Maheen Z Abidi, Triin Umbleja, Edgar T Overton, Tricia Burdo, Jacqueline M Flynn, Michael T Lu, Jana Taron, Samuel R Schnittman, Kathleen V Fitch, Markella V Zanni, Carl J Fichtenbaum, Carlos Malvestutto, Judith A Aberg, Evelynne S Fulda, Allison Ross Eckard, Jennifer Manne-Goehler, Jessica J Tuan, Heather J Ribaudo, Pamela S Douglas, Steven K Grinspoon, Todd T Brown, Kristine M Erlandson
BACKGROUND: Cytomegalovirus (CMV) seropositivity is associated with poor outcomes, including physical function impairment, in people without HIV. We examined associations between CMV IgG titer and physical function in virologically suppressed people with HIV (PWH). METHODS: REPRIEVE is a double-blind randomized trial evaluating pitavastatin for primary prevention of atherosclerotic cardiovascular disease in PWH. This analysis focused on participants enrolled in a sub-study with additional biomarker testing, imaging [coronary CT angiography], and physical function measures at entry...
January 2, 2024: Journal of Acquired Immune Deficiency Syndromes: JAIDS