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https://www.readbyqxmd.com/read/27912948/therapeutic-efficacy-of-traditional-chinese-medicine-kuan-sin-yin-in-patients-undergoing-chemotherapy-for-advanced-colon-cancer-a-controlled-trial
#1
Tsai-Ju Chien, Chia-Yu Liu, Ruey-Hwa Lu, Chin-Wei Kuo, Yang-Chao Lin, Chung-Hua Hsu
BACKGROUND: Traditional Chinese Medicine (TCM) has been used increasingly as complementary medicine in cancer care. Kuan-Sin-Yin (KSY) is a TCM decoction containing seven herbs known to cause immunomodulation or anticancer activity, and which are associated with the TCM concept of Qi and energy supply. Kuan-Sin-Yin has cytostatic effects on cancer cells in animal models. OBJECTIVE: The aim of this study is to evaluate the level of improvement in meridian energy and heart-rate variability (HRV) and to assess whether these observations are compatible with TCM theory...
December 2016: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/27912872/anti-allergic-potential-of-typhonium-blumei-inhibition-of-degranulation-via-suppression-of-pi3k-plc%C3%AE-2-phosphorylation-and-calcium-influx
#2
Michal Korinek, Kuan-Ming Chen, Yu-Han Jiang, Mohamed El-Shazly, Joel Stocker, Chon-Kit Chou, Tsong-Long Hwang, Yang-Chang Wu, Bing-Hung Chen, Fang-Rong Chang
BACKGROUND: Typhonium blumei Nicolson & Sivadasan (Araceae) is a traditional Chinese medicinal herb possessing detumescent, detoxifying, and anti-inflammatory activities. It is used in Taiwan as a folk medicine to treat cancer and inflammatory diseases. Typhonium blumei is usually not distinguished from Typhonium roxburghii Schott and they are commonly used interchangeably. PURPOSE: To evaluate and compare the anti-allergic and anti-inflammatory properties of T...
December 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/27900040/triptolide-exerts-pro-apoptotic-and-cell-cycle-arrest-activity-on-drug-resistant-human-lung-cancer-a549-taxol-cells-via-modulation-of-mapk-and-pi3k-akt-signaling-pathways
#3
Chen Qiong Xie, Ping Zhou, Jian Zuo, Xiang Li, Yong Chen, Jian Wei Chen
Multidrug resistance (MDR) is a major obstacle in the effective chemotherapeutic treatment of cancers. Triptolide (TPL) is a diterpenoid isolated from Tripterygium wilfordii Hook. f., a traditional Chinese medicine. It was demonstrated in our previous study that TPL exerts anti-MDR cancers on various MDR cell lines (including A549/Taxol, MCF-7/ADR and Bel7402/5-Fu). The present study was designed to investigate its anti-proliferative activity on A549/Taxol cells, and explore the underlying mechanism of action...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27897231/platycodin-d-potentiates-proliferation-inhibition-and-apoptosis-induction-upon-akt-inhibition-via-feedback-blockade-in-non-small-cell-lung-cancer-cells
#4
Ting Li, Xin Chen, Xiuping Chen, Dik Lung Ma, Chung Hang Leung, Jin Jian Lu
AKT is the frequently overexpressed and constitutively active kinase within NSCLC cells and recognized as a promising target for NSCLC treatment. However, AKT inhibition relieves the feedback inhibition of upstream receptor tyrosine kinases (RTKs) that may weaken the efficiency of AKT inhibitors. Platycodin D (PD), isolated from widely-used traditional Chinese medicine Platycodonis Radix, is now found to remarkably enhance the anti-proliferative effect of AKT inhibitors. In this study, combinatorial activity of AKT inhibitor MK2206 and PD on cell proliferation, apoptosis and related signaling were disclosed...
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27897164/hmgb1-mediated-autophagy-decreases-sensitivity-to-oxymatrine-in-sw982-human-synovial-sarcoma-cells
#5
Yongsong Cai, Peng Xu, Le Yang, Ke Xu, Jialin Zhu, Xiaoqing Wu, Congshan Jiang, Qiling Yuan, Bo Wang, Yuanbo Li, Yusheng Qiu
Oxymatrine (OMT) is a type of alkaloid extracted from a traditional Chinese medicinal herb, Sophora flavescens. Although the antitumor activities of OMT have been observed in various cancers, there are no reports regarding the effects of OMT on human synovial sarcoma. In the present study, we analyzed the antitumor activities of OMT in SW982 human synovial sarcoma cells and determine whether high mobility group box protein 1 (HMGB1)-mediated autophagy was associated with its therapeutic effects. We found that OMT exhibited antitumor activity in SW982 cells and facilitated increases in autophagy...
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27882217/multiple-effects-of-xihuang-pill-aqueous-extract-on-the-hs578t-triple-negative-breast-cancer-cell-line
#6
Wenxian Zheng, Shuyan Han, Shantong Jiang, Lina Pang, Xiaohong Li, Xijuan Liu, Minhua Cao, Pingping Li
The management of triple-negative breast cancer (TNBC) is challenging due to the aggressive behavior, lack of therapeutic options and relatively poor prognosis. Xihuang pill (XHP) is a well-known Traditional Chinese Medicine with anticancer activity. The aim of the present study was to investigate whether the aqueous extract of XHP (AEXHP) has anti-proliferative activity against the Hs578T TNBC cell line, and to elucidate its molecular mechanisms of action. First, an MTT assay was used to evaluate the anti-proliferative activity of AEXHP on the Hs578T cell line; furthermore, the cell cycle distribution, mitochondrial membrane potential and apoptotic rate were determined by flow cytometry, and western blot analysis was used to assess the expression of apoptosis and cell cycle regulatory proteins to investigate the mechanisms of action...
November 2016: Biomedical Reports
https://www.readbyqxmd.com/read/27882153/petroleum-ether-extract-of-chenopodium-album-l-prevents-cell-growth-and-induces-apoptosis-of-human-lung-cancer-cells
#7
Ting Zhao, Hui Pan, Yang Feng, Haizhou Li, Yang Zhao
Chenopodium album L. is a common edible herb distributed in China that has been used as a traditional Chinese medicine for antiviral, antifungal, anti-inflammatory and cancer treatment. However, to the best of our knowledge no previous reports have investigated its the function of its phytochemical extracts in lung cancer cells. The purpose of the present study was to assess the anticancer activities of the phytochemical extracts of C. album L. on human non-small cell lung cancer A549 cells. The present findings demonstrated that the petroleum ether (PE) extract of C...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27878294/arctigenin-a-lignan-from-arctium-lappa-l-inhibits-metastasis-of-human-breast-cancer-cells-through-the-downregulation-of-mmp-2-9-and-heparanase-in-mda-mb-231-cells
#8
Chenghua Lou, Zhihui Zhu, Yaping Zhao, Rui Zhu, Huajun Zhao
Arctigenin is a bioactive lignan isolated from the seeds of Arctium lappa L. which has been widely used as a diuretic and a diaphoretic in Traditional Chinese Medicine. In the present study, the authors investigated the effects of arctigenin on tumor migration and invasion in aggressive human breast cancer cells. The MTT assay results showed that arctigenin did not show a significant cytotoxic effect on the cell viability of MDA-MB-231 cells. However, wound healing migration and Boyden chamber invasion assays demonstrated that arctigenin significantly inhibited in vitro migration and invasion of the MDA-MB-231 cells...
November 23, 2016: Oncology Reports
https://www.readbyqxmd.com/read/27872653/the-zuo-jin-wan-formula-induces-mitochondrial-apoptosis-of-cisplatin-resistant-gastric-cancer-cells-via-cofilin-1
#9
Qing-Feng Tang, Jian Sun, Hui Yu, Xiao-Jing Shi, Rong Lv, Hong-Chang Wei, Pei-Hao Yin
Despite the status of cisplatin (DDP) as a classical chemotherapeutic agent in the treatment of cancer, the development of multidrug resistance often leads to a failure of DDP therapy. Here we found that phosphorylated cofilin-1 (p-cofilin-1) was overexpressed in the DDP-resistant human gastric cancer cell lines SGC7901/DDP and BGC823/DDP, relative to the respective parent cell lines (SGC7901 and BGC823), and that DDP induced the dephosphorylation of p-cofilin-1 in both parent lines but not in the DDP-resistant lines...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27863401/isoliquiritigenin-decreases-the-incidence-of-colitis-associated-colorectal-cancer-by-modulating-the-intestinal-microbiota
#10
Minna Wu, Yaqi Wu, Baoguo Deng, Jinsong Li, Haiying Cao, Yan Qu, Xinlai Qian, Genshen Zhong
Imbalances in intestinal bacteria correlate with colitis-associated colorectal cancer (CAC). Traditional Chinese medicines have been used to adjust the gut microbiota, and isoliquiritigenin (ISL), a flavonoid extracted from licorice, has shown antitumor efficacy. In this study, the effects of ISL on CAC development and the gut microbiota were evaluated using an azoxymethane and dextran sulphate sodium (AOM/DSS)-induced mouse model of CAC (CACM). Histopathological analysis suggested that ISL reduced tumor incidence in vivo...
November 15, 2016: Oncotarget
https://www.readbyqxmd.com/read/27847528/the-effectiveness-of-traditional-chinese-medicine-in-treating-patients-with-leukemia
#11
Yu-Jun Wang, Chung-Chih Liao, Hsuan-Ju Chen, Ching-Liang Hsieh, Tsai-Chung Li
Leukemia is the most common malignancy among all childhood cancers and is associated with a low survival rate in adult patients. Since 1995, the National Health Insurance (NHI) program in Taiwan has been offering insurance coverage for Traditional Chinese Medicine (TCM), along with conventional Western medicine (WM). This study analyzes the status of TCM utilization in Taiwan, in both pediatric and adult patients with leukemia. A retrospective cohort study was conducted using population-based National Health Insurance Research Database of Registry of Catastrophic Illness, involving patient data from 2001 to 2010 and follow-up data through 2011...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27843477/addition-and-subtraction-theory-of-tcm-using-xiao-chaihu-decoction-and-naturopathy-in-predicting-survival-outcomes-of-primary-liver-cancer-patients-a-prospective-cohort-study
#12
Min Dai, Yue-Wu Yang, Wen-Hai Guo, Feng-Lin Wang, Ge-Min Xiao, Yang-Mei Li, Hong-Zhi Yang
To investigate the therapeutic effect of combined Xiao-Chaihu-Decoction and naturopathic medicine therapy on survival outcomes of patients' PLC. In XCHD group (n = 76), patients were treated with Xiao-Chaihu-Decoction in accordance with the addition and subtraction theory of TCM; in NM group (n = 89), patients were managed by naturopathic medicine; in combined group (n = 70), the same volume of Xiao-Chaihu-Decoction combined with naturopathic medicine procedures was applied. There were no evident statistical differences of age, gender, KPS score, body weight, smoking status, AFP levels, HbsAg status, TBIL levels, tumor diameters, and numbers among different groups, showing comparability among groups...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27843296/evaluating-the-cytotoxic-effects-of-the-water-extracts-of-four-anticancer-herbs-against-human-malignant-melanoma-cells
#13
Binbing Ling, Deborah Michel, Meena Kishore Sakharkar, Jian Yang
Malignant melanoma (MM) is the most dangerous type of skin cancer, killing more than 1,100 people each year in Canada. Prognosis for late stage and recurrent MM is extremely poor due to insensitivity to chemotherapy drugs, and thus many patients seek complementary and alternative medicines. In this study, we examined four commonly used anticancer herbs in traditional Chinese medicine, Hedyotis diffusa, Scutellaria barbata, Lobelia chinensis, and Solanum nigrum, for their in vitro antitumor effects toward human MM cell line A-375...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27829423/relationship-between-traditional-chinese-medicine-constitutional-types-with-chemotherapy-induced-nausea-and-vomiting-in-patients-with-breast-cancer-an-observational-study
#14
Yi Liu, Ting Pan, Wenjing Zou, Ye Sun, Yun Cai, Rui Wang, Pingping Han, Zhe Zhang, Qunying He, Feng Ye
BACKGROUND: The theory of traditional Chinese medicine (TCM) constitution involves genetic characteristics, psychological factors, organ functions, and many other aspects. Studies have shown that TCM constitution is associated with HLA polymorphisms and has a genetic basis. A large number of Chinese studies have suggested that the clinical evolution of breast cancer may differ among patients with different TCM constitutions. In addition, patients with breast cancer and different TCM constitutions may have different degrees of myelosuppression after chemotherapy...
November 9, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27822287/traditional-chinese-medicine-use-among-patients-with-psoriasis-in-taiwan-a-nationwide-population-based-study
#15
Shu-Wen Weng, Bor-Chyuan Chen, Yu-Chiao Wang, Chun-Kai Liu, Mao-Feng Sun, Ching-Mao Chang, Jaung-Geng Lin, Hung-Rong Yen
Traditional Chinese medicine (TCM) has long been used for patients with psoriasis. This study aimed to investigate TCM usage in patients with psoriasis. We analyzed a cohort of one million individuals representing the 23 million enrollees randomly selected from the National Health Insurance Research Database in Taiwan. We identified 28,510 patients newly diagnosed with psoriasis between 2000 and 2010. Among them, 20,084 (70.4%) patients were TCM users. Patients who were female, younger, white-collar workers and lived in urbanized area tended to be TCM users...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27821648/novel-augmentation-by-bufalin-of-protein-kinase-c-induced-cyclooxygenase-2-and-il-8-production-in-human-breast-cancer-cells
#16
Hsiao-Ting Chen, David Sun, Yen-Chun Peng, Pu-Hong Kao, Yuh-Lin Wu
Cyclooxygenase-2 (COX-2) and IL-8 are two inflammatory mediators induced by protein kinase C (PKC) via various stimuli. Both contribute significantly to cancer progression. Bufalin, a major active component of the traditional Chinese medicine Chan Su, is known to induce apoptosis in various cancer cells. This study clarifies the role and mechanism of bufalin action during PKC regulation of COX-2/IL-8 expression and investigates the associated impact on breast cancer. Using MB-231 breast cancer cells, bufalin augments PKC induction of COX-2/IL-8 at both the protein and mRNA levels, and the production of prostaglandin E2 (PGE2) and IL-8...
November 7, 2016: Innate Immunity
https://www.readbyqxmd.com/read/27819370/competitive-profiling-of-celastrol-targets-in-human-cervical-cancer-hela-cells-via-quantitative-chemical-proteomics
#17
Yiqing Zhou, Weichao Li, Mingli Wang, Xixi Zhang, Haibing Zhang, Xiaofeng Tong, Youli Xiao
Celastrol, isolated from the traditional Chinese medicinal herb Tripterygium wilfordii Hook. f. (Thunder God's Vine), has been used to treat cancer, chronic inflammatory, autoimmune and other human diseases. However, to date, the protein targets and the mechanism of action of celastrol have remained elusive. In this study, we find that celastrol can react with protein thiols in a unique covalent and reversible manner, while protein denaturing disrupts the interaction. Through a competitive chemoproteomics approach utilizing a cysteine-targeting activity-based probe, we report the proteome-wide quantitative profiling of cellular targets of celastrol in human cervical cancer HeLa cells...
November 7, 2016: Molecular BioSystems
https://www.readbyqxmd.com/read/27806701/yi-ai-fang-a-traditional-chinese-herbal-formula-impacts-the-vasculogenic-mimicry-formation-of-human-colorectal-cancer-through-hif-1%C3%AE-and-epithelial-mesenchymal-transition
#18
Fenggang Hou, Wen Li, Qi Shi, Hongjia Li, Shanshan Liu, Shaoqi Zong, Jianlin Ren, Jie Chai, Jian Xu
BACKGROUND: Yi Ai Fang (YAF), a traditional Chinese medicine (TCM) formula, has been identified to have anticancer activity in our previously studies. The present study aimed to explore the potential mechanism of YAF suppression of VM on colorectal cancer (CRC) in vitro and in vivo. METHODS: Cell viability was measured by CCK-8 assay. HIF-1α, E-cd(E-cadherin), Claudin-4, and VIM (Vimentin) expressions level in vitro were evaluated by Western blot or RT-PCR. In addition, Human CRC HCT-116 cells were implanted in BALB/c nude mice; mice with xenografted tumors were randomly administrated vehicle (control), 8, 16, or 32 mg/mL YAF, or 1 mg/mL fluorouracil (5-FU)...
November 2, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27793785/autophagy-modulators-from-traditional-chinese-medicine-mechanisms-and-therapeutic-potentials-for-cancer-and-neurodegenerative-diseases
#19
REVIEW
Sheng-Fang Wang, Ming-Yue Wu, Cui-Zan Cai, Min Li, Jia-Hong Lu
ETHNOPHARMACOLOGICAL RELEVANCE: Traditional Chinese medicine (TCM), an ancient yet still alive medicinal system widely used in East Asia, has played an essential role in health maintenance and diseases control, for a wide range of human chronic diseases like cancers and neurodegenerative diseases. TCM-derived compounds and extracts attract wide attention for their potential application as therapeutic agents against above mentioned diseases. AIM OF REVIEW: Recent years the enthusiasm in searching for autophagy regulators for human diseases has yielded many positive hits...
October 25, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27784460/-effect-of-traditional-chinese-medicine-treatment-as-maintenance-therapy-on-regulating-the-serum-concentration-of-sctla-4-in-patients-with-advanced-non-small-cell-lung-cancer-and-its-relationship-with-prognosis
#20
Y Jiang, L B Wu, L P Shen, P Zhang, W J Jiang, J H Tian, L S Liu
Objective: To evaluate the effect of traditional Chinese medicine (TCM) treatment as maintenance therapy on regulating the serum concentration of soluble cytotoxic T lymphocyte associated antigen-4 (sCTLA-4) in patients with advanced non-small-cell lung cancer (NSCLC) and the relationship between sCTLA-4 and time to progression (TTP). Methods: This study was conducted as a prospective, randomized, controlled trial. 64 non-progressive patients who responded to initial therapy were randomized 1∶1 to the TCM arm (treated with cinobufacini injection, herbal decoction and Chinese acupoint application, n=32) or to the chemotherapy arm (n=32)...
October 23, 2016: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
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