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https://www.readbyqxmd.com/read/28331840/consensus-statement-on-the-management-of-patients-with-hcv-infection-in-romania
#1
REVIEW
(no author information available yet)
BACKGROUND: HCV direct-acting antivirals (DAAs) have made treatment easier for both patients and healthcare practitioners, but have also brought new challenges in terms of patient management and monitoring prior to, during, and after treatment. METHODS: To sum up and unify the clinical experience of Romanian DAA prescribing physicians, we have organized a Consensus Meeting in November 2016 in Bucharest, Romania. CONSENSUS STATEMENT: The Consensus Meeting has provided expert answers to ten significant questions regarding HCV infection, namely: How do we diagnose patients with HCV infection? How do we stage liver disease in patients with HCV infection? How do we monitor patients with HCV infection prior to treatment? Which patients with HCV infection do we treat? When do we start treatment for HCV infection? What regimens do we use for treating HCV infection? How do we monitor patients with HCV infection during treatment? What adverse events should we expect during treatment of HCV infection and how do we prevent/manage them? How do we monitor patients with HCV infection after treatment? How do we expect the landscape of HCV to change in the following years? ...
March 2017: Germs
https://www.readbyqxmd.com/read/28328183/seroprevalence-of-bartonella-species-coxiella-burnetii-and-toxoplasma-gondii-among-patients-with-hematological-malignancies-a-pilot-study-in-romania
#2
C J Messinger, E S Gurzau, E B Breitschwerdt, C I Tomuleasa, S J Trufan, M M Flonta, R G Maggi, I B Neagoe, P M Rabinowitz
Patients receiving immunosuppressive cancer treatments in settings where there is a high degree of human-animal interaction may be at increased risk for opportunistic zoonotic infections or reactivation of latent infections. We sought to determine the seroprevalence of selected zoonotic pathogens among patients diagnosed with haematologic malignancies and undergoing chemotherapeutic treatments in Romania, where much of the general population lives and/or works in contact with livestock. A convenience sample of 51 patients with haematologic cancer undergoing chemotherapy at a referral clinic in Cluj-Napoca, Romania, was surveyed regarding animal exposures...
March 22, 2017: Zoonoses and Public Health
https://www.readbyqxmd.com/read/28326074/diversity-and-biomineralization-potential-of-the-epilithic-bacterial-communities-inhabiting-the-oldest-public-stone-monument-of-cluj-napoca-transylvania-romania
#3
Adrian-Ştefan Andrei, Manuela R Păuşan, Tudor Tămaş, Nicolae Har, Lucian Barbu-Tudoran, Nicolae Leopold, Horia L Banciu
In this study, we investigated the biomineralization potential and diversity of the epilithic bacterial communities dwelling on the limestone statue of Saint Donatus, the oldest public monument of Cluj-Napoca city (Transylvania region, NW Romania). Their spatial distribution together with phylogenetic and metabolic diversity, as well as their capacity to precipitate calcium carbonate was evaluated by combining molecular and phenotypic fingerprinting methods with X-ray diffraction, Fourier transform infrared spectroscopy, and scanning electron-microscopy analyses...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28322689/neurologic-complications-of-influenza-b-virus-infection-in-adults-romania
#4
Corneliu P Popescu, Simin A Florescu, Emilia Lupulescu, Mihaela Zaharia, Gratiela Tardei, Mihaela Lazar, Emanoil Ceausu, Simona M Ruta
We characterized influenza B virus-related neurologic manifestations in an unusually high number of hospitalized adults at a tertiary care facility in Romania during the 2014-15 influenza epidemic season. Of 32 patients with a confirmed laboratory diagnosis of influenza B virus infection, neurologic complications developed in 7 adults (median age 31 years). These complications were clinically diagnosed as confirmed encephalitis (4 patients), possible encephalitis (2 patients), and cerebellar ataxia (1 patient)...
April 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28319262/ethnic-familial-and-religious-identity-of-roma-adolescents-in-bulgaria-czech-republic-kosovo-and-romania-in-relation-to-their-level-of-well-being
#5
Radosveta Dimitrova, Fons J R van de Vijver, Jitka Taušová, Athanasios Chasiotis, Michael Bender, Carmen Buzea, Fitim Uka, Ergyul Tair
This study examines ethnic, national, familial, and religious identity and well-being of 632 Roma minority and 589 majority adolescents (age: M = 15.98 years, SD = 1.34) in Bulgaria, the Czech Republic, Kosovo, and Romania. Results indicated that Roma showed lower endorsement of national identity but stronger religious identity than their majority counterparts. Path models showed positive associations of familial and religious identities with well-being, whereas Roma identity was negatively associated with well-being, particularly for Roma in Bulgaria and Kosovo (countries with a less active policy toward improving conditions of Roma)...
March 20, 2017: Child Development
https://www.readbyqxmd.com/read/28316505/from-nappe-stacking-to-exhumation-cretaceous-tectonics-in-the-apuseni-mountains-romania
#6
Martin Kaspar Reiser, Ralf Schuster, Richard Spikings, Peter Tropper, Bernhard Fügenschuh
New Ar-Ar muscovite and Rb-Sr biotite age data in combination with structural analyses from the Apuseni Mountains provide new constraints on the timing and kinematics of deformation during the Cretaceous. Time-temperature paths from the structurally highest basement nappe of the Apuseni Mountains in combination with sedimentary data indicate exhumation and a position close to the surface after the Late Jurassic emplacement of the South Apuseni Ophiolites. Early Cretaceous Ar-Ar muscovite ages from structurally lower parts in the Biharia Nappe System (Dacia Mega-Unit) show cooling from medium-grade conditions...
2017: International Journal of Earth Sciences: Geologische Rundschau
https://www.readbyqxmd.com/read/28295859/adverse-effects-of-isotretinoin-a-large-retrospective-review
#7
Piotr Brzezinski, Katarzyna Borowska, Anca Chiriac, Janusz Smigielski
Acne is a very common and disfiguring disease that affects mostly adolescents and, to some extent, adults. The objective of our study was to estimate the adverse effects after isotretinoin by treatment of 3,525 patients due to acne vulgaris in a 5-year observation. Retrospective, comparative study was carried out in Poland and Romania from January 2012 to August 2016. Inclusion criteria into this study were moderate, severe, and nodulocystic inflammatory acne vulgaris. Exclusion criteria were mild acne, pregnant, and lactating women...
March 14, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/28295203/pla2g6-mutations-associated-with-a-continuous-clinical-spectrum-from-neuroaxonal-dystrophy-to-hereditary-spastic-paraplegia
#8
Burcak Ozes, Nazan Karagoz, Rebecca Schüle, Adriana Rebelo, María-Jesús Sobrido, Florian Harmuth, Matthis Synofzik, Samuel Ignacio Pascual Pascual, Melek Colak, Beyza Ciftci-Kavaklioglu, Batuhan Kara, Andrés Ordóñez-Ugalde, Beatriz Quintáns, Michael A Gonzalez, Aysun Soysal, Stephan Zuchner, Esra Battaloglu
PLA2G6-associated neurodegeneration (PLAN) and hereditary spastic paraplegia (HSP) are two groups of heterogeneous neurodegenerative diseases. In this study, we report PLA2G6 gene mutations in three families from Turkey, Morocco, and Romania. Two affected Turkish siblings presenting HSP adds the disease to PLAN phenotypes. They were homozygous for the PLA2G6 missense c.2239C>T, p.Arg747Trp variant and the ages of onset were 9 and 21. Parkinsonism, dystonia or cognitive decline were not the clinical elements in these patients contrary to the cases that has been previously reported with the same variant, however, iron accumulation was evident in their cranial MRI...
March 13, 2017: Clinical Genetics
https://www.readbyqxmd.com/read/28289467/the-development-of-a-consensus-definition-for-healthcare-improvement-science-his-in-seven-european-countries-a-consensus-methods-approach
#9
Brigita Skela-Savič, Rhoda Macrae, Manuel Lillo-Crespo, Kevin D Rooney
INTRODUCTION: There is a limited body of research in the field of healthcare improvement science (HIS). Quality improvement and 'change making' should become an intrinsic part of everyone's job, every day in all parts of the healthcare system. The lack of theoretical grounding may partly explain the minimal transfer of health research into health policy. METHODS: This article seeks to present the development of the definition for healthcare improvement science. A consensus method approach was adopted with a two-stage Delphi process, expert panel and consensus group techniques...
June 1, 2017: Zdravstveno Varstvo
https://www.readbyqxmd.com/read/28274135/the-pain-and-pride-of-angel-mothers-disappointments-and-desires-around-reproductive-loss-in-romania
#10
Erica van der Sijpt
In this article, I highlight how Romanian women make sense of the losses of pregnancies and babies. Based on 15 months of fieldwork in a Transylvanian town, and on interviews with and observations among 'angel mothers' (women who have lost unborn or live-born children) in the Romanian capital Bucharest, I discuss the disappointments and desires that surface when reproduction goes awry. The criticisms of these 'angel mothers' throw into sharp relief wider disappointments with biomedical, political, and religious establishments, and continuing social struggles in postcommunist Romania...
February 16, 2017: Medical Anthropology
https://www.readbyqxmd.com/read/28271314/the-abstracts-of-the-26th-congress-of-esctaic-timisoara-romania-september-22-24-2016
#11
(no author information available yet)
No abstract text is available yet for this article.
March 7, 2017: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/28270499/pd-l1-is-a-therapeutic-target-of-the-bromodomain-inhibitor-jq1-and-combined-with-hla-class-i-a-promising-prognostic-biomarker-in-neuroblastoma
#12
Ombretta Melaiu, Marco Mina, Marco Chierici, Renata Boldrini, Giuseppe Jurman, Paolo Romania, Valerio D'Alicandro, Maria Chiara Benedetti, Aurora Castellano, Tao Liu, Cesare Furlanello, Franco Locatelli, Doriana Fruci
PURPOSE: This study sought to evaluate expression of PD-L1 and HLA class I on neuroblastoma cells and PD-1 and LAG3 on tumor-infiltrating lymphocytes to better define patient risk-stratification and understand whether this tumor may benefit from therapies targeting immune-checkpoint molecules. EXPERIMENTAL DESIGN: In situ immunohistochemical staining for PD-L1, HLA class I, PD-1 and LAG3 was assessed in 77 neuroblastoma specimens, previously characterized for tumor-infiltrating T cell-density, and correlated with clinical outcome...
March 7, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28270115/genetic-affinities-among-the-historical-provinces-of-romania-and-central-europe-as-revealed-by-an-mtdna-analysis
#13
Relu Cocoş, Sorina Schipor, Montserrat Hervella, Petru Cianga, Roxana Popescu, Claudia Bănescu, Mihai Constantinescu, Alina Martinescu, Florina Raicu
BACKGROUND: As a major crossroads between Asia and Europe, Romania has experienced continuous migration and invasion episodes. The precise routes may have been shaped by the topology of the territory and had diverse impacts on the genetic structure of mitochondrial DNA (mtDNA) in historical Romanian provinces. We studied 714 Romanians from all historical provinces, Wallachia, Dobrudja, Moldavia, and Transylvania, by analyzing the mtDNA control region and coding markers to encompass the complete landscape of mtDNA haplogroups...
March 7, 2017: BMC Genetics
https://www.readbyqxmd.com/read/28261565/borrelia-diversity-and-co-infection-with-other-tick-borne-pathogens-in-ticks
#14
Cristian Raileanu, Sara Moutailler, Ionuţ Pavel, Daniela Porea, Andrei D Mihalca, Gheorghe Savuta, Muriel Vayssier-Taussat
Identifying Borrelia burgdorferi as the causative agent of Lyme disease in 1981 was a watershed moment in understanding the major impact that tick-borne zoonoses can have on public health worldwide, particularly in Europe and the USA. The medical importance of tick-borne diseases has long since been acknowledged, yet little is known regarding the occurrence of emerging tick-borne pathogens such as Borrelia spp., Anaplasma phagocytophilum, Rickettsia spp., Bartonella spp., "Candidatus Neoehrlichia mikurensis", and tick-borne encephalitis virus in questing ticks in Romania, a gateway into Europe...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28259468/mathematical-modeling-of-sulfur-dioxide-concentration-in-the-western-part-of-romania
#15
Alina Barbulescu, Lucica Barbes
Nowadays air pollution is a major issue, due to its effect on the human health and environment. Therefore, in this article, we analyze the evolution of sulfur dioxide (SO2) concentration for eight months (November 2015-June 2016) at three monitoring stations in Timisoara, Romania. The results indicate that the legal limits have been exceeded only a few times and the pollutants' distribution is strongly influenced by the relative atmospheric calm in the County. We also propose a new model for the SO2 dissipation, which takes into account the individual data series, as well as the specific atmospheric conditions...
March 1, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28255379/medical-legislation-educational-needs-assessment-for-dental-students
#16
S M Piţuru, A Nanu, A Bucur
Rationale (hypothesis): Many studies have highlighted the vulnerabilities in medical practice due to the legislation ignorance. Therefore, developing special programs for students training is needed and has become imperative. Objective: This research aimed to identify the educational needs for the 5th year students in "Carol Davila" School of Dentistry in Bucharest, related to the legislation in dentistry and its area of application. Methods and results: 199 students were invited to respond to a specially designed questionnaire...
January 2017: Journal of Medicine and Life
https://www.readbyqxmd.com/read/28255195/the-long-range-transport-of-pinaceae-pollen-an-example-in-krak%C3%A3-w-southern-poland
#17
Kazimierz Szczepanek, Dorota Myszkowska, Elżbieta Worobiec, Katarzyna Piotrowicz, Monika Ziemianin, Zuzanna Bielec-Bąkowska
High Pinaceae pollen concentrations in the air and on the surface of puddles before the main pollen season started were observed in Kraków (southern Poland) in May 2013. The paper presents the results of detailed studies of the composition and source of the "yellow rain" in 2013, and as a comparison, the Pinaceae pollen concentrations and samples collected from the ground surface in 2014 were considered. The air samples were collected using the volumetric method (Hirst-type device), while pollen grains sampled from the ground surface were processed using a modified Erdtman acetolysis method...
2017: Aerobiologia
https://www.readbyqxmd.com/read/28251019/the-role-of-follow-up-in-monitoring-the-outcomes-of-prematurity-in-a-cohort-of-romanian-infants
#18
Anca Bivoleanu, Andreea Avasiloaiei, Mihaela Moscalu, Maria Stamatin
BACKGROUND: The rate of preterm births in Romania is one of the highest among European countries. However, there is little information regarding the ways in which premature birth affects the outcome in Romanian preterm infants. AIMS: To investigate the effects of early developmental intervention after discharge from the hospital on motor and cognitive development in preterm infants. STUDY DESIGN: Longitudinal observational study. METHODS: We performed the Amiel-Tison neurologic evaluation at discharge and the Bayley Scales of Infant Development from 3 to 24 months...
January 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28249759/modeling-the-carbon-monoxide-dissipation-in-timisoara-romania
#19
Alina Barbulescu, Lucica Barbes
Modeling the evolution of pollutants' concentration is important for predicting their impact on the human health and implementing measures for a sustainable development and environmental protection. Since the carbon dioxide (CO) is one of the main pollutants that affect the urban environment, the present study aimed at building a model for the evolution of the mean daily and monthly concentration in Timisoara, Romania. We found a non-linear direct dependence of CO concentration on the temperature and humidity and an inverse proportional relationship with the wind speed...
February 26, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28246499/energy-systems-efficiency-influences-the-results-of-2-000-m-race-simulation-among-elite-rowers
#20
Stefan Adrian Martin, Valeriu Tomescu
HYPOTHESIS: Energy efficiency within an elite group of athletes will ensure metabolic adaptation during training. OBJECTIVES: To identify energy system efficiency and contribution according to exercise intensity, and performance obtained during a 2,000 m race simulation in an elite group of rowers. METHOD: An observational cross-sectional study was conducted in February 2016 in Bucharest, Romania, on a group of 16 elite rowers. Measurements were performed through Cosmed Quark CPET equipment, and Concept 2 ergometer, by conducting a VO2max test over a standard rowing distance of 2,000 m...
2017: Clujul Medical (1957)
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