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Antoine Thierry, Yannick Le Meur, Laure Ecotière, Ramzi Abou-Ayache, Isabelle Etienne, Charlotte Laurent, Vincent Vuiblet, Charlotte Colosio, Nicolas Bouvier, Jean-Claude Aldigier, Jean-Philippe Rerolle, Vincent Javaugue, Elise Gand, Frank Bridoux, Marie Essig, Bruno Hurault de Ligny, Guy Touchard
Long-term outcomes in renal transplant recipients withdrawn from steroid and submitted to further minimization of immunosuppressive regimen after 1 year are lacking. In this multicenter study, 204 low immunological risk kidney transplant recipients were randomized 14.2 ± 3.7 months post-transplantation to receive either cyclosporine A (CsA) + azathioprine (AZA; n = 53), CsA + mycophenolate mofetil (MMF; n = 53), or CsA monotherapy (n = 98). At 3 years postrandomization, the occurrence of biopsy for graft dysfunction was similar in bitherapy and monotherapy groups (21/106 vs...
January 2016: Transplant International: Official Journal of the European Society for Organ Transplantation
R Abou-Ayache, M Büchler, P Le Pogamp, P-F Westeel, Y Le Meur, I Etienne, B Hurault de Ligny, O Toupance, S Caillard, G Sinnasse-Raymond, G Touchard
Cytomegalovirus (CMV) infections posttransplant may increase the risk of acute rejection, graft failure, patient death, opportunistic infections, malignancy, diabetes, and cardiovascular complications. ECTAZ, a multicenter, randomized trial compared safety and efficacy at 12 months (M12) of two doses daclizumab (54 patients, group D) with thymoglobulin (55 patients, group T), plus cyclosporine (CsA), mycophenolate mofetil and steroids in first cadaveric kidney transplant patients. D+/R- patients received oral ganciclovir prophylaxis for 90 days...
September 2011: Transplantation Proceedings
F Leroy, F Bridoux, R Abou-Ayache, S Belmouaz, E Desport, A Thierry, M Bauwens, G Touchard
Acute bilateral renal cortical necrosis is a rare cause of renal failure frequently induced by disseminated intravascular coagulation (Dic) following obstetrical complications, sepsis and drugs. We describe a case of Dic with bilateral cortical necrosis after ingestion of only one tablet of quinine. A 41-year-old woman was admitted for severe abdominal pain, melaena, fever and anuria two hours after quinine tablet intake for nocturnal leg cramps. Her medical history included angioneurotic edema caused by chloroquine for malaria prevention...
June 2008: Néphrologie & Thérapeutique
Ramzi Abou-Ayache, Mathias Büchler, Patrick Lepogamp, Pierre-François Westeel, Yannick Le Meur, Isabelle Etienne, Thierry Lobbedez, Olivier Toupance, Sophie Caillard, Jean-Michel Goujon, Loïc Bergougnoux, Guy Touchard
BACKGROUND: Cytomegalovirus (CMV) infection is a major complication after renal transplantation and is involved in graft rejection. The anti-interleukin-2-receptor antibody daclizumab reduces the incidence of acute rejection without increasing the incidence of CMV infection. METHODS: This multicentre, randomized trial compared safety and efficacy, at 1 year, of two doses of daclizumab (54 patients, group D) with thymoglobulin (55 patients, group T) plus delayed cyclosporine (CsA), MMF (mycophenolate mofetil) and steroids in first cadaver kidney transplant patients...
June 2008: Nephrology, Dialysis, Transplantation
R Abou Ayache, A Thierry, F Bridoux, M Bauwens, M Belmouaz, E Desport, G Touchard
The incidence of skin cancer after organ transplantation is mainly related to type, level, and duration of immunosuppression. The immunosuppressive minimization strategy reduces skin malignancies, but no data are available concerning long-term calcineurin inhibitor (CNI) monotherapy compared with bi- or tritherapy. We studied the benefits of long-term CNI monotherapy (>6 years of exposure) with regard to the incidence of squamous cell carcinomas (SCC) and basal cell carcinomas (BCC) compared with bi- or tritherapy, among first renal allograft adult recipients who were more than 6 years posttransplantation...
October 2007: Transplantation Proceedings
Simohamed Belmouaz, Anne Sechet, Béatrice Fernandez, Ramzi Abou Ayache, Estelle Desport, Marc Bauwens, Jean-Michel Goujon, Jean-Marc Gombert, Frank Bridoux, Guy Touchard
No abstract text is available yet for this article.
July 2007: Nephrology, Dialysis, Transplantation
S Belmouaz, E Desport, R Abou Ayache, A Thierry, A Mignot, M Bauwens, J M Goujon, F Bridoux, G Touchard
Fluindione is a vitamin K antagonist that is commonly prescribed for the treatment of cardiovascular disease and venous thromboembolism in France. Bleeding is the most common side effect of fluindione, whereas hypersensitivity reactions are rare. We describe here a patient with acute immuno-allergic interstitial nephritis caused by fluindione. Initial symptoms included fever, eosinophilia, low albuminuria, microscopic hematuria, eosinophiluria and acute renal failure. Kidney biopsy showed severe interstitial nephritis with interstitial edema, inflammatory infiltrates and tubulorrhexis...
December 2006: Clinical Nephrology
F Leroy, A Sechet, R Abou Ayache, A Thierry, S Belmouaz, E Desport, M Bauwens, F Bridoux, G Touchard
Cytomegalovirus (CMV) seronegative renal allograft recipients (R-), particularly those with a graft from a CMV-seropositive donor (D+), are at high risk for primary CMV infection. CMV resistance to antiviral oral therapy is an emerging problem in renal transplantation, prompting development of new prophylactic strategies. We retrospectively studied the 1-year posttransplantation incidence of CMV infection in high-risk renal transplant recipients, in whom polyvalent intravenous immunoglobulins (IVIg) were used as prophylaxis...
September 2006: Transplantation Proceedings
R Abou Ayache, F Bridoux, F Pessione, A Thierry, M Belmouaz, F Leroy, E Desport, M Bauwens, G Touchard
Recent studies have clearly demonstrated that preemptive renal transplantation is associated with better graft and patient survival. It improves the quality of life and is a cost-effective option compared to conventional transplantation. We report our experience with this concept and review the literature. We retrospectively analyzed all adult kidney transplantations performed in our center between March 1986 and May 2004: among 463 renal transplantations 44 were preemptive (9.5%). Mean follow-up was 45.7 +/- 6 months in preemptive versus 62...
July 2005: Transplantation Proceedings
Frank Bridoux, Christophe Sirac, Valérie Hugue, Catherine Decourt, Antoine Thierry, Nathalie Quellard, Ramzi Abou-Ayache, Jean-Michel Goujon, Michel Cogné, Guy Touchard
Fanconi's syndrome (FS) is a disorder of sodium-dependent proximal tubule reabsorption, which may complicate plasma cell disorders producing a free monoclonal light chain (LC). FS often occurs in the setting of smoldering myeloma and features cytoplasmic crystalline inclusions of monoclonal kappa LC in proximal tubular cells and malignant plasma cells. Although the clinical and pathological presentation may vary, including lack of crystal formation, monoclonal kappa LCs that underlie FS show a striking genetic and biochemical homogeneity: they almost always belong to the Vkappa1 subgroup of variability and originate from 2 germline genes, O2/O12 or O8/O18...
April 2005: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Estelle Desport, Frank Bridoux, Ramzi Abou Ayache, Antoine Thierry, Simohamed Belmouaz, Jacques Irani, Jean Michel Goujon, Marc Bauwens, Guy Touchard
No abstract text is available yet for this article.
April 2005: Nephrology, Dialysis, Transplantation
A Thierry, F Bridoux, H Goodman, S Belmouaz, R Abou Ayache, E Desport, A Jaccard, G Touchard
AL amyloidosis is a rare disorder characterised by tissue deposition of a fibrillary proteinaceous material, formed from monoclonal immunoglobulin light (or exceptionally heavy) chains. Although it may complicate multiple myeloma or B-cell lymphomas, AL amyloidosis is often associated with a low burden of clonal plasma cells ("primitive" AL amyloidosis). The mechanisms involved in the formation of AL amyloid deposits remain unclear, but are probably related to structural peculiarities of monoclonal immunoglobulin light chains...
2004: Néphrologie
F Bridoux, X Kyndt, R Abou-Ayache, B Mougenot, S Baillet, M Bauwens, V Lemaitre, J M Goujon, G Touchard, P Vanhille
Tubulointerstitial nephritis is the most common renal complication in primary Sjögren's syndrome (SS). It is usually associated with symptoms of distal tubular dysfunction, type I (distal) renal tubular acidosis (RTA) and nephrogenic diabetes insipidus. Proximal tubular abnormalities are considered to be less frequent, and Fanconi's syndrome has been only exceptionally reported in patients with SS. We describe 2 patients with primary SS, characterized by xerostomia, dry eyes, extensive lymphocytic infiltrate on salivary gland biopsy, positive tests for anti-SSA/SSB antibodies and/or antinuclear antibodies, who presented in renal failure with proteinuria, microscopic hematuria and type I RTA...
June 2004: Clinical Nephrology
Frank Bridoux, François Provôt, Ramzi Abou Ayache, Jean-Michel Goujon, Guy Touchard
UNLABELLED: CHARACTERISTICS OF THE RENAL DAMAGE: Type I cryoglobulinemia, composed of a single monoclonal immunoglobulin, may be responsible for a glomerulopathy with clinical presentation and histological characteristics close to those of mixed cryoglobulinemia. CONTEXT: Type I cryoglobulins complicate a malignant haematological disease, chronic lymphoid leukaemia or non-Hodgkin's malignant lymphoma in 60% of cases. EVOLUTION: Treatment with corticosteroids and immunosuppressors or antimitotics often leads to the parallel stabilisation or remission of the renal manifestations and the haematological disease ...
March 29, 2003: La Presse Médicale
Frank Bridoux, François Provôt, Ramzi Abou Ayache, Jean-Michel Goujon, Guy Touchard
UNLABELLED: THE CONTEXT: Type II cryoglobulinemia, composed of a monoclonal IgM rheumatoid factor directed against polyclonal IgG, is associated in most cases with chronic hepatitis C viral infection. THE CHARACTERISTICS OF RENAL DAMAGE: Frequent, the renal damage usually occurs after the onset of various systemic manifestations and is expressed by moderate renal failure, microscopic haematuria, proteinuria lower than 3 g/d and hypertension difficult to control. More severe aspects are possible such as acute nephrotic or nephritic syndromes, or even multi-organ failure with anuria...
March 29, 2003: La Presse Médicale
Frank Bridoux, François Provôt, Ramzi Abou Ayache, Jean-Michel Goujon, Guy Touchard
No abstract text is available yet for this article.
March 29, 2003: La Presse Médicale
A Séchet, F Bridoux, M Bauwens, R Abou Ayache, S Belmouaz, G Touchard
No abstract text is available yet for this article.
May 2002: Transplantation Proceedings
C Verove, F Bridoux, R Abou-Ayache, M Bauwens, J Drouineau, G Touchard
No abstract text is available yet for this article.
June 1999: Nephrology, Dialysis, Transplantation
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