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https://www.readbyqxmd.com/read/28096239/skin-to-skin-care-in-preterm-infants-receiving-respiratory-support-does-not-lead-to-physiological-instability
#1
Laila Lorenz, Jennifer A Dawson, Hannah Jones, Susan E Jacobs, Jeanie L Cheong, Susan M Donath, Peter G Davis, C Omar F Kamlin
OBJECTIVE: Providing skin-to-skin care (SSC) to preterm infants is standard practice in many neonatal intensive care units. There are conflicting reports on the stability of oxygen saturation (SpO2) during SSC, which may create a barrier to a wider implementation of SSC to infants receiving respiratory support. Regional cerebral oxygenation (rcO2) measured using near-infrared spectroscopy can serve as a surrogate parameter for cerebral oxygen delivery and consumption. We hypothesised that rcO2 during SSC would be similar to standard care in preterm infants receiving respiratory support...
January 17, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/28068656/mechanisms-of-improved-exercise-performance-under-hyperoxia
#2
Silvia Ulrich, Elisabeth D Hasler, Séverine Müller-Mottet, Stephan Keusch, Michael Furian, Tsogyal D Latshang, Simon Schneider, Stéphanie Saxer, Konrad E Bloch
BACKGROUND: The impact of hyperoxia on exercise limitation is still incompletely understood. OBJECTIVES: We investigated to which extent breathing hyperoxia enhances the exercise performance of healthy subjects and which physiologic mechanisms are involved. METHODS: A total of 32 healthy volunteers (43 ± 15 years, 12 women) performed 4 bicycle exercise tests to exhaustion with ramp and constant-load protocols (at 75% of the maximal workload [Wmax] on FiO2 0...
January 10, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/28012013/ventilation-perfusion-ratio-and-right-to-left-shunt-in-healthy-newborn-infants
#3
Theodore Dassios, Kamal Ali, Thomas Rossor, Anne Greenough
Oxygenation impairment can be assessed non-invasively by determining the degree of right-to-left shunt and ventilation/perfusion (VA/Q) inequality. These indices have been used in sick newborn infants, but normative values have not been reported which are essential to determine the magnitude of the abnormality. We, therefore, aimed to measure the shunt and VA/Q in infants with no history of respiratory conditions and determine if there was any effect of supine or prone position and the reproducibility of the data...
December 23, 2016: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/28003557/comparing-the-effects-of-two-different-levels-of-hyperoxygenation-on-gas-exchange-during-open-endotracheal-suctioning-a-randomized-crossover-study
#4
Jacqueline Rodrigues de Freitas Vianna, Valéria Amorim Pires Di Lorenzo, Miléa Mara Lourenço da Silva Simões, Maurício Jamami
BACKGROUND: Endotracheal suctioning is required for mechanically ventilated patients to maintain a patent airway. Studies show that open endotracheal suctioning affects respiratory mechanics and gas exchange. The aim of this study was to compare the effectiveness of hyperoxygenation with FIO2 + 0.20 above baseline and hyperoxygenation with FIO2 1.0 in preventing hypoxemia, and to determine the impact of open endotracheal suctioning on the pulmonary ventilation of critical subjects receiving mechanical ventilatory support...
January 2017: Respiratory Care
https://www.readbyqxmd.com/read/27874934/effect-of-nitric-oxide-inhalation-for-the-treatment-of-neonatal-pulmonary-hypertension
#5
H-W Wu, Z-G Li, G Liu, G-Z Lu, H-Y Liang
OBJECTIVE: To investigate the effect of nitric oxide (NO) inhalation for the treatment of neonatal pulmonary hypertension. PATIENTS AND METHODS: Eighty-six patients with neonatal pulmonary hypertension who were treated for the first time Xuzhou Children's Hospital from January 2013 to January 2016 were selected and randomly divided into the observation group and control group, with 43 cases each. Patients in the control group were treated with high-frequency oscillatory ventilation, while those in the observation group were treated with high-frequency oscillatory ventilation combined with inhalational NO therapy...
November 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27851092/1456-a-comparison-of-sofa-using-spo2-fio2-ratio-to-sofa-sirs-and-qsofa-for-sepsis-mortality
#6
Faheem Guirgis, Sarah Sterling, Carmen Smotherman, Frederick Moore, Alan Jones
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27783382/short-term-effects-of-neuromuscular-blockade-on-global-and-regional-lung-mechanics-oxygenation-and-ventilation-in-pediatric-acute-hypoxemic-respiratory-failure
#7
Marlon E F Wilsterman, Pauline de Jager, Robert Blokpoel, Inez Frerichs, Sandra K Dijkstra, Marcel J I J Albers, Johannes G M Burgerhof, Dick G Markhorst, Martin C J Kneyber
BACKGROUND: Neuromuscular blockade (NMB) has been shown to improve outcome in acute respiratory distress syndrome (ARDS) in adults, challenging maintaining spontaneous breathing when there is severe lung injury. We tested in a prospective physiological study the hypothesis that continuous administration of NMB agents in mechanically ventilated children with severe acute hypoxemic respiratory failure (AHRF) improves the oxygenation index without a redistribution of tidal volume V T toward non-dependent lung zones...
December 2016: Annals of Intensive Care
https://www.readbyqxmd.com/read/27751799/performance-of-the-obstetric-early-warning-score-in-critically-ill-patients-for-the-prediction-of-maternal-death
#8
Angel Paternina-Caicedo, Jezid Miranda, Ghada Bourjeily, Andrew Levinson, Carmelo Dueñas, Camilo Bello-Muñoz, José A Rojas-Suarez
BACKGROUND: Every day, about 830 women die worldwide from preventable causes related to pregnancy and childbirth. Obstetric early warning scores have been proposed as a potential tool to reduce maternal morbidity and mortality, based on the identification of predetermined abnormal values in the vital signs or laboratory parameters, to generate a rapid and effective medical response. Several early warning scores have been developed for obstetrical patients, but the majority are the result of a clinical consensus rather than statistical analyses of clinical outcome measures (ie, maternal deaths)...
January 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27747789/hyperoxia-extends-time-to-exhaustion-during-high-intensity-intermittent-exercise-a-randomized-crossover-study-in-male-cyclists
#9
Toshiyuki Ohya, Ryo Yamanaka, Hayato Ohnuma, Masahiro Hagiwara, Yasuhiro Suzuki
BACKGROUND: Some endurance athletes exhibit exercise-induced arterial hypoxemia during high-intensity exercise. Inhalation of hyperoxic gas during exercise has been shown to counteract this exercise-associated reduction in hemoglobin oxygen saturation (SaO2), but the effects of hyperoxic gas inhalation on performance and SaO2 during high-intensity intermittent exercise remain unclear. This study investigated the effects of hyperoxic gas inhalation on performance and SaO2 during high-intensity intermittent cycling exercise...
December 2016: Sports Medicine—Open
https://www.readbyqxmd.com/read/27730283/apnoeic-oxygenation-via-high-flow-nasal-cannula-oxygen-combined-with-non-invasive-ventilation-preoxygenation-for-intubation-in-hypoxaemic-patients-in-the-intensive-care-unit-the-single-centre-blinded-randomised-controlled-optiniv-trial
#10
Samir Jaber, Marion Monnin, Mehdi Girard, Matthieu Conseil, Moussa Cisse, Julie Carr, Martin Mahul, Jean Marc Delay, Fouad Belafia, Gérald Chanques, Nicolas Molinari, Audrey De Jong
PURPOSE: High-flow nasal cannula oxygen (HFNC) has the potential to provide apnoeic oxygenation. We decided to assess in a proof-of-concept study whether the addition of HFNC to non-invasive ventilation (NIV) could reduce oxygen desaturation during intubation, compared with NIV alone for preoxygenation, in severely hypoxaemic intensive care unit (ICU) patients with respiratory failure. METHODS: We conducted a randomised, controlled, single-centre trial with assessor-blinded outcome assessment in patients admitted to the ICU...
October 11, 2016: Intensive Care Medicine
https://www.readbyqxmd.com/read/27662491/acute-physiological-responses-to-moderate-load-resistance-exercise-in-hypoxia
#11
Brendan R Scott, Katie M Slattery, Dean V Sculley, Catriona Lockhart, Ben J Dascombe
This study assessed whether hypoxia augments anabolic responses to moderate-load resistance exercise. Fourteen trained males performed moderate-load resistance exercise in normoxia (NORM; fraction of inspired oxygen [FIO2] = 21%) and moderate-level hypoxia (MH; FIO2 = 16%). Exercise comprised 3 sets of 10 repetitions of squats and deadlifts at 60% of 1-repetition maximum, with 60 s inter-set rest. Blood lactate (BLa) was quantified after each exercise, while arterial oxygen saturation (SpO2) and heart rate (HR) were assessed following each set...
September 20, 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27634820/development-and-preclinical-testing-of-an-adaptive-algorithm-for-automated-control-of-inspired-oxygen-in-the-preterm-infant
#12
Peter A Dargaville, Omid Sadeghi Fathabadi, Gemma K Plottier, Kathleen Lim, Kevin I Wheeler, Rohan Jayakar, Timothy J Gale
OBJECTIVE: To assess the performance of a novel algorithm for automated oxygen control using a simulation of oxygenation founded on in vivo data from preterm infants. METHODS: A proportional-integral-derivative (PID) control algorithm was enhanced by (i) compensation for the non-linear SpO2-PaO2 relationship, (ii) adaptation to the severity of lung dysfunction and (iii) error attenuation within the target range. Algorithm function with and without enhancements was evaluated by iterative linking with a computerised simulation of oxygenation...
January 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/27553127/dietary-nitrate-supplementation-enhances-high-intensity-running-performance-in-moderate-normobaric-hypoxia-independent-of-aerobic-fitness
#13
Oliver Michael Shannon, Lauren Duckworth, Matthew John Barlow, David Woods, Jose Lara, Mario Siervo, John Paul O'Hara
Nitrate-rich beetroot juice (BRJ) increases plasma nitrite concentrations, lowers the oxygen cost (V⋅O2) of steady-state exercise and improves exercise performance in sedentary and moderately-trained, but rarely in well-trained individuals exercising at sea-level. BRJ supplementation may be more effective in a hypoxic environment, where the reduction of nitrite into nitric oxide (NO) is potentiated, such that well-trained and less well-trained individuals may derive a similar ergogenic effect. We conducted a randomised, counterbalanced, double-blind placebo controlled trial to determine the effects of BRJ on treadmill running performance in moderate normobaric hypoxia (equivalent to 2500 m altitude) in participants with a range of aerobic fitness levels...
September 30, 2016: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/27406213/regional-hypoxic-cerebral-vasodilation-facilitated-by-diameter-changes-primarily-in-anterior-versus-posterior-circulation
#14
J Mikhail Kellawan, John W Harrell, Alejandro Roldan-Alzate, Oliver Wieben, William G Schrage
The inability to quantify cerebral blood flow and changes in macrocirculation cross-sectional area in all brain regions impedes robust insight into hypoxic cerebral blood flow control. We applied four-dimensional flow magnetic resonance imaging to quantify cerebral blood flow (ml • min(-1)) and cross-sectional area (mm(2)) simultaneously in 11 arteries. In healthy adults, blood pressure, O2 Saturation (SpO2), and end-tidal CO2 were measured at baseline and steady-state hypoxia (FiO2 = 0.11). We investigated left and right: internal carotid, vertebral, middle, anterior, posterior cerebral arteries, and basilar artery...
July 12, 2016: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/27392155/closed-loop-control-of-fio2-rapidly-identifies-need-for-rescue-ventilation-and-reduces-ards-severity-in-a-conscious-sheep-model-of-burn-and-smoke-inhalation-injury
#15
Nehemiah T Liu, Michael G Salter, Muzna N Khan, Richard D Branson, Perenlei Enkhbaatar, George C Kramer, José Salinas, Nicole R Marques, Michael P Kinsky
: Pulmonary injury can be characterized by an increased need for fraction of inspired oxygen or inspired oxygen percentage (FiO2) to maintain arterial blood saturation of oxygenation (SaO2). We tested a smart oxygenation system (SOS) that uses the activity of a closed-loop control FiO2 algorithm (CLC-FiO2) to rapidly assess acute respiratory distress syndrome (ARDS) severity so that rescue ventilation (RscVent) can be initiated earlier. After baseline data, a pulse-oximeter (noninvasive saturation of peripheral oxygenation [SpO2]) was placed...
February 2017: Shock
https://www.readbyqxmd.com/read/27387180/prone-position-in-thoracoscopic-esophagectomy-improves-postoperative-oxygenation-and-reduces-pulmonary-complications
#16
Dai Otsubo, Tetsu Nakamura, Masashi Yamamoto, Shingo Kanaji, Kiyonori Kanemitsu, Kimihiro Yamashita, Tatsuya Imanishi, Taro Oshikiri, Yasuo Sumi, Satoshi Suzuki, Daisuke Kuroda, Yoshihiro Kakeji
BACKGROUND: While thoracoscopic esophagectomy is a widely performed surgical procedure, only few studies regarding the influence of body position on changes in circulation and breathing, after the surgery, have been reported. This study aimed at evaluating the effect of body position, during surgery, on the postoperative breathing functions of the chest. METHODS: A total of 266 patients who underwent right-sided transthoracic esophagectomy for esophageal cancer from 2004 to 2012 were included in this study...
July 7, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27380961/dynamics-of-the-heart-rate-variability-and-oxygen-saturation-response-to-acute-normobaric-hypoxia-within-the-first-10%C3%A2-min-of-exposure
#17
Jakub Krejčí, Michal Botek, Andrew J McKune
Although the heart rate variability (HRV) response to hypoxia has been studied, little is known about the dynamics of HRV after hypoxia exposure. The purpose of this study was to assess the HRV and oxygen saturation (SpO2 ) responses to normobaric hypoxia (FiO2  = 9·6%) comparing 1 min segments to baseline (normoxia). Electrocardiogram and SpO2 were recorded during a 10-min hypoxia exposure in 29 healthy male subjects aged 26·0 ± 4·9 years. Baseline HRV values were obtained from a 5-min recording period prior to hypoxia...
July 6, 2016: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/27330683/circulating-insulin-like-growth-factor-binding-protein-3-as-prognostic-biomarker-in-liver-cirrhosis
#18
Carina Gabriela Correa, Bruno da Silveira Colombo, Marcelo Fernando Ronsoni, Pedro Eduardo Soares E Silva, Leonardo Fayad, Telma Erotides Silva, Letícia Muraro Wildner, Maria Luiza Bazzo, Esther Buzaglo Dantas-Correa, Janaína Luz Narciso-Schiavon, Leonardo de Lucca Schiavon
AIM: To investigate the prognostic significance of insulin-like growth factor-binding protein 3 (IGFBP-3) in patients with cirrhosis. METHODS: Prospective study that included two cohorts: outpatients with stable cirrhosis (n = 138) and patients hospitalized for acute decompensation (n = 189). Development of complications, mortality or liver transplantation was assessed by periodical phone calls and during outpatient visits. The cohort of stable cirrhosis also underwent clinical and laboratory evaluation yearly (2013 and 2014) in predefined study visits...
June 18, 2016: World Journal of Hepatology
https://www.readbyqxmd.com/read/27289463/design-and-construction-of-a-microcontroller-based-ventilator-synchronized-with-pulse-oximeter
#19
Adem Gölcük, Hakan Işık, İnan Güler
This study aims to introduce a novel device with which mechanical ventilator and pulse oximeter work in synchronization. Serial communication technique was used to enable communication between the pulse oximeter and the ventilator. The SpO2 value and the pulse rate read on the pulse oximeter were transmitted to the mechanical ventilator through transmitter (Tx) and receiver (Rx) lines. The fuzzy-logic-based software developed for the mechanical ventilator interprets these values and calculates the percentage of oxygen (FiO2) and Positive End-Expiratory Pressure (PEEP) to be delivered to the patient...
July 2016: Journal of Medical Systems
https://www.readbyqxmd.com/read/27274092/high-flow-nasal-cannula-versus-bag-valve-mask-for-preoxygenation-before-intubation-in-subjects-with-hypoxemic-respiratory-failure
#20
Marcel Simon, Christian Wachs, Stephan Braune, Geraldine de Heer, Daniel Frings, Stefan Kluge
BACKGROUND: Critically ill patients with respiratory failure undergoing intubation have an increased risk of hypoxemia-related complications. Delivering oxygen via a high-flow nasal cannula (HFNC) has theoretical advantages and is increasingly used. This study was conducted to compare HFNC with bag-valve-mask (BVM) for preoxygenation and to assess oxygenation during intubation in subjects with hypoxemic respiratory failure. METHODS: This study was a randomized controlled trial including 40 critically ill subjects with hypoxemic respiratory failure who received either HFNC or BVM for preoxygenation before intubation in the ICU...
September 2016: Respiratory Care
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