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colon caner

Rongfei Han, Guanqun Huang, Yejun Wang, Yafei Xu, Yueming Hu, Wenqi Jiang, Tianfu Wang, Tian Xiao, Duo Zheng
Gene expression in metazoans is delicately organized. As genetic information transmits from DNA to RNA and protein, expression noise is inevitably generated. Recent studies begin to unveil the mechanisms of gene expression noise control, but the changes of gene expression precision in pathologic conditions like cancers are unknown. Here we analyzed the transcriptomic data of human breast, liver, lung and colon cancers, and found that the expression noise of more than 74.9% genes was increased in cancer tissues as compared to adjacent normal tissues...
October 4, 2016: Oncotarget
Wonyoung Choi, Jungwoo Lee, Jin-Young Lee, Sun-Min Lee, Da-Won Kim, Young-Joon Kim
Diverse somatic mutations have been reported to serve as cancer drivers. Recently, it has also been reported that epigenetic regulation is closely related to cancer development. However, the effect of epigenetic changes on cancer is still elusive. In this study, we analyzed DNA methylation data on colon cancer taken from The Caner Genome Atlas. We found that several promoters were significantly hypermethylated in colon cancer patients. Through clustering analysis of differentially methylated DNA regions, we were able to define subgroups of patients and observed clinical features associated with each subgroup...
June 2016: Genomics & Informatics
Chun-Ting Kuo, Chieh Chang, Wen-Sen Lee
To investigate the molecular mechanism underlying folic acid (FA)-induced anti-colon caner activity, we showed that FA caused G0/G1 arrest in COLO-205. FA activated the proto-oncogene tyrosine-protein kinase Src (c-SRC)-mediated signaling pathway to enhance nuclear factor of kappa light polypeptide gene enhancer in B-cells (NFκB) nuclear translocation and binding onto the tumor protein p53 (TP53) gene promoter, and up-regulated expressions of TP53, cyclin-dependent kinase inhibitor 1A (CDKN1A) and cyclin-dependent kinase inhibitor 1B (CDKN1B)...
2015: Scientific Reports
Luis E Becker, Daniela Siebert, Caner Süsal, Gerhard Opelz, Albrecht Leo, Rüdiger Waldherr, Stephan Macher-Goeppinger, Peter Schemmer, Sebastian Markus Schaefer, Katrin Klein, Jörg Beimler, Martin Zeier, Vedat Schwenger, Christian Morath
BACKGROUND: For desensitization of ABO-incompatible kidney transplant recipients we recently proposed nonantigen-specific immunoadsorption (IA) and rituximab. METHODS: We now compared clinical outcomes of 34 ABO-incompatible living-donor kidney recipients who were transplanted using this protocol with that of 68 matched ABO-compatible patients. In addition, we analyzed efficacy and cost of nonantigen-specific as compared to blood group antigen-specific IA. RESULTS: Before desensitization, the median isoagglutinin titer of 34 ABO-incompatible patients was 1:64 (Coombs technique)...
November 2015: Transplantation
Kiichiro Tsuchiya
Gastrointestinal cancer such as gastric cancer and colon caner, occupies the majority of the cause of death due to the malignant tumor. Although some progress about the conquest of cancer is accepted through early diagnosis and the development of the endoscope treatment, the treatment, which directly targets the molecular mechanism of the carcinogenesis, is still poor. It therefore is necessary to analyze a process of carcinogenesis in detail. While the gene abnormality as the cause of cancer has been gradually clarified, the characteristic of the cancer stem cell has recently attracted as novel target for cancer therapy...
May 2015: Nihon Rinsho. Japanese Journal of Clinical Medicine
Ancheng Qin, Qiang Yu, Yuan Gao, Jifu Tan, Hai Huang, Zhiming Qiao, Weifeng Qian
BACKGROUND: Chemotherapeutic resistance indicated the poor prognosis of colorectal cancer. OBJECTIVE: Our study aimed to investigate the role of STAT3/cyclinD1 pathway in the chemotherapeutic resistance of colorectal cancer. METHODS: We firstly measured the expression of cyclinD1 in the colorectal cancer tissues using immunohistochemistry in tissue microarray. Then cell viability and apoptosis were investigated in the HT-29 cell lines dealing with recombinant lentivirus and shRNA to increase or decrease cyclinD1 expression...
February 20, 2015: Biochemical and Biophysical Research Communications
Caner Kılıç, Ümit Tunçel, Ela Cömert
OBJECTIVES: This study aims to determine the problems of patients applied provox 2 voice prosthesis for speech rehabilitation with their prosthesis and our treatment modalities to increase the quality of life of these patients. PATIENTS AND METHODS: A total of 210 patients (180 males, 30 females; mean age 58±11.9 years; range 37 to 83 years) who underwent total laryngectomy, applied and changed provox 2 voice prosthesis for voice restoration were included in the study...
November 2014: Kulak Burun Boğaz Ihtisas Dergisi: KBB, Journal of Ear, Nose, and Throat
Xin-Xiang Li, Li-Yong Huang, Jun-Jie Peng, Lei Liang, De-Bing Shi, Hong-Tu Zheng, San-Jun Cai
Klotho (KL) was originally characterized as an aging suppressor gene, and has been identified as a tumor suppressor gene in a variety of cancers including colon cancer. However, the potential role and molecular events for KL in colon cancer remain unclear. The present study aimed to investigate the expression of KL in human colon cancer by immunohistochemistry, and to analyze the correlation between KL expression and clinicopathological characteristics of patients with colon cancer. Functional analysis after lentivirus-mediated gain of KL expression was used to assess the tumor growth and invasion in colon cancer cells in vitro and in vivo...
August 2014: International Journal of Oncology
Lin Ye, Kaixiong Tao, Yang Yu, Guobin Wang
OBJECTIVE: A major problem in the chemotherapy of colon caner may be due to those cells that are in residence in the G0 phase where they are less vulnerable to conventional therapy. To overcome this phenomenon, we attempted to recruit the reentry of these cells into the cell cycle via a signaling pathway that manipulates tumor growth. METHODS: Epidermal growth factor (EGF) was used to stimulate colon cancer caco-2 cells. FACS analysis and proliferating cell nuclear antigen (PCNA) staining were used to estimate the cell cycle transition and cell proliferation activated by EGF, and a MTT assay was used to evaluate the synergistic effect of EGF and chemotherapy...
January 2010: Journal of Biomedical Research
Hüseyin Can, Ayşe Caner, Mert Döşkaya, Aysu Değirmenci, Sabire Karaçalı, Ceylan Polat, Yüksel Gürüz, Ahmet Uner
BACKGROUND: Detection of Pneumocystis jiroveci colonization in lungs or oral samples due to high sensitivity of PCR methods results in undue treatment of patients without any symptoms of Pneumocystis pneumonia. The aim of the present study is to demonstrate Pneumocystis carinii in rats, immune suppressed by oral and subcutaneous administration of dexamethasone. MATERIAL/METHODS: Blood, oral, nasal and eye swabs were collected prior to immune suppression and 2, 6, 12 weeks after administration of dexamethasone...
2013: Medical Science Monitor Basic Research
Qin Ma, Lie Yang, Cun Wang, Yong-Yang Yu, Bin Zhou, Zhong-Guang Zhou
OBJECTIVE: To investigate the miRNA expression difference between colon cancer and normal colonic mucosa. METHODS: Twelve (12) pairs of colorectal cancer tissue and normal colonic mucosa were collected, total RNA was extracted and purified. After fluorescent tags being added, hybridization was carried out on miRNA microarray chip (Affymetrix company). SAM analysis was performed to find out the significant expression difference, then the difference was verified by RT-PCR, finally target gene analysis software was utilized to predict the miRNA function...
May 2011: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
Jun Sun
Inflammation plays a critical role in the development of cancer. Matrix Metalloproteinase (MMP) functions in the remodeling of the extracellular matrix that is integral for many normal and pathological processes such as morphogenesis, angiogenesis, tissue repair, and tumor invasion. The tissue inhibitor of metalloproteinases (TIMPs) family regulates the activity of multifunctional metalloproteinases. In this paper, we discuss the role and mechanism of MMP and TIMP in regulating inflammation responses in solid tumors...
2010: Journal of Signal Transduction
Caner B Baran, Derya Mutlu, Betil O Baysan, Filiz Günseren, Ayla Ergani, Dilara Oğünç, Dilek Colak
The identification of community-acquired methicillin-resistant Staphylococcus aureus (MRSA) is becoming a hard task since colonization with MRSA is lasting for years and the number of the health care facilities other than hospitals is continuously increasing. In this study we aimed to investigate the genetic properties and health-care association of MRSA strains isolated from skin and soft tissue infections of outpatients admitted to Akdeniz University Hospital. Thirty strains were phenotypically identified as MRSA and after assessing the risk factors, 28 (93...
October 2010: Mikrobiyoloji Bülteni
Shaheena Khan, Jennifer L Taylor, Carrie W Rinker-Schaeffer
Ovarian cancer affects approximately 25,000 women in the United States each year and remains one of the most lethal female malignancies. A standard approach to therapy is surgical cytoreduction, after which the remaining microscopic residual disease is treated with chemotherapy. The vast majority of patients have disease recurrence, underscoring the crucial need for approaches to control the regrowth, or colonization, of tissues after local treatment. Improved therapies require mechanistic information about the process of metastatic colonization, the final step in metastasis, in which cancer cells undergo progressive growth at secondary sites...
2010: Journal of Oncology
John J Liang, Sadir Alrawi, Dongfeng Tan
Serrated adenomas (SAs) are part of the distinct serrated polyp pathway of colorectal carcinogenesis characterized by microsatellite instability and deficiency in DNA mismatch repair. Sessile SA is a recently recognized lesion that typically presents as a large sessile polyp, but lacks the conventional dysplasia. It is more frequently found on the right side than on the left side of the colon, and is thought to represent an intermediate form in the hyperplastic polyp to sessile SA, traditional SA, and colon cancer sequence...
2008: International Journal of Clinical and Experimental Pathology
Dong Kyung Chang, Young Ho Kim, Jeong Sik Byeon, Suk Kyun Yang, Yong Woo Chung, Dong Soo Han, Sang Gyun Kim, Tae Il Kim, Won Ho Kim, Yoon Tae Jeen, Chang Soo Eun, Hwang Choi, Kyu Yong Choi, In Sung Song et al.
BACKGROUND/AIMS: The number of patients with ulcerative colitis has steadily increased since the mid-1980s. As the risk of colon cancer increases with duration and extents, colitic cancers are expected to increase in number in Korea. We surveyed the current status of colitic cancers and provided the perspectives in Korea. METHODS: Korean Association for the Study of Intestinal Diseases (KASID) collected and descriptively analyzed a total of eleven cases of colitic cancers occurred between 1993 and 2003...
October 2005: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
Caner Cavdar, Tuba Atay, Mujdat Zeybel, Ali Celik, Ayse Ozder, Serkan Yildiz, Zeynep Gulay, Taner Camsari
In the present study, we evaluated the effects of once-weekly mupirocin application to catheter exit sites on Staphylococcus aureus and coagulase-negative staphylococcus (CNS) colonization and investigated the resistance of those bacteria to methicillin (MeR) and mupirocin (MuR). We enrolled 36 continuous ambulatory peritoneal dialysis (CAPD) patients (mean age: 55.1 +/- 1.4 years) into the study. The patients (men/women: 21/15) had been applying mupirocin to the catheter exit site once weekly before the start of the study (mupirocin treatment duration: 3...
2004: Advances in Peritoneal Dialysis
Feng Xu, Ying-Jiang Ye, Shan Wang
AIM: The prevention of recurrence of colon cancer (CC) after operation is very important for improvement of the prognosis of CC patients, especially those with micro-metastasis. The generation of fused cells between dendritic cells (DCs) and tumor cells maybe an effective approach for tumor antigen presentation in immunotherapy. In this study, we fused human colon caner SW480 cells and human peripheral blood - derived DCs to induce an antitumor activity against human CC. METHODS: CC SW480 cells and human peripheral blood - derived DCs were fused with 500 mL/L polyethylene glycol (PEG)...
April 15, 2004: World Journal of Gastroenterology: WJG
D Hock
Colon cancer is the second most common cause of cancer death and the first one in non-smoking persons. None of the current colorectal caner screening options is ideal. As for mammography in breast cancer screening, virtual colonoscopy, although still in clinical evaluation, promises to become a primary screening method as it is performant, quick, non-invasive and cheaper than conventional colonoscopy.
May 2003: Revue Médicale de Liège
A G Thompson
BACKGROUND: It is known that there are ethnic differences in cancer in New Zealand between Maori (the indigenous people) and non-Maori, however, until now no regional comparisons have been made. STUDY DESIGN: A retrospective study of patients diagnosed at Whangarei Hospital, New Zealand between 1995 and 1997 with gastric or colonic cancer was combined with population data from the 1996 census for Whangarei District to calculate incidence figures. The incidence of cancer was compared to national rates...
July 2002: Postgraduate Medical Journal
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