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HIV cognitive impairment

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https://www.readbyqxmd.com/read/29777462/a-composite-of-multisystem-injury-and-neurocognitive-impairment-in-hiv-infection-association-with-everyday-functioning
#1
María J Marquine, Ilse Flores, Rujvi Kamat, Neco Johnson, Anya Umlauf, Scott Letendre, Dilip Jeste, Igor Grant, David Moore, Robert K Heaton
The Veterans Aging Cohort Study (VACS) Index is a composite marker of multisystem injury among HIV-infected persons. We aimed to examine its cross-sectional association with functional outcomes, after considering neurocognitive impairment (NCI) and other well-established correlates of everyday functioning among HIV-infected persons. Participants included 670 HIV-infected adults (ages 18-76; 88% male; 63% non-Hispanic White; median current CD4 = 404 cells/mm3 ; 67% on antiretroviral therapy; AIDS = 63%) enrolled in observational studies at the University of California San Diego HIV Neurobehavioral Research Program...
May 17, 2018: Journal of Neurovirology
https://www.readbyqxmd.com/read/29771285/increased-dolutegravir-peak-concentrations-in-people-living-with-hiv-aged-60-and-over-and-analysis-of-sleep-quality-and-cognition
#2
Emilie R Elliot, Xinzhu Wang, Suveer Singh, Bryony Simmons, Jaime H Vera, Robert F Miller, Colin Fitzpatrick, Graeme Moyle, Myra McClure, Marta Boffito
Background: Demographic data show an increasingly aging HIV population worldwide. Recent concerns over dolutegravir-related neuropsychiatric toxicity have emerged, particularly amongst older HIV patients. We describe the pharmacokinetics (PK) of dolutegravir (DTG) 50mg once daily in people living with HIV (PLWH) aged 60 and older. Additionally, to address the call for prospective neuropsychiatric toxicodynamic data, we evaluate changes in sleep quality and cognitive function after switching to abacavir (ABC)/lamivudine (3TC)/DTG, over 6 months in this population...
May 16, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29747571/axonal-chronic-injury-in-treatment-na%C3%A3-ve-hiv-adults-with-asymptomatic-neurocognitive-impairment-and-its-relationship-with-clinical-variables-and-cognitive-status
#3
Rui-Li Li, Jun Sun, Zhen-Chao Tang, Jing-Ji Zhang, Hong-Jun Li
BACKGROUND: HIV is a neurotropic virus, and it can bring about neurodegeneration and may even result in cognitive impairments. The precise mechanism of HIV-associated white matter (WM) injury is unknown. The effects of multiple clinical contributors on WM impairments and the relationship between the WM alterations and cognitive performance merit further investigation. METHODS: Diffusion tensor imaging (DTI) was performed in 20 antiretroviral-naïve HIV-positive asymptomatic neurocognitive impairment (ANI) adults and 20 healthy volunteers...
May 10, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29746300/impact-of-glycemic-status-on-longitudinal-cognitive-performance-in-men-with-and-without-hiv-infection
#4
Jingyan Yang, Lisa P Jacobson, James T Becker, Andrew Levine, Eileen M Martin, Cynthia A Munro, Frank J Palella, Jordan E Lake, Ned C Sacktor, Todd T Brown
OBJECTIVES: To determine the relationship between glycemic status and cognitive performance in men living with (MLWH) and without HIV infection. DESIGN: A prospective HIV/AIDS cohort study in four U.S. cities between 1999 and 2016. METHODS: Glycemic status was categorized as normal glucose (NG), impaired fasting glucose (IFG), controlled diabetes mellitus (DM) and uncontrolled DM at each semi-annual visit. Cognitive performance was evaluated using nine neuropsychological tests which measure attention, constructional ability, verbal learning, executive functioning, memory, and psychomotor speed...
May 8, 2018: AIDS
https://www.readbyqxmd.com/read/29746297/microglial-activation-is-inversely-associated-with-cognition-in-individuals-living-with-hiv-on-effective-antiretroviral-therapy
#5
Leah H Rubin, Ned Sacktor, Jason Creighton, Yong Du, Christopher J Endres, Martin G Pomper, Jennifer M Coughlin
OBJECTIVE: Despite viral suppression, HIV-associated cognitive impairment persists and may be partially due to persistent immune signaling by cells of the myeloid-lineage. Here we aimed to understand the contribution of activated microglia located in vulnerable brain regions (e.g., frontal, subcortical) of HIV-infected, virally suppressed (HIV+VS) individuals in relation to cognitive and motor function. DESIGN: 21 HIV+VS individuals underwent positron emission tomography (PET) with [C]DPA-713 to image the translocator protein 18 KDa (TSPO), a marker of microglial activation, and completed a comprehensive neuropsychological test battery...
May 9, 2018: AIDS
https://www.readbyqxmd.com/read/29741401/comparison-of-%C3%AE-2-microglobulin-serum-level-between-alzheimer-s-patients-cognitive-healthy-and-mild-cognitive-impaired-individuals
#6
Roberto Dominici, Dario Finazzi, Letizia Polito, Emanuela Oldoni, Giovanna Bugari, Alessandro Montanelli, Elio Scarpini, Daniela Galimberti, Antonio Guaita
BACKGROUND: Several studies performed in the last years on the brain, showed that beta2-microglobulin (β2m) and MHC can act independently of their canonical immune function to regulate normal brain development, synaptic plasticity and behaviour. Increased systemic levels of soluble β2m have been implicated in cognitive impairments like that associated with chronic hemodialysis, or aortic valve replacement. Increased soluble β2m has also been detected in the cerebral spinal fluid (CSF) of patients with HIV-associated dementia and Alzheimer's disease...
May 9, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29737506/hiv-1-protein-tat-1-72-impairs-neuronal-dendrites-via-activation-of-pp1-and-regulation-of-the-creb-bdnf-pathway
#7
Yu Liu, Deyu Zhou, Jiabin Feng, Zhou Liu, Yue Hu, Chang Liu, Xiaohong Kong
Despite the success of combined antiretroviral therapy in recent years, the prevalence of human immunodeficiency virus (HIV)-associated neurocognitive disorders in people living with HIV-1 is increasing, significantly reducing the health-related quality of their lives. Although neurons cannot be infected by HIV-1, shed viral proteins such as transactivator of transcription (Tat) can cause dendritic damage. However, the detailed molecular mechanism of Tat-induced neuronal impairment remains unknown. In this study, we first showed that recombinant Tat (1-72 aa) induced neurotoxicity in primary cultured mouse neurons...
May 8, 2018: Virologica Sinica
https://www.readbyqxmd.com/read/29736073/a-study-of-neuropsychological-profile-of-human-immunodeficiency-virus-positive-children-and-adolescents-on-antiretroviral-therapy
#8
Vasantmeghna S Murthy, Ajita S Nayak, Minal K Joshi, Kaneenica Ninawe
Aims: The aim is to study the neuropsychological and functional profile of children and adolescents with human immunodeficiency virus (HIV) infection on antiretroviral therapy (ART) and the association between the neuropsychological status and medical illness variables, treatment variables, and functional status in the cases of the sample and compare with normal controls. Materials and Methods: Forty-two HIV-positive children and adolescents on ART were evaluated and compared with 40 matched controls not known to be HIV-positive...
January 2018: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/29734219/correlation-between-inner-retinal-layer-thickness-and-cognitive-function-in-hiv-new-insights-from-an-exploratory-study
#9
Alessandro Invernizzi, Alessandra Acquistapace, Sara Bochicchio, Chiara Resnati, Stefano Rusconi, Marta Ferrari, Valentina Leta, Simone Pomati, Alexander Klistorner, Peter Mccluskey, Giovanni Staurenghi, Agostino Riva
OBJECTIVE: to compare retinal layer thickness in human immunodeficiency virus (HIV) infected subjects with (CI-HIV) and without (NCI-HIV) cognitive impairment, with a control population and to correlate it with the cognitive status of the patient and other clinical parameters. DESIGN: single center cross-sectional study METHODS:: Subjects with controlled HIV infection aged between 40 and 70 years and sex and age matched controls were enrolled. Retinal nerve fiber layer (RNFL), ganglion cell layer (GCL) and inner plexiform layer (IPL) thickness were assessed using optical coherence tomography...
May 3, 2018: AIDS
https://www.readbyqxmd.com/read/29732416/associations-of-mood-on-objective-and-subjective-cognitive-complaints-in-persons-living-with-hiv-aids
#10
Moka Yoo-Jeong, Ashley Anderson, Akm Fazlur Rahman, Maya Baumann, Jade McBroom, Drenna Waldrop-Valverde
Healthcare workers commonly rely on patient self-report to identify problems with cognitive functioning among Persons Living with HIV (PLWH). Self-reported cognitive complaints may not accurately reflect objective cognitive performance and may be obscured by co-occurring depression. The purpose of the current study was to examine the relationships among depression, subjective cognitive complaints, and objective cognitive performance in PLWH using measures easily administered by healthcare workers. Particularly, this study assessed the association between subjective cognitive complaints (MOS-HIV) and objective cognitive performance (mHDS) using a simple screening tool, as well as whether depressive symptoms (CES-D 10) moderated this relationship...
2018: Journal of HIV and AIDS
https://www.readbyqxmd.com/read/29729322/methamphetamine-augment-hiv-1-tat-mediated-memory-deficits-by-altering-the-expression-of-synaptic-proteins-and-neurotrophic-factors
#11
Anantha Ram Nookala, Daniel C Schwartz, Nitish S Chaudhari, Alexy Glazyrin, Edward B Stephens, Nancy E J Berman, Anil Kumar
Methamphetamine (METH) abuse is common among individuals infected with HIV-1 and has been shown to affect HIV replication and pathogenesis. These HIV-1 infected individuals also exhibit greater neuronal injury and higher cognitive decline. HIV-1 proteins, specifically gp120 and HIV-1 Tat, have been earlier shown to affect neurocognition. HIV-1 Tat, a viral protein released early during HIV-1 replication, contributes to HIV-associated neurotoxicity through various mechanisms including production of pro-inflammatory cytokines, reactive oxygen species and dysregulation of neuroplasticity...
May 2, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29718082/integration-of-neuropsychological-services-in-a-va-hiv-primary-care-clinic
#12
Moira C Dux, Terry Lee-Wilk
The Department of Veteran Affairs (VA) is the largest health care provider for individuals with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS), with >28,000 Veterans with HIV/AIDS enrolled in care. Advances in medical treatment have improved the life-limiting effects of the disease, though many chronic symptoms persist. Comprehensive care is critical to manage the diverse constellation of symptoms. However, many patients face challenges to receiving optimal care due to limited resources, mistrust of health care providers, and/or co-occurring medical, psychiatric, and substance use disorders...
May 1, 2018: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29709610/effects-of-hiv-1-tat-protein-and-methamphetamine-exposure-on-visual-discrimination-and-executive-function-in-mice
#13
James P Kesby, Jerel A Fields, Ariel Chang, Hamza Coban, Cristian L Achim, Svetlana Semenova
Mild neurocognitive impairments are common in people with human immunodeficiency virus (HIV) infection. HIV-encoded proteins, such as trans-activator of transcription (TAT), contribute to neuropathology and cognitive function in medicated subjects. The combination of TAT and comorbid methamphetamine use may further impair neurocognitive function in HIV-positive individuals by affecting dopaminergic systems in the brain. The current study examined the effects of TAT protein expression and methamphetamine exposure on cognitive function and dopamine systems in mice...
April 27, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29707383/the-association-between-asymptomatic-and-mild-neurocognitive-impairment-and-adherence-to-antiretroviral-therapy-among-people-living-with-human-immunodeficiency-virus
#14
Violet Awori, Peter Mativo, Gerald Yonga, Reena Shah
Background: Asymptomatic cognitive impairment in human immunodeficiency virus (HIV)-infected patients has recently been recognised as part of HIV-associated neurocognitive disorders. This has been implicated as one of the causes of poor adherence to antiretroviral therapy (ART). Objective: To assess the association between neurocognitive impairment (asymptomatic and mild forms) and adherence to ART. Methods: This was a cross-sectional survey involving 218 participants consecutively sampled from those attending the HIV treatment clinic at Aga Khan University Hospital in Nairobi...
2018: Southern African Journal of HIV Medicine
https://www.readbyqxmd.com/read/29705930/united-states-national-trends-in-mortality-length-of-stay-los-and-associated-costs-of-cognitive-impairment-in-hiv-population-from-2005-to-2014
#15
Smit Patel, Neil U Parikh, Ravikumar Aalinkeel, Jessica L Reynolds, Rashmi Dmello, Stanley A Schwartz, Supriya D Mahajan
We evaluated national trends of in-hospital discharge rates, mortality outcomes, health care costs, length of stay in HIV patients with cognitive disorders. Neurological involvement in HIV is commonly associated with cognitive impairment termed as HIV-associated neurocognitive disorder (HAND) which includes a spectrum of neurocognitive dysfunction associated with HIV infection. Although severe and progressive neurocognitive impairment has become rare in HIV patients in the era of potent antiretroviral therapy, a majority of HIV patients have mild to moderate degree of neurocognitive impairment...
April 28, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29698322/lentiviral-infection-of-proliferating-brain-macrophages-in-hiv-and-simian-immunodeficiency-virus-encephalitis-despite-sterile-alpha-motif-and-histidine-aspartate-domain-containing-protein-1-expression
#16
Allison A Lindgren, Adam R Filipowicz, Julian B Hattler, Soon Ok Kim, Hye Kyung Chung, Marcelo J Kuroda, Edward M Johnson, Woong-Ki Kim
OBJECTIVE: HIV-1 infection of the brain and related cognitive impairment remain prevalent in HIV-1-infected individuals despite combination antiretroviral therapy. Sterile alpha motif and histidine-aspartate domain-containing protein 1 (SAMHD1) is a newly identified host restriction factor that blocks the replication of HIV-1 and other retroviruses in myeloid cells. Cell cycle-regulated phosphorylation at residue Thr592 and viral protein X (Vpx)-mediated degradation of SAMHD1 have been shown to bypass SAMHD1 restriction in vitro...
May 15, 2018: AIDS
https://www.readbyqxmd.com/read/29696578/motor-function-declines-over-time-in-human-immunodeficiency-virus-and-is-associated-with-cerebrovascular-disease-while-hiv-associated-neurocognitive-disorder-remains-stable
#17
Isabel M Elicer, Desiree Byrd, Uraina S Clark, Susan Morgello, Jessica Robinson-Papp
HIV-associated neurocognitive disorders (HAND) remain prevalent in the combined antiretroviral therapy (CART) era, especially the milder forms. Despite these milder phenotypes, we have shown that motor abnormalities persist and have quantified them with the HIV Dementia Motor Scale (HDMS). Our objectives were to replicate, in an independent sample, our prior findings that the HDMS is associated with cognitive impairment in HIV, while adding consideration of age-associated comorbidities such as cerebrovascular disease, and to examine the longitudinal trajectories of cognitive and motor dysfunction...
April 25, 2018: Journal of Neurovirology
https://www.readbyqxmd.com/read/29696153/intervention-mapping-to-develop-a-social-cognitive-theory-based-intervention-for-chronic-pain-tailored-to-individuals-with-hiv
#18
Jessica S Merlin, Sarah R Young, Mallory O Johnson, Michael Saag, William Demonte, Robert Kerns, Matthew J Bair, Stefan Kertesz, Janet M Turan, Meredith Kilgore, Olivio J Clay, Dorothy Pekmezi, Susan Davies
Chronic pain is an important comorbidity among individuals with HIV. Behavioral interventions are widely regarded as evidence-based, efficacious non-pharmacologic interventions for chronic pain in the general population. An accepted principle in behavioral science is that theory-based, systematically-developed behavioral interventions tailored to the unique needs of a target population are most likely to be efficacious. Our aim was to use Intervention Mapping to systematically develop a Social Cognitive Theory (SCT)-based intervention for chronic pain tailored to individuals with HIV that will improve pain intensity and pain-related functional impairment...
June 2018: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/29687402/verbal-and-spatial-working-memory-among-drug-using-hiv-infected-men-and-women
#19
Eileen Martin, M K Keutmann, J S Fogel, P M Maki, R Gonzalez, J Vassileva, L H Rubin, D Hardy
Working memory (WM) is a critical component of many neurocognitive functions. The literature has demonstrated consistently that WM impairment is more frequent and severe among substance-dependent individuals (SDIs) infected with HIV compared with uninfected SDIs; however, the SDIs who participated in these previous studies were primarily male. There are few published data on WM performance among HIV+ women with or without substance use disorders, and essentially no direct comparisons of WM performance between HIV+ men and women, regardless of substance use...
April 23, 2018: Journal of Neurovirology
https://www.readbyqxmd.com/read/29685540/resting-state-functional-connectivity-mri-analysis-in-human-immunodeficiency-virus-and-hepatitis-c-virus-co-infected-subjects-a-pilot-study
#20
Simone Corgiolu, Luigi Barberini, Jasjit S Suri, Antonella Mandas, Diego Costaggiu, Paola Piano, Fulvio Zaccagna, Pierleone Lucatelli, Antonella Balestrieri, Luca Saba
BACKGROUND AND PURPOSE: Hepatitis C virus (HCV) co-infection's role on cognitive impairment of human immunodeficiency virus (HIV) positive patients is still debated and functional neuroimaging evaluation on this matter is lacking. To provide further insight about HCV's neuro-effects on HIV associated neurocognitive disorder (HAND), we performed a pilot resting state (RS) functional connectivity magnetic resonance imaging (fcMRI) study to find eventual functional connectivity alteration that could reflect HCV related cognitive performance degradation...
May 2018: European Journal of Radiology
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