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Charlson's comorbidity-age index

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https://www.readbyqxmd.com/read/28719660/factors-associated-with-life-sustaining-treatment-restriction-in-a-general-intensive-care-unit
#1
Stein Arve Skjaker, Henrik Hoel, Vegard Dahl, Knut Stavem
PURPOSE: Few previous studies have investigated associations between clinical variables available after 24 hours in the intensive care unit (ICU), including the Charlson Comorbidity Index (CCI), and decisions to restrict life-sustaining treatment. The aim of this study was to identify factors associated with the life-sustaining treatment restriction and to explore if CCI contributes to explaining decisions to restrict life-sustaining treatment in the ICU at a university hospital in Norway from 2007 to 2009...
2017: PloS One
https://www.readbyqxmd.com/read/28719079/associations-between-drugs-and-small-bowel-mucosal-bleeding-a-multicenter-capsule-endoscopy-study
#2
Ryota Niikura, Atsuo Yamada, Koutarou Maki, Masanao Nakamura, Hirotsugu Watabe, Mitsuhiro Fujishiro, Shiro Oka, Motohiro Esaki, Shunji Fujimori, Atsushi Nakajima, Naoki Ohmiya, Takayuki Matsumoto, Shinji Tanaka, Kazuhiko Koike, Choitsu Sakamoto
OBJECTIVES: Although several drugs may induce small-bowel mucosal injuries, it is unclear whether these injuries contribute to overt small-bowel bleeding. This study was designed to evaluate the associations between drug use and small-bowel mucosal injury and between these mucosal injuries and overt bleeding in a disease-relevant population. METHODS: We retrospectively studied patients with suspected small-bowel diseases who underwent capsule endoscopy between 2010 and 2013...
July 18, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28716070/comorbidity-and-metabolic-syndrome-in-patients-with-multiple-sclerosis-from-asturias-and-catalonia-spain
#3
Antoni Sicras-Mainar, Elena Ruíz-Beato, Ruth Navarro-Artieda, Jorge Maurino
BACKGROUND: The impact of comorbidity on multiple sclerosis (MS) is a new area of interest. Limited data on the risk factors of metabolic syndrome (MetS) is currently available. The aim of this study was to estimate the presence of comorbid conditions and MetS in a sample of adult patients with MS. METHODS: A retrospective, cohort study was conducted using electronic medical records from 19 primary care centres in Catalonia and Asturias, Spain. The number of chronic diseases (diagnoses), the Charlson Comorbidity Index and the individual Case-mix Index were used to assess general comorbidity variables...
July 17, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28712548/excess-mortality-between-2007-and-2014-among-patients-with-clostridium-difficile-infection-a-french-health-insurance-database-analysis
#4
F Barbut, S Bouée, L Longepierre, M Goldberg, C Bensoussan, L Levy-Bachelot
BACKGROUND: The impact of CDI (Clostridium difficile infections) on mortality is controversial. AIM: To assess excess mortality due to CDI in France. METHOD: Two cohorts of patients with CDI and a cohort of matched controls were extracted from a 1% representative sample of subjects covered by the general health insurance system in France (EGB database, 660,000 patients). The CDI patients were hospitalized with CDI as a principal diagnosis (PD) or an associated diagnosis (AD) between 2007 and 2014, but not in 2006...
July 13, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28711537/increased-risk-of-anxiety-or-depression-after-traumatic-spinal-cord-injury-in-patients-with-pre-existing-hyperlipidemia-a-population-based-study
#5
Sher-Wei Lim, Tee-Tau Eric Nyam, Chung-Han Ho, Yow-Ling Shiue, Jhi-Joung Wang, Chung-Ching Chio, Jinn-Rung Kuo
OBJECTIVE: Anxiety or depression (AD) is a common complication after traumatic spinal cord injury (tSCI). This study sought to investigate the role of pre-existing hyperlipidemia in new-onset AD after tSCI using a longitudinal population database. METHODS: This retrospective cohort study used Longitudinal Health Insurance Database data from January 1997 to December 2011. The case and comparison groups were individuals who experienced tSCI and who did and did not have pre-existing hyperlipidemia, respectively...
July 12, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28709115/development-and-validation-of-the-korea-dementia-comorbidity-index-kdci-a-nationwide-population-based-cohort-study-from-2002-to-2013
#6
Jae-Hyun Kim, Ki-Bong Yoo, Yunhwan Lee
This study develop and validate a simple and accessible measure of comorbidity, named the Korean Dementia Comorbidity index (KDCI), to assist in predicting the onset of dementia. This study used the National Health Insurance Service-Cohort Sample Database from 2002 to 2013 (n=23,856). Cox proportional hazard model was used to estimate incident dementia (International Classification of Disease, 10th edition (ICD-10) codes: F00-F03, G30, G311), with a hazard ratio higher than 1.05 for each comorbid condition being assigned a score...
June 7, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28707992/transitional-care-services-a-quality-and-safety-process-improvement-program-in-neurosurgery
#7
Faith C Robertson, Jessica L Logsdon, Hormuzdiyar H Dasenbrock, Sandra C Yan, Siobhan M Raftery, Timothy R Smith, William B Gormley
OBJECTIVE Readmissions increasingly serve as a metric of hospital performance, inviting quality improvement initiatives in both medicine and surgery. However, few readmission reduction programs have targeted surgical patient populations. The objective of this study was to establish a transitional care program (TCP) with the goal of decreasing length of stay (LOS), improving discharge efficiency, and reducing readmissions of neurosurgical patients by optimizing patient education and postdischarge surveillance...
July 14, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28702893/medical-costs-of-treating-breast-cancer-among-younger-medicaid-beneficiaries-by-stage-at-diagnosis
#8
Justin G Trogdon, Donatus U Ekwueme, Diana Poehler, Cheryll C Thomas, Katherine Reeder-Hayes, Benjamin T Allaire
BACKGROUND: Younger women (aged 18-44 years) diagnosed with breast cancer often face more aggressive tumors, higher treatment intensity, and lower survival rates than older women. In this study, we estimated incident breast cancer costs by stage at diagnosis and by race for younger women enrolled in Medicaid. METHODS: We analyzed cancer registry data linked to Medicaid claims in North Carolina from 2003 to 2008. We used Surveillance, Epidemiology, and End Results (SEER) Summary 2000 definitions for cancer stage...
July 12, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28701858/early-experience-in-starting-a-laparoscopic-liver-resection-program-in-greece
#9
Georgios C Sotiropoulos, Nikolaos Machairas, Ioannis D Kostakis, Paraskevas Stamopoulos, Petros Charalampoudis, Stylianos Kykalos, Gregory Kouraklis, Dimitrios Mantas
BACKGROUND AND OBJECTIVES: Laparoscopic liver resections (LLRs) have gained wider acceptance during the decade as safe and efficient procedures in the management of several benign and malignant diseases when performed by experienced surgeons. We report our initial institutional experience with LLRs performed by 1 certified hepatobiliary surgeon. METHODS: Patients undergoing LLRs by 1 senior hepatobiliary surgeon in our Institution during the period from January 2012 through January 2017 were prospectively sampled and retrospectively analyzed for the purposes of this study...
January 2017: JSLS: Journal of the Society of Laparoendoscopic Surgeons
https://www.readbyqxmd.com/read/28699940/association-of-stress-biomarkers-with-30-day-unplanned-readmission-and-death
#10
Carole Aubert, Antoine Folly, Mancinetti Marco, Daniel Hayoz, Jacques Donze
BACKGROUND: The theory that posthospitalization stress might increase the risk of postdischarge complications has never been investigated. OBJECTIVE: To assess whether serum levels of stress biomarkers at discharge are associated with readmission and death after an acute-care hospitalization. DESIGN: We prospectively included 346 patients aged ≥50 years admitted to the department of general internal medicine at a large community hospital between April 8, 2013 and September 23, 2013...
July 2017: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/28697111/ninety-day-mortality-as-a-reporting-parameter-for-high-grade-serous-ovarian-cancer-cytoreduction-surgery
#11
Ryan J Spencer, Kari E Hacker, Jennifer J Griggs, Laurel W Rice, R Kevin Reynolds, Shitanshu Uppal
OBJECTIVE: To evaluate the utility of using 90-day as an adjunct to 30-day mortality rates after surgical cytoreduction for serous ovarian cancer and to compare them across hospitals of differing case volumes over time. METHODS: We performed a retrospective cohort study using the National Cancer Database of women undergoing cytoreductive surgery for high-grade serous carcinoma between 2004 and 2012. The primary outcome of the study was mortality rate by hospital volume...
July 7, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28687398/the-impact-of-comorbidities-on-the-benefits-of-prolonged-androgen-ablation-in-patients-with-t3-4-prostate-cancer-treated-with-external-beam-radiation-therapy
#12
Eric Tran, Matthew Paquette, Justin Jay, Jeremy Hamm, Mitchell Liu, Graeme Duncan, Tom Pickles, Scott Tyldesley
PURPOSE: To determine whether the survival benefit associated with prolonged androgen deprivation therapy (ADT) and radiotherapy (EBRT) varies with baseline estimates of overall survival in cT3-4 prostate cancer patients (PCa). METHODS AND MATERIALS: In 1997, the BC Cancer Agency adopted as standard a policy of prolonged ADT (>18months) with EBRT for locally advanced PCa. Two cohorts of cT3-T4 PCa treated with EBRT were selected: 1993-1995 (early: N=725) and 1999-2001 (late: N=584)...
July 4, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28685896/comorbidity-dependent-adherence-to-guidelines-and-survival-in-breast-cancer-is-there-a-role-for-guideline-adherence-in-comorbid-breast-cancer-patients-a-retrospective-cohort-study-with-2137-patients
#13
Daniel Wollschläger, Xiaoyu Meng, Achim Wöckel, Wolfgang Janni, Rolf Kreienberg, Maria Blettner, Lukas Schwentner
In the treatment of breast cancer, decisions on adjuvant treatment reflect individual patient characteristics like age and comorbidity. This study assessed the association between adherence to guidelines for adjuvant treatment and survival while taking into account age at diagnosis and comorbidities. We collected the Charlson comorbidity index at baseline for 2179 women treated for primary breast cancer from 1992 to 2008 who participated in a German retrospective multicenter cohort study. We assessed subsequent adjuvant therapy guideline adherence and survival in relation to baseline comorbidities...
July 7, 2017: Breast Journal
https://www.readbyqxmd.com/read/28683820/primary-radio-chemo-therapy-for-esophageal-cancer-in-elderly-patients-are-efficiency-and-toxicity-comparable-with-younger-patients
#14
Stefan Münch, Christine Heinrich, Daniel Habermehl, Markus Oechsner, Stephanie E Combs, Marciana-Nona Duma
PURPOSE: In elderly patients with esophageal cancer (EC), esophagectomy is associated with an increased mortality, and therefore these patients are often treated with definite (chemo)radiation. The purpose of this study was to assess the toxicity and efficiency of definite radio(chemo)therapy in patients >75 years compared with definite radio(chemo)therapy in patients <75 years. METHODS: 32 patients >75 years were treated with definite radio(chemo)therapy for EC...
July 6, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/28683802/adverse-events-and-in-hospital-mortality-an-analysis-of-all-deaths-in-a-norwegian-health-trust-during-2011
#15
Hans Flaatten, Guttorm Brattebø, Bjørn Alme, Kjersti Berge, Jan H Rosland, Asgaut Viste, Bjørn Bertelsen, Stig Harthug, Sidsel Aardal
BACKGROUND: The estimated number of in-hospitals deaths due to adverse events is often different when using data from deceased patients compared with that of a population experiencing adverse events. METHODS: The study was conducted at three hospitals in the Bergen Hospital Trust, including a 950-bed university hospital. The objective was to study the reported deaths and investigate the probable number of deaths caused by adverse events. Information about all patients who died in the hospitals during 2011 was retrieved from the electronic patient data management system and the medical records...
July 6, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28679184/influence-of-hiv-virus-in-the-hospital-stay-and-the-occurrence-of-postoperative-complications-classified-according-to-the-clavien-dindo-classification-and-in-comparison-with-the-charlson-comorbidity-index-in-patients-subjected-to-urologic-and-general-surgery
#16
Dimitrios Dimitroulis, Georgios Karaolanis, Ioannis Katafigiotis, Ioannis Anastasiou, Viktoria-Varvara Palla, Athanasios Kontos, Mordechai Duvdevani, Konstantinos Kontzoglou
OBJECTIVES: From the first time that human immunodeficiency virus (HIV) was discovered, till today both the quality of life and survival expectancy of HIV-infected patients have markedly improved. As the life expectancy of these patients increases due to the use of highly active anti-retroviral therapy (HAART) also increases the number of HIV-positive patient to be subjected to an operation. Different studies have examined the occurrence of complications in this particular group of patients and their possible susceptibility to infections or other complications that could lead to increased hospital stay, morbidity and mortality with controversial results...
June 30, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28675571/five-year-survival-after-surgery-in-nonagenarian-patients
#17
Roberto Fariña-Castro, Cristina Roque-Castellano, Joaquín Marchena-Gómez, Aurelio Rodríguez-Pérez
AIM: In countries with longer life expectancies, the nonagenarian population is increasing. Therefore, there is greater demand for healthcare, including surgical procedures. The aim of the present study was to determine the outcomes of surgery carried out on nonagenarians in terms of long-term survival after the procedure. METHODS: We carried out a cross-longitudinal study on a cohort of 159 nonagenarian patients, who underwent a non-cardiac, non-traumatic surgical procedure in our institution between January 1999 and December 2011...
July 4, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28669704/low-pressure-robot-assisted-radical-prostatectomy-with-the-airseal-system-at-olv-hospital-results-from-a-prospective-study
#18
Sabrina La Falce, Giacomo Novara, Giorgio Gandaglia, Paolo Umari, Geert De Naeyer, Frederiek D'Hondt, Jean Beresian, Rik Carette, Martin Penicka, Yujiing Mo, Geert Vandenbroucke, Alexandre Mottrie
BACKGROUND: Limited studies examined effects of pneumoperiotneum during robot-assisted radical prostatectomy (RARP) and with AirSeal. The aim of this study was to assess the effect on hemodynamics of a lower pressure pneumoperitoneum (8 mmHg) with AirSeal, during RARP in steep Trendelenburg 45° (ST). MATERIALS AND METHODS: This is an institutional review board-approved, prospective, interventional, single-center study including patients treated with RARP at OLV Hospital by one extremely experienced surgeon (July 2015-February 2016)...
June 2, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28668927/delirium-after-transcatheter-aortic-valve-replacement
#19
Jennifer L Giuseffi, Nyal E Borges, Leanne M Boehm, Li Wang, John A McPherson, Joseph L Fredi, Rashid M Ahmad, E Wesley Ely, Pratik P Pandharipande
BACKGROUND: Postoperative delirium is associated with increased mortality. Patients undergoing transcatheter aortic valve replacement are at risk for delirium because of comorbid conditions. OBJECTIVE: To compare the incidence, odds, and mortality implications of delirium between patients undergoing transcatheter replacement and patients undergoing surgical replacement. METHODS: The Richmond Agitation-Sedation Scale and the Confusion Assessment Method for the Intensive Care Unit were used to assess arousal level and delirium prospectively in all patients with severe aortic stenosis who had transcatheter or surgical aortic valve replacement at an academic medical center...
July 2017: American Journal of Critical Care: An Official Publication, American Association of Critical-Care Nurses
https://www.readbyqxmd.com/read/28667319/infection-is-an-independent-predictor-of-death-in-diffuse-large-b-cell-lymphoma
#20
Claire Dendle, Michael Gilbertson, Tim Spelman, Rhonda L Stuart, Tony M Korman, Karin Thursky, Stephen Opat, Zoe McQuilten
To identify risk factors for infection in patients with diffuse large B cell lymphoma (DLBCL) undergoing rituximab, cyclophosphamide, vincristine, adriamycin and prednisolone (R-CHOP) treatment. All patients with DLBCL who received R-CHOP from 2004-2014 in a tertiary Australian hospital were identified and information collected from hospital admission data, laboratory results and medical record review. Infection was defined as hospitalisation with an ICD-10-AM diagnostic code for infection. Risk factors for infection and association between infection and survival were modelled using Cox proportional hazards regression...
June 30, 2017: Scientific Reports
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