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https://www.readbyqxmd.com/read/28044985/radiation-dose-absorbed-by-operators-during-transradial-percutaneous-coronary-procedures-comparing-different-protective-drapes-the-radiation-study
#1
Alessandro Sciahbasi, Stefano Rigattieri, Alessandro Sarandrea, Maria Cera, Cristian Di Russo, Silvio Fedele, Silvio Romano, Francesco Rocco Pugliese, Maria Penco
AIMS: To compare different radiation protection drapes in term of radiation dose absorbed by operators during right or left transradial procedures. METHODS AND RESULTS: Patients who underwent transradial coronary procedures were randomized initially in 4 groups: Group 1 (no drapes), Group 2 (drape on patient's arm), Group 3 (pelvic drape), Group 4 (combined arm and pelvic drapes). Subsequently each group was further randomized to right or left radial access. The primary end-point was the operator radiation dose at thorax...
January 3, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28004857/polywhips-directional-particle-transport-by-gradient-directed-growth-and-stiffening-of-supramolecular-assemblies
#2
Luca Cera, Leonardo Chiappisi, Christoph Böttcher, Andrea Schulz, Stefan Schoder, Michael Gradzielski, Christoph A Schalley
Growth of rigid rods occurs via supramolecular assembly of a nonconjugated π-donor π-acceptor monomer and is triggered by a NaCl gradient. The mechanical stiffness of this material is controlled by the local salt concentration and is ion specific. The continuous and well-controlled growth process is exploited to power the directional transport of submillimeter polymer particles.
December 22, 2016: Advanced Materials
https://www.readbyqxmd.com/read/27990008/anemia-treatment-by-erythropoiesis-stimulating-agents-during-the-6-months-before-initiation-of-hemodialysis-comparison-between-darbepoetin-alfa-and-continuous-erythropoietin-receptor-activator
#3
Tadashi Yoshida, Matsuhiko Hayashi
Anemia in chronic kidney disease (CKD) is a risk factor for cardiovascular diseases and is treated by long-acting erythropoiesis-stimulating agents (ESA). Although results of previous studies showed that the hemoglobin level could not be maintained at initiation of dialysis in CKD patients treated with recombinant human erythropoietin, it remains undetermined if long-acting ESA are effective to prevent the progression of anemia at initiation of dialysis. In the present study, hemoglobin levels in 40 CKD patients treated with darbepoetin alfa (DA) and 15 CKD patients treated with a continuous erythropoietin receptor activator (CERA) were retrospectively compared during the 6 months period prior to initiation of dialysis...
December 19, 2016: Keio Journal of Medicine
https://www.readbyqxmd.com/read/27969897/tct-531-intracoronary-vs-intravenous-adenosine-for-fractional-flow-reserve-measurement-a-meta-analysis
#4
Stefano Rigattieri, Giuseppe Biondi-Zoccai, Alessandro Sciahbasi, Cristian Di RUsso, Maria Cera, Jonathan Beaudoin, Silvio Fedele, Francesco Pugliese
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27965501/effect-of-surface-treatments-on-the-bond-strength-to-turkom-cera-all-ceramic-material
#5
Abdul Aa Razak, Mohamed I Abu-Hassan, Bandar Ma Al-Makramani, Fuad A Al-Sanabani, Ibrahim Z Al-Shami, Hosain M Almansour
AIM: The aim of this study was to evaluate the effect of surface treatments on shear bond strength (SBS) of Turkom-Cera (Turkom-Ceramic (M) Sdn. Bhd., Puchong, Malaysia) all-ceramic material cemented with resin cement Panavia-F (Kuraray Medical Inc., Okayama, Japan). MATERIALS AND METHODS: Forty Turkom-Cera ceramic disks (10 mm × 3 mm) were prepared and randomly divided into four groups. The disks were wet ground to 1000-grit and subjected to four surface treatments: (1) No treatment (Control), (2) sandblasting, (3) silane application, and (4) sandblasting + silane...
November 1, 2016: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/27897969/satb2-determines-mirna-expression-and-long-term-memory-in-the-adult-central-nervous-system
#6
Clemens Jaitner, Chethan Reddy, Andreas Abentung, Nigel Whittle, Dietmar Rieder, Andrea Delekate, Martin Korte, Gaurav Jain, Andre Fischer, Farahnaz Sananbenesi, Isabella Cera, Nicolas Singewald, Georg Dechant, Galina Apostolova
SATB2 is a risk locus for schizophrenia and encodes a DNA-binding protein that regulates higher-order chromatin configuration. In the adult brain Satb2 is almost exclusively expressed in pyramidal neurons of two brain regions important for memory formation, the cerebral cortex and the CA1-hippocampal field. Here we show that Satb2 is required for key hippocampal functions since deletion of Satb2 from the adult mouse forebrain prevents the stabilization of synaptic long-term potentiation and markedly impairs long-term fear and object discrimination memory...
November 29, 2016: ELife
https://www.readbyqxmd.com/read/27871009/malignant-nerve-sheath-tumor-involving-glossopharyngeal-vagus-and-spinal-nerve-with-intracranial-extracranial-extension-and-systemic-metastases-in-a-patient-with-type-1-neurofibromatosis-a-case-report
#7
José Raúl Guerra-Mora, Juan D Del Castillo-Calcáneo, María Elena Córdoba-Mosqueda, Jorge Yáñez-Castro, Ulises García-González, Eduardo Soriano-Navarro, Leticia Llamas-Ceras, Rosa María Vicuña-González
INTRODUCTION: Intracranial malignant peripheral nerve sheath tumors are an extremely rare pathology with a high morbidity and mortality. Epidemiological, clinical and prognostic data are scarce and with little certainty in the literature. The aim of this paper is to report for first time in English literature, the case of a patient with type 1 neurofibromatosis, who presented a malignant peripheral nerve sheath tumor that involved the left glossopharyngeal, vagus and spinal nerves with intracranial and extracranial extension through jugular foramen and systemic metastases...
2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27859873/impact-of-an-intervention-on-the-prescription-of-aliskiren-after-new-evidence-on-safety-reported
#8
Isabel Rosich Martí, Alejandro Allepuz, Gemma Rodriguez Palomar, Francesca Ortin Font, Maria Soler Cera
PURPOSE: The purpose of the study is to analyze the impact of an intervention to disseminate safety alerts on the utilization of Aliskiren added to angiotensin converting enzyme inhibitor (ACEI) or an angiotensin-receptor blocker (ARB). METHODS: Quasi-experimental design (non-randomized intervention) comparing the utilization of Aliskiren + ACEI or ARB in a primary care area-intervention (PCA-I) with a primary care area-control (PCA-C) following a safety alert...
November 16, 2016: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/27832479/large-single-centre-experience-with-the-cera%C3%A2-and-ceraflex%C3%A2-occluders-for-closure-of-interatrial-communications-usefulness-of-the-flexible-rotation-feature
#9
Sotiria C Apostolopoulou, Alexandros Tsoutsinos, Cleo Laskari, Maria Kiaffas, Spyridon Rammos
We present our experience with the Cera (CO) and the CeraFlex occluder (CFO) in transcatheter closure of interatrial communications (IAC). Between 2013 and 2016, 201 patients (75 males, 16 with patent foramen ovale), aged 27 ± 19 (5-75) years, underwent percutaneous closure of IAC using CO or CFO in our institution. After transoesophageal imaging, the procedure was aborted in 7 young paediatric (6-13 years old) patients (3 multiple holes, 3 too small septum, 1 leak with 38 mm occlusion balloon). The occluder was removed prior to release in 11 patients (5...
November 10, 2016: Cardiovascular Intervention and Therapeutics
https://www.readbyqxmd.com/read/27734319/effects-of-selenium-on-short-term-control-of-hyperthyroidism-due-to-graves-disease-treated-with-methimazole-results-of-a-randomized-clinical-trial
#10
M Leo, L Bartalena, G Rotondo Dottore, E Piantanida, P Premoli, I Ionni, M Di Cera, E Masiello, L Sassi, M L Tanda, F Latrofa, P Vitti, C Marcocci, M Marinò
OBJECTIVE: In spite of previous conflicting results, an adjuvant role of selenium in the treatment of Graves' disease (GD) hyperthyroidism has been proposed. To address this issue, a randomized clinical trial was carried out aimed at investigating whether selenium is beneficial on the short-term control of GD hyperthyroidism treated with methimazole (MMI). METHODS: Thirty newly diagnosed hyperthyroid GD patients were randomly assigned to treatment with: (i) MMI or (ii) MMI plus selenium...
October 12, 2016: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/27700073/iterative-synthesis-of-oligo-n-rotaxanes-in-excellent-yield
#11
James E M Lewis, Joby Winn, Luca Cera, Stephen M Goldup
We present an operationally simple iterative coupling strategy for the synthesis of oligomeric homo- and hetero[n]rotaxanes with precise control over the position of each macrocycle. The exceptional yield of the AT-CuAAC reaction, combined with optimized conditions that allow the rapid synthesis of the target oligomers, opens the door to the study of precision-engineered oligomeric interlocked molecules.
December 21, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27642757/costimulatory-effects-of-an-immunodominant-parasite-antigen-paradoxically-prevent-induction-of-optimal-cd8-t-cell-protective-immunity
#12
Christopher S Eickhoff, Xiuli Zhang, Jose R Vasconcelos, R Geoffrey Motz, Nicole L Sullivan, Kelly O'Shea, Nicola Pozzi, David W Gohara, Jennifer R Blase, Enrico Di Cera, Daniel F Hoft
Trypanosoma cruzi infection is controlled but not eliminated by host immunity. The T. cruzi trans-sialidase (TS) gene superfamily encodes immunodominant protective antigens, but expression of altered peptide ligands by different TS genes has been hypothesized to promote immunoevasion. We molecularly defined TS epitopes to determine their importance for protection versus parasite persistence. Peptide-pulsed dendritic cell vaccination experiments demonstrated that one pair of immunodominant CD4+ and CD8+ TS peptides alone can induce protective immunity (100% survival post-lethal parasite challenge)...
September 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27634934/regulation-of-head-and-neck-squamous-cancer-stem-cells-by-pi3k-and-sox2
#13
Stephen B Keysar, Phuong N Le, Bettina Miller, Brian C Jackson, Justin R Eagles, Cera Nieto, Jihye Kim, Binwu Tang, Magdalena J Glogowska, J Jason Morton, Nuria Padilla-Just, Karina Gomez, Emily Warnock, Julie Reisinger, John J Arcaroli, Wells A Messersmith, Lalage M Wakefield, Dexiang Gao, Aik-Choon Tan, Hilary Serracino, Vasilis Vasiliou, Dennis R Roop, Xiao-Jing Wang, Antonio Jimeno
BACKGROUND: We have an incomplete understanding of the differences between cancer stem cells (CSCs) in human papillomavirus-positive (HPV-positive) and -negative (HPV-negative) head and neck squamous cell cancer (HNSCC). The PI3K pathway has the most frequent activating genetic events in HNSCC (especially HPV-positive driven), but the differential signaling between CSCs and non-CSCs is also unknown. METHODS: We addressed these unresolved questions using CSCs identified from 10 HNSCC patient-derived xenografts (PDXs)...
January 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/27624125/thrombin-cleavage-of-plasmodium-falciparum-erythrocyte-membrane-protein-1-inhibits-cytoadherence
#14
Mark R Gillrie, Bernard Renaux, Eleanor Russell-Goldman, Marion Avril, Andrew J Brazier, Koichiro Mihara, Enrico Di Cera, Danny A Milner, Morley D Hollenberg, Joseph D Smith, May Ho
UNLABELLED: Plasmodium falciparum malaria remains one of the most deadly infections worldwide. The pathogenesis of the infection results from the sequestration of infected erythrocytes (IRBC) in vital organs, including the brain, with resulting impairment of blood flow, hypoxia, and lactic acidosis. Sequestration occurs through the adhesion of IRBC to host receptors on microvascular endothelium by Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1), a large family of variant surface antigens, each with up to seven extracellular domains that can bind to multiple host receptors...
September 13, 2016: MBio
https://www.readbyqxmd.com/read/27613791/implementation-of-technology-based-patient-engagement-strategies-within-practice-based-research-networks
#15
Beth Careyva, Kyle Shaak, Geoffrey Mills, Melanie Johnson, Samantha Goodrich, Brian Stello, Lorraine S Wallace
BACKGROUND: Technology-based patient engagement strategies (such as patient portals) are increasingly available, yet little is known about current use and barriers within practice-based research networks (PBRNs). PBRN directors have unique opportunities to inform the implementation of patient-facing technology and to translate these findings into practice. METHODS: PBRN directors were queried regarding technology-based patient engagement strategies as part of the 2015 CAFM Educational Research Alliance (CERA) survey of PBRN directors...
September 2016: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/27573499/iron-catalyzed-c-h-functionalization-processes
#16
REVIEW
Gianpiero Cera, Lutz Ackermann
Iron-catalyzed C-H activation has recently emerged as an increasingly powerful tool for the step-economical transformation of unreactive C-H bonds. Particularly, the recent development of low-valent iron catalysis has set the stage for novel C-H activation strategies via chelation assistance. The low-cost, natural abundance, and low toxicity of iron prompted its very recent application in organometallic C-H activation catalysis. An overview of the use of iron catalysis in C-H activation processes is summarized herein up to May 2016...
October 2016: Topics in Current Chemistry (Journal)
https://www.readbyqxmd.com/read/27516704/qairooti-cerate-or-cera-beeswax-salve-in-traditional-iranian-pharmacy
#17
Ghazaleh Mosleh, Parmis Badr
BACKGROUND: Qairooti (Cerate), a medicinal salve or ointment, compounded of wax and oil, is a formulation used alone or as a basis for medicinal dosage forms. It is widely used from the ancient times to the present. Based on its structure, beeswax has unique characteristics. It builds stable emulsions and increases water absorbance of creams and ointments. The aim of this study was to gather all pharmaceutical information about preparing Qairooti products from traditional pharmacopoeaes, such as the various types of Qairooti and their preparation methods...
May 2016: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/27472790/global-health-in-family-medicine-residency-programs-a-nationwide-survey-of-us-residency-directors-a-cera-study
#18
Ruben Hernandez, Javier F Sevilla Martir, Daniel J Van Durme, Meredith J Faller, Sabrina Yong-Yow, M Kelly Davies, Morhaf Al Achkar
BACKGROUND AND OBJECTIVES: Interest in global health (GH) has increased significantly among medical trainees in the past 3 decades. Despite the potential for family medicine to be a major contributor to GH, there are no recent, large-scale studies of GH education and experiences in family medicine training. This study was designed to assess current opportunities, educational activities, resident interest, perceived program benefits, and barriers to international and domestic GH training in US family medicine residencies...
July 2016: Family Medicine
https://www.readbyqxmd.com/read/27462078/molecular-mechanisms-of-enzyme-activation-by-monovalent-cations
#19
REVIEW
David W Gohara, Enrico Di Cera
Regulation of enzymes through metal ion complexation is widespread in biology and underscores a physiological need for stability and high catalytic activity that likely predated proteins in the RNA world. In addition to divalent metals such as Ca(2+), Mg(2+), and Zn(2+), monovalent cations often function as efficient and selective promoters of catalysis. Advances in structural biology unravel a rich repertoire of molecular mechanisms for enzyme activation by Na(+) and K(+) Strategies range from short-range effects mediated by direct participation in substrate binding, to more distributed effects that propagate long-range to catalytic residues...
September 30, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27456523/chronic-treatment-with-an-erythropoietin-receptor-ligand-prevents-chronic-kidney-disease-induced-enlargement-of-myocardial-infarct-size
#20
Keitaro Nishizawa, Toshiyuki Yano, Masaya Tanno, Takayuki Miki, Atsushi Kuno, Toshiyuki Tobisawa, Makoto Ogasawara, Shingo Muratsubaki, Kouhei Ohno, Satoko Ishikawa, Tetsuji Miura
Chronic kidney disease (CKD) is known to increase myocardial infarct size after ischemia/reperfusion. However, a strategy to prevent the CKD-induced myocardial susceptibility to ischemia/reperfusion injury has not been developed. Here, we examined whether epoetin β pegol, a continuous erythropoietin receptor activator (CERA), normalizes myocardial susceptibility to ischemia/reperfusion injury by its effects on protective signaling and metabolomes in CKD. CKD was induced by 5/6 nephrectomy in rats (subtotal nephrectomy, SNx), whereas sham-operated rats served controls (Sham)...
September 2016: Hypertension
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