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https://www.readbyqxmd.com/read/29219858/the-precision-of-ecap-thresholds-derived-from-amplitude-growth-functions
#1
Jan Dirk Biesheuvel, Jeroen J Briaire, Johan H M Frijns
OBJECTIVE: An amplitude growth function (AGF) shows the amplitude of an electrically evoked compound action potential (eCAP) as a function of the stimulation current. AGFs can be used to derive the eCAP threshold, which represents the minimum amount of current needed to elicit a measurable eCAP. eCAP thresholds have been widely used clinically to, for example, assist with sound processor programming. However, no eCAP precision has been included to date. The aim of this study was to investigate the precision of eCAP thresholds and determine whether they are precise enough for clinical use...
December 6, 2017: Ear and Hearing
https://www.readbyqxmd.com/read/29212624/clinical-indices-can-standardize-and-monitor-pediatric-care-a-novel-mechanism-to-improve-quality-and-safety
#2
Wallace Crandall, J Terrance Davis, Jennifer Dotson, Charles Elmaraghy, Mike Fetzer, Don Hayes, Edwin Horwitz, Amy Kogon, Randal Olshefski, Hiren Patel, Richard J Brilli
OBJECTIVE: The Cancer Care Index (CCI), a single metric that sums the number of undesirable patient events in a given time frame (either preventable harm events or missed opportunities to provide optimal care), resulted in a 42% improvement in performance. Our objective was to test the index concept in other service lines to determine whether similar performance improvement occurred. STUDY DESIGN: Care indices were developed and introduced in 3 additional service lines: Nephrology (Chronic Kidney Disease Care Index; CKDCI), Pulmonology (Lung Transplantation Care Index; LTCI), and Otolaryngology (Tracheostomy Care Index; TCI)...
December 4, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29210352/congenital-transmission-of-trypanosoma-cruzi-in-argentina-honduras-and-mexico-an-observational-prospective-study
#3
Pierre Buekens, Maria-Luisa Cafferata, Jackeline Alger, Fernando Althabe, Jose M Belizan, Norma Bustamante, Yves Carlier, Alvaro Ciganda, Jaime H DelCid, Eric Dumonteil, Rubi Gamboa-León, Jorge A García, Luz Gibbons, Olga Graiff, Jesus Gurubel Maldonado, Claudia Herrera, Elizabeth Howard, Laura Susana Lara, Benjamín López, Maria Luisa Matute, María Jesús Ramírez-Sierra, María Cecilia Robles, Sergio Sosa-Estani, Carine Truyens, Christian Valladares, Dawn M Wesson, Concepcion Zuniga, For The Congenital Chagas Working Group
Compared with South America, there is a lack of epidemiologic studies about the risk of congenital transmission of Trypanosoma cruzi in Central America and Mexico. It has been suggested that T. cruzi genotypes might differ by region and that congenital transmission might vary according to the parasite's genotype. Our objective was to compare T. cruzi congenital transmission rates in three countries. We performed an observational prospective study in 2011-2014 enrolling women at delivery in one hospital in Argentina, two hospitals in Honduras, and two hospitals in Mexico...
December 4, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29182646/transcriptome-wide-analysis-of-the-trypanosoma-cruzi-proliferative-cycle-identifies-the-periodically-expressed-mrnas-and-their-multiple-levels-of-control
#4
Santiago Chávez, Guillermo Eastman, Pablo Smircich, Lorena Lourdes Becco, Carolina Oliveira-Rizzo, Rafael Fort, Mariana Potenza, Beatriz Garat, José Roberto Sotelo-Silveira, María Ana Duhagon
Trypanosoma cruzi is the protozoan parasite causing American trypanosomiasis or Chagas disease, a neglected parasitosis with important human health impact in Latin America. The efficacy of current therapy is limited, and its toxicity is high. Since parasite proliferation is a fundamental target for rational drug design, we sought to progress into its understanding by applying a genome-wide approach. Treating a TcI linage strain with hydroxyurea, we isolated epimastigotes in late G1, S and G2/M cell cycle stages at 70% purity...
2017: PloS One
https://www.readbyqxmd.com/read/29176770/high-trypanosoma-spp-diversity-is-maintained-by-bats-and-triatomines-in-esp%C3%A3-rito-santo-state-brazil
#5
Maria Augusta Dario, Cristiane Varella Lisboa, Luciana M Costa, Ricardo Moratelli, Monique Pereira Nascimento, Leonora Pires Costa, Yuri Luiz Reis Leite, Martin S Llewellyn, Samanta Cristina das Chagas Xavier, André Luiz Rodrigues Roque, Ana Maria Jansen
The aim of this study was to reevaluate the ecology of an area in the Atlantic Forest, southeast Brazil, where Chagas disease (CD) has been found to occur. In a previous study, immediately after the occurrence of a CD case, we did not observe any sylvatic small mammals or dogs with Trypanosoma cruzi cruzi infections, but Triatoma vitticeps presented high T. c. cruzi infection rates. In this study, we investigated bats together with non-volant mammals, dogs, and triatomines to explore other possible T. c. cruzi reservoirs/hosts in the area...
2017: PloS One
https://www.readbyqxmd.com/read/29163234/a-comparison-of-treatment-seeking-behavioral-addiction-patients-with-and-without-parkinson-s-disease
#6
Anne Sauvaget, Susana Jiménez-Murcia, Fernando Fernández-Aranda, Roser Granero, Marie Grall-Bronnec, Caroline Victorri-Vigneau, Samuel Bulteau, Pascal Derkinderen, Jean M Vanelle, Anders Hakansson, Gemma Mestre-Bach, Trevor Steward, José M Menchón
The administration of dopaminergic medication to treat the symptoms of Parkinson's disease (PD) is associated with addictive behaviors and impulse control disorders. Little is known, however, on how PD patients differ from other patients seeking treatments for behavioral addictions. The aim of this study was to compare the characteristics of behavioral addiction patients with and without PD. N = 2,460 treatment-seeking men diagnosed with a behavioral addiction were recruited from a university hospital. Sociodemographic, impulsivity [Barratt Impulsiveness Scale (BIS-11)], and personality [Temperament and Character Inventory-Revised (TCI-R)] measures were taken upon admission to outpatient treatment...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29161488/identifying-trypanosoma-cruzi-discreet-typing-units-in-triatomines-collected-in-different-natural-regions-of-per%C3%A3%C2%BA
#7
Carlos P Padilla, Uriel Alvarado, Gladis Ventura, Deysi Luna-Caipo, Marcial Suárez, José R Tuñoque, Nancy Ruelas-Llerena, Luis A Fachín, Alina Huiza, Lizandro Gonzáles, Julio César Carranza, Gustavo Adolfo Vallejo, Gustavo Adolfo Vallejo, Abraham G Cáceres, Abraham G Cáceres
INTRODUCTION: Trypanosoma cruzi has been divided by international consensus into six discrete typing units (DTU): TcI, TcII, TcIII, TcIV, TcV y TcVI. The factors determining the dynamics of T. cruzi genotypes vector transmission of Chagas' disease in the different geographical regions of Perú are still unknown. OBJECTIVE: To detect and type T. cruzi DTUs from the faeces of seven species of triatomines (Panstrongylus chinai, P. geniculatus, P. herreri, Rhodnius robustus, R...
March 29, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/29144219/trypanosoma-sp-diversity-in-amazonian-bats-chiroptera-mammalia-from-acre-state-brazil
#8
Francisco C B Dos Santos, Cristiane V Lisboa, Samanta C C Xavier, Maria A Dario, Rair de S Verde, Armando M Calouro, André Luiz R Roque, Ana M Jansen
Bats are ancient hosts of Trypanosoma species and their flying ability, longevity and adaptability to distinct environments indicate that they are efficient dispersers of parasites. Bats from Acre state (Amazon Biome) were collected in four expeditions conducted in an urban forest (Parque Zoobotânico) and one relatively more preserved area (Seringal Cahoeira) in Rio Branco and Xapuri municipalities. Trypanosoma sp. infection was detected by hemoculture and fresh blood examination. Isolated parasite species were identified by the similarity of the obtained DNA sequence from 18S rDNA polymerase chain reaction and reference strains...
November 16, 2017: Parasitology
https://www.readbyqxmd.com/read/29129867/a-non-invasive-monitoring-of-propofol-concentration-in-blood-by-a-virtual-surface-acoustic-wave-sensor-array
#9
Fengjiang Zhang, Hao Dong, Xuanlang Zhang, Jin Guo, Yunqing Liu, Cheng Zhou, Xi Zhang, Jun Liu, Min Yan, Xing Chen
Propofol (2,6-diisopropylphenol) is widely used in total intravenous anesthesia. An unknown drug concentration in blood always leads to some side effects in patients with propofol injection. However, the drug concentration in the blood is hard to be continuously measured since invasive sampling causes a loss of blood at each measurement. Here, we introduced a virtual surface acoustic wave sensor array (VSAWSA) to non-invasively detect the propofol concentration in blood through exhaled gases. Calibration was conducted by a parallel test using gas chromatography and mass spectrometry (GC-MS) with solid-phase micro-extraction (SPME) for preconcentration...
2017: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/29113781/the-effect-of-reinfection-and-mixed-trypanosoma-cruzi-infections-on-disease-progression-in-mice
#10
Catherine J Perez, R C Andrew Thompson, Sarah K Keatley, Audra L Walsh, Alan J Lymbery
The progression of Chagas disease (CD) varies significantly from host to host and is affected by multiple factors. In particular, mixed strain infections and reinfections have the potential to exacerbate disease progression subsequently affecting clinical management of patients with CD. Consequently, an associated reduction in therapeutic intervention and poor prognosis may occur due to this exacerbated disease state. This study investigated the effects of mixed strain infections and reinfection with Trypanosoma cruzi in mice, using two isolates from different discrete typing units, TcI (C8 clone 1) and TcIV (10R26)...
November 4, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29110350/fertilizing-ability-of-canine-spermatozoa-cryopreserved-with-skim-milk-based-extender-in-a-retrospective-study
#11
Y Abe, S Yokozawa, R Umemiya-Shirafuji, Pfa Moumouni, Y Suwa, H Suzuki
We previously reported that skim milk (SM) is an effective cryoprotectant for cryopreservation of canine spermatozoa instead of egg yolk (EY), which is the conventional cryoprotectant. In this study, the fertilizing ability and practical use of frozen canine spermatozoa prepared with SM were evaluated by transcervical insemination. Frozen-thawed spermatozoa were inseminated one to four times on days 2-9 after the LH surge. In SM group, a single transcervical insemination (TCI) on Day 5 led to higher delivery rate (83%) than any other days (33%-50%) post-LH surge...
November 7, 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/29104660/target-controlled-infusion-of-propofol-and-remifentanil-combined-with-dexmedetomidine-reduces-functional-endoscopic-sinus-surgery-bleeding
#12
Deng-Feng Ding, Li-Fang Wu, Ping Wang, Yuan-Xu Jiang, Yao-Wen Luo, Zhong-Liang Dai, Xue-Ping Zhang, Ya-Li Li
The aim of the present study was to investigate the effects of target-controlled infusion (TCI) of propofol and remifentanil combined with dexmedetomidine on functional endoscopic sinus surgery (FESS) bleeding and surgical field. 62 patients scheduled to undergo FESS were randomly divided into experimental group (intravenous 0.5 µg kg-1 h-1 dexmedetomidine after 0.5 µg kg-1 bolus within 15 min until the end of surgery) or control group (intravenous saline administration at the same dose). All patients underwent endotracheal intubation under general anesthesia with TCI of propofol and remifentanil for anesthesia induction and maintenance...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29102897/the-hypothalamic-pituitary-thyroid-axis-and-personality-in-a-sample-of-healthy-subjects
#13
Aleksei Piskunov, Adela Fusté, Nadezhda Teryaeva, Aleksei Moshkin, José Ruiz
Thyroid hormones influence various brain pathologies, including psychiatric disorders. However, the relationship between these hormones and the psychological state in the normal, non-clinical population is poorly understood. We aimed to test whether serum levels of thyroid hormones are associated with personality in the healthy population. Thyrotropin (TSH), free T3 (FT4), total and free T4 (TT4 and FT4) concentrations were measured in the blood of 104 healthy participants (44% men) aged 18-59 (M=35±9). Personality traits were assessed using the revised short versions of the Temperament and Character Inventory (TCI-140) and the NEO Five-Factor Inventory (NEO-FFI)...
October 31, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29100975/personality-measures-after-gamma-ventral-capsulotomy-in-intractable-ocd
#14
Raquel R Paiva, Marcelo C Batistuzzo, Nicole C McLaughlin, Miguel M Canteras, Maria E de Mathis, Guaraci Requena, Roseli G Shavitt, Benjamin D Greenberg, Georg Norén, Steven A Rasmussen, Hermano Tavares, Eurípedes C Miguel, Antonio C Lopes, Marcelo Q Hoexter
BACKGROUND: Neurosurgeries such as gamma ventral capsulotomy (GVC) are an option for otherwise intractable obsessive-compulsive disorder (OCD) patients. In general, clinical and neuropsychological status both improve after GVC. However, its consequences on personality traits are not well-studied. The objective of this study was to investigate personality changes after one year of GVC in intractable OCD patients. METHODS: The personality assessment was conducted using the Revised NEO Personality Inventory (NEO PI-R) and Cloninger's Temperament and Character Inventory (TCI) in 14 intractable OCD patients before and one year after GVC...
November 1, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29092782/psychopathological-constellation-in-patients-with-pnes-a-new-hypothesis
#15
Iolanda Martino, Antonella Bruni, Angelo Labate, Roberta Vasta, Antonio Cerasa, Giuseppe Borzì, Pasquale De Fazio, Antonio Gambardella
Depression symptoms have often reported in patients with psychogenic nonepileptic seizures (PNES), although the underlying psychopathological symptomatology has been poorly understood. Our aim was to compare constellations of psychological and behavioral disturbance in PNES with respect to patients with mild-major depressive disorder (MDD), hypothesizing that the construct of depression might be different in the two groups. Ten patients with PNES and ten sex-/age-matched patients with mild-MDD newly-diagnosed, were enrolled in this study...
October 29, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29080410/temperament-and-character-in-patients-with-systemic-lupus-erythematosus
#16
Arash Mani, Anahita Rostami, Elham Aflaki, Parsa Ravanfar
BACKGROUND: In addition to identified neuropsychiatric characteristic of systemic lupus erythematosus (SLE), changes in personality seem to occur in patients with SLE. Even in absence of an axis I psychiatric diagnosis, personality variations play important role in general wellbeing of these patients. This study investigated personality features in patients with SLE using Temperament and Character Inventory (TCI). METHOD: In this case-control study personality features of 59 patients with confirmed diagnosis of SLE were evaluated using Persian version of TCI-125 questionnaire...
September 19, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29079540/il-18-contributes-to-bone-cancer-pain-by-regulating-glia-cells-and-neuron-interaction
#17
Su Liu, Yue-Peng Liu, You Lv, Jun-Li Yao, Dong-Mei Yue, Mao-Yin Zhang, Dun-Yi Qi, Gong-Jian Liu
BACKGROUND: Glia cells hyperactivity has been proposed to be responsible for chronic pain, however, the mechanisms remain unclear. IL-18, released from glial cells, has been reported to be involved in neuropathic pain. Here, we investigated the role of IL-18 in bone cancer pain. METHODS: Bone cancer pain was mimicked by injecting Walker-256 mammary gland carcinoma cells into the intramedullary space of the tibia in rats. Expression and location of IL-18 and IL-18 receptor were tested...
October 24, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29053126/-effect-of-cytokine-genes-and-season-of-birth-on-personality
#18
M V Alfimova, V E Golimbet, G I Korovaitseva, T V Lezheiko, N V Kondrat'ev, M V Gabaeva
AIM: To evaluate the interaction effects of season of birth and immune system genes on the personality traits 'Novelty seeking' (NS) and 'Self-directedness' (SD). Based on results on an influence of the immune system on the brain processes, the authors hypothesized that the interaction of immune system genes and season of birth, which is relevant for immune phenotype, can contribute to the development of personality traits. MATERIAL AND METHODS: NS and SD were measured in 336 healthy volunteers, aged from 16 to 67 years, using the Temperament and Character Inventory (TCI-125)...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29042895/no-association-between-the-polymorphism-rs6943555-in-the-auts2-gene-and-personality-traits-in-japanese-university-students
#19
Shin Narita, Kazutaka Ikeda, Daisuke Nishizawa, Eiji Yoshihara, Maki Numajiri, Yuuya Onozawa, Nobuyo Ohtani, Kazuhiko Iwahashi
OBJECTIVE: The autism susceptibility candidate 2 (AUTS2) gene has been implicated in multiple neurological disorders. Several recent studies have revealed that the polymorphism rs6943555 in the AUTS2 gene is broadly associated with human mental function and behavior. Therefore, in the present study we investigated whether the polymorphism rs6943555 is associated with human personality traits in Japanese university students. In addition, our previous study reported that the AUTS2 rs6943555-rs9886351 haplotype is associated with alcohol dependence...
September 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/29040847/characterization-of-ionic-liquid-pretreated-plant-cell-wall-for-improved-enzymatic-digestibility
#20
Tirath Raj, Ruchi Gaur, Bhawna Yadav Lamba, Nitu Singh, Ravi P Gupta, Ravindra Kumar, Suresh K Puri, S S V Ramakumar
An insight into the properties of cell wall of mustard stalk (MS) pretreated by five ionic liquids (ILs) revealed ILs interaction with cellulose, hemicellulose and lignin components. Differential Scanning Calorimetry (DSC) showed increased pore size coupled with increased population of pores evoked by certain ILs in better facilitating enzymatic accessibility. Interestingly, all the five ILs predominantly increased the propensity of two pore sizes formation; 19 and 198 nm, but remarkable difference in the pore volumes of pretreated MS suggested the supremacy of [OAc](-) based ILs, resulting in higher glucose yields...
October 4, 2017: Bioresource Technology
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