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https://www.readbyqxmd.com/read/29774014/oral-microbiota-community-dynamics-associated-with-oral-squamous-cell-carcinoma-staging
#1
Chia-Yu Yang, Yuan-Ming Yeh, Hai-Ying Yu, Chia-Yin Chin, Chia-Wei Hsu, Hsuan Liu, Po-Jung Huang, Song-Nian Hu, Chun-Ta Liao, Kai-Ping Chang, Yu-Liang Chang
Oral squamous cell carcinoma (OSCC) is a highly aggressive cancer and the fourth leading malignancy among males in Taiwan. Some pathogenic bacteria are associated with periodontitis and oral cancer. However, the comprehensive profile of the oral microbiome during the cancer's progression from the early stage to the late stage is still unclear. We profiled the oral microbiota and identified bacteria biomarkers associated with OSCC. The microbiota of an oral rinse from 51 healthy individuals and 197 OSCC patients at different stages were investigated using 16S rRNA V3V4 amplicon sequencing, followed by bioinformatics and statistical analyses...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29773491/association-between-number-of-preventive-care-guidelines-and-preventive-care-utilization-by-patients
#2
Glen B Taksler, Elizabeth R Pfoh, Kurt C Stange, Michael B Rothberg
INTRODUCTION: The number of preventive care guidelines is rapidly increasing. It is unknown whether the number of guideline-recommended preventive services is associated with utilization. METHODS: The authors used Poisson regression of 390,778 person-years of electronic medical records data from 2008 to 2015, in 80,773 individuals aged 50-75 years. Analyses considered eligibility for 11 preventive services most closely associated with guidelines: tobacco cessation; control of obesity, hypertension, lipids, or blood glucose; influenza vaccination; and screening for breast, cervical, or colorectal cancers, abdominal aortic aneurysm, or osteoporosis...
May 8, 2018: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29769722/bystander-cd8-t-cells-are-abundant-and-phenotypically-distinct-in-human-tumour-infiltrates
#3
Yannick Simoni, Etienne Becht, Michael Fehlings, Chiew Yee Loh, Si-Lin Koo, Karen Wei Weng Teng, Joe Poh Sheng Yeong, Rahul Nahar, Tong Zhang, Hassen Kared, Kaibo Duan, Nicholas Ang, Michael Poidinger, Yin Yeng Lee, Anis Larbi, Alexis J Khng, Emile Tan, Cherylin Fu, Ronnie Mathew, Melissa Teo, Wan Teck Lim, Chee Keong Toh, Boon-Hean Ong, Tina Koh, Axel M Hillmer, Angela Takano, Tony Kiat Hon Lim, Eng Huat Tan, Weiwei Zhai, Daniel S W Tan, Iain Beehuat Tan, Evan W Newell
Various forms of immunotherapy, such as checkpoint blockade immunotherapy, are proving to be effective at restoring T cell-mediated immune responses that can lead to marked and sustained clinical responses, but only in some patients and cancer types1-4 . Patients and tumours may respond unpredictably to immunotherapy partly owing to heterogeneity of the immune composition and phenotypic profiles of tumour-infiltrating lymphocytes (TILs) within individual tumours and between patients5,6 . Although there is evidence that tumour-mutation-derived neoantigen-specific T cells play a role in tumour control2,4,7-10 , in most cases the antigen specificities of phenotypically diverse tumour-infiltrating T cells are largely unknown...
May 16, 2018: Nature
https://www.readbyqxmd.com/read/29769253/effectiveness-of-23-valent-pneumococcal-polysaccharide-vaccine-on-elderly-long-term-cancer-survivors-a-population-based-propensity-score-matched-cohort-study
#4
Wen-Yen Chiou, Moon-Sing Lee, Shih-Kai Hung, Hon-Yi Lin, Yuan-Chen Lo, Feng-Chun Hsu, Shiang-Jiun Tsai, Chung-Yi Li
OBJECTIVE: The Advisory Committee on Immunization Practices in 2012 recommended the 23-valent pneumococcal polysaccharide vaccine (PPSV23) for adults with high risk of pneumonia. However, its effectiveness in cancer survivors has not been investigated. Our aim was to investigate the effectiveness of PPSV23 in these patients. DESIGN: Population-based matched cohort study. SETTING: Claim data were obtained from 1 million people registered with the National Health Insurance Research Database in 1996, and followed to 2010...
May 16, 2018: BMJ Open
https://www.readbyqxmd.com/read/29721377/oncolytic-influenza-virus-infection-restores-immunocompetence-of-lung-tumor-associated-alveolar-macrophages
#5
Dörthe Masemann, Katharina Köther, Meike Kuhlencord, Georg Varga, Johannes Roth, Brian Dennis Lichty, Ulf Rüdiger Rapp, Viktor Wixler, Stephan Ludwig
Non-small-cell lung cancer (NSCLC) is the most frequent type of lung cancer and demonstrates high resistance to radiation and chemotherapy. These tumors evade immune system detection by promoting an immunosuppressive tumor microenvironment. Genetic analysis has revealed oncogenic activation of the Ras/Raf/MEK/ERK signaling pathway to be a hallmark of NSCLCs, which promotes influenza A virus (IAV) infection and replication in these cells. Thus, we aimed to unravel the oncolytic properties of IAV infection against NSCLCs in an immunocompetent model in vivo ...
2018: Oncoimmunology
https://www.readbyqxmd.com/read/29720976/carbonate-apatite-nanoparticles-act-as-potent-vaccine-adjuvant-delivery-vehicles-by-enhancing-cytokine-production-induced-by-encapsulated-cytosine-phosphate-guanine-oligodeoxynucleotides
#6
Hideki Takahashi, Kazuki Misato, Taiki Aoshi, Yasuyuki Yamamoto, Yui Kubota, Xin Wu, Etsushi Kuroda, Ken J Ishii, Hirofumi Yamamoto, Yasuo Yoshioka
Vaccine adjuvants that can induce not only antigen-specific antibody responses but also Th1-type immune responses and CD8+ cytotoxic T lymphocyte responses are needed for the development of vaccines against infectious diseases and cancer. Of many available adjuvants, oligodeoxynucleotides (ODNs) with unmethylated cytosine-phosphate-guanine (CpG) motifs are the most promising for inducing the necessary immune responses, and these adjuvants are currently under clinical trials in humans. However, the development of novel delivery vehicles that enhance the adjuvant effects of CpG ODNs, subsequently increasing the production of cytokines such as type-I interferons (IFNs), is highly desirable...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29708816/immune-response-to-influenza-vaccination-in-children-with-cancer
#7
Dimitrios Doganis, Athanasia Kafasi, Helen Dana, Nikolaos Spanakis, Margarita Baka, Apostolos Pourtsidis, Triantafyllia Sdogou, Artemis Vintila, Vaia Rafailidou, Panagiota Chantzi, Marina Servitzoglou, Despina Bouhoutsou, Maria Varvoutsi, Helen Kosmidis, Maria Tsolia
The aim of this study was to evaluate the ability of influenza immunization to evoke a protective immune response among children with cancer. We evaluated 75 children with cancer who received influenza vaccination. Hemagglutination Inhibition Antibody titers were determined before and after vaccination. The protective rates after vaccination were 79% for H1N1, 75% for H3N2 and 59% for influenza B virus whereas the seroconversion rates were 54%, 44% and 43% respectively. The differences pre- and post-vaccination were significant regardless the method which was used: seroprotection changes, seroconversion and geometric mean titers analyses...
April 30, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29704370/evaluation-of-healthy-fit-a-community-health-worker-model-to-address-hispanic-health-disparities
#8
Louis D Brown, Denise Vasquez, Jennifer J Salinas, Xiaohui Tang, Hector Balcázar
INTRODUCTION: Hispanics in the United States have disproportionately high rates of obesity, hypertension, and diabetes and poorer access to preventive health services. Healthy Fit uses community health workers to extend public health department infrastructure and address Hispanic health disparities related to cardiovascular disease and access to preventive health services. We evaluated the effectiveness of Healthy Fit in 1) reaching Hispanic Americans facing health disparities, and 2) helping participants access preventive health services and make behavior changes to improve heart health...
April 26, 2018: Preventing Chronic Disease
https://www.readbyqxmd.com/read/29680828/viral-pneumonia-etiologies-and-treatment
#9
Dima Dandachi, Maria C Rodriguez-Barradas
Viral pathogens are increasingly recognized as a cause of pneumonia, in immunocompetent patients and more commonly among immunocompromised. Viral pneumonia in adults could present as community-acquired pneumonia (CAP), ranging from mild disease to severe disease requiring hospital admission and mechanical ventilation. Moreover, the role of viruses in hospital-acquired pneumonia and ventilator-associated pneumonia as causative agents or as co-pathogens and the effect of virus detection on clinical outcome are being investigated...
April 20, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29671067/vaccinations-in-pediatric-kidney-transplant-recipients
#10
REVIEW
Thomas G Fox, Corina Nailescu
Pediatric kidney transplant (KT) candidates should be fully immunized according to routine childhood schedules using age-appropriate guidelines. Unfortunately, vaccination rates in KT candidates remain suboptimal. With the exception of influenza vaccine, vaccination after transplantation should be delayed 3-6 months to maximize immunogenicity. While most vaccinations in the KT recipient are administered by primary care physicians, there are specific schedule alterations in the cases of influenza, hepatitis B, pneumococcal, and meningococcal vaccinations; consequently, these vaccines are usually administered by transplant physicians...
April 18, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29666967/health-maintenance-in-inflammatory-bowel-disease
#11
REVIEW
Fazia A Mir, Sunanda V Kane
PURPOSE OF REVIEW: Patients with inflammatory bowel disease (IBD) are not receiving preventative care services at the same rate as the general population. IBD patients are at increased risk for infections, osteoporosis, and certain malignancies secondary to their disease and as they are on immunosuppressive therapy. They are a younger population and often times consider their gastroenterologist as their primary care physician. In this review, we discuss up-to-date evidence pertaining to vaccine-preventable illnesses in the immunosuppressed IBD patient, screening for bone health, cervical cancer, skin malignancies, psychological wellbeing, and smoking cessation...
April 17, 2018: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/29657714/non-typeable-haemophilus-influenzae-detection-in-the-lower-airways-of-patients-with-lung-cancer-and-chronic-obstructive-pulmonary-disease
#12
Krishna B Sriram, Amanda J Cox, Pathmanathan Sivakumaran, Maninder Singh, Annabelle M Watts, Nicholas P West, Allan W Cripps
Background: Chronic airway inflammation and hypersensitivity to bacterial infection may contribute to lung cancer pathogenesis. Previous studies have demonstrated that nontypeable Haemophilus influenzae (NTHi) is the most common colonizing bacteria in the lower airways of patients with COPD. The objective of this study was to determine the presence of NTHi and immunoglobulin concentrations in patients with lung cancer, COPD and controls. Methods: Serum and bronchial wash samples were collected from patients undergoing diagnostic bronchoscopy...
2018: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/29609192/the-burden-of-indirect-causes-of-maternal-morbidity-and-mortality-in-the-process-of-obstetric-transition-a-cross-sectional-multicenter-study
#13
Jessica Fernandes Cirelli, Fernanda Garanhani Surita, Maria Laura Costa, Mary Angela Parpinelli, Samira Maerrawi Haddad, José Guilherme Cecatti
OBJECTIVE:  The aim of this study is to evaluate the burden of indirect causes of maternal morbidity/mortality in Brazil. METHODS:  Secondary analysis of a multicenter cross-sectional study conducted in 27 referral obstetric units within the Brazilian Network for Surveillance of Severe Maternal Morbidity. RESULTS:  A total of 82,388 women were surveilled: 9,555 women with severe maternal morbidity were included, and 942 (9.9%) of them had indirect causes of morbidity/mortality...
March 2018: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/29604204/kallikrein-related-peptidases-in-lung-diseases
#14
Woodys Lenga Ma Bonda, Sophie Iochmann, Mélia Magnen, Yves Courty, Pascale Reverdiau
Human tissue kallikreins (KLKs) are 15 members of the serine protease family and are present in various healthy human tissues including airway tissues. Multiple studies have revealed their crucial role in the pathophysiology of a number of chronic, infectious and tumour lung diseases. KLK1, 3 and 14 are involved in asthma pathogenesis, and KLK1 could be also associated with the exacerbation of this inflammatory disease caused by rhinovirus. KLK5 was demonstrated as an influenza virus activating protease in humans, and KLK1 and 12 could also be involved in the activation and spread of these viruses...
March 1, 2018: Biological Chemistry
https://www.readbyqxmd.com/read/29558968/baldr-a-computational-pipeline-for-paired-heavy-and-light-chain-immunoglobulin-reconstruction-in-single-cell-rna-seq-data
#15
Amit A Upadhyay, Robert C Kauffman, Amber N Wolabaugh, Alice Cho, Nirav B Patel, Samantha M Reiss, Colin Havenar-Daughton, Reem A Dawoud, Gregory K Tharp, Iñaki Sanz, Bali Pulendran, Shane Crotty, F Eun-Hyung Lee, Jens Wrammert, Steven E Bosinger
B cells play a critical role in the immune response by producing antibodies, which display remarkable diversity. Here we describe a bioinformatic pipeline, BALDR (BCR Assignment of Lineage using De novo Reconstruction) that accurately reconstructs the paired heavy and light chain immunoglobulin gene sequences from Illumina single-cell RNA-seq data. BALDR was accurate for clonotype identification in human and rhesus macaque influenza vaccine and simian immunodeficiency virus vaccine induced vaccine-induced plasmablasts and naïve and antigen-specific memory B cells...
March 20, 2018: Genome Medicine
https://www.readbyqxmd.com/read/29522425/san-wu-huangqin-decoction-a-chinese-herbal-formula-inhibits-influenza-a-pr-8-34-h1n1-virus-infection-in-vitro-and-in-vivo
#16
Qinhai Ma, Qingtian Yu, Xuefeng Xing, Sinian Liu, Chunyu Shi, Jiabo Luo
The San Wu Huangqin Decoction (SWHD), a traditional Chinese medicine formula, is used to treat colds caused by exposure to wind-pathogen, hyperpyrexia, infectious diseases and cancer; moreover, it is used for detoxification. The individual herbs of SWHD, such as Sophora flavescens and Scutellaria baicalensis , exhibit a wide spectrum of antiviral, anti-inflammatory, antibacterial, anticancer and other properties. The Chinese compound formula of SWHD is composed of S. flavescens, S. baicalensis and Rehmannia glutinosa ...
March 9, 2018: Viruses
https://www.readbyqxmd.com/read/29505169/effects-of-let-7e-on-lps-stimulated-thp-1-cells-assessed-by-itraq-proteomic-analysis
#17
Lian Gui, Qianqian Zhang, Yan Cai, Xiaohong Deng, Yingke Zhang, Cheukfai Li, Qi Guo, Xiaoshun He, Junqi Huang
PURPOSE: Previous studies have demonstrated that let-7e is associated with inflammatory responses. To date, the roles and mechanisms of let-7e have not been completely revealed.Therefore, we aim to identify proteins associated with let-7e overexpression and explore their functions in the immune responses, including in cytokine production. EXPERIMENTAL DESIGN: High-throughput isobaric tag for relative and absolute quantitation (iTRAQ) technology is used to provide the first genome-wide study of THP-1 cells transfected with let-7e mimic followed by lipopolysaccharide (LPS) stimulation...
March 5, 2018: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/29503114/factors-contributing-to-declination-of-annual-influenza-vaccination-by-healthcare-workers-caring-for-cancer-patients-an-australian-experience
#18
T C Surtees, B W Teh, M A Slavin, L J Worth
Healthcare workers (HCWs) at an Australian cancer centre were evaluated using a voluntary declination form program to determine factors contributing to declination of annual influenza vaccination. Overall, 1835/2041 HCWs (89.9%) completed a consent or declination form; 1783 were vaccinated and 52 declined. Staff roles with minimal patient contact were significantly associated with lower vaccine uptake (adjusted odds ratio 0.48, 95% confidence interval 0.23-0.99). Reasons for vaccine refusal included personal choice (41%), previous side-effect/s (23...
March 27, 2018: Vaccine
https://www.readbyqxmd.com/read/29496540/stable-incorporation-of-gm-csf-into-dissolvable-microneedle-patch-improves-skin-vaccination-against-influenza
#19
Elizabeth Q Littauer, Lisa K Mills, Nicole Brock, E Stein Esser, Andrey Romanyuk, Joanna A Pulit-Penaloza, Elena V Vassilieva, Jacob T Beaver, Olivia Antao, Florian Krammer, Richard W Compans, Mark R Prausnitz, Ioanna Skountzou
The widely used influenza subunit vaccine would benefit from increased protection rates in vulnerable populations. Skin immunization by microneedle (MN) patch can increase vaccine immunogenicity, as well as increase vaccination coverage due to simplified administration. To further increase immunogenicity, we used granulocyte-macrophage colony stimulating factor (GM-CSF), an immunomodulatory cytokine already approved for skin cancer therapy and cancer support treatment. GM-CSF has been shown to be upregulated in skin following MN insertion...
April 28, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29485353/seasonal-influenza-vaccine-in-immunocompromised-persons
#20
Mohammad Bosaeed, Deepali Kumar
Immunocompromised persons are at high risk of complications from influenza infection. This population includes those with solid organ transplants, hematopoietic stem cell transplants, solid cancers and hematologic malignancy as well as those with autoimmune conditions receiving biologic therapies. In this review, we discuss the impact of influenza infection and evidence for vaccine effectiveness and immunogenicity. Overall, lower respiratory disease from influenza is common; however, vaccine immunogenicity is low...
February 27, 2018: Human Vaccines & Immunotherapeutics
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