic diseases are drug toxicity and uterine perforation. Based on the fact that most women in certain age tend to preserve fertility, this study reported 4 cases of successful treatment after fertility sparing surgery...
September 2016: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/27734613/pregnancy-screening-prior-to-chemotherapy-administration
#16
L Hu, G Kichenadasse, H Martin, A Roy, S Sukumaran, S Vatandoust, B Koczwara, C S Karapetis
A retrospective case notes review was performed to determine compliance with screening for undetected pregnancy prior to commencement of chemotherapy at Flinders Medical Centre. All female patients aged 18-55 who commenced chemotherapy between January and December 2014 were included. During the first 12 months, for women identified as having childbearing potential, pre-chemotherapy pregnancy screening was performed only in 40% of patients under 40 years and in 20.5% of the entire age range.
October 2016: Internal Medicine Journal
https://www.readbyqxmd.com/read/27689876/lh-prevents-cisplatin-induced-apoptosis-in-oocytes-and-preserves-female-fertility-in-mouse
#17
Valerio Rossi, Monica Lispi, Salvatore Longobardi, Maurizio Mattei, Francesca Di Rella, Antonietta Salustri, Massimo De Felici, Francesca G Klinger
Premature ovarian failure and female infertility are frequent side effects of anticancer therapies, owing to the extreme sensitivity of the ovarian reserve oocytes to the damaging effects of irradiation and chemotherapy on DNA. We report here a robust protective effect of luteinizing hormone (LH) on the primordial follicle pool of prepubertal ovaries against the cisplatin (Cs)-induced apoptosis. In vitro LH treatment of prepubertal ovarian fragments generated anti-apoptotic signals by a subset of ovarian somatic cells expressing LH receptor (LHR) through cAMP/PKA and Akt pathways...
September 30, 2016: Cell Death and Differentiation
https://www.readbyqxmd.com/read/27679689/imaging-and-clinical-data-of-placental-site-trophoblastic-tumor-a-case-report
#18
Maryam Niknejadi, Firoozeh Ahmadi, Farnaz Akhbari
Placental site trophoblastic tumor (PSTT) is a very rare variant of gestational trophoblastic tumor. It can occur after normal termination of pregnancy or spontaneous abortion and ectopic or molar pregnancy. There is a wide range of clinical manifestations from a benign condition to an aggressive disease with fatal outcome. One of the most important characteristics of PSTT, unlike other forms of gestational trophoblastic diseases (GTD) is the presence of low beta-subunit of human chorionic gonadotropin (β-hCG) levels because it is a neoplastic proliferation of intermediate trophoblastic cells...
April 2016: Iranian Journal of Radiology: a Quarterly Journal Published By the Iranian Radiological Society
https://www.readbyqxmd.com/read/27673036/poster-279-radial-neuropathy-exacerbated-by-ligamentous-laxity-in-pregnancy-and-by-chemotherapy-a-case-report
#19
Joel Castellanos, Sean R Smith
No abstract text is available yet for this article.
September 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27661036/chemotherapy-against-cancer-during-pregnancy-a-systematic-review-on-neonatal-outcomes
#20
Susanna Esposito, Rossana Tenconi, Valentina Preti, Elena Groppali, Nicola Principi
BACKGROUND: The concomitant incidence of cancer and pregnancy has increased in recent years because of the increase in maternal age at the time of the 1st pregnancy. The diagnosis of cancer in a pregnant woman causes ethical and therapeutic problems for both the patient and the physician. The main aim of this paper is to describe the available evidence concerning the short- and long-term neonatal impact of chemotherapy given to pregnant women. METHODS: The relevant publications in English were identified by a systematic review of MEDLINE and PubMed for the last 15 years...
September 2016: Medicine (Baltimore)
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