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https://www.readbyqxmd.com/read/28717937/clinical-presentation-and-outcomes-of-childhood-onset-membranous-lupus-nephritis
#1
Maria Pereira, Eyal Muscal, Karen Eldin, M John Hicks, Anna Carmela P Sagcal-Gironella, Marietta DeGuzman, Scott E Wenderfer
BACKGROUND: Best practices for managing childhood-onset membranous lupus nephritis (MLN) are not yet established. Most studies involve primarily or exclusively adult cohorts or pediatric cohorts with combinations of pure or mixed membranous and proliferative nephritis. METHODS: We performed a single-center cohort study of consecutively diagnosed children with pure MLN from 1990 and 2016. Patients received care in Houston, Texas, one of the most diverse metropolitan areas in North America...
July 17, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28685717/variants-in-the-promoter-region-of-hla-dqa1-were-associated-with-idiopathic-membranous-nephropathy-in-a-chinese-han-population
#2
Xiao-Song Qin, Jian-Hua Liu, Guan-Ting Lyu, Meng-Le Peng, Fu-Ning Yang, Dong-Chun Qin, Yong-Zhe Li, Yong Liu
BACKGROUND: Idiopathic membranous nephropathy (IMN) is an autoimmune disease and the leading cause of adult nephritic syndrome. HLA-DQA1 had been identified to be associated with IMN in Europeans and the result was replicated in Chinese Han population. In this study, six single nucleotide polymorphisms (SNPs) in the promoter of HLA-DQA1 and other two SNPs with IgA nephropathy were included for the association analysis. METHODS: The SNPs were genotyped in 509 patients and 601 controls by the MassArray iPLEX...
July 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28638602/b-cell-depleting-therapy-with-rituximab-or-ofatumumab-in-immunoglobulin-a-nephropathy-or-vasculitis-with-nephritis
#3
Sigrid Lundberg, Emelie Westergren, Jessica Smolander, Annette Bruchfeld
BACKGROUND: Approximately 30% of adult patients with immunoglobulin A (IgA) nephropathy (IgAN) or IgA vasculitis with nephritis (IgAVN) develop end-stage renal disease during long-term follow-up. In particular, patients with nephritic-nephrotic syndrome have an increased risk of rapid progression. Conventional immunosuppressive therapy with corticosteroids (CSs) may be insufficient for disease control and is associated with a number of side effects. Rituximab (RTX) has been shown to be well tolerated and effective in a range of glomerular diseases, but there is little information on its therapeutic potential in IgAN...
February 2017: Clinical Kidney Journal
https://www.readbyqxmd.com/read/28339709/clinicopathologic-correlations-of-renal-pathology-in-the-adult-population-of-poland
#4
Agnieszka Perkowska-Ptasinska, Artur Bartczak, Malgorzata Wagrowska-Danilewicz, Agnieszka Halon, Krzysztof Okon, Aldona Wozniak, Marian Danilewicz, Henryk Karkoszka, Andrzej Marszalek, Jolanta Kowalewska, Andrzej Mroz, Agnieszka Korolczuk, Andrzej Oko, Alicja Debska-Slizien, Beata Naumnik, Zbigniew Hruby, Marian Klinger, Kazimierz Ciechanowski, Marek Myslak, Wladyslaw Sulowicz, Andrzej Rydzewski, Andrzej Wiecek, Jacek Manitius, Tadeusz Gregorczyk, Stanislaw Niemczyk, Michal Nowicki, Ryszard Gellert, Tomasz Stompor, Monika Wieliczko, Krzysztof Marczewski, Leszek Paczek, Olga Rostkowska, Dominika Deborska-Materkowska, Grazyna Bogdanowicz, Andrzej Milkowski, Magdalena Durlik
Background: This is the first report on the epidemiology of biopsy-proven kidney diseases in Poland. Methods: The Polish Registry of Renal Biopsies has collected information on all (n = 9394) native renal biopsies performed in Poland from 2009 to 2014. Patients' clinical data collected at the time of biopsy, and histopathological diagnoses were used for epidemiological and clinicopathologic analysis. Results: There was a gradual increase in the number of native renal biopsies performed per million people (PMP) per year in Poland in 2009-14, starting from 36 PMP in 2009 to 44 PMP in 2014...
April 1, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28098102/evaluation-of-renal-lesions-and-clinicopathologic-correlation-in-rheumatoid-arthritis
#5
Periyasamy Muthukumar, Jeyachandran Dhanapriya, Natarajan Gopalakrishnan, Thanigachalam Dineshkumar, Ramanathan Sakthirajan, T Balasubramaniyan
The most common causes of renal disease in rheumatoid arthritis (RA) are glomerulonephritis (GN), amyloidosis, tubulo-interstitial nephritis, and drug toxicity. Our aim was to evaluate the clinicopathologic correlation of renal lesions and to assess the course and prognosis of renal disease in patients with RA. We conducted a prospective observational study in all adult patients with RA between July 2010 and June 2015. The total number of patients studied was 90, with a female:male ratio of 2.3:1. Mean follow-up duration was 30 ± 6...
January 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/27576285/-henoch-sch%C3%A3-nlein-purpura-in-a-cocaine-consumer-man-with-hiv-infection-and-anca-p-positivity
#6
María C De Paoli, Dino Moretti, Carlos M Scolari Pasinato, Martín G Buncuga
The Henoch-Schönlein purpura (HSP) is a small vessel vasculitis with IgA immune complex deposition. The presentation in adults is rare and severe. Reported cases of HSP in patients infected with HIV are scarce. Neutrophil cytoplasmic antibodies (ANCA) are commonly found in other systemic vasculitis, but rarely in HSP and even more unusual the perinuclear pattern. Beside small vessel vasculitis, positivity of ANCA can be detected in a number of different pathological conditions in association with infectious processes, including HIV, or cocaine use, and especially the pattern of ANCA-p, associated with drugs, inflammatory bowel or autoimmune diseases...
2016: Medicina
https://www.readbyqxmd.com/read/27049363/frequency-and-clinical-histological-analysis-of-glomerular-diseases-in-a-tertiary-hospital-in-southern-brazil
#7
Camila Crensiglova, Bárbara Benevides Rehme, Letícia Raysa Schiavon Kinasz, Domingos Candiota Chula, Marcelo Mazza do Nascimento, Maria Fernanda Sanches Soares
INTRODUCTION: The glomerulopathies are the most common biopsy-proven kidney diseases. The epidemiological investigation of glomerulopathies allows the identification of their distribution and main causes and enables the development of prevention and treatment strategies. OBJECTIVE: This study aims to identify the frequency and clinical-pathological correlation of glomerular diseases diagnosed at the HC-UFPR over the period of 5 years. METHODS: 131 biopsies were performed between January 1, 2008 and December 31, 2012 and were analysed by light and immunofluorescence microscopy...
March 2016: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/27015208/predictors-of-relapse-in-adult-onset-nephrotic-minimal-change-disease
#8
Hajeong Lee, Kyung Don Yoo, Yun Kyu Oh, Dong Ki Kim, Kook-Hwan Oh, Kwon Wook Joo, Yon Su Kim, Curie Ahn, Jin Suk Han, Chun Soo Lim
Minimal change disease (MCD) is a well-known benign primary glomerulonephritis because of its distinct rare tendency to progress to end-stage renal disease. However, factors associated with relapse in adults are not well known. We aimed to identify predictors of relapse in adult-onset MCD patients.A retrospective cohort of 195 patients with adult-onset primary MCD with nephritic syndrome and disease onset between 1979 and 2013 was followed up for >12 months. The number of relapses was counted and predictors of relapse were analyzed...
March 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27008597/cordyceps-militaris-fruit-body-extract-ameliorates-membranous-glomerulonephritis-by-attenuating-oxidative-stress-and-renal-inflammation-via-the-nf-%C3%AE%C2%BAb-pathway
#9
Jingjing Song, Yingwu Wang, Chungang Liu, Yan Huang, Liying He, Xueying Cai, Jiahui Lu, Yan Liu, Di Wang
Membranous glomerulonephritis (MGN) is a common pathogenesis of nephritic syndrome in adult patients. Nuclear factor kappa B (NF-κB) serves as the main transcription factor for the inflammatory response mediated nephropathy. Cordyceps militaris, containing various pharmacological components, has been used as a kind of crude drug and folk tonic food for improving immunity and reducing inflammation. The current study aims to investigate the renoprotective activity of Cordyceps militaris aqueous extract (CM) in the cationic bovine serum albumin (C-BSA)-induced rat model of membranous glomerulonephritis...
April 2016: Food & Function
https://www.readbyqxmd.com/read/26856980/insight-to-changing-morphologic-patterns-of-glomerulopathy-in-adult-pakistani-patients-an-institutional-perspective
#10
Atif Ali Hashmi, ZubaidaFida Hussain, Muhammad Muzzammil Edhi, Shazia Mumtaz, Naveen Faridi, Mehmood Khan
BACKGROUND: Idiopathic nephrotic syndrome encompasses diverse histogenetic patterns and depicts socioeconomic and demographic differences attributable to genetic profile, environmental factors and prevalence of infectious diseases. A lack of renal registry in our country necessitates a need to document changing histologic patterns of nephrotic syndrome as noted in different parts of the world. METHODS: We retrospectively analyzed 140 patients who underwent renal biopsy at Liaquat National Hospital from January 2009 to December 2013 over a period of 3 years...
February 8, 2016: BMC Research Notes
https://www.readbyqxmd.com/read/26640759/c1q-nephropathy-the-unique-underrecognized-pathological-entity
#11
REVIEW
Joe Devasahayam, Gowrishankar Erode-Singaravelu, Zeenat Bhat, Tony Oliver, Arul Chandran, Xu Zeng, Paramesh Dakshinesh, Unni Pillai
C1q nephropathy is a rare glomerular disease with characteristic mesangial C1q deposition noted on immunofluorescence microscopy. It is histologically defined and poorly understood. Light microscopic features are heterogeneous and comprise minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), and proliferative glomerulonephritis. Clinical presentation is also diverse, and ranges from asymptomatic hematuria or proteinuria to frank nephritic or nephrotic syndrome in both children and adults...
2015: Analytical Cellular Pathology (Amsterdam)
https://www.readbyqxmd.com/read/26354589/kidney-biopsy-in-the-military-hospital-of-morocco-complications-and-histopathological-findings
#12
Yassir Zajjari, Taoufiq Aatif, Abdelali Bahadi, Kawtar Hassani, Driss El Kabbaj, Mohamed Benyahia
Epidemiological studies on renal biopsies are necessary to establish the pattern and trends of renal diseases in a particular geographic area. In this retrospective study, we reviewed the medical records, histopathology findings and complications of renal biopsy in a region of Morocco. We studied a total of 130 native kidney biopsies taken between January 2008 and January 2012. All biopsies were examined by light microscopy and immunofluorescence microscopy. There were 86 males (66.2%) and 44 females (33.8%), with a mean patient age of 44...
September 2015: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/26328648/effects-of-cyclophosphamide-pulse-therapy-on-the-clinical-and-histopathological-findings-particularly-crescent-formation-in-a-patient-with-adult-onset-steroid-refractory-henoch-sch%C3%A3-nlein-purpura-nephritis
#13
Yusuke Tanaka, Yuri Nakashima, Toru Mima, Masaki Ohya, Shuto Yamamoto, Sou Kobayashi, Asuka Masumoto, Koji Masumoto, Takurou Yano, Mari Moribata, Wataru Yoshimoto, Shintaro Yamanaka, Daisuke Koreeda, Yoshiyuki Hanba, Koichi Tatsuta, Toshifumi Sakaguchi, Shigeo Negi, Takashi Shigematsu
A 29-year-old woman was diagnosed with Henoch-Schönlein purpura nephritis (HSPN) based on the presence of purpura and histopathological findings showing crescent formation, mesangial proliferation and IgA deposition in the glomerular mesangium. She was treated with high-dose steroids; however, the nephritic syndrome persisted. Therefore, we diagnosed her with steroid-resistant HSPN and decided to add treatment with cyclosphamide pulse therapy. After one year of treatment, the histopathological findings, including crescent formation and IgA deposition, improved, as confirmed on a renal biopsy, and the patient fulfilled the criteria for complete remission...
2015: Internal Medicine
https://www.readbyqxmd.com/read/26289290/novel-factor-h-mutation-associated-with-familial-membranoproliferative-glomerulonephritis-type-i
#14
Hadas Alfandary, Miriam Davidovits
BACKGROUND: Idiopathic membranoproliferative glomerulonephritis (MPGN) is a rare disease, accounting for 3-5% of all cases of primary nephritic syndrome. We report an uncommon case of familial MPGN type I associated with a new mutation in the complement factor H gene (CFH). METHODS: Clinical data were collected on three siblings with known factor H deficiency who presented with MPGN. All underwent immunological and genetic assays. Their parents and ten healthy adults served as controls for the DNA analysis...
December 2015: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/26281194/-impact-of-interleukin-10-and-interleukin-28-gene-polymorphisms-on-the-development-and-course-of-lupus-nephritis
#15
T N Krasnova, L M Samokhodskaya, L V Ivanitsky, A D Korogodina, E N Borisov, N V Nikiforova, P I Novikov, A A Kamalov, N A Mukhin
AIM: To assess the relationship of the carriage of IL-10-1080 G/A and IL-28 rs8099917 C/T polymorphisms to the course of lupus nephritis (LN). SUBJECTS AND METHODS: Ninety-nine patients with systemic lupus erythematosus (SLE), including 68 with LN, were examined. Gene polymorphisms were analyzed using standard molecular genetic techniques. The frequency of the clinical manifestations of LN was analyzed; renal survival (RS) was estimated by the Kaplan-Meier method...
2015: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/26281193/-urinary-biomarkers-for-podocyte-injury-significance-for-evaluating-the-course-and-prognosis-of-chronic-glomerulonephritis
#16
N V Chebotareva, I N Bobkova, N V Neprintseva, L V Kozlovskaya, Z T Malkandueva
AIM: To estimate the degree of podocyte injury in patients with different types of chronic glomerulonephritis (CGN) from the urinary level of podocyte markers and to determine the significance of these indicators as criteria for disease activity and prognosis. SUBJECTS AND METHODS: Seventy-three patients with CGN, including 20 with inactive nephritis (Group 1), 23 with obvious urological syndrome (Group 2), 30 with nephrotic syndrome (NS) (Group 3), among them there were 7 patients with severe NS and 7 with NS concurrent with acute nephritic syndrome, were examined...
2015: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/26275270/acute-postinfectious-glomerulonephritis-with-a-large-number-of-crescents-caused-by-mycoplasma-pneumoniae
#17
Xinghua Chen, Wanwen Xu, Juan Du, Huiming Wang
Mycoplasma pneumoniae-induced acute postinfectious glomerulonephritis has various pathological changes and relatively poor prognosis. It often occurs in children, barely in adults. Currently, no clear treatment guidelines have been established for its treatment using glucocorticoid and immunosuppressive. In this study, we report an adult who admitted to our hospital due to fever and gross hematuria. The patient presented with nephritic syndrome and renal failure and confirmed to have M. pneumoniae infection by serum detection and acute postinfectious glomerulonephritis with a large number of crescents by renal biopsy...
July 2015: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/26258874/interventions-for-preventing-and-treating-kidney-disease-in-henoch-sch%C3%A3-nlein-purpura-hsp
#18
REVIEW
Deirdre Hahn, Elisabeth M Hodson, Narelle S Willis, Jonathan C Craig
BACKGROUND: Henoch-Schönlein purpura (HSP) is the most common vasculitis of childhood but may occur in adults. This small vessel vasculitis is characterised by palpable purpura, abdominal pain, arthritis or arthralgia and kidney involvement. This is an update of a review first published in 2009. OBJECTIVES: To evaluate the benefits and harms of different agents (used singularly or in combination) compared with placebo, no treatment or any other agent for: (1) the prevention of severe kidney disease in patients with HSP without kidney disease at presentation; (2) the prevention of severe kidney disease in patients with HSP and minor kidney disease (microscopic haematuria, mild proteinuria) at presentation; (3) the treatment of established severe kidney disease (macroscopic haematuria, proteinuria, nephritic syndrome, nephrotic syndrome with or without acute kidney failure) in HSP; and (4) the prevention of recurrent episodes of HSP-associated kidney disease...
August 7, 2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26221341/serum-galactose-deficient-iga1-levels-in-children-with-iga-nephropathy
#19
Mengjie Jiang, Xiaoyun Jiang, Liping Rong, Yuanyuan Xu, Lizhi Chen, Zeting Qiu, Ying Mo
Immunoglobulin A nephropathy (IgAN) is an immunopathologic diagnosis based on a renal biopsy, it is characterized by deposits of IgA-containing immune complexes in the mesangium. Adults with IgAN have a galactose-deficient IgA1 in the circulation and glomerular deposition. There are few studies on the glycosylation of serum IgA1 in children with IgAN. To measure the serum levels of galactose-deficient IgA1 in pediatric patients with IgAN, 72 biopsy-proven IgAN children were divided into 3 groups based on the clinical features: isolated hematuria group (24 patients), hematuria and proteinuria group (22 patients), and nephritic syndrome group (26 patients)...
2015: International Journal of Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/26178570/pattern-of-glomerular-disease-in-nepal-a-single-center-experience
#20
S Khakurel, R K Agrawal, R Hada
Glomerulonephritis (GN) is the most common cause of end-stage renal disease in Nepal. The aim of the present study is to determine the clinical presentation and histological pattern of GN with and without immunofluorescence (IF). It is a retrospective analysis of all GN patients with kidney biopsy at the Bir Hospital from January 2000 to April 2009. The clinical presentation, blood pressure, urine analysis, 24-h urinary protein, biochemistry, hemoglobin, antinuclear antibody, anti-ds DNA, light microscopy (LM) and IF findings of kidney biopsies were computed from hospital records...
July 2015: Saudi Journal of Kidney Diseases and Transplantation
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