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https://www.readbyqxmd.com/read/28549082/pharmacokinetics-and-pharmacodynamics-of-propofol-changes-in-patients-with-frontal-brain-tumours
#1
M M Sahinovic, D J Eleveld, T Miyabe-Nishiwaki, M M R F Struys, A R Absalom
Background: Models of propofol pharmacokinetics and pharmacodynamics developed in patients without brain pathology are widely used for target-controlled infusion (TCI) during brain tumour excision operations. The goal of this study was to determine if the presence of a frontal brain tumour influences propofol pharmacokinetics and pharmacodynamics and existing PK-PD model performance. Methods: Twenty patients with a frontal brain tumour and 20 control patients received a propofol infusion to achieve an induction-emergence-induction anaesthetic sequence...
May 26, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28548279/significant-decreases-in-blood-propofol-concentrations-during-adrenalectomy-for-phaeochromocytoma
#2
Tatsunori Watanabe, Haruhiko Hiraoka, Takuya Araki, Daisuke Nagano, Tohru Aomori, Tomonori Nakamura, Koujirou Yamamoto, Hiroshi Baba
AIM: The kinetics of propofol are influenced by cardiac output. The aim of this study was to examine changes in blood propofol concentrations during phaeochromocytoma surgery using target-controlled infusion (TCI) anaesthesia with propofol. METHODS: This is a prospective observational study. Ten patients with phaeochromocytoma who underwent unilateral adrenalectomy were included. Cardiac output was measured using an arterial pressure-based cardiac output analysis method...
May 26, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28541533/predictive-performance-of-the-modified-marsh-and-schnider-models-for-propofol-in-underweight-patients-undergoing-general-anaesthesia-using-target-controlled-infusion
#3
Y H Lee, G H Choi, K W Jung, B H Choi, J Y Bang, E K Lee, B M Choi, G J Noh
Background: : In our preliminary study, the modified Marsh (M-Marsh) model caused an inadvertent underdosing of propofol in underweight patients. However, the predictive performance of the M-Marsh and Schnider models incorporated in commercially available target-controlled infusion (TCI) pumps was not evaluated in underweight patients. Methods: : Thirty underweight patients undergoing elective surgery were randomly allocated to receive propofol via TCI using the M-Marsh or Schnider models...
May 24, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28538227/self-directedness-predicts-quality-of-life-in-individuals-with-psychotic-experiences-a-1-year-follow-up-study
#4
Letícia Oliveira Alminhana, Miguel Farias, Gordon Claridge, C Robert Cloninger, Alexander Moreira-Almeida
There is a high prevalence of psychotic-like experiences in nonclinical patient cohorts from Brazil. This study aimed to test whether personality dimensions, as well as schizotypy, are important predictors of quality of life (QoL) in individuals with psychotic experiences (PE). METHOD: 115 participants were recruited from Spiritist Centers in Brazil. At the 1-year follow up, 90 participants (78%) were reassessed. Instruments were the SCID-I (Structured Clinical Interview for DSM-IV), TCI-R 140 (Revised Temperament and Character Inventory), OLIFE-R (Oxford-Liverpool Inventory of Feelings and Experiences), and WHOQOL-BREF (World Health Organization QoL Instrument)...
May 25, 2017: Psychopathology
https://www.readbyqxmd.com/read/28528876/modeling-covalent-modifier-drugs
#5
REVIEW
Ernest Awoonor-Williams, Andrew G Walsh, Christopher N Rowley
In this review, we present a summary of how computer modeling has been used in the development of covalent modifier drugs. Covalent modifier drugs bind by forming a chemical bond with their target. This covalent binding can improve the selectivity of the drug for a target with complementary reactivity and result in increased binding affinities due to the strength of the covalent bond formed. In some cases, this results in irreversible inhibition of the target, but some targeted covalent inhibitor (TCI) drugs bind covalently but reversibly...
May 18, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28500623/simultaneous-inhibition-of-nmda-and-mglu1-5-receptors-by-levo-corydalmine-in-rat-spinal-cord-attenuates-bone-cancer-pain
#6
Wen-Ling Dai, Bing Yan, Nan Jiang, Juan-Juan Wu, Xiu-Feng Liu, Ji-Hua Liu, Bo-Yang Yu
Bone cancer pain is a challenge for its not completely clarified mechanism and broad clinical morbidity. Therefore, novel and more effective drugs are urgent needed for improvement of patients' quality of life. Glutamate receptors have been associated with the development of the central sensitization of chronic pain. Inhibition of N-methyl-D-aspartate (NMDA) and metabotropic glutamate (mGlu) receptors can effectively attenuate bone cancer pain respectively. Herein, our results indicated that levo-Corydalmine (l-CDL), a compound from Corydalis yanhusuo W...
May 13, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28499908/identification-of-novel-mammalian-hosts-and-brazilian-biome-geographic-distribution-of-trypanosoma-cruzi-tciii-and-tciv
#7
Juliana Helena S Barros, Samanta Cristina C Xavier, Daniele Bilac, Valdirene Santos Lima, Maria Augusta Dario, Ana Maria Jansen
Trypanosoma cruzi is a parasitic protozoan responsible for Chagas disease. Seven different Discrete Typing Units (DTUs) of T. cruzi are currently identified in nature: TcI-TcVI, and TcBat whose distribution patterns in nature, hosts/reservoirs and eco-epidemiological importance are still little known. Here, we present novel data on the geographic distribution and diversity of mammalian hosts and vectors of T. cruzi DTUs TcIII and TcIV. In this study, we analyzed 61 T. cruzi isolates obtained from 18 species of mammals (five orders) and two Hemiptera genera...
May 10, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28499837/information-processing-of-the-rorschach-s-traumatic-content-index-in-trauma-exposed-adults-an-event-related-potential-erp-study
#8
Gil Zukerman, Esther Ben- Itzchak, Leah Fostick, Rinat Armony-Sivan
PTSD elicits hypervigilance to trauma-related stimuli. Our novel research examined event-related potentials from Blood, Anatomy, and Morbid content derived from the Rorschach's traumatic content index (TCI). Participants included: 16 with PTSD, 24 trauma-exposed without PTSD (non-PTSD), and 16 non-traumatized Controls. P3 oddball paradigms were used with TCI-derived Distractors and neutral Targets/Standards. We predicted larger P3 amplitudes in the context of TCI-related Distractors among trauma-exposed participants...
May 10, 2017: Biological Psychology
https://www.readbyqxmd.com/read/28495405/trypanosoma-cruzi-i-towards-the-need-of-genetic-subdivision-part-ii
#9
REVIEW
Juan David Ramírez, Carolina Hernández
Chagas disease is a complex zoonosis caused by the kinetoplastid parasite Trypanosoma cruzi. This protozoan exhibits remarkable genetic diversity evinced in at least six Discrete Typing Units (DTUs) with the foreseen emergence of a genotype associated to bats (TcBat). T. cruzi I is the DTU with the broadest geographical distribution and associated to severe cardiomyopathies. In 2011, we published a review questioning the need for genetic subdivision within TcI. However, after six years of intensive research herein, we attempted to determine if TcI should be subdivided or not in the light of the current genetic, biological, clinical and ecological data...
May 8, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28489044/what-type-of-transitional-care-effectively-reduced-mortality-and-improved-adl-of-stroke-patients-a-meta-analysis
#10
Yuncui Wang, Fen Yang, Hao Shi, Chongming Yang, Hui Hu
Stroke is a major cause of disability and mortality worldwide; yet; prior to this study; there had been no sufficient evidence to support the effectiveness of various transitional care interventions (TCI) on the disability and mortality of stroke survivors. This meta-analysis aimed to assess the effectiveness of TCI in reducing mortality and improving the activities of daily life (ADL) of stroke patients. PubMed; Web of Science; OVID; EMBASE; CINAHL; and Sino-Med were searched for articles published before November 2016...
May 10, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28481169/a-comparison-of-antidepressants-with-without-naltrexone-on-sexual-side-effects
#11
M Thapa, I Petrakis, E Ralevski
OBJECTIVE: The aim of the study was to compare the rate of sexual side effects of a serotonin reuptake inhibitor (SSRI) paroxetine versus tricyclic (TCI) desipramine and to examine the effect of co-prescription of naltrexone on sexual side effects among participants in a randomized clinical trial. METHODS: This was a secondary analysis (N = 88) of veterans who participated in a 12 week trial. All veterans were randomized into one of four treatment groups: a) desipramine/naltrexone, b) desipramine/placebo, c) paroxetine/naltrexone and d) paroxetine/placebo...
May 8, 2017: Journal of Dual Diagnosis
https://www.readbyqxmd.com/read/28448425/vulnerability-to-psychopathology-and-dimensions-of-personality-in-patients-with-fibromyalgia
#12
Alba Garcia-Fontanals, Mariona Portell, Susanna García-Blanco, Violant Poca-Dias, Ferran García-Fructuoso, Marina López-Ruiz, Teresa Gutiérrez-Rosado, Montserrat Gomà-I-Freixanet, Joan Deus
OBJECTIVE: Fibromyalgia (FM) patients may present psychopathology and some characteristic personality traits that may affect their adaptation to the disease. This paper aims to study the relationship between personality dimensions according to the psychobiological model of Cloninger and the presence of psychopathology. METHOD: The study sample consisted of 42 patients with FM and 38 healthy controls. The assessment instruments administered were the Temperament and Character Inventory (TCI-R) and the Millon Clinical Multiaxial Inventory (MCMI-III)...
April 26, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28448245/temperament-character-profile-and-psychopathologies-in-patients-with-alopecia-areata
#13
Ali Talaei, Yalda Nahidi, Golsan Kardan, Lida Jarahi, Behzad Aminzadeh, Hasan Jahed Taherani, Mahsa Nahidi, Maliheh Ziaee
The aim of this study is to investigate psychopathologies and the temperament-character profile of Alopecia Areata patients and to compare them with healthy controls. Patients and controls who presented at a dermatology clinic were selected by convenience sampling to respond to Temperament and Character Inventory (TCI), SCL-90-R, and a checklist about the demographic data and their dermatologic and psychiatric history. Patients reported higher harm avoidance and reward dependence than controls (Cohen's d =...
April 27, 2017: Journal of General Psychology
https://www.readbyqxmd.com/read/28417467/retraction-statement-cxcl12-cxcr4-chemokine-signaling-in-spinal-glia-induces-pain-hypersensitivity-through-mapks-mediated-neuroinflammation-in-bone-cancer-rats
#14
(no author information available yet)
'CXCL12/CXCR4 chemokine signaling in spinal glia induces pain hypersensitivity through MAPKs-mediated neuroinflammation in bone cancer rats' by Hu X.-M., Liu Y.-N., Zhang H.-L., Cao S.-B., Zhang T., Chen L.-P. and Shen W. The above article from Journal of Neurochemistry, published online on 26 January 2015 and in volume 132, issue 4, pages 452-463 (available through www.onlinelibrary.wiley.com), and its subsequent Corrigendum, published online on 5 February 2015 and in volume 132, issue 4, p. 487, have been retracted by agreement between the Journal's Editor-in-Chief, Jörg Schulz, corresponding author Wen Shen on behalf of the authors, and John Wiley & Sons Ltd...
May 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28410884/the-effect-of-transcranial-direct-current-stimulation-on-motor-sequence-learning-and-upper-limb-function-after-stroke
#15
Melanie K Fleming, John C Rothwell, Laszlo Sztriha, James T Teo, Di J Newham
OBJECTIVE: To assess the impact of electrode arrangement on the efficacy of tDCS in stroke survivors and determine whether changes in transcallosal inhibition (TCI) underlie improvements. METHODS: 24 stroke survivors (3-124months post-stroke) with upper limb impairment participated. They received blinded tDCS during a motor sequence learning task, requiring the paretic arm to direct a cursor to illuminating targets on a monitor. Four tDCS conditions were studied (crossover); anodal to ipsilesional M1, cathodal to contralesional M1, bihemispheric, sham...
March 31, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28381402/transcutaneous-immunization-with-a-bandaid-prevents-experimental-otitis-media-in-a-polymicrobial-model
#16
Laura A Novotny, John D Clements, Steven D Goodman, Lauren O Bakaletz
Otitis media (OM) is a common pediatric disease and nontypeable Haemophilus influenzae (NTHI) is the predominant pathogen in chronic OM, recurrent OM and OM associated with treatment failure. OM is also a polymicrobial disease, wherein an upper respiratory tract viral infection predisposes to ascension of NTHI from the nasopharynx, the site of colonization, to the normally sterile middle ear, resulting in disease. Using a clinically relevant viral-bacterial co-infection model of NTHI-induced OM, we performed transcutaneous immunization (TCI) via a bandaid delivery system to administer each of three promising NTHI vaccine candidates derived from bacterial adhesive proteins and biofilm mediators: rsPilA, chimV4 and integration host factor...
April 5, 2017: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/28370664/an-acute-bout-of-exercise-modulates-both-intracortical-and-interhemispheric-excitability
#17
J L Neva, K E Brown, C S Mang, B A Francisco, L A Boyd
Primary motor cortex (M1) excitability is modulated following a single session of cycling exercise. Specifically, short-interval intracortical inhibition and intracortical facilitation are altered following a session of cycling, suggesting that exercise affects the excitability of varied cortical circuits. Yet we do not know whether a session of exercise also impacts the excitability of interhemispheric circuits between, and other intracortical circuits within, M1. Here we present two experiments designed to address this gap in knowledge...
March 30, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28364198/drug-induced-sleep-endoscopy-with-target-controlled-infusion-using-propofol-and-monitored-depth-of-sedation-to-determine-treatment-strategies-in-obstructive-sleep-apnea
#18
Clemens Heiser, Phillippe Fthenakis, Alexander Hapfelmeier, Sebastian Berger, Benedikt Hofauer, Winfried Hohenhorst, Eberhard F Kochs, Klaus J Wagner, Guenther M Edenharter
BACKGROUND: Drug-induced sleep endoscopy (DISE) has become an important diagnostic examination tool in the treatment decision process for surgical therapies in the treatment of obstructive sleep apnea (OSA). Currently, there is a variety of regimes for the performance of DISE, which renders comparison and assessment across results difficult. It remains unclear how the different regimes influence the findings of the examination and the resulting conclusions and treatment recommendations...
March 31, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28350449/long-chain-4-aminoquinolines-as-quorum-sensing-inhibitors-in-serratia-marcescens-and-pseudomonas-aeruginosa
#19
Ivana Aleksić, Sandra Šegan, Filip Andrić, Mario Zlatović, Ivana Moric, Dejan M Opsenica, Lidija Senerovic
Antibiotic resistance has become a serious global threat to public health; therefore, improved strategies and structurally novel antimicrobials are urgently needed to combat infectious diseases. Here we report a new type of highly potent 4-aminoquinoline derivatives as quorum sensing inhibitors in Serratia marcescens and Pseudomonas aeruginosa, exhibiting weak bactericidal activities (minimum inhibitory concentration (MIC) > 400 μM). Through detailed structure-activity study, we have identified 7-Cl and 7-CF3 substituted N-dodecylamino-4-aminoquinolines (5 and 10) as biofilm formation inhibitors with 50% biofilm inhibition at 69 μM and 63 μM in S...
April 10, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28336396/tumor-control-index-as-a-new-tool-to-assess-tumor-growth-in-experimental-animals
#20
William L Corwin, Hakimeh Ebrahimi-Nik, Stephanie M Floyd, Pouya Tavousi, Ion I Mandoiu, Pramod K Srivastava
Measurement of tumor diameters, tumor volumes, or area under the curve has been traditionally used to quantitate and compare tumor growth curves in immune competent as well as immune-compromised mice and rats. Here, using tumor growth data from a large number of mice challenged with live tumor cells, we describe the use of a new composite parameter, Tumor Control Index (TCI) as an alternative method to do the same. This index, comprised of three distinct values, the Tumor Inhibition Score, Tumor Rejection Score, and Tumor Stability Score, provides a complete picture of nearly every aspect of tumor growth in large numbers of animals, can be deduced automatically from tumor diameter or volume data, and can be used to compare several groups of animals in different experiments...
March 20, 2017: Journal of Immunological Methods
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