keyword
MENU ▼
Read by QxMD icon Read
search

Cera

keyword
https://www.readbyqxmd.com/read/29131493/gaming-to-improve-vision-21-st-century-self-monitoring-for-patients-with-age-related-macular-degeneration
#1
Hessom Razavi, Elizabeth Baglin, Pyrawy Sharangan, Emily Caruso, Nicole Tindill, Susan Griffin, Robyn Guymer
IMPORTANCE: Improved vision self-monitoring tools are required for people at risk of neovascular complications from age related macular degeneration (AMD). BACKGROUND: To report the self-monitoring habits of participants with intermediate AMD using the Amsler grid chart, and the use of personal electronic devices and gameplay in this over 50 year old cohort. DESIGN: Single-centre descriptive study carried out at the Centre for Eye Research (CERA), Melbourne, Australia...
November 13, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/29101622/the-structure-of-cnidosacs-in-nudibranch-mollusc-aeolidia-papillosa-linnaeus-1761-and-presumable-mechanism-of-nematocysts-release
#2
O A Vorobyeva, I A Ekimova, V V Malakhov
The structure of cnidosacs in nudibranch mollusc Aeolidida papillosa (Linnaeus, 1761) before and after the discharging of kleptocnidae has been studied. In the apical zone of the cnidosac, the basal laminae of epidermis and gastrodermis are interrupted, and the muscle layers of the cnidosac and the epidermis are absent. We suggest the formation of a temporary channel during the discharging of the cnidosac. Through this channel, nematocysts move from the cnidosac to the cnidopore, which forms on the top of the ceras...
September 2017: Doklady Biological Sciences: Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections
https://www.readbyqxmd.com/read/29047386/epoetin-%C3%AE-pegol-continuous-erythropoietin-receptor-activator-cera-is-another-choice-for-the-treatment-of-anemia-in-myelodysplastic-syndrome-a-case-report
#3
Tatsuyoshi Ikenoue, Hiroshi Naito, Tetsuya Kitamura, Hideki Hattori
BACKGROUND: In most patients, anemia is present when myelodysplastic syndrome is diagnosed. Although darbepoetin α is the first-choice supportive therapy for low-risk myelodysplastic syndrome, half of all patients develop a loss of response to darbepoetin α within 12 months. However, few reports have described supportive therapy after the loss of response to darbepoetin α. CASE PRESENTATION: We herein present a case involving a 65-year-old Japanese woman with low-risk myelodysplastic syndrome whose erythropoiesis-stimulating agent treatment was switched from darbepoetin α to epoetin β pegol (continuous erythropoietin receptor activator) to treat transfusion-dependent anemia...
October 19, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29045987/perspectives-of-family-medicine-clerkship-directors-regarding-forward-feeding-a-cera-study
#4
Lisa D Mims, Alexei O DeCastro, Ann G Kelly
BACKGROUND AND OBJECTIVES: Forward feeding signifies sharing information about learners for purposes of professional and academic advancement, and promotes progression toward a competency-based educational continuum. The aim of this study is to assess reasons for difficulty or failure of the family medicine clerkship and investigate utilization and methods of forward feeding. Reasons behind medical school policies regarding forward feeding are also evaluated. METHODS: Data were collected through the 2013 Council of Academic Family Medicine (CAFM) Educational Research Alliance (CERA) Family Medicine Clerkship Director survey...
October 2017: Family Medicine
https://www.readbyqxmd.com/read/28975383/intrinsic-thermodynamics-of-high-affinity-inhibitor-binding-to-recombinant-human-carbonic-anhydrase-iv
#5
Aurelija Mickevičiūtė, David D Timm, Marius Gedgaudas, Vaida Linkuvienė, Zhiwei Chen, Abdul Waheed, Vilma Michailovienė, Asta Zubrienė, Alexey Smirnov, Edita Čapkauskaitė, Lina Baranauskienė, Jelena Jachno, Jurgita Revuckienė, Elena Manakova, Saulius Gražulis, Jurgita Matulienė, Enrico Di Cera, William S Sly, Daumantas Matulis
Membrane-associated carbonic anhydrase (CA) isoform IV participates in carbon metabolism and pH homeostasis and is implicated in the development of eye diseases such as retinitis pigmentosa and glaucoma. A series of substituted benzenesulfonamides were designed and their binding affinity to CA IV was determined by fluorescent thermal shift assay and isothermal titration calorimetry (ITC). Compound [(4-chloro-2-phenylsulfanyl-5-sulfamoyl-benzoyl)amino]propyl acetate (19) bound CA IV with the K d of 1.0 nM and exhibited significant selectivity over the remaining 11 human CA isoforms...
October 3, 2017: European Biophysics Journal: EBJ
https://www.readbyqxmd.com/read/28953370/competitive-transmetalation-of-first-row-transition-metal-ions-between-trinuclear-triple-stranded-side-by-side-helicates
#6
Barun Jana, Luca Cera, Bidyut Akhuli, Sourenjit Naskar, Christoph A Schalley, Pradyut Ghosh
A hybrid tris-bidentate neutral ligand (L) composed of a central 2,2'-bipyridine and two terminal triazolyl-pyridine chelating units connected by methylene spacers is employed to synthesize trinuclear triple-stranded side-by-side helicates of first-row transition-metal(II) ions. Three such new homometallic helicates L3M3(OTf)6 [ M = Cu(2+) (4); Ni(2+) (5); Co(2+) (6)], along with our recently reported helicates L3Fe3(OTf)6 (1), L3Zn3(OTf)6 (2), and L3Fe2Zn(OTf)6 (3) are taken into consideration for competitive formation and transmetalation studies...
September 27, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28953291/family-physicians-and-provision-of-immediate-postpartum-contraception-a-cera-study
#7
Michelle H Moniz, Anna K McEvoy, Michelle Hofmeister, Missy Plegue, Tammy Chang
BACKGROUND AND OBJECTIVES: The Centers for Disease Control and Prevention (CDC) support the provision of intrauterine devices (IUDs) and the contraceptive implant to women immediately after childbirth. We aimed to assess perceived training needs and barriers to immediate postpartum contraceptive service delivery among US family physicians. METHODS: We contributed items regarding postpartum contraception to the 2015 Council of Academic Family Medicine Educational Research Alliance (CERA) omnibus survey of a national cohort of family medicine educators...
September 2017: Family Medicine
https://www.readbyqxmd.com/read/28941809/lc-hrms-based-metabolomic-approach-for-the-detection-of-cera-s-effects-in-horse-doping-control
#8
Céline Joré, Benoît Loup, Patrice Garcia, Anne-Christelle Paris, Marie-Agnès Popot, Michel Audran, Yves Bonnaire, Emmanuelle Varlet-Marie, Ludovic Bailly-Chouriberry
Erythropoiesis Stimulating Agents (ESAs) were developed for therapeutic purposes to stimulate red blood cell (RBC) production. Consequently, tissue oxygenation is enhanced as athlete's endurance and ESAs misuse now benefits doping. Our hypothesis is that most of ESAs should have similar mechanisms and thus have the same effects on metabolism. Studying the metabolome variations could allow suspecting the use of any ESAs with a single method by targeting their effects. In this objective, a metabolomic study was carried out on 3 thoroughbred horses with a single administration of 4...
September 14, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28941613/sibpa-under-the-tuscan-sun-introduction-to-the-sibpa-xxiii-special-issue
#9
EDITORIAL
Daniela Giacomazza, Cristiano Viappiani, Enrico Di Cera, Carlo Musio
The Italian Society for Pure and Applied Biophysics (SIBPA) held its XXIII National Congress in the gorgeous Tuscan town of Cortona, Italy, on September 18-21, 2016. This special issue features a selection of contributions from the Congress in the areas of molecular, applied, cellular and computational biophysics. Cutting-edge developments in nanoscale biophysics were introduced for the first time in the program. SIBPA continues its successful promotion of biophysical disciplines at the national and international levels, with added strength from its partnership with Biophysical Chemistry and Elsevier...
October 2017: Biophysical Chemistry
https://www.readbyqxmd.com/read/28782299/continuous-erythropoiesis-receptor-activator-cera-for-the-anaemia-of-chronic-kidney-disease
#10
REVIEW
Valeria M Saglimbene, Suetonia C Palmer, Marinella Ruospo, Patrizia Natale, Jonathan C Craig, Giovanni Fm Strippoli
BACKGROUND: Continuous erythropoiesis receptor activator (CERA) is a newer, longer acting ESA which might be preferred to other ESAs (epoetin or darbepoetin) based on its lower frequency of administration. Different dosing requirements and molecular characteristics of CERA compared with other ESAs may lead to different health outcomes (mortality, cardiovascular events, quality of life) in people with anaemia and chronic kidney disease (CKD). OBJECTIVES: To assess benefits and harms of CERA compared with other epoetins (darbepoetin alfa and epoetin alfa or beta) or placebo/no treatment or CERA with differing strategy of administration for anaemia in individuals with CKD...
August 7, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28724151/assessment-of-addiction-medicine-training-in-family-medicine-residency-programs-a-cera-study
#11
Sebastian Tong, Roy Sabo, Rebecca Aycock, Ramakrishna Prasad, Rebecca Etz, Anton Kuzel, Alex Krist
BACKGROUND AND OBJECTIVES: Substance use disorder (SUD) is a widespread problem but physicians may feel inadequately prepared to provide addiction care. We sought to assess current addiction medicine curricula in US family medicine residencies (FMRs) and evaluate barriers to improving or implementing addiction medicine curricula. METHODS: Questions regarding addiction medicine training were added to the December 2015 Council of Academic Family Medicine Educational Research Alliance (CERA) survey to US FMR program directors to evaluate each FMR's curriculum, potential workforce production, perceived barriers to improving or implementing curricula and faculty training in addiction medicine...
July 2017: Family Medicine
https://www.readbyqxmd.com/read/28722470/novel-potent-inhibitors-of-the-histone-demethylase-kdm1a-lsd1-orally-active-in-a-murine-promyelocitic-leukemia-model
#12
Paolo Trifirò, Anna Cappa, Silvia Brambillasca, Oronza A Botrugno, Maria Rosaria Cera, Roberto Dal Zuffo, Paola Dessanti, Giuseppe Meroni, Florian Thaler, Manuela Villa, Saverio Minucci, Ciro Mercurio, Mario Varasi, Paola Vianello
BACKGROUND: Histone lysine demethylases (KDMs) are well-recognized targets in oncology drug discovery. They function at the post-translation level controlling chromatin conformation and gene transcription. KDM1A is a flavin adenine dinucleotide-dependent amine oxidase, overexpressed in several tumor types, including acute myeloid leukemia, neuroblastoma and non-small-cell lung cancer. Among the many known monoamine oxidase inhibitors screened for KDM1A inhibition, tranylcypromine emerged as a moderately active hit, which irreversibly binds to the flavin adenine dinucleotide cofactor...
July 2017: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/28721817/improvement-of-thermosensitive-liposome-stability-by-cerasome-forming-lipid-with-si-o-si-network-structure
#13
Qin Su, Ximing Pu, He Bai, Xianchun Chen, Xiaoming Liao, Zhongbing Huang, Guangfu Yin
BACKGROUND: Liposomes have been widely used in the gene transfection and the drug delivery systems due to their excellent biocompatibility and encapsulation ability, especially, the ability to deliver the gene/drug into the cells via the membrane fusion. Thermosensitive liposoems have been proven to be a precise and effective method for cancer treatment in many preclinical studies. But the imperfect crystalline arrangement between grains occurred, resulting in planar defects at the boundaries of membranes, compromising the stability of thermosensitive liposomes...
July 19, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28704583/mncl2-catalyzed-c-h-alkylations-with-alkyl-halides
#14
Weiping Liu, Gianpiero Cera, João C A Oliveira, Zhigao Shen, Lutz Ackermann
C-H alkylations with challenging β-hydrogen-containing alkyl halides were accomplished with sustainable MnCl2 as the catalyst under phosphine-ligand-free conditions. The proximity-induced benzamide C-H activation occurred with ample substrate scope through rate-determining C-H metalation, also setting the stage for manganese-catalyzed oxidative C-H methylations.
July 13, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28686458/tri-substituted-triazole-enabled-c-h-activation-of-benzyl-and-aryl-amines-by-iron-catalysis
#15
Zhigao Shen, Gianpiero Cera, Tobias Haven, Lutz Ackermann
The design of trisubstituted triazoles set the stage for proximity-induced iron-catalyzed C-H activation of benzyl and aryl amines with ample scope. Thereby, C-H alkylations and C-H arylations proved viable with high levels of chemo and positional selectivities by means of racemization-free iron catalysis with the reusable triazole being removed in a traceless fashion.
July 7, 2017: Organic Letters
https://www.readbyqxmd.com/read/28651849/meta-analysis-of-head-to-head-comparison-of-intracoronary-versus-intravenous-adenosine-for-the-assessment-of-fractional-flow-reserve
#16
REVIEW
Stefano Rigattieri, Giuseppe Biondi Zoccai, Alessandro Sciahbasi, Cristian Di Russo, Maria Cera, Roberto Patrizi, Silvio Fedele, Andrea Berni, Francesco Rocco Pugliese
Intravenous (IV) infusion of adenosine represents the gold standard for measuring fractional flow reserve (FFR). However, IV adenosine is more expensive and time-consuming compared with intracoronary (IC) boluses of adenosine. We conducted a meta-analysis of studies comparing IC with IV adenosine for FFR assessment in the same coronary lesions. We searched for studies comparing IC with IV adenosine and reporting absolute FFR values or rate of abnormal FFR for both routes. Prespecified subgroup analysis was performed to appraise studies using low-dose (<100 μg) or high-dose IC adenosine (≥100 μg)...
August 15, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28648428/transcatheter-closure-of-left-ventricle-to-right-atrial-communication-using-cera-duct-occluder
#17
Gnanavelu Ganesan, G Justin Paul, Vaikom S Mahadevan
Left ventricle-right atrial communication could be congenital (Gerbode defect) or acquired as a complication of surgery or infective endocarditis and leads to volume overloading of pulmonary circulation. Two types, direct and indirect types are known depending on the involvement of septal tricuspid leaflet. Transcatheter closure of this defect is feasible and appears an attractive alternative to surgical management. Various devices like Amplatzer duct occluder I, II, Muscular ventricular septal defect device etc...
May 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28633169/untapped-potential-performance-of-procedural-skills-in-the-family-medicine-clerkship
#18
Martina Kelly, Kelly M Everard, Lara Nixon, Alexander Chessman
BACKGROUND AND OBJECTIVES: While family medicine residency directors have expressed concern about low procedural skills proficiency among incoming residents, curricular recommendations do not provide widely accepted guidance. This study was designed to describe requirements and experiences in procedural skill training during the family medicine clerkship and test the hypothesis that more rural placements may support this training. METHODS: The survey was conducted as part of the CAFM Educational Research Alliance (CERA) Family Medicine Clerkship Director (CD) 2013 survey...
June 2017: Family Medicine
https://www.readbyqxmd.com/read/28632764/accuracy-and-reliability-of-retinal-photo-grading-for-diabetic-retinopathy-remote-graders-from-a-developing-country-and-standard-retinal-photo-grader-in-australia
#19
Fakir M Amirul Islam
BACKGROUND: To evaluate the accuracy and reliability of fundus retinal photos graded by local graders in Bangladesh with those graded by an expert at the Centre for Eye Research Australia (CERA) in the context of mass scale diabetic retinopathy (DR) screening in Bangladesh. METHODS: A population-based cross-sectional study of 3,104 adults identified 213 (7.2%) eligible patients with diabetes of age ≥ 40 years in 2012-2013. Retinal photographs were collected using a non-mydriatic digital fundus retinal camera and a two-field imaging protocol...
2017: PloS One
https://www.readbyqxmd.com/read/28617311/inducible-nitric-oxide-synthase-polymorphisms-and-nitric-oxide-levels-in-individuals-with-chronic-periodontitis
#20
Raquel M Scarel-Caminaga, Flávia F Cera, Suzane C Pigossi, Livia S Finoti, Yeon J Kim, Aline C Viana, Rodrigo Secolin, Marcelo F Montenegro, José E Tanus-Santos, Silvana R P Orrico, Joni A Cirelli
This study aimed to investigate whether the -1026(A>C)(rs2779249) and +2087(A>G)(2297518) polymorphisms in the NOS2 gene were associated with chronic periodontitis (CP) and with salivary levels of nitrite (NO₂(-)) and/or nitrate + nitrite (NOx). A group of 113 mixed-race patients were subjected to periodontal, genetic, and biochemical evaluations (65 CP/48 periodontally healthy subjects). DNA was extracted from oral epithelial cells and used for genotyping by polymerase chain reaction (real-time). Salivary NOx concentrations were determined using an ozone-based chemiluminescence assay...
June 15, 2017: International Journal of Molecular Sciences
keyword
keyword
100938
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"