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Charlson's comorbidity-age index

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https://www.readbyqxmd.com/read/29474865/trajectories-of-plasma-igf-1-igfbp-3-and-their-ratio-in-the-mayo-clinic-study-of-aging
#1
Alexandra M V Wennberg, Clinton E Hagen, Ronald C Petersen, Michelle M Mielke
Insulin-like growth factor 1 (IGF-1) has been associated with osteoporosis, cardiovascular disease, cancer, neurodegenerative diseases, and mortality in middle and older aged adults. Cross-sectionally, IGF-1 decreases with age and levels of IGF-1 are markedly different between individuals. However, little is known about intra-individual trajectories of IGF-1. We examined baseline and serial measures of plasma total IGF-1, IGF binding protein (IGFBP)-3, and their ratio, which is a proxy for bioavailable IGF-1, among 1618 adults, aged 50-95, enrolled in the Mayo Clinic Study of Aging...
February 20, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29473127/difference-in-the-degree-of-improvement-in-patient-reported-outcomes-after-total-knee-arthroplasty-between-octogenarians-and-sexagenarians-a-propensity-score-matching-analysis
#2
Seok Tae Yun, Byung Kag Kim, Byung Moon Ahn, Kwang Jun Oh
BACKGROUND: As the population ages, the use of primary total knee arthroplasty (TKA) is on the rise in the octogenarian population. AIMS: The objective of this study was to compare patient-reported outcomes after TKA in octogenarians versus sexagenarians. METHODS: This retrospective case-controlled comparative study with a propensity score matching analysis was conducted by 251 patients who underwent TKA for degenerative osteoarthritis of the knee...
February 22, 2018: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29466956/outcome-and-prognostic-factors-of-patients-with-right-sided-infective-endocarditis-requiring-intensive-care-unit-admission
#3
Hugues Georges, Olivier Leroy, Norair Airapetian, Nicolas Lamblin, Elie Zogheib, Patrick Devos, Sebastien Preau
BACKGROUND: Right-sided infective endocarditis (RSIE) is an uncommon diagnosis accounting for less than 10% of cases of infective endocarditis. Optimal management for severely ill patients with RSIE remains challenging because few studies reported on management and outcome. The goal of our study was to determine outcome and associated prognostic factors in a population of ICU patients with a diagnosis of definite, active and severe RSIE. METHODS: We performed a retrospective study in 10 French ICUs between January 2002 and December 2012...
February 21, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29463219/perceived-acceptability-and-preferences-for-low-intensity-early-activity-interventions-of-older-hospitalized-medical-patients-exposed-to-bed-rest-a-cross-sectional-study
#4
Mary T Fox, Souraya Sidani, Dina Brooks, Hugh McCague
BACKGROUND: Hospitalized older patients spend most of their time in bed, putting them at risk of experiencing orthostatic intolerance. Returning persons to their usual upright activity level is the most effective way to prevent orthostatic intolerance but some older patients have limited activity tolerance, supporting the need for low-intensity activity interventions. Consistent with current emphasis on patient engagement in intervention design and evaluation, this study explored older hospitalized patients' perceived acceptability of, and preference for, two low-intensity early activity interventions (bed-to-sitting and sitting-to-walking), and characteristics (gender, illness severity, comorbidity, illnesses and medications with orthostatic effects, and baseline functional capacity) associated with perceived acceptability and preference...
February 20, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29463019/health-differences-between-roma-and-non-roma-in-the-slovak-dialyzed-population
#5
Gabriel Kolvek, Zuzana Straussova, Maria Majernikova, Jaroslav Rosenberger, Jitse P van Dijk
Roma health has not been studied systematically. Thus far, it has been shown that Roma compared to non-Roma have a significantly higher likelihood of getting end-stage renal disease and that their chances for survival on dialysis are lower. Evidence is lacking regarding morbidity between Roma and non-Roma. The aim was to compare the health status of dialyzed Roma and non-Roma using the Charlson comorbidity index (CCI). All Slovak dialysis centers for adults were asked to fill in a questionaire with demographic and clinical data, including comorbidity...
February 18, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29462121/patient-mortality-in-geriatric-distal-femur-fractures
#6
Philip Myers, Patrick Laboe, Kory J Johnson, Peter D Fredericks, Renn J Crichlow, Dean C Maar, Timothy G Weber
OBJECTIVES: To estimate 1-year mortality rates in elderly patients who undergo operative treatment for distal femur fractures and identify potential risk factors for mortality. DESIGN: Retrospective chart review. SETTING: Level 1 and Level 2 trauma centers. PATIENTS/PARTICIPANTS: Two hundred eighty-three elderly patients (average age 76.0 years ± 9.8) who sustained distal femur fractures between 2002 and 2012. INTERVENTION: Fracture fixation of the distal femur...
March 2018: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29459015/endovascular-interventions-decrease-length-of-hospitalization-and-are-cost-effective-in-acute-mesenteric-ischemia
#7
Young Erben, Clinton D Protack, Raymond A Jean, Brandon J Sumpio, Samuel M Miller, Shirley Liu, Gerardo Trejo, Bauer E Sumpio
OBJECTIVE: Acute mesenteric ischemia (AMI) continues to be one of the most devastating diagnoses requiring emergent vascular intervention. There is a national trend toward increased use of endovascular procedures, with improved survival for the treatment of these patients. Our aim was to evaluate whether this trend has changed the treatment of AMI and the subsequent impact on length of hospitalization and hospitalization costs. METHODS: We identified all patients admitted for AMI from the National Inpatient Sample from 2004 to 2014 who received open surgical revascularization (OPEN) or an endovascular intervention (ENDO)...
February 16, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29456209/assessment-of-prevalence-and-clinical-outcome-of-frailty-in-an-elderly-predialysis-cohort-using-simple-tools
#8
Hatem Ali, Tarek Abdelaziz, Fatima Abdelaal, Jyoti Baharani
The relationship between frailty and chronic kidney disease in elderly population has been recognized; however, studies concentrating on frailty in predialysis patients are limited. For nephrologists, the recognition of frailty is important as it has impact on decisions on the choice of dialysis modality and sometimes on whether dialysis is indeed in the patients' best interests. Many of the tools for routine assessment of frailty are not easily applicable to those clinicians not practicing elderly care medicine...
January 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29454848/a-multi-center-derivation-and-validation-of-a-simple-predictive-index-for-healthcare-associated-clostridium-difficile-infection
#9
Meghann L Davis, Harlan G Sparrow, Judy O Ikwuagwu, William L Musick, Kevin W Garey, Katherine K Perez
OBJECTIVES: Clostridium difficile infection (CDI) is the most common cause of healthcare-associated infections in the United States. Despite well-established risk factors, very little research has focused on use of these variables to identify a patient population at high-risk for CDI to target with primary prevention strategies. A predictive index for healthcare-associated CDI could improve clinical care and guide research for primary prevention trials. Our objective was to develop a predictive index to identify patients at high-risk for healthcare-associated CDI...
February 15, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29449147/relation-between-hba-1c-and-incident-cardiovascular-disease-over-a-period-of-6-years-in-the-hong-kong-population
#10
E Y F Wan, E Y T Yu, C S C Fung, W Y Chin, D Y T Fong, A K C Chan, C L K Lam
AIM: The current trend on diabetes management advocates replacing the paradigm from a uniform to an individualized patient-centered haemoglobin A 1c (HbA 1c ) target, but there is no consensus on the optimal HbA 1c level. The study aimed at examining the association between HbA 1c and the risk of cardiovascular diseases (CVD) for diabetic patients with different characteristics, in order to identify patient-centered treatment targets. METHODS: A retrospective cohort study was conducted on 115,782 Chinese adult primary care patients with type 2 diabetes mellitus (DM) but no known CVD history, who were prescribed antidiabetic medications in 2010-2011...
February 3, 2018: Diabetes & Metabolism
https://www.readbyqxmd.com/read/29441963/do-patients-with-diabetes-type-2-or-chronic-heart-failure-understand-a-medication-plan
#11
L Botermann, A Wachter, K Monzel, K Krueger, S Ewen, F Mahfoud, N Griese-Mammen, M Schulz, U Laufs
A standardized medication plan (MP) was recently enacted into German law (§ 31a SGB V). The purpose of our study was to assess if patients with chronic diseases requiring polymedication understand the standardized MP and can transfer the given information into practice. 100 patients who took at least five medicines regularly were prospectively included in a cross-sectional study: 50 patients with the primary diagnosis chronic heart failure (CHF), and 50 with diabetes mellitus type 2 (DMT2). We performed a structured test-scenario studying the handling of a provided MP then evaluated the execution of the information on the MP by filling pill boxes and requested patients' opinion...
December 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29441753/diabetes-frequency-of-exercise-and-mortality-over-12-years-analysis-of-the-national-health-insurance-service-health-screening-nhis-heals-database
#12
Woo Young Shin, Taehee Lee, Da Hye Jeon, Hyeon Chang Kim
BACKGROUND: The goal of this study was to analyze the relationship between exercise frequency and all-cause mortality for individuals diagnosed with and without diabetes mellitus (DM). METHODS: We analyzed data for 505,677 participants (53.9% men) in the National Health Insurance Service-National Health Screening (NHIS-HEALS) cohort. The study endpoint variable was all-cause mortality. RESULTS: Frequency of exercise and covariates including age, sex, smoking status, household income, blood pressure, fasting glucose, body mass index, total cholesterol, and Charlson comorbidity index were determined at baseline...
February 19, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29438790/cervical-spinal-fusion-16-year-trends-in-epidemiology-indications-and-in-hospital-outcomes-by-surgical-approach
#13
Stephan N Salzmann, Peter B Derman, Lukas P Lampe, Janina Kueper, Ting Jung Pan, Jingyan Yang, Jennifer Shue, Federico P Girardi, Stephen Lyman, Alexander P Hughes
BACKGROUND: The rate of cervical spinal fusion has been increasing significantly. However, there is paucity of literature describing trends based on surgical approach using complete population databases. We investigated the approach-based trends in epidemiology, indications and in-hospital outcomes of cervical spinal fusion. METHODS: New York's Statewide Planning and Research Cooperative System database was queried to identify patients who underwent primary subaxial cervical fusion from 1997-2012...
February 10, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29433528/effect-of-socioeconomic-inequalities-on-cholecystectomy-outcomes-a-10-year-population-based-analysis
#14
Ping Lu, Nan-Ping Yang, Nien-Tzu Chang, K Robert Lai, Kai-Biao Lin, Chien-Lung Chan
BACKGROUND: Although numerous epidemiological studies on cholecystectomy have been conducted worldwide, only a few have considered the effect of socioeconomic inequalities on cholecystectomy outcomes. Specifically, few studies have focused on the low-income population (LIP). METHODS: A nationwide prospective study based on the Taiwan National Health Insurance dataset was conducted during 2003-2012. The International Classification of ICD-9-CM procedure codes 51...
February 13, 2018: International Journal for Equity in Health
https://www.readbyqxmd.com/read/29432727/acute-pancreatitis-and-pancreatic-cancer-risk-a-nationwide-matched-cohort-study-in-denmark
#15
Jakob Kirkegård, Deirdre Cronin-Fenton, Uffe Heide-Jørgensen, Frank Viborg Mortensen
BACKGROUND & AIMS: Acute pancreatitis may be a risk factor for pancreatic cancer. However, findings from studies on this association are conflicting. We investigated the association between acute pancreatitis and increased risk of pancreatic cancer. METHODS: We conducted a nationwide, population-based, matched cohort study of all patients admitted to a hospital in Denmark with a diagnosis of acute pancreatitis from January 1, 1980 through October 31, 2012. As many as 5 individuals from the general population without acute pancreatitis were matched for age and sex to each patient with acute pancreatitis...
February 9, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29428474/low-skeletal-muscle-mass-outperforms-the-charlson-comorbidity-index-in-risk-prediction-in-patients-undergoing-pancreatic-resections
#16
D Wagner, K Marsoner, A Tomberger, J Haybaeck, J Haas, G Werkgartner, H Cerwenka, H Bacher, H J Mischinger, P Kornprat
INTRODUCTION: Low skeletal muscle mass is a known predictor of morbidity and mortality in patients undergoing major pancreatic surgeries. We sought to combine low skeletal muscle mass with established risk predictors to improve their prognostic capacity for postoperative outcome and morbidity. METHODS: As established parameters to predict preoperative mortality risk for patients, the ASA classification and the Charlson Comorbidity Index (CCI) were used. The Hounsfield Units Average Calculation (HUAC) was measured to define low skeletal muscle mass in 424 patients undergoing pancreatic resections for malignancies...
February 7, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29427505/does-the-association-of-comorbidity-with-1-year-mortality-after-hip-fracture-differ-according-to-gender-the-norwegian-epidemiologic-osteoporosis-studies-norepos
#17
Brit Solvor L Riska, Lisa Forsén, Tone K Omsland, Anne Johanne Søgaard, Haakon E Meyer, Kristin Holvik
BACKGROUND/OBJECTIVES: Excess mortality after hip fracture is higher in men than in women. The objective was to study whether comorbidity differs in men and women with hip fracture and to what degree differences in comorbidity according to gender may explain the higher excess mortality in men. DESIGN: Population-based matched cohort covering the population aged 50 and older in Norway. SETTING: Specialist healthcare (individuals with hip fracture) and general population (controls)...
February 10, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29424185/predictors-of-early-failure-and-secondary-patency-in-native-arteriovenous-fistulas-for-hemodialysis
#18
Rui Abreu, Sara Rioja, Joaquin Vallespin, Xavier Vinuesa, Ruben Iglesias, Jose Ibeas
BACKGROUND: Native arteriovenous fistula (AVF) is considered the gold standard of vascular access for hemodialysis due to its longer survival, fewer complications, lower mortality and costs. Patency is important for effective dialysis treatment and this remains a challenge in nephrology. There are no well-defined prognostic factors for early and long-term AVF survival. The aim of this study was to evaluate comorbidity, analytical and ultrasound (US) variables as prognostic factors for early failure and AVF patency...
February 8, 2018: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/29421224/methicillin-resistant-staphylococcus-aureus-mrsa-bacteremia-correlations-between-clinical-phenotypic-genotypic-characteristics-and-mortality-in-a-tertiary-teaching-hospital-in-malaysia
#19
Pik San Sit, Cindy Shuan Ju Teh, Nuryana Idris, Sasheela Ponnampalavanar
Methicillin-resistant Staphylococcus aureus (MRSA) bacteremia is a serious infection that can result in significant morbidity and mortality. A retrospective cohort study was conducted to determine the predictors of mortality in patient with MRSA bacteremia correlating with clinical, phenotypic and genotypic characteristics of the relevant strains. Most of the bacteremia cases were healthcare-associated (P < 0.0001). Older age (P < 0.0001) and comorbidities (diabetes mellitus, hypertension and chronic kidney disease) were identified as the risk factors for MRSA bacteremia...
February 6, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29420599/comorbidity-disability-and-healthcare-expenditure-of-ankylosing-spondylitis-in-korea-a-population-based-study
#20
Jeong Seok Lee, Baek-Lok Oh, Hee Young Lee, Yeong Wook Song, Eun Young Lee
BACKGROUND: Ankylosing spondylitis (AS) is an inflammatory rheumatic disease typically diagnosed in young age and follows a chronic progressive course. Its impact on the patient is life-long and the burden that AS exerts on society is increasing cumulatively every year. We aimed to quantify the burden of AS and to identify the factors associated with comorbidity, disability, and healthcare expenditure in Korean AS patients. METHODS: We conducted a nationwide, population-based study using health insurance data (2003-2013)...
2018: PloS One
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