keyword
https://read.qxmd.com/read/38462453/effect-of-dexamethasone-on-adhesion-of-human-neutrophils-and-concomitant-secretion
#21
JOURNAL ARTICLE
Svetlana I Galkina, Ekaterina A Golenkina, Natalia V Fedorova, Alexander L Ksenofontov, Marina V Serebryakova, Vladimir I Stadnichuk, Ludmila A Baratova, Galina F Sud'ina
Neutrophils play a dual role in protecting the body. They are able to penetrate infected tissues and destroy pathogens there by releasing aggressive bactericidal substances. While into the surrounding tissues, the aggressive products secreted by neutrophils initiate development of inflammatory processes. Invasion of neutrophils into tissues is observed during the development of pneumonia in the patients with lung diseases of various etiologies, including acute respiratory distress syndrome caused by coronavirus disease...
December 2023: Biochemistry. Biokhimii︠a︡
https://read.qxmd.com/read/38462120/versatile-chondroitin-sulfate-based-nanoplatform-for-chemo-photodynamic-therapy-against-triple-negative-breast-cancer
#22
JOURNAL ARTICLE
Jingmou Yu, Jing Xu, Renliang Jiang, Qinglan Yuan, Yuanyuan Ding, Jing Ren, Dengzhao Jiang, Yiqiu Wang, Liangliang Wang, Pu Chen, Lei Zhang
Versatile nanoplatform equipped with chemo-photodynamic therapeutic attributes play an important role in improving the effectiveness of tumor treatments. Herein, we developed multifunctional nanoparticles based on chondroitin sulfate A (CSA) for the targeted delivery of chlorin e6 (Ce6) and doxorubicin (DOX), in a combined chemo-photodynamic therapy against triple-negative breast cancer. CSA was chosen for its hydrophilic properties and its affinity to CD44 receptor-overexpressed tumor cells. The CSA-ss-Ce6 (CSSC) conjugate was synthesized utilizing a disulfide linker...
March 8, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38457892/new-insights-into-long-lasting-cr-vi-removal-from-groundwater-using-in-situ-biosulfidated-zero-valent-iron-with-sulfate-reducing-bacteria
#23
JOURNAL ARTICLE
Huichao Xu, Chuanyu Qin, Hui Zhang, Yongsheng Zhao
Sulfidation enhances the reactivity of zero-valent iron (ZVI) for Cr(VI) removal from groundwater. Current sulfidation methods mainly focus on chemical and mechanical sulfidation, and there has been little research on biosulfidation using sulfate-reducing bacteria (SRB) and its performance in Cr(VI) removal. Herein, the ability of the SRB-biosulfidated ZVI (SRB-ZVI) system was evaluated and compared with that of the Na2 S-sulfidated ZVI system. The SRB-ZVI system forms a thicker and more porous FeSx layer than the Na2 S-sulfidated ZVI system, resulting in more sufficient sulfidation of ZVI and a 2...
March 7, 2024: Journal of Environmental Management
https://read.qxmd.com/read/38455357/eno2-promotes-anoikis-resistance-in-anaplastic-thyroid-cancer-by-maintaining-redox-homeostasis
#24
JOURNAL ARTICLE
Yu Zhang, Xiaoyu Ji, Yu Wang
BACKGROUND: Anoikis presents a significant barrier in the metastasis of cancer. As the most aggressive type of thyroid cancer, anaplastic thyroid cancer (ATC) exhibits a high risk of metastasis and is characterized by high mortality. Therefore, investigating the molecular mechanisms of anoikis resistance in ATC is important for devising therapeutic targets in clinical research. METHODS: Differentially Expressed Genes were screened in ATC cells under attached and detached culture conditions with RNA-seq...
February 29, 2024: Gland Surgery
https://read.qxmd.com/read/38448587/oxidative-cyclization-reagents-reveal-tryptophan-cation-%C3%AF-interactions
#25
JOURNAL ARTICLE
Xiao Xie, Patrick J Moon, Steven W M Crossley, Amanda J Bischoff, Dan He, Gen Li, Nam Dao, Angel Gonzalez-Valero, Audrey G Reeves, Jeffrey M McKenna, Susanna K Elledge, James A Wells, F Dean Toste, Christopher J Chang
Methods for selective covalent modification of amino acids on proteins can enable a diverse array of applications, spanning probes and modulators of protein function to proteomics1-3 . Owing to their high nucleophilicity, cysteine and lysine residues are the most common points of attachment for protein bioconjugation chemistry through acid-base reactivity3,4 . Here we report a redox-based strategy for bioconjugation of tryptophan, the rarest amino acid, using oxaziridine reagents that mimic oxidative cyclization reactions in indole-based alkaloid biosynthetic pathways to achieve highly efficient and specific tryptophan labelling...
March 6, 2024: Nature
https://read.qxmd.com/read/38447955/type-2-diabetes-platelets-and-long-term-metabolic-control-as-estimated-from-glycosylated-haemoglobin-hba1c
#26
JOURNAL ARTICLE
M Edvardsson, M Oweling, P Järemo
In type 2 diabetes, platelets are likely affected by impaired long-term glycaemic control, but such pathophysiological links are poorly understood. This study thus compares platelet reactivity (i.e. agonist-evoked platelet reactions) in vitro with glycosylated haemoglobin (HbA1c), a measure commonly used for monitoring long-term metabolic control of type 2 diabetes. Elders with type 2 diabetes ( n  = 35) were divided according to HbA1c into groups (HbA1c-low and high) consisting of 17 and 18 subjects, respectively...
March 6, 2024: Hämostaseologie
https://read.qxmd.com/read/38444276/temperament-and-attachment-dimensions-as-predictors-for-impairments-of-personality-functioning-according-to-dsm-5
#27
JOURNAL ARTICLE
Małgorzata Machowicz, Jan Cieciuch
OBJECTIVES: The study aimed to assess the role of temperament and attachment dimensions for personality pathology defined as impairments in self- and interpersonal functioning according to Criterion A of Section III of the DSM-5. METHODS: The study was conducted in Poland with a group of 391 participants. The following measurement instruments were used: The Level of Personality Functioning Scale - Brief Form 2.0 (LPFS-BF 2.0), the Temperament Metadimensions Questionnaire (TMQ), the Attachment Style Questionnaire (ASQ), and the Experiences in Close Relationships - Revised (ECR-R)...
October 10, 2023: Psychiatria Polska
https://read.qxmd.com/read/38442039/function-of-the-ascorbate-peroxidase-apx-in-fruits-and-their-modulation-by-reactive-species
#28
JOURNAL ARTICLE
Francisco J Corpas, Salvador González-Gordo, José M Palma
Ascorbate peroxidase (APX) is one of the enzymes of the ascorbate-glutathione cycle and is the key enzyme that breaks down H2O2 with the aid of ascorbate as an electron source, although other enzymes also break down H2O2 such as catalase, peroxiredoxins, among others. APX is present in all photosynthetic eukaryotes from algae to higher plants and at the cellular level, it is localized in all subcellular compartments where H2O2 is generated, including apoplast, cytosol, plastids, mitochondria, and peroxisomes, either in soluble form or attached to the organelle membranes...
March 5, 2024: Journal of Experimental Botany
https://read.qxmd.com/read/38441736/effect-of-long-term-dry-wet-circulations-on-the-solidification-stabilization-of-municipal-solid-waste-incineration-fly-ash-using-a-novel-cementitious-material
#29
JOURNAL ARTICLE
Wei Deng, Pingfeng Fu, Jia Li, Xiaoli Wang, Yuliang Zhang
Solidification/stabilization (S/S) is a typical technique to immobilize toxic heavy metals in Municipal solid waste incineration fly ash (MSWI FA). This study utilized blast furnace slag, steel slag, desulfurization gypsum, and phosphoric acid sludge to develop a novel metallurgical slag based cementing material (MSCM). Its S/S effects of MSWI FA and long-term S/S effectiveness under dry-wet circulations (DWC) were evaluated and compared with ordinary Portland cement (OPC). The MSCM-FA block with 25 wt.% MSCM content achieved 28-day compressive strength of 9...
March 5, 2024: Environmental Science and Pollution Research International
https://read.qxmd.com/read/38439918/acute-genetic-damage-induced-by-ethanol-and-corticosterone-seems-to-modulate-hippocampal-astrocyte-signaling
#30
JOURNAL ARTICLE
Ana Laura Reyes-Ábalos, Magdalena Álvarez-Zabaleta, Silvia Olivera-Bravo, María Vittoria Di Tomaso
Astrocytes maintain CNS homeostasis but also critically contribute to neurological and psychiatric disorders. Such functional diversity implies an extensive signaling repertoire including extracellular vesicles (EVs) and nanotubes (NTs) that could be involved in protection or damage, as widely shown in various experimental paradigms. However, there is no information associating primary damage to the astrocyte genome, the DNA damage response (DDR), and the EV and NT repertoire. Furthermore, similar studies were not performed on hippocampal astrocytes despite their involvement in memory and learning processes, as well as in the development and maintenance of alcohol addiction...
2024: International Journal of Cell Biology
https://read.qxmd.com/read/38431400/formation-and-immunological-evaluation-of-moraxella-catarrhalis-glycoconjugates-based-on-synthetic-oligosaccharides
#31
JOURNAL ARTICLE
Taigh Anderson, Hao Jiang, Aisling Ní Cheallaigh, Dennis Bengtsson, Stefan Oscarson, Chantelle Cairns, Frank St Michael, Andrew Cox, Michelle M Kuttel
Published work has shown that glycoconjugate vaccines, based on truncated detoxified lipopolysaccharides from Moraxella catarrhalis attached through their reducing end to a carrier protein, gave good protection for all three serotypes A, B, and C in mice immunisation experiments. The (from the non-reducing end) truncated LPS structures were obtained from bacterial glycosyl transferase knock-out mutants and contained the de-esterified Lipid A, two Kdo residues and five glucose moieties. This work describes the chemical synthesis of the same outer Moraxella LPS structures, spacer-equipped and further truncated from the reducing end, i...
May 15, 2024: Carbohydrate Polymers
https://read.qxmd.com/read/38415639/enterohemorrhagic-escherichia-coli-effector-espf-triggers-oxidative-dna-lesions-in-intestinal-epithelial-cells
#32
JOURNAL ARTICLE
Yuting Fang, Muqing Fu, Xinyue Li, Bao Zhang, Chengsong Wan
Attaching/effacing (A/E) pathogens induce DNA damage and colorectal cancer by injecting effector proteins into host cells via the type III secretion system (T3SS). EspF is one of the T3SS-dependent effector proteins exclusive to A/E pathogens, which include enterohemorrhagic Escherichia coli . The role of EspF in the induction of double-strand breaks (DSBs) and the phosphorylation of the repair protein SMC1 has been demonstrated previously. However, the process of damage accumulation and DSB formation has remained enigmatic, and the damage response is not well understood...
February 28, 2024: Infection and Immunity
https://read.qxmd.com/read/38415125/comparison-of-pulmonary-artery-sarcoma-and-pulmonary-thromboembolism-according-to-clinical-and-computed-tomography-pulmonary-angiography-and-magnetic-resonance-imaging-characteristics-a-single-center-retrospective-study
#33
JOURNAL ARTICLE
Runcai Guo, Haoyu Yang, Linfeng Xi, Anqi Liu, Mei Deng, Hongyan Liu, Qian Gao, Wanmu Xie, Yanan Zhen, Zhenguo Huang, Min Liu
BACKGROUND: Pulmonary artery sarcoma (PAS) is a very rare malignancy with a poor prognosis; however, its clinical manifestations and imaging findings are often indistinguishable from pulmonary thromboembolism (PTE). We thus aimed to accurately diagnose PAS by comparing the clinical and computed tomography pulmonary angiography (CTPA) and magnetic resonance imaging (MRI) imaging characteristics of PAS and PTE. METHODS: This case-control study retrospectively enrolled 20 patients with PAS (from March 2017 to September 2022), 40 patients with central acute PTE, and 40 patients with central chronic PTE (from January 2021 to December 2022) in the China-Japan Friendship Hospital...
February 1, 2024: Quantitative Imaging in Medicine and Surgery
https://read.qxmd.com/read/38410452/illuminating-the-functions-of-the-understudied-fructosamine-3-kinase-fn3k-using-a-multi-omics-approach-reveals-new-links-to-lipid-carbon-and-co-factor-metabolic-pathways
#34
Natarajan Kannan, Safal Shrestha, Rahil Taujale, Samiksha Katiyar
Fructosamine-3-kinases (FN3Ks) are a conserved family of repair enzymes that phosphorylate reactive sugars attached to lysine residues in peptides and proteins. Although FN3Ks are present across the tree of life and share detectable sequence similarity to eukaryotic protein kinases, the biological processes regulated by these kinases are largely unknown. To address this knowledge gap, we leveraged the FN3K CRISPR Knock-Out (KO) cell line alongside an integrative multi-omics study combining transcriptomics, metabolomics, and interactomics to place these enzymes in a pathway context...
February 16, 2024: Research Square
https://read.qxmd.com/read/38410166/combining-photodynamic-therapy-and-cascade-chemotherapy-for-enhanced-tumor-cytotoxicity-the-role-of-ctt-2-p-b-nanoparticles
#35
JOURNAL ARTICLE
Rongyi Wang, Hongsen Li, Lu Han, Boao Han, Yiting Bao, Hongwei Fan, Chaoyue Sun, Ruijie Qian, Liying Ma, Jiajing Zhang
The mitochondria act as the main producers of reactive oxygen species (ROS) within cells. Elevated levels of ROS can activate the mitochondrial apoptotic pathway, leading to cell apoptosis. In this study, we devised a molecular prodrug named CTT2 P, demonstrating notable efficacy in facilitating mitochondrial apoptosis. To develop nanomedicine, we enveloped CTT2 P within bovine serum albumin (BSA), resulting in the formulation known as CTT2 P@B. The molecular prodrug CTT2 P is achieved by covalently conjugating mitochondrial targeting triphenylphosphine (PPh3 ), photosensitizer TPPOH2 , ROS-sensitive thioketal (TK), and chemotherapeutic drug camptothecin (CPT)...
2024: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/38408754/advancing-the-design-of-artificial-nano-organelles-for-targeted-cellular-detoxification-of-reactive-oxygen-species
#36
JOURNAL ARTICLE
Viviana Maffeis, Michal Skowicki, Konstantin M P Wolf, Mohamed Chami, Cora-Ann Schoenenberger, Viola Vogel, Cornelia G Palivan
Artificial organelles (AnOs) are in the spotlight as systems to supplement biochemical pathways in cells. While polymersome-based artificial organelles containing enzymes to reduce reactive oxygen species (ROS) are known, applications requiring control of their enzymatic activity and cell-targeting to promote intracellular ROS detoxification are underexplored. Here, we introduce advanced AnOs where the chemical composition of the membrane supports the insertion of pore-forming melittin, enabling molecular exchange between the AnO cavity and the environment, while the encapsulated lactoperoxidase (LPO) maintains its catalytic function...
February 26, 2024: Nano Letters
https://read.qxmd.com/read/38397256/a-systematic-review-on-assessing-assessments-unveiling-psychometric-properties-of-instruments-for-reactive-attachment-disorder-and-disinhibited-social-engagement-disorder-in-minors-under-protective-measures
#37
REVIEW
Florencia Talmón-Knuser, Miriam Soler, Francisco González-Sala, Laura Lacomba-Trejo, Paula Samper-García
BACKGROUND: Reactive attachment disorder (RAD) and disinhibited social engagement disorder (DSED) manifest in individuals facing attachment system challenges, particularly observed in minors under protective measures. The lack of standardized tools for assessing these difficulties and uncertainty about the most effective instruments from a psychometric perspective prompted this study. AIM: Using the COSMIN checklist, we systematically reviewed instruments assessing RAD, adhering to PRISMA...
January 24, 2024: Children
https://read.qxmd.com/read/38392289/mitochondrial-dysfunction-in-endothelial-progenitor-cells-unraveling-insights-from-vascular-endothelial-cells
#38
REVIEW
Azra Kulovic-Sissawo, Carolina Tocantins, Mariana S Diniz, Elisa Weiss, Andreas Steiner, Silvija Tokic, Corina T Madreiter-Sokolowski, Susana P Pereira, Ursula Hiden
Endothelial dysfunction is associated with several lifestyle-related diseases, including cardiovascular and neurodegenerative diseases, and it contributes significantly to the global health burden. Recent research indicates a link between cardiovascular risk factors (CVRFs), excessive production of reactive oxygen species (ROS), mitochondrial impairment, and endothelial dysfunction. Circulating endothelial progenitor cells (EPCs) are recruited into the vessel wall to maintain appropriate endothelial function, repair, and angiogenesis...
January 23, 2024: Biology
https://read.qxmd.com/read/38389191/patients-suffering-from-dystrophic-epidermolysis-bullosa-are-prone-to-developing-autoantibodies-against-skin-proteins-a-longitudinal-confirmational-study
#39
JOURNAL ARTICLE
J Bremer, H H Pas, G F H Diercks, H J Meijer, S M van der Molen, A M Nijenhuis, L L van Nijen-Vos, P Morandé, M J Yubero, F Palisson, I Fuentes, A M G Pasmooij
Epidermolysis bullosa (EB) is a heritable skin blistering disease caused by variants in genes coding for proteins that secure cell-cell adhesion and attachment of the epidermis to the dermis. Interestingly, several proteins involved in inherited EB are also associated with autoimmune blistering diseases (AIBD). In this study, we present a long-term follow-up of 15 patients suffering from recessive dystrophic or junctional EB. From these patients, 62 sera were analysed for the presence of autoantibodies associated with AIBD...
February 2024: Experimental Dermatology
https://read.qxmd.com/read/38382831/magnesium-lithium-thin-films-for-neurological-applications-an-in-vitro-investigation-of-glial-cytocompatibility-and-neuroinflammatory-response
#40
JOURNAL ARTICLE
Krathika Bhat, Luise Schlotterose, Lisa Hanke, Heike Helmholz, Eckhard Quandt, Kirsten Hattermann, Regine Willumeit-Römer
Lithium (Li), a widely used drug for bipolar disorder management, is associated with many side effects due to systemic exposure. The localized delivery of lithium through implants could be an approach to overcome this challenge, for which biodegradable magnesium (Mg)-based materials are a promising choice. In this study, we focus on Mg-Li thin film alloys as potential Li-releasing implants. Therefore, we investigated the in vitro short-term corrosion behavior and cytocompatibility of two alloys, Mg-1.6wt%Li and Mg-9...
February 19, 2024: Acta Biomaterialia
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