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Zinc deficiency

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https://www.readbyqxmd.com/read/29791507/a-novel-mouse-model-of-campylobacter-jejuni-enteropathy-and-diarrhea
#1
Natasa Giallourou, Gregory L Medlock, David T Bolick, Pedro Hqs Medeiros, Solanka E Ledwaba, Glynis L Kolling, Kenneth Tung, Patricia Guerry, Jonathan R Swann, Richard L Guerrant
Campylobacter infections are among the leading bacterial causes of diarrhea and of 'environmental enteropathy' (EE) and growth failure worldwide. However, the lack of an inexpensive small animal model of enteric disease with Campylobacter has been a major limitation for understanding its pathogenesis, interventions or vaccine development. We describe a robust standard mouse model that can exhibit reproducible bloody diarrhea or growth failure, depending on the zinc or protein deficient diet and on antibiotic alteration of normal microbiota prior to infection...
May 23, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29779810/association-between-nutritional-blood-based-biomarkers-and-clinical-outcome-in-sarcopenia-patients
#2
Salah Gariballa, Awad Alessa
BACKGROUND: Although several micronutrients deficiency were reported to be associated with poor muscle function, however information on sarcopenia patients is still lacking. The aim of this report was to measure some micronutrients blood-based status in sarcopenia patients during both acute illness and recovery. DESIGN: We assessed nutritional status of randomly selected hospitalised patients using anthropometric, haematological and biochemical data at baseline, 6 weeks and at 6 months...
June 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29774825/dietary-zinc-modulates-matrix-metalloproteinases-in-traumatic-brain-injury
#3
Angus Scrimgeour, Christopher Carrigan, Michelle Lynn Condlin, Maria L Urso, Roland M van den Berg, Herman P M van Helden, Scott J Montain, Marloes J A Joosen
Animal models of mild traumatic brain injury (mTBI) provide opportunity to examine the extent to which dietary interventions can be used to improve recovery after injury. Animal studies also suggest that matrix metalloproteinases (MMPs) play a role in tissue remodeling post-TBI. Because dietary zinc (Zn) improved recovery in non-blast mTBI models, and the MMPs are Zn-requiring enzymes, we evaluated the effects of low- and adequate Zn diets on MMP expression and behavioral responses, following exposure to a single blast...
May 18, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29774076/the-human-somatostatin-receptor-type-2-as-an-imaging-and-suicide-reporter-gene-for-pluripotent-stem-cell-derived-therapy-of-myocardial-infarction
#4
Katrien Neyrinck, Natacha Breuls, Bryan Holvoet, Wouter Oosterlinck, Esther Wolfs, Hubert Vanbilloen, Olivier Gheysens, Robin Duelen, Willy Gsell, Ivo Lambrichts, Uwe Himmelreich, Catherine M Verfaillie, Maurilio Sampaolesi, Christophe M Deroose
Rationale: Pluripotent stem cells (PSCs) are being investigated as a cell source for regenerative medicine since they provide an infinitive pool of cells that are able to differentiate towards every cell type of the body. One possible therapeutic application involves the use of these cells to treat myocardial infarction (MI), a condition where billions of cardiomyocytes (CMs) are lost. Although several protocols have been developed to differentiate PSCs towards CMs, none of these provide a completely pure population, thereby still posing a risk for neoplastic teratoma formation...
2018: Theranostics
https://www.readbyqxmd.com/read/29773197/efficient-zinc-uptake-is-critical-for-the-ability-of-pseudomonas-aeruginosa-to-express-virulence-traits-and-colonize-the-human-lung
#5
Maria Chiara Mastropasqua, Iain Lamont, Lois W Martin, David W Reid, Melania D'Orazio, Andrea Battistoni
We have recently shown that Pseudomonas aeruginosa, an opportunistic pathogen that chronically infects the lungs of patients with cystic fibrosis (CF) and other forms of lung disease, is extremely efficient in recruiting zinc from the environment and that this capability is required for its ability to cause acute lung infections in mice. To verify that P. aeruginosa faces zinc shortage when colonizing the lungs of human patients, we analyzed the expression of three genes that are highly induced under conditions of zinc deficiency (zrmA, dksA2 and rpmE2), in bacteria in the sputum of patients with inflammatory lung disease...
July 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29768221/optimised-synthesis-of-zno-nano-fertiliser-through-green-chemistry-boosted-growth-dynamics-of-economically-important-l-esculentum
#6
Nyla Jabeen, Qaisar Maqbool, Tahira Bibi, Mudassar Nazar, Syed Z Hussain, Talib Hussain, Tariq Jan, Ishaq Ahmad, Malik Maaza, Sadaf Anwaar
Mounting-up economic losses to annual crops yield due to micronutrient deficiency, fertiliser inefficiency and increasing microbial invasions (e.g. Xanthomonas cempestri attack on tomatoes) are needed to be solved via nano-biotechnology. So keeping this in view, the authors' current study presents the new horizon in the field of nano-fertiliser with highly nutritive and preservative effect of green fabricated zinc oxide-nanostructures (ZnO-NSs) during Lycopersicum esculentum (tomato) growth dynamics. ZnO-NS prepared via green chemistry possesses highly homogenous crystalline structures well-characterised through ultraviolet and visible spectroscopy, Fourier transform infrared spectroscopy, X-ray diffraction and scanning electron microscope...
June 2018: IET Nanobiotechnology
https://www.readbyqxmd.com/read/29767675/a-comparison-of-methods-for-adjusting-biomarkers-of-iron-zinc-and-selenium-status-for-the-effect-of-inflammation-in-an-older-population-a-case-for-interleukin-6
#7
Sue O MacDonell, Jody C Miller, Michelle J Harper, Malcolm R Reid, Jillian J Haszard, Rosalind S Gibson, Lisa A Houghton
Background: Older people are at risk of micronutrient deficiencies, which can be under- or overestimated in the presence of inflammation. Several methods have been proposed to adjust for the effect of inflammation; however, to our knowledge, none have been investigated in older adults in whom chronic inflammation is common. Objective: We investigated the influence of various inflammation-adjustment methods on micronutrient biomarkers associated with anemia in older people living in aged-care facilities in New Zealand...
May 14, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29765417/zinc-promotes-adipose-derived-mesenchymal-stem-cell-proliferation-and-differentiation-towards-a-neuronal-fate
#8
Mi-Young Moon, Hyun Jung Kim, Bo Young Choi, Min Sohn, Tae Nyoung Chung, Sang Won Suh
Zinc is an essential element required for cell division, migration, and proliferation. Under zinc-deficient conditions, proliferation and differentiation of neural progenitors are significantly impaired. Adipose-derived mesenchymal stem cells (AD-MSCs) are multipotent stem cells that can differentiate into neurons. The aim of this study was to evaluate the effect of zinc on AD-MSC proliferation and differentiation. We initially examined the effect of zinc on stem cell proliferation at the undifferentiated stage...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29759248/qualitative-and-quantitative-analysis-of-human-nails-to-find-correlation-between-nutrients-and-vitamin-d-deficiency-using-libs-and-icp-aes
#9
M A Almessiere, R Altuwiriqi, M A Gondal, R K AlDakheel, H F Alotaibi
In this work, we analysed human fingernails of people who suffer from vitamin D deficiency using the laser-induced breakdown spectroscopy(LIBS) and inductively coupled plasma atomic emission spectroscopy (ICP-AES)techniques. The measurements have been conducted on 71 nail samples collected randomly from volunteers of different genders and ages ranged between 20 and 50 years. The main aim of this study is to find the correlation between vitamin D deficiency and the intensity of some dominated lines in the LIBS spectra...
August 1, 2018: Talanta
https://www.readbyqxmd.com/read/29757950/changes-in-arsenic-copper-iron-manganese-and-zinc-levels-resulting-from-the-application-of-poultry-litter-to-agricultural-soils
#10
Richard D Foust, Michael Phillips, Killian Hull, Dariia Yehorova
Twelve applications of poultry litter were made to a 2.1-ha field located in the Shenandoah Valley of Virginia, United States (USA), between March 1999 and August 2014. The field was planted with bermudagrass ( Cynodon dactylon ) and used as a pasture on an active farm. Copper, iron, manganese, zinc, and arsenic concentrations in the poultry litter were measured, and the application rates of these metals were calculated. The median application rates were: Cu, 1.32 kg/ha, Fe, 5.57 kg/ha, Mn, 1.80 kg/ha, Zn, 1...
May 14, 2018: Toxics
https://www.readbyqxmd.com/read/29757413/evaluation-of-iron-stores-by-zinc-protoporphyrin-analysis-in-blood-donors
#11
Richard R Gammon, Tania Kozel, Patrick Morel, Christopher Kendrick
Background: Zinc protoporphyrin (ZPP) testing has been studied previously as a substitute for ferritin (fer) testing of blood donors in determining iron stores. Objective: To determine whether ZPP testing could be performed using specimens collected via the capillary (cap) finger-stick (FS) method, similar to predonation hemoglobin (HB) testing. Also, we evaluated the correlation among FS HB, venous (ven) ZZP, FS ZPP, and ven fer levels as predictors of iron depletion...
May 11, 2018: Laboratory Medicine
https://www.readbyqxmd.com/read/29754190/allergic-and-immunologic-perspectives-of-inflammatory-bowel-disease
#12
REVIEW
Kofi Clarke, Jayakrishna Chintanaboina
Inflammatory bowel disease (IBD) is a chronic immune-mediated inflammatory condition primarily involving the gastrointestinal tract. It includes Crohn's disease (CD), ulcerative colitis (UC), and a less common phenotype-indeterminate colitis. It is thought to result from a complex interplay of environmental, microbial, and host factors including genetic factors, although the exact mechanism is not known. Dietary factors have been shown to play a role in the pathogenesis of IBD and can potentially alter the intestinal microbiota as well as disrupt the immune function in the gut...
May 12, 2018: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29752522/meta-qtl-analysis-of-seed-iron-and-zinc-concentration-and-content-in-common-bean-phaseolus-vulgaris-l
#13
Paulo Izquierdo, Carolina Astudillo, Matthew W Blair, Asif M Iqbal, Bodo Raatz, Karen A Cichy
Twelve meta-QTL for seed Fe and Zn concentration and/or content were identified from 87 QTL originating from seven population grown in sixteen field trials. These meta-QTL include 2 specific to iron, 2 specific to zinc and 8 that co-localize for iron and zinc concentrations and/or content. Common bean (Phaseolus vulgaris L.) is the most important legume for human consumption worldwide and it is an important source of microelements, especially iron and zinc. Bean biofortification breeding programs develop new varieties with high levels of Fe and Zn targeted for countries with human micronutrient deficiencies...
May 11, 2018: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/29747386/zinc-magnesium-selenium-and-depression-a-review-of-the-evidence-potential-mechanisms-and-implications
#14
REVIEW
Jessica Wang, Phoebe Um, Barbra A Dickerman, Jianghong Liu
Micronutrient deficiency and depression are major global health problems. Here, we first review recent empirical evidence of the association between several micronutrients—zinc, magnesium, selenium—and depression. We then present potential mechanisms of action and discuss the clinical implications for each micronutrient. Collectively, empirical evidence most strongly supports a positive association between zinc deficiency and the risk of depression and an inverse association between zinc supplementation and depressive symptoms...
May 9, 2018: Nutrients
https://www.readbyqxmd.com/read/29743987/critical-role-of-zinc-as-either-an-antioxidant-or-a-prooxidant-in-cellular-systems
#15
REVIEW
Sung Ryul Lee
Zinc is recognized as an essential trace metal required for human health; its deficiency is strongly associated with neuronal and immune system defects. Although zinc is a redox-inert metal, it functions as an antioxidant through the catalytic action of copper/zinc-superoxide dismutase, stabilization of membrane structure, protection of the protein sulfhydryl groups, and upregulation of the expression of metallothionein, which possesses a metal-binding capacity and also exhibits antioxidant functions. In addition, zinc suppresses anti-inflammatory responses that would otherwise augment oxidative stress...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29738427/dietary-zinc-intake-and-its-association-with-metabolic-syndrome-indicators-among-chinese-adults-an-analysis-of-the-china-nutritional-transition-cohort-survey-2015
#16
Yun Wang, Xiao-Fang Jia, Bing Zhang, Zhi-Hong Wang, Ji-Guo Zhang, Fei-Fei Huang, Chang Su, Yi-Fei Ouyang, Jian Zhao, Wen-Wen Du, Li Li, Hong-Ru Jiang, Ji Zhang, Hui-Jun Wang
The dietary zinc consumed in Chinese households has decreased over the past decade. However, the national dietary zinc intake in the last five years has seldom been investigated. Using data from 12,028 participants 18 to 64 years old (52.9% male) in the China Nutritional Transition Cohort Survey (CNTCS) 2015, we describe the intake of dietary zinc and the contributions of major foods and we examine the relationship between the level of dietary zinc intake and metabolic syndrome indicators, including blood pressure, fasting glucose, and triglycerides (TG), in Chinese adults...
May 8, 2018: Nutrients
https://www.readbyqxmd.com/read/29734621/elemental-and-isotopic-behaviour-of-zn-in-deccan-basalt-weathering-profiles-chemical-weathering-from-bedrock-to-laterite-and-links-to-zn-deficiency-in-tropical-soils
#17
Nils Suhr, Ronny Schoenberg, David Chew, Carolina Rosca, Mike Widdowson, Balz S Kamber
Zinc (Zn) is a micronutrient for organisms and essential for plant growth, therefore knowledge of its elemental cycling in the surface environment is important regarding wider aspects of human nutrition and health. To explore the nature of Zn cycling, we compared its weathering behaviour in a sub-recent regolith versus an ancient laterite profile of the Deccan Traps, India - an area of known soil Zn deficiency. We demonstrate that progressive breakdown of primary minerals and the associated formation of phyllosilicates and iron oxides leads to a depletion in Zn, ultimately resulting in a loss of 80% in lateritic residues...
April 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29729385/the-chinese-herbal-formula-zhibai-dihuang-granule-treat-yin-deficiency-heat-syndrome-rats-by-regulating-the-immune-responses
#18
Chang-Ming Liu, Jing Chen, Su Yang, Lian-Gen Mao, Ting-Ting Jiang, Hui-Hui Tu, Zhong-Liang Chen, Yu-Ting Hu, Lin Gan, Zhong-Jie Li, Ji-Cheng Li
ETHNOPHARMACOLOGICAL RELEVANCE: Zhibai Dihuang Granule (ZDG), a traditional Chinese medicine (TCM) made from eight Chinese herbs, has been classically used to treat Yin-deficiency-heat (YDH) syndrome. ZDG is well known with the therapeutic efficacy of nourishing Yin and decreasing internal heat in clinic, but the mechanism of ZDG's therapeutic effect is still not clear. MATERIALS AND METHODS: High doses of triiodothyronine (T3) were given intraperitoneally to induce Hyperthyroid YDH syndrome in SD rats...
May 2, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29728300/feasibility-of-measuring-zinc-in-human-nails-using-portable-x-ray-fluorescence
#19
David E B Fleming, Stephen R Bennett, Christopher J Frederickson
A variety of adverse health effects have been identified as resulting from zinc deficiency. Zinc supplementation may therefore be indicated for certain individuals or populations. A rapid and straightforward means of assessing zinc status in humans would be of considerable medical benefit. In this study, the feasibility of measuring zinc levels in human fingernails or toenails using a portable x-ray fluorescence technique was assessed. Whole nail models (or phantoms) were constructed from resin, and dosed with various concentrations of zinc...
April 26, 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29722842/a-dynamic-model-for-predicting-growth-in-zinc-deficient-stunted-infants-given-supplemental-zinc
#20
Meryl E Wastney, Christine M McDonald, Janet C King
Background: Zinc deficiency limits infant growth and increases susceptibility to infections, which further compromises growth. Zinc supplementation improves the growth of zinc-deficient stunted infants, but the amount, frequency, and duration of zinc supplementation required to restore growth in an individual child is unknown. A dynamic model of zinc metabolism that predicts changes in weight and length of zinc-deficient, stunted infants with dietary zinc would be useful to define effective zinc supplementation regimens...
May 1, 2018: American Journal of Clinical Nutrition
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