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https://www.readbyqxmd.com/read/28549526/mobile-phone-ecological-momentary-assessment-of-daily-stressors-among-people-living-with-hiv-elucidating-factors-underlying-health-related-challenges-in-daily-routines
#1
Shu Farmer, Deborah Mindry, W Scott Comulada, Dallas Swendeman
Stressful life events and daily hassles affect people living with HIV (PLWH). However, capturing stress-related events and cognitive impairment is often plagued with recall biases. Incorporating reliable information technology, such as mobile phones, can be a resourceful method for measuring health behaviors (MHB). We report findings from an MHB pilot study with 32 African American, Latino/Hispanic, and White PLWH from Los Angeles. Participants reported perceived stressors in their daily routines using a smartphone Ecological Momentary Assessment (EMA) application...
April 12, 2017: Journal of the Association of Nurses in AIDS Care: JANAC
https://www.readbyqxmd.com/read/28541084/the-feasibility-of-automated-eye-tracking-with-the-early-childhood-vigilance-test-of-attention-in-younger-hiv-exposed-ugandan-children
#2
Michael J Boivin, Jonathan Weiss, Ronak Chhaya, Victoria Seffren, Jorem Awadu, Alla Sikorskii, Bruno Giordani
OBJECTIVE: Tobii eye tracking was compared with webcam-based observer scoring on an animation viewing measure of attention (Early Childhood Vigilance Test; ECVT) to evaluate the feasibility of automating measurement and scoring. Outcomes from both scoring approaches were compared with the Mullen Scales of Early Learning (MSEL), Color-Object Association Test (COAT), and Behavior Rating Inventory of Executive Function for preschool children (BRIEF-P). METHOD: A total of 44 children 44 to 65 months of age were evaluated with the ECVT, COAT, MSEL, and BRIEF-P...
May 25, 2017: Neuropsychology
https://www.readbyqxmd.com/read/28541068/cognitive-behavioral-therapy-for-body-image-and-self-care-cbt-bisc-in-sexual-minority-men-living-with-hiv-a-randomized-controlled-trial
#3
Aaron J Blashill, Steven A Safren, Sabine Wilhelm, Jonathan Jampel, S Wade Taylor, Conall O'Cleirigh, Kenneth H Mayer
OBJECTIVE: Body image disturbance is a distressing and interfering problem among many sexual minority men living with HIV, and is associated with elevated depressive symptoms and poor HIV self-care (e.g., antiretroviral therapy [ART] nonadherence). The current study tested the preliminary efficacy of a newly created intervention: cognitive-behavioral therapy for body image and self-care (CBT-BISC) for this population. METHOD: The current study entailed a 2-arm randomized controlled trial (N = 44) comparing CBT-BISC to an enhanced treatment as usual (ETAU) condition...
May 25, 2017: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/28536861/heterogeneity-of-neuropsychological-impairment-in-hiv-infection-contributions-from-mild-cognitive-impairment
#4
REVIEW
Kathryn N Devlin, Tania Giovannetti
Despite longstanding acknowledgement of the heterogeneity of HIV-associated neurocognitive disorders (HAND), existing HAND diagnostic methods classify according to the degree of impairment, without regard to the pattern of neuropsychological strengths and weaknesses. Research in mild cognitive impairment (MCI) has demonstrated that classifying individuals into subtypes by both their level and pattern of impairment, using either conventional or statistical methods, has etiologic and prognostic utility. Methods for characterizing the heterogeneity of MCI provide a framework that can be applied to other disorders and may be useful in clarifying some of the current challenges in the study of HAND...
May 24, 2017: Neuropsychology Review
https://www.readbyqxmd.com/read/28534093/quality-of-life-among-perinatally-hiv-affected-and-hiv-unaffected-school-aged-and-adolescent-ugandan-children-a-multi-dimensional-assessment-of-wellbeing-in-the-post-haart-era
#5
A K Nkwata, S K Zalwango, F N Kizza, J N Sekandi, J Mutanga, M Zhang, P M Musoke, A E Ezeamama
OBJECTIVE: To examine quality of life (QOL) in perinatally HIV-infected (PHIV) or HIV-exposed uninfected (PHEU) vs. healthy HIV-unexposed uninfected (HUU) children during school-age/adolescence. METHODS: PHIV infection was diagnosed via DNA PCR. Current HIV status was confirmed by HIV rapid diagnostic test. Three HIV groups were defined: PHIV, PHEU, and HUU. QOL was assessed with proxy and self-report versions of the PedsQL™ 4.0 instrument at 6-18 years of age...
May 22, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28533442/the-role-of-shed-prp-c-in-the-neuropathogenesis-of-hiv-infection
#6
Bezawit W Megra, Eliseo A Eugenin, Joan W Berman
HIV-1 enters the CNS soon after peripheral infection and causes chronic neuroinflammation and neuronal damage that leads to cognitive impairment in 40-70% of HIV-infected people. The nonpathogenic cellular isoform of the human prion protein (PrP(c)) is an adhesion molecule constitutively expressed in the CNS. Previously, our laboratory showed that shed PrP(c) (sPrP(c)) is increased in the cerebrospinal fluid of HIV-infected people with cognitive deficits as compared with infected people with no impairment. In this article, we demonstrate that CCL2 and TNF-α, inflammatory mediators that are elevated in the CNS of HIV-infected people, increase shedding of PrP(c) from human astrocytes by increasing the active form of the metalloprotease ADAM10...
May 22, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28532283/the-feasibility-of-an-automated-eye-tracking-modified-fagan-test-of-memory-for-human-faces-in-younger-ugandan-hiv-exposed-children
#7
Ronak Chhaya, Jonathan Weiss, Victoria Seffren, Alla Sikorskii, Paula M Winke, Julius C Ojuka, Michael J Boivin
OBJECTIVE: The Fagan Test of Infant Intelligence (FTII) uses longer gaze length for unfamiliar versus familiar human faces to gauge visual-spatial encoding, attention, and working memory in infants. Our objective was to establish the feasibility of automated eye tracking with the FTII in HIV-exposed Ugandan infants. METHOD: The FTII was administered to 31 perinatally HIV-exposed noninfected (HEU) Ugandan children 6-12 months of age (11 boys; M = 0.69 years, SD = 0...
May 22, 2017: Child Neuropsychology: a Journal on Normal and Abnormal Development in Childhood and Adolescence
https://www.readbyqxmd.com/read/28527854/barriers-to-initiation-of-extended-release-naltrexone-among-hiv-infected-adults-with-alcohol-use-disorders
#8
Hélène Chokron Garneau, Alexandra Venegas, Richard Rawson, Lara A Ray, Suzette Glasner
Alcohol consumption is a major risk factor for the acquisition of HIV/AIDS and is associated with greater disease burden and mortality among those who become HIV-infected. Of the extant pharmacological treatments for alcohol use disorders, naltrexone is recognized as one of the most efficacious, producing robust reductions in alcohol craving and use. Given that treatment with oral naltrexone has been limited by problems with adherence, which are particularly prevalent among individuals with multiple chronic, co-occurring conditions, long-acting formulations may be a promising approach for HIV-infected substance users...
May 11, 2017: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/28525592/neurosyphilis-increases-hiv-associated-central-nervous-system-inflammation-but-does-not-explain-cognitive-impairment-in-hiv-infected-individuals-with-syphilis
#9
Emily L Ho, Clare L Maxwell, Shelia B Dunaway, Sharon K Sahi, Lauren C Tantalo, Sheila A Lukehart, Christina M Marra
Background: HIV-infected individuals with previous syphilis have cognitive impairment. We tested the hypothesis that neurosyphilis causes cognitive impairment in HIV by amplifying HIV-related CNS inflammation. Methods: 132 HIV-infected participants enrolled in a study of CSF abnormalities in syphilis underwent the mental alternation test (MAT), venipuncture and lumbar puncture. CSF concentrations of chemokine (C-X-C motif) ligand 10 (CXCL10), chemokine (C-C motif) ligand 2 (CCL2) and neurofilament light (NFL) were determined by commercial assays...
May 19, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28524758/seeking-safety-group-therapy-for-co-occurring-substance-use-disorder-and-ptsd-among-transgender-women-living-with-hiv-a-pilot-study
#10
Susannah Empson, Yvette P Cuca, Jennifer Cocohoba, Carol Dawson-Rose, Katy Davis, Edward L Machtinger
Transgender women living with HIV experience high rates of substance use, violence, and post-traumatic stress disorder (PTSD). Seeking Safety is a manualized, present-focused, cognitive-behavioral therapy program designed to address co-occurring substance use and PTSD. Seeking Safety has evidence of efficacy in a variety of populations but had not been evaluated specifically with people living with HIV or transgender women. We pilot-tested a 12-session Seeking Safety program with a group of transgender women living with HIV who reported substance use and a history of violence...
May 19, 2017: Journal of Psychoactive Drugs
https://www.readbyqxmd.com/read/28520614/incidence-of-neurological-disorders-among-hiv-infected-individuals-with-universal-health-care-in-taiwan-2000-through-2010
#11
Yi-Tseng Tsai, Yen-Chin Chen, Chen-Yang Hsieh, Wen-Chien Ko, Nai-Ying Ko
OBJECTIVE: To determine the incidence of and factors associated with neurological disorders in a large Taiwanese cohort of HIV-infected persons with free access to highly active antiretroviral therapy (HAART). DESIGN: A retrospective population-based cohort study was conducted using the National Health Insurance Research Database for the years 2000-2010. METHODS: We identified 13,316 HIV-positive persons from 2000 through 2010. We used direct standardization to calculate age- and sex-adjusted incidence rates based on the 2000 World Health Organization world standard population...
May 17, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28503143/impairments-of-motor-function-while-multitasking-in-hiv
#12
Sharif I Kronemer, Jordan A Mandel, Ned C Sacktor, Cherie L Marvel
Human immunodeficiency virus (HIV) became a treatable illness with the introduction of combination antiretroviral therapy (CART). As a result, patients with regular access to CART are expected to live decades with HIV. Long-term HIV infection presents unique challenges, including neurocognitive impairments defined by three major stages of HIV-associated neurocognitive disorders (HAND). The current investigation aimed to study cognitive and motor impairments in HIV using a novel multitasking paradigm. Unlike current standard measures of cognitive and motor performance in HIV, multitasking increases real-world validity by mimicking the dual motor and cognitive demands that are part of daily professional and personal settings (e...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28499423/could-cash-and-good-parenting-affect-child-cognitive-development-a-cross-sectional-study-in-south-africa-and-malawi
#13
Lorraine Sherr, Ana Macedo, Mark Tomlinson, Sarah Skeen, Lucie Dale Cluver
BACKGROUND: Social protection interventions, including cash grants and care provision have been shown to effectively reduce some negative impacts of the HIV epidemic on adolescents and families. Less is known about the role of social protection on younger HIV affected populations. This study explored the impact of cash grants on children's cognitive development. Additionally, we examined whether combined cash and care (operationalised as good parenting) was associated with improved cognitive outcomes...
May 12, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28492085/self-managing-hiv-aids-cultural-competence-and-health-among-women-in-nairobi-kenya
#14
Toni Copeland
Despite recent efforts to supply antiretroviral therapy, many in Africa are not receiving medication, instead relying on self-management in their attempts to remain healthy. In Kenya, the majority of those infected are women who are below the extreme poverty level. Building on research demonstrating a link between knowledge of HIV/AIDS management and the length of time HIV-positive women have lived in Nairobi, this article uses a cognitive anthropological approach that conceives of culture as shared models and explores the relationship between how well women know a cultural model of self-managing HIV/AIDS and health among women who are not receiving biomedical treatment...
May 11, 2017: Anthropology & Medicine
https://www.readbyqxmd.com/read/28486816/attitudes-towards-exercise-among-substance-using-older-adults-living-with-hiv-and-chronic-pain
#15
Annie L Nguyen, Jordan E Lake, M Carrington Reid, Suzette Glasner, Jessica Jenkins, Jury Candelario, Sarah Soliman, Homero E Del Pino, Alison A Moore
Chronic pain and substance use disorders occur commonly among HIV-infected persons. Recent CDC guidelines recommend non-pharmacologic approaches over opioid medications for the management of chronic pain. This is particularly relevant for persons with substance use disorders. Structured physical activity may be an effective strategy for pain reduction. We developed a combined cognitive-behavioral therapy (CBT) + exercise intervention to reduce pain, pain-related disability and substance use and improve physical function in older HIV-infected adults with chronic pain and substance use...
May 9, 2017: AIDS Care
https://www.readbyqxmd.com/read/28482682/longitudinal-development-of-cognitive-visuomotor-and-adaptive-behavior-skills-in-hiv-uninfected-children-aged-3-5-years-of-age-exposed-pre-and-perinatally-to-anti-retroviral-medications
#16
Mary Lou Smith, Klajdi Puka, Ramandeep Sehra, Stanley E Read, Ari Bitnun
Little is known about the neurodevelopmental outcomes of children older than 3 years of age born to HIV infected mother but who are HIV-uninfected (HEU), and who have been exposed in utero and early in life to HIV and to antiretroviral medications (ARVs). We conducted a longitudinal study of cognitive, visuomotor and adaptive function of HEU children, who were assessed at two ages, 3.5 and 5.5 years. Sixty-four children (33 female) were assessed. In comparison with population norms for their age, at 3.5 years of age they had scores significantly below age expectations on aspects of adaptive behavior, but at age 5...
May 8, 2017: AIDS Care
https://www.readbyqxmd.com/read/28481783/impact-of-perinatally-acquired-hiv-disease-upon-longitudinal-changes-in-memory-and-executive-functioning
#17
Kathleen M Malee, Miriam C Chernoff, Patricia A Sirois, Paige L Williams, Patricia A Garvie, Betsy L Kammerer, Lynnette L Harris, Molly L Nozyce, Cenk Yildirim, Sharon L Nichols
BACKGROUND: Little is known regarding effects of perinatally-acquired HIV infection (PHIV) on longitudinal change in memory and executive functioning (EF) during adolescence, despite the importance of these skills for independence in adulthood. METHODS: PHIV (n=144) and perinatally HIV-exposed uninfected youth (PHEU, n=79), ages 12-17, completed standardized tests of memory and EF at baseline and two years later. Changes from baseline for each memory and EF outcome were compared between PHEU and PHIV youth with (PHIV/C, n=39) and without (PHIV/non-C, n=105) history of CDC Class C (AIDS-defining) diagnoses...
May 5, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28480240/a-high-prevalence-rate-of-a-positive-screen-for-cognitive-impairment-in-patients-with-human-immunodeficiency-virus-attending-an-irish-clinic
#18
Patricia H McNamara, Robert Coen, Janice Redmond, Colin P Doherty, Colm Bergin
BACKGROUND: Human immunodeficiency virus (HIV)-associated neurocognitive disorders occurs in 20%-50% of HIV-positive patients. We undertook this study to assess the prevalence of a positive screen for cognitive impairment in the clinic population at our institution and to demonstrate the feasibility of implementing a screening program in routine clinical encounters. METHODS: This was a cross-sectional study, and patients were recruited prospectively between December 2010 and February 2013...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28472938/exploring-generative-mechanisms-of-the-antiretroviral-adherence-club-intervention-using-the-realist-approach-a-scoping-review-of-research-based-antiretroviral-treatment-adherence-theories
#19
Ferdinand C Mukumbang, Sara Van Belle, Bruno Marchal, Brian van Wyk
BACKGROUND: Poor retention in care and non-adherence to antiretroviral therapy (ART) continue to undermine the success of HIV treatment and care programmes across the world. There is a growing recognition that multifaceted interventions - application of two or more adherence-enhancing strategies - may be useful to improve ART adherence and retention in care among people living with HIV/AIDS. Empirical evidence shows that multifaceted interventions produce better results than interventions based on a singular perspective...
May 4, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28472928/using-the-multiphase-optimization-strategy-most-to-optimize-an-hiv-care-continuum-intervention-for-vulnerable-populations-a-study-protocol
#20
Marya Viorst Gwadz, Linda M Collins, Charles M Cleland, Noelle R Leonard, Leo Wilton, Monica Gandhi, R Scott Braithwaite, David C Perlman, Alexandra Kutnick, Amanda S Ritchie
BACKGROUND: More than half of persons living with HIV (PLWH) in the United States are insufficiently engaged in HIV primary care and not taking antiretroviral therapy (ART), mainly African Americans/Blacks and Hispanics. In the proposed project, a potent and innovative research methodology, the multiphase optimization strategy (MOST), will be employed to develop a highly efficacious, efficient, scalable, and cost-effective intervention to increase engagement along the HIV care continuum...
May 4, 2017: BMC Public Health
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