Zhen Zhang, Zhaoxue Sheng, Wuqiang Che, Shuoyan An, Di Sun, Zhengqin Zhai, Xuecheng Zhao, Yaliu Yang, Zhen Meng, Zixiang Ye, Enmin Xie, Peizhao Li, Changan Yu, Yanxiang Gao, Zhu Xiao, Yanfen Wu, Fen Dong, Jingyi Ren, Jingang Zheng
INTRODUCTION: ST-segment elevation myocardial infarction (STEMI) with high thrombus burden is associated with a poor prognosis. Manual aspiration thrombectomy reduces coronary vessel distal embolisation, improves microvascular perfusion and reduces cardiovascular deaths, but it promotes more strokes and transient ischaemic attacks in the subgroup with high thrombus burden. Intrathrombus thrombolysis (ie, the local delivery of thrombolytics into the coronary thrombus) is a recently proposed treatment approach that theoretically reduces thrombus volume and the risk of microvascular dysfunction...
November 10, 2023: BMJ Open