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https://www.readbyqxmd.com/read/28093974/anticancer-properties-of-traditional-chinese-medicine
#1
Zhaokun Yan, Zijun Lai, Jiumao Lin
Cancer is a systemic disease. Cancer occurrence is associated with several factors, including cell proliferation, apoptosis, metastasis, tumor microenvironment and immune system. Traditional Chinese medicine (TCM) has been widely used for thousands of years in China for its anti-cancer therapeutic effect. The advantage of using TCM is related to its action on multiple signaling pathways and molecular targets related to cancer, whilst causing few adverse effects. TCM exerts its anticancer effects through multiple mechanisms, including apoptosis induction, proliferation inhibition, metastasis suppression, multidrug resistance reversal and immune function regulation...
January 16, 2017: Combinatorial Chemistry & High Throughput Screening
https://www.readbyqxmd.com/read/28088780/national-survey-of-china-s-oncologists-knowledge-attitudes-and-clinical-practice-patterns-on-complementary-and-alternative-medicine
#2
Geliang Yang, Richard Lee, Huiqing Zhang, Wei Gu, Peiying Yang, Changquan Ling
It is common for cancer patients to use complementary and alternative medicine (CAM). This study was designed to explore China's oncologists' knowledge, attitudes and clinical practices regarding CAM use by their patients. An online survey was conducted of China's oncologists. Among 11,270 participants who completed the online survey, 6,007 (53.3%) were identified as oncologists. Most were men (75.2%), with a mean age of 33.4 (standard deviation: 6.5) years. The 6,007 oncologists discussed with 36.5% of their patients about CAM...
January 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28088493/apoptosis-induced-by-the-methanol-extract-of-salvia-miltiorrhiza-bunge-in-non-small-cell-lung-cancer-through-pten-mediated-inhibition-of-pi3k-akt-pathway
#3
Yin-Tao Ye, Wei Zhong, Pei Sun, Dong Wang, Chen Wang, Li-Min Hu, Jun-Qiang Qian
ETHNOPHARMACOLOGICAL RELEVANCE: Salvia miltiorrhiza Bunge, a well-known traditional Chinese medicinal (TCM) plant, has been used to treat cardiovascular diseases since thousands of years. Many studies have reported that the active component tanshinones displayed a variety of biological activities: antithrombous, antiplatelet aggregation, antioxidant and antitumor promoting. But the mechanism of how the active components working still need to be clarified. The anti-tumor effect of compounds of tanshinone (CTN), the methanol extract of Salvia miltiorrhiza Bunge roots, was investigated...
January 11, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28068355/a-methodology-for-cancer-therapeutics-by-systems-pharmacology-based-analysis-a-case-study-on-breast-cancer-related-traditional-chinese-medicines
#4
Yan Li, Jinghui Wang, Feng Lin, Yinfeng Yang, Su-Shing Chen
Breast cancer is the most common carcinoma in women. Comprehensive therapy on breast cancer including surgical operation, chemotherapy, radiotherapy, endocrinotherapy, etc. could help, but still has serious side effect and resistance against anticancer drugs. Complementary and alternative medicine (CAM) may avoid these problems, in which traditional Chinese medicine (TCM) has been highlighted. In this section, to analyze the mechanism through which TCM act on breast cancer, we have built a virtual model consisting of the construction of database, oral bioavailability prediction, drug-likeness evaluation, target prediction, network construction...
2017: PloS One
https://www.readbyqxmd.com/read/28067535/long-term-survival-of-aids-patients-treated-with-only-traditional-chinese-medicine
#5
Yifei Wang, Fujun Jin, Qiaoli Wang, Zucai Suo
Traditional Chinese herbal medicine (TCM) has been used in Chinese society for more than 5,000 years to treat diseases from inflammation to cancer. Here, we report the case of nine living AIDS patients in the age range of 51 to 67 who were treated with either a unique formula of TCM alone from 2001 to 2009 or the TCM from 2001 to 2006 and then switched to occasional antiretroviral therapy. Surprisingly, the viral loads of eight patients were at undetectable levels on June 28, 2016 while the remaining patient had a low viral load of 29 copies/ml...
January 9, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/28059040/natural-products-targeting-egfr-signaling-pathways-as-potential-anticancer-drugs
#6
Xiaoyu Wang, Linfeng Xu, Yuanzhi Lao, Hongmei Zhang, Hongxi Xu
The epidermal growth factor receptor (EGFR) belongs to ErbB family of tyrosine kinases, which plays an important role in the regulation of cell proliferation, survival, differentiation, and metastasis. In addition, tumors develop resistance to EGFR inhibitors due to the presence or development of point mutations in the tyrosine kinase domain of the receptor. There is an urgent need to develop new anti-EGFR agents with strong therapeutic activities. As the majority of anticancer drugs are of natural origin, natural products are a valuable source for the identification and development of novel treatment options for cancer...
January 5, 2017: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/28056563/a-survey-of-licensed-acupuncturists-in-the-san-francisco-bay-area
#7
Donald Abrams, Michael McCulloch, Misha Cohen, Mike Liaw, Deborah Silverman, Carla Wilson
BACKGROUND: Many cancer patients seek traditional Chinese medicine (TCM), the prevalence varying with diagnosis, comorbidities, and demographics. Interventions sought include acupuncture, massage, herbs, diet, and exercise, usually combined with conventional therapies. It is not known what proportion of TCM practitioners care for cancer patients, their cancer specific training or caseload, what interventions they employ, their outcomes, and their communication patterns with conventional oncologists...
January 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/28049093/regulation-of-different-components-from-ophiopogon-japonicus-on-autophagy-in-human-lung-adenocarcinoma-a549cells-through-pi3k-akt-mtor-signaling-pathway
#8
Juan Chen, Jiarui Yuan, Liqiang Zhou, Maomao Zhu, Ziqi Shi, Jie Song, Qingyu Xu, Guowen Yin, You Lv, Yi Luo, Xiaobin Jia, Liang Feng
Autophagy plays a dual role in the development of cancer, acting as both a tumor suppressor and a cell survival inducer. Ophiopogon japonicus (L.f) Ker-Gawl (OJ), as a traditional Chinese medicine, specially possesses remarkable anti-cancer activity in the clinical. Previously, studies have indicated that flavonoids (FOJ) and steroidal saponins (SSOJ) are the main active substances of OJ. However, the effects of FOJ and SSOJ on autophagy of A549 cells have not been fully elucidated. In this study, we found that the expressions of autophagy-related mediators (LC3-II/LC3-I ratio, Atg-3, Atg-7 and Beclin-1) were increased in A549 cells by the treatment with FOJ (7...
December 31, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28048515/th-ab-207a-09-tailoring-tcm-schemes-to-a-task-evaluating-the-impact-of-customized-tcm-profiles-on-detection-of-lung-nodules-in-simulated-ct-lung-cancer-screening
#9
J Hoffman, F Noo, S Young, M McNitt-Gray
PURPOSE: Recent work has shown that current TCM profile designs boost detection of low-contrast lung lesions in the lung apices, but yield reduced detection performance in the mid and lower lung regions relative to fixed tube current cases. This observed imbalance suggests that the TCM scheme might be tailored in new ways to maximize nodule detection throughout the entire lung. In this work, we begin a preliminary investigation into custom TCM profiles in an attempt to achieve uniform lesion detection throughout the extent of the lung...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047912/tu-h-207a-08-estimating-radiation-dose-from-low-dose-lung-cancer-screening-ct-exams-using-tube-current-modulation
#10
A Hardy, M Bostani, K McMillan, M Zankl, C Cagnon, M McNitt-Gray
PURPOSE: The purpose of this work is to estimate effective and lung doses from a low-dose lung cancer screening CT protocol using Tube Current Modulation (TCM) across patient models of different sizes. METHODS: Monte Carlo simulation methods were used to estimate effective and lung doses from a low-dose lung cancer screening protocol for a 64-slice CT (Sensation 64, Siemens Healthcare) that used TCM. Scanning parameters were from the AAPM protocols. Ten GSF voxelized patient models were used and had all radiosensitive organs identified to facilitate estimating both organ and effective doses...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047903/th-ab-201-10-portal-dosimetry-with-elekta-iviewdose-performance-of-the-simplified-commissioning-approach-versus-full-commissioning
#11
M Kydonieos, A Folgueras, L Florescu, T Cybulski, N Marinos, G Thompson, A Sayeed, R Rozendaal, I Olaciregui-Ruiz, A Subiel, I Silvestre Patallo
PURPOSE: Elekta recently developed a solution for in-vivo EPID dosimetry (iViewDose, Elekta AB, Stockholm, Sweden) in conjunction with the Netherlands Cancer Institute (NKI). This uses a simplified commissioning approach via Template Commissioning Models (TCMs), consisting of a subset of linac-independent pre-defined parameters. This work compares the performance of iViewDose using a TCM commissioning approach with that corresponding to full commissioning. Additionally, the dose reconstruction based on the simplified commissioning approach is validated via independent dose measurements...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28012398/traditional-chinese-medicine-jianpi-bushen-therapy-suppresses-the-onset-of-pre-metastatic-niche-in-a-murine-model-of-spontaneous-lung-metastasis
#12
Xiaoyun Zhu, Yu Zhou, Qiu Xu, Jie Wu
BACKGROUND & AIM: Distinct metastasis accounts for the leading cause of mortality among patients with gastric cancer. The formation of pre-metastatic niche in the target organs provides permissive environments for the adhesion and subsequent growth of metastasized cancer cells. Targeting the pre-metastatic niche is a potential approach to prevent metastasis. Traditional Chinese medicine regimen called Jianpi Bushen therapy (JPBS) has been widely used in clinics to strengthen patients' abilities to fight cancer...
December 21, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27999546/protocatechuic-aldehyde-attenuates-cisplatin-induced-acute-kidney-injury-by-suppressing-nox-mediated-oxidative-stress-and-renal-inflammation
#13
Li Gao, Wei-Feng Wu, Lei Dong, Gui-Ling Ren, Hai-Di Li, Qin Yang, Xiao-Feng Li, Tao Xu, Zeng Li, Bao-Ming Wu, Tao-Tao Ma, Cheng Huang, Yan Huang, Lei Zhang, Xiongwen Lv, Jun Li, Xiao-Ming Meng
Cisplatin is a classic chemotherapeutic agent widely used to treat different types of cancers including ovarian, head and neck, testicular and uterine cervical carcinomas. However, cisplatin induces acute kidney injury by directly triggering an excessive inflammatory response, oxidative stress, and programmed cell death of renal tubular epithelial cells, all of which lead to high mortality rates in patients. In this study, we examined the protective effect of protocatechuic aldehyde (PA) in vitro in cisplatin-treated tubular epithelial cells and in vivo in cisplatin nephropathy...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27989101/overcomes-imatinib-resistance-by-depleting-bcr-abl-in-chronic-myeloid-leukemia
#14
Xiaoyan Sun, Xueting Cai, Jie Yang, Jiao Chen, Caixia Guo, Peng Cao
Cantharidin (CTD) is an active compound isolated from the traditional Chinese medicine blister beetle and displayed anticancer properties against various types of cancer cells. However, little is known about its effect on human chronic myeloid leukemia (CML) cells, including imatinib-resistant CML cells. The objective of this study was to investigate whether CTD could overcome imatinib resistance in imatinib-resistant CML cells and to explore the possible underlying mechanisms associated with the effect. Our results showed that CTD strongly inhibited the growth of both imatinib-sensitive and imatinib-resistant CML cells...
December 2016: Molecules and Cells
https://www.readbyqxmd.com/read/27988397/total-coumarins-of-hedyotis-diffusa-induces-apoptosis-of-myelodysplastic-syndrome-skm-1-cells-by-activation-of-caspases-and-inhibition-of-pi3k-akt-pathway-proteins
#15
Jianping Jiang, Bo Wang, Jing Li, Baodong Ye, Shengyun Lin, Wenbin Qian, Letian Shan, Thomas Efferth
ETHNOPHARMACOLOGICAL RELEVANCE: Hedyotis diffusa is an ethno-medicine used for anti-cancer treatment in the clinic of traditional Chinese medicine (TCM). The total coumarins of Hedyotis diffusa (TCHD) was a selected extract with observed antiproliferative activity, which has not been tested in treatment of myelodysplastic syndromes (MDS) or acute myeloid leukemia (AML). AIM OF THE STUDY: This study aimed to evaluate the apoptosis-inducing effect of TCHD on human MDS cell line (SKM-1) and explore its action mechanism in association with caspase family and PI3K/Akt signaling pathway...
January 20, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27986736/efficacy-and-safety-of-wuling-san-for-treatment-of-breast-cancer-related-upper-extremity-lymphoedema-study-protocol-for-a-pilot-trial
#16
Huiru Zhu, Zheng Peng, Meiyu Dai, Yan Zou, Fengxian Qin, Jifei Chen, Liuying Song, Baoyu He, Xiaolan Lv, Shengming Dai
INTRODUCTION: Breast-cancer-related upper extremity lymphoedema (BCUL), a common complication of mastectomy, can cause physical discomfort, psychological distress, cosmetic defects, functional disability and chronic recurrent erysipelas in the affected arm(s). It is a challenge to physicians involved in the management of these patients. Wuling San, a classic prescription in Traditional Chinese Medicine used in treating oedema for thousands of years, is reported by many Chinese journals to perform well in BCUL...
December 16, 2016: BMJ Open
https://www.readbyqxmd.com/read/27983570/anti-fatigue-effect-by-peptide-fraction-from-protein-hydrolysate-of-croceine-croaker-pseudosciaena-crocea-swim-bladder-through-inhibiting-the-oxidative-reactions-including-dna-damage
#17
Yu-Qin Zhao, Li Zeng, Zui-Su Yang, Fang-Fang Huang, Guo-Fang Ding, Bin Wang
The swim bladder of the croceine croaker (Pseudosciaena crocea) was believed to have good curative effects in various diseases, including amnesia, insomnia, dizziness, anepithymia, and weakness after giving birth, in traditional Chinese medicine. However, there is no research focusing on the antioxidant and anti-fatigue peptides from croceine croaker swim bladders at present. Therefore, the purpose of this study was to investigate the bioactivities of peptide fractions from the protein hydrolysate of croceine croaker related to antioxidant and anti-fatigue effects...
December 13, 2016: Marine Drugs
https://www.readbyqxmd.com/read/27982058/shengmai-formula-suppressed-over-activated-ras-mapk-pathway-in-c-elegans-by-opening-mitochondrial-permeability-transition-pore-via-regulating-cyclophilin-d
#18
Yan Liu, Dejuan Zhi, Menghui Li, Dongling Liu, Xin Wang, Zhengrong Wu, Zhanxin Zhang, Dongqing Fei, Yang Li, Hongmei Zhu, Qingjian Xie, Hui Yang, Hongyu Li
Since about 30% of all human cancers contain mutationally activated Ras, down regulating the over-activation of Ras/MAPK pathway represents a viable approach for treating cancers. Over-activation of Ras/MAPK pathway is accompanied by accumulation of reactive oxygen species (ROS). One approach for developing anti-cancer drugs is to target ROS production and their accumulation. To test this idea, we have employed C. elegans of let-60 (gf) mutant, which contain over-activated let-60 (the homolog of mammalian ras) and exhibit tumor-like symptom of multivulva phenotype, to determine whether anti-oxidants can affect their tumor-like phenotype...
December 16, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27979664/saponin-fraction-isolated-from-conyza-blinii-h-l%C3%A3-v-demonstrates-strong-anti-cancer-activity-that-is-due-to-its-nf-%C3%AE%C2%BAb-inhibition
#19
Long Ma, Haiyan Liu, Ping Qin, Chenxi Hu, Shuli Man, Yuyin Li, Zhen Liu, Zhenxing Liu, Aipo Diao
CBS (Conyza blinii saponin) is the total triterpenoidal saponins of Conyza blinii H.Lév which is a type of traditional Chinese medicine (TCM). We have discovered that CBS has a profound cytostatic activity against a range of solid tumour cells in a time- and dose-dependent manner. We also confirm that the cytostatic activity of CBS originates from its apoptosis induction effect. Additionally, we use immunoblot to find out that the apoptosis induction effect of CBS is attributable to the activation of mitochondrial pathway...
December 12, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27975690/a-prototype-traditional-chinese-medicinal-plant-library-at-the-national-cancer-institute
#20
M He, T Grkovic, C C Thornburg, J Whitt, R Akee, J Thompson, J Britt, L Jia, J White, D Newman, B O'Keefe
No abstract text is available yet for this article.
December 2016: Planta Medica
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