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https://www.readbyqxmd.com/read/28736188/asparaginase-associated-pancreatitis-in-childhood-acute-lymphoblastic-leukaemia-an-observational-ponte-di-legno-toxicity-working-group-study
#1
Benjamin O Wolthers, Thomas L Frandsen, André Baruchel, Andishe Attarbaschi, Shlomit Barzilai, Antonella Colombini, Gabriele Escherich, Kathrine Grell, Hiroto Inaba, Gábor Kovacs, Der-Cherng Liang, Marion Mateos, Veerle Mondelaers, Anja Möricke, Tomasz Ociepa, Sujith Samarasinghe, Lewis B Silverman, Inge M van der Sluis, Martin Stanulla, Lynda M Vrooman, Michihiro Yano, Ester Zapotocka, Kjeld Schmiegelow
BACKGROUND: Survival for childhood acute lymphoblastic leukaemia surpasses 90% with contemporary therapy; however, patients remain burdened by the severe toxic effects of treatment, including asparaginase-associated pancreatitis. To investigate the risk of complications and risk of re-exposing patients with asparaginase-associated pancreatitis to asparaginase, 18 acute lymphoblastic leukaemia trial groups merged data for this observational study. METHODS: Patient files from 26 trials run by 18 trial groups were reviewed on children (aged 1·0-17·9 years) diagnosed with t(9;22)-negative acute lymphoblastic leukaemia between June 1, 1996, and Jan 1, 2016, who within 50 days of asparaginase exposure developed asparaginase-associated pancreatitis...
July 20, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28733740/laparoscopic-splenopexy-for-wandering-spleen-a-video-demonstration-of-technique-by-encircling-the-spleen-with-polyglactin-910-woven-mesh
#2
Sheridan Morgan, Ian Glenn, Oliver Soldes
BACKGROUND: Wandering spleen is a rare clinical entity caused by absence of the spleen's peritoneal attachments, allowing the spleen to move freely within the peritoneal cavity [1]. This disease is most commonly seen in children and young women [1, 2]. Affected individuals are predisposed to complications including splenic torsion, splenic infarction, and pancreatic necrosis [3, 4]. Patients may present with constipation, an abdominal mass, swelling, or acute abdominal pain if splenic torsion has occurred [4]...
July 21, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28730220/verner-morrison-syndrome-literature-review
#3
Oana Andreea Belei, Elena Rodica Heredea, Estera Boeriu, Tamara Marcela Marcovici, Simona Cerbu, Otilia Mărginean, Emil Radu Iacob, Daniela Iacob, Andrei Gheorghe Marius Motoc, Eugen Sorin Boia
Chronic diarrhea in infants is a common condition for addressability to pediatric gastroenterologists. The causes are multiple and the delay in reaching the final diagnosis can lead to complications in the general condition of the child. The purpose of this review is to present the bio-clinical and histogenetic particularities of a rare clinical entity, characterized by tumoral causes of chronic diarrhea. VIPomas are neuroendocrine tumors that autonomously secrete vasoactive intestinal peptide (VIP). Watery diarrhea, hypokalemia and achlorhydria (WDHA) syndrome caused by VIP-producing tumors only rarely occurs in adult patients with non-pancreatic disease...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28726607/acute-febrile-illness-and-complications-due-to-murine-typhus-texas-usa1-2
#4
Zeeshan Afzal, Sunand Kallumadanda, Feng Wang, Vagish Hemmige, Daniel Musher
Murine typhus occurs relatively commonly in southern Texas, as well as in California. We reviewed records of 90 adults and children in whom murine typhus was diagnosed during a 3-year period in 2 hospitals in southern Texas, USA. Most patients lacked notable comorbidities; all were immunocompetent. Initial signs and symptoms included fever (99%), malaise (82%), headache (77%), fatigue (70%), myalgias (68%), and rash (39%). Complications, often severe, in 28% of patients included bronchiolitis, pneumonia, meningitis, septic shock, cholecystitis, pancreatitis, myositis, and rhabdomyolysis; the last 3 are previously unreported in murine typhus...
August 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28702868/safety-and-tolerability-of-the-ketogenic-diet-used-for-the-treatment-of-refractory-childhood-epilepsy-a-systematic-review-of-published-prospective-studies
#5
REVIEW
Qian-Yun Cai, Zhong-Jie Zhou, Rong Luo, Jing Gan, Shi-Ping Li, De-Zhi Mu, Chao-Min Wan
BACKGROUND: To review the available evidence from prospective studies on the safety and tolerability of the ketogenic diet (KD) for the treatment of refractory childhood epilepsy. METHODS: A comprehensive bibliographic search was performed with the aim of retrieving prospective studies that monitored adverse effects (AEs) in children after receiving the classic or medium-chain triglyceride KD therapy for refractory epilepsy. RESULTS: A total of 45 studies were retrieved, including 7 randomized controlled trials...
July 12, 2017: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/28697143/pancreatic-cystic-lesions-a-challenging-entity-in-children
#6
Mariana Borges-Dias, Claudia Silva, Manuel Oliveira, José Estevão-Costa, Miguel Campos
No abstract text is available yet for this article.
August 2017: Pancreas
https://www.readbyqxmd.com/read/28693851/a-population-based-analysis-of-a-rare-oncologic-entity-malignant-pancreatic-tumors-in-children
#7
Konstantinos S Mylonas, Dimitrios Nasioudis, Diamantis I Tsilimigras, Ilias P Doulamis, Peter T Masiakos, Cassandra M Kelleher
PURPOSE: To examine the clinicopathological characteristics and prognosis of pediatric patients with malignant pancreatic tumors in a population-based cohort. METHODS: The Surveillance, Epidemiology, and End Results (SEER) database was utilized to identify all pediatric patients with malignant pancreatic tumors, diagnosed between 1973 and 2013. Kaplan-Meier analysis was performed to determine median and five-year overall survival (OS) rates. Univariate survival analysis was executed using the log-rank test...
June 30, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28693787/secretin-enhanced-magnetic-resonance-cholangiopancreatography-for-assessing-pancreatic-secretory-function-in-children
#8
Andrew T Trout, Daniel B Wallihan, Suraj Serai, Maisam Abu-El-Haija
OBJECTIVE: To assess the accuracy and interrater reproducibility of measurements of pancreatic secretory function by magnetic resonance cholangiopancreatography in response to secretin administration and to describe our experience using the technique to noninvasively assess pancreatic secretory function in a pediatric population. STUDY DESIGN: In the accuracy study, phantoms with varying fluid volume (47-206 mL) were imaged using the clinical quantification sequence...
July 7, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28691939/autoantibodies-against-glycoprotein-2-isoforms-in-pediatric-patients-with-inflammatory-bowel-disease
#9
Nadja Röber, Lydia Noß, Alexander Goihl, Dirk Reinhold, Josefine Jahn, Jan de Laffolie, Wolf Johannes, Gunter M Flemming, Dirk Roggenbuck, Karsten Conrad, Martin W Laass
BACKGROUND: Anti-Glycoprotein 2 (GP2) antibodies are associated with a more complicated course of Crohn's disease (CD) in adults. Four different GP2 isoforms with different length and antibody-binding sites have been identified so far but not been explored in serological studies. We aimed to investigate the diagnostic utility of autoantibodies against all 4 isoforms of GP2 in an exclusively pediatric population for the first time. METHODS: We included 278 children and adolescents with inflammatory bowel disease: 164 with CD, 114 with ulcerative colitis, 83 disease controls (acute gastrointestinal infection, nonspecific gastrointestinal functional disorders), and 219 healthy controls...
July 6, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28690754/-pancreatic-pleural-fistula-in-children-a-rare-cause-of-great-abundant-pleurisy
#10
Aida Daib, Youssef Hellal, Malek Boughdir, Rabiaa Ben Abdallah, Nejib Kaabar
Pancreatic-pleural fistula is a very rare complication of false cysts of the pancreas. Our study aimed to describe this rare pathology affecting children. We emphasized the importance of evoking this diagnosis in the presence of great abundant pleurisy even in the absence of the digestive signs. We here report the case of a 2-year old child with false cyst of the pancreas complicated by pleural fistula detected after great abundant pleurisy with no digestive signs associated.
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28688652/optimal-timing-of-cholecystectomy-in-children-with-gallstone-pancreatitis
#11
Faidah Badru, Saurabh Saxena, Robert Breeden, Maximillan Bourdillon, Colleen Fitzpatrick, Kaveer Chatoorgoon, Jose Greenspon, Gustavo Villalona
BACKGROUND: Little data exist regarding the recurrence of pancreatitis in pediatric patients with gallstone pancreatitis awaiting cholecystectomy. This study evaluates the recurrence rate of pancreatitis after acute gallstone pancreatitis based on the timing of cholecystectomy in pediatric patients. MATERIALS AND METHODS: A retrospective chart review of all patients admitted with gallstone pancreatitis from 2007 to 2015 was performed. Children were divided into the following five groups...
July 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28682805/management-of-acute-pancreatitis-in-children
#12
Maisam Abu-El-Haija, Tom K Lin, Jaimie D Nathan
PURPOSE OF REVIEW: Pediatric acute pancreatitis has been on the rise in the last decades, with an incidence close to adult pancreatitis. In the majority of cases acute pancreatitis resolves spontaneously, but in a subset of children the disease progresses to severe acute pancreatitis with attendant morbidity and mortality. RECENT FINDINGS: Pediatric acute pancreatitis in this era is recognized as a separate entity from adult acute pancreatitis given that the causes and disease outcomes are different...
July 5, 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/28656511/hyperinsulinemic-hypoglycemia-clinical-molecular-and-therapeutical-novelties
#13
Arianna Maiorana, Carlo Dionisi-Vici
Hyperinsulinemic hypoglycemia (HI) is the most common cause of hypoglycemia in children. Impairment of cellular pathways involved in insulin secretion from pancreatic β-cells, broadly classified as channelopathies and metabolopathies, have been discovered in the past two decades. The increasing use of NGS target panels, combined with clinical, biochemical and imaging findings allows differentiating the diagnostic management of children with focal forms, surgically curable, from those with diffuse forms, more conservatively treated with pharmacological and nutritional interventions...
July 2017: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/28650396/therapeutic-endoscopic-retrograde-cholangiopancreatography-in-pediatric-patients-with-acute-recurrent-and-chronic-pancreatitis-data-from-the-insppire-international-study-group-of-pediatric-pancreatitis-in-search-for-a-cure-study
#14
David M Troendle, Douglas S Fishman, Bradley A Barth, Matthew J Giefer, Tom K Lin, Quin Y Liu, Maisam Abu-El-Haija, Melena D Bellin, Peter R Durie, Steven D Freedman, Cheryl Gariepy, Tanja Gonska, Melvin B Heyman, Ryan Himes, Sohail Z Husain, Soma Kumar, Mark E Lowe, Veronique D Morinville, Chee Y Ooi, Joseph Palermo, John F Pohl, Sarah Jane Schwarzenberg, Steven Werlin, Michael Wilschanski, M Bridget Zimmerman, Aliye Uc
OBJECTIVE: The aim of this study was to characterize utilization and benefit of therapeutic endoscopic retrograde cholangiopancreatography (ERCP) in children with acute recurrent pancreatitis (ARP) or chronic pancreatitis (CP). METHODS: From August 2012 to February 2015, 301 children with ARP or CP were enrolled in the INSPPIRE (INternational Study group of Pediatric Pancreatitis: In search for a cuRE) study. Physicians reported utilization and benefit of therapeutic ERCP at enrollment...
June 22, 2017: Pancreas
https://www.readbyqxmd.com/read/28648269/genetic-predisposition-to-acute-recurrent-and-chronic-pancreatitis-more-evidence-for-a-role-in-children
#15
Christopher Duggan
No abstract text is available yet for this article.
July 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28639921/multisystem-imaging-findings-of-cystic-fibrosis-in-adults-recognizing-typical-and-atypical-patterns-of-disease
#16
Sarah Averill, Meghan G Lubner, Christine O Menias, Sanjeev Bhalla, Vincent M Mellnick, Tabassum A Kennedy, Perry J Pickhardt
OBJECTIVE: There is an expanding and increasingly heterogeneous population of adult patients with cystic fibrosis (CF). Although CF is usually diagnosed in children with progressive multisystem involvement, up to 7% of CF cases are currently diagnosed de novo in adults with subtle manifestations distinct from the typical features of classic CF. The purpose of this article is to present the wide spectrum of CF in adults, including both classic and nonclassic variants, with an emphasis on the nonclassic imaging findings...
July 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28639336/classification-of-pancreaticobiliary-maljunction-and-clinical-features-in-children
#17
Naoto Urushihara, Yoshinori Hamada, Terumi Kamisawa, Hideki Fujii, Tsugumichi Koshinaga, Yoshiki Morotomi, Takeshi Saito, Takao Itoi, Kenitiro Kaneko, Hiroaki Fukuzawa, Hisami Ando
PURPOSE: In 2015, the Committee on Diagnostic Criteria of the Japanese Study Group on Pancreaticobiliary Maljunction (PBM) proposed a classification of PBM into four types: (A) stenotic type, (B) non-stenotic type, (C) dilated channel type, and (D) complex type. To validate this classification and clarify the clinical features of the four types of PBM, a retrospective multicenter study was conducted. METHODS: We divided the study group of 317 children with PBM into the four types of PBM...
June 21, 2017: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/28627192/-excess-weight-in-patients-with-cystic-fibrosis-is-it-always-beneficial
#18
David González Jiménez, Rosana Muñoz-Codoceo, María Garriga-García, Manuel Molina-Arias, Marina Álvarez-Beltrán, Ruth García-Romero, Cecilia Martínez-Costa, Silvia María Meavilla-Olivas, Luis Rodrigo Peña-Quintana, Silvia Gallego Gutiérrez, José Manuel Marugán de Miguelsanz, Lucrecia Suárez Cortina, Esperanza Natividad Castejón Ponce, Rosaura Leis Trabazo, Fayna Martín Cruz, Juan José Díaz Martín, Carlos Bousoño García
INTRODUCTION: The primary objective of this study was to find out the prevalence of overweight and obese status, as well as their association to pulmonary function, total cholesterol and vitamin D in patients with cystic fibrosis (CF). MATERIALS AND METHODS: This is a multicenter descriptive and cross-sectional study. Twelve Spanish hospitals participated. 451 patients with CF were included. Adults were classified according to body mass index (BMI) and children were classified according to BMI percentiles (WHO tables)...
June 5, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28616918/-value-of-procalcitonin-high-sensitivity-c-reactive-protein-and-pancreatic-stone-protein-in-predicting-prognosis-of-children-with-sepsis
#19
Jun-Ming Huo, Rui Huo, Ling Hu, Si-Wei Lu, Jian Zu
OBJECTIVES: To determine the value of procalcitonin (PCT), high sensitivity C-reactive protein (hs-CRP) and pancreatic stone protein(PSP) in predicting the prognosis of children with sepsis. METHODS: A total of 106 hospitalized children [(4.4±1.6) year-old] with sepsis were enrolled in this study. The expressions of PTC, hs-CRP and PSP in the serum samples of the children were detected on the first day of admission to hospital. Pearson correlation analyses were performed to test the correlations between pediatric critical illness score (PCIS) and PTC, hs-CRP and PSP...
May 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28609364/therapeutic-endoscopic-retrograde-cholangiopancreatography-in-pediatric-patients-with-acute-recurrent-and-chronic-pancreatitis-data-from-the-insppire-international-study-group-of-pediatric-pancreatitis-in-search-for-a-cure-study
#20
David M Troendle, Douglas S Fishman, Bradley A Barth, Matthew J Giefer, Tom K Lin, Quin Y Liu, Maisam Abu-El-Haija, Melena D Bellin, Peter R Durie, Steven D Freedman, Cheryl Gariepy, Tanja Gonska, Melvin B Heyman, Ryan Himes, Sohail Z Husain, Soma Kumar, Mark E Lowe, Veronique D Morinville, Chee Y Ooi, Joseph Palermo, John F Pohl, Sarah Jane Schwarzenberg, Steven Werlin, Michael Wilschanski, M Bridget Zimmerman, Aliye Uc
OBJECTIVE: The aim of this study was to characterize utilization and benefit of therapeutic endoscopic retrograde cholangiopancreatography (ERCP) in children with acute recurrent pancreatitis (ARP) or chronic pancreatitis (CP). METHODS: From August 2012 to February 2015, 301 children with ARP or CP were enrolled in the INSPPIRE (INternational Study group of Pediatric Pancreatitis: In search for a cuRE) study. Physicians reported utilization and benefit of therapeutic ERCP at enrollment...
July 2017: Pancreas
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