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Tyler A Johnson, Laura Milan-Lobo, Tao Che, Madeline Ferwerda, Eptisam Lambo, Nicole L McIntosh, Fei Li, Li He, Nicholas Lorig-Roach, Phillip Crews, Jennifer Lynne Whistler
Opioid therapeutics are excellent analgesics, whose utility is compromised by dependence. Morphine (1) and its clinically relevant derivatives such as OxyContin® (4), Vicodin® (5) and Dilaudid® (6) are "biased" agonists at the µ opioid receptor (OR), wherein they engage G-protein signaling but poorly engage β-arrestin and the endocytic machinery. In contrast, the endorphins, met-enkephalin (14) and β-endorphin (15), endogenous peptide agonists for ORs, are more potent analgesics then 1, show reduced liability for tolerance and dependence, and engage both G-protein and β-arrestin pathways as "balanced" agonists...
October 17, 2016: ACS Chemical Neuroscience
Kora DeBeck, Evan Wood, Huiru Dong, Sabina Dobrer, Kanna Hayashi, Julio Montaner, Thomas Kerr
No abstract text is available yet for this article.
August 2016: International Journal on Drug Policy
Emily C McNaughton, Paul M Coplan, Ryan A Black, Sarah E Weber, Howard D Chilcoat, Stephen F Butler
BACKGROUND: Reformulating opioid analgesics to deter abuse is one approach toward improving their benefit-risk balance. To assess sentiment and attempts to defeat these products among difficult-to-reach populations of prescription drug abusers, evaluation of posts on Internet forums regarding reformulated products may be useful. A reformulated version of OxyContin (extended-release oxycodone) with physicochemical properties to deter abuse presented an opportunity to evaluate posts about the reformulation in online discussions...
2014: Journal of Medical Internet Research
Andrew K Chang, Polly E Bijur, Jason B Lupow, E John Gallagher
OBJECTIVES: The objective was to test the efficacy and safety of 2 mg of intravenous (IV) hydromorphone (Dilaudid) against "usual care" in emergency department (ED) patients with acute severe pain. METHODS: This was a randomized clinical trial. Patients allocated to 2 mg of IV hydromorphone received their medication in a single dose. Those randomized to usual care received any IV opioid, with type, dose, and frequency chosen by the ED attending. All patients received 2 L/min...
February 2013: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
Morgan Eutermoser, Kristen Nordenholz
A 34-year-old male presented to the emergency department with a 3-hour complaint of pain in the right lower quadrant and right testicle. He stated that his pain began suddenly while standing at work. On physical examination, he had a small, firm, unreducible bulge in his right inguinal canal and an enlarged right scrotum. The patient was placed in trendelenburg position; intravenous fentanyl, valium, and dilaudid were administered; and surgery consult was obtained. A testicular ultrasonogram (Figure) was obtained owing to continued pain in the right scrotum and inability to evaluate the testicle...
February 2012: Western Journal of Emergency Medicine
James W Jones, Laurence B McCullough
You received a call advising that Mr S. H. Irk was in the emergency room having considerable wound pain following an above-knee amputation you performed 6 months ago. You discharged him from your clinic 6 weeks postoperatively to his primary care physician, still complaining of more pain than usual. Your examination, clinical lab tests, and X-rays do not reveal any serious problems, but he is writhing in pain and begging for relief. Mr Irk has been to a number of different physicians in the interlude including a chiropractor, a pain specialist, several primary care physicians, and a psychiatrist without relief...
February 2012: Journal of Vascular Surgery
S Kamran, B D Wright
Objectives. To report complications associated with implant of the intrathecal drug delivery systems (IDDS). Patients and Methods. A retrospective review of the implant database was undertaken to determine various complications associated with the IDDS. A total of 122 patients were reviewed, 97 included in the final analysis, 25 excluded due to incomplete data. The complications of excluded patients were reviewed separately. The complications were divided in to categories pharmacologic, equipment, procedural, programming errors and psychological...
July 2001: Neuromodulation: Journal of the International Neuromodulation Society
No abstract text is available yet for this article.
August 1945: Journal of Pharmacology and Experimental Therapeutics
A H Maloney
No abstract text is available yet for this article.
September 1940: Journal of the National Medical Association
A H Maloney
No abstract text is available yet for this article.
May 1937: Journal of the National Medical Association
Meredith Smith, Andrew Rosenblum, Mark Parrino, Chunki Fong, Salvatore Colucci
AIM: To determine concurrent validity of self-reported misuse of prescription opioids. DESIGN AND SETTING: Cross-sectional study in five U.S. methadone maintenance programs. PARTICIPANTS: 92 addicts. MEASUREMENTS: Self-reported questionnaire assessing past-month misuse of 14 opioid analgesics, and color photographs of five opioid analgesics with instructions to mark those used in the past month "to get high." Concordance between self-report and photograph endorsement was assessed via Kappa statistic...
August 2010: Substance Use & Misuse
Paul Gramenz, David Roberts, Laura Schrag
BACKGROUND: Accidental intra-arterial (IA) injection of a drug of abuse is a rare but potentially limb-threatening occurrence that causes rhabdomyolysis and limb ischemia through a number of mechanisms. Methadone tablets contain microcrystalline cellulose, which has been shown to cause gangrene in animal studies. OBJECTIVES: We present a case of IA injection of methadone tablets dissolved in water, followed by a brief review of the literature. CASE REPORT: A former heroin abuser presented to the Emergency Department after injecting 10 10-mg methadone tablets dissolved in water into his femoral artery...
September 2010: Journal of Emergency Medicine
Flutura Bardhi, Stephen J Sifaneck, Bruce D Johnson, Eloise Dunlap
Recent survey research has documented important increases during the 2000s in the misuse and abuse of several prescription drugs (Vicodin, Percocet, Codeine, Dilaudid, Xanax, Klonopin, Valium, Ativan, Adderall, Ritalin, among others). This article focuses upon the patterns of pill use and misuse among young women who are middle-class white and college-educated, and they are also experienced marijuana users who report recreational consumption of other illegal drugs. The ethnographic data provides insights about various ways and reasons that such prescription pill misuse occurs among 12 college-educated, (upper) middle-class, white/Asian women in their 20s who were involved in a major ethnographic study of marijuana and blunts...
2007: Contemporary Drug Problems
(no author information available yet)
No abstract text is available yet for this article.
August 2008: Nursing Law's Regan Report
(no author information available yet)
No abstract text is available yet for this article.
June 2008: Nursing Law's Regan Report
Nathaniel Katz, Kathrine Fernandez, Alan Chang, Christine Benoit, Stephen F Butler
INTRODUCTION: Prescription opioid misuse is a growing problem in the United States. There are limited data to illuminate the nature of this issue. The Internet seems to be a novel approach in surveying populations of opioid users. An Internet-based survey of nonmedical opioid users visiting informational drug websites was used to measure rates of nonmedical use and characterize users. METHODS: The prescription opioid module of the Addiction Severity Index Multimedia Version Connect was adapted to include variables such as favorite opioid...
July 2008: Clinical Journal of Pain
No abstract text is available yet for this article.
March 1949: Journal of Pharmacology and Experimental Therapeutics
No abstract text is available yet for this article.
March 1949: Journal of the Tennessee State Medical Association
Meredith Y Smith, J David Haddox, Michael E Di Marino
Over the past decade, the misuse and abuse of opioid medications in the United States has risen dramatically. Although data show a substantial variation in the nonmedical use of individual opioids, relatively little is known about risk factors for the nonmedical use of specific opioid products. This study compared the prevalence and correlates of the nonmedical use of oral immediate-release hydromorphone (marketed under the brand name of Dilaudid), versus that of hydrocodone combination products using a nationally representative sample of the civilian noninstitutionalized United States population aged 12 years or older...
2007: Journal of Pain & Palliative Care Pharmacotherapy
Daniel M Sciubba, Li-Mei Lin, James E Conway, Ali Bydon, Ziya L Gokaslan, Khaled Kebaish
STUDY DESIGN: Case report. OBJECTIVE: To report a case and review the literature on development of scoliosis following intrathecally placed opioid pump for chronic low back pain. SUMMARY OF BACKGROUND DATA: Intrathecal opioid administration is a technique currently indicated for the management of chronic pain syndromes. Despite evidence of scoliosis occurring after baclofen pump insertion, there has been no evidence that development of scoliosis occurs following implantation of an intrathecally placed opioid pump for treatment of lower back pain (LBP)...
November 15, 2007: Spine
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