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Charlson's comorbidity-age index

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https://www.readbyqxmd.com/read/28095268/impact-of-increasing-age-on-cause-specific-mortality-and-morbidity-in-patients-with-stage-i-non-small-cell-lung-cancer-a-competing-risks-analysis
#1
Takashi Eguchi, Sarina Bains, Ming-Ching Lee, Kay See Tan, Boris Hristov, Daniel H Buitrago, Manjit S Bains, Robert J Downey, James Huang, James M Isbell, Bernard J Park, Valerie W Rusch, David R Jones, Prasad S Adusumilli
Purpose To perform competing risks analysis and determine short- and long-term cancer- and noncancer-specific mortality and morbidity in patients who had undergone resection for stage I non-small-cell lung cancer (NSCLC). Patients and Methods Of 5,371 consecutive patients who had undergone curative-intent resection of primary lung cancer at our institution (2000 to 2011), 2,186 with pathologic stage I NSCLC were included in the analysis. All preoperative clinical variables known to affect outcomes were included in the analysis, specifically, Charlson comorbidity index, predicted postoperative (ppo) diffusing capacity of the lung for carbon monoxide, and ppo forced expiratory volume in 1 second...
January 20, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28093437/risk-of-sepsis-in-patients-with-amyotrophic-lateral-sclerosis-a-population-based-retrospective-cohort-study-in-taiwan
#2
Cynthia Wei-Sheng Lee, Hsuan-Ju Chen, Ji-An Liang, Chia-Hung Kao
OBJECTIVES: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, and sepsis is a frequent cause of death in hospitalised patients. We investigated the relationship between ALS and the subsequent risk of sepsis. DESIGN: A retrospective cohort analysis. SETTING: Patients with ALSs diagnosed between 2000 and 2010 in Taiwan National Health Insurance Research Database. PARTICIPANTS: We included 701 and 2804 patients as the ALS and the non-ALS groups, respectively...
January 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/28092760/serum-brain-derived-neurotrophic-factor-and-stability-of-depressive-symptoms-in-coronary-heart-disease-patients-a-prospective-study
#3
Stella L Kuhlmann, Mira Tschorn, Volker Arolt, Katja Beer, Julia Brandt, Laura Grosse, Wilhelm Haverkamp, Jacqueline Müller-Nordhorn, Nina Rieckmann, Johannes Waltenberger, Katharina Warnke, Rainer Hellweg, Andreas Ströhle
OBJECTIVE: Brain-derived neurotrophic factor (BDNF) supports neurogenesis, angiogenesis, and promotes the survival of various cell types in the brain and the coronary system. Moreover, BDNF is associated with both coronary heart disease (CHD) and depression. The current study aims to investigate whether serum BDNF levels are associated with the course of depressive symptoms in CHD patients. METHODS: At baseline, N=225 CHD patients were enrolled while hospitalized...
December 23, 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28091402/geriatric-assessment-to-predict-survival-and-risk-of-serious-adverse-events-in-elderly-newly-diagnosed-multiple-myeloma-patients-a-multicenter-study-in-china
#4
Yu-Ping Zhong, Yi-Zhuo Zhang, Ai-Jun Liao, Su-Xia Li, Chen Tian, Jin Lu
BACKGROUND: Elderly multiple myeloma (MM) patients often tend to suffer a variety of diseases, so the treatment of choice is very difficult for the elderly myeloma patients. The overall survival (OS) time and side effects with elderly patients are unclear in China. The study tried to find out the role of geriatric assessment in the Chinese elderly MM. METHODS: We retrospectively analyzed the data of 628 newly diagnosed patients from six hospitals from June 2011 to June 2013...
2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28090345/electronically-captured-patient-reported-physical-function-an-important-vital-sign-in-obesity-medicine
#5
J Fleming, G C Wood, C Seiler, A Cook, M R Lent, C D Still, P N Benotti, B A Irving
OBJECTIVES: Impaired physical function (i.e., inability to walk 200 feet, climb a flight of stairs or perform activities of daily living) predicts poor clinical outcomes and adversely impacts medical and surgical weight management. However, routine assessment physical function is seldom performed clinically. The PROMIS Physical Function Short Form 20a (SF-20a) is a validated questionnaire for assessing patient reported physical function, which includes published T-score percentiles adjusted for gender, age and education...
December 2016: Obesity Science & Practice
https://www.readbyqxmd.com/read/28089151/influenza-vaccination-reduces-hemorrhagic-stroke-risk-in-patients-with-atrial-fibrillation-a-population-based-cohort-study
#6
Ju-Chi Liu, Ta-Jung Wang, Li-Chin Sung, Pai-Feng Kao, Tsung-Yeh Yang, Wen-Rui Hao, Chun-Chao Chen, Yi-Ping Hsu, Szu-Yuan Wu
PURPOSE: The risk of hemorrhagic stroke in patients with atrial fibrillation (AF) is low but the consequences of its occurrence are extremely severe. In this study, we investigated the association of influenza vaccination with the risk of hemorrhagic stroke to develop an efficient strategy for reducing this risk in patients with AF. METHODS: In this study, data were retrieved from the Taiwan National Health Insurance Research Database. The study cohort comprised all patients who received a diagnosis of AF (n=14,454) before January 1, 2005 (index date) and were followed until December 31, 2012...
December 21, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/28086826/offering-patients-therapy-options-in-unplanned-start-options-implementation-of-an-educational-program-is-feasible-and-effective
#7
Anna Machowska, Mark Dominik Alscher, Satyanarayana Reddy Vanga, Michael Koch, Michael Aarup, Abdul Rashid Qureshi, Bengt Lindholm, Peter Rutherford
BACKGROUND: Patients with unplanned dialysis start (UPS) have worse clinical outcomes than non-UPS patients, and receive peritoneal dialysis (PD) less frequently. In the OPTiONS study of UPS patients, an educational programme (UPS-EP) aiming at improving care of UPS patients by facilitating care pathways and enabling informed choice of dialysis modality was implemented. We here report on impact of UPS-EP on modality choice and clinical outcomes in UPS patients. METHODS: This non-interventional, prospective, multi-center, observational study included 270 UPS patients from 26 centers in 6 European countries (Austria, Germany, Denmark, France, United Kingdom and Sweden) who prior to inclusion presented acutely, or were being followed by nephrologists but required urgent dialysis commencement by an acutely placed CVC or PD catheter...
January 13, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28081205/anxiety-and-depression-in-patients-with-traumatic-spinal-cord-injury-a-nationwide-population-based-cohort-study
#8
Sher-Wei Lim, Yow-Ling Shiue, Chung-Han Ho, Shou-Chun Yu, Pei-Hsin Kao, Jhi-Joung Wang, Jinn-Rung Kuo
BACKGROUND: Traumatic spinal cord injury (tSCI) may involve new-onset anxiety and depression post-discharge. However, long-term population-based studies have lacked access to follow-up conditions in terms of new-onset anxiety and depression. The objective of this study was to estimate the long-term risk of new-onset anxiety and depression post-discharge. METHODS: The Longitudinal Health Insurance Database 2000 (LHID2000) from Taiwan's National Health Insurance Research Database was used in this study...
2017: PloS One
https://www.readbyqxmd.com/read/28079594/impact-of-concurrent-medication-use-on-pancreatic-cancer-survival-seer-medicare-analysis
#9
Muhammad S Beg, Arjun Gupta, David Sher, Sadia Ali, Saad Khan, Ang Gao, Tyler Stewart, Chul Ahn, Jarett Berry, Eric M Mortensen
OBJECTIVES: Preclinical studies have suggested that non-antineoplastic medication use may impact pancreatic cancer biology. We examined the association of several medication classes on pancreatic cancer survival in a large medical claims database. MATERIALS AND METHODS: Histologically confirmed pancreatic adenocarcinoma diagnosed between 2006 and 2009 were analyzed from the Surveillance, Epidemiology, and End Results-Medicare database with available part D data...
January 10, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28065660/time-trends-in-incidence-and-outcomes-of-hospitalizations-for-aspiration-pneumonia-among-elderly-people-in-spain-2003-2013
#10
Domingo Palacios-Ceña, Valentín Hernández-Barrera, Ana López-de-Andrés, César Fernández-de-Las-Peñas, María Palacios-Ceña, Javier de Miguel-Díez, Pilar Carrasco-Garrido, Rodrigo Jiménez-García
BACKGROUND: Aspiration pneumonia (AP) is an infectious process causing high rates of mortality. The purpose of this study was: 1, to describe the incidence from 2003 to 2013 of AP hospitalizations; 2, to assess time trends in hospital outcomes variables, and; 3, to identify the factors independently associated with in-hospital mortality (IHM). METHODS: A retrospective observational study using the Spanish National Hospital Database, with patients discharged between January 2003 and December 2013 was conducted...
January 5, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28062372/uric-acid-may-be-protective-against-cognitive-impairment-in-older-adults-but-only-in-those-without-cardiovascular-risk-factors
#11
Busra Tuven, Pinar Soysal, Gulcin Unutmaz, Derya Kaya, Ahmet Turan Isik
Uric acid (UA) may not only prevent development of cognitive dysfunction owing to its antioxidant efficacy, but also may worsen cognitive functions by gaining pro-oxidant character. The present study attempts to uncover this paradoxical association between UA and cognitive impairment in elderly. 1374 elderly patients were retrospectively evaluated and included in the study. Participants underwent determination of circulating UA levels and comprehensive geriatric assessment. A serum UA concentration≥7.0mg/dL in males and ≥5...
January 3, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28061757/comparison-of-risk-adjustment-methods-in-patients-with-liver-disease-using-electronic-medical-record-data
#12
Yuan Xu, Ning Li, Mingshan Lu, Elijah Dixon, Robert P Myers, Rachel J Jolley, Hude Quan
BACKGROUND: Risk adjustment is essential for valid comparison of patients' health outcomes or performances of health care providers. Several risk adjustment methods for liver diseases are commonly used but the optimal approach is unknown. This study aimed to compare the common risk adjustment methods for predicting in-hospital mortality in cirrhosis patients using electronic medical record (EMR) data. METHODS: The sample was derived from Beijing YouAn hospital between 2010 and 2014...
January 7, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28059982/morbidity-of-adult-spinal-deformity-surgery-in-elderly-has-declined-over-time
#13
Peter G Passias, Gregory W Poorman, Cyrus M Jalai, Brian Neuman, Rafael de la Garza-Ramos, Emily Miller, Amit Jain, Daniel Sciubba, Shearwood McClelland, Louis Day, Subbu Ramachadran, Shaleen Vira, Bassel Diebo, Evan Isaacs, Olivia Bono, Shay Bess, Michael Gerling, Virginie Lafage
STUDY DESIGN: A retrospective review of a prospectively collected database, the Nationwide Inpatient Sample (NIS), years 2003 to 2012. OBJECTIVES: The aim of this study was to examine trends in the management of scoliosis in elderly (age >75 yrs) patients from 2003 to 2012. SUMMARY OF BACKGROUND DATA: Scoliosis incidence rises with increasing age, and age has been shown to be an independent risk factor for surgical complications in scoliosis surgery...
January 4, 2017: Spine
https://www.readbyqxmd.com/read/28059966/readmission-after-ileostomy-creation-retrospective-review-of-a-common-and-significant-event
#14
Daniel R Fish, Carol A Mancuso, Julio E Garcia-Aguilar, Sang W Lee, Garrett M Nash, Toyooki Sonoda, Mary E Charlson, Larissa K Temple
OBJECTIVE: To evaluate causes and predictors of readmission after new ileostomy creation. BACKGROUND: New ileostomates have been reported to have higher readmission rates compared with other surgical patients, but data on predictors are limited. METHODS: A total of 1114 records at 2 associated hospitals were reviewed to identify adults undergoing their first ileostomy. Primary outcome was readmission within 60 days of surgery. Multiple logistic regression was used to identify independent predictors; area under the receiver-operator characteristic curves (AUC) were used to evaluate age-stratified models in secondary analysis...
February 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28058848/implantable-cardioverter-defibrillator-and-survival-after-out-of-hospital-cardiac-arrest-due-to-acute-myocardial-infarction-in-denmark-in-the-years-2001-2012-a-nationwide-study
#15
Matilde Winther-Jensen, Jesper Kjaergaard, Jens F Lassen, Lars Køber, Christian Torp-Pedersen, Steen M Hansen, Freddy Lippert, Kristian Kragholm, Erika F Christensen, Christian Hassager
AIM: The purpose of this study was to describe the implantation of implantable cardioverter defibrillator after out-of-hospital cardiac arrest caused by myocardial infarction in Denmark 2001-2012 and subsequent survival. METHODS: The Danish Cardiac Arrest Registry was used to identify patients ⩾18 years surviving to discharge without prior implantable cardioverter defibrillator. Information on cardioverter defibrillator implantation was obtained from the National Patient Registry...
January 1, 2017: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/28053514/clinical-outcome-and-predictors-of-adverse-events-of-an-enhanced-older-adult-psychiatric-liaison-service-rapid-assessment-interface-and-discharge-newport
#16
Inderpal Singh, Priya Fernando, Jane Griffin, Chris Edwards, Kathryn Williamson, Patrick Chance
BACKGROUND: Hospitals are currently admitting an increasing number of older people, and more than one-third could have an underlying mental health problem. The existing Older Adult Mental Health (OAMH) liaison service was increasingly unable to meet the escalating needs of older and frail patients. Therefore, the service was modernized and enhanced on an "invest-to-save" principle to provide a prompt holistic assessment for older adults with mental health problems. The objective of this study was a service evaluation to appraise clinical outcome, minimize the length of stay, and measure the predictors of adverse outcomes to streamline this enhanced service...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28045620/effectiveness-of-adjuvant-chemotherapy-after-radical-nephroureterectomy-for-locally-advanced-and-or-positive-regional-lymph-node-upper-tract-urothelial-carcinoma
#17
Thomas Seisen, Ross E Krasnow, Joaquim Bellmunt, Morgan Rouprêt, Jeffrey J Leow, Stuart R Lipsitz, Malte W Vetterlein, Mark A Preston, Nawar Hanna, Adam S Kibel, Maxine Sun, Toni K Choueiri, Quoc-Dien Trinh, Steven L Chang
Purpose There is limited evidence to support the use of adjuvant chemotherapy (AC) after radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC). Against this backdrop, we hypothesized that such treatment is associated with overall survival (OS) benefit in patients with locally advanced and/or positive regional lymph node disease. Patients and Methods Within the National Cancer Database (2004 to 2012), we identified 3,253 individuals who received AC or observation after RNU for pT3/T4 and/or pN+ UTUC...
January 3, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28040693/influence-of-statins-and-cholesterol-on-mortality-among-patients-with-pancreatic-cancer
#18
Brian Z Huang, Jonathan I Chang, Erica Li, Anny H Xiang, Bechien U Wu
BACKGROUND: Recent studies have suggested associations between statins and enhanced survival among patients with pancreatic ductal adenocarcinoma (PDAC). However, the relationship between statins, cholesterol, and survival remains unclear. METHODS: We conducted a retrospective cohort study on 2142 PDAC patients in a regional integrated healthcare system from 2006 to 2014. Electronic pharmacy records were used to abstract information on the type, length, and dosage of statin exposures starting in the year prior to diagnosis...
May 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28040280/management-and-outcome-of-patients-with-acute-myocardial-infarction-presenting-with-pacemaker-rhythm
#19
Noemi Bertel, Fabienne Witassek, Milo Puhan, Paul Erne, Hans Rickli, Barbara Naegeli, Giovanni Pedrazzini, Jean-Christophe Stauffer, Dragana Radovanovic
BACKGROUND: Diagnosis of acute myocardial infarction (MI) is challenging in pacemaker patients. Little is known about this patient group. METHODS: Patients with MI enrolled in the Swiss national AMIS Plus registry between January 2005 and December 2015 were analyzed. All patients with either paced ventricular rhythm or sinus rhythm with intrinsic ventricular conduction (IVC) were included in this study. Outcomes using crude data and propensity score matching were compared between patients with pacemaker rhythm and patients with IVC...
December 20, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/28039604/socioeconomic-and-racial-disparities-a-case-control-study-of-patients-receiving-transcatheter-aortic-valve-replacement-for-severe-aortic-stenosis
#20
Anna Sleder, Shiloh Tackett, Matthew Cerasale, Chetan Mittal, Iyad Isseh, Ryhm Radjef, Andrew Taylor, Rashad Farha, Oleksandra Lupak, Dana Larkin, Lois Lamerato, George Divine, Kimberlydawn Wisdom, Kimberly Baker-Genaw, William O'Neill
BACKGROUND: We sought to quantify socioeconomic disparities in patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR) at an urban, tertiary referral center. METHODS: This retrospective case-control study identified 67 patients with severe AS (aortic valve [AV] area ≤1 cm(2) or AV area index ≤0.60 cm(2)/m(2) or AV velocity ≥40 mmHg) who underwent TAVR from November 5, 2013 to June 10, 2014. Study subjects were matched to controls with severe AS without TAVR in a 4:1 age-frequency match...
December 30, 2016: Journal of Racial and Ethnic Health Disparities
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