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https://www.readbyqxmd.com/read/28506654/effect-of-number-of-firings-on-the-color-and-translucency-of-ceramic-core-materials-with-veneer-ceramic-of-different-thicknesses
#1
Funda Bayindir, Ozlem Ozbayram
STATEMENT OF PROBLEM: Whether masking or translucency should be the goal for achieving an esthetic restoration with ceramic materials is unknown. PURPOSE: The purpose of this in vitro study was to examine the effect of the number of firings on the color and translucency of ceramic core material with different thicknesses of veneer ceramic. MATERIAL AND METHODS: Three different ceramic systems were used: IPS Empress (IE), IPS e.max Press (IEP), and Turkom Cera (TC)...
May 12, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28494585/induced-fit-is-a-special-case-of-conformational-selection
#2
Pradipta Chakraborty, Enrico Di Cera
Conformational selection (CS) and induced fit (IF) are two widely used interpretations of binding of a ligand to biological macromolecules. Both mechanisms envision a two-step reaction in which a conformational transition either precedes (CS) or follows (IF) the binding step. Under pseudo-first-order conditions where the ligand is in excess compared to the macromolecule, both mechanisms produce two relaxations. A fast one eventually increases linearly with ligand concentration and reflects the binding interaction...
May 22, 2017: Biochemistry
https://www.readbyqxmd.com/read/28494037/effect-of-abutment-preparation-and-fatigue-loading-in-a-moist-environment-on-the-fracture-resistance-of-the-one-piece-zirconia-dental-implant
#3
Mohamed Kamel, Tritala K Vaidyanathan, Robert Flinton
PURPOSE: One-piece zirconia dental implants have been widely used in Europe for many years. This in vitro study was done to evaluate the effect of abutment preparation and fatigue (cyclic) loading in a moist environment on the fracture resistance of the one-piece zirconia dental implant. MATERIALS AND METHODS: Twenty-four Cera Root zirconium oxide dental implants, divided into three groups of eight, were used in this study: group 1 (control group): implants with no preparation, tested in a dry environment; group 2: implants with no preparation, tested in a moist environment (simulating clinical conditions); and group 3: implants after abutment preparation tested in a moist environment...
May 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28476544/rirs-in-the-elderly-is-it-feasible-and-safe
#4
F Berardinelli, P De Francesco, M Marchioni, N Cera, S Proietti, D Hennessey, O Dalpiaz, C Cracco, C Scoffone, G Giusti, L Cindolo, L Schips
BACKGROUND: The aim of this study was to compare the safety and efficacy of RIRS in men ≥65 years to those <65 years. MATERIALS AND METHODS: Patients who underwent RIRS were prospectively collected from March 2013 to March 2014 in 5 European centers. Perioperative outcomes and complications in elderly men were compared with men <65 years. Univariable and multivariable analyses were performed for factors predicting overall complications. The groups were compared using Mann-Whitney U test...
May 3, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28454793/determinants-of-operator-radiation-exposure-during-percutaneous-coronary-procedures
#5
Alessandro Sciahbasi, Stefano Rigattieri, Alessandro Sarandrea, Maria Cera, Cristian Di Russo, Silvio Fedele, Roberto Patrizi, Silvio Romano, Francesco Rocco Pugliese, Maria Penco, Samir B Pancholy
BACKGROUND: Radiation exposure is an important issue for interventional cardiologists that is often underevaluated. Our aim was to evaluate determinants of operator radiation exposure during percutaneous coronary procedures. METHODS: The RADIANT (NCT01974453) is a prospective, single-center observational study involving 4 expert operators and 2 fellows performing percutaneous coronary procedures. The operator radiation dose was evaluated using dedicated electronic dosimeters in 2,028 procedures: 1,897 transradial access (TRA; 1,120 right and 777 left TRA) and 131 transfemoral access (TFA)...
May 2017: American Heart Journal
https://www.readbyqxmd.com/read/28436563/an-in-vitro-system-for-measuring-genotoxicity-mediated-by-human-cyp3a4-in-saccharomyces-cerevisiae
#6
Michael Fasullo, Julian Freedland, Nicholas St John, Cinzia Cera, Patricia Egner, Matthew Hartog, Xinxin Ding
P450 activity is required to metabolically activate many chemical carcinogens, rendering them highly genotoxic. CYP3A4 is the most abundantly expressed P450 enzyme in the liver, accounting for most drug metabolism and constituting 50% of all hepatic P450 activity. CYP3A4 is also expressed in extrahepatic tissues, including the intestine. However, the role of CYP3A4 in activating chemical carcinogens into potent genotoxins is unclear. To facilitate efforts to determine whether CYP3A4, per se, can activate carcinogens into potent genotoxins, we expressed human CYP3A4 in the DNA-repair mutant (rad4 rad51) strain of budding yeast Saccharomyces cerevisiae and tested the novel, recombinant yeast strain for ability to report CYP3A4-mediated genotoxicity of a well-known genotoxin, aflatoxin B1 (AFB1 )...
May 2017: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/28422300/platelet-reactivity-in-response-to-loading-dose-of-atorvastatin-or-rosuvastatin-in-patients-with-stable-coronary-disease-before-percutaneous-coronary-intervention-the-statiplat-randomized-study
#7
Cosmo Godino, Anna Giulia Pavon, Antonio Mangieri, Anna Salerno, Michela Cera, Alberto Monello, Alaide Chieffo, Valeria Magni, Alberto Cappelletti, Alberto Margonato, Antonio Colombo
BACKGROUND: The acute effects of statin loading dose (LD) on platelet reactivity in patients with chronic stable angina (CSA) are not completely clear. HYPOTHESIS: We hypothesized that LDs of atorvastatin and rosuvastatin have different pharmacodynamic acute effects on platelet aggregability in CSA patients with baseline normal platelet reactivity while on dual antiplatelet therapy (DAPT). METHODS: From September 2011 to February 2014, all consecutive CSA patients on chronic DAPT (aspirin and clopidogrel) were evaluated before elective percutaneous coronary intervention (PCI)...
April 19, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28355945/late-life-depression-modifications-of-brain-resting-state-activity
#8
Filippo Cieri, Roberto Esposito, Nicoletta Cera, Valentina Pieramico, Armando Tartaro, Massimo di Giannantonio
Late-life depression (LLD) is a common emotional and mental disability in the elderly population characterized by the presence of depressed mood, the loss of interest or pleasure in daily activities, and other depression symptoms. It has a serious effect on the quality of life of elderly individuals and increases their risk of developing physical and mental diseases. It is an important area of research, given the growing elderly population. Brain functional connectivity modifications represent one of the neurobiological biomarker for LLD even if to date remains poorly understood...
May 2017: Journal of Geriatric Psychiatry and Neurology
https://www.readbyqxmd.com/read/28346624/association-of-group-prenatal-care-in-us-family-medicine-residencies-with-maternity-care-practice-a-cera-secondary-data-analysis
#9
Wendy B Barr, Sebastian T Tong, Nicholas M LeFevre
BACKGROUND AND OBJECTIVES: Group prenatal care has been shown to improve both maternal and neonatal outcomes. With increasing adaption of group prenatal care by family medicine residencies, this model may serve as a potential method to increase exposure to and interest in maternity care among trainees. This study aims to describe the penetration, regional and program variations, and potential impacts on future maternity care practice of group prenatal care in US family medicine residencies...
March 2017: Family Medicine
https://www.readbyqxmd.com/read/28346619/scope-of-practice-and-family-medicine-match-rates-results-from-a-cera-clerkship-directors-survey
#10
David Anthony, Jordan White, Katherine Margo, Derjung M Tarn
BACKGROUND AND OBJECTIVES: Family medicine clerkship directors depend on community preceptors to teach and attract medical students to family medicine. Many community preceptors do not provide the full range of family medicine services, and some are not family physicians. This study aimed to determine the types of practices in which family medicine clerkship students train and whether scope of practice is associated with family medicine Match rates. METHODS: Data were collected as part of the 2014 Council of Academic Family Medicine Educational Research Alliance (CERA) Family Medicine Clerkship Director Survey...
March 2017: Family Medicine
https://www.readbyqxmd.com/read/28337386/long-term-clinical-outcomes-of-patients-with-rheumatoid-arthritis-and-concomitant-coronary-artery-disease
#11
Marco Spartera, Cosmo Godino, Elena Baldissera, Corrado Campochiaro, Ketty La Spina, Patrizia Aiello, Anna Salerno, Michela Cera, Valeria Magni, Richard J Jabbour, Lorenzo Dagna, Moreno Tresoldi, Alberto Cappelletti, Ottavio Alfieri, Antonio Colombo, Maria Grazia Sabbadini, Alberto Margonato
BACKGROUND: Rheumatoid arthritis (RA) is associated with high morbidity and mortality predominately due to increased cardiovascular risk. Few reports are available regarding the management of coronary artery disease (CAD) in RA patients and the long-term clinical outcomes after coronary revascularization. METHODS AND RESULTS: All consecutive patients with RA were identified by retrospective review at a rheumatology tertiary center in Milan, Italy between 2001 and 2013...
2017: American Journal of Cardiovascular Disease
https://www.readbyqxmd.com/read/28296276/report-on-an-anti-doping-operation-in-guadeloupe-high-number-of-positive-cases-and-inferences-about-doping-habits
#12
A Marchand, C Buisson, L Martin, J-A Martin, A Molina, D Ressiot
Anti-doping controls in non-major events are relatively infrequent and athletes that compete only in these events are less likely to be controlled. The French Anti-Doping Agency carried out an anti-doping operation during a regional cycling competition in Guadeloupe. The urine and serum samples were analysed by the French anti-doping laboratory. Out of 42 athletes, 7 were positive for one or more substances prohibited by the World Anti-Doping Agency. Four serum samples contained continuous erythropoietin receptor activator (CERA) and one a recombinant erythropoietin...
March 11, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28294177/rational-design-of-protein-c-activators
#13
Sergio Barranco-Medina, Mary Murphy, Leslie Pelc, Zhiwei Chen, Enrico Di Cera, Nicola Pozzi
In addition to its procoagulant and proinflammatory functions mediated by cleavage of fibrinogen and PAR1, the trypsin-like protease thrombin activates the anticoagulant protein C in a reaction that requires the cofactor thrombomodulin and the endothelial protein C receptor. Once in the circulation, activated protein C functions as an anticoagulant, anti-inflammatory and regenerative factor. Hence, availability of a protein C activator would afford a therapeutic for patients suffering from thrombotic disorders and a diagnostic tool for monitoring the level of protein C in plasma...
March 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28283091/cyp1a1-i462v-polymorphism-is-associated-with-reduced-genotoxicity-in-yeast-despite-positive-association-with-increased-cancer-risk
#14
Julian Freedland, Cinzia Cera, Michael Fasullo
CYP1A1 functions in detoxifying xenobiotics but occasionally converts compounds into potent genotoxins. CYP1A1 activates polyaromatic hydrocarbons, such as benzo[a]pyrene 7,8 dihydrodiol (BaP-DHD), rendering them genotoxic. Particular alleles of CYP1A1, such as CYP1A1 I462V have been correlated with a higher incidence of breast and lung cancer, but it is unknown whether these variants express enzymes in vivo that are more potent in generating genotoxins. We individually expressed CYP1A1 (CYP1A1.1), CYP1A1 T461N (CYP1A1...
March 2017: Mutation Research
https://www.readbyqxmd.com/read/28261401/training-family-medicine-residents-to-perform-home-visits-a-cera-survey
#15
Tomoko Sairenji, Stephen A Wilson, Frank D'Amico, Lars E Peterson
BACKGROUND : Home visits have been shown to improve quality of care, save money, and improve outcomes. Primary care physicians are in an ideal position to provide these visits; of note, the Accreditation Council for Graduate Medical Education no longer requires home visits as a component of family medicine residency training. OBJECTIVE : To investigate changes in home visit numbers and expectations, attitudes, and approaches to training among family medicine residency program directors...
February 2017: Journal of Graduate Medical Education
https://www.readbyqxmd.com/read/28218936/a-national-cera-study-of-the-use-of-laborists-in-family-medicine-residency-training
#16
Robert A Baldor, Christine Chang Pecci, Gerardo Moreno, Virginia Van Duyne, Stacy E Potts
BACKGROUND AND OBJECTIVES: Little is known about the impact of laborists (which we defined as "clinicians dedicated to providing L&D care services in the hospital environment for pregnant patients, regardless of who provided the prenatal care" for this survey) on family medicine residency training. We surveyed family medicine residency directors to assess characteristics about laborist services and their involvement in family medicine residency teaching. METHODS: Questions were included in the 2015 Council of Academic Family Medicine Educational Research Alliance (CERA) survey of family medicine residency directors...
February 2017: Family Medicine
https://www.readbyqxmd.com/read/28177547/iron-catalyzed-c-h-alkynylation-through-triazole-assistance-expedient-access-to-bioactive-heterocycles
#17
Gianpiero Cera, Tobias Haven, Lutz Ackermann
Triazole assistance enabled the first iron-catalyzed C-H alkynylation of arenes, heteroarenes, and alkenes. The modular TAM directing group set the stage for a sequential C-H alkynylation/annulation strategy with ample scope, enabling the iron-catalyzed assembly of isoquinolones, pyridones, pyrrolones, and isoindolinones with high levels of chemo-, site-, and regioselectivity.
March 13, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28176262/modifications-in-resting-state-functional-anticorrelation-between-default-mode-network-and-dorsal-attention-network-comparison-among-young-adults-healthy-elders-and-mild-cognitive-impairment-patients
#18
Roberto Esposito, Filippo Cieri, Piero Chiacchiaretta, Nicoletta Cera, Mariella Lauriola, Massimo Di Giannantonio, Armando Tartaro, Antonio Ferretti
Resting state brain activity incorporates different components, including the Default Mode Network and the Dorsal Attention Network, also known as task-negative network and task-positive network respectively. These two networks typically show an anticorrelated activity during both spontaneous oscillations and task execution. However modifications of this anticorrelated activity pattern with age and pathology are still unclear. The present study aimed to investigate differences in resting state Default Mode Network-Dorsal Attention Network functional anticorrelation among young adults, healthy elders and Mild Cognitive Impairment patients...
February 7, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28044985/radiation-dose-absorbed-by-operators-during-transradial-percutaneous-coronary-procedures-comparing-different-protective-drapes-the-radiation-study
#19
Alessandro Sciahbasi, Stefano Rigattieri, Alessandro Sarandrea, Maria Cera, Cristian Di Russo, Silvio Fedele, Silvio Romano, Francesco Rocco Pugliese, Maria Penco
AIMS: To compare different radiation protection drapes in term of radiation dose absorbed by operators during right or left transradial procedures. METHODS AND RESULTS: Patients who underwent transradial coronary procedures were randomized initially in 4 groups: Group 1 (no drapes), Group 2 (drape on patient's arm), Group 3 (pelvic drape), Group 4 (combined arm and pelvic drapes). Subsequently each group was further randomized to right or left radial access. The primary end-point was the operator radiation dose at thorax...
January 3, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28004857/polywhips-directional-particle-transport-by-gradient-directed-growth-and-stiffening-of-supramolecular-assemblies
#20
Luca Cera, Leonardo Chiappisi, Christoph Böttcher, Andrea Schulz, Stefan Schoder, Michael Gradzielski, Christoph A Schalley
Growth of rigid rods occurs via supramolecular assembly of a nonconjugated π-donor π-acceptor monomer and is triggered by a NaCl gradient. The mechanical stiffness of this material is controlled by the local salt concentration and is ion specific. The continuous and well-controlled growth process is exploited to power the directional transport of sub-millimeter polymer particles.
February 2017: Advanced Materials
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