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https://www.readbyqxmd.com/read/27907012/the-signature-of-microrna-dysregulation-in-muscle-paralyzed-by-spinal-cord-injury-includes-downregulation-of-micrornas-that-target-myostatin-signaling
#1
Rita De Gasperi, Zachary A Graham, Lauren M Harlow, William A Bauman, Weiping Qin, Christopher P Cardozo
Spinal cord injury (SCI) results in muscle atrophy, reduced force generation and an oxidative-to-glycolytic fiber type shift. The mechanisms responsible for these alterations remain incompletely understood. To gain new insights regarding mechanisms involved in deterioration of muscle after SCI, global expression profiles of miRs in paralyzed gastrocnemius muscle were compared between sham-operated (Sham) and spinal cord-transected (SCI) rats. Ingenuity Pathways Analysis of the altered miRs identified signaling via insulin, IGF-1, integrins and TGF-β as being significantly enriched for target genes...
2016: PloS One
https://www.readbyqxmd.com/read/27889473/endothelial-cells-regulate-%C3%AE-catenin-activity-in-adrenocortical-cells-via-secretion-of-basic-fibroblast-growth-factor
#2
Carolin Schwafertz, Sven Schinner, Markus C Kühn, Matthias Haase, Amelie Asmus, Birgit Mülders-Opgenoorth, Ishrath Ansurudeen, Peter J Hornsby, Henning Morawietz, Elke Oetjen, Matthias Schott, Holger S Willenberg
Endothelial cell-derived products influence the synthesis of aldosterone and cortisol in human adrenocortical cells by modulating proteins such as steroidogenic acute-regulatory (StAR) protein, steroidogenic factor (SF)-1 and CITED2. However, the potential endothelial cell-derived factors that mediate this effect are still unknown. The current study was perfomed to look into the control of β-catenin activity by endothelial cell-derived factors and to identify a mechanism by which they affect β-catenin activity in adrenocortical NCIH295R cells...
November 23, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27879404/targeting-cited2-for-angiogenesis-in-obesity-and-insulin-resistance
#3
Guanghong Jia, James R Sowers
No abstract text is available yet for this article.
December 2016: Diabetes
https://www.readbyqxmd.com/read/27874008/the-gcn5-cited2-pka-signalling-module-controls-hepatic-glucose-metabolism-through-a-camp-induced-substrate-switch
#4
Mashito Sakai, Tomoko Tujimura-Hayakawa, Takashi Yagi, Hiroyuki Yano, Masaru Mitsushima, Hiroyuki Unoki-Kubota, Yasushi Kaburagi, Hiroshi Inoue, Yoshiaki Kido, Masato Kasuga, Michihiro Matsumoto
Hepatic gluconeogenesis during fasting results from gluconeogenic gene activation via the glucagon-cAMP-protein kinase A (PKA) pathway, a process whose dysregulation underlies fasting hyperglycemia in diabetes. Such transcriptional activation requires epigenetic changes at promoters by mechanisms that have remained unclear. Here we show that GCN5 functions both as a histone acetyltransferase (HAT) to activate fasting gluconeogenesis and as an acetyltransferase for the transcriptional co-activator PGC-1α to inhibit gluconeogenesis in the fed state...
November 22, 2016: Nature Communications
https://www.readbyqxmd.com/read/27818139/cited2-cooperates-with-isl1-and-promotes-cardiac-differentiation-of-mouse-embryonic-stem-cells
#5
Ivette Pacheco-Leyva, Ana Catarina Matias, Daniel V Oliveira, João M A Santos, Rita Nascimento, Eduarda Guerreiro, Anna C Michell, Annebel M van De Vrugt, Gisela Machado-Oliveira, Guilherme Ferreira, Ibrahim Domian, José Bragança
The transcriptional regulator CITED2 is essential for heart development. Here, we investigated the role of CITED2 in the specification of cardiac cell fate from mouse embryonic stem cells (ESC). The overexpression of CITED2 in undifferentiated ESC was sufficient to promote cardiac cell emergence upon differentiation. Conversely, the depletion of Cited2 at the onset of differentiation resulted in a decline of ESC ability to generate cardiac cells. Moreover, loss of Cited2 expression impairs the expression of early mesoderm markers and cardiogenic transcription factors (Isl1, Gata4, Tbx5)...
October 31, 2016: Stem Cell Reports
https://www.readbyqxmd.com/read/27750106/breast-cancer-osteomimicry-and-its-role-in-bone-specific-metastasis-an%C3%A2-integrative-systematic-review-of-preclinical-evidence
#6
REVIEW
Olugbenga Awolaran, Susan A Brooks, Verna Lavender
Metastasis accounts for most of the deaths from breast cancer and the preference of invasive breast cancer metastasising to bone has been widely reported. However, the biological basis of breast cancer osteotropism is not fully understood. This paper provides, for the first time, an integrative, systematic review of evidence of molecular factors that have functional roles in the homing of metastatic breast cancer to the bone. Pubmed, Web of Science and EBSCOhost were searched using keywords and synonyms for molecular, metastasis, breast cancer and bone to identify articles published between January 2004 and August 2016...
December 2016: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/27680315/cited2-participates-in-cardiomyocyte-apoptosis-and-maternal-diabetes-induced-congenital-heart-abnormality
#7
Dongmei Su, Jun-Xian Song, Qianqian Gao, Lina Guan, Qian Li, Cuige Shi, Xu Ma
Gestational diabetes mellitus is a risk factor for abnormal heart development, but the molecular basis remains obscure. To further analyze this, the hyperglycemia rat and cell model were established in this study. The results showed that hyperglycemic rats gained significantly less weight during gestation than controls. The number of embryos per litter was significantly reduced in diabetic mothers compared to controls. Ventricular wall thickness was often decreased in the diabetic offspring and cardiomyocyte apoptosis participated in ventricular wall thinness...
October 28, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27629361/microrna-expression-profiling-and-functional-annotation-analysis-of-their-targets-modulated-by-oxidative-stress-during-embryonic-heart-development-in-diabetic-mice
#8
Daoyin Dong, Yuji Zhang, E Albert Reece, Lei Wang, Christopher R Harman, Peixin Yang
Maternal pregestational diabetes mellitus (PGDM) induces congenital heart defects (CHDs). The molecular mechanism underlying PGDM-induced CHDs is unknown. microRNAs (miRNAs), small non-coding RNAs, repress gene expression at the posttranscriptional level and play important roles in heart development. We performed a global miRNA profiling study to assist in revealing potential miRNAs modulated by PGDM and possible developmental pathways regulated by miRNAs during heart development. A total of 149 mapped miRNAs in the developing heart were significantly altered by PGDM...
October 2016: Reproductive Toxicology
https://www.readbyqxmd.com/read/27627783/cited2-in-breast-carcinoma-as-a-potent-prognostic-predictor-associated-with-proliferation-migration-and-chemoresistance
#9
Hiroyuki Minemura, Kiyoshi Takagi, Ai Sato, Hikaru Takahashi, Yasuhiro Miki, Yukiko Shibahara, Mika Watanabe, Takanori Ishida, Hironobu Sasano, Takashi Suzuki
CITED2 (Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2) is a member of the CITED family and is involved in various cellular functions during development and differentiation. Mounting evidence suggests the importance of CITED in the progression of human malignancies, but the significance of CITED2 protein has not yet been examined in breast carcinoma. Therefore, in the present study, we examined the clinical significance and the biological functions of CITED2 in breast carcinoma by immunohistochemistry and in vitro study...
September 14, 2016: Cancer Science
https://www.readbyqxmd.com/read/27561725/insulin-downregulates-the-transcriptional-coregulator-cited2-an-inhibitor-of-proangiogenic-function-in-endothelial-cells
#10
Xuanchun Wang, Samuel M Lockhart, Thomas Rathjen, Hassan Albadawi, Ditte Sørensen, Brian T O'Neill, Nishant Dwivedi, Simone R Preil, Hans Christian Beck, Sally L Dunwoodie, Michael T Watkins, Lars Melholt Rasmussen, Christian Rask-Madsen
In patients with atherosclerotic complications of diabetes, impaired neovascularization of ischemic tissue in the myocardium and lower limb limits the ability of these tissues to compensate for poor perfusion. We identified 10 novel insulin-regulated genes, among them Adm, Cited2, and Ctgf, which were downregulated in endothelial cells by insulin through FoxO1. CBP/p300-interacting transactivator with ED-rich tail 2 (CITED2), which was downregulated by insulin by up to 54%, is an important negative regulator of hypoxia-inducible factor (HIF) and impaired HIF signaling is a key mechanism underlying the impairment of angiogenesis in diabetes...
December 2016: Diabetes
https://www.readbyqxmd.com/read/27343102/modulation-of-the-hypoxic-response
#11
Christopher W Pugh
Hypoxia stimulates a variety of adaptive responses, many mediated via the hypoxia inducible factors (HIF) family of transcriptional complexes. The balance of HIF-1, -2 and -3 controls a variety of genes, directly up-regulating transcription of genes involved in erythropoiesis, angiogenesis, vasomotor tone, metabolic pathways and processes related to cell multiplication and survival, and indirectly reducing the transcription of genes with other effects. HIF transcription factors are heterodimers consisting of an oxygen-regulated alpha chain bound to the constitutive aryl hydrocarbon receptor nuclear translocator...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27307230/cited2-regulates-neocortical-layer-ii-iii-generation-and-somatosensory-callosal-projection-neuron-development-and-connectivity
#12
Ryann M Fame, Jessica L MacDonald, Sally L Dunwoodie, Emi Takahashi, Jeffrey D Macklis
UNLABELLED: The neocortex contains hundreds to thousands of distinct subtypes of precisely connected neurons, allowing it to perform remarkably complex tasks of high-level cognition. Callosal projection neurons (CPN) connect the cerebral hemispheres via the corpus callosum, integrating cortical information and playing key roles in associative cognition. CPN are a strikingly diverse set of neuronal subpopulations, and development of this diversity requires precise control by a complex, interactive set of molecular effectors...
June 15, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27260322/curcumin-slows-osteoarthritis-progression-and-relieves-osteoarthritis-associated-pain-symptoms-in-a-post-traumatic-osteoarthritis-mouse-model
#13
Zhuo Zhang, Daniel J Leong, Lin Xu, Zhiyong He, Angela Wang, Mahantesh Navati, Sun J Kim, David M Hirsh, John A Hardin, Neil J Cobelli, Joel M Friedman, Hui B Sun
BACKGROUND: Curcumin has been shown to have chondroprotective potential in vitro. However, its effect on disease and symptom modification in osteoarthritis (OA) is largely unknown. This study aimed to determine whether curcumin could slow progression of OA and relieve OA-related pain in a mouse model of destabilization of the medial meniscus (DMM). METHODS: Expression of selected cartilage degradative-associated genes was evaluated in human primary chondrocytes treated with curcumin and curcumin nanoparticles and assayed by real-time PCR...
2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27216153/cited2-modulates-breast-cancer-metastatic-ability-through-effects-on-ikk%C3%AE
#14
Swaathi Jayaraman, Michele Doucet, Wen Min Lau, Scott L Kominsky
UNLABELLED: Previously, we identified the transcriptional coactivator CITED2 as a potential facilitator of bone metastasis using a murine mammary cancer model. Extending these studies to human breast cancer, it was observed that CITED2 mRNA expression was significantly elevated in patient specimens of metastatic breast cancer relative to primary tumors, with highest levels in metastasis to bone relative to non-bone sites. To further evaluate CITED2 functions in breast cancer metastasis, CITED2 expression was stably reduced in the human breast cancer cell lines MDA-MB-231 and MDA-MB-468, which are metastatic in animal models...
August 2016: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/26917451/cited2-modulation-of-trophoblast-cell-differentiation-insights-from-global-transcriptome-analysis
#15
Kazuhiko Imakawa, Pramod Dhakal, Kaiyu Kubota, Kazuya Kusama, Damayanti Chakraborty, M A Karim Rumi, Michael J Soares
Trophoblast stem (TS) cells possess the capacity to differentiate along a multi-lineage pathway yielding several specialized cell types. The regulatory network controlling trophoblast cell differentiation is poorly understood. Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain, 2 (CITED2) has been implicated in the regulation of placentation; however, we know little about how CITED2 acts to influence trophoblast cells. Rat Rcho-1 TS cells can be manipulated to proliferate or differentiate into specialized trophoblast lineages and are an excellent model for investigating trophoblast differentiation...
May 2016: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/26874185/subtype-specific-genes-that-characterize-subpopulations-of-callosal-projection-neurons-in-mouse-identify-molecularly-homologous-populations-in-macaque-cortex
#16
Ryann M Fame, Colette Dehay, Henry Kennedy, Jeffrey D Macklis
Callosal projection neurons (CPN) interconnect the neocortical hemispheres via the corpus callosum and are implicated in associative integration of multimodal information. CPN have undergone differential evolutionary elaboration, leading to increased diversity of cortical neurons-and more extensive and varied connections in neocortical gray and white matter-in primates compared with rodents. In mouse, distinct sets of genes are enriched in discrete subpopulations of CPN, indicating the molecular diversity of rodent CPN...
February 13, 2016: Cerebral Cortex
https://www.readbyqxmd.com/read/26812245/cited2-protein-level-in-cumulus-cells-is-a-biomarker-for-human-embryo-quality-and-pregnancy-outcome-in%C3%A2-one-in%C3%A2-vitro-fertilization-cycle
#17
Yuan Fang, Wei Shang, De-Li Wei, Shen-Ming Zeng
OBJECTIVE: To determine whether the levels of CBP/p300 interacting transactivator with ED-rich tail 2 (Cited2) protein in cumulus cells (CCs) derived from patients undergoing IVF related to infertility factors, embryo quality, and clinical outcomes in one IVF cycle. DESIGN: Retrospective analysis of human CCs. SETTING: Public hospital and university. PATIENT(S): A total of 103 (conventional) IVF patients and 32 intracytoplasmic sperm injection patients...
May 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/26786313/the-potential-role-of-amygdaloid-microrna-494-in-alcohol-induced-anxiolysis
#18
Tara L Teppen, Harish R Krishnan, Huaibo Zhang, Amul J Sakharkar, Subhash C Pandey
BACKGROUND: The antianxiety effects of ethanol appear to be a crucial factor in promoting alcohol intake. Regulation of gene expression by microRNA (miRNA) is an important epigenetic mechanism that affects neuronal pathways and behaviors. We investigated the role of miRNAs underlying the mechanisms of ethanol-induced anxiolysis. METHODS: Acute ethanol-induced anxiolysis was measured in adult rats, and amygdaloid tissues were used for miRNA profiling by microarray analysis...
November 1, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/26774142/discovery-of-signature-genes-in-gastric-cancer-associated-with-prognosis
#19
X Zhao, H Cai, X Wang, L Ma
Gene expression profiles of gastric cancer (GC) were analyzed with bioinformatics tools to identify signature genes associated with prognosis. Four gene expression data sets (accession number: GSE2685, GSE30727, GSE38932 and GSE26253) were downloaded from Gene Expression Omnibus. Differentially expressed genes (DEGs) were screened out using significance analysis of microarrays (SAM) algorithm. P-value 1 were set as the threshold. A co-expression network was constructed for the GC-related genes with package WGCNA of R...
2016: Neoplasma
https://www.readbyqxmd.com/read/26687824/strain-induced-mechanotransduction-through-primary-cilia-extracellular-atp-purinergic-calcium-signaling-and-erk1-2-transactivates-cited2-and-downregulates-mmp-1-and-mmp-13-gene-expression-in-chondrocytes
#20
Z He, D J Leong, Z Zhuo, R J Majeska, L Cardoso, D C Spray, M B Goldring, N J Cobelli, H B Sun
OBJECTIVE: To determine the strain-induced signaling pathways involved in regulating the transactivation of the transcription regulator Cbp/p300 Interacting Transactivator with ED-rich tail 2 (CITED2) and downstream targets in chondrocytes. METHODS: Primary human chondrocytes or C28/I2 chondrocytic cells were subjected to various strain regimes. C57BL/6 mice were subjected to treadmill running. Loss-of-function was carried out using siRNA or inhibitors specific for targeted molecules...
May 2016: Osteoarthritis and Cartilage
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