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https://www.readbyqxmd.com/read/29350143/adenovirus-type-4-respiratory-infections-among-civilian-adults-northeastern-united-states-2011-20151
#1
Adriana E Kajon, Daryl M Lamson, Camden R Bair, Xiaoyan Lu, Marie L Landry, Marilyn Menegus, Dean D Erdman, Kirsten St George
Human adenovirus type 4 (HAdV-4) is most commonly isolated in military settings. We conducted detailed molecular characterization on 36 HAdV-4 isolates recovered from civilian adults with acute respiratory disease (ARD) in the northeastern United States during 2011-2015. Specimens came from college students, residents of long-term care facilities or nursing homes, a cancer patient, and young adults without co-morbidities. HAdV-4 genome types 4a1 and 4a2, the variants most frequently detected among US military recruits in basic training before the restoration of vaccination protocols, were isolated in most cases...
February 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29298413/a-recombinant-antibody-expressing-influenza-virus-delays-tumor-growth-in-a-mouse-model
#2
Jennifer R Hamilton, Gayathri Vijayakumar, Peter Palese
Influenza A virus (IAV) has shown promise as an oncolytic agent. To improve IAV as an oncolytic virus, we sought to design a transgenic virus expressing an immune checkpoint-inhibiting antibody during the viral life cycle. To test whether it was possible to express an antibody during infection, an influenza virus was constructed encoding the heavy chain of an antibody on the PB1 segment and the light chain of an antibody on the PA segment. This antibody-expressing IAV grows to high titers, and the antibodies secreted from infected cells exhibit comparable functionality with hybridoma-produced antibodies...
January 2, 2018: Cell Reports
https://www.readbyqxmd.com/read/29285119/trichosanthin-enhances-the-antitumor-effect-of-gemcitabine-in-non-small-cell-lung-cancer-via-inhibition-of-the-pi3k-akt-pathway
#3
Naren Tuya, Yadi Wang, Lanmei Tong, Weishi Gao, Rong Yu, Liying Xue
Gemcitabine (GEMZ) is the first-line therapy used against non-small cell lung cancer (NSCLC), and studies have focused on investigating the potential effects of agents combined with GEMZ to enhance the anticancer efficacy in NSCLC. Previous studies have reported that trichosanthin (TCS) has various physiological and pharmacological effects, including anti-human influenza virus enzymes, inhibition of protein synthesis and antitumor activity. The purpose of the present study was to investigate if TCS enhanced the antitumor effects of GEMZ in NSCLC...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29277629/patterns-and-correlates-of-cervical-cancer-screening-initiation-in-a-large-integrated-healthcare-system
#4
Tracy A Becerra-Culqui, Neal M Lonky, Qiaoling Chen, Chun R Chao
BACKGROUND: The latest 2012 United States Preventive Services Task Force cervical cancer screening guidelines recommended screening initiation at age 21 years. Little is known about the cervical cancer screening initiation practices in the community, and whether there are critical gaps with respect to adherence to current clinical guidelines. Despite an overall decline in cervical cancer incidence across women of all ages, the incidence rate has not declined among 24-25 year-olds between 2000 (2...
December 22, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29200182/invasive-haemophilus-influenzae-type-b-hib-infections-in-children-with-cancer-in-the-era-of-infant-hib-immunization-programs-1991-2014-a-report-from-the-canadian-immunization-monitoring-program-active
#5
Joanne McNair, Alyssa Smith, Julie A Bettinger, Wendy Vaudry, Ben Tan, Shalini Desai, Scott A Halperin, Karina A Top
We studied the epidemiology of Haemophilus influenzae type b (Hib) infections among children with cancer admitted to Canadian pediatric hospitals. From 1991-2014, 13 cases among children with cancer were identified through active surveillance. Average age was 6.7 years. Six of 7 cases eligible for infant immunization were age-appropriately immunized (vaccine failures). Children with cancer may benefit from booster Hib immunization.
December 1, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29199226/imaging-of-sialidase-activity-and-its-clinical-application
#6
Takashi Suzuki
Sialidase releases sialic acid residues from the ends of sugar chains. The sialidases are involved in many physiological processes including cell differentiation and proliferation and immune function as well as pathophysiological conditions such as various human cancers and infections. Therefore visualization of sialidase activities with high sensitivity could provide valuable insights into these isozyme's activity. We developed novel fluorescent sialidase substrates, 2-benzothiazol-2-yl-phenol derivatives-based N-acetylneuraminic acid (Neu5Ac) (BTP-Neu5Ac) substrates, for highly sensitive and specific visualization of sialidase activity in living mammalian tissues and virus-infected cells...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29190829/a-comprehensive-analysis-of-breast-cancer-microbiota-and-host-gene-expression
#7
Kevin J Thompson, James N Ingle, Xiaojia Tang, Nicholas Chia, Patricio R Jeraldo, Marina R Walther-Antonio, Karunya K Kandimalla, Stephen Johnson, Janet Z Yao, Sean C Harrington, Vera J Suman, Liewei Wang, Richard L Weinshilboum, Judy C Boughey, Jean-Pierre Kocher, Heidi Nelson, Matthew P Goetz, Krishna R Kalari
The inflammatory tumoral-immune response alters the physiology of the tumor microenvironment, which may attenuate genomic instability. In addition to inducing inflammatory immune responses, several pathogenic bacteria produce genotoxins. However the extent of microbial contribution to the tumor microenvironment biology remains unknown. We utilized The Cancer Genome Atlas, (TCGA) breast cancer data to perform a novel experiment utilizing unmapped and mapped RNA sequencing read evidence to minimize laboratory costs and effort...
2017: PloS One
https://www.readbyqxmd.com/read/29188128/influenza-a-virus-infection-damages-zebrafish-skeletal-muscle-and-exacerbates-disease-in-zebrafish-modeling-duchenne-muscular-dystrophy
#8
Michelle Goody, Denise Jurczyszak, Carol Kim, Clarissa Henry
INTRODUCTION: Both genetic and infectious diseases can result in skeletal muscle degeneration, inflammation, pain, and/or weakness. Duchenne muscular dystrophy (DMD) is the most common congenital muscle disease. DMD causes progressive muscle wasting due to mutations in Dystrophin. Influenza A and B viruses are frequently associated with muscle complications, especially in children. Infections activate an immune response and immunosuppressant drugs reduce DMD symptoms. These data suggest that the immune system may contribute to muscle pathology...
October 25, 2017: PLoS Currents
https://www.readbyqxmd.com/read/29173310/the-effectiveness-of-trivalent-inactivated-influenza-vaccine-in-children-with-acute-leukemia
#9
April Sykes, Elsie Gerhardt, Li Tang, Elisabeth E Adderson
OBJECTIVE: The objective of this study was to determine the effectiveness of trivalent inactivated influenza vaccine (TIV) for the prevention of laboratory-confirmed influenza and influenza-like illnesses (ILI) among children and adolescents receiving therapy for acute leukemia. STUDY DESIGN: A retrospective review of the demographic and clinical characteristics of 498 patients at a pediatric cancer center who received therapy for acute leukemia during 3 successive influenza seasons (2010-2011 through 2012-2013)...
December 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29167460/early-vaccination-protects-against-childhood-leukemia-a-systematic-review-and-meta-analysis
#10
Mostafa Ebraheem Morra, Nguyen Dang Kien, Ahmed Elmaraezy, Omar Ayman M Abdelaziz, Ahmed Lotfy Elsayed, Oday Halhouli, Ahmed Mosaad Montasr, Tran Le-Huy Vu, Chau Ho, Amr Sayed Foly, Anh Phan Phi, Wessam Magdy Abdullah, Marina Mikhail, Elizabeth Milne, Kenji Hirayama, Nguyen Tien Huy
Leukemia is the most commonly diagnosed childhood cancer, although its etiology is still largely unknown. Growing evidence supports a role for infection in the etiology of acute lymphocytic leukemia (ALL), and the involvement of the immune system suggests that vaccination may also play a role. However, the findings presented in the published literature are inconsistent. Therefore, we conducted a PRISMA systematic review and meta-analysis. 14 studies were identified and meta-analyzed. Vaccinations studied comprised Bacillus Calmette-Guérin (BCG) vaccine, Triple vaccine, Hepatitis B vaccine (HBV), Polio, Measles, Rubella, Mumps, trivalent MMR vaccine and Haemophilus influenza type B (HiB) vaccine...
November 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29163402/pharmacological-induction-of-heme-oxygenase-1-impairs-nuclear-accumulation-of-herpes-simplex-virus-capsids-upon-infection
#11
Francisco J Ibáñez, Mónica A Farías, Angello Retamal-Díaz, Janyra A Espinoza, Alexis M Kalergis, Pablo A González
Heme oxygenase-1 (HO-1) is an inducible enzyme that is expressed in response to physical and chemical stresses, such as ultraviolet radiation, hyperthermia, hypoxia, reactive oxygen species (ROS), as well as cytokines, among others. Its activity can be positively modulated by cobalt protoporphyrin (CoPP) and negatively by tin protoporphirin (SnPP). Once induced, HO-1 degrades iron-containing heme into ferrous iron (Fe(2+)), carbon monoxide (CO) and biliverdin. Importantly, numerous products of HO-1 are cytoprotective with anti-apoptotic, anti-oxidant, anti-inflammatory, and anti-cancer effects...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29151581/human-pbmc-transferred-murine-mhc-class-i-ii-deficient-nog-mice-enable-long-term-evaluation-of-human-immune-responses
#12
Tomonori Yaguchi, Asuka Kobayashi, Takashi Inozume, Kenji Morii, Haruna Nagumo, Hiroshi Nishio, Takashi Iwata, Yuyo Ka, Ikumi Katano, Ryoji Ito, Mamoru Ito, Yutaka Kawakami
Immunodeficient mice engrafted with human peripheral blood cells are promising tools for in vivo analysis of human patient individual immune responses. However, when human peripheral blood mononuclear cells (PBMCs) are transferred into NOG (NOD/Shi-scid, IL-2rg(null)) mice, severe graft versus host disease (GVHD) hinders long term detailed analysis. Administration of human PBMCs into newly developed murine MHC class I- and class II-deficient NOG (NOG-dKO; NOG- Iab, B2m-double-knockout) mice showed sufficient engraftment of human immune cells with little sign of GVHD...
November 20, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29141918/wild-microbiome-stems-tumorigenesis-in-lab-mice
#13
(no author information available yet)
Replacing laboratory mice's gut microbiomes with the microbial communities of their wild counterparts alters the lab animals' immune systems and boosts their resistance to colorectal cancer development and influenza.
November 15, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/29071308/a-text-mining-framework-for-supporting-systematic-reviews
#14
Dingcheng Li, Zhen Wang, Liwei Wang, Sunghwan Sohn, Feichen Shen, Mohammad Hassan Murad, Hongfang Liu
Systematic reviews (SRs) involve the identification, appraisal, and synthesis of all relevant studies for focused questions in a structured reproducible manner. High-quality SRs follow strict procedures and require significant resources and time. We investigated advanced text-mining approaches to reduce the burden associated with abstract screening in SRs and provide high-level information summary. A text-mining SR supporting framework consisting of three self-defined semantics-based ranking metrics was proposed, including keyword relevance, indexed-term relevance and topic relevance...
November 2016: American Journal of Information Management
https://www.readbyqxmd.com/read/29067097/highly-pathogenic-avian-influenza-a-virus-h5n1-non-structural-protein-1-is-associated-with-apoptotic-activation-of-the-intrinsic-mitochondrial-pathway
#15
Qian Bian, Jing Lu, Li Zhang, Ying Chi, Yan Li, Hongxiong Guo
Outbreaks of avian influenza A (H5N1) virus infection have significant health and economic consequences. Non-structural protein 1 (NS1) is an essential virulence factor of the highly pathogenic H5N1 avian influenza virus and of the apoptosis associated with the pathogenesis of H5N1. Previous studies have revealed that the NS1 protein is able to induce apoptosis via an extrinsic pathway. However, it remains unclear whether the intrinsic pathway is also associated with this apoptosis. The present study used a clone of the NS1 gene from avian influenza A/Jiangsu/1/2007 and observed the localization of the NS1 protein and cytochrome c release from mitochondria and the change of mitochondrial membrane potential (MMP) in lung cancer cells...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29051018/access-to-employee-wellness-programs-and-use-of-preventive-care-services-among-u-s-adults
#16
Oluwaseyi O Isehunwa, Erik L Carlton, Yang Wang, Yu Jiang, Satish Kedia, Cyril F Chang, Daniel Fijabi, Soumitra S Bhuyan
INTRODUCTION: There is little research at the national level on access to employee wellness programs and the use of preventive care services. This study examined the use of seven preventive care services among U.S working adults with access to employee wellness programs. METHODS: The study population comprised 17,699 working adults aged ≥18 years, obtained from the 2015 National Health Interview Survey. Multivariate logistic regression models examined the relationship between access to employee wellness programs and use of seven preventive care services: influenza vaccination, blood pressure check, diabetes check, cholesterol check, Pap smear test, mammogram, and colon cancer screening...
October 16, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29035180/ten-year-trends-in-preventive-service-use-before-and-after-prostate-cancer-diagnosis-a-comparison-with-noncancer-controls
#17
Lauren P Wallner, Jeffrey M Slezak, Ronald K Loo, Roshan Bastani, Steven J Jacobsen
CONTEXT: Few studies have assessed the longer-term quality of preventive care in prostate cancer (PCa) survivors. OBJECTIVE: To compare the rates of preventive services among PCa survivors five years before and after diagnosis, to men without PCa. DESIGN: Men enrolled in Kaiser Permanente Southern California with newly diagnosed PCa (2002-2008) were matched 1:1 to men without a PCa diagnosis on age, race, and timing of prostate-specific antigen test (N = 31,180)...
2017: Permanente Journal
https://www.readbyqxmd.com/read/28988534/biochemical-variations-in-cytolytic-activity-of-ortho-and-paramyxoviruses-in-human-lung-tumor-cell-culture
#18
O P Zhirnov
Human lung cancer cells (Calu-3 line) were studied for the development of apoptosis, necrosis, and autophagy in response to infection with ortho- and paramyxoviruses. Biochemical pathways underlying various mechanisms of cell death differed for different viruses. When infected with murine Sendai paramyxovirus, Calu-3 cells demonstrated typical necrotic features such as cell swelling (but not shrinkage), lack of chromatin DNA laddering, of caspase 3 and 8 activation, and of apoptotic cleavage of poly(ADP-ribose) polymerase (PARP) protein; an activation of antiapoptotic protein kinase Akt was also revealed...
September 2017: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/28981699/individual-specific-edge-network-analysis-for-disease-prediction
#19
Xiangtian Yu, Jingsong Zhang, Shaoyan Sun, Xin Zhou, Tao Zeng, Luonan Chen
Predicting pre-disease state or tipping point just before irreversible deterioration of health is a difficult task. Edge-network analysis (ENA) with dynamic network biomarker (DNB) theory opens a new way to study this problem by exploring rich dynamical and high-dimensional information of omics data. Although theoretically ENA has the ability to identify the pre-disease state during the disease progression, it requires multiple samples for such prediction on each individual, which are generally not available in clinical practice, thus limiting its applications in personalized medicine...
November 16, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28882967/influenza-among-breast-cancer-survivors-in-south-korea-a-nationwide-population-based-study
#20
Jaesung Heo, Mison Chun, Young-Taek Oh, O Kyu Noh, Logyoung Kim
BACKGROUND/AIM: In this study, we analyzed the prevalence of influenza disease in breast cancer survivors using claims data from the Health Insurance Review and Assessment Service (HIRA) in South Korea. PATIENTS AND METHODS: We defined influenza among a nationwide cohort of 87,843 patients who were diagnosed with breast cancer and underwent surgery from January 1, 2010 to December 31, 2014, based on HIRA claim data. Descriptive statistics were calculated to estimate the frequency of influenza disease using diagnostic code and utilization pattern at medical institutions...
September 2017: In Vivo
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