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https://www.readbyqxmd.com/read/28635648/deoxyelephantopin-and-isodeoxyelephantopin-as-potential-anticancer-agents-with-effects-on-multiple-signaling-pathways
#1
REVIEW
Tahir Mehmood, Amara Maryam, Hamed A Ghramh, Muhammad Khan, Tonghui Ma
Cancer is the 2nd leading cause of death worldwide. The development of drugs to target only one specific signaling pathway has limited therapeutic success. Developing chemotherapeutics to target multiple signaling pathways has emerged as a new prototype for cancer treatment. Deoxyelephantopin (DET) and isodeoxyelephantopin (IDET) are sesquiterpene lactone components of "Elephantopus scaber and Elephantopus carolinianus", traditional Chinese medicinal herbs that have long been used as folk medicines to treat liver diseases, diabetes, diuresis, bronchitis, fever, diarrhea, dysentery, cancer, and inflammation...
June 21, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28634392/the-traditional-chinese-medicine-achyranthes-bidentata-and-our-de-novo-conception-of-its-metastatic-chemoprevention-from-phytochemistry-to-pharmacology
#2
Zhou Jiang, Jun Qian, Haiyan Dong, Jingyi Yang, Xiaobo Yu, Jianzhong Chen, Hongning Chen, Qing Shi, Lee Jia
Our recent biosystems analysis revealed similarities between embryonic implantation and cancer cell adhesion, which suggests that abortifacients may be good for safe and effective metastatic chemoprevention targeting circulating tumor cells (CTC). Here we test the hypothesis by using the well-known abortion herb Achyranthes bidentata Blume (A. bidentata). Five compounds were separated from the herb root. Among them, ginsenoside Ro was the most potent in inhibiting embryonic implantation within non-cytotoxic concentrations...
June 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28627460/polysaccharides-from-epimedium-koreanum-nakai-with-immunomodulatory-activity-and-inhibitory-effect-on-tumor-growth-in-llc-bearing-mice
#3
Chengcheng Wang, Liang Feng, Jiayan Su, Li Cui, Dan Liu, Jun Yan, Chuanlin Ding, Xiaobin Tan, Xiaobin Jia
ETHNOPHARMACOLOGICAL RELEVANCE: Epimedium koreanum Nakai is documented as tonic herbal in China for over a thousand years and has the potential to enhance the body's immunity according to the theory of traditional Chinese medicine. Polysaccharides are one of the most important effective compounds in Epimedium koreanum Nakai. Accumulating evidence indicated polysaccharides derived from traditional Chinese medicine have potent immune-enhancing properties and relatively nontoxic effects in cancer treatment...
June 13, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28624793/bufalin-reverses-abcb1-mediated-drug-resistance-in-colorectal-cancer
#4
Ze-Ting Yuan, Xiao-Jing Shi, Yu-Xia Yuan, Yan-Yan Qiu, Yu Zou, Cheng Liu, Hui Yu, Xue He, Ke Xu, Pei-Hao Yin
Multidrug resistance (MDR), mainly mediated by ABCB1 transporter, is a major cause for chemotherapy failure. Bufalin (BU), an active component of the traditional Chinese medicine chan'su, has been reported to have antitumor effects on various types of cancer cells. The purpose of this present study was to investigate the reversal effect of BU on ABCB1-mediated multidrug resistance in colorectal cancer. BU at safe concentration (5, 10, 20 nM) could reverse chemosensitivity of ABCB1-overexpression HCT8/ADR, LoVo/ADR and HCT8/ABCB1 nearly back to their parental cells level...
May 26, 2017: Oncotarget
https://www.readbyqxmd.com/read/28619365/aucklandia-lappa-dc-extract-enhances-gefitinib-efficacy-in-gefitinib-resistance-secondary-epidermal-growth-factor-receptor-mutations
#5
Guan Huang, Yanli Tong, Qidi He, Jie Wang, Zuanguang Chen
ETHNOPHARMACOLOGICAL RELEVANCE: Aucklandia lappa DC. is a widely used medicinal plant in China, India and Pakistan for a long time. Previously, a number of different pharmacological experiments in vitro and in vivo have convincingly demonstrated the abilities of it to exhibit anticancer activities. Reynoutria japonica Houtt. has also been widely used as traditional Chinese medicinal plant. Previous studies have demonstrated that it is bioactive to exhibit anticancer activities. AIM OF THE STUDY: This study aims to investigate whether the extracts of Aucklandia lappa DC...
June 12, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28619304/the-prevalence-rate-of-deviations-in-body-constitutions-and-related-factors-in-follow-up-stage-breast-cancer-patients-a-nationwide-study
#6
Shu-Chuan Amy Lin, Pei-Yi Chu, Li-Li Chen, Yi-Chang Su, Shin-Mae Wang
OBJECTIVES: The aim of this study was to apply a rigorous traditional Chinese medicine (TCM) body constitution questionnaire (BCQ) to survey the prevalence rate of deviations in body constitution and to explore the health-related lifestyle behavior factors of deviations in body constitution. DESIGN: A cross-sectional study was administered through postal mail. Subjects were recruited from a national organization for breast cancer patients (Taiwan Breast Cancer Alliance)...
June 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/28608834/multi-dimensional-spectrum-effect-relationship-of-the-impact-of-chinese-herbal-formula-lichong-shengsui-yin-on-ovarian-cancer
#7
Yanhong Wang, Yang Li, Yan Zhang, Guan Feng, Zhixin Yang, Qingxia Guan, Rui Wang, Fengjuan Han
Lichong Shengsui Yin (LCSSY) is an effective and classic compound prescription of Traditional Chinese Medicines (TCMs) used for the treatment of ovarian cancer. To investigate its pharmacodynamic basis for treating ovarian cancer, the multi-dimensional spectrum-effect relationship was determined. Four compositions (I to IV) were obtained by extracting LCSSY successively with supercritical CO₂ fluid extraction, 75% ethanol reflux extraction, and the water extraction-ethanol precipitation method. Nine samples for pharmacological evaluation and fingerprint analysis were prepared by changing the content of the four compositions...
June 13, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28608578/cantharidin-inhibits-competitively-heme-fe-iii-binding-to-the-fa1-site-of-human-serum-albumin
#8
Fabio Polticelli, Loris Leboffe, Valentina Tortosa, Viviana Trezza, Gabriella Fanali, Mauro Fasano, Paolo Ascenzi
Cantharidin, a monoterpene isolated from the insect blister beetle, has long been used as a medicinal agent in the traditional Chinese medicine. Cantharidin inhibits a subgroup of serine/threonine phosphatases, thus inducing cell growth inhibition and cytotoxicity. Cantharidin has anticancer activity in vitro, since it is able of inducing p53-dependent apoptosis and double-strand breakage of DNA in cancer cells. Although the toxicity of cantharidin to the gastrointestinal and urinary tracts prevents its medical use, it is a promising lead compound for chemical modification to develop new anticancer therapeutics...
June 13, 2017: Journal of Molecular Recognition: JMR
https://www.readbyqxmd.com/read/28602865/anti-angiogenic-activity-of-water-extract-from-euphorbia-pekinensis-rupr
#9
Wenting Zhang, Bin Liu, Yaru Feng, Jie Liu, Zhiqiang Ma, Jian Zheng, Qing Xia, Yuanyuan Ni, Farong Li, Ruichao Lin
ETHNOPHARMACOLOGICAL RELEVANCE: Euphorbia pekinensis Rupr. (EP) is a Euphorbia species of Euphorbiaceae, which is widely used in traditional Chinese medicine. It has been reported to exhibit therapeutic effects on solid tumors, leukemias, and malignant ascites although underlying molecular mechanisms are poorly delineated. Anti-angiogenic therapy is a recognized strategy for treating cancer-based solid tumors, and is also associated with malignant ascites treatment. STUDY AIM: To study the anti-angiogenic properties of the water extract of EP vinegar preparation (WEVEP)...
June 7, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28599493/blueberries-inhibit-cyclooxygenase-1-and-cyclooxygenase-2-activity-in-human-epithelial-ovarian-cancer
#10
Wumei Lin, Zhigang Li
Ovarian cancer (OC) is the sixth and eighth leading cause of cancer mortality among women in developed and developing countries, respectively. Medical therapy is the main method for the treatment of OC. However, drug toxicity and the marked side effects of chemotherapy limit the usage and therapeutic results of the treatments. Therefore, the identification of multi-target agents with few side effects and high effectiveness is required. Traditional Chinese medicine has been used clinically to treat various types of cancer for thousands of years and is considered to possess multiple components and agents, which exert efficient therapeutic functions with few side effects...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28595013/fibroblast-activation-protein-alpha-activated-tripeptide-bufadienolide-anti-tumor-prodrug-with-reduced-cardiotoxicity
#11
Li-Juan Deng, Long-Hai Wang, Cheng-Kang Peng, Yi-Bin Li, Mao-Hua Huang, Min-Feng Chen, Xue-Ping Lei, Ming Qi, Yun Cen, Wen-Cai Ye, Dong-Mei Zhang, Wei-Min Chen
Bufadienolides are the major pharmacologic constituents of traditional Chinese medicine Chan'su, which are frequently used clinically for cancer treatment in China. Motivated by reducing or avoiding the cardiac toxicity of bufadienolides, we have designed, synthesized and evaluated the fibroblast activation protein alpha (FAPα)-activated tripeptide arenobufagin prodrugs with the purpose of improving the safety of arenobufagin (a representative bufadienolide). Among these FAPα-activated prodrugs, 3f exhibited the best hydrolytic efficiency by recombinant human FAPα (rhFAPα), and are selectively activated in tumors...
June 8, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28588727/synergistic-cytotoxic-effects-of-a-combined-treatment-of-a-pinellia-pedatisecta-lipid-soluble-extract-and-cisplatin-on-human-cervical-carcinoma-in-vivo
#12
Mingxing Zhang, Yi Yu, Hongwei Zhang, Haixia Huang, Qingqing Cai, Yu Kang, Guiling Li, Congjian Xu
Herbal medicines are known to have numerous benefits, including lower toxicity and fewer side effects than traditional chemotherapeutic drugs. In traditional Chinese medicine, the rhizome of Pinellia pedatisecta (PE) Schott has long been used to treat cancer, undiagnosed swelling and erythema toxicum. However, its medical benefits lack support from scientific evidence. A novel lipid-soluble extract from PE has been previously verified to enhance the cytotoxicity of cis-dichlorodiammineplatinum-II (CDDP) against human cervical cancer cells in vitro...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28588693/effect-of-traditional-chinese-medicine-components-on-multidrug-resistance-in-tumors-mediated-by-p-glycoprotein
#13
Xi Xia, Susan P C Cole, Tiange Cai, Yu Cai
Multidrug resistance (MDR) is a major cause of chemotherapy failure. It occurs when an organism is resistant to one type of drug, but also develops resistance to other drugs with different structures and targets. There is a high incidence of MDR in cancer chemotherapy, therefore, finding an effective and non-toxic MDR reversal agent is an important goal, particularly for P-glycoprotein-mediated MDR in cancer. Improvements continue to be made to the status and understanding of traditional Chinese medicine (TCM), due to the advantages of low toxicity and relatively minor side effects...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28588641/the-significant-pathways-and-genes-underlying-the-colon-cancer-treatment-by-the-traditional-chinese-medicine-phy906
#14
Ziyuan Su, Changyu Zhou, Shaoyou Qin, Erna Jia, Zhenting Wu
BACKGROUND: We attempted to explore the molecular mechanism underlying PHY906 intervention of colon cancer. METHODS: The microarray data of tumors treated by PHY906 and PBS alone were downloaded from the public Gene Expression Omnibus database. The dataset was further analyzed for the differentially expressed genes (DEGs) and their related biological functions were analyzed, followed by function and pathways. Protein-protein interaction (PPI) network was constructed and the significant nodes were screened by network centralities and then the significant modules analysis...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28588481/medicinally-used-asarum-species-high-resolution-lc-ms-analysis-of-aristolochic-acid-analogs-and-in-vitro-toxicity-screening-in-hk-2-cells
#15
Johanna Michl, Olusheyi Bello, Geoffrey C Kite, Monique S J Simmonds, Michael Heinrich
Species of Asarum are used in traditional Chinese medicine and, similar to members of the genus Aristolochia, they contain aristolochic acid analogs (AAAs). These compounds are known for their nephrotoxic and carcinogenic effects. So far, the phytochemistry and nephrotoxicity of species of Asarum is not well studied. A high-resolution LC-MS-based metabolomic approach was used to study the phytochemical variation in medicinally used Asarum species. The cytotoxicity of the samples was assessed using human kidney (HK-2) cells...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28586759/traditional-chinese-medicine-ka-sai-ping-suppresses-the-growths-of-gastric-cancers-via-induction-of-autophagy
#16
Mo-Li Zhu, Jun-Xiu Lu, Guo-Pin Pan, Song Ping, Fan-Rong Zhao, Heng-Tian Qi, Hai-Ya Yu, Xu Jian, Guang-Rui Wan, Peng Li
Traditional Chinese medication is increasingly used to treat a wide range of human chronic diseases like cardiovascular diseases and cancers. This study was designed to explore whether ka-sai-ping (KSP), a novel traditional Chinese medicine developed by us, prevents gastric cancer growths and to investigate the underlying mechanism. The xenograft model of mouse gastric cancer was established by injecting MFCs into nude mouse subcutaneously. Cell autophagy was assessed by MDC staining. Lysosome and mitochondria were detected by Lyso-Tracker Red and Mito-Traker Green staining...
May 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28583393/separation-of-the-potential-g-quadruplex-ligands-from-the-butanol-extract-of-zanthoxylum-ailanthoides-sieb-zucc-by-countercurrent-chromatography-and-preparative-high-performance-liquid-chromatography
#17
Tian Han, Xueli Cao, Jing Xu, Hairun Pei, Hong Zhang, Yalin Tang
G-quadruplex DNA structure is considered to be a very attractive target for antitumor drug design due to its unique role in maintaining telomerase activities. Therefore, discovering ligands with high stability of G-quadruplex structure is of great interest. In this paper, pH-zone refining counter current chromatography (CCC) and preparative high performance liquid chromatography (HPLC) were employed for the separation of potent G-quadruplex ligands from the n-butanol fraction of the crude extract of Zanthoxylum ailanthoides, which is a traditional Chinese medicine recently found to display high inhibitory activity against several human cancer cells...
May 29, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28580556/-the-application-of-body-mind-spirit-integrated-psychotherapy-in-nursing-practice
#18
Fei-Hsiu Hsiao
Body-mind-spirit integrated psychotherapy reflects the core value of nursing by emphasizing the inseparable concept of body, mind, and spirit and caring for the holistic needs of the patient. Body-mind-spirit integrated psychotherapy was developed based on Western psychotherapy (positive psychology and forgiveness therapy), traditional Chinese medicine, and the Eastern philosophies of Buddhism, Taoism, and Confucianism. The present paper describes the holistic concepts that underpin this therapeutic approach...
June 2017: Hu Li za Zhi the Journal of Nursing
https://www.readbyqxmd.com/read/28569510/in-situ-electrodeposited-synthesis-of-electrochemiluminescent-ag-nanoclusters-as-signal-probe-for-ultrasensitive-detection-of-cyclin-d1-from-cancer-cells
#19
Ying Zhou, Maoxin Chen, Ying Zhuo, Yaqin Chai, Wenju Xu, Ruo Yuan
Metal nanoclusters (NCs) as a new type of electrochemiluminescence (ECL) nanomaterials have attracted great attention, but their applications are limited due to relatively low luminescent efficiency and a complex preparation process. Herein, an ultrasensitive ECL biosensor for the detection of Cyclin-D1 (CCND1) was designed by utilizing in situ electrogenerated silver nanoclusters (AgNCs) as ECL emitters and Fe3O4-CeO2 nanocomposites as a coreaction accelerator. The ECL luminous efficiency of AgNCs on the electrode could be significantly enhanced with the use of the Fe3O4-CeO2 for accelerating the reduction of S2O8(2-) to generate the strong oxidizing intermediate radical SO4(•-)...
June 9, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28565760/in-silico-insight-into-egfr-treatment-in-patients-with-lung-carcinoma-and-t790m-mutations
#20
Shu-Zhi Zang, Yan-Rong Yang, Sha-Sha Zhao, Yun-Xia Li, Xin-Yuan Gao, Chun-Lei Zhong
The T790M mutational basis of treatment failure, following treatment via alteration of the epidermal growth factor receptor (EGFR) pathway, is a well-known anomaly in patients with non-small cell lung cancer (NSCLC). The T790M mutation activates the kinase domain, causing tyrosine kinase inhibitors, such as gefitinib, to elicit little or no response. To overcome this acquired resistance in NSCLC cells, the present study utilized a structure-based drug designing method to identify a novel lead compound. An in-house traditional Chinese medicinal compound database was used and following initial virtual screening, pre-absorption, distribution, metabolism and excretion/Tox and automated docking analyses, nardosinon was selected as the most appropriate candidate for further analysis...
May 2017: Experimental and Therapeutic Medicine
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