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https://www.readbyqxmd.com/read/28422300/platelet-reactivity-in-response-to-loading-dose-of-atorvastatin-or-rosuvastatin-in-patients-with-stable-coronary-disease-before-percutaneous-coronary-intervention-the-statiplat-randomized-study
#1
Cosmo Godino, Anna Giulia Pavon, Antonio Mangieri, Anna Salerno, Michela Cera, Alberto Monello, Alaide Chieffo, Valeria Magni, Alberto Cappelletti, Alberto Margonato, Antonio Colombo
BACKGROUND: The acute effects of statin loading dose (LD) on platelet reactivity in patients with chronic stable angina (CSA) are not completely clear. HYPOTHESIS: We hypothesized that LDs of atorvastatin and rosuvastatin have different pharmacodynamic acute effects on platelet aggregability in CSA patients with baseline normal platelet reactivity while on dual antiplatelet therapy (DAPT). METHODS: From September 2011 to February 2014, all consecutive CSA patients on chronic DAPT (aspirin and clopidogrel) were evaluated before elective percutaneous coronary intervention (PCI)...
April 19, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28355945/late-life-depression
#2
Filippo Cieri, Roberto Esposito, Nicoletta Cera, Valentina Pieramico, Armando Tartaro, Massimo di Giannantonio
Late-life depression (LLD) is a common emotional and mental disability in the elderly population characterized by the presence of depressed mood, the loss of interest or pleasure in daily activities, and other depression symptoms. It has a serious effect on the quality of life of elderly individuals and increases their risk of developing physical and mental diseases. It is an important area of research, given the growing elderly population. Brain functional connectivity modifications represent one of the neurobiological biomarker for LLD even if to date remains poorly understood...
January 1, 2017: Journal of Geriatric Psychiatry and Neurology
https://www.readbyqxmd.com/read/28346624/association-of-group-prenatal-care-in-us-family-medicine-residencies-with-maternity-care-practice-a-cera-secondary-data-analysis
#3
Wendy B Barr, Sebastian T Tong, Nicholas M LeFevre
BACKGROUND AND OBJECTIVES: Group prenatal care has been shown to improve both maternal and neonatal outcomes. With increasing adaption of group prenatal care by family medicine residencies, this model may serve as a potential method to increase exposure to and interest in maternity care among trainees. This study aims to describe the penetration, regional and program variations, and potential impacts on future maternity care practice of group prenatal care in US family medicine residencies...
March 2017: Family Medicine
https://www.readbyqxmd.com/read/28346619/scope-of-practice-and-family-medicine-match-rates-results-from-a-cera-clerkship-directors-survey
#4
David Anthony, Jordan White, Katherine Margo, Derjung M Tarn
BACKGROUND AND OBJECTIVES: Family medicine clerkship directors depend on community preceptors to teach and attract medical students to family medicine. Many community preceptors do not provide the full range of family medicine services, and some are not family physicians. This study aimed to determine the types of practices in which family medicine clerkship students train and whether scope of practice is associated with family medicine Match rates. METHODS: Data were collected as part of the 2014 Council of Academic Family Medicine Educational Research Alliance (CERA) Family Medicine Clerkship Director Survey...
March 2017: Family Medicine
https://www.readbyqxmd.com/read/28337386/long-term-clinical-outcomes-of-patients-with-rheumatoid-arthritis-and-concomitant-coronary-artery-disease
#5
Marco Spartera, Cosmo Godino, Elena Baldissera, Corrado Campochiaro, Ketty La Spina, Patrizia Aiello, Anna Salerno, Michela Cera, Valeria Magni, Richard J Jabbour, Lorenzo Dagna, Moreno Tresoldi, Alberto Cappelletti, Ottavio Alfieri, Antonio Colombo, Maria Grazia Sabbadini, Alberto Margonato
BACKGROUND: Rheumatoid arthritis (RA) is associated with high morbidity and mortality predominately due to increased cardiovascular risk. Few reports are available regarding the management of coronary artery disease (CAD) in RA patients and the long-term clinical outcomes after coronary revascularization. METHODS AND RESULTS: All consecutive patients with RA were identified by retrospective review at a rheumatology tertiary center in Milan, Italy between 2001 and 2013...
2017: American Journal of Cardiovascular Disease
https://www.readbyqxmd.com/read/28296276/report-on-an-anti-doping-operation-in-guadeloupe-high-number-of-positive-cases-and-inferences-about-doping-habits
#6
A Marchand, C Buisson, L Martin, J-A Martin, A Molina, D Ressiot
Anti-doping controls in non-major events are relatively infrequent and athletes that compete only in these events are less likely to be controlled. The French Anti-Doping Agency carried out an anti-doping operation during a regional cycling competition in Guadeloupe. The urine and serum samples were analyzed by the French anti-doping laboratory. Out of 42 athletes, 7 were positive for one or more substances prohibited by the World Anti-Doping Agency. Four serum samples contained continuous erythropoietin receptor activator (CERA) and one a recombinant erythropoietin...
March 11, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28294177/rational-design-of-protein-c-activators
#7
Sergio Barranco-Medina, Mary Murphy, Leslie Pelc, Zhiwei Chen, Enrico Di Cera, Nicola Pozzi
In addition to its procoagulant and proinflammatory functions mediated by cleavage of fibrinogen and PAR1, the trypsin-like protease thrombin activates the anticoagulant protein C in a reaction that requires the cofactor thrombomodulin and the endothelial protein C receptor. Once in the circulation, activated protein C functions as an anticoagulant, anti-inflammatory and regenerative factor. Hence, availability of a protein C activator would afford a therapeutic for patients suffering from thrombotic disorders and a diagnostic tool for monitoring the level of protein C in plasma...
March 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28283091/cyp1a1-i462v-polymorphism-is-associated-with-reduced-genotoxicity-in-yeast-despite-positive-association-with-increased-cancer-risk
#8
Julian Freedland, Cinzia Cera, Michael Fasullo
CYP1A1 functions in detoxifying xenobiotics but occasionally converts compounds into potent genotoxins. CYP1A1 activates polyaromatic hydrocarbons, such as benzo[a]pyrene 7,8 dihydrodiol (BaP-DHD), rendering them genotoxic. Particular alleles of CYP1A1, such as CYP1A1 I462V have been correlated with a higher incidence of breast and lung cancer, but it is unknown whether these variants express enzymes in vivo that are more potent in generating genotoxins. We individually expressed CYP1A1 (CYP1A1.1), CYP1A1 T461N (CYP1A1...
March 2017: Mutation Research
https://www.readbyqxmd.com/read/28261401/training-family-medicine-residents-to-perform-home-visits-a-cera-survey
#9
Tomoko Sairenji, Stephen A Wilson, Frank D'Amico, Lars E Peterson
BACKGROUND : Home visits have been shown to improve quality of care, save money, and improve outcomes. Primary care physicians are in an ideal position to provide these visits; of note, the Accreditation Council for Graduate Medical Education no longer requires home visits as a component of family medicine residency training. OBJECTIVE : To investigate changes in home visit numbers and expectations, attitudes, and approaches to training among family medicine residency program directors...
February 2017: Journal of Graduate Medical Education
https://www.readbyqxmd.com/read/28218936/a-national-cera-study-of-the-use-of-laborists-in-family-medicine-residency-training
#10
Robert A Baldor, Christine Chang Pecci, Gerardo Moreno, Virginia Van Duyne, Stacy E Potts
BACKGROUND AND OBJECTIVES: Little is known about the impact of laborists (which we defined as "clinicians dedicated to providing L&D care services in the hospital environment for pregnant patients, regardless of who provided the prenatal care" for this survey) on family medicine residency training. We surveyed family medicine residency directors to assess characteristics about laborist services and their involvement in family medicine residency teaching. METHODS: Questions were included in the 2015 Council of Academic Family Medicine Educational Research Alliance (CERA) survey of family medicine residency directors...
February 2017: Family Medicine
https://www.readbyqxmd.com/read/28177547/iron-catalyzed-c-h-alkynylation-through-triazole-assistance-expedient-access-to-bioactive-heterocycles
#11
Gianpiero Cera, Tobias Haven, Lutz Ackermann
Triazole assistance enabled the first iron-catalyzed C-H alkynylation of arenes, heteroarenes, and alkenes. The modular TAM directing group set the stage for a sequential C-H alkynylation/annulation strategy with ample scope, enabling the iron-catalyzed assembly of isoquinolones, pyridones, pyrrolones, and isoindolinones with high levels of chemo-, site-, and regioselectivity.
March 13, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28176262/modifications-in-resting-state-functional-anticorrelation-between-default-mode-network-and-dorsal-attention-network-comparison-among-young-adults-healthy-elders-and-mild-cognitive-impairment-patients
#12
Roberto Esposito, Filippo Cieri, Piero Chiacchiaretta, Nicoletta Cera, Mariella Lauriola, Massimo Di Giannantonio, Armando Tartaro, Antonio Ferretti
Resting state brain activity incorporates different components, including the Default Mode Network and the Dorsal Attention Network, also known as task-negative network and task-positive network respectively. These two networks typically show an anticorrelated activity during both spontaneous oscillations and task execution. However modifications of this anticorrelated activity pattern with age and pathology are still unclear. The present study aimed to investigate differences in resting state Default Mode Network-Dorsal Attention Network functional anticorrelation among young adults, healthy elders and Mild Cognitive Impairment patients...
February 7, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28044985/radiation-dose-absorbed-by-operators-during-transradial-percutaneous-coronary-procedures-comparing-different-protective-drapes-the-radiation-study
#13
Alessandro Sciahbasi, Stefano Rigattieri, Alessandro Sarandrea, Maria Cera, Cristian Di Russo, Silvio Fedele, Silvio Romano, Francesco Rocco Pugliese, Maria Penco
AIMS: To compare different radiation protection drapes in term of radiation dose absorbed by operators during right or left transradial procedures. METHODS AND RESULTS: Patients who underwent transradial coronary procedures were randomized initially in 4 groups: Group 1 (no drapes), Group 2 (drape on patient's arm), Group 3 (pelvic drape), Group 4 (combined arm and pelvic drapes). Subsequently each group was further randomized to right or left radial access. The primary end-point was the operator radiation dose at thorax...
January 3, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28004857/polywhips-directional-particle-transport-by-gradient-directed-growth-and-stiffening-of-supramolecular-assemblies
#14
Luca Cera, Leonardo Chiappisi, Christoph Böttcher, Andrea Schulz, Stefan Schoder, Michael Gradzielski, Christoph A Schalley
Growth of rigid rods occurs via supramolecular assembly of a nonconjugated π-donor π-acceptor monomer and is triggered by a NaCl gradient. The mechanical stiffness of this material is controlled by the local salt concentration and is ion specific. The continuous and well-controlled growth process is exploited to power the directional transport of sub-millimeter polymer particles.
February 2017: Advanced Materials
https://www.readbyqxmd.com/read/27990008/anemia-treatment-by-erythropoiesis-stimulating-agents-during-the-6-months-before-initiation-of-hemodialysis-comparison-between-darbepoetin-alfa-and-continuous-erythropoietin-receptor-activator
#15
Tadashi Yoshida, Matsuhiko Hayashi
Anemia in chronic kidney disease (CKD) is a risk factor for cardiovascular diseases and is treated by long-acting erythropoiesis-stimulating agents (ESA). Although results of previous studies showed that the hemoglobin level could not be maintained at initiation of dialysis in CKD patients treated with recombinant human erythropoietin, it remains undetermined if long-acting ESA are effective to prevent the progression of anemia at initiation of dialysis. In the present study, hemoglobin levels in 40 CKD patients treated with darbepoetin alfa (DA) and 15 CKD patients treated with a continuous erythropoietin receptor activator (CERA) were retrospectively compared during the 6 months period prior to initiation of dialysis...
December 19, 2016: Keio Journal of Medicine
https://www.readbyqxmd.com/read/27969897/tct-531-intracoronary-vs-intravenous-adenosine-for-fractional-flow-reserve-measurement-a-meta-analysis
#16
Stefano Rigattieri, Giuseppe Biondi-Zoccai, Alessandro Sciahbasi, Cristian Di RUsso, Maria Cera, Jonathan Beaudoin, Silvio Fedele, Francesco Pugliese
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27965501/effect-of-surface-treatments-on-the-bond-strength-to-turkom-cera-all-ceramic-material
#17
Abdul Aa Razak, Mohamed I Abu-Hassan, Bandar Ma Al-Makramani, Fuad A Al-Sanabani, Ibrahim Z Al-Shami, Hosain M Almansour
AIM: The aim of this study was to evaluate the effect of surface treatments on shear bond strength (SBS) of Turkom-Cera (Turkom-Ceramic (M) Sdn. Bhd., Puchong, Malaysia) all-ceramic material cemented with resin cement Panavia-F (Kuraray Medical Inc., Okayama, Japan). MATERIALS AND METHODS: Forty Turkom-Cera ceramic disks (10 mm × 3 mm) were prepared and randomly divided into four groups. The disks were wet ground to 1000-grit and subjected to four surface treatments: (1) No treatment (Control), (2) sandblasting, (3) silane application, and (4) sandblasting + silane...
November 1, 2016: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/27897969/satb2-determines-mirna-expression-and-long-term-memory-in-the-adult-central-nervous-system
#18
Clemens Jaitner, Chethan Reddy, Andreas Abentung, Nigel Whittle, Dietmar Rieder, Andrea Delekate, Martin Korte, Gaurav Jain, Andre Fischer, Farahnaz Sananbenesi, Isabella Cera, Nicolas Singewald, Georg Dechant, Galina Apostolova
SATB2 is a risk locus for schizophrenia and encodes a DNA-binding protein that regulates higher-order chromatin configuration. In the adult brain Satb2 is almost exclusively expressed in pyramidal neurons of two brain regions important for memory formation, the cerebral cortex and the CA1-hippocampal field. Here we show that Satb2 is required for key hippocampal functions since deletion of Satb2 from the adult mouse forebrain prevents the stabilization of synaptic long-term potentiation and markedly impairs long-term fear and object discrimination memory...
November 29, 2016: ELife
https://www.readbyqxmd.com/read/27871009/malignant-nerve-sheath-tumor-involving-glossopharyngeal-vagus-and-spinal-nerve-with-intracranial-extracranial-extension-and-systemic-metastases-in-a-patient-with-type-1-neurofibromatosis-a-case-report
#19
José Raúl Guerra-Mora, Juan D Del Castillo-Calcáneo, María Elena Córdoba-Mosqueda, Jorge Yáñez-Castro, Ulises García-González, Eduardo Soriano-Navarro, Leticia Llamas-Ceras, Rosa María Vicuña-González
INTRODUCTION: Intracranial malignant peripheral nerve sheath tumors are an extremely rare pathology with a high morbidity and mortality. Epidemiological, clinical and prognostic data are scarce and with little certainty in the literature. The aim of this paper is to report for first time in English literature, the case of a patient with type 1 neurofibromatosis, who presented a malignant peripheral nerve sheath tumor that involved the left glossopharyngeal, vagus and spinal nerves with intracranial and extracranial extension through jugular foramen and systemic metastases...
2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27859873/impact-of-an-intervention-on-the-prescription-of-aliskiren-after-new-evidence-on-safety-reported
#20
Isabel Rosich Martí, Alejandro Allepuz, Gemma Rodriguez Palomar, Francesca Ortin Font, Maria Soler Cera
PURPOSE: The purpose of the study is to analyze the impact of an intervention to disseminate safety alerts on the utilization of Aliskiren added to angiotensin converting enzyme inhibitor (ACEI) or an angiotensin-receptor blocker (ARB). METHODS: Quasi-experimental design (non-randomized intervention) comparing the utilization of Aliskiren + ACEI or ARB in a primary care area-intervention (PCA-I) with a primary care area-control (PCA-C) following a safety alert...
November 16, 2016: Pharmacoepidemiology and Drug Safety
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