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https://www.readbyqxmd.com/read/29147885/proceedings-of-the-2017-isev-symposium-on-hiv-neurohiv-drug-abuse-evs
#1
Guoku Hu, Sowmya Yelamanchili, Fatah Kashanchi, Norman Haughey, Vincent C Bond, Kenneth W Witwer, Lynn Pulliam, Shilpa Buch
Despite the success of combination antiretroviral therapy (cART), there is increased prevalence of HIV-associated neurocognitive disorders (HAND) in HIV-1-infected individuals on cART, which poses a major health care challenge. Adding further complexity to this long-term antiretroviral use is the comorbidity with drugs of abuse such as morphine, cocaine, and methamphetamine, which can in turn, exacerbate neurologic and cognitive deficits associated with HAND. Furthermore, HIV proteins, such as the transactivator of transcription (Tat) and the envelope protein (gp120), as well as antiretrovirals themselves can also contribute to the progression of neurodegeneration underlying HAND...
November 16, 2017: Journal of Neurovirology
https://www.readbyqxmd.com/read/29140873/experienced-hiv-related-stigma-in-healthcare-and-community-settings-mediated-associations-with-psychosocial-and-health-outcomes
#2
Emma Sophia Kay, Whitney S Rice, Kaylee B Crockett, Ghislaine C Atkins, D Scott Batey, Bulent Turan
INTRODUCTION: There are multiple dimensions of HIV-related stigma that can compromise the mental and physical health of people living with HIV (PLWH). We focused on the dimension of experienced stigma, defined as exposure to acts of discrimination, devaluation, and prejudice, and investigated its relationship with HIV health and psychosocial outcomes. METHODS: We examined associations between experienced stigma in the community and healthcare settings and psychosocial and health outcomes for PLWH (N=203) receiving care at an urban HIV clinic in the Southeastern United States...
November 13, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29131878/association-of-brain-structure-changes-and-cognitive-function-with-combination-antiretroviral-therapy-in-hiv-positive-individuals
#3
Ryan Sanford, Lesley K Fellows, Beau M Ances, D Louis Collins
Importance: Despite the introduction of combination antiretroviral therapy (cART), HIV-associated neurocognitive disorders continue to be a problem for treated HIV-positive individuals. The cause of this impairment remains unclear. Objective: To determine if detectable brain changes occur during a 2-year period in HIV-positive individuals who were aviremic and treated with cART. Design, Setting, and Participants: In this longitudinal case-control study, participants underwent neuroimaging and neuropsychological assessment approximately 2 years apart...
November 13, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29131457/neurodevelopmental-outcome-of-hiv-exposed-but-uninfected-infants-in-the-mother-and-infants-health-study-cape-town-south-africa
#4
Priscilla E Springer, Amy L Slogrove, Barbara Laughton, Julie A Bettinger, Henriëtte H Saunders, Christopher D Molteno, Mariana Kruger
OBJECTIVES: To compare neurodevelopmental outcomes of HIV-exposed uninfected (HEU) and HIV-unexposed uninfected (HUU) infants in a peri-urban South African population. HEU infants living in Africa face unique biological and environmental risks but uncertainty remains regarding their neurodevelopmen-tal outcome. This is partly due to lack of well-matched HUU comparison groups needed to adjust for confounding factors. METHODS: This was a prospective cohort study of infants enrolled at birth from a low- risk midwife obstetric facility...
November 13, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29112532/speech-in-noise-perception-as-a-marker-of-cognitive-impairment-in-hiv-infection
#5
Yi Zhan, Abigail M Fellows, Tangkai Qi, Odile H Clavier, Sigfrid D Soli, Xiudong Shi, Jiang Gui, Yuxin Shi, Jay C Buckey
OBJECTIVES: Human immunodeficiency virus positive (HIV+) individuals report hearing difficulties, but standard audiological tests show no, or small, changes in peripheral hearing ability. The hearing complaints may reflect central nervous system (CNS) auditory processing deficits, rather than middle or inner ear problems, and may result from CNS damage due to HIV infection or treatment. If central auditory task performance and cognitive deficits in HIV+ individuals are shown to be related, then central auditory tests might serve as a "window" into CNS function in these patients...
November 4, 2017: Ear and Hearing
https://www.readbyqxmd.com/read/29112116/application-of-chitosan-chitooligosaccharide-and-their-derivatives-in-the-treatment-of-alzheimer-s-disease
#6
REVIEW
Qian-Qian Ouyang, Shannon Zhao, Si-Dong Li, Cai Song
Classic hypotheses of Alzheimer's disease (AD) include cholinergic neuron death, acetylcholine (ACh) deficiency, metal ion dynamic equilibrium disorder, and deposition of amyloid and tau. Increased evidence suggests neuroinflammation and oxidative stress may cause AD. However, none of these factors induces AD independently, but they are all associated with the formation of Aβ and tau proteins. Current clinical treatments based on ACh deficiency can only temporarily relieve symptoms, accompanied with many side-effects...
November 7, 2017: Marine Drugs
https://www.readbyqxmd.com/read/29112069/neuropsychological-performance-in-african-children-with-hiv-enrolled-in-a-multi-site-anti-retroviral-clinical-trial
#7
Michael J Boivin, Linda Barlow-Mosha, Miriam Chernoff, Barbara Laughton, Bonnie Zimmer, Celeste Joyce, Mutsa Bwakura-Dangarembizi, Mmule Ratswana, Nasreen Abrahams, Lee Fairlie, Hermien Gous, Portia Kamthunzi, Katie McCarthy, Itziar Familiar-Lopez, Patrick Jean-Phillippe, Joan Coetzee, Avy Violari, Mark Cotton, Paul Palumbo
OBJECTIVE & DESIGN: Children with HIV infection (HIV+) are at neuropsychological risk, but few studies have evaluated this at multiple sites in low and middle income countries (LMICs). We compared neuropsychological outcomes at enrollment (>5 yrs age) among HIV+, HIV-uninfected perinatally-exposed (HEU), and HIV unexposed (HU) children from 4 sub-Saharan countries. METHODS: IMPAACT P1060 compared Nevirapine (NVP) versus Lopinavir/Ritonavir (LPVr)-based ART in HIV-infected children 6 to 35 months of age...
November 2, 2017: AIDS
https://www.readbyqxmd.com/read/29112063/sex-based-differences-in-neurocognitive-functioning-in-hiv-infected-young-adults
#8
Ruxandra Burlacu, Anya Umlauf, Anca Luca, Sara Gianella, Roxana Radoi, Simona M Ruta, Thomas D Marcotte, Luminita Ene, Cristian L Achim
INTRODUCTION: Sex differences in cognition of HIV positive (HIV+) patients are controversial. We aimed to investigate the relationship between cognition, HIV status, and sex, in a highly homogenous cohort of young Romanians parenterally infected during early childhood. METHODS: 250 HIV+ participants were compared to age-matched HIV negative (HIV-) controls (n = 72) in a cross-sectional study. After standardized neurocognitive, psychological testing and medical evaluation, linear regression was used to assess the effect of sex and HIV on neurocognitive outcomes...
November 2, 2017: AIDS
https://www.readbyqxmd.com/read/29108003/schistosoma-other-helminth-infections-and-associated-risk-factors-in-preschool-aged-children-in-urban-tanzania
#9
Khadija Said, Jerry Hella, Stefanie Knopp, Tatu Nassoro, Neema Shija, Fatma Aziz, Francis Mhimbira, Christian Schindler, Upendo Mwingira, Anna M Mandalakas, Karim Manji, Marcel Tanner, Jürg Utzinger, Lukas Fenner
BACKGROUND: Despite the high prevalence of helminth infections among preschool-aged children, control programs in sub-Saharan countries primarily focus on school-aged populations. We assessed the prevalence of helminth infections and determined risk factors for infection among preschool-aged children in the urban setting of Dar es Salaam, Tanzania. METHODOLOGY: Starting in October 2015, we conducted a 12-month prospective study among tuberculosis (TB)-exposed children under the age of 5 years and unexposed controls from neighboring households...
November 6, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29099110/deterioro-cognitivo-en-adultos-mayores-con-vih-sida-y-s%C3%A3-ndrome-de-fragilidad
#10
Alfonso Zamudio-Rodríguez, Sara Aguilar-Navarro, José Alberto Avila-Funes
In 2014, 17% of newly diagnosed HIV infection cases in the United States were made in people over 50 years of age; actually, it is expected that in the near future this population group will be the most affected. This epidemiological change can be explained by the increased incidence of HIV infection in people over 50 years, but also by its higher prevalence due to treatment advances. As HIV infection has become a chronic one, new challenges have emerged. For instance, early-onset "geriatric syndromes," such as frailty, have been recognized in these patients...
2017: Gaceta Médica de México
https://www.readbyqxmd.com/read/29081720/effects-of-recent-alcohol-consumption-level-on-neurocognitive-performance-in-hiv-individuals
#11
Kara R Douglas-Newman, Rachel V Smith, Mary V Spiers, Timothy Pond, Henry R Kranzler
OBJECTIVES: Although HIV+ individuals may be at increased risk of alcohol-related cognitive impairment, the relations between drinking level and cognitive performance in these individuals are not well understood. We examined whether higher levels of recent drinking in HIV+ individuals were associated with poorer cognitive performance, particularly in executive functioning (EF) and memory. METHODS: We administered a comprehensive cognitive battery to 120 seropositive subjects (101 men) who reported alcohol consumption in the preceding 90 days...
September 2017: Addictive Disorders & Their Treatment
https://www.readbyqxmd.com/read/29080244/impaired-patient-reported-outcomes-persist-in-hiv-hcv-co-infected-patients-and-in-cirrhotic-patients-despite-hcv-clearance
#12
Fabienne Marcellin, Philippe Morlat, Linda Wittkop, Dominique Salmon-Ceron, Maria Patrizia Carrieri
Dirks et al.(1) 's recent study provides greater insight into the neuropsychiatric symptoms experienced by HCV infected patients and questions how these symptoms are associated with HCV clearance. The authors show that in HCV infected patients with mild liver disease, none of the following outcomes depend on HCV clearance: cognitive function, mood alteration, health-related quality of life (HRQL) and fatigue (FIS scores). However, these results may not be generalizable to HIV-HCV co-infected patients and cirrhotic patients, who were excluded from the study and who are generally more concerned by fatigue and neuropsychiatric symptoms...
October 27, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29080122/sex-differences-in-select-non-communicable-hiv-associated-comorbidities-exploring-the-role-of-systemic-immune-activation-inflammation
#13
REVIEW
Avanthi Raghavan, Dodie E Rimmelin, Kathleen V Fitch, Markella V Zanni
PURPOSE OF THE REVIEW: The goals of this review are to (1) explore HIV-associated cardiovascular disease (CVD), neurocognitive impairment, and non-AIDS-defining cancers (NADC) as heterogeneous model disease states fuelled in part by systemic immune activation/inflammation; (2) consider sex differences in the epidemiology of these diseases in both high-resource and lower-resource settings; and (3) examine biological and environmental factors which may contribute to heightened systemic immune activation/inflammation specifically among women living with HIV (WLHIV)...
December 2017: Current HIV/AIDS Reports
https://www.readbyqxmd.com/read/29073834/theory-based-analysis-of-interest-in-an-hiv-vaccine-for-reasons-indicative-of-risk-compensation-among-african-american-women
#14
Julia E Painter, Brandie S Temple, Laura A Woods, Carrie Cwiak, Lisa B Haddad, Mark J Mulligan, Ralph J DiClemente
Licensure of an HIV vaccine could reduce or eliminate HIV among vulnerable populations. However, vaccine effectiveness could be undermined by risk compensation (RC), defined by an increase in risky behavior due to a belief that the vaccine will confer protection. Interest in an HIV vaccine for reasons indicative of RC may serve as an indicator of actual RC in a postlicensure era. This study assessed factors associated with interest in an HIV vaccine for reasons indicative of RC among African American women aged 18 to 55 years, recruited from a hospital-based family planning clinic in Atlanta, Georgia ( N = 321)...
October 1, 2017: Health Education & Behavior: the Official Publication of the Society for Public Health Education
https://www.readbyqxmd.com/read/29072305/life-history-theory-hypotheses-on-child-growth-potential-implications-for-short-and-long-term-child-growth-development-and-health
#15
EDITORIAL
Rihlat Said-Mohamed, John M Pettifor, Shane A Norris
Life history theory integrates ecological, physiological, and molecular layers within an evolutionary framework to understand organisms' strategies to optimize survival and reproduction. Two life history hypotheses and their implications for child growth, development, and health (illustrated in the South African context) are reviewed here. One hypothesis suggests that there is an energy trade-off between linear growth and brain growth. Undernutrition in infancy and childhood may trigger adaptive physiological mechanisms prioritizing the brain at the expense of body growth...
October 26, 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/29067834/mindfulness-instruction-for-hiv-infected-youth-a-randomized-controlled-trial
#16
Lindsey Webb, Carisa Perry-Parrish, Jonathan Ellen, Erica Sibinga
HIV-infected youth experience many stressors, including stress related to their illness, which can negatively impact their mental and physical health. Therefore, there is a significant need to identify potentially effective interventions to improve stress management, coping, and self-regulation. The object of the study was to assess the effect of a mindfulness-based stress reduction (MBSR) program compared to an active control group on psychological symptoms and HIV disease management in youth utilizing a randomized controlled trial...
October 25, 2017: AIDS Care
https://www.readbyqxmd.com/read/29066542/mechanisms-of-cns-viral-seeding-by-hiv-cd14-cd16-monocytes-establishment-and-reseeding-of-viral-reservoirs-contributing-to-hiv-associated-neurocognitive-disorders
#17
Mike Veenstra, Rosiris León-Rivera, Ming Li, Lucio Gama, Janice E Clements, Joan W Berman
HIV reservoirs persist despite antiretroviral therapy (ART) and are established within a few days after infection. Infected myeloid cells in the central nervous system (CNS) may contribute to the establishment of a CNS viral reservoir. The mature CD14(+) CD16(+) monocyte subset enters the CNS in response to chemokines, including CCL2. Entry of infected CD14(+) CD16(+) monocytes may lead to infection of other CNS cells, including macrophages or microglia and astrocytes, and to release of neurotoxic early viral proteins and additional cytokines...
October 24, 2017: MBio
https://www.readbyqxmd.com/read/29063516/paroxetine-and-fluconazole-therapy-for-hiv-associated-neurocognitive-impairment-results-from-a-double-blind-placebo-controlled-trial
#18
Ned Sacktor, Richard L Skolasky, Richard Moxley, Sheng Wang, Michelle M Mielke, Cynthia Munro, Joseph Steiner, Avindra Nath, Norman Haughey, Justin McArthur
Paroxetine and fluconazole have neuroprotective effects in an in vitro model of HIV protein-mediated neuronal injury. This study evaluated the safety, tolerability, and efficacy of both paroxetine and fluconazole for the treatment of HIV-associated neurocognitive disorder (HAND). A 24-week randomized double-blind, placebo-controlled 2 × 2 factorial design study was used. HIV+ individuals with cognitive impairment were enrolled in the 24-week trial. Participants were randomly assigned to one of four groups: (1) paroxetine 20 mg/day, (2) fluconazole 100 mg every 12 h, (3) paroxetine and fluconazole, or (4) placebo...
October 23, 2017: Journal of Neurovirology
https://www.readbyqxmd.com/read/29063513/variability-in-c-reactive-protein-is-associated-with-cognitive-impairment-in-women-living-with-and-without-hiv-a-longitudinal-study
#19
Leah H Rubin, Lorie Benning, Sheila M Keating, Philip J Norris, Jane Burke-Miller, Antonia Savarese, Krithika N Kumanan, Saria Awadalla, Gayle Springer, Kathyrn Anastos, Mary Young, Joel Milam, Victor G Valcour, Kathleen M Weber, Pauline M Maki
Despite the availability of effective antiretroviral therapies, cognitive impairment (CI) remains prevalent in HIV-infected (HIV+) individuals. Evidence from primarily cross-sectional studies, in predominantly male samples, implicates monocyte- and macrophage-driven inflammatory processes linked to HIV-associated CI. Thus, peripheral systemic inflammatory markers may be clinically useful biomarkers in tracking HIV-associated CI. Given sex differences in immune function, we focused here on whether mean and intra-individual variability in inflammatory marker-predicted CI in HIV+ and HIV- women...
October 23, 2017: Journal of Neurovirology
https://www.readbyqxmd.com/read/29061509/monoacylglycerol-lipase-inhibitor-jzl184-prevents-hiv-1-gp120-induced-synapse-loss-by-altering-endocannabinoid-signaling
#20
Xinwen Zhang, Stanley A Thayer
Monoacylglycerol lipase (MGL) hydrolyzes 2-arachidonoylglycerol to arachidonic acid and glycerol. Inhibition of MGL may attenuate neuroinflammation by enhancing endocannabinoid signaling and decreasing prostaglandin (PG) production. Almost half of HIV infected individuals are afflicted with HIV-associated neurocognitive disorder (HAND), a neuroinflammatory disease in which cognitive decline correlates with synapse loss. HIV infected cells shed the envelope protein gp120 which is a potent neurotoxin that induces synapse loss...
October 20, 2017: Neuropharmacology
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