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https://www.readbyqxmd.com/read/29147652/identification-of-potent-chloride-intracellular-channel-protein-1-inhibitors-from-traditional-chinese-medicine-through-structure-based-virtual-screening-and-molecular-dynamics-analysis
#1
Wei Wang, Minghui Wan, Dongjiang Liao, Guilin Peng, Xin Xu, Weiqiang Yin, Guixin Guo, Funeng Jiang, Weide Zhong, Jianxing He
Chloride intracellular channel 1 (CLIC1) is involved in the development of most aggressive human tumors, including gastric, colon, lung, liver, and glioblastoma cancers. It has become an attractive new therapeutic target for several types of cancer. In this work, we aim to identify natural products as potent CLIC1 inhibitors from Traditional Chinese Medicine (TCM) database using structure-based virtual screening and molecular dynamics (MD) simulation. First, structure-based docking was employed to screen the refined TCM database and the top 500 TCM compounds were obtained and reranked by X-Score...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29143796/angelica-sinensis-polysaccharides-ameliorate-stress-induced-premature-senescence-of-hematopoietic-cell-via-protecting-bone-marrow-stromal-cells-from-oxidative-injuries-caused-by-5-fluorouracil
#2
Hanxianzhi Xiao, Lirong Xiong, Xiaoying Song, Pengwei Jin, Linbo Chen, Xiongbin Chen, Hui Yao, Yaping Wang, Lu Wang
Myelosuppression is the most common complication of chemotherapy. Decline of self-renewal capacity and stress-induced premature senescence (SIPS) of hematopoietic stem cells (HSCs) induced by chemotherapeutic agents may be the cause of long-term myelosuppression after chemotherapy. Whether the mechanism of SIPS of hematopoietic cells relates to chemotherapeutic injury occurred in hematopoietic microenvironment (HM) is still not well elucidated. This study explored the protective effect of Angelica sinensis polysaccharide (ASP), an acetone extract polysaccharide found as the major effective ingredients of a traditional Chinese medicinal herb named Chinese Angelica (Dong Quai), on oxidative damage of homo sapiens bone marrow/stroma cell line (HS-5) caused by 5-fluorouracil (5-FU), and the effect of ASP relieving oxidative stress in HM on SIPS of hematopoietic cells...
October 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29140496/association-between-use-of-traditional-chinese-medicine-herbal-therapy-and-survival-outcomes-in-patients-with-stage-ii-and-iii-colorectal-cancer-a-multicenter-prospective-cohort-study
#3
Yun Xu, Jun J Mao, Lingyun Sun, Lin Yang, Jie Li, Yingxu Hao, Huashan Li, Wei Hou, Yuping Chu, Yu Bai, Xiaoqiang Jia, Jinwan Wang, Lin Shen, Ying Zhang, Jianbin Wang, Jianping Liu, Yufei Yang
Background: Chinese cancer patients often use Traditional Chinese Medicine (TCM) herbal medicine during or after active cancer treatments. However, little is known about how TCM herbal medicine impacts cancer outcomes. This study aimed to evaluate the association between TCM herbal therapy and survival outcomes in patients with stage II or III colorectal cancer. Methods: We conducted an eight-center prospective cohort study in China among patients who had undergone radical resection for stage II and III colorectal cancer...
November 1, 2017: Journal of the National Cancer Institute. Monographs
https://www.readbyqxmd.com/read/29140491/validation-and-application-of-the-md-anderson-symptom-inventory-for-traditional-chinese-medicine-mdasi-tcm
#4
Zhandong Li, Qiuling Shi, Meng Liu, Liqun Jia, Bin He, Yufei Yang, Jie Liu, Hongsheng Lin, Huei-Kai Lin, Pingping Li, Xin Shelley Wang
Background: The MD Anderson Symptom Inventory (MDASI) is a brief, yet thorough, patient-reported outcomes measure for assessing the severity of common cancer-related symptoms and their interference with daily functioning. We report the development of an MDASI version tailored for use with Traditional Chinese Medicine in China (the MDASI-TCM). Methods: Chinese-speaking patients with mixed cancer types (n = 317) participated in the study. The development and validation process included four steps: 1) identify candidate TCM-specific items, with input from patients, oncologists, and TCM specialists; 2) eliminate candidate TCM items lacking relevance, based on patient report; 3) psychometrically examine the MDASI-TCM's validity and reliability in cancer patients receiving TCM-based care; and 4) cognitively debrief patients to assess the MDASI-TCM's relevance, understandability, and acceptability...
November 1, 2017: Journal of the National Cancer Institute. Monographs
https://www.readbyqxmd.com/read/29138573/matrine-suppresses-the-migration-and-invasion-of-nsclc-cells-by-inhibiting-pax2-induced-epithelial-mesenchymal-transition
#5
Jun Yang, Du He, Yan Peng, Hongzhen Zhong, Yuhong Deng, Zhonghua Yu, Chengnong Guan, Yufang Zuo, Zumin Xu
Non-small cell lung cancer (NSCLC) is the major cause of deaths among all the cancer types worldwide. Most of the NSCLC is diagnosed at an advanced stage and the 5-year overall survival rate is low. The reason for the low survival rate of patients with NSCLC is mainly due to distant metastasis. Matrine, a traditional Chinese medicine, has been shown a significant anti-proliferation and anti-invasive effect in tumors. However, little is known on the anti-invasive mechanism of matrine in lung cancer. Therefore, we tried to investigate the molecular mechanism of matrine on the invasive ability of NSCLC cells in vitro...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29138518/predicted-molecular-targets-and-pathways-for-germacrone-curdione-and-furanodiene-in-the-treatment-of-breast-cancer-using-a-bioinformatics-approach
#6
Qi Kong, Yong Ma, Jie Yu, Xiuping Chen
Germacrone, curdione, and furanodiene have been shown to be useful in the treatment of breast cancer but the pharmacological mechanism of action is unclear. In this paper, we explored a new method to study the molecular network and function of Traditional Chinese Medicine (TCM) herbs and their corresponding ingredients with bioinformatics tools, including PubChem Compound Database, BATMAN-TCM, SystemsDock, Coremine Medical, Gene ontology, and KEGG. Eleven targeted genes/proteins, 4 key pathways, and 10 biological processes were identified to participate in the mechanism of action in treating breast cancer with germacrone, curdione, and furanodiene...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29138340/phase-i-study-of-chimeric-antigen-receptor-modified-t-cells-in-patients-with-egfr-positive-advanced-biliary-tract-cancers
#7
Yelei Guo, Kai-Chao Feng, Yang Liu, Zhiqiang Wu, Hanren Dai, Qing-Ming Yang, Yao Wang, Hejin Jia, Weidong Han
PURPOSE: This study is an expanded and parallel clinical trial of epidermal growth factor receptor (EGFR)-specific chimeric antigen receptor-engineered autologous T (CART) cell immunotherapy (NCT01869166) to assess the safety and activity of CART-EGFR cell therapy in EGFR-positive advanced unresectable, relapsed/metastatic biliary tract cancers (BTCs). PATIENTS AND METHODS: Patients with EGFR-positive (>50%) advanced unresectable, relapsed/metastatic BTCs were enrolled...
November 14, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29137114/natural-cyclopeptide-ra-xii-a-new-autophagy-inhibitor-suppresses-protective-autophagy-for-enhancing-apoptosis-through-ampk-mtor-p70s6k-pathways-in-hepg2-cells
#8
Lihua Song, Zhe Wang, Yurong Wang, Di Guo, Jianhong Yang, Lijuan Chen, Ninghua Tan
Liver cancer is a progressive, irreversible and aggressive malignant disease, which has no effective chemotherapeutic drugs. RA-XII, a natural cyclopeptide isolated from the traditional Chinese medicine Rubia yunnanensis, exerts anti-cancer and anti-inflammatory activities. This work aimed to investigate the effects of RA-XII on a hepatic tumor and its underlying mechanisms in human hepatoma HepG2 cells. The results showed that RA-XII effectively inhibited the proliferation of HepG2 cells. Consistently, RA-XII significantly induced apoptosis in HepG2 cells by decreasing the expression of caspase 3, 8, 9, and promoting the Cleavage of PARP...
November 11, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29133049/design-and-synthesis-of-novel-c14-urea-tetrandrine-derivatives-with-potent-anti-cancer-activity
#9
Junjie Lan, Lan Huang, Huayong Lou, Chao Chen, Tangjingjun Liu, Shengcao Hu, Yao Yao, Junrong Song, Jun Luo, Yazhou Liu, Bin Xia, Lei Xia, Xueyi Zeng, Yaacov Ben-David, Weidong Pan
Tetrandrine is a dibenzyltetrahydroisoquinoline alkaloid, isolated from traditional Chinese medicinal plant Stephania tetrandra, with anti-tumor activity. Our previous study identified several derivatives of tetrandrine showing better activities than parental compound against human hepatocellular carcinoma cells. To increase diversity and cytotoxic activities of the original compound, a series of novel 14-urea-tetrandrine derivatives were synthesized through structural modification of tetrandrine. These derivaties demonstrated a moderate to strong anti-proliferative activities against human cell lines HEL and K562 (Leukemia), prostate (PC3), breast (MDA-MB-231) and melanoma (WM9)...
November 6, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29130769/neuroprotective-effects-and-uplc-q-tof-ms-based-active-components-identification-of-external-applied-a-novel-wen-luo-tong-microemulsion
#10
Hong-Mei Lin, Long-Fei Lin, Zhen-Zhen Xia, Yong Mao, Jia Liu, Ling-Yan Xu, Qing Wu
Chemotherapy induced neuropathy causes excruciating pain to cancer patients. Wen-Luo-Tong (WLT), a traditional Chinese medicinal compound, has been used to alleviate anti-cancer drug such as oxaliplatin-induced neuropathic pain for many years. However, the current route of administration of WLT is inconvenient and the active ingredients and mechanism of action of WLT are still unclear. To address these issues, we developed a novel formulation of WLT (W/O microemulsion) for the ease of application. New ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS) methods were employed for analysis of the ingredients...
November 13, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29127567/the-root-of-actinidia-chinensis-inhibits-hepatocellular-carcinomas-cells-through-lamb3
#11
Jiayun Hou, Lingyan Wang, Duojiao Wu
The root of Actinidia chinensis, as traditional Chinese medicine, has been shown to inhibit cell proliferation in numerous cancer cells. However, the mechanisms underlying its inhibitory activity remain unclear. Death rates of hepatocellular carcinoma (HCC) are increasing, but therapies for advanced HCC are not well developed. We choose the extract from root of Actinidia chinensis (ERAC) to treat the HCC cell lines in vitro, displaying distinct effects on cell proliferation, S-phase cell cycle arrest, and apoptosis...
November 10, 2017: Cell Biology and Toxicology
https://www.readbyqxmd.com/read/29119970/hispidulin-mediates-apoptosis-in-human-renal-cell-carcinoma-by-inducing-ceramide-accumulation
#12
Hui Gao, Ming-Quan Gao, Jian-Jun Peng, Mei Han, Kai-Li Liu, Yan-Tao Han
Hispidulin, a polyphenolic flavonoid extracted from the traditional Chinese medicinal plant S involucrata, exhibits anti-tumor effects in a wide array of human cancer cells, mainly through growth inhibition, apoptosis induction and cell cycle arrest. However, its precise anticancer mechanisms remain unclear. In this study, we investigated the molecular mechanisms that contribute to hispidulin-induced apoptosis of human clear-cell renal cell carcinoma (ccRCC) lines Caki-2 and ACHN. Hispidulin (10, 20 μmol/L) decreased the viability of ccRCC cells in dose- and time-dependent manners without affecting that of normal tubular epithelial cells...
November 9, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29115554/paeoniflorin-influences-breast-cancer-cell-proliferation-and-invasion-via-inhibition-of-the-notch%C3%A2-1-signaling-pathway
#13
Jing Zhang, Kun Yu, Xuedong Han, Linlin Zhen, Minmin Liu, Xiwen Zhang, Yi Ren, Jianhua Shi
Breast cancer is one of the most frequently occurring malignant tumors affecting women's health. At least one million new cases are diagnosed each year. Therefore, research that aims to identify strategies that inhibit the growth of breast cancer cells has become a primary worldwide focus. Traditional Chinese medicine (TCM) is regarded as a valuable resource in China, and numerous monomer compositions extracted from TCMs have been demonstrated to exhibit antitumor effects. The present study aimed to determine the impact of paeoniflorin (PF) on breast cancer cell proliferation and invasion, and to explore the mechanisms underlying its effects...
November 7, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29115462/hedyotis%C3%A2-diffusa-willd-inhibits-proliferation-and-induces-apoptosis-of-5%C3%A2-fu-resistant-colorectal-cancer-cells-by-regulating-the-pi3k-akt-signaling-pathway
#14
Qiongyu Li, Zijun Lai, Zhaokun Yan, Jun Peng, Yiyi Jin, Lihui Wei, Jiumao Lin
Hedyotis diffusa Willd (HDW) is a major component frequently used in Traditional Chinese Medicine for the clinical treatment of colorectal cancer (CRC) and its associated drug resistance. However, the underlying mechanism of HDW circumventing drug resistance of cancer cells remains to be elucidated. Cancer cell resistance to apoptosis and activation of the phosphatidylinositol‑3‑kinase (PI3K)/protein kinase B (AKT) signaling pathway have been implicated as major factors in the acquired resistance to chemotherapeutic anti‑cancer drugs...
October 26, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29103462/anti-proliferation-activity-of-terpenoids-isolated-from-euphorbia-kansui-in-human-cancer-cells-and-their-structure-activity-relationship
#15
Jin-Jun Hou, Yao Shen, Zhou Yang, Lin Fang, Lu-Ying Cai, Shuai Yao, Hua-Li Long, Wan-Ying Wu, De-An Guo
Euphorbia kansui is a commonly used traditional Chinese medicine for the treatment of edema, pleural effusion, and asthma, etc. According to the previous researches, terpenoids in E. kansui possess various biological activities, e.g., anti-virus, anti-allergy, antitumor effects. In this work, twenty five terpenoids were isolated from E. kansui, including thirteen ingenane- and eight jatrophane-type diterpenoids (with two new compounds, kansuinin P and Q) and four triterpenoids. Eighteen of them were analyzed by MTS assay for in vitro anticancer activity in five human cancer cell lines...
October 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29103417/traditional-chinese-medicine-integrated-with-chemotherapy-for-stage-iv-non-surgical-gastric-cancer-a-retrospective-clinical-analysis
#16
Xuan Liu, Li-Juan Xiu, Jian-Peng Jiao, Jing Zhao, Ying Zhao, Ye Lu, Jun Shi, Yong-Jin Li, Min Ye, Yu-Fang Gu, Xiao-Wei Wang, Jing-Yu Xu, Ci-An Zhang, Yong-Ying Liu, Yun Luo, Xiao-Qiang Yue
OBJECTIVE: Traditional Chinese medicine (TCM) is regarded as an important treatment for gastric cancer patients, especially for those in advanced stage. To evaluate the effects of TCM treatment on gastric cancer patients, the authors performed a retrospective study to report the result of the integrated treatment of TCM with chemotherapy for stage IV non-surgical gastric cancer. METHODS: In this study, 182 patients with stage IV and non-surgical gastric cancer were retrospectively analyzed to evaluate the effects of TCM integrated with chemotherapy...
November 2017: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29102767/curcuzedoalide-contributes-to-the-cytotoxicity-of-curcuma-zedoaria-rhizomes-against-human-gastric-cancer-ags-cells-through-induction-of-apoptosis
#17
Eun Bee Jung, Tuy An Trinh, Tae Kyoung Lee, Noriko Yamabe, Ki Sung Kang, Ji Hoon Song, Sungyoul Choi, Sang Hyun Lee, Tae Su Jang, Ki Hyun Kim, Gwi Seo Hwang
ETHNOPHARMACOLOGICAL RELEVANCE: Curcuma zedoaria Roscoe (Zingiberaceae), also known as white turmeric or zedoaria, has been used in Ayurveda and traditional Chinese medicine to treat various cancers, and it possesses several sesquiterpenoid compounds. OBJECTIVE: This study aimed to evaluate the therapeutic effects of a methanolic (MeOH) extract of C. zedoaria rhizomes, as well as its active constituents, against gastric cancer, which is a frequently diagnosed cancer in South Korea...
November 1, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29100416/natural-autophagy-blockers-dauricine-dac-and-daurisoline-das-sensitize-cancer-cells-to-camptothecin-induced-toxicity
#18
Ming-Yue Wu, Sheng-Fang Wang, Cui-Zan Cai, Jie-Qiong Tan, Min Li, Jin-Jian Lu, Xiu-Ping Chen, Yi-Tao Wang, Wei Zheng, Jia-Hong Lu
Autophagy is a cellular bulk degradation pathway implicated in various diseases. Inhibition of autophagy has been regarded as a new therapeutic strategy for cancer treatment, especially in combination with chemotherapy. In our study, we identified two natural compounds, dauricine (DAC) and daurisoline (DAS), as two potent autophagy blockers through a high-content screening. DAC and DAS are alkaloids isolated from traditional Chinese medicine Rhizoma Menispermi. We systematically examined the effects of DAC and DAS on autophagy function in HeLa cells and found that DAC and DAS induced massive formation of autophagic vacuoles and lipidation of LC3...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29100379/gambogic-acid-inhibits-thioredoxin-activity-and-induces-ros-mediated-cell-death-in-castration-resistant-prostate-cancer
#19
Hong Pan, Keith H Jansson, Michael L Beshiri, JuanJuan Yin, Lei Fang, Supreet Agarwal, Holly Nguyen, Eva Corey, Ying Zhang, Jie Liu, HuiTing Fan, HongSheng Lin, Kathleen Kelly
Advanced prostate cancer (PrCa) is treated with androgen deprivation therapy, and although there is usually a significant initial response, recurrence arises as castrate resistant prostate cancer (CRPC). New approaches are needed to treat this genetically heterogeneous, phenotypically plastic disease. CRPC with combined homozygous alterations to PTEN and TP53 comprise about 30% of clinical samples. We screened eleven traditional Chinese medicines against a panel of androgen-independent Pten/Tp53 null PrCa-derived cell lines and identified gambogic acid (GA) as a highly potent growth inhibitor...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29100031/research-on-major-antitumor-active-components-in-zi-cao-cheng-qi-decoction-based-on-hollow-fiber-cell-fishing-with-high-performance-liquid-chromatography
#20
Miaomiao Li, Shuang Hu, Xuan Chen, Runqin Wang, Xiaohong Bai
Hollow fiber cell fishing (HFCF) based on hepatoma HepG-2 cells, human renal tubular ACHN cells or human cervical carcinoma HeLa cells, coupled with high-performance liquid chromatography (HPLC), was developed and employed to research the major active components in Zi-Cao-Cheng-Qi decoction both in vitro and in vivo. The research showed that the active components, such as hesperidin, magnolol, honokiol, shikonin, emodin and β,β'-dimethylacrylshikonin were screened out by HFCF based on the cancer cells in vitro, furthermore they can be absorbed into blood and reach in the target organ, and some of the active components can be fished by the cells and maintain effective concentrations...
October 28, 2017: Journal of Pharmaceutical and Biomedical Analysis
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