Michael Ej Lean, Wilma S Leslie, Alison C Barnes, Naomi Brosnahan, George Thom, Louise McCombie, Tara Kelly, Keaton Irvine, Carl Peters, Sviatlana Zhyzhneuskaya, Kieren G Hollingsworth, Ashley J Adamson, Falko F Sniehotta, John C Mathers, Yvonne McIlvenna, Paul Welsh, Alex McConnachie, Alasdair McIntosh, Naveed Sattar, Roy Taylor
BACKGROUND: In DiRECT, a randomised controlled effectiveness trial, weight management intervention after 2 years resulted in mean weight loss of 7·6 kg, with 36% of participants in remission of type 2 diabetes. Of 36 in the intervention group who maintained over 10 kg weight loss at 2 years, 29 (81%) were in remission. Continued low-intensity dietary support was then offered up to 5 years from baseline to intervention participants, aiming to maintain weight loss and gain clinical benefits...
February 26, 2024: Lancet Diabetes & Endocrinology