Read by QxMD icon Read


Ana Maria Jansen, Samanta Cristina das Chagas Xavier, André Luiz Rodrigues Roque
Trypanosoma cruzi (Kinetoplastea: Trypanosomatidae) infects all tissues of its hosts, which along with humans, include hundreds of mammalian species in the Americas. The epidemiology of T. cruzi has been changing in that currently the majority of the cases and/or outbreaks of Chagas disease occur by the ingestion of comestibles contaminated by T. cruzi metacyclic forms. These cases/outbreaks occur in distinct regional scenarios, mainly in the Amazon biome and are related to the local interaction mode of humans with their surroundings, as well as with the overall local ecological peculiarities...
September 6, 2018: Parasites & Vectors
Chieh-Wen Liu, Feng Wei, Kasun Premasiri, Shuhao Liu, Song Ma, Zhidong Zhang, Xuan P A Gao
The Drude model is one of the most fundamental models used to understand the electronic carrier transport in materials, including recently discovered topological materials. Here, we present a magneto-transport study revealing the non-Drude transport behavior in a heterostructure of topological crystalline insulator (TCI) SnTe and band insulator PbTe which exhibits a non-saturating linear magneto-resistance (MR) effect, a novel phenomenon widely observed in topological materials with gapless dispersion. It is shown that in the van der Pauw geometry in which the longitudinal and transverse magneto-resistances are measured to extract the magneto-conductivity, the two-band Drude model is not sufficient to self-consistently describe both the longitudinal and transverse magneto-conductivities...
September 5, 2018: Nano Letters
Luz P Quebrada Palacio, Mariela N González, Yolanda Hernandez-Vasquez, Alina E Perrone, Adriana Parodi-Talice, Jacqueline Bua, Miriam Postan
Trypanosoma cruzi is a genetically heterogeneous group of organisms that cause Chagas disease. It has been long suspected that the clinical outcome of the disease and response to therapeutic agents are, at least in part, related to the genetic characteristics of the parasite. Herein, we sought to validate the significance of the genotype of T. cruzi isolates recovered from patients with different clinical forms of Chagas disease living in Argentina on their biological behaviour and susceptibility to drugs. Genotype identification of the newly established isolates confirmed the reported predominance of TcV, with a minor frequency of TcI...
2018: PloS One
Yang Luo, Hong-Xin Cui, An Jia, Shan-Shan Jia, Ke Yuan
Abelmoschus esculentus L. has favorable nutritional/medicinal features. We found the content of total flavonoids in flower extract to be the highest (788.56 mg/g) of all the different parts of A. esculentus ; according to high-performance liquid chromatography, the quercetin-3-O-[ β -D-glu-(1 → 6)]- β -D-glucopyranoside content was 122.13 mg/g. Protective effects of an extract of the total flavonoids of A. esculentus flowers (AFF) on transient cerebral ischemia-reperfusion injury (TCI-RI) were investigated...
2018: Oxidative Medicine and Cellular Longevity
Ida Tylleskar, Arne Kristian Skulberg, Sissel Skarra, Turid Nilsen, Ola Dale
PURPOSE: Pharmacodynamic studies of naloxone require opioid agonism. Steady state condition may be achieved by remifentanil TCI (target controlled infusion). Opioid agonism can be measured by pupillometry. It is not known whether there are arteriovenous concentration differences for naloxone. The aim was thus to further develop a model for studying pharmacokinetic/pharmacodynamic aspects of naloxone and to explore whether a significant arteriovenous concentration difference for naloxone in humans was present...
August 24, 2018: European Journal of Clinical Pharmacology
Andréa Pereira da Costa, Juliana Isabel Giuli da Silva Ferreira, Ryan Emiliano da Silva, Renata Tonhosolo, Andreina de Carvalho Araújo, Maíra Freitas Guimarães, Mauricio Cláudio Horta, Marcelo Bahia Labruna, Arlei Marcili
INTRODUCTION: The National Park of Serra das Confusões (NPSC) is a protected area of natural landscape located in Southern Piauí, Brazil, and it is considered as one of the largest and most important protected areas in the Caatinga biome. METHODS: The natural occurrences of trypanosomatids from hemocultures on small mammals and cultures from intestinal contents triatomines were detected through molecular diagnoses of blood samples, and phylogenetic relationship analysis of the isolates parasites using the trypanosome barcode (V7V8 SSUrDNA) were realized...
July 2018: Revista da Sociedade Brasileira de Medicina Tropical
David Miller, Sharon R Lewis, Michael W Pritchard, Oliver J Schofield-Robinson, Cliff L Shelton, Phil Alderson, Andrew F Smith
BACKGROUND: The use of anaesthetics in the elderly surgical population (more than 60 years of age) is increasing. Postoperative delirium, an acute condition characterized by reduced awareness of the environment and a disturbance in attention, typically occurs between 24 and 72 hours after surgery and can affect up to 60% of elderly surgical patients. Postoperative cognitive dysfunction (POCD) is a new-onset of cognitive impairment which may persist for weeks or months after surgery.Traditionally, surgical anaesthesia has been maintained with inhalational agents...
August 21, 2018: Cochrane Database of Systematic Reviews
Jie Yang, Wenzhi Yu, Zhenghui Pan, Qiang Yu, Qing Yin, Lei Guo, Yanfei Zhao, Tian Sun, Qiaoliang Bao, Kai Zhang
Topological crystalline insulators (TCIs) are predicted to be a promising candidate material for ultra-broadband photodetectors ranging from ultraviolet (UV) to terahertz (THz) due to its gapless surface state and narrow bulk bandgap. However, the low responsivity of TCIs-based photodetectors limits their further applications. In this regard, a high-performance photodetector based on SnTe, a recently developed TCI, working in a broadband wavelength range from deep UV to mid-IR with high responsivity is reported...
August 20, 2018: Small
Michael D Celestin, Tekeda Ferguson, Edward C Ledford, Tung-Sung Tseng, Thomas Carton, Sarah Moody-Thomas
The Louisiana Tobacco Control Initiative (TCI), a multidisciplinary program specializing in helping tobacco users quit, assisted health care providers in Louisiana's public hospitals with integrating evidence-based treatment of tobacco use into clinical practice. Our study compared smoking behavior, provider adherence to the 5 A's tobacco cessation intervention (ask, advise, assess, assist, and arrange), cessation assistance awareness, quit attempts, and treatment preference among respondents to a TCI survey with a sample of respondents from the National Adult Tobacco Survey (NATS) and a sample from the Louisiana Adult Tobacco Survey (LATS)...
August 16, 2018: Preventing Chronic Disease
Ernest Awoonor-Williams, Christopher N Rowley
Targeted covalent inhibitors (TCIs) have been successfully developed as high-affinity and selective inhibitors of enzymes of the protein kinase family. These drugs typically act by undergoing an electrophilic addition with an active-site cysteine residue, so design of a TCI begins with the identification of a "druggable" cysteine. These electrophilic additions generally require deprotonation of the thiol to form a reactive anionic thiolate, so the acidity of the residue is a critical factor. Few experimental measurements of the p Ka 's of druggable cysteines have been reported, so computational prediction could prove to be very important in selecting reactive cysteine targets...
August 29, 2018: Journal of Chemical Information and Modeling
Laura D Tamayo, Felipe Guhl, Gustavo A Vallejo, Juan David Ramírez
The increase in the global land temperature, expected under predictions of climate change, can directly affect the transmission of some infectious diseases, including Chagas disease, an anthropozoonosis caused by Trypanosoma cruzi and transmitted by arthropod vectors of the subfamily Triatominae. This work seeks to study the effects of temperature on the development of the life cycle, fertility and fecundity of the insect vector Rhodnius prolixus and on the metacyclogenesis of T. cruzi. All of the variables were subjected to 3 temperatures: 26°C, 28°C and 30°C...
August 2018: PLoS Neglected Tropical Diseases
Jelena M Mašković, Antonios Hatzidimitriou, Ana Damjanović, Tatjana P Stanojković, Srećko R Trifunović, Athina A Geronikaki, Dionysia Papagiannopoulou
A new thiazole-containing multidentate ligand 2-((2-phenylthiazol-4-yl)methylthio)ethanamine, L, was synthesized and used to prepare new complexes of the formula PdII LCl2 (Pd-L), CuII L2 Cl2 (Cu-L) and fac -[Re/99m TcI (CO)3 (L)]+ (Re/99m Tc-L). The ligand L and the metal complexes were characterized spectroscopically. Furthermore, the structures of Re-L and Cu-L were elucidated by X-ray crystallography. Ligand L acts as a bidentate (Nth , S) chelator in Pd-L, as a bidentate (N, S) chelator in Cu-L and as a tridentate (Nth , S, N) chelator in Re-L...
May 1, 2018: MedChemComm
Andreas Irmler, Asbjörn M Burow, Fabian Pauly
In this work, we present a robust implementation of the periodic Fock exchange for atom-centered Gaussian-type orbitals (GTOs). We discuss the divergence, appearing in the formulation of the periodic Fock exchange in the case of a finite number of k-points, and compare two schemes that remove it. These are the minimum image convention (MIC) and the truncated Coulomb interaction (TCI) that we use here in combination with k-meshes. We observe artifacts in four-center integrals of GTOs, when evaluated in the TCI scheme...
September 11, 2018: Journal of Chemical Theory and Computation
Marek Havlík, Karolína Mladá, Iveta Fajnerová, Jiří Horáček
The elusive relationship between the mental domain and the physical brain, known as the mind-body problem, is still a hot topic of discussion among philosophers and neuroscientists. Rather than solving this problem, our pilot study addresses the question as to whether personality features could influence intuitions of the mind-body problem, or more precisely, whether it is possible to identify a person's intuitive inclinations toward dualism or materialism and their inclinations toward reduction of the mind to the brain...
2018: Frontiers in Psychology
Emilie Katrine Kongebro, Lars N Jorgensen, Volkert D Siersma, Christian Sahlholt Meyhoff
BACKGROUND: Perioperative hyperoxia has been linked to increased long-term mortality. Vasoconstrictive and cellular side effects to hyperoxia have been suggested to increase the risk of coronary and cerebral ischemia. The aim of this post-hoc analysis of a large randomized trial was to compare the effects of 80% vs 30% perioperative oxygen on the long-term risk of stroke or transient cerebral ischemia (TCI) in patients undergoing abdominal surgery. METHODS: A total of 1386 patients were randomized to 80% or 30% perioperative oxygen during acute or elective open abdominal surgery...
July 31, 2018: Acta Anaesthesiologica Scandinavica
Daniel Vladimirov, Solja Niemelä, Sirkka Keinänen-Kiukaanniemi, Leena Ala-Mursula, Juha Auvinen, Markku Timonen, Jouko Miettunen
BACKGROUND: Temperament is theorized to be an important factor contributing to the development of alcohol use disorder, but longitudinal studies on how temperament is related to alcohol use among general population in midlife are scarce. Our aims were to investigate potentially reciprocal associations between temperament and changes in alcohol use from age 31 to 46 using prospective birth cohort data. METHOD: Within the Northern Finland Birth Cohort 1966, alcohol use and temperament were studied at ages 31 and 46...
July 31, 2018: Alcoholism, Clinical and Experimental Research
Stefano Porcelli, Agnese Marsano, Elisabetta Caletti, Michela Sala, Vera Abbiati, Marcella Bellani, Cinzia Perlini, Maria Gloria Rossetti, Gian Mario Mandolini, Alessandro Pigoni, Riccardo Augusto Paoli, Sara Piccin, Matteo Lazzaretti, Dora Fabbro, Giuseppe Damante, Carolina Bonivento, Clarissa Ferrari, Roberta Rossi, Laura Pedrini, Alessandro Serretti, Paolo Brambilla
BACKGROUND: Bipolar disorder (BD) has been associated with temperamental and personality traits, although the relationship is still to be fully elucidated. Several studies investigated the genetic basis of temperament and character, identifying catechol-O-methyltransferase (COMT), brain derived neurotrophic factor (BDNF), and serotonin transporter (5-HTT) gene variants as strong candidates. METHODS: In the GECO-BIP study, 125 BD patients and 173 HC were recruited...
2017: Neuropsychobiology
Shu-Ping Chen, Jia Sun, Ya-Qun Zhou, Fei Cao, Cody Braun, Fang Luo, Da-Wei Ye, Yu-Ke Tian
Cancer-induced bone pain is one of the most severe types of pathological pain, which often occurs in patients with advanced prostate, breast, and lung cancer. It is of great significance to improve the therapies of cancer-induced bone pain due to the opioids' side effects including addiction, sedation, pruritus, and vomiting. Sinomenine, a traditional Chinese medicine, showed obvious analgesic effects on a rat model of chronic inflammatory pain, but has never been proven to treat cancer-induced bone pain. In the present study, we investigated the analgesic effect of sinomenine after tumor cell implantation and specific cellular mechanisms in cancer-induced bone pain...
January 2018: Molecular Pain
Nobuyuki Mitsui, Satoshi Asakura, Keisuke Takanobu, Shinya Watanabe, Kuniyoshi Toyoshima, Yuki Kako, Yoichi M Ito, Ichiro Kusumi
BACKGROUND: Suicide has been a leading cause of death among young adult populations in Japan. The aim of this study was to predict major depressive episodes (MDEs) and suicide-related ideation among university students using the Patient Health Questionnaire-9 (PHQ-9) and the Temperament and Character Inventory (TCI). METHODS: The subjects were 2194 university students who completed the PHQ-9 and TCI in the 1st year (T1) and the PHQ-9 in the 4th year (T2) of university...
2018: PloS One
Azael Saldaña, Ana María Santamaría, Vanessa Pineda, Vanessa Vásquez, Nicole L Gottdenker, José E Calzada
BACKGROUND: Rhodnius pallescens, the only species of this genus reported in Panama, has a wide geographical distribution and is associated with most cases of Chagas disease and human infections with Trypanosoma rangeli in this country. Thus far, no phenotypic variants of this triatomine have been registered. Similarly, genotyping of the trypanosomes that infect this vector has only been partially evaluated. RESULTS: A total of 347 specimens of R. pallescens were collected in Attalea butyracea palm trees located near a mountainous community of the district of Santa Fe, province of Veraguas...
July 16, 2018: Parasites & Vectors
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"