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epilepsy; seizures

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https://www.readbyqxmd.com/read/28944447/serotonin-reuptake-inhibitors-and-mortality-in-epilepsy-a-linked-primary-care-cohort-study
#1
Colin B Josephson, Arturo Gonzalez-Izquierdo, Spiros Denaxas, Natalie K Fitzpatrick, Tolulope T Sajobi, Jordan D T Engbers, Scott Patten, Nathalie Jette, Samuel Wiebe
OBJECTIVE: Preliminary evidence suggests that serotonin reuptake inhibitor (SRI) use may increase postictal respiratory drive and prevent death. We sought to determine whether SRIs are associated with improved all-cause and possible seizure-specific mortality in patients with epilepsy. METHODS: Patients with epilepsy and a random 10:1 sample without epilepsy were extracted from The ClinicAl research using LInked Bespoke studies and Electronic health Records (CALIBER) resource...
September 24, 2017: Epilepsia
https://www.readbyqxmd.com/read/28944233/protein-structure-and-phenotypic-analysis-of-pathogenic-and-population-missense-variants-in-stxbp1
#2
Mohnish Suri, Jochem M G Evers, Roman A Laskowski, Sinead O'Brien, Kate Baker, Jill Clayton-Smith, Tabib Dabir, Dragana Josifova, Shelagh Joss, Bronwyn Kerr, Alison Kraus, Meriel McEntagart, Jenny Morton, Audrey Smith, Miranda Splitt, Janet M Thornton, Caroline F Wright
BACKGROUND: Syntaxin-binding protein 1, encoded by STXBP1, is highly expressed in the brain and involved in fusing synaptic vesicles with the plasma membrane. Studies have shown that pathogenic loss-of-function variants in this gene result in various types of epilepsies, mostly beginning early in life. We were interested to model pathogenic missense variants on the protein structure to investigate the mechanism of pathogenicity and genotype-phenotype correlations. METHODS: We report 11 patients with pathogenic de novo mutations in STXBP1 identified in the first 4293 trios of the Deciphering Developmental Disorder (DDD) study, including six missense variants...
September 2017: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/28943291/antidepressant-anticonvulsant-and-antinociceptive-effects-of-3-methoxy-6-methylflavone-and-3-hydroxy-6-methylflavone-may-involve-gabaergic-mechanisms
#3
Nasiara Karim, Imran Khan, Naveed Ahmad, Muhammad Naveed Umar, Navnath Gavande
BACKGROUND: GABAA receptors have been implicated in the pathophysiology of depression, epilepsy and pain disorders. The purpose of this study was to investigate two novel synthetic flavones, 3'-methoxy-6-methylflavone (3'-MeO6MF) and 3'-hydroxy-6-methylflavone (3'-OH6MF), for their effect on GABAA receptors and subsequently investigate their antidepressant, anticonvulsant and antinociceptive effects. METHODS: Recombinant GABAA receptor subunits were expressed in Xenopus oocytes and a two electrode voltage clamp technique was used for electrophysiological studies...
March 10, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28942967/de-novo-mutations-in-ppp3ca-cause-severe-neurodevelopmental-disease-with-seizures
#4
Candace T Myers, Nicholas Stong, Emily I Mountier, Katherine L Helbig, Saskia Freytag, Joseph E Sullivan, Bruria Ben Zeev, Andreea Nissenkorn, Michal Tzadok, Gali Heimer, Deepali N Shinde, Arezoo Rezazadeh, Brigid M Regan, Karen L Oliver, Michelle E Ernst, Natalie C Lippa, Maureen S Mulhern, Zhong Ren, Annapurna Poduri, Danielle M Andrade, Lynne M Bird, Melanie Bahlo, Samuel F Berkovic, Daniel H Lowenstein, Ingrid E Scheffer, Lynette G Sadleir, David B Goldstein, Heather C Mefford, Erin L Heinzen
Exome sequencing has readily enabled the discovery of the genetic mutations responsible for a wide range of diseases. This success has been particularly remarkable in the severe epilepsies and other neurodevelopmental diseases for which rare, often de novo, mutations play a significant role in disease risk. Despite significant progress, the high genetic heterogeneity of these disorders often requires large sample sizes to identify a critical mass of individuals with disease-causing mutations in a single gene...
September 15, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/28942448/antagomirs-targeting-microrna-134-increase-limk1-levels-after-experimental-seizures-in-vitro-and-in-vivo
#5
Jiahang Sun, Xiaoying Gao, Dawei Meng, Yang Xu, Xichun Wang, Xin Gu, Mian Guo, Xiaodong Shao, Hongwen Yan, Chuanlu Jiang, Yongri Zheng
BACKGROUND: MiR-134 is enriched in dendrites of hippocampal neurons and plays crucial roles in the progress of epilepsy. The present study aims to investigate the effects of antagomirs targeting miroRNA-134 (Ant-134) on limk1 expression and the binding of miR-134 and limk1 in experimental seizure. METHODS: Status epilepticus (SE) rat model was established by lithium chloride-pilocarpine injection and was treated with Ant-134 by intracerebroventricular injection...
September 22, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28941835/pharmacoresistance-with-newer-anti-epileptic-drugs-in-mesial-temporal-lobe-epilepsy-with-hippocampal-sclerosis
#6
Michael S Pohlen, Jingxiao Jin, Ronnie S Tobias, Atul Maheshwari
This study aims to evaluate the overall prognosis, prognostic factors, and efficacy of treatment in patients with mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) who have access to third generation anti-epileptic drugs but not to epilepsy surgery. Eighty-five MTLE-HS patients were retrospectively placed into a seizure-free (seizure-free for >1year) or drug-resistant group, and the two groups were compared on the basis of age, sex, age at onset of seizures, duration of epilepsy, side of lesion, handedness, EEG findings, history of CNS infection, history of febrile convulsions, history of head trauma, history of cognitive impairment, family history of seizures, number of current anti-epileptic drugs (AEDs), total number of AED trials, and presence of individual AEDs...
September 19, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28941623/post-licensure-safety-surveillance-study-of-routine-use-of-quadrivalent-meningococcal-diphtheria-toxoid-conjugate-vaccine
#7
J Hansen, L Zhang, N P Klein, C A Robertson, M D Decker, D P Greenberg, E Bassily, R Baxter
BACKGROUND: Menactra® vaccine (MenACWY-D) was licensed in the United States in 2005 for persons 11-55years of age. The aim of this study was to assess the safety of MenACWY-D administered as part of routine clinical care to patients at Kaiser Permanente Northern California (KPNC). METHODS: This was an observational, retrospective study that included all KPNC members who received MenACWY-D during the study period. We monitored all vaccine recipients for non-elective hospitalizations, emergency department visits, and selected outcomes captured in the clinic setting (Bell's palsy, seizures, neuritis, Guillain-Barré syndrome, encephalopathy, encephalitis, epilepsy, transverse myelitis, multiple sclerosis, hypersensitivity reactions, idiopathic thrombocytopenic purpura, diabetes, arthritis, hemolytic anemia, collagen-vascular disease) through 6months after vaccination...
September 20, 2017: Vaccine
https://www.readbyqxmd.com/read/28941295/the-roles-of-interleukin-1-and-rhoa-signaling-pathway-in-rat-epilepsy-model-treated-with-low-frequency-electrical-stimulation
#8
Ai-Hua Liu, Ya-Ting Wu, Li-Ping Li, Yu-Ping Wang
This study aims to explore the correlation between interleukin-1 (IL-1) and epilepsy in rats when treated with low-frequency electrical stimulation via the RhoA/ROCK signaling pathway. Twenty-four SD rats were elected for this study, among which six rats were assigned as the normal group. And 16 rat models with epilepsy were successfully established and assigned into the model group, the ES group and the ES + IL-8 group, with each group comprising of six rats. The seizure frequency and duration was recorded...
September 23, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28940083/efficacy-and-safety-of-antiepileptic-drugs-for-refractory-partial-onset-epilepsy-a-network-meta-analysis
#9
REVIEW
Qingting Hu, Fang Zhang, Wenhui Teng, Fangfang Hao, Jing Zhang, Mingxiao Yin, Naidong Wang
The optimal combination of antiepileptic drugs (AEDs) for the treatment of refractory partial-onset epilepsy is a perpetual point of debate. While several network meta-analyses (NMAs) have been published, conclusions remain controversial, especially since newer AEDs have been introduced. In our review, we included the newer AEDs to evaluate the comparative efficacy and safety of AEDs for the treatment of refractory partial-onset epilepsy. We searched PubMed, Embase, and the Cochrane Central Register of Controlled Trials (Cochrane Library 2017, Issue 1) from their inception to February 18, 2017...
September 22, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28939854/a-combination-of-nmda-and-ampa-receptor-antagonists-retards-granule-cell-dispersion-and-epileptogenesis-in-a-model-of-acquired-epilepsy
#10
Alina Schidlitzki, Friederike Twele, Rebecca Klee, Inken Waltl, Kerstin Römermann, Sonja Bröer, Sebastian Meller, Ingo Gerhauser, Vladan Rankovic, Dandan Li, Claudia Brandt, Marion Bankstahl, Kathrin Töllner, Wolfgang Löscher
Epilepsy may arise following acute brain insults, but no treatments exist that prevent epilepsy in patients at risk. Here we examined whether a combination of two glutamate receptor antagonists, NBQX and ifenprodil, acting at different receptor subtypes, exerts antiepileptogenic effects in the intrahippocampal kainate mouse model of epilepsy. These drugs were administered over 5 days following kainate. Spontaneous seizures were recorded by video/EEG at different intervals up to 3 months. Initial trials showed that drug treatment during the latent period led to higher mortality than treatment after onset of epilepsy, and further, that combined therapy with both drugs caused higher mortality at doses that appear safe when used singly...
September 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28939512/piperine-loaded-chitosan-stpp-nanoparticles-reduce-neuronal-loss-and-astrocytes-activation-in-chemical-kindling-model-of-epilepsy
#11
Diana Anissian, Maryam Ghasemi-Kasman, Mohsen Khalili-Fomeshi, Atefeh Akbari, Mona Hashemian, Sohrab Kazemi, Aliakbar Moghadamnia
Recent evidence suggests that encapsulation of hydrophobic drugs in biodegradable polymers opens a new horizon in nanomedicine filed. Piperine, a main alkaloid form of black pepper possesses potent anticonvulsant activity. However, the low water solubility of piperine has limited its clinical application. In this study, piperine was loaded on chitosan-sodium tripolyphosphate nanoparticles (CS-STPP NPs) and the effect of piperine NPs on seizures behavior and astrocytes activation was assessed in pentylentetrazol (PTZ)-induced kindling model...
September 19, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28939289/radiosurgery-for-epilepsy-systematic-review-and-international-stereotactic-radiosurgery-society-isrs-practice-guideline
#12
REVIEW
Aileen McGonigal, Arjun Sahgal, Antonio De Salles, Motohiro Hayashi, Marc Levivier, Lijun Ma, Roberto Martinez, Ian Paddick, Samuel Ryu, Ben J Slotman, Jean Régis
BACKGROUND: While there are many reports of radiosurgery for treatment of drug-resistant epilepsy, a literature review is lacking. OBJECTIVE: The aim of this systematic review is to summarize current literature on the use of stereotactic radiosurgery (RS) for treatment of epilepsy. METHODS: Literature search was performed using various combinations of the search terms "radiosurgery", "stereotactic radiosurgery", "Gamma Knife", "epilepsy" and "seizure", from 1990 until October 2015...
September 19, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28938694/preclinical-evidence-of-ghrelin-as-a-therapeutic-target-in-epilepsy
#13
REVIEW
Tongtong Ge, Wei Yang, Jie Fan, Bingjin Li
Ghrelin, an orexigenic peptide synthesized by endocrine cells of the gastric mucosa, plays a major role in inhibiting seizures. However, the underlying mechanism of ghrelin's anticonvulsant action is still unclear. Nowadays, there are considerable evidences showing that ghrelin is implicated in various neurophysiological processes, including learning and memory, neuroprotection, neurogenesis, and inflammatory effects. In this review, we will summarize the effects of ghrelin on epilepsy. It may provide a comprehensive picture of the role of ghrelin in epilepsy...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28936771/functional-investigation-of-a-grin2a-variant-associated-with-rolandic-epilepsy
#14
Xing-Xing Xu, Xiao-Rong Liu, Cui-Ying Fan, Jin-Xing Lai, Yi-Wu Shi, Wei Yang, Tao Su, Jun-Yu Xu, Jian-Hong Luo, Wei-Ping Liao
N-methyl-D-aspartate receptors (NMDARs), a subtype of glutamate-gated ion channels, play a central role in epileptogenesis. Recent studies have identified an increasing number of GRIN2A (a gene encoding the NMDAR GluN2A subunit) mutations in patients with epilepsy. Phenotypes of GRIN2A mutations include epilepsy-aphasia disorders and other epileptic encephalopathies, which pose challenges in clinical treatment. Here we identified a heterozygous GRIN2A mutation (c.1341T>A, p.N447K) from a boy with Rolandic epilepsy by whole-exome sequencing...
September 21, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/28936065/high-frequency-of-depressive-symptoms-among-adults-with-epilepsy-results-from-a-hospital-based-study
#15
Syam C Chandrasekharan, Vikas Menon, Vaibhav Wadwekar, Pradeep Pankajakshan Nair
CONTEXT: Assessment of comorbid burden of depression and associated factors among adult people living with epilepsy (PWE) has the potential to inform clinical evaluation and management to improve outcomes. AIM: The aim of this study is to determine frequency of depressive symptoms and factors associated with it among PWE attending a tertiary care hospital. SETTING AND DESIGN: This was a cross-sectional observational study conducted in the outpatient clinic of a tertiary care center...
August 2017: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/28934624/gamification-of-medication-adherence-in-epilepsy
#16
REVIEW
Mohammad Izzat Abdul Rahim, Rhys Huw Thomas
Adherence to medication regimens is a crucial factor in seizure-freedom and well-being for people with epilepsy. In contrast, taking medication inconsistently increases the risk of not only seizures and their adverse effects, but drug side-effects and unnecessary modifications to treatment plans. Epilepsy is prevalent across all age groups and we have been slow to utilise both the technologies and psychologies derived from computer gaming. Gaming has broken through to the mainstream and is no longer the preserve of younger males, mirroring the adoption of smart-phones...
September 14, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28934527/proton-mr-spectroscopy-in-patients-with-sleep-related-hypermotor-epilepsy-she-evidence-of-altered-cingulate-cortex-metabolism
#17
Ilaria Naldi, Francesca Bisulli, Claudia Testa, Giovanni Rizzo, Lorenzo Ferri, Laura L Gramegna, Laura Licchetta, Raffaele Lodi, Caterina Tonon, Paolo Tinuper
Study Objectives: To identify structural and/or metabolic alterations in patients with sleep-related hypermotor epilepsy (SHE) using magnetic resonance imaging (MRI) and proton MR spectroscopy (1H-MRS). Methods: Nineteen SHE patients (seven males; 34.7 ± 9.7 years, mean age ± standard deviation) and 17 matched healthy volunteers (seven males; 34.0 ± 8.9 years) were included in the study. In all patients, the diagnosis of SHE was confirmed by video-polysomnographic recording of seizures...
September 1, 2017: Sleep
https://www.readbyqxmd.com/read/28931473/psychiatric-and-behavioral-side-effects-of-antiepileptic-drugs-in-adults-with-epilepsy
#18
Baibing Chen, Hyunmi Choi, Lawrence J Hirsch, Austen Katz, Alexander Legge, Richard Buchsbaum, Kamil Detyniecki
PURPOSE: Psychiatric and behavioral side effects (PBSEs) are common, undesirable effects associated with antiepileptic drug (AED) use. The objective of the study was to compare the PBSE profiles of older and newer AEDs in a large specialty practice-based sample of patients diagnosed with epilepsy. METHODS: As part of the Columbia and Yale AED Database Project, we reviewed patient records including demographics, medical history, AED use, and side effects for 4085 adult patients (age: 18 years) newly started on an AED regimen...
September 17, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28931250/minimally-invasive-transpalpebral-endoscopic-assisted-amygdalohippocampectomy
#19
Mauricio Mandel, Eberval Gadelha Figueiredo, Suzana Abramovicz Mandel, Rafael Tutihashi, Manoel Jacobsen Teixeira
BACKGROUND: Although anterior temporal lobectomy may be a definitive surgical treatment for epileptic patients with mesial temporal sclerosis, it often results in verbal, visual, and cognitive dysfunction. Studies have consistently reported the advantages of selective procedures compared with a standard anterior temporal lobectomy, mainly in terms of neuropsychological outcomes. OBJECTIVE: To describe a new technique to perform a selective amygdalohippocampectomy (SAH) through a transpalpebral approach with endoscopic assistance...
February 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28930766/palinacousis-palinacousis-seven-new-cases
#20
Madeline C Fields, Lara V Marcuse, Ji-Yeoun Yoo, Saadi Ghatan
PURPOSE: Palinacousis is an auditory illusion of sound persisting or repeating after the cessation of an auditory stimulation. Up until now, approximately 32 cases have been reported. The purpose of this study is to describe an additional seven cases of palinacousis and review our understanding of audition and palinacousis. METHODS: Patients seen in the epilepsy clinic or admitted to the Epilepsy Monitoring Unit (EMU) at The Mount Sinai Hospital who experienced palinacousis were included...
September 15, 2017: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
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