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https://www.readbyqxmd.com/read/28738758/laparoscopic-treated-neuralgia-after-inguinal-hernia-repair-case-report-and-literature-review
#1
M Engelen, K Dilen, E Baten
BACKGROUND: Neuralgia after inguinal hernia repair is a known but potential invalidating complication with a reported incidence of 10-12%. Diagnosis and treatment can be challenging. Based on a case report and literature review, disease aspects and treatment options including laparoscopic (triple) neurectomy are discussed. METHODS: A case of laparoscopic treated neuralgia after hernia inguinalis repair is reported. After an extensive MeSH-term based literature search, 26 articles were included for in-depth analysis and literature review...
July 25, 2017: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/28713862/metabolic-surgery-gastric-bypass-for-the-treatment-of-type-2-diabetes-mellitus
#2
REVIEW
Maria Del Pilar Quevedo, Mariano Palermo, Edgardo Serra, Marianela A Ackermann
Type 2 diabetes mellitus (T2DM) is one of the largest health emergencies of the 21st century given the worldwide increase of obesity during the last decades and its close association. T2DM is an inherited, polygenic and chronic disease caused by the interaction between several genetic variants in genes and the environment. The continuous search for new and more effective tools to achieve appropriate glycemic control became imperative in order to reduce long-term complications and mortality rates related to T2DM...
2017: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28710048/long-term-results-of-deep-brain-stimulation-of-the-anterior-cingulate-cortex-for-neuropathic-pain
#3
Sandra Gj Boccard, Simon J Prangnell, Laurie Pycroft, Binith Cheeran, Liz Moir, Erlick Ac Pereira, James J Fitzgerald, Alexander L Green, Tipu Z Aziz
BACKGROUND: Deep Brain Stimulation of the Anterior Cingulate Cortex is a recent technique that has shown some promising short-term results in patients with chronic refractory neuropathic pain. Three years after the first case-series, we assessed its efficacy on a larger cohort, with longer follow-up. METHODS: 24 patients (19 males; 49.1 years) with neuropathic pain underwent bilateral ACC DBS. Patient reported outcome measures were collected pre- and post-surgery, using the Numerical Rating Scale (NRS), Short-Form 36 quality of life (SF-36), McGill pain (MPQ) and EuroQol-5D questionnaires...
July 11, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28707286/intragastric-balloon-treatment-for-obesity-review-of-recent-studies
#4
REVIEW
Chinara M Tate, Allan Geliebter
INTRODUCTION: The FDA recently approved three intragastric balloon (IGB) devices, ReShape, ORBERA™, and Obalon for treatment of obesity. Given the high cost, complication risk, and invasiveness of bariatric surgery, IGB treatment may present a safer and lower cost option for weight reduction. IGBs are generally placed in the stomach endoscopically for up to 6 months to reduce gastric capacity, enhance feelings of fullness, and induce weight loss. The mechanism of action likely involves stimulation of gastric mechanoreceptors triggering short-acting vagal signals to brain regions implicated in satiety...
July 13, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28698663/medical-devices-for-the-treatment-of-obesity
#5
REVIEW
Phong Ching Lee, John Dixon
Obesity is a major public health concern that leads to numerous metabolic, mechanical and psychological complications. Although lifestyle interventions are the cornerstone of obesity management, subsequent physiological neurohormonal adaptations limit weight loss, strongly favour weight regain and counteract sustained weight loss. A range of effective therapies are therefore needed to manage this chronic relapsing disease. Bariatric surgery delivers substantial, durable weight loss but limited access to care, perceived high risks and costs restrict uptake...
July 12, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28680344/adma-sdma-and-l-arginine-may-be-novel-targets-in-pharmacotherapy-for-complications-due-to-cardiopulmonary-bypass
#6
Aydın Kahraman, Emre Mutlu, Mustafa Aldağ
BACKGROUND: In this study, the effects of olmesartan therapy on asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), L-arginine and inducible nitric oxide synthase (iNOS) levels were investigated in patients undergoing cardiopulmonary bypass. METHODS: Patients were randomly allocated to two groups, control and olmesartan. Olmesartan was administered 30 mg once a day beginning from preoperative day 5 to postoperative day 28 and on operation day...
January 2017: Journal of Medical Biochemistry
https://www.readbyqxmd.com/read/28677316/approaches-to-obesity-management
#7
Arianne N Sweeting, Ian D Caterson
This review will provide an overview of the currently available approaches to obesity management available in Australia, including the various approaches to lifestyle intervention, in addition to evaluating the safety and efficacy of adjuvant therapies, including pharmacotherapy and bariatric surgery.
July 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28668407/current-and-cutting-edge-interventions-for-the-treatment-of-obese-patients
#8
REVIEW
Jenanan Vairavamurthy, Lawrence J Cheskin, Dara L Kraitchman, Aravind Arepally, Clifford R Weiss
The number of people classified as obese, defined by the World Health Organization as having a body mass index ≥30, has been rising since the 1980s. Obesity is associated with comorbidities such as hypertension, diabetes mellitus, and nonalcoholic fatty liver disease. The current treatment paradigm emphasizes lifestyle modifications, including diet and exercise; however this approach produces only modest weight loss for many patients. When lifestyle modifications fail, the current "gold standard" therapy for obesity is bariatric surgery, including Roux-en-Y gastric bypass, sleeve gastrectomy, duodenal switch, and placement of an adjustable gastric band...
August 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28654022/recent-advances-in-the-management-of-gastroenteropancreatic-neuroendocrine-tumors-insights-from-the-2017-asco-gastrointestinal-cancers-symposium
#9
Renuka Iyer, Alexandria T Phan, J Philip Boudreaux
Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are rare malignancies that originate in the gastrointestinal system. GEP-NETs are typically indolent, but tumors known as "functional" secrete hormones that can lead to a complex of symptoms, including flushing, diarrhea, bronchospasm, and valvular heart disease. Management of patients with GEP-NETs requires a multidisciplinary approach, as treatment modalities include surgery, radiology, and pharmacotherapy. The available pharmacologic agents have increased in recently, and now include cytotoxic chemotherapies, somatostatin analogues, multitargeted tyrosine kinase inhibitors, mammalian target of rapamycin inhibitors, and radioisotopic radiotherapies...
April 2017: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/28651813/magnetic-oculomotor-prosthetics-for-acquired-nystagmus
#10
Parashkev Nachev, Geoff E Rose, David H Verity, Sanjay G Manohar, Kelly MacKenzie, Gill Adams, Maria Theodorou, Quentin A Pankhurst, Christopher Kennard
PURPOSE: Acquired nystagmus, a highly symptomatic consequence of damage to the substrates of oculomotor control, often is resistant to pharmacotherapy. Although heterogeneous in its neural cause, its expression is unified at the effector-the eye muscles themselves-where physical damping of the oscillation offers an alternative approach. Because direct surgical fixation would immobilize the globe, action at a distance is required to damp the oscillation at the point of fixation, allowing unhindered gaze shifts at other times...
June 23, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28647652/kinase-activity-in-recurring-primary-skull-base-chordomas-and-chondrosarcomas-identification-of-novel-pathways-of-oncogenesis-and-potential-drug-targets
#11
Philip Tatman, Joshua Osbun, Youssef Yakkioui, Sumanpret Kaur, Carolina Parada, Tina Busald, Donald Born, Owais Ahmad, Jing Zhang, Manuel Ferreira
OBJECTIVE: Chordomas and chondrosarcomas are tumors that can occur in the skull base. Currently, 45% of chordomas and 56% of chondrosarcomas recur within five years of surgery. The role of adjuvant therapy is highly debated. No pharmacotherapies have been approved by the FDA for chordomas or chondrosarcomas. The high propensity for recurrence and lack of definitive adjuvant therapy necessitates additional basic science research to identify molecular anomalies associated with recurrent disease...
June 21, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28647490/sex-biased-eicosanoid-biology-impact-for-sex-differences-in-inflammation-and-consequences-for-pharmacotherapy
#12
REVIEW
Simona Pace, Lidia Sautebin, Oliver Werz
The incidence, severity and progression of autoimmune diseases (e.g. scleroderma, multiple sclerosis, rheumatoid arthritis) and certain inflammatory diseases (e.g. asthma) are sex-biased where these pathologies dominate in women. However, other immune disorders such as sepsis, post-surgery infections and gout display higher incidence and severity in men. The molecular and cellular basis underlying this sex dimorphism remains incompletely elucidated but may provide important insights for sex-specific pharmacotherapy...
June 21, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28640778/a-cohort-study-of-blunt-cerebrovascular-injury-screening-in-children-are-they-just-little-adults
#13
Mackenzie R Cook, Cordelie E Witt, Robert H Bonow, Eileen M Bulger, Ken F Linnau, Saman Arbabi, Bryce R H Robinson, Joseph Cuschieri
BACKGROUND: Blunt cerebrovascular injuries (BCVI) are rare with nonspecific predictors, making optimal screening critical. Radiation concerns magnify these issues in children. The Eastern Association for the Surgery of Trauma (EAST) criteria, the Utah score (US) and the Denver criteria (DC) have been advocated for pediatric BCVI screening, though direct comparison is lacking. We hypothesized that current screening guidelines inaccurately identify pediatric BCVI. METHODS: This was a retrospective cohort study of pediatric trauma patients treated from 2005-2015 with radiographically confirmed BCVI...
June 20, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28631905/-rationale-of-pharmacotherapy-duration-in-patients-with-benign-prostatic-hyperplasia-a-clinical-morphological-study
#14
M E Sitdykova, D E Tsyplakov, E N Sitdykov, A R Nurtdinov
AIM: To investigate the nature of morphological alterations in the urinary bladder wall in BPH patients receiving pharmacotherapy to establish treatment time limits. MATERIALS AND METHODS: The study comprised 120 BPH patients who underwent a transvesical adenomectomy. Prior to the surgery, 110 patients received pharmacotherapy (-blockers and 5-reductase inhibitors) lasting from 1-6 months to 5-10 years. Preoperative evaluation included a standard diagnostic algorithm...
June 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/28622478/novel-nonsurgical-endoscopic-approaches-for-the-treatment-of-obesity
#15
Ryan T Hurt, Thomas H Frazier, Manpreet S Mundi
Globally, obesity is a leading cause of preventable death and is associated with >60 comorbid medical conditions, including 10 types of cancer that are strongly associated with body mass index. There are a number of traditional obesity treatments-for example, lifestyle management (eg, decreased caloric intake and increased expenditure), pharmacotherapy, and bariatric surgery. Recently, endoscopic approaches have emerged as a viable alternative for weight loss. Endoscopically placed intragastric balloons were introduced in the early 1980s for the treatment of medically complicated obesity but, unfortunately, had high rates of complications, such as premature deflation leading to obstruction...
June 1, 2017: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/28612613/-recent-overview-of-kidney-cancer-diagnostics-and-treatment
#16
J Marenčák, M Ondrušová, D Ondruš
The incidence of kidney cancer has increased in the majority of countries worldwide, and this disease has relatively high lethality. For many years, the Slovak Republic has been among the countries with the highest kidney cancer incidence, in particular in 2012 (according to global estimated values) in both genders, although mainly in females. In the last few years, the Czech Republic has had the highest incidence of kidney cancer worldwide. The use of imaging techniques such as ultrasound and computerized tomography has increased the detection of asymptomatic renal cell cancer...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/28558815/pathophysiology-of-chronic-subdural-haematoma-inflammation-angiogenesis-and-implications-for-pharmacotherapy
#17
REVIEW
Ellie Edlmann, Susan Giorgi-Coll, Peter C Whitfield, Keri L H Carpenter, Peter J Hutchinson
Chronic subdural haematoma (CSDH) is an encapsulated collection of blood and fluid on the surface of the brain. Historically considered a result of head trauma, recent evidence suggests there are more complex processes involved. Trauma may be absent or very minor and does not explain the progressive, chronic course of the condition. This review focuses on several key processes involved in CSDH development: angiogenesis, fibrinolysis and inflammation. The characteristic membrane surrounding the CSDH has been identified as a source of fluid exudation and haemorrhage...
May 30, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28557967/-the-assessment-of-the-impact-of-rehabilitation-on-the-pain-intensity-level-in-patients-with-herniated-nucleus-pulposus-of-the-intervertebral-disc
#18
Kamil Koszela, Sylwia Krukowska, Marta Woldańska-Okońska
Back pain may be caused by many factors. In many cases it is difficult to unambiguously determine a cause of the pathology, which can involve various structures in the spine. In this paper we will discuss the symptoms associated with the degenerative changes of the intervertebral disc, which involve, among others, its bulging, dislocation and pressure on the surrounding structures. These problems require an adequate clinical and imaging diagnostics in order to implement an appropriate treatment. In the first place, it should be based on the conservative methods (such as: pharmacotherapy, rehabilitation and lifestyle changes)...
May 23, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28551163/therapies-for-macular-edema-associated-with-branch-retinal-vein-occlusion-a-report-by-the-american-academy-of-ophthalmology
#19
Justis P Ehlers, Stephen J Kim, Steven Yeh, Jennifer E Thorne, Prithvi Mruthyunjaya, Scott D Schoenberger, Sophie J Bakri
PURPOSE: To evaluate the available evidence on the ocular safety and efficacy of current therapeutic alternatives for the management of macular edema (ME) secondary to branch retinal vein occlusion (BRVO). METHODS: Literature searches were last conducted on January 31, 2017, in PubMed with no date restrictions and limited to articles published in English, and in the Cochrane Database without language limitations. The searches yielded 321 citations, of which 109 were reviewed in full text and 27 were deemed appropriate for inclusion in this assessment...
May 24, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28544764/the-effectiveness-of-interventions-to-treat-hypothalamic-obesity-in-survivors-of-childhood-brain-tumours-a-systematic-review
#20
REVIEW
K-W Wang, R Chau, A Fleming, L Banfield, S K Singh, D L Johnston, S M Zelcer, S R Rassekh, S Burrow, M Valencia, R J de Souza, L Thabane, M C Samaan
BACKGROUND: Survivors of childhood brain tumours (SCBT) are at risk of type 2 diabetes and cardiovascular diseases. Obesity is a major driver of cardiometabolic diseases in the general population, and interventions that tackle obesity may lower the risk of these chronic diseases. The goal of this systematic review was to summarize current evidence for the presence of interventions to manage obesity, including hypothalamic obesity, in SCBT. METHODS: The primary outcome of this review was the body mass index z-score change from baseline to the end of the intervention and/or follow-up...
May 22, 2017: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
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