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Charlson's comorbidity-age index

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https://www.readbyqxmd.com/read/29231962/symptoms-reported-by-frail-elderly-adults-independently-predict-30-day-hospital-readmission-or-emergency-department-care
#1
Lynn S Borkenhagen, Rozalina G McCoy, Rachel D Havyer, Stephanie M Peterson, James M Naessens, Paul Y Takahashi
OBJECTIVES: To assess the degree to which self-reported symptoms predict unplanned readmission or emergency department (ED) care within 30 days of high-risk, elderly adults enrolled in a posthospitalization care transition program (CTP). DESIGN: Retrospective cohort study. SETTING: Posthospitalization CTP at Mayo Clinic, Rochester, Minnesota, from January 1, 2013, through March 3, 2015. PARTICIPANTS: Frail, elderly adults (N = 230; mean age 83...
December 12, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29231750/concordance-with-prescribing-information-dosage-recommendations-for-dipeptidyl-peptidase-4-inhibitors-among-type-2-diabetes-mellitus-patients-with-moderate-to-severe-chronic-kidney-disease
#2
Huan Huang, Sharash Shetty, Elise Bauer, Kathleen Lang
OBJECTIVE: To estimate the proportion of patients with moderate to severe chronic kidney disease (CKD) whose initial DPP4-i dosage was concordant with prescribing information (label) recommendations in the United States. METHODS: Adult patients with T2DM who initiated a DPP4-i (linagliptin, sitagliptin, saxagliptin) between Jan 1, 2011 and Jun 30, 2014 were identified using electronic medical records and administrative claims, with index date being the date of first observed DPP4-i treatment...
December 12, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29230534/the-burden-of-comorbidity-and-complexity-in-sarcoidosis-impact-of-associated-chronic-diseases
#3
Pilar Brito-Zerón, Nihan Acar-Denizli, Antoni Sisó-Almirall, Xavier Bosch, Fernanda Hernández, Sergi Vilanova, Mireia Villalta, Belchin Kostov, Marina Paradela, Marcelo Sanchez, José Ramírez, Africa Muxí, Antonio Berruezo, Celeste Galceran-Chaves, Antoni Xaubet, Carles Agustí, Jacobo Sellarés, Manuel Ramos-Casals
PURPOSE: To evaluate comorbidity, complexity and poor outcomes in patients with sarcoidosis and to compare those scores with a control group. METHODS: 218 consecutive patients were diagnosed with sarcoidosis according to the ATS/ERS/WASOG criteria; extrathoracic involvement was evaluated using the 2014 WASOG organ assessment instrument. Sarcoidosis patients were compared with an age- and gender-matched control group of primary care outpatients without sarcoidosis...
December 11, 2017: Lung
https://www.readbyqxmd.com/read/29228124/association-of-estimated-glomerular-filtration-rate-with-muscle-function-in-older-persons-who-have-fallen
#4
Lisanne Tap, Nicole D A Boyé, Klaas A Hartholt, Tischa J M van der Cammen, Francesco U S Mattace-Raso
Background: studies suggest that estimated glomerular filtration rate (eGFR) is less reliable in older persons and that a low serum-creatinine might reflect reduced muscle mass rather than high kidney function. This study investigates the possible relationship between eGFR and multiple elements of physical performance in older fallers. Methods: baseline data of the IMPROveFALL-study were examined in participants ≥65 years. Serum-creatinine based eGFR was classified as normal (≥90 ml/min), mildly reduced (60-89 ml/min) or moderately-severely reduced (<60 ml/min)...
December 8, 2017: Age and Ageing
https://www.readbyqxmd.com/read/29225254/observational-study-of-infective-endocarditis-at-a-community-based-hospital-dominance-of-elderly-patients-with-comorbidity
#5
Tomoo Nagai, Yoshiyuki Takase, Akira Hamabe, Hirotsugu Tabata
Objective The purpose of this study was to present the recent clinical profiles and the real-world management of infective endocarditis (IE). Methods All medical records of patients with IE were reviewed retrospectively for their clinical data, including clinical presentation, laboratory results, blood cultures, echocardiographic findings, treatments and complications. Using the clinical data collected, we calculated the EuroSCORE II, the European risk score for adult cardiac surgery, the Charlson Comorbidity Index as a surrogate of comordibity, and the Katz Index as a surrogate of frailty...
December 8, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29221489/characteristics-of-the-use-of-cold-combination-products-among-older-ambulatory-patients-at-the-national-hospital-organization-tochigi-medical-center-in-japan-a-retrospective-single-center-observational-study
#6
Junpei Komagamine
OBJECTIVE: This study aimed to determine the frequency and characteristics of prescriptions of cold combination products among older ambulatory patients. A retrospective observational study was conducted using electronic medical records. All patients aged 65 years or older who continued visiting internal medicine physicians for at least 1 year were included. The primary outcome was the prescription of cold combination products by any physicians in National Hospital Organization Tochigi Medical Center during a 1-year follow-up...
December 8, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29221273/clinical-outcomes-of-video-assisted-thoracoscopic-surgery-esophagectomy-for-esophageal-cancer-a-propensity-score-matched-analysis
#7
Duk Hwan Moon, Jong Mog Lee, Jae Hyun Jeon, Hee Chul Yang, Moon Soo Kim
Background: Minimally invasive esophagectomy theoretically offers advantages compared with open esophagectomy (OE). The aim of this study was to compare the early- and mid-term outcomes between video-assisted thoracoscopic surgery (VATS) esophagectomy (VE) and OE in patients with esophageal cancer. Methods: Between November 2011 and July 2015, a total of 172 patients were divided into two groups depending on the method of esophagectomy: the VE group (n=42) and the OE group (n=130)...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29218388/correlation-of-sociodemographic-and-clinical-parameters-with-depression-and-distress-in-patients-with-hematologic-malignancies
#8
Amanda J Shreders, Shehzad K Niazi, David O Hodge, Nicolette T Chimato, Megha Kureti, Navya Kirla, Ankit Agrawal, Abhisek Swaika, Elaine Gustetic, Renee Foster, Kimberly A Nelson, Prachi Jani, Asher A Chanan-Khan, Sikander Ailawadhi
A quarter of cancer patients struggle with distress or depression during their illness. Multiple organizations including the National Comprehensive Cancer Network recommend universal screening for distress and depression. Herein, we describe a universal screening program in patients with hematologic malignancies and factors associated with distress and depression. Between December 2013 and February 2015, patients with hematologic malignancies took the Patient Health Questionnaire 9 (PHQ-9) and Distress Thermometer (DT) prior to receiving their first outpatient parenteral chemotherapy...
December 7, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/29215534/incidence-and-predictors-of-readmissions-in-acute-pancreatitis-a-nationwide-analysis
#9
Sushil Kumar Garg, James P Campbell, Chimaobi Anugwom, Vaibhav Wadhwa, Rajeshwar Singh, Nancy Gupta, Madhusudhan R Sanaka
OBJECTIVES: Acute pancreatitis (AP) is a common cause for hospitalization, and readmission is common, with variable associated risk factors for readmission. Here, we assessed the incidence and risk factors for readmission in AP in a large national database. METHODS: We analyzed data from the National Readmission Database during the year 2013. Index admissions with a primary discharge diagnosis of AP using the International Classification of Diseases, Ninth Revision, Clinical Modification were identified from January to November to identify 30-day readmission rates...
December 5, 2017: Pancreas
https://www.readbyqxmd.com/read/29214512/anticholinergic-prescribing-in-medicare-part-d-beneficiaries-residing-in-nursing-homes-results-from-a-retrospective-cross-sectional-analysis-of-medicare-data
#10
Joshua Niznik, Xinhua Zhao, Tao Jiang, Joseph T Hanlon, Sherrie L Aspinall, Joshua Thorpe, Carolyn Thorpe
BACKGROUND: Prescribing of medications with anticholinergic properties in older nursing home residents is relatively common, despite an association with an increased risk for falls, delirium, and other outcomes. Few studies have investigated what factors influence different levels of prescribing of these agents. OBJECTIVES: The primary objective was to identify factors associated with low- and high-level anticholinergic burden in nursing home residents. A secondary objective was to examine in detail the contribution of different medications to low versus high burden to aid in determining which drugs to target in interventions...
December 6, 2017: Drugs & Aging
https://www.readbyqxmd.com/read/29208310/equivalent-mortality-and-complication-rates-following-periprosthetic-distal-femur-fractures-managed-with-either-lateral-locked-plating-or-a-distal-femoral-replacement
#11
Jason S Hoellwarth, Mitchell S Fourman, Lawrence Crossett, Mark Goodman, Peter Siska, Gele B Moloney, Ivan S Tarkin
INTRODUCTION: Management of distal femur fractures above total knee arthroplasty (TKA) remains challenging. Two common surgical options are locked lateral plating (LLP) and distal femoral arthroplasty (DFR). Unfortunately, approximately 30-50% of patients may die within one year of injury, require further surgery, or not regain prior mobility performance. We compared 87 LLP to 53 DFR patients - to our knowledge the largest comparative study - focusing on 90- and 365-day mortality, mobility maintenance, and further surgery...
December 1, 2017: Injury
https://www.readbyqxmd.com/read/29206787/outpatient-total-knee-arthroplasty-is-associated-with-higher-risk-of-perioperative-complications
#12
Armin Arshi, Natalie L Leong, Anthony D'Oro, Christopher Wang, Zorica Buser, Jeffrey C Wang, Kristofer J Jones, Frank A Petrigliano, Nelson F SooHoo
BACKGROUND: As concerns regarding health-care expenditure in the U.S. remain at the national forefront, outpatient arthroplasty is an appealing option for carefully selected patient populations. The purpose of this study was to determine the nationwide trends and complication rates associated with outpatient total knee arthroplasty (TKA) in comparison with standard inpatient TKA. METHODS: We performed a retrospective review of the Humana subset of the PearlDiver Patient Record Database to identify patients who had undergone TKA (Current Procedural Terminology [CPT] code 27447) as either outpatients or inpatients from 2007 to 2015...
December 6, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29198873/short-and-long-term-postoperative-complications-following-total-joint-arthroplasty-in-patients-with-human-immunodeficiency-virus-hepatitis-b-or-hepatitis-c
#13
Beau J Kildow, Cary S Politzer, Marcus DiLallo, Michael P Bolognesi, Thorsten M Seyler
INTRODUCTION: Due to advancement in treatment against human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV), the prevalence of this patient population electing to undergo total joint arthroplasty (TJA) is increasing. Current literature is scarce and conflicting especially when evaluating long-term surgical complications. The purpose of this study is to assess the postoperative medical and surgical complications following TJA in these patient populations...
November 13, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29198510/does-calculated-free-testosterone-overcome-total-testosterone-in-protecting-from-sexual-symptom-impairment-findings-of-a-cross-sectional-study
#14
Luca Boeri, Paolo Capogrosso, Eugenio Ventimiglia, Walter Cazzaniga, Filippo Pederzoli, Donatella Moretti, Federico Dehò, Emanuele Montanari, Francesco Montorsi, Andrea Salonia
BACKGROUND: Although erectile dysfunction (ED) has been associated with low circulating total testosterone (TT) levels, the utility of free testosterone (FT) over TT is debatable. AIM: To assess the relative impact of low TT and low calculated FT (cFT) on androgen-related sexual symptoms in men with ED. METHODS: Data from 485 men were analyzed. Comorbidities were scored with the Charlson Comorbidity Index (CCI). Patients completed the International Index of Erectile Function (IIEF) and the Beck Inventory for Depression (BDI)...
December 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29192933/short-term-outcomes-of-total-knee-arthroplasty-performed-at-an-orthopedic-specialty-hospital
#15
Eric M Padegimas, Tyler M Kreitz, Benjamin Zmistowski, Seth L Teplitsky, Surena Namdari, James J Purtill, William J Hozack, Antonia F Chen
This study compared perioperative outcomes for total knee arthroplasty (TKA) at an orthopedic specialty hospital and a tertiary referral center. The authors identified all primary TKA procedures performed in 2014 at the 2 facilities. Each patient at the orthopedic specialty hospital was manually matched to a patient at the tertiary referral center according to demographic and clinical variables. Matching was blinded to outcomes. Outcomes were 90-day readmission, mortality rate, reoperation, length of stay, and use of inpatient rehabilitation...
November 30, 2017: Orthopedics
https://www.readbyqxmd.com/read/29191070/predictors-of-mortality-in-nondemented-patients-with-parkinson-disease-motor-symptoms-versus-nonmotor-symptoms
#16
D Santos-García, E Suárez-Castro, J Ernandez, I Expósito-Ruiz, C Tuñas-Gesto, M Aneiros-Díaz, T de Deus-Fonticoba, M López-Fernández, D Núñez-Arias
BACKGROUND AND OBJECTIVE: The aim of this study is to identify risk factors for mortality in a community-based cohort of nondemented patients with Parkinson disease (PD) during prospective long-term follow-up, while also comparing the effect of motor complications to nonmotor symptoms (NMS) on risk of mortality. METHODS: One hundred forty seven nondemented patients with PD (57.1% males; 70.9 ± 8.6 years old) were included in this 48 month follow-up, longitudinal, single, evaluation study...
January 1, 2017: Journal of Geriatric Psychiatry and Neurology
https://www.readbyqxmd.com/read/29189600/pharmacoeconomic-and-associated-cost-savings-among-women-who-were-prescribed-systemic-conjugated-estrogens-therapy-compared-with-those-without-menopausal-therapy
#17
Wing Yu Tang, Dale Grothe, Allison Keshishian, Diana Morgenstern, Seema Haider
OBJECTIVE: To explore changes in healthcare costs among postmenopausal women in a commercial population who were prescribed conjugated estrogens for menopausal symptoms. METHODS: Using the MarketScan dataset from April 1, 2008 through September 30, 2012, postmenopausal women aged ≥45 years, who were prescribed conjugated estrogen tablets (Premarin), were identified. A comparative cohort of postmenopausal women with vasomotor symptoms without any menopause therapy was also identified...
November 20, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29189383/sinai-abbreviated-geriatric-evaluation-development-and-validation-of-a-practical-test
#18
Mark R Katlic, JoAnn Coleman, Kamran Khan, Susan E Wozniak, Joseph H Abraham
OBJECTIVE: To develop and validate a simple geriatric screening tool that performs as well as more complex assessments BACKGROUND:: Many tools that predict treatment risk in older adults are impractical for routine clinical use. METHODS: We prospectively conducted comprehensive preoperative evaluations on 1025 patients age ≥75 years who presented to Sinai Hospital of Baltimore for major elective surgery, then retrospectively reviewed patients' medical records for occurrence of postoperative outcomes...
November 16, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/29188319/a-dedicated-paracentesis-clinic-decreases-healthcare-utilization-for-serial-paracenteses-in-decompensated-cirrhosis
#19
Yao-Wen Cheng, Kumar Sandrasegaran, Katherine Cheng, Angela Shah, Marwan Ghabril, William Berry, Craig Lammert, Naga Chalasani, Eric S Orman
PURPOSE: The purpose of the study is to describe the effect of a dedicated paracentesis clinic on healthcare utilization by patients with decompensated cirrhosis and refractory ascites. METHODS: This Institutional Review Board-approved retrospective study identified cirrhotic patients receiving paracenteses over a 6-month period before and after creating the paracentesis clinic. Patients were followed for 12 months to collect outcome data including characteristics of subsequent hospitalizations and paracenteses...
November 29, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/29184135/impact-of-visceral-fat-on-surgical-complications-and-long-term-survival-of-patients-with-gastric-cancer-after-radical-gastrectomy
#20
Su-Lin Wang, Liang-Liang Ma, Xi-Yi Chen, Dong-Lei Zhou, Bo Li, Dong-Dong Huang, Zhen Yu, Xian Shen, Cheng-Le Zhuang
BACKGROUND/OBJECTIVES: The aim of this study was to examine the impact of visceral fat on surgical complications and long-term survival for patients undergoing radical gastrectomy. SUBJECTS/METHODS: From 2009 to 2013, 859 patients who underwent curative resection for gastric cancer were enrolled from a prospectively maintained database. Visceral fat area (VFA) was assessed by preoperative CT scans. Patients were divided into two groups by VFA. Perioperative variables and postoperative outcomes were compared between the high VFA group and low VFA group...
November 29, 2017: European Journal of Clinical Nutrition
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