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Zinc deficiency

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https://www.readbyqxmd.com/read/28811488/deregulation-of-zpr1-causes-respiratory-failure-in-spinal-muscular-atrophy
#1
Naresh K Genabai, Annapoorna Kannan, Saif Ahmad, Xiaoting Jiang, Kanchan Bhatia, Laxman Gangwani
Spinal muscular atrophy (SMA) is caused by the low levels of survival motor neuron (SMN) protein and is characterized by motor neuron degeneration and muscle atrophy. Respiratory failure causes death in SMA but the underlying molecular mechanism is unknown. The zinc finger protein ZPR1 interacts with SMN. ZPR1 is down regulated in SMA patients. We report that ZPR1 functions downstream of SMN to regulate HoxA5 levels in phrenic motor neurons that control respiration. Spatiotemporal inactivation of Zpr1 gene in motor neurons down-regulates HoxA5 and causes defects in the function of phrenic motor neurons that results in respiratory failure and perinatal lethality in mice...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28801722/effect-of-disturbances-of-zinc-and-copper-on-the-physical-and-mental-health-status-of-patients-with-alcohol-dependence
#2
M Ordak, E Bulska, K Jablonka-Salach, A Luciuk, M Maj-Żurawska, H Matsumoto, T Nasierowski, M Wojnar, J Matras, E Muszynska, M Bujalska-Zadrozny
The concentrations of copper and zinc in the tissues of alcohol-addicted people can significantly correlate with the variables describing their mental state. Studies on the homeostasis of zinc in alcohol-dependent patients have often been characterized by low hypozincemia detection. This may be caused by a low content of zinc in blood serum (1%) compared to the average zinc level in the body. Unfortunately, most authors have identified extracellular zinc in their studies. In the available literature, data on the level of copper in patients suffering from alcohol dependence are inconsistent...
August 12, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28799141/trace-element-and-vitamin-concentrations-in-paediatric-dialysis-patients
#3
Triona Joyce, Frances Court Brown, Dean Wallace, Christopher J D Reid, Manish D Sinha
BACKGROUND: There are few recent data regarding blood micronutrient concentrations and supplementation in children on maintenance dialysis. We investigated micronutrient concentrations following dialysis commencement. METHODS: Retrospective review, including all children on maintenance dialysis (peritoneal dialysis, PD; intermittent haemodialysis, IHD), for nutritional blood concentrations measured over the first 12 months. Patients received pyridoxine and Dialyvit® daily with planned 3-monthly micronutrient concentration monitoring including selenium, manganese, copper, zinc, folate and vitamins A, D, B12 and E...
August 10, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28797054/large-scale-wheat-flour-folic-acid-fortification-program-increases-plasma-folate-levels-among-women-of-reproductive-age-in-urban-tanzania
#4
Ramadhani A Noor, Ajibola I Abioye, Nzovu Ulenga, Salum Msham, George Kaishozi, Nilupa S Gunaratna, Ramadhani Mwiru, Erin Smith, Christina Nyhus Dhillon, Donna Spiegelman, Wafaie Fawzi
There is widespread vitamin and mineral deficiency problem in Tanzania with known deficiencies of at least vitamin A, iron, folate and zinc, resulting in lasting negative consequences especially on maternal health, cognitive development and thus the nation's economic potential. Folate deficiency is associated with significant adverse health effects among women of reproductive age, including a higher risk of neural tube defects. Several countries, including Tanzania, have implemented mandatory fortification of wheat and maize flour but evidence on the effectiveness of these programs in developing countries remains limited...
2017: PloS One
https://www.readbyqxmd.com/read/28793230/role-of-silver-doping-on-the-defects-related-photoluminescence-and-antibacterial-behaviour-of-zinc-oxide-nanoparticles
#5
Vinod Kumar, Jai Prakash, Jitendra Pal Singh, Keun Hwa Chae, C Swart, O M Ntwaeaborwa, H C Swart, Viresh Dutta
The Ag doped ZnO (ZnO:Ag) NPs with a hexagonal wurtzite structure were synthesized by a solution combustion method. X-ray absorption near edge structure (XANES) and X-ray photoelectron spectroscopy (XPS) were used to study the defects, local electronic and atomic structures before and after Ag doping. XPS and XANES studies confirmed the deficiency of concentration of defects in ZnO after Ag doping. The photoluminescence study showed the deep level emission in the orange-red region in addition to the band to band emission...
July 29, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28790120/zinc-containing-dental-fixative-causing-copper-deficiency-myelopathy
#6
Liam Stuart Carroll, Azmil H Abdul-Rahim, Rosanne Murray
A 62-year-old male, previously well, was referred to neurology clinic following 6 months history of worsening lower limbs instability, paraesthesia, pain and weakness rendering him housebound. Examination revealed upper motor neuron pattern of weakness of the lower limbs and loss of proprioception. Serum analysis revealed reduced caeruloplasmin and copper levels with raised zinc. Spinal imaging revealed subtle dorsal column intensity changes in C2-C7, confirmed with 3T MRI. A copper deficiency myeloneuropathy was diagnosed secondary to chronic use of a zinc-containing dental fixative paste...
August 8, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28777372/p53-inhibits-sp7-osterix-activity-in-the-transcriptional-program-of-osteoblast-differentiation
#7
Natalia Artigas, Beatriz Gámez, Mónica Cubillos-Rojas, Cristina Sánchez-de Diego, José Antonio Valer, Gabriel Pons, José Luis Rosa, Francesc Ventura
Osteoblast differentiation is achieved by activating a transcriptional network in which Dlx5, Runx2 and Osx/SP7 have fundamental roles. The tumour suppressor p53 exerts a repressive effect on bone development and remodelling through an unknown mechanism that inhibits the osteoblast differentiation programme. Here we report a physical and functional interaction between Osx and p53 gene products. Physical interaction was found between overexpressed proteins and involved a region adjacent to the OSX zinc fingers and the DNA-binding domain of p53...
August 4, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28776446/vegetable-relishes-high-in-%C3%AE-carotene-increase-the-iron-zinc-and-%C3%AE-carotene-nutritive-values-from-cereal-porridges
#8
Johanita Kruger, Annelies Breynaert, Luc Pieters, Nina Hermans
Iron, zinc and vitamin A deficiencies are serious public health problems in sub-Saharan Africa, which can be alleviated by dietary diversification. The effects of adding cowpea leaf (CL) and orange-fleshed sweet potato (OFSP) relishes to sorghum and maize porridges on iron, zinc and β-carotene contents and bioaccessibilities were determined. Despite the high iron content of the CL relish (14.59 mg/100 g), the vegetable relishes had little effect on the iron bioaccessibility from the cereal porridges. Importantly, the addition of the CL relish increased the percentage and amount of bioaccessible zinc 2- and 3-fold, respectively...
August 4, 2017: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/28772452/first-row-transition-metal-doping-in-calcium-phosphate-bioceramics-a-detailed-crystallographic-study
#9
Guillaume Renaudin, Sandrine Gomes, Jean-Marie Nedelec
Doped calcium phosphate bioceramics are promising materials for bone repair surgery because of their chemical resemblance to the mineral constituent of bone. Among these materials, BCP samples composed of hydroxyapatite (Ca10(PO₄)₆(OH)₂) and β-TCP (Ca₃(PO₄)₂) present a mineral analogy with the nano-multi-substituted hydroxyapatite bio-mineral part of bones. At the same time, doping can be used to tune the biological properties of these ceramics. This paper presents a general overview of the doping mechanisms of BCP samples using cations from the first-row transition metals (from manganese to zinc), with respect to the applied sintering temperature...
January 23, 2017: Materials
https://www.readbyqxmd.com/read/28771859/the-role-of-zip-transporters-and-group-f-bzip-transcription-factors-in-the-zn-deficiency-response-of-wheat-triticum-aestivum
#10
Nicholas P Evens, Peter Buchner, Lorraine E Williams, Malcolm J Hawkesford
Understanding the molecular basis of zinc (Zn) uptake and transport in staple cereal crops is critical for improving both Zn content and tolerance to low Zn soils. This study demonstrates the importance of F-group bZIP transcription factors and ZIP transporters in responses to Zn deficiency in wheat (Triticum aestivum). Seven F group TabZIP genes and fourteen ZIPs with homeologs were identified in hexaploid wheat. Promoter analysis revealed the presence of Zn-deficiency-response elements (ZDREs) in a number of the ZIPs...
August 3, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28770094/diagnostic-utility-of-zinc-protoporphyrin-to-detect-iron-deficiency-in-kenyan-preschool-children-a-community-based-survey
#11
Emily M Teshome, Andrew M Prentice, Ayşe Y Demir, Pauline E A Andang'o, Hans Verhoef
BACKGROUND: Zinc protoporphyrin (ZPP) has been used to screen and manage iron deficiency in individual children, but it has also been recommended to assess population iron status. The diagnostic utility of ZPP used in combination with haemoglobin concentration has not been evaluated in pre-school children. We aimed to a) identify factors associated with ZPP in children aged 12-36 months; b) assess the diagnostic performance and utility of ZPP, either alone or in combination with haemoglobin, to detect iron deficiency...
2017: BMC Hematology
https://www.readbyqxmd.com/read/28768674/diagnosis-of-acrodermatitis-enteropathica-in-resource-limited-settings
#12
Tanvi Dev, Gomathy Sethuraman
Acrodermatitis enteropathica (AE) is a rare inherited zinc deficiency that usually manifests in infancy within days in cases of bottlefed infants and days to weeks after weaning in breastfed infants. It is characterised by diarrhoea, dermatitis, alopecia and systemic symptoms. We report a case of acquired nutritional AE in a 6-month-old female infant who had diarrhoeal episodes and the characteristic dermatitis lesions in the acral and anogenital regions. She responded dramatically to oral zinc supplementation...
August 2, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28764581/skin-diseases-of-the-vulva-inflammatory-erosive-ulcerating-and-apocrine-gland-diseases-zinc-and-vitamin-deficiency-vulvodynia-and-vestibulodynia
#13
Freja Lærke Sand, Simon Francis Thomsen
Chronic, inflammatory and ulcerating mucocutaneous diseases that can affect the vulvar area are reviewed: lichen sclerosus, lichen planus, plasma cell vulvitis, complex aphthosis, Behcet's disease, pyoderma gangrenosum, metastatic Crohn's disease, dyskeratotic skin diseases (Hailey-Hailey disease and Darier's disease), autoimmune bullous diseases (mucous membrane pemphigoid and pemphigus vulgaris) and hidradenitis suppurativa. Also, vulvodynia and vestibulodynia, zinc and vitamin B deficiency are described.
August 1, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28763829/f-group-bzips-in-barley-a-role-in-zn-deficiency
#14
Ahmad Zulhilmi Nazri, Jonathan H C Griffin, Kerry A Peaston, Douglas G A Alexander-Webber, Lorraine E Williams
Zinc (Zn) deficiency negatively impacts the development and health of plants and affects crop yield. When experiencing low Zn, plants undergo an adaptive response to maintain Zn homeostasis. We provide further evidence for the role of F-group transcription factors, AtbZIP19 and AtbZIP23, in responding to Zn deficiency in Arabidopsis and demonstrate the sensitivity and specificity of this response. Despite their economic importance, the role of F-group bZIPs in cereal crops is largely unknown. Here we provide new insights by functionally characterizing these in barley (Hordeum vulgare), demonstrating an expanded number of F-group bZIPs (seven) compared to Arabidopsis...
August 1, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/28763004/the-linoleic-acid-dihomo-%C3%AE-linolenic-acid-ratio-la-dgla-an-emerging-biomarker-of-zn-status
#15
REVIEW
Marija Knez, James C R Stangoulis, Maria Glibetic, Elad Tako
Zinc (Zn) deficiency is a common aliment predicted to affect 17% of the world's population. Zinc is a vital micronutrient used for over 300 enzymatic reactions and multiple biochemical and structural processes in the body. Although whole blood, plasma, and urine zinc decrease in severe zinc deficiency, accurate assessment of zinc status, especially in mild to moderate deficiency, is difficult as studies with these biomarkers are often contradictory and inconsistent. Hence, as suggested by the World Health Organization, sensitive and specific biological markers of zinc status are still needed...
August 1, 2017: Nutrients
https://www.readbyqxmd.com/read/28761150/single-genetic-locus-improvement-of-iron-zinc-and-%C3%AE-carotene-content-in-rice-grains
#16
Simrat Pal Singh, Wilhelm Gruissem, Navreet K Bhullar
Nearly half of the world's population obtains its daily calories from rice grains, which lack or have insufficient levels of essential micronutrients. The deficiency of micronutrients vital for normal growth is a global health problem, and iron, zinc and vitamin A deficiencies are the most prevalent ones. We developed rice lines expressing Arabidopsis NICOTIANAMINE SYNTHASE 1 (AtNAS1), bean FERRITIN (PvFERRITIN), bacterial CAROTENE DESATURASE (CRTI) and maize PHYTOENE SYNTHASE (ZmPSY) in a single genetic locus in order to increase iron, zinc and β-carotene content in the rice endosperm...
July 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28760418/energy-and-nutrient-intake-of-infants-and-young-children-in-pastoralist-communities-of-ethiopia
#17
Girma Mengistu, Tibebu Moges, Aregash Samuel, Kaleab Baye
OBJECTIVE: Nutrient intake from complementary foods often is suboptimal in subsistent farming households of developing countries, but little is known about this in pastoralist communities. The aim of this study was to estimate the energy and nutrient intake of children ages 6 to 23 mo living in pastoralist communities of Ethiopia. METHOD: As part of the Ethiopian National Food Consumption Survey, 24-h dietary recall data were collected through in-home interviews from a nationally representative sample...
September 2017: Nutrition
https://www.readbyqxmd.com/read/28759006/re-expression-of-sall1-in-podocytes-protects-against-adriamycin-induced-nephrosis
#18
Yoshiko Hosoe-Nagai, Teruo Hidaka, Ayano Sonoda, Yu Sasaki, Kanae Yamamoto-Nonaka, Takuto Seki, Rin Asao, Eriko Tanaka, Juan Alejandro Oliva Trejo, Fumiko Kodama, Miyuki Takagi, Nobuhiro Tada, Takashi Ueno, Ryuichi Nishinakamura, Yasuhiko Tomino, Katsuhiko Asanuma
The highly conserved spalt (sal) gene family members encode proteins characterized by multiple double zinc finger motifs of the C2H2 type. Humans and mice each have four known Sal-like genes (SALL1-4 in humans and Sall1-4 in mice). Sall1 is known to have a crucial role in kidney development. To explore the significance of Sall1 in differentiated podocytes, we investigated podocyte-specific Sall1-deficient mice (Sall1 KO(p)°(d)°(/p)°(d)°) using a podocin-Cre/loxP system and siRNA Sall1 knockdown (Sall1 KD) podocytes...
July 31, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/28756600/trace-metals-in-the-urine-and-hair-of-a-population-in-an-endemic-arsenism-area
#19
Binggan Wei, Jiangping Yu, Jing Wang, Hairong Li, Linsheng Yang, Chang Kong
There have been few investigations of trace elements in the urine and hair of populations exposed to high levels of arsenic (As) in drinking water. Therefore, concentrations of selected metals in urine and hair samples from a population in a study area where arsenism was endemic and a control area were determined. It was found that the median concentrations of barium (Ba), cadmium (Cd), cobalt (Co), chromium (Cr), copper (Cu), manganese (Mn), molybdenum (Mo), nickel (Ni), lead (Pb), zinc (Zn), and As in the urine samples from the population in the study area were 3...
July 29, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28751976/manganese-transporter-slc39a14-deficiency-revealed-its-key-role-in-maintaining-manganese-homeostasis-in-mice
#20
Yongjuan Xin, Hong Gao, Jia Wang, Yuzhen Qiang, Mustapha Umar Imam, Yang Li, Jianyao Wang, Ruochen Zhang, Huizhen Zhang, Yingying Yu, Hao Wang, Haiyang Luo, Changhe Shi, Yuming Xu, Shintaro Hojyo, Toshiyuki Fukada, Junxia Min, Fudi Wang
SLC39A14 (also known as ZIP14), a member of the SLC39A transmembrane metal transporter family, has been reported to mediate the cellular uptake of iron and zinc. Recently, however, mutations in the SLC39A14 gene have been linked to manganese (Mn) accumulation in the brain and childhood-onset parkinsonism dystonia. It has therefore been suggested that SLC39A14 deficiency impairs hepatic Mn uptake and biliary excretion, resulting in the accumulation of Mn in the circulation and brain. To test this hypothesis, we generated and characterized global Slc39a14-knockout (Slc39a14(-/-) ) mice and hepatocyte-specific Slc39a14-knockout (Slc39a14(fl/fl);Alb-Cre(+) ) mice...
2017: Cell Discovery
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