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https://www.readbyqxmd.com/read/29028925/influence-of-bayesian-optimization-on-the-performance-of-propofol-target-controlled-infusion
#1
J P van den Berg, D J Eleveld, T De Smet, A V M van den Heerik, K van Amsterdam, B J Lichtenbelt, T W L Scheeren, A R Absalom, M M R F Struys
Background: Target controlled infusion (TCI) systems use population-based pharmacokinetic (PK) models that do not take into account inter-individual residual variation. This study compares the bias and inaccuracy of a population-based vs a personalized TCI propofol titration using Bayesian adaptation. Haemodynamic and hypnotic stability, and the prediction probability of alternative PK models, was studied. Methods: A double-blinded, prospective randomized controlled trial of 120 subjects undergoing cardiac surgery was conducted...
October 3, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28988995/overcoming-or-circumventing-the-stratum-corneum-barrier-for-efficient-transcutaneous-immunization
#2
REVIEW
Zhongjian Chen, Yongjiu Lu, Jianping Qi, Quangang Zhu, Yi Lu, Wei Wu
Transcutaneous immunization (TCI) is a promising alternative to vaccine delivery via the subcutaneous and intramuscular routes because of the unique immunological characteristics of the skin. However, the stratum corneum (SC) prevents entry of most therapeutic compounds into the body. Several physical devices have been developed to overcome the SC barrier, but still damage the skin. However, by targeting antigens to the abundant perifollicular antigen-presenting cells (APCs), the transfollicular route might be a promising approach for TCI without compromising the skin barrier...
October 5, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/28977097/temperament-and-character-traits-in-major-depressive-disorder-a-case-control-study
#3
Barbara Schwair Nogueira, Renerio Fraguas, Isabela Martins Benseñor, Paulo Andrade Lotufo, Andre Russowsky Brunoni
BACKGROUND: Patients with major depressive disorder (MDD) have distinct personality traits, compared with control subjects, although the role of anxiety and positive and negative affects in this finding is unclear. DESIGN AND SETTING: A case-control study enrolling 103 antidepressant-free depressed patients and 103 age and gender-matched controls was conducted at the University Hospital, University of São Paulo. METHODS: The self-reported scales of the Positive and Negative Affect Schedule (PANAS), State-Trait Anxiety Inventory (STAI) and Cloninger's Temperament and Character Inventory (TCI) were applied...
October 2, 2017: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/28957315/the-diversity-of-the-chagas-parasite-trypanosoma-cruzi-infecting-the-main-central-american-vector-triatoma-dimidiata-from-mexico-to-colombia
#4
Patricia L Dorn, Annie G McClure, Meghan D Gallaspy, Etienne Waleckx, Adrienne S Woods, Maria Carlota Monroy, Lori Stevens
Little is known about the strains of Trypanosoma cruzi circulating in Central America and specifically in the most important vector in this region, Triatoma dimidiata. Approximately six million people are infected with T. cruzi, the causative agent of Chagas disease, which has the greatest negative economic impact and is responsible for ~12,000 deaths annually in Latin America. By international consensus, strains of T. cruzi are divided into six monophyletic clades called discrete typing units (DTUs TcI-VI) and a seventh DTU first identified in bats called TcBat...
September 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28941731/trypanosoma-cruzi-genetic-diversity-something-new-for-something-known-about-chagas-disease-manifestations-serodiagnosis-and-drug-sensitivity
#5
REVIEW
Bianca Zingales
The genetic diversity of Trypanosoma cruzi, the protozoan agent of Chagas disease, is widely recognized. At present, T. cruzi is partitioned into seven discrete typing units (DTUs), TcI-TcVI and Tcbat. This article reviews the present knowledge on the parasite population structure, the evolutionary relationships among DTUs and their distinct, but not exclusive ecological and epidemiological associations. Different models for the origin of hybrid DTUs are examined, which agree that genetic exchange among T. cruzi populations is frequent and has contributed to the present parasite population structure...
September 20, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28919665/hurricane-imaging-radiometer-hirad-wind-speed-retrievals-and-validation-using-dropsondes
#6
Daniel J Cecil, Sayak K Biswas
Surface wind speed retrievals have been generated and evaluated using Hurricane Imaging Radiometer (HIRAD) measurements from flights over Hurricane Joaquin, Hurricane Patricia, Hurricane Marty, and the remnants of Tropical Storm Erika, all in 2015. Procedures are described here for producing maps of brightness temperature, which are subsequently used for retrievals of surface wind speed and rain rate across a ~50 km wide swath for each flight leg. An iterative retrieval approach has been developed to take advantage of HIRAD's measurement characteristics...
August 2017: J Atmos Ocean Technol
https://www.readbyqxmd.com/read/28886612/-remifentanil-up2date-part-2
#7
Stefan Bushuven, Sascha Kreuer, Peter Kranke
Remifentanil is a short-acting opioid of high analgetic potency and superior controllability. It is widely used in day-case surgery, procedural sedation, for reduction of recovery-times and obstetrics and whenever excellent controllability of opioid effects is needed. Especially in combination with propofol it is used for target controlled infusion (TCI). The second part of the article shows the differences between groups of patients regarding the use of remifentanil.
September 2017: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://www.readbyqxmd.com/read/28883672/comparison-of-different-analgesic-techniques-for-pain-relief-during-extracorporeal-shock-wave-lithotripsy-a-double-blind-randomized-clinical-trial
#8
Afsaneh Fouladi, Aria Soleimani
BACKGROUND: Most patients experience some degree of pain during extracorporeal shock waves lithotripsy (ESWL). AIM: The aim of this study was to evaluate the effect of target-controlled infusion (TCI) of remifentanil or sufentanil and patient-controlled analgesia (PCA) with sufentanil or morphine for pain relief during ESWL. MATERIALS AND METHODS: In a double blind, randomized clinical trial, a total of 60 patients who were scheduled for elective ESWL, randomly assigned into four groups (A, B, C and D)...
June 2017: Acta Informatica Medica: AIM
https://www.readbyqxmd.com/read/28865915/anaesthetic-depth-control-using-closed-loop-anaesthesia-delivery-system-vs-target-controlled-infusion-in-patients-with-moderate-to-severe-left-ventricular-systolic-dysfunction
#9
V Mahajan, T Samra, G D Puri
OBJECTIVES: To compare the efficacy of anaesthetic depth control using Closed Loop Anaesthesia Delivery System (CLADS) and Target Controlled Infusion (TCI) in patients with moderate to severe left ventricular dysfunction (LVSD). DESIGN: Randomized control trial. PATIENTS: Forty ASA III/IV adult patients with moderate to severe LVSD scheduled for open heart surgery. INTERVENTIONS: Propofol was administered using CLADS or TCI for maintaining BIS of 50...
August 30, 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28865682/purification-of-trypanosoma-cruzi-metacyclic-trypomastigotes-by-ion-exchange-chromatography-in-sepharose-deae-a-novel-methodology-for-host-pathogen-interaction-studies
#10
Lissa Cruz-Saavedra, Marina Muñoz, Cielo León, Manuel Alfonso Patarroyo, Gabriela Arevalo, Paula Pavia, Gustavo Vallejo, Julio César Carranza, Juan David Ramírez
Metacyclic trypomastigotes are essential for the understanding of the biology of Trypanosoma cruzi, the agent of Chagas disease. However, obtaining these biological stages in axenic medium is difficult. Techniques based on charge and density of the parasite during different stages have been implemented, without showing a high efficiency in the purification of metacyclic trypomastigotes. So far, there is no protocol implemented where sepharose-DEAE is used as a resin. Therefore, herein we tested its ability to purify metacyclic trypomastigotes in Liver Infusion Triptose (LIT) medium cultures...
November 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/28859399/microvesicles-released-during-the-interaction-between-trypanosoma-cruzi-tci-and-tcii-strains-and-host-blood-cells-inhibit-complement-system-and-increase-the-infectivity-of-metacyclic-forms-of-host-cells-in-a-strain-independent-process
#11
M P Wyllie, M I Ramirez
Extracellular vesicles, whether microvesicles (MVs) or exosomes, shed by pathogens transfer virulence factors and biomolecules to host cells, thereby altering the host's susceptibility to infection. We have previously demonstrated that MV release is increased during the interaction between the infective forms of Trypanosoma cruzi and host cells. MVs confer parasite resistance to complement-mediated lysis and enhance parasite invasion. In this study, we show that differences exist in the levels of MVs released during the interaction between metacyclic trypomastigotes of different T...
September 29, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28859277/absolute-quantification-of-aggregatibacter-actinomycetemcomitans-in-patients-carrying-haplotypes-associated-with-susceptibility-to-chronic-periodontitis-multifaceted-evaluation-with-periodontitis-covariants
#12
Thamiris Cirelli, Livia S Finoti, Sâmia C T Corbi, Giovana Anovazzi, Rafael Nepomuceno, Silvana R P Orrico, Joni A Cirelli, Márcia P A Mayer, Raquel M Scarel-Caminaga
This study aimed to evaluate the association between haplotypes in the interleukin 8 (IL8) and IL4 genes previously associated to chronic periodontitis (CP) and the levels of Aggregatibacter actinomycetemcomitans (A.a.) in subgingival sites of patients with and without CP. Moreover, multifaceted evaluations were made to search associations among patients' genetic background with the A.a. levels and previous clinical/immunological/microbiological findings. Subgingival sites (n = 596) of 104 patients were divided into susceptible to CP by the IL8 haplotype ATC/TTC (IL8+); non-susceptible to CP by the IL8 AGT/TTC (IL8-); susceptible to CP by the IL4 TCI/CCI (IL4+); protection against CP by the IL4 TTD/CTI (IL4-)...
September 29, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28850375/new-evidence-for-a-pain-personality-a-critical-review-of-the-last-120-years-of-pain-and-personality
#13
REVIEW
Brooke Naylor, Simon Boag, Sylvia Maria Gustin
BACKGROUND: Personality traits may influence development and adjustment to ongoing pain. Over the past 120 years, there has been considerable research into the relationship between pain and personality. This paper presents new evidence for common personality traits found amongst chronic pain sufferers. In particular, it evaluates evidence for Cloninger's biopsychosocial model of personality in distinguishing typical personality features of chronic pain sufferers. It evaluates this evidence in the context of the past 120 years of research including psychodynamic formulations, MMPI studies, personality disorder investigations, and the influence of neuroticism on chronic pain...
July 28, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/28831256/comorbidity-of-schizophrenia-and-social-phobia-impact-on-quality-of-life-hope-and-personality-traits-a-cross-sectional-study
#14
Kristyna Vrbova, Jan Prasko, Marie Ociskova, Michaela Holubova
OBJECTIVE: The purpose of the study was to explore whether the comorbidity of social phobia affects symptoms severity, positive and negative symptoms, self-stigma, hope, and quality of life in patients with schizophrenia spectrum disorders. METHODS: This is a cross-sectional study in which all participants completed the Internalized Stigma of Mental Illness (ISMI) scale, Adult Dispositional Hope Scale (ADHS), Liebowitz Social Anxiety Scale (LSAS), Beck Anxiety Inventory (BAI), Beck Depression Inventory-II (BDI-II), Positive and Negative Syndrome Scale (PANSS), Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q), Temperament and Character Inventory - Revised (TCI-R), and the demographic questionnaire...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28800358/global-change-in-the-trophic-functioning-of-marine-food-webs
#15
Aurore Maureaud, Didier Gascuel, Mathieu Colléter, Maria L D Palomares, Hubert Du Pontavice, Daniel Pauly, William W L Cheung
The development of fisheries in the oceans, and other human drivers such as climate warming, have led to changes in species abundance, assemblages, trophic interactions, and ultimately in the functioning of marine food webs. Here, using a trophodynamic approach and global databases of catches and life history traits of marine species, we tested the hypothesis that anthropogenic ecological impacts may have led to changes in the global parameters defining the transfers of biomass within the food web. First, we developed two indicators to assess such changes: the Time Cumulated Indicator (TCI) measuring the residence time of biomass within the food web, and the Efficiency Cumulated Indicator (ECI) quantifying the fraction of secondary production reaching the top of the trophic chain...
2017: PloS One
https://www.readbyqxmd.com/read/28758184/motor-evoked-potentials-and-bis-guided-anaesthesia-in-image-guided-mini-invasive-neurosurgery-of-supratentorial-tumors-nearby-the-cortico-spinal-tract
#16
Roberto Cordella, Eleonora Orena, Francesco Acerbi, Elena Beretta, Dario Caldiroli, Francesco Dimeco, Carla Carozzi
AIM: to describe and evaluate the anaesthesiological regimen used in neurophysiologically monitored image-guided mini-invasive neurosurgery. MATERIAL AND METHODS: 24 patients underwent elective surgery under general anaesthesia that was administered through Target Controlled Infusion (TCI) for effect-site concentration (Ce) of Propofol and Remifentanil, targeting Bispectral Index (BIS) in the 40-60 intervals. Stimulating intensity of transcranial motor evoked potentials (tMEP), BIS index, Propofol and Remifentanil Ce were collected at MEPs threshold (T) definition (respectively BIS@T, CeProp@T and CeRemi@T)...
June 14, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/28746529/ultrasound-guided-intrapleural-positioning-of-pleural-catheters-influence-on-immediate-lung-expansion-and-pleurodesis-in-patients-with-recurrent-malignant-pleural-effusion
#17
Pedro Henrique Xavier Nabuco de Araujo, Ricardo Mingarini Terra, Thiago da Silva Santos, Rodrigo Caruso Chate, Antonio Fernando Lins de Paiva, Paulo Manuel Pêgo-Fernandes
Objective: To evaluate the role of intrapleural positioning of a pleural catheter in early lung expansion and pleurodesis success in patients with recurrent malignant pleural effusion (RMPE). Methods: This was a retrospective study nested into a larger prospective cohort study including patients with RMPE recruited from a tertiary university teaching hospital between June of 2009 and September of 2014. The patients underwent pleural catheter insertion followed by bedside pleurodesis...
May 2017: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/28743151/-remifentanil-up2date-part-1
#18
Stefan Bushuven, Sascha Kreuer, Peter Kranke
Remifentanil is a short-acting opioid of high analgetic potency and superior controllability. It is widely used in day-case surgery, procedural sedation, for reduction of recovery-times and obstetrics and whenever excellent controllability of opioid effects is needed. Especially in combination with Propofol it is used for target-controlled infusion (TCI). The first part of the article provides readers with information about historical aspects, pharmacological characteristics, effects and side effects of remifentanil...
July 2017: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://www.readbyqxmd.com/read/28717972/characteristics-of-patients-in-an-eating-disorder-sample-who-dropped-out-2-year-follow-up
#19
Andrés Gómez Del Barrio, María Yolanda Vellisca Gonzalez, Jana González Gómez, José Ignacio Latorre Marín, Laura Carral-Fernández, Santos Orejudo Hernandez, Inés Madrazo Río-Hortega, Laura Moreno Malfaz
OBJECTIVE: This manuscript explores the characteristics of individuals diagnosed with an eating disorder who dropped out of treatment, compared with those who completed it. METHOD: The participants were 196 patients diagnosed with eating disorders (according to DSM-IV-TR criteria) who consecutively began treatment for the first time in an eating disorders unit. They were assessed at baseline with a set of questionnaires evaluating eating habits, temperament, and general psychopathology...
July 17, 2017: Eating and Weight Disorders: EWD
https://www.readbyqxmd.com/read/28707524/applicability-of-cameriere-s-and-drusini-%C3%AF-s-age-estimation-methods-to-a-sample-of-turkish-adults
#20
Boyacioglu Dogru Hatice, Avcu Nihal, Akkaya Nursel, Yilanci Humeyra Ozge, Dincer Goksuluk
OBJECTIVES: The aim of this study was to investigate the applicability of Drusini's and Cameriere's methods to a sample of Turkish people. METHODS: Panoramic images of 200 individuals were allocated into two groups as study and test groups and examined by two observers. Tooth coronal indexes (TCI), which is the ratio between coronal pulp cavity height and crown height, were calculated in the mandibular first and second premolars and molars. Pulp/tooth area ratios (ARs) were calculated in the maxillary and mandibular canine teeth...
October 2017: Dento Maxillo Facial Radiology
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