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https://www.readbyqxmd.com/read/28436479/effects-of-chinese-medicine-as-adjunct-medication-for-adjuvant-chemotherapy-treatments-of-non-small-cell-lung-cancer-patients
#1
Lijing Jiao, Changsheng Dong, Jiaxiang Liu, Zhiwei Chen, Lei Zhang, Jianfang Xu, Xiaoyong Shen, Jiaming Che, Yi Yang, Hai Huang, Hegen Li, Jianli Sun, Yi Jiang, Zhujun Mao, Peiqi Chen, Yabin Gong, Xiaolin Jin, Ling Xu
The aim was to evaluate the effects of traditional Chinese medicine (TCM) as a combination medication with adjuvant chemotherapy on postoperative early stage non-small cell lung cancer (NSCLC) patients. The 314 patients with completely resected stage IB, II or IIIA cancers were assigned into vinorelbine plus cisplatin/carboplatin (NP/NC) (control, n = 158) and NP/NC with additional TCM (intervention, n = 156) groups. The primary endpoint was QOL scores; secondary endpoints were the toxicity and safety of the regimens...
April 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28432774/comprehensive-two-dimensional-pc-3-prostate-cancer-cell-membrane-chromatography-for-screening-anti-tumor-components-from-radix-sophorae-flavescentis
#2
Qiang Wang, Junnan Xu, Xiang Li, Dawei Zhang, Yong Han, Xu Zhang
Radix Sophorae flavescentis is generally used for the treatments of different stages of prostate cancer in China. It has ideal effects when combined with surgical treatment and chemotherapy. However, its active components are still ambiguous. We devised a comprehensive two-dimensional PC-3 prostate cancer cell membrane chromatography system for screening anti-prostate cancer components in Radix Sophorae flavescentis. Gefitinib and dexamethasone were chosen as positive and negative drugs respectively for validation and optimization the selectivity and suitability of the comprehensive two-dimensional chromatographic system...
April 22, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28427938/ganoderma-lucidum-reishi-suppresses-proliferation-and-migration-of-breast-cancer-cells-via-inhibiting-wnt-%C3%AE-catenin-signaling
#3
Yu Zhang
The medical mushroom Ganoderma lucidum (Reishi), a traditional Chinese medicine, has exhibited a promising anti-cancer effect. However, the molecular mechanism of its action on cancer cells remains unclear. Aberrant activation of Wnt/β-catenin signaling pathway is the cause of many types of cancer, including breast cancer. Here we investigated the effect of Reishi on Wnt/β-catenin signaling pathway and elucidated the molecular mechanism of its function in inhibiting breast cancer cells. We found that Reishi blocked Wnt/β-catenin signaling through inhibiting the phosphorylation of Wnt co-receptor LRP6...
April 17, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28422767/pseudolaric-acid-b-induces-endometrial-cancer-ishikawa-cell-apoptosis-and-inhibits-metastasis-through-akt-gsk-3%C3%AE-and-erk1-2-signaling-pathways
#4
Dan Wang, Yanqiu Tian, Wenhua Feng, Li Zhao, Mingyi Zhao, Ju Liu, Qiuyu Wang
Pseudolaric acid B (PAB) is the most active constituent extracted from the bark of Pseudolarix kaempferi, which has been used as an antifungal remedy in traditional Chinese medicine. It is reported to have cytotoxicity to many tumor cell lines. In this study, we investigated the effects of PAB against human endometrial cancer Ishikawa cells. We found that PAB inhibited Ishikawa cell proliferation, and induced cell apoptosis and G2/M phase arrest through a mechanism involving AKT-GSK-3β and ERK1/2 signaling pathways...
April 18, 2017: Anti-cancer Drugs
https://www.readbyqxmd.com/read/28420179/systematic-understanding-of-the-mechanism-of-salvianolic-acid-a-via-computational-target-fishing
#5
Shao-Jun Chen, Ming-Chao Cui
Salvianolic acid A (SAA) is one of the most abundant water-soluble and potent anti-oxidative compounds isolated from Danshen, a traditional Chinese medicine. A systematic overview of its mechanism of action is yet to be performed. In the present study, the druggability of SAA was measured using the TCMSP server, and potential targets of SAA were identified by PharmMapper and DRAR-CPI. Intersecting targets were then assessed by GeneMANIA and GO pathway analysis, and drug-target-pathway networks were constructed to give a visual view...
April 17, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28417089/demographic-and-medication-characteristics-of-traditional-chinese-medicine-users-among-colorectal-cancer-survivors-a-nationwide-database-study-in-taiwan
#6
Chien-Tung Wu, Yueh-Ting Tsai, Jung-Nien Lai
Chinese herbal product (CHP) is the major type of traditional Chinese medicine (TCM) and widely used to relief the symptom of colorectal cancer. The aim of the study was to analyze the utilization of CHP for treating patients with colorectal cancer in Taiwan. The usage of CHP, frequency of services, and prescription pattern for colorectal cancer were analyzed from a randomly sampled cohort of 1 million beneficiaries from the National Health Insurance Research Database. The odds ratios for utilization of CHP were estimated with logistic regression model...
April 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/28415616/z-ligustilide-restores-tamoxifen-sensitivity-of-era-negative-breast-cancer-cells-by-reversing-mta1-ifi16-hdacs-complex-mediated-epigenetic-repression-of-era
#7
Hui Ma, Li Li, Guojun Dou, Chengqiang Wang, Juan Li, Hui He, Mingxia Wu, Hongyi Qi
Emerging evidence indicates epigenetic modification represses estrogen receptor α (ERα) and contributes to the resistance to tamoxifen in aggressive ERα-negative (ERα-) breast cancer. Z-ligustilide is a major compound in Radix Angelica sinensis, an herb from traditional Chinese medicine (TCM) most frequently prescribed for breast cancer. However, the role of Z-ligustilide in ERα- breast cancer and epigenetic modification remains largely unknown. Herein we showed, for the first time, that Z-ligustilide restored the growth inhibition of tamoxifen on ERα- breast cancer cells...
March 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28414206/wenshen-zhuanggu-formula-effectively-suppresses-breast-cancer-bone-metastases-in-a-mouse-xenograft-model
#8
Jia-Jia Li, Wei-Ling Chen, Jian-Yi Wang, Qian-Wen Hu, Zhen-Ping Sun, Shuai Zhang, Sheng Liu, Xiang-Hui Han
Wenshen Zhuanggu formula (WSZG) is a traditional Chinese medicine used as an adjuvant for the prevention of bone metastases in breast cancer patients. In this study we investigated the efficacy of WSZG in preventing bone metastases and the potential mechanisms in a mouse xenograft model of breast cancer bone metastases. This model was established by injection of human MDA-MB-231BO-Luc breast cancer cells alone or a mixture of the cancer cells with bone marrow-derived mesenchymal stem cells (BMSCs) into left ventricle of the heart in female nude mice...
April 17, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28413465/protective-effects-of-baicalin-on-rabbit-articular-chondrocytes-in-vitro
#9
Xianyuan Huang, Huayu Wu, Liqin Wang, Li Zheng, Jinmin Zhao
Drug therapy is one of the typical treatments for post-injury inflammation of cartilage. Traditional Chinese herbs have potential as treatments, as their long history of clinical application has demonstrated they are effective and induce minimal side effects. Baicalin is a traditional Chinese medicine that has been used to treat inflammation, fever, ulcers and cancer for hundreds of years. Previous studies have demonstrated that baicalin may decrease levels of interleukin-1β and suppress the expression of type-I collagen, thus attenuating cartilage degeneration...
April 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28412678/clinical-study-of-lung-supplementing-and-stasis-dissolving-decoction-bufei-huayu-tang-combined-with-gefitnib-for-treatment-of-advanced-non-small-cell-lung-cancer
#10
Feng Yuan, Chen Si-Ning, Zhou Ji-Hong, Jiang Ying, Zhou Ying, Xie You-Ke, Li Jian-Zhe
To investigate the clinical efficacy and drug safety of Lung-Supplementing and Stasis-Dissolving Decoction (Bufei Huayu Tang) combined with gefitnib for treatment of advanced non-small cell lung cancer (NSCLC). Then, 80 patients with advanced NSCLC hospitalized in Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine were included, and were double-blindly randomized into 4 groups: control group (gefitinib alone 250mg, once daily), low-dose group (100mL/day), middle-dose group (150mL/day) and high-dose group (200mL/day) treated with different doses of Bufei Huayu Tang besides gefitinib...
November 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28412214/chinese-medicine-bu-fei-decoction-attenuates-epithelial-mesenchymal-transition-of-non-small-cell-lung-cancer-via-inhibition-of-transforming-growth-factor-%C3%AE-1-signaling-pathway-in-vitro-and-in-vivo
#11
Xi-Ran He, Shu-Yan Han, Xiao-Hong Li, Wen-Xian Zheng, Li-Na Pang, Shan-Tong Jiang, Ping-Ping Li
ETHNOPHARMACOLOGICAL RELEVANCE: Traditional Chinese medicine Bu-Fei decoction (BFD) has been utilized to treat patients with Qi deficiency for decades, with the advantages of invigorating vital energy, clearing heat-toxin and moistening lung, etc. According to previous clinical experience and trials, BFD has been found to indeed improve life quality of lung cancer patients and prolong survival time. Nevertheless, little is known on its potential mechanisms so far. Being regarded as a pivotal cytokine in the tumor microenvironment, transforming growth factor β (TGF-β) stands out as a robust regulator of epithelial-mesenchymal transition (EMT), which is closely linked to tumor progression...
April 12, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28408846/apoptotic-and-genomic-effects-of-corilagin-on-skov3-ovarian-cancer-cell-line
#12
Rukset Attar, Zeynep Birsu Cincin, Elif Sinem Bireller, Bedia Cakmakoglu
Corilagin is a member of the tannin family and has been isolated from traditional Chinese medicinal plants, such as Phyllanthus spp. Corilagin has anti-inflammatory, antioxidative, antiatherogenic, and antihypertensive effects in various experimental models. In this research, we aimed to investigate for the first time whether corilagin had apoptotic and genomic effects in ovarian cancer treatment in the same study. The potential apoptotic of corilagin was investigated using a WST1 cell proliferation test, caspase 3, and mitochondrial membrane potential JC1 assays in a time- and dose-dependent manner...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28407686/tumor-stage-and-primary-treatment-of-hepatocellular-carcinoma-at-a-large-tertiary-hospital-in-china-a-real-world-study
#13
Jian-Hong Zhong, Ning-Fu Peng, Xue-Mei You, Liang Ma, Xiao Xiang, Yan-Yan Wang, Wen-Feng Gong, Fei-Xiang Wu, Bang-De Xiang, Le-Qun Li
The current clinical reality of tumor stages and primary treatments of hepatocellular carcinoma (HCC) is poorly understood. This study reviewed the distribution of tumor stages and primary treatment modalities among a large population of patients with primary HCC. Medical records of patients treated between January 2003 and October 2013 for primary HCC at our tertiary hospital in China were retrospectively reviewed. A total of 6241 patients were analyzed. The distribution of Barcelona Clinic Liver Cancer (BCLC) stages was as follows: stage 0/A, 28...
March 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/28404902/mechanism-of-modulation-through-pi3k-akt-pathway-about-nepeta-cataria-l-s-extract-in-non-small-cell-lung-cancer
#14
Jiaxin Fan, Yongrui Bao, Xiansheng Meng, Shuai Wang, Tianjiao Li, Xin Chang, Guanlin Yang, Tao Bo
Non-small cell lung cancer (NSCLC) is regarded as one of the major intractable diseases, which was cured mainly by chemotherapeutics in the clinical treatment at present. But it is still a vital mission for the current medical and researchers that hunting a natural medicine which have little side effects and high-efficiency against the NSCLC on account of the shortcomings on current drugs. Nepeta cataria L. plays an important role in anti-cancer treatment according to the reports which was recorded in the Chinese Pharmacopoeia of version 2015 and belongs to one of the Traditional Chinese medicine (TCM)...
February 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28386190/establishment-of-apoptotic-regulatory-network-for-genetic-markers-of-colorectal-cancer-and-optimal-selection-of-traditional-chinese-medicine-target
#15
Tongde Tian, Chuanliang Chen, Feng Yang, Jingwen Tang, Junwen Pei, Bian Shi, Ning Zhang, Jianhua Zhang
The paper aimed to screen out genetic markers applicable to early diagnosis for colorectal cancer and establish apoptotic regulatory network model for colorectal cancer, and to analyze the current situation of traditional Chinese medicine (TCM) target, thereby providing theoretical evidence for early diagnosis and targeted therapy of colorectal cancer. Taking databases including CNKI, VIP, Wanfang data, Pub Med, and MEDLINE as main sources of literature retrieval, literatures associated with genetic markers that are applied to early diagnosis of colorectal cancer were searched and performed comprehensive and quantitative analysis by Meta analysis, hence screening genetic markers used in early diagnosis of colorectal cancer...
March 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28383512/screening-and-analysis-of-the-marker-components-in-ganoderma-lucidum-by-hplc-and-hplc-ms-n-with-the-aid-of-chemometrics
#16
Lingfang Wu, Wenyi Liang, Wenjing Chen, Shi Li, Yaping Cui, Qi Qi, Lanzhen Zhang
Ganoderma triterpenes (GTs) are the major secondary metabolites of Ganoderma lucidum, which is a popularly used traditional Chinese medicine for complementary cancer therapy. The present study was to establish a fingerprint evaluation system based on Similarity Analysis (SA), Cluster Analysis (CA) and Principal Component Analysis (PCA) for the identification and quality control of G. lucidum. Fifteen samples from the Chinese provinces of Hainan, Neimeng, Shangdong, Jilin, Anhui, Henan, Yunnan, Guangxi and Fujian were analyzed by HPLC-PAD and HPLC-MS(n)...
April 6, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28382147/gambogenic-acid-synergistically-potentiates-bortezomib-induced-apoptosis-in-multiple-myeloma
#17
Runzhe Chen, Hongming Zhang, Ping Liu, Xue Wu, Baoan Chen
Background: Although the introduction of protease inhibitor bortezomib (BTZ) and immunomodulatory agent lenalidomide has led to improved outcomes in patients with multiple myeloma (MM), the disease remains incurable. Gambogenic acid (GNA), a polyprenylated xanthone isolated from the traditional Chinese medicine gamboge, has been reported to have potent antitumor activity and can effectively inhibit the survival and proliferation of cancer. In this study, we hypothesized that GNA could synergistically potentiate BTZ-induced apoptosis of MM cells and that combining BTZ and GNA may provide a more effective approach to treat MM...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28363523/cordycepin-enriched-wib-801c-from-cordyceps-militaris-improves-functional-recovery-by-attenuating-blood-spinal-cord-barrier-disruption-after-spinal-cord-injury
#18
Jee Youn Lee, Hye Young Choi, Hyung Hwan Baik, Bong G Ju, Won-Ki Kim, Tae Young Yune
ETHNOPHARMACOLOGICAL RELEVANCE: Cordyceps militaris is an ingredient of traditional Chinese medicine and have been widely used for inflammatory diseases and cancer. Cordycepin is one of the major bioactive components of Cordyceps militaris, and has been known to have anti-inflammatory and anti-oxidant effects. AIM OF THIS STUDY: In the present study, we examined whether WIB-801C, a standardized and cordycepin-enriched extract of caterpillar fungus (Cordyceps militaris), would attenuate blood-spinal cord barrier (BSCB) disruption by inhibiting matrix metalloprotease (MMP)-9 activity, leading to improvement of functional outcomes after spinal cord injury (SCI)...
May 5, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28363522/reversal-of-multidrug-resistance-by-marsdenia-tenacissima-and-its-main-active-ingredients-polyoxypregnanes
#19
Kenneth K W To, Xu Wu, Chun Yin, Stella Chai, Sheng Yao, Onat Kadioglu, Thomas Efferth, Yang Ye, Ge Lin
ETHNOPHARMACOLOGICAL RELEVANCE: Multidrug resistance (MDR) of cancer is often associated with the overexpression of ATP-binding cassette (ABC) transporters, such as P-glycoprotein (P-gp), multidrug resistance-associated protein-1 (MRP-1) and breast cancer resistance protein (BCRP or ABCG2), in cancer cells, which facilitates the active efflux of a wide variety of chemotherapeutic drugs out of the cells. Marsdenia tenacissima is a traditional Chinese medicinal herb that has long been clinically used for treatment of cancers, particularly in combinational use with anticancer drugs...
May 5, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28359849/a-review-on-traditional-uses-phytochemistry-pharmacology-pharmacokinetics-and-toxicology-of-the-genus-peganum
#20
REVIEW
Shuping Li, Xuemei Cheng, Changhong Wang
ETHNOPHARMACOLOGICAL RELEVANCE: The plants of the genus Peganum have a long history as a Chinese traditional medicine for the treatment of cough, hypertension, diabetes, asthma, jaundice, colic, lumbago, and many other human ailments. Additionally, the plants can be used as an amulet against evil-eye, dye and so on, which have become increasingly popular in Asia, Iran, Northwest India, and North Africa. AIM OF THE REVIEW: The present paper reviewed the ethnopharmacology, phytochemistry, analytical methods, biological activities, metabolism, pharmacokinetics, toxicology, and drug interaction of the genus Peganum in order to assess the ethnopharmacological use and to explore therapeutic potentials and future opportunities for research...
May 5, 2017: Journal of Ethnopharmacology
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