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https://www.readbyqxmd.com/read/28737827/cytotoxic-and-chemosensitization-effects-of-scutellarin-from-traditional-chinese-herb-scutellaria%C3%A2-altissima%C3%A2-l-in-human-prostate-cancer-cells
#1
Chen Gao, Yinglu Zhou, Zhongling Jiang, Yuan Zhao, Dongjun Zhang, Xia Cong, Rongfeng Cao, Huatao Li, Wenru Tian
Scutellaria altissima L. is a common traditional Chinese medicine used to treat inflammation in some countries. Scutellarin, an active major flavone glycoside isolated from the traditional Chinese medicine Scutellaria altissima L., has been shown to offer various beneficial biochemical effects on cerebrovascular diseases and inflammation. However, the antiproliferative effects of Scutellarin in prostate cancer and the underlying mechanism are not fully elucidated. In the present study, we aimed to ascertain whether Scutellarin inhibits cancer cell growth and to further explore the molecular mechanism...
July 24, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28737825/combination-of-rapamycin-and-garlic-derived-s-allylmercaptocysteine-induces-colon-cancer-cell-apoptosis-and-suppresses-tumor-growth-in-xenograft-nude-mice-through-autophagy-p62-nrf2-pathway
#2
Siying Li, Guang Yang, Xiaosong Zhu, Lin Cheng, Yueyue Sun, Zhongxi Zhao
The natural plant-derived product S-allylmercapto-cysteine (SAMC) has been studied in cancer therapy as a single and combination chemotherapeutic agent. The present study was employed to verify the combination use of SAMC and rapamycin that is the mTOR inhibitor with anticancer ability but has limited efficacy due to drug resistance, and to explore the underlying mechanisms. We combined rapamycin and SAMC for colorectal cancer treatment in the HCT‑116 cancer cells and a xenograft murine model. The in vivo study was established by xenografting HCT‑116 cells in BALB/c nude mice...
July 24, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28731184/bufalin-reverses-acquired-drug-resistance-by-inhibiting-stemness-in-colorectal-cancer-cells
#3
Jian Sun, Ke Xu, Yanyan Qiu, Hong Gao, Jianhua Xu, Qingfeng Tang, Peihao Yin
Drug resistance is an obstacle to chemotherapy in tumor patients. Recent studies have shown that the high stemness of cancer cells may be induced by chemotherapeutic drugs, which is correlated with drug resistance. In the present study, we investigated the effects of bufalin on the stemness of colorectal cancer. We found that cisplatin could induce high stemness through the tumorsphere formation assay in vitro and in vivo in the colorectal cancer cell lines HCT116 and LoVo. In addition, cisplatin-treated tumorsphere cells showed drug‑resistant properties...
July 17, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28725220/a-novel-derivative-of-mycousnine-produced-by-the-endophytic-fungus-mycosphaerella-nawae-exhibits-high-and-selective-immunosuppressive-activity-on-t-cells
#4
Li-Wei Wang, Jin-Liang Wang, Jing Chen, Jia-Jie Chen, Jia-Wei Shen, Xiao-Xiao Feng, Christian P Kubicek, Fu-Cheng Lin, Chu-Long Zhang, Feng-Yang Chen
An endophytic fungus, Mycosphaerella nawae ZJLQ129, was isolated from the leaves of the traditional Chinese medicine Smilax china. From the fermentation broth and mycelium, a dibenzofurane compound (-)mycousnine (1) was isolated. Chemical modification of it to the amide derivative (-)mycousnine enamine (2), which is new to science, was found to have high and selective immunosuppressive activity: similar to cyclosporin A, (-)mycousnine enamine (2) selectively inhibited T cell proliferation, suppressed the expression of the surface activation antigens CD25 and CD69 and the formation and expression of the cytokines interleukin-2 as well as interferon γ in activated T cells, but did not show any effect on the proliferation of B cells and cancer cells (PANC-1 and A549) and the activation of macrophages...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28722095/-correlation-of-mri-apparent-diffusion-coeffcient-with-molecular-marker-ki-67-in-gastric-cancer
#5
Guodian Zheng, Xiangdong Cheng, Lijing Wang, Zhiyuan Xu, Xuning Gao, Pengfei Yu, Hang Lyu, Ting Huang, Jiahui Chen
OBJECTIVES: To study the correlation between MRI apparent diffusion coefficient (ADC) and expression of Ki-67 in gastric cancers, and to investigate the application of ADC value in diagnosing the malignance of gastric cancer. METHODS: A retrospective cohort analysis was performed on 87 gastric cancer patients who received MRI examination and radical resection at Zhejiang Provincial Hospital of Traditional Chinese Medicine from November 2014 to August 2015. All the postoperative resected samples were confirmed as gastric cancer...
July 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28720093/solanum-nigrum-unripe-fruit-fraction-attenuates-adriamycin-resistance-by-down-regulating-multi-drug-resistance-protein-mdr-1-through-jak-stat-pathway
#6
Sankar Jagadeeshan, Diana David, S Jisha, S Manjula, S Asha Nair
BACKGROUND: Solanum nigrum, herbal plant that commonly grows in temperate climate zone, has been used as a traditional folk medicine whose ripen fruits were proven to exhibit anti-tumor properties. In traditional Chinese medicine, it has been used for centuries to cure inflammation, edema, mastitis and hepatic cancer and in the Ayurvedic system of traditional medicine in India, S. nigrum is applied against enteric diseases, ulcer, diarrhea and skin diseases. A methanolic glycosidic extract fraction of unripe fruit of S...
July 18, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28713966/spica-prunellae-extract-suppresses-the-growth-of-human-colon-carcinoma-cells-by-targeting-multiple-oncogenes-via-activating-mir-34a
#7
Yi Fang, Ling Zhang, Jianyu Feng, Wei Lin, Qiaoyan Cai, Jun Peng
Spica Prunellae is the spike of the herb Prunella vulgaris L. in traditional Chinese medicine which is often used for the treatment of various cancers including colorectal cancer. In the present study, we found that a key tumor suppressor, microRNA-34a (miR-34a) is involved in the antitumor activity for Spica Prunellae. Human colon carcinoma HCT-8 cells treated with an ethanol extract of Spica Prunellae (EESP) had significantly decreased cell proliferation and viability, in a dose-dependent manner. Flow cytometry analysis with Annexin V/PI staining analysis revealed that EESP treatment could induce apoptosis of HCT-8 cells...
July 6, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28702078/anticancer-activities-and-mechanisms-of-heat-clearing-and-detoxicating-traditional-chinese-herbal-medicine
#8
REVIEW
Yulin Zhang, Yeer Liang, Chengwei He
In traditional Chinese medicine (TCM) theory, pathogenic heat and toxins, which are akin to the inflammatory factors, are the causes of cancer and could promote its virulent development. Therefore, heat-clearing and detoxicating (HCD) herbs are essential components of TCM formulas for cancer treatment. An increasing interest has been focused on the study of HCD herbs and accumulated evidences have shown that HCD herbs or HCD herbs-based formulas exhibited remarkable anticancer effects when used alone or combined with other therapeutic approaches...
2017: Chinese Medicine
https://www.readbyqxmd.com/read/28701952/a-systematic-review-of-the-immune-regulating-and-anticancer-activities-of-pseudolaric-acid-b
#9
REVIEW
Mei-Lun Liu, Dan Sun, Tan Li, Hong Chen
Cortex pseudolaricis, the root bark of Pseudolarix kaempferi Gord, has been used to treat tinea and other skin diseases for the antimicrobial activities in Traditional Chinese Medicine (TCM). Pseudolaric acid B (PAB) has been identified as the major component responsible for the action of C. pseudolaricis. Recently, PAB has been demonstrated to be used as novel treatments for cancer, immune disorders, inflammatory diseases, and immunosuppression. However, the mechanisms through which PAB exerts its properties are not understood well, and little attention in the literature has been given to review its pharmacological activities before...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28698525/hepatoprotective-role-of-hydrangea-macrophylla-against-sodium-arsenite-induced-mitochondrial-dependent-oxidative-stress-via-the-inhibition-of-mapk-caspase-3-pathways
#10
Md Rashedunnabi Akanda, Hyun-Jin Tae, In-Shik Kim, Dongchoon Ahn, Weishun Tian, Anowarul Islam, Hyeon-Hwa Nam, Byung-Kil Choo, Byung-Yong Park
Sodium arsenite (NaAsO₂) has been recognized as a worldwide health concern. Hydrangea macrophylla (HM) is used as traditional Chinese medicine possessing antioxidant activities. The study was performed to investigate the therapeutic role and underlying molecular mechanism of HM on NaAsO₂-induced toxicity in human liver cancer (HepG2) cells and liver in mice. The hepatoprotective role of HM in HepG2 cells was assessed by using 3-(4,5-dimethylthiazol-2-Yl)-2,5-diphenyltetrazolium bromide (MTT), reactive oxygen species (ROS), and lactate dehydrogenase (LDH) assays...
July 10, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28698154/panax-ginseng-and-panax-quinquefolius-from-pharmacology-to-toxicology
#11
REVIEW
Cesare Mancuso, Rosaria Santangelo
The use of Panax ginseng and Panax quinquefolius in traditional Chinese medicine dates back to about 5000 years ago thanks to its several beneficial and healing properties. Over the past few years, extensive preclinical and clinical evidence in the scientific literature worldwide has supported the beneficial effects of P. ginseng and P. quinquefolius in significant central nervous system, metabolic, infectious and neoplastic diseases. There has been growing research on ginseng because of its favorable pharmacokinetics, including the intestinal biotransformation which is responsible for the processing of ginsenosides - contained in the roots or extracts of ginseng - into metabolites with high pharmacological activity and how such principles act on numerous cell targets...
July 8, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28693270/hyperthermia-and-radiation-reduce-the-toxic-side-effects-of-bufadienolides-for-cancer-therapy
#12
Heba Emam, Alaa Refaat, Paras Jawaid, Mati Ur Rehman, Peng Li, Qing-Li Zhao, Takashi Kondo
Bufadienolides are constituents of the traditional Chinese medicine Chan Su and are found in toad venom. Cardiovascular side-effects are one of the limiting factors towards developing bufadienolides as chemotherapeutic agents. Thus, in the present study, low doses of bufalin and cinobufotalin, prominent members of the bufadienolides, were investigated for their cytotoxic activity in combination with hyperthermia (HT) or radiation (Rad) therapy. In addition, the underlying mechanism involved was investigated...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28693146/inhibition-of-paclitaxel-resistance-and-apoptosis-induction-by-cucurbitacin-b-in-ovarian-carcinoma-cells
#13
Yingchun Qu, Peifang Cong, Chengjiang Lin, Yihui Deng, Jesse Li-Ling, Meixia Zhang
Ovarian cancer is the leading cause of mortality among all gynecological malignancies. Drug resistance is a cause of ovarian cancer recurrence and low rate of overall survival. There is a requirement for more effective treatment approaches. Cucurbitacin B (CuB) is an antineoplastic agent derived from traditional Chinese medicinal herbs. Its activity against paclitaxel-resistant human ovarian cancer cells has, however, not yet been established. The purpose of the present study was to investigate the effect and mechanism of CuB on human paclitaxel-resistant ovarian cancer A2780/Taxol cells...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28693129/identification-of-anti-tumor-components-from-toad-venom
#14
Fei Gao, Xiangjun Wang, Zhao Li, Aicun Zhou, Evelyn Tiffany-Castiglioni, Lijun Xie, Yongchang Qian
Secretion of granular glands from the skin of amphibians is a fascinating resource of active substances, particularly for cancer therapy in clinical practice of Traditional Chinese Medicine. A variety of anti-tumor peptides have been isolated from different toads and frogs; however, no anti-tumor peptides are reported in toad venom of Bufo gargarizans. Firstly, soluble fraction from fresh toad venom (FTV) was compared with that from dried toad venom (DTV), using HPLC analysis. It was revealed that FTV has a different HPLC chromatography compared with DTV...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28692435/prim-o-glucosylcimifugin-induces-cell-cycle-arrest-and-apoptosis-in-acute-lymphoblastic-leukemia-cells
#15
Lu Zhang, Xiaodi Liu, Xiongbin Lu, Cheng Huang
Prim-O-glucosylcimifugin is a major constituent in Radix Saposhnikovia that has been long used for the treatment of pyrexia, rheumatism, and cancer in traditional Chinese medicine. However, the molecular and cellular mechanisms remain unknown regarding the therapeutic effect of prim-O-lucosylcimifugin. Here, we investigated the effects of prim-O-glucosylcimifugin on cell cycle progression and apoptosis in human acute lymphoblastic leukemia cells. Prim-O-glucosylcimifugin treatment resulted in marked increases in cell apoptosis and cell cycle arrest at the G2/M phase...
July 7, 2017: Anti-cancer Drugs
https://www.readbyqxmd.com/read/28688953/antrodia-camphorata-inhibits-metastasis-and-epithelial-to-mesenchymal-transition-via-the-modulation-of-claudin-1-and-wnt-%C3%AE-catenin-signaling-pathways-in-human-colon-cancer-cells
#16
You-Cheng Hseu, Yu-Hsien Chao, Kai-Yuan Lin, Tzong-Der Way, Hui-Yi Lin, Varadharajan Thiyagarajan, Hsin-Ling Yang
ETHNOPHARMACOLOGICAL RELEVANCE: Antrodia camphorata (AC) is a well known traditional Chinese medicinal mushroom in Taiwan, has been used to treat various diseases including cancer. MATERIALS AND METHODS: In this study, we investigated the anti-metastatic and anti-EMT properties of a fermented culture broth of AC in human colon SW480(claudin-1-) and metastatic SW620(claudin-1+) cancer cells in vitro. RESULTS: AC down-regulates claudin-1 and inhibits the proliferation and colony-formation abilities of both SW620(claudin-1+) and SW480(claudin-1-) cells...
July 5, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28684297/curcumol-induces-cell-cycle-arrest-in-colon-cancer-cells-via-reactive-oxygen-species-and-akt-gsk3%C3%AE-cyclin-d1-pathway
#17
Juan Wang, Xu-Mei Li, Zhun Bai, Bi-Xia Chi, Yan Wei, Xu Chen
ETHNOPHARMACOLOGICAL RELEVANCE: Curcuma kwangsiensis S. G. Lee & C. F. Liang (Guangxi ezhu, in Chinese) belongs to the Zingiberaceae family, has been used as a traditionally Chinese medicine nearly 2,000 year. Curcumol is one of the guaiane-type sesquiterpenoid hemiketal isolated from medicine plant Curcuma kwangsiensis S. G. Lee & C. F. Liang, which has been reported possesses anti-cancer effects. Our previous study found that the most contribution to inhibit nasopharyngeal carcinoma cell growth was curcumol...
July 3, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28684164/neem-leaf-glycoprotein-generates-superior-tumor-specific-central-memory-cd8-t-cells-than-cyclophosphamide-that-averts-post-surgery-solid-sarcoma-recurrence
#18
Sarbari Ghosh, Madhurima Sarkar, Tithi Ghosh, Ipsita Guha, Avishek Bhuniya, Akata Saha, Shayani Dasgupta, Subhasis Barik, Anamika Bose, Rathindranath Baral
The success of cancer vaccines is limited as most of them induce corrupted CD8(+) T cell memory populations. We reported earlier that a natural immunomodulator, neem leaf glycoprotein (NLGP), therapeutically restricts tumor growth in a CD8(+) T cell-dependent manner. Here, our objective is to study whether memory CD8(+) T cell population is generated in sarcoma hosts after therapeutic NLGP treatment and their role in prevention of post-surgery tumor recurrence, in comparison to the immunostimulatory metronomic cyclophosphamide (CTX) treatment...
July 3, 2017: Vaccine
https://www.readbyqxmd.com/read/28678918/cantharidin-suppressed-breast-cancer-mda-mb-231-cell-growth-and-migration-by-inhibiting-mapk-signaling-pathway
#19
X-D Gu, L-L Xu, H Zhao, J-Z Gu, X-H Xie
As an active constituent of the beetle Mylabris used in traditional Chinese medicine, cantharidin is a potent and selective inhibitor of protein phosphatase 2A (PP2A) that plays a crucial role in cell cycle progression, apoptosis, and cell fate. The role and possible mechanisms exerted by cantharidin in cell growth and metastasis of breast cancer were investigated in this study. Cantharidin was found to inhibit cell viability and clonogenic potential in a time- and dose-dependent manner. Cell cycle analysis revealed that cell percentage in G2/M phase decreased, whereas cells in S and G1 phases progressively accumulated with the increasing doses of cantharidin treatment...
July 3, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28678759/danshen-improves-survival-of-patients-with-advanced-lung-cancer-and-targeting-the-relationship-between-macrophages-and-lung-cancer-cells
#20
Ching-Yuan Wu, Jong-Yuh Cherng, Yao-Hsu Yang, Chun-Liang Lin, Feng-Che Kuan, Yin-Yin Lin, Yu-Shih Lin, Li-Hsin Shu, Yu-Ching Cheng, Hung Te Liu, Ming-Chu Lu, Jthau Lung, Pau-Chung Chen, Hui Kuan Lin, Kuan-Der Lee, Ying-Huang Tsai
In traditional Chinese medicine, Salvia miltiorrhiza Bunge (danshen) is widely used in the treatment of numerous cancers. However, its clinical effort and mechanism in the treatment of advanced lung cancer are unclear. In our study, the in vivo protective effort of danshen in patients with advanced lung cancer were validated using data from the National Health Insurance Research Database in Taiwan. We observed in vitro that dihydroisotanshinone I (DT), a bioactive compound in danshen, exerts anticancer effects through many pathways...
June 28, 2017: Oncotarget
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