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https://www.readbyqxmd.com/read/29893627/practices-attitudes-and-beliefs-of-palliative-care-physicians-regarding-the-use-of-methadone-and-other-long-acting-opioids-in-children-with-advanced-cancer
#1
Kevin Madden, Minjeong Park, Diane Liu, Eduardo Bruera
BACKGROUND: Palliative care physicians often assist with pain management in children with cancer, but little is known about how they use long-acting opioids for chronic pain with these patients. OBJECTIVE: To determine the practices, attitudes, and beliefs of palliative care physicians toward the use of long-acting opioids in children with advanced cancer. DESIGN: An electronic survey was sent to all members of The American Academy of Pediatrics (AAP) Section of Hospice and Palliative Medicine (SOHPM) and those identified as physicians who provide palliative care to children on the AAP SOHPM LISTSERV® ...
June 12, 2018: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29892701/the-association-between-nicotine-dependence-and-physical-health-among-people-receiving-injectable-diacetylmorphine-or-hydromorphone-for-the-treatment-of-chronic-opioid-use-disorder
#2
Heather Palis, Kirsten Marchand, Mohammad Karamouzian, Scott MacDonald, Scott Harrison, Daphne Guh, Kurt Lock, Suzanne Brissette, Aslam H Anis, Michael Krausz, David C Marsh, Martin T Schechter, Eugenia Oviedo-Joekes
Introduction: People with chronic opioid use disorder often present to treatment with individual and structural vulnerabilities and remain at risk of reporting adverse health outcomes. This risk is greatly compounded by tobacco smoking, which is highly prevalent among people with chronic opioid use disorder. Despite the known burden of tobacco smoking on health, the relationship between nicotine dependence and health has not been studied among those receiving injectable opioid agonist treatment...
June 2018: Addictive Behaviors Reports
https://www.readbyqxmd.com/read/29886112/postoperative-pain-and-opioid-analgesic-requirements-after-orthognathic-surgery
#3
Ashkan Mobini, Pushkar Mehra, Radhika Chigurupati
PURPOSE: The purpose of this study was to determine the effect of individual characteristics, such as age, gender, and type of surgery, on postoperative pain intensity and opioid analgesic consumption after orthognathic surgery. PATIENTS AND METHODS: This prospective observational study was conducted at a single academic medical center during a 12-month period from 2015 to 2016. Thirty of 125 patients 18 to 65 years of age who had American Society of Anesthesiologists status I and II and were admitted to the hospital after orthognathic surgery were recruited...
May 19, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29849846/patient-controlled-intravenous-analgesia-for-advanced-cancer-patients-with-pain-a-retrospective-series-study
#4
Zhiyou Peng, Yanfeng Zhang, Jianguo Guo, Xuejiao Guo, Zhiying Feng
Objective: To compare the efficacy and side effects of patient-controlled intravenous analgesia (PCIA) with hydromorphone, sufentanil, and oxycodone on the management of advanced cancer patients with pain. Methods: Patients allocated to receive PCIA between January 2015 and December 2016 were chosen for this study. After reviewing medical records, we verified if hydromorphone, sufentanil, or oxycodone for PCIA could equally provide effective pain relief. A numeric rating scale (NRS) of cancer pain was applied before PCIA, at 4 hours after PCIA, and at the discontinuation of PCIA...
2018: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/29847382/intraoperative-methadone-in-same-day-ambulatory-surgery-a-randomized-double-blinded-dose-finding-pilot-study
#5
Helga Komen, L Michael Brunt, Elena Deych, Jane Blood, Evan D Kharasch
BACKGROUND: Approximately 50 million US patients undergo ambulatory surgery annually. Postoperative opioid overprescribing is problematic, yet many patients report inadequate pain relief. In major inpatient surgery, intraoperative single-dose methadone produces better analgesia and reduces opioid use compared with conventional repeated dosing of short-duration opioids. This investigation tested the hypothesis that in same-day ambulatory surgery, intraoperative methadone, compared with short-duration opioids, reduces opioid consumption and pain, and determined an effective intraoperative induction dose of methadone for same-day ambulatory surgery...
May 25, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29801700/opioid-exposure-is-associated-with-nonunion-risk-in-a-traumatically-injured-population-an-inception-cohort-study
#6
Thomas Buchheit, Robert Zura, Zhe Wang, Samir Mehta, Gregory J Della Rocca, R Grant Steen
INTRODUCTION: Certain common medications are associated with an elevated risk of fracture and recent data suggests that medications can also increase nonunion risk. Medication use is a modifiable nonunion risk factor, but it is unknown whether risk accrues solely to chronic medication use or whether there is also risk inherent to acute use. METHODS: Multivariate logistic regression was used in an inception cohort to calculate odds ratios (OR) for fracture nonunion associated with medication use, in context with other risk factors demonstrated to influence nonunion...
May 21, 2018: Injury
https://www.readbyqxmd.com/read/29784079/analgesic-efficacy-and-safety-of-hydromorphone-in-chinchillas-chinchilla-lanigera
#7
Emily A Evenson, Christoph Mans
Limited information is available regarding the efficacy of opioid analgesics in chinchillas. Here we sought to evaluate the analgesic efficacy and safety of hydromorphone in chinchillas. In a randomized, controlled, blind, complete crossover design, hydromorphone was administered at 0.5, 1, and 2 mg/kg SC to 16 chinchillas. Analgesic efficacy was determined by measuring hindlimb withdrawal latencies after a thermal noxious stimulus (Hargreaves method) at 0, 1, 2, 4, and 8 h after drug administration. Changes in daily food intake and fecal output after hydromorphone administration were recorded...
May 1, 2018: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/29730268/thoracic-paravertebral-block-versus-thoracic-epidural-analgesia-for-post-operative-pain-control-in-open-pancreatic-surgery-a-randomized-controlled-trial
#8
Jacob L Hutchins, Anthony J Grandelis, Alexander M Kaizer, Eric H Jensen
STUDY OBJECTIVE: The purpose of this study was to compare the efficacy of bilateral ultrasound guided thoracic paravertebral catheters to a thoracic epidural after open pancreatic surgery. DESIGN: This was a prospective non-blinded randomized controlled trial. SETTING: Academic hospital operating room, postoperative recovery area, and ward. PATIENTS: 53 patients aged 18 and above who had open pancreatic surgery. INTERVENTIONS: Patients received either bilateral thoracic paravertebral block at T8 with an infusion of 0...
May 3, 2018: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/29680394/the-clinical-effects-of-a-low-dose-dexmedetomidine-constant-rate-infusion-in-isoflurane-anesthetized-cats
#9
B T Simon, E M Scallan, C D Coursey, W M Kiehl, E J Moore
The aim of this study was to evaluate the effects of a low dose dexmedetomidine constant rate infusion (CRI) on cardiopulmonary function, inhalant anesthetic concentration and recovery in isoflurane anesthetized cats. In a prospective, randomized, blinded, controlled design, 12 cats undergoing anesthesia for ovariohysterectomy were administered hydromorphone (0.1mg/kg) intramuscularly, propofol (4.3-7.8mg/kg) intravenously and maintained with isoflurane. During isoflurane anesthesia, the cats were administered either a dexmedetomidine loading dose (0...
April 2018: Veterinary Journal
https://www.readbyqxmd.com/read/29673620/effects-of-opioid-and-non-opioid-analgesics-on-responses-to-psychosocial-stress-in-humans
#10
Anya K Bershad, Melissa A Miller, Greg J Norman, Harriet de Wit
Both preclinical and clinical evidence suggests that the endogenous opioid system is involved in responses to stress. For example, in animal models opioid agonists reduce isolation distress whereas opioid antagonists increase isolation distress. We recently reported that the mixed mu agonist and kappa antagonist buprenorphine dampened responses to acute psychosocial stress in humans. Now we extend this to study the effects of a pure mu-opioid agonist, hydromorphone, and a non-opioid analgesic, acetaminophen, on response to social stress...
April 24, 2018: Hormones and Behavior
https://www.readbyqxmd.com/read/29659913/a-randomized-double-blind-non-inferiority-study-of-hydromorphone-hydrochloride-immediate-release-tablets-versus-oxycodone-hydrochloride-immediate-release-powder-for-cancer-pain-efficacy-and-safety-in-japanese-cancer-patients
#11
Satoshi Inoue, Yoji Saito, Satoru Tsuneto, Etsuko Aruga, Hiroshi Takahashi, Mitsutoshi Uemori
Background: Hydromorphone is a standard opioid analgesic for cancer pain that, prior to this study, was not approved in Japan, where options for opioid switching are limited. We aimed to investigate the efficacy and safety of hydromorphone (DS-7113b) immediate-release tablets in opioid-naïve cancer patients with moderate to severe cancer pain. Methods: Multicenter, active-controlled, randomized, double-blind, parallel-group, non-inferiority study of 183 cancer patients over 20 years of age at 50 clinical sites in Japan...
June 1, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29655955/employment-and-paid-work-among-participants-in-a-randomized-controlled-trial-comparing-diacetylmorphine-and-hydromorphone
#12
Mohammadali Nikoo, Marc Vogel, Fiona Choi, Michael J Song, Jensen Burghardt, Zafar Zafari, Katarina Tabi, Anastasia Frank, Skye Barbic, Christian Schütz, Kerry Jang, Michael Krausz
BACKGROUND: Employment is one of the less studied but a significant outcome of medication-assisted treatment. Thus, we aimed to explore employment outcomes of medication-assisted treatment with hydromorphone (HDM) or diacetylmorphine (DAM). The secondary aim was to estimate characteristics of this population as well as treatment-related factors associated with these outcomes. METHODS: This was a secondary analysis of a randomized, double blind controlled trial. A total of 102 and 100 participants were randomized to receive injectable DAM or HDM for 6 months respectively...
July 2018: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29649890/what-parenteral-opioids-to-use-in-face-of-shortages-of-morphine-hydromorphone-and-fentanyl
#13
Mellar P Davis, Mary Lynn McPherson, Zankhana Mehta, Bertrand Behm, Carlos Fernandez
Parenteral potent opioid availability is becoming an issue in acute pain management. Two opioids, nalbuphine and buprenorphine, are available which can be substituted for hydromorphone, fentanyl, and morphine. There are advantages and disadvantages in using these 2 opioids which are discussed, and potential dosing strategies are outlined.
January 1, 2018: American Journal of Hospice & Palliative Care
https://www.readbyqxmd.com/read/29605036/ketamine-versus-hydromorphone-patient-controlled-analgesia-for-acute-pain-in-trauma-patients
#14
Sheila C Takieddine, Christopher A Droege, Neil Ernst, Molly E Droege, Megan Webb, Richard D Branson, Travis W Gerlach, Bryce R H Robinson, Jay A Johannigman, Eric W Mueller
BACKGROUND: It is unknown whether ketamine administered via patient-controlled analgesia (PCA) provides adequate analgesia while reducing opioid consumption in the traumatically injured patient. Differences in opioid consumption, pain scores, and adverse effects between ketamine and hydromorphone PCA were studied. MATERIALS AND METHODS: This is an investigator-initiated, single-center, double-blinded, randomized, pilot trial conducted from 2014 to 2016 at a level 1 trauma center...
May 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29589873/cost-effectiveness-of-hydromorphone-for-severe-opioid-use-disorder-findings-from-the-salome-randomized-clinical-trial
#15
Nick Bansback, Daphne Guh, Eugenia Oviedo-Joekes, Suzanne Brissette, Scott Harrison, Amin Janmohamed, Michael Krausz, Scott MacDonald, David C Marsh, Martin T Schechter, Aslam H Anis
BACKGROUND AND AIMS: Previous research has found diacetylmorphine, delivered under supervision, to be cost-effective in the treatment of severe opioid use disorder, but diacetylmorphine is not available in many settings. The Study to Assess Long-term Opioid Maintenance Effectiveness (SALOME) randomized controlled trial provided evidence that injectable hydromorphone is non-inferior to diacetylmorphine. The current study aimed to compare the cost-effectiveness of hydromorphone directly with diacetylmorphine and indirectly with methadone maintenance treatment...
March 28, 2018: Addiction
https://www.readbyqxmd.com/read/29582394/comparative-rates-of-mortality-and-serious-adverse-effects-among-commonly-prescribed-opioid-analgesics
#16
David L Murphy, Jacob A Lebin, Stevan G Severtson, Heather A Olsen, Nabarun Dasgupta, Richard C Dart
INTRODUCTION: The epidemic of prescription opioid overdose and mortality parallels the dispensing rates of prescription opioids, and the availability of increasingly potent opioid analgesics. OBJECTIVE: The common assumption that more potent opioid analgesics are associated with higher rates of adverse outcomes has not been adequately substantiated. We compared the rate of serious adverse events among commonly prescribed opioid analgesics of varying potency. METHODS: Serious adverse events (SAEs; defined as death, major medical effect, or hospitalization) resulting from exposure to tablets containing seven opioid analgesics (oxycodone, hydrocodone, morphine, hydromorphone, oxymorphone, tapentadol, and tramadol) captured by the Researched Abuse, Diversion and Addiction-Related Surveillance (RADARS® ) System Poison Center Program were evaluated from 2010 through 2016...
March 26, 2018: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/29563006/opioid-rotation-in-cancer-pain-treatment
#17
Michael Schuster, Oliver Bayer, Florian Heid, Rita Laufenberg-Feldmann
BACKGROUND: Rotating several different WHO level III opioid drugs is a therapeutic option for patients with chronic cancer-related pain who suffer from inadequate analgesia and/or intolerable side effects. The evidence favoring opioid rotation is controversial, and the current guidelines in Germany and other countries contain only weak recommendations for it. METHODS: This review is based on pertinent publications retrieved by a systematic review of the literature on opioid rotation for adult patients with chronic cancerrelated pain who are regularly taking WHO level III opioids by the oral or trans - dermal route...
March 2, 2018: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/29554666/iv-prochlorperazine-diphenhydramine-improved-migraine-pain-relief-more-than-iv-hydromorphone-in-the-ed
#18
Alexander W Chessman
No abstract text is available yet for this article.
March 20, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29554298/development-of-a-quantitative-lc-ms-ms-assay-for-codeine-morphine-6-acetylmorphine-hydrocodone-hydromorphone-oxycodone-and-oxymorphone-in-neat-oral-fluid
#19
Megan Grabenauer, Katherine N Moore, Nichole D Bynum, Robert M White, John M Mitchell, Eugene D Hayes, Ronald Flegel
Recent advances in analytical capabilities allowing for the identification and quantification of drugs and metabolites in small volumes at low concentrations have made oral fluid a viable matrix for drug testing. Oral fluid is an attractive matrix option due to its relative ease of collection, reduced privacy concerns for observed collections and difficulty to adulterate. The work presented here details the development and validation of a liquid chromatography tandem mass spectrometry (LC-MS-MS) method for the quantification of codeine, morphine, 6-acetylmorphine, hydrocodone, hydromorphone, oxycodone and oxymorphone in neat oral fluid...
March 15, 2018: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/29516486/opioid-induced-likeability-and-feeling-good-are-not-associated-with-return-visits-to-an-ed-among-migraine-patients-administered-iv-hydromorphone
#20
Benjamin W Friedman, Alexander Latev, Caron Campbell, Deborah White
BACKGROUND: Parenteral opioids are used in more than 50% of emergency department (ED) visits for migraine. Use of opioids for migraine has been associated with subsequent ED visits, perhaps because of opioid-induced euphoria. In this study, we quantify the extent to which nontherapeutic effects of opioids influence migraine outcomes. We hypothesized that "feeling good" and medication likeability would in fact be associated with receipt of opioids (rather than relief of migraine pain) and that receipt of opioids (rather than relief of migraine pain) would be associated with return visits to the ED...
March 8, 2018: Headache
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